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Conserved domains on  [gi|578821251|ref|XP_006718550|]
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EH domain-binding protein 1-like protein 1 isoform X4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NT-C2 pfam10358
N-terminal C2 in EEIG1 and EHBP1 proteins; This version of the C2 domain was initally ...
 12-164 2.57e-28

N-terminal C2 in EEIG1 and EHBP1 proteins; This version of the C2 domain was initally identified in the vertebrate estrogen early-induced gene 1 (EEIG1), and its Drosophila ortholog required for uptake of dsRNA via the endocytotic machinery to induce RNAi silencing. It is also in C.elegans ortholog Sym-3 (SYnthetic lethal with Mec-3) and the mammalian protein EHBP1 (EH domain Binding Protein-1) that regulates endocytotic recycling and two plant proteins, RPG that regulates Rhizobium-directed polar growth and PMI1 (Plastid Movement Impaired 1) that is essential for intracellular movement of chloroplasts in response to blue light.


:

Pssm-ID: 463058  Cd Length: 143  Bit Score: 111.26  E-value: 2.57e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251    12 GKRAAKFQFVACYHELVLECTkkwQPDKLVVVWTRRNrricSKAHSWQPGIQNPYRGTVVWmvPENVDISVTLYRDPHVD 91
Cdd:pfam10358    1 KKRKPKFQFVLTIHELQNLPL---VGGELFVKWRRGD----KKGSSGTTEKALVNNGRAIF--NEEFSIPVTLFLDKKGG 71

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578821251    92 QYEAKEWTFIIENESKGQRK-VLATAEVDLARHAGPVPVQVPVRLRLKPKSVKvvQAELSLTLSGVLLREGRAT 164
Cdd:pfam10358   72 KYEEKLLEFSVYKVTKKGKKkVLGKASIDLAEYANLKKKPTTVRFLLKKSSKK--NATLSLSIQVLPLGEDPND 143
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 185-567 3.32e-08

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 57.87  E-value: 3.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  185 LDDFAESDEDEAHGPGAPEARARVPQPGRggalrPGRFPDPSRELKTLCEEEEEGQGRPQQAVASPSNAEDTSPapvsap 264
Cdd:PHA03307   11 IEAAAEGGEFFPRPPATPGDAADDLLSGS-----QGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEA------ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  265 appartsrgQGSERANEAGGQVGPEAPRPPetsPEMRSSRQPAQDTA-------------PTPAPRLRKGSDALRPPVPQ 331
Cdd:PHA03307   80 ---------PANESRSTPTWSLSTLAPASP---AREGSPTPPGPSSPdpppptpppasppPSPAPDLSEMLRPVGSPGPP 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  332 GEDEVPKASGAPPAGLGSARETQAQACPQEGTEAHGARLG-PSIEDKGSGDPFGRQRLKAEemdtEDRPEASGVDTEPRS 410
Cdd:PHA03307  148 PAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSsPPAEPPPSTPPAAASPRPPR----RSSPISASASSPAPA 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  411 GGREANTKRSGVRAGEAEESSAVCQVDAEQRSKVRH---VDTKGPEATGVMPEARCRGTPEAPPRGSQGRLGVRTRDEAP 487
Cdd:PHA03307  224 PGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRpapITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSP 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  488 SGLSLPPAEPAGHSGQLGDLEG--ARAAAGQEREGAEVRGGAPGIEGTGLEQGPSVGAISTRPQVSSWQGALLSTAQGAI 565
Cdd:PHA03307  304 GSGPAPSSPRASSSSSSSRESSssSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAG 383


                  ..
gi 578821251  566 SR 567
Cdd:PHA03307  384 RP 385
PksD super family cl43841
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ...
 382-906 7.55e-05

Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];


The actual alignment was detected with superfamily member COG3321:

