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transmembrane and coiled-coil domain-containing protein 3 isoform X3 [Homo sapiens]
Protein Classification
cation:proton antiporter ( domain architecture ID 11111152 )
cation:proton antiporter functions in maintaining cation homeostasis and the pH of actively metabolizing cells; it may also be involved in regulating cell volume; similar to K(+) efflux antiporters that are involved in K(+) homeostasis and osmotic adjustment
List of domain hits
Name
Accession
Description
Interval
E-value
RosB super family
cl47355 Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and ...
267-645
9.63e-64
Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and metabolism];
COG4651 :Pssm-ID: 443689 [Multi-domain]
Cd Length: 564
Bit Score: 221.39
E-value: 9.63e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 267 DHHF I KD I VT I GM L SLPC G W L CTAIGL P TMF GY IIC GVL L GP SGLNSIKSIVQV E T L G E F GV FFT LF L VGLEFS PEK L RK 346
Cdd:COG4651 3 ETPL I TT I AL I LG L AAVL G L L AQRLRQ P PIV GY LLA GVL I GP FTPGLVADVELI E Q L A E I GV ILL LF G VGLEFS LKD L LA 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 347 V W KI S L Q G PCYMTL L MIAF G LLWGH LL RIKPTQ S VFISTC LSLSST PLVSRF L mg SA RG dk E G D IDYSTVLL G M L VT QD V 426
Cdd:COG4651 83 V R KI A L P G ALLQIA L TTLL G FGIAL LL GWSLGE S LVFGLA LSLSST VVLLKL L -- ED RG -- E L D TLHGRIAV G W L IV QD L 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 427 QLG L FMAVM P T L IQA G AS asssivvevlr I L VLI G QI L FSL A AVFL L C LV IKKYL I GPYYRK lh MESKGNK E ILI L GIS A 506
Cdd:COG4651 159 AVV L MLVLL P A L AGG G GG ----------- L L GTL G LT L LKV A LFVA L M LV VGRRV I PWLLHR -- VARTRSR E LFL L AVL A 225
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 507 FIFLMLTVTE L LDV S ME LG C FLAG ALVSSQG pv VTEEI A TSIE P I RD FL A IV FF A S I G LHVF P T F VAYELTVLVF L T L S V 586
Cdd:COG4651 226 ICLGVAYLAA L FGL S FA LG A FLAG MVLAESE -- YSHQA A AELL P L RD AF A VL FF V S V G MLFD P S F LLENPLPVLA L L L I V 303
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 578825327 587 VVM K F L L A A L VLSLI lp RSSQYIKWI V SAG LAQ VS EFSF V L GSRARRA G VI S R E V Y L LI 645
Cdd:COG4651 304 LIG K P L I A F L IVLAL -- GYPLRTALL V GLS LAQ IG EFSF I L AALGLSL G LL S E E A Y Q LI 360
Name
Accession
Description
Interval
E-value
RosB
COG4651 Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and ...
267-645
9.63e-64
Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and metabolism];
Pssm-ID: 443689 [Multi-domain]
Cd Length: 564
Bit Score: 221.39
E-value: 9.63e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 267 DHHF I KD I VT I GM L SLPC G W L CTAIGL P TMF GY IIC GVL L GP SGLNSIKSIVQV E T L G E F GV FFT LF L VGLEFS PEK L RK 