Pssm-ID: 442550 [Multi-domain]  Cd Length: 1386  Bit Score: 47.17  E-value: 7.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  382 PFGRQRLKAEEMDTEDRPEASGVDTEPRSGGREANTKRSGVRAGEAEESSAVCQVDAEQRSKVRHVDTKGPEATGVMPEA 461
Cdd:COG3321   867 PFQREDAAAALLAAALAAALAAAAALGALLLAALAAALAAALLALAAAAAAALALAAAALAALLALVALAAAAAALLALA 946

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  462 RCRGTPEAPPRGSQGRLGVRTRDEAPSGLSLPPAEPAGHSGQLGDLEGARAAAGQEREGAEVRGGAPGIEGTGLEQGPSV 541
Cdd:COG3321   947 AAAAAAAAALAAAEAGALLLLAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAALALLAAAALLLAAAAAAAALLALAA 1026

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  542 GAISTRPQVSSWQGALLSTAQGAISRGLGGWEAEAGGSGDLETETEVVGLEVLGTQEKEVEGSGFPETRTLEIEILGALE 621
Cdd:COG3321  1027 LLAAAAAALAAAAAAAAAAAALAALAAAAAAAAALALALAALLLLAALAELALAAAALALAAALAAAALALALAALAAAL 1106

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  622 KEAARSRVLESEVAGTAQcegleTQETEVGVIETPGTETEVLGTQKTEAGGSGVLQTRTTIAETEVLVTQEISGDLGPLK 701
Cdd:COG3321  1107 LLLALLAALALAAAAAAL-----LALAALLAAAAAAAALAAAAAAAAALALAAAAAALAAALAAALLAAAALLLALALAL 1181

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  702 IEDTIQSEMLGTQETEVEASRVPESEAEGTEAKILGTQEITARDSGVREIEAEIAESDILVAQEIEVGLLGVLGIETGAA 781
Cdd:COG3321  1182 AAALAAALAGLAALLLAALLAALLAALLALALAALAAAAAALLAAAAAAAALALLALAAAAAAVAALAAAAAALLAALAA 1261

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  782 EGAILGTQEIASRDSGVPGLEADTTGIQVKEVGGSEVPEIATGTAETEILGTQEIASRSSGVPGLESEVAGAQETEVGGS 861
Cdd:COG3321  1262 LALLAAAAGLAALAAAAAAAAAALALAAAAAAAAAALAALLAAAAAAAAAAAAAAAAAALAAALLAAALAALAAAVAAAL 1341

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
gi 578821251  862 GISGPEAGMAEARVLMTRKTEIIVPEAEKEEAQTSGVQEAETRVG 906
Cdd:COG3321  1342 ALAAAAAAAAAAAAAAAAAAALAAAAGAAAAAAALALAALAAAVA 1386
 
Name Accession Description Interval E-value
NT-C2 pfam10358
N-terminal C2 in EEIG1 and EHBP1 proteins; This version of the C2 domain was initally ...
 12-164 2.57e-28

N-terminal C2 in EEIG1 and EHBP1 proteins; This version of the C2 domain was initally identified in the vertebrate estrogen early-induced gene 1 (EEIG1), and its Drosophila ortholog required for uptake of dsRNA via the endocytotic machinery to induce RNAi silencing. It is also in C.elegans ortholog Sym-3 (SYnthetic lethal with Mec-3) and the mammalian protein EHBP1 (EH domain Binding Protein-1) that regulates endocytotic recycling and two plant proteins, RPG that regulates Rhizobium-directed polar growth and PMI1 (Plastid Movement Impaired 1) that is essential for intracellular movement of chloroplasts in response to blue light.


Pssm-ID: 463058  Cd Length: 143  Bit Score: 111.26  E-value: 2.57e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251    12 GKRAAKFQFVACYHELVLECTkkwQPDKLVVVWTRRNrricSKAHSWQPGIQNPYRGTVVWmvPENVDISVTLYRDPHVD 91
Cdd:pfam10358    1 KKRKPKFQFVLTIHELQNLPL---VGGELFVKWRRGD----KKGSSGTTEKALVNNGRAIF--NEEFSIPVTLFLDKKGG 71

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578821251    92 QYEAKEWTFIIENESKGQRK-VLATAEVDLARHAGPVPVQVPVRLRLKPKSVKvvQAELSLTLSGVLLREGRAT 164
Cdd:pfam10358   72 KYEEKLLEFSVYKVTKKGKKkVLGKASIDLAEYANLKKKPTTVRFLLKKSSKK--NATLSLSIQVLPLGEDPND 143
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 185-567 3.32e-08

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 57.87  E-value: 3.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  185 LDDFAESDEDEAHGPGAPEARARVPQPGRggalrPGRFPDPSRELKTLCEEEEEGQGRPQQAVASPSNAEDTSPapvsap 264
Cdd:PHA03307   11 IEAAAEGGEFFPRPPATPGDAADDLLSGS-----QGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEA------ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  265 appartsrgQGSERANEAGGQVGPEAPRPPetsPEMRSSRQPAQDTA-------------PTPAPRLRKGSDALRPPVPQ 331
Cdd:PHA03307   80 ---------PANESRSTPTWSLSTLAPASP---AREGSPTPPGPSSPdpppptpppasppPSPAPDLSEMLRPVGSPGPP 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  332 GEDEVPKASGAPPAGLGSARETQAQACPQEGTEAHGARLG-PSIEDKGSGDPFGRQRLKAEemdtEDRPEASGVDTEPRS 410
Cdd:PHA03307  148 PAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSsPPAEPPPSTPPAAASPRPPR----RSSPISASASSPAPA 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  411 GGREANTKRSGVRAGEAEESSAVCQVDAEQRSKVRH---VDTKGPEATGVMPEARCRGTPEAPPRGSQGRLGVRTRDEAP 487
Cdd:PHA03307  224 PGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRpapITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSP 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  488 SGLSLPPAEPAGHSGQLGDLEG--ARAAAGQEREGAEVRGGAPGIEGTGLEQGPSVGAISTRPQVSSWQGALLSTAQGAI 565
Cdd:PHA03307  304 GSGPAPSSPRASSSSSSSRESSssSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAG 383


                  ..
gi 578821251  566 SR 567
Cdd:PHA03307  384 RP 385
PksD COG3321
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ...
 382-906 7.55e-05

Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442550 [Multi-domain]  Cd Length: 1386  Bit Score: 47.17  E-value: 7.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  382 PFGRQRLKAEEMDTEDRPEASGVDTEPRSGGREANTKRSGVRAGEAEESSAVCQVDAEQRSKVRHVDTKGPEATGVMPEA 461
Cdd:COG3321   867 PFQREDAAAALLAAALAAALAAAAALGALLLAALAAALAAALLALAAAAAAALALAAAALAALLALVALAAAAAALLALA 946

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  462 RCRGTPEAPPRGSQGRLGVRTRDEAPSGLSLPPAEPAGHSGQLGDLEGARAAAGQEREGAEVRGGAPGIEGTGLEQGPSV 541
Cdd:COG3321   947 AAAAAAAAALAAAEAGALLLLAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAALALLAAAALLLAAAAAAAALLALAA 1026

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  542 GAISTRPQVSSWQGALLSTAQGAISRGLGGWEAEAGGSGDLETETEVVGLEVLGTQEKEVEGSGFPETRTLEIEILGALE 621
Cdd:COG3321  1027 LLAAAAAALAAAAAAAAAAAALAALAAAAAAAAALALALAALLLLAALAELALAAAALALAAALAAAALALALAALAAAL 1106

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  622 KEAARSRVLESEVAGTAQcegleTQETEVGVIETPGTETEVLGTQKTEAGGSGVLQTRTTIAETEVLVTQEISGDLGPLK 701
Cdd:COG3321  1107 LLLALLAALALAAAAAAL-----LALAALLAAAAAAAALAAAAAAAAALALAAAAAALAAALAAALLAAAALLLALALAL 1181

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  702 IEDTIQSEMLGTQETEVEASRVPESEAEGTEAKILGTQEITARDSGVREIEAEIAESDILVAQEIEVGLLGVLGIETGAA 781
Cdd:COG3321  1182 AAALAAALAGLAALLLAALLAALLAALLALALAALAAAAAALLAAAAAAAALALLALAAAAAAVAALAAAAAALLAALAA 1261

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  782 EGAILGTQEIASRDSGVPGLEADTTGIQVKEVGGSEVPEIATGTAETEILGTQEIASRSSGVPGLESEVAGAQETEVGGS 861
Cdd:COG3321  1262 LALLAAAAGLAALAAAAAAAAAALALAAAAAAAAAALAALLAAAAAAAAAAAAAAAAAALAAALLAAALAALAAAVAAAL 1341

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
gi 578821251  862 GISGPEAGMAEARVLMTRKTEIIVPEAEKEEAQTSGVQEAETRVG 906
Cdd:COG3321  1342 ALAAAAAAAAAAAAAAAAAAALAAAAGAAAAAAALALAALAAAVA 1386
 
Name Accession Description Interval E-value
NT-C2 pfam10358
N-terminal C2 in EEIG1 and EHBP1 proteins; This version of the C2 domain was initally ...
 12-164 2.57e-28

N-terminal C2 in EEIG1 and EHBP1 proteins; This version of the C2 domain was initally identified in the vertebrate estrogen early-induced gene 1 (EEIG1), and its Drosophila ortholog required for uptake of dsRNA via the endocytotic machinery to induce RNAi silencing. It is also in C.elegans ortholog Sym-3 (SYnthetic lethal with Mec-3) and the mammalian protein EHBP1 (EH domain Binding Protein-1) that regulates endocytotic recycling and two plant proteins, RPG that regulates Rhizobium-directed polar growth and PMI1 (Plastid Movement Impaired 1) that is essential for intracellular movement of chloroplasts in response to blue light.


Pssm-ID: 463058  Cd Length: 143  Bit Score: 111.26  E-value: 2.57e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251    12 GKRAAKFQFVACYHELVLECTkkwQPDKLVVVWTRRNrricSKAHSWQPGIQNPYRGTVVWmvPENVDISVTLYRDPHVD 91
Cdd:pfam10358    1 KKRKPKFQFVLTIHELQNLPL---VGGELFVKWRRGD----KKGSSGTTEKALVNNGRAIF--NEEFSIPVTLFLDKKGG 71

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578821251    92 QYEAKEWTFIIENESKGQRK-VLATAEVDLARHAGPVPVQVPVRLRLKPKSVKvvQAELSLTLSGVLLREGRAT 164
Cdd:pfam10358   72 KYEEKLLEFSVYKVTKKGKKkVLGKASIDLAEYANLKKKPTTVRFLLKKSSKK--NATLSLSIQVLPLGEDPND 143
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 185-567 3.32e-08

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 57.87  E-value: 3.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  185 LDDFAESDEDEAHGPGAPEARARVPQPGRggalrPGRFPDPSRELKTLCEEEEEGQGRPQQAVASPSNAEDTSPapvsap 264
Cdd:PHA03307   11 IEAAAEGGEFFPRPPATPGDAADDLLSGS-----QGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEA------ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  265 appartsrgQGSERANEAGGQVGPEAPRPPetsPEMRSSRQPAQDTA-------------PTPAPRLRKGSDALRPPVPQ 331
Cdd:PHA03307   80 ---------PANESRSTPTWSLSTLAPASP---AREGSPTPPGPSSPdpppptpppasppPSPAPDLSEMLRPVGSPGPP 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  332 GEDEVPKASGAPPAGLGSARETQAQACPQEGTEAHGARLG-PSIEDKGSGDPFGRQRLKAEemdtEDRPEASGVDTEPRS 410
Cdd:PHA03307  148 PAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSsPPAEPPPSTPPAAASPRPPR----RSSPISASASSPAPA 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  411 GGREANTKRSGVRAGEAEESSAVCQVDAEQRSKVRH---VDTKGPEATGVMPEARCRGTPEAPPRGSQGRLGVRTRDEAP 487
Cdd:PHA03307  224 PGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRpapITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSP 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  488 SGLSLPPAEPAGHSGQLGDLEG--ARAAAGQEREGAEVRGGAPGIEGTGLEQGPSVGAISTRPQVSSWQGALLSTAQGAI 565
Cdd:PHA03307  304 GSGPAPSSPRASSSSSSSRESSssSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAG 383


                  ..
gi 578821251  566 SR 567
Cdd:PHA03307  384 RP 385
PksD COG3321
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ...
 382-906 7.55e-05

Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442550 [Multi-domain]  Cd Length: 1386  Bit Score: 47.17  E-value: 7.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  382 PFGRQRLKAEEMDTEDRPEASGVDTEPRSGGREANTKRSGVRAGEAEESSAVCQVDAEQRSKVRHVDTKGPEATGVMPEA 461
Cdd:COG3321   867 PFQREDAAAALLAAALAAALAAAAALGALLLAALAAALAAALLALAAAAAAALALAAAALAALLALVALAAAAAALLALA 946

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  462 RCRGTPEAPPRGSQGRLGVRTRDEAPSGLSLPPAEPAGHSGQLGDLEGARAAAGQEREGAEVRGGAPGIEGTGLEQGPSV 541
Cdd:COG3321   947 AAAAAAAAALAAAEAGALLLLAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAALALLAAAALLLAAAAAAAALLALAA 1026

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  542 GAISTRPQVSSWQGALLSTAQGAISRGLGGWEAEAGGSGDLETETEVVGLEVLGTQEKEVEGSGFPETRTLEIEILGALE 621
Cdd:COG3321  1027 LLAAAAAALAAAAAAAAAAAALAALAAAAAAAAALALALAALLLLAALAELALAAAALALAAALAAAALALALAALAAAL 1106

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  622 KEAARSRVLESEVAGTAQcegleTQETEVGVIETPGTETEVLGTQKTEAGGSGVLQTRTTIAETEVLVTQEISGDLGPLK 701
Cdd:COG3321  1107 LLLALLAALALAAAAAAL-----LALAALLAAAAAAAALAAAAAAAAALALAAAAAALAAALAAALLAAAALLLALALAL 1181

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  702 IEDTIQSEMLGTQETEVEASRVPESEAEGTEAKILGTQEITARDSGVREIEAEIAESDILVAQEIEVGLLGVLGIETGAA 781
Cdd:COG3321  1182 AAALAAALAGLAALLLAALLAALLAALLALALAALAAAAAALLAAAAAAAALALLALAAAAAAVAALAAAAAALLAALAA 1261

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  782 EGAILGTQEIASRDSGVPGLEADTTGIQVKEVGGSEVPEIATGTAETEILGTQEIASRSSGVPGLESEVAGAQETEVGGS 861
Cdd:COG3321  1262 LALLAAAAGLAALAAAAAAAAAALALAAAAAAAAAALAALLAAAAAAAAAAAAAAAAAALAAALLAAALAALAAAVAAAL 1341

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
gi 578821251  862 GISGPEAGMAEARVLMTRKTEIIVPEAEKEEAQTSGVQEAETRVG 906
Cdd:COG3321  1342 ALAAAAAAAAAAAAAAAAAAALAAAAGAAAAAAALALAALAAAVA 1386
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 191-556 2.07e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 45.36  E-value: 2.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  191 SDEDEAHGPGAPEARARVPQPGRGGALRPGRFPDPSRELKTlceEEEEGQGRPQQAVASPSNAEDTSPAPVSAPAPPART 270
Cdd:PRK07764  388 AGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAA---PQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSA 464

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  271 SRGQGSERANEAGGQVGPEAPRPPETSPEMRSSRQPAQDTAPTPAPRLRKGSDALRppvpqgeDEVPKASGAPPAglgsA 350
Cdd:PRK07764  465 QPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATLRERWPEIL-------AAVPKRSRKTWA----I 533

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  351 RETQAQACPQEG--------TEAHGARLGPS-------------------IEDKGSGDPFGRQRLKAEEMDTEDRPEASG 403
Cdd:PRK07764  534 LLPEATVLGVRGdtlvlgfsTGGLARRFASPgnaevlvtalaeelggdwqVEAVVGPAPGAAGGEGPPAPASSGPPEEAA 613

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  404 VDTEPRSGGREANTKRSGVRAGEAEESSAVCQVDAEQRSKVRHV------DTKGPEATGVMPEARCRGTPEAPPRGSQGR 477
Cdd:PRK07764  614 RPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVavpdasDGGDGWPAKAGGAAPAAPPPAPAPAAPAAP 693

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  478 LGVRTRDEAPSGLSLPPAEPAGHSGQLGDLEGARAAAGQEREGAEVR-GGAPGIEGTGLEQGPSVGAISTRPQVSSWQGA 556
Cdd:PRK07764  694 AGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPlPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAA 773
PHA03247 PHA03247
large tegument protein UL36; Provisional
 195-552 2.72e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 2.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  195 EAHGPGAPEArarVPQPGRGGALRPGRFPDPSRELKTLCEEEEEGQ---------------------------------- 240
Cdd:PHA03247 2485 EARFPFAAGA---APDPGGGGPPDPDAPPAPSRLAPAILPDEPVGEpvhprmltwirgleelasddagdpppplppaapp 2561

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  241 GRPQQAVASPSNA----EDTSPAPVSAPAPPARTSRGQ------GSERANEAGGQVGPE--APRPPETSPEMRSSRQPAQ 308
Cdd:PHA03247 2562 AAPDRSVPPPRPAprpsEPAVTSRARRPDAPPQSARPRapvddrGDPRGPAPPSPLPPDthAPDPPPPSPSPAANEPDPH 2641

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  309 DTAPTPAP-------------RLRKGSDALRPPVPQGEDEVPKASGAPPAgLGSARETqAQACPQEGTEAHGARLGPSIE 375
Cdd:PHA03247 2642 PPPTVPPPerprddpapgrvsRPRRARRLGRAAQASSPPQRPRRRAARPT-VGSLTSL-ADPPPPPPTPEPAPHALVSAT 2719

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  376 DKGSGDPFGRQRLKAEEMDTEDRPEASGvdtePRSGGREANTKRSGVRAGEAEESSAVCQVDAEQRSKVRHVDTKGPEAT 455
Cdd:PHA03247 2720 PLPPGPAAARQASPALPAAPAPPAVPAG----PATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESR 2795

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  456 GVMPEARcrgTPEAPPRGSQGRLGVRTRDEAPSGLSLPP--AEPAGHSGQLGDLEGARAAAGQEREGAEVRGGAPGiegt 533
Cdd:PHA03247 2796 ESLPSPW---DPADPPAAVLAPAAALPPAASPAGPLPPPtsAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPS---- 2868

                         410
                  ....*....|....*....
gi 578821251  534 glEQGPSVGAISTRPQVSS 552
Cdd:PHA03247 2869 --RSPAAKPAAPARPPVRR 2885
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 189-509 5.98e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.01  E-value: 5.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  189 AESDEDEAHGPGAPEARARVPQ-------PGRGGALRPGRFPDPSRELKTLCEEEEEGQG------RPQQAVASPSNAED 255
Cdd:PHA03307  103 EGSPTPPGPSSPDPPPPTPPPAspppspaPDLSEMLRPVGSPGPPPAASPPAAGASPAAVasdaasSRQAALPLSSPEET 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  256 TSPAPVSAPAPPARTSRGQGSERANEAGGQVGPEAPRPPETSPEM--RSSRQPAQDTAPTPAPRLRKGSDALRPPVPQGE 333
Cdd:PHA03307  183 ARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSaaDDAGASSSDSSSSESSGCGWGPENECPLPRPAP 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  334 DEVPKASGAPPAGLGSARETQAQAcPQEGTEAHGARLGPSIEDKGSGDPfGRQRLKAEEMDTEDRPEASGvDTEPRSGGR 413
Cdd:PHA03307  263 ITLPTRIWEASGWNGPSSRPGPAS-SSSSPRERSPSPSPSSPGSGPAPS-SPRASSSSSSSRESSSSSTS-SSSESSRGA 339

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  414 EANTKRSGVRAGEAEESSAVCQVDAEQRSKVRHVDTKGPEATGVMPEARCRGTPEAPPRGSQGRLGVRTRD-EAPSGLSL 492
Cdd:PHA03307  340 AVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGrPRPSPLDA 419

                         330
                  ....*....|....*...
gi 578821251  493 PPAEPAGH-SGQLGDLEG 509
Cdd:PHA03307  420 GAASGAFYaRYPLLTPSG 437
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 199-405 1.16e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.05  E-value: 1.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  199 PGAPEARARVPQPGRGGALRPGRFPDPSRELKTLCEEEEEGQgrpqQAVASPSNAEDTSPAPVSAPAPPARTSRGQGSER 278
Cdd:PRK07764  615 PAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKH----VAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAP 690

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  279 ANEAGGQVGPEAPRPPETSPEMRSSRQPAQDTAPTPAPRLRKGSDALRPPVPQGEDEVPKASGAPPAGLGSARETQAQAC 358
Cdd:PRK07764  691 AAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAP 770

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 578821251  359 PQEGTEAHGARLGPSIEDkgsgdpfgrqrlKAEEMDTEDR--PEASGVD 405
Cdd:PRK07764  771 AAAPPPSPPSEEEEMAED------------DAPSMDDEDRrdAEEVAME 807
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 178-470 1.42e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 42.75  E-value: 1.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  178 KPSDVGNLDDFAESDEDEAHG-PGAPEARARVPQPGRGGALRPGRFPDPSRElktlceeeEEGQGRPQqavaSPSNAEDT 256
Cdd:PTZ00449  527 KEGEEGEHEDSKESDEPKEGGkPGETKEGEVGKKPGPAKEHKPSKIPTLSKK--------PEFPKDPK----HPKDPEEP 594

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  257 spapvsapappartsrgQGSERANEAGGQVGPEAPRPPETSPEMRSSRQPAQDTAPTPAPRLRKGSDALRPPVPQgedeV 336
Cdd:PTZ00449  595 -----------------KKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQRPSSPERPEGPK----I 653

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  337 PKASGAPPA-------------------GLGSARETQAQACPQEGTEAHGARLGPsiedKGSGDPFGRQRL------KAE 391
Cdd:PTZ00449  654 IKSPKPPKSpkppfdpkfkekfyddyldAAAKSKETKTTVVLDESFESILKETLP----ETPGTPFTTPRPlppklpRDE 729

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  392 EMDTEDRPEASGVDTEPRSGGREANTKRsgVRAGEAEESSAVCQVDAEQ-RSKVRHVDTKGPEATGVMPEARCRGTPEAP 470
Cdd:PTZ00449  730 EFPFEPIGDPDAEQPDDIEFFTPPEEER--TFFHETPADTPLPDILAEEfKEEDIHAETGEPDEAMKRPDSPSEHEDKPP 807
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 189-357 2.47e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.90  E-value: 2.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  189 AESDEDEAHGPGAPEARARVPQPGRGGALRPGRFPDPSR----ELKTLCEEEEEGQGRPQQAVASPSNAEDTSPAPVSAP 264
Cdd:PRK07764  626 APAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDggdgWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAP 705

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  265 APPARTSRGQGSERANEAGGQ-------VGPEAPRPPETSPEMRSSRQPAQDTAPTPAPRLRKGSDALRPPVPQGEDEVP 337
Cdd:PRK07764  706 AATPPAGQADDPAAQPPQAAQgasapspAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEM 785

                         170       180
                  ....*....|....*....|
gi 578821251  338 KASGAPPAGLGSARETQAQA 357
Cdd:PRK07764  786 AEDDAPSMDDEDRRDAEEVA 805
dnaA PRK14086
chromosomal replication initiator protein DnaA;
192-372 4.61e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 40.96  E-value: 4.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  192 DEDEAHGPGAPEARARVPQPGRGGAL--------------RPGRFPDPSrelktlceeeeEGQGRPQQAVASPSNAEDTS 257
Cdd:PRK14086  114 GRRPYEGYGGPRADDRPPGLPRQDQLptarpaypayqqrpEPGAWPRAA-----------DDYGWQQQRLGFPPRAPYAS 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  258 PAPVSAPAPPARTSRGQGseRANEAGGQVGPEAPRPpetspemrSSRQPAQDTAPTPAPRLRKGSDALRPPVPQGEDEVP 337
Cdd:PRK14086  183 PASYAPEQERDREPYDAG--RPEYDQRRRDYDHPRP--------DWDRPRRDRTDRPEPPPGAGHVHRGGPGPPERDDAP 252

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 578821251  338 KASGAPPAGLGSARETQAQACPQEGTeahgARLGP 372
Cdd:PRK14086  253 VVPIRPSAPGPLAAQPAPAPGPGEPT----ARLNP 283
PHA03247 PHA03247
large tegument protein UL36; Provisional
 179-557 5.81e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 5.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  179 PSDVGNLDDFAESDEDEAHGPGAPEARARVPQPGRGGALRPGRFPDPSRELK----TLCEEEEEGQGRP--QQAVASPSN 252
Cdd:PHA03247 2618 PPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRlgraAQASSPPQRPRRRaaRPTVGSLTS 2697

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  253 AEDTSPAPVSAPAPPARTSRGQGSERANEAGGQVGPEAPRPPETSPemrSSRQPAQDTAPTPAPRLRKGSDALRPPVPQG 332
Cdd:PHA03247 2698 LADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPA---VPAGPATPGGPARPARPPTTAGPPAPAPPAA 2774

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  333 EDEVPKASGAPPAGLGSARETQAQACPQEGTEAHGARLGPSIEDKGSGDPFGRQRLKAEEMDTEDRPEASGVDTEPRSGG 412
Cdd:PHA03247 2775 PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGG 2854

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  413 REANtkrSGVRAGEAEESSAVCQVDAEQRSKVRHV------DTKGPEATGVMPEARCRGTPEAPPRGSQGRLGVRTRD-- 484
Cdd:PHA03247 2855 SVAP---GGDVRRRPPSRSPAAKPAAPARPPVRRLarpavsRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPqp 2931

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821251  485 -EAPSGLSLPPAEPAGHSGQLGDLEGaraAAGQEREGAEVRGGAPGIEGTGLEQGPSVGAISTR---------PQVSSWQ 554
Cdd:PHA03247 2932 pPPPPPRPQPPLAPTTDPAGAGEPSG---AVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASStppltghslSRVSSWA 3008


                  ...
gi 578821251  555 GAL 557
Cdd:PHA03247 3009 SSL 3011
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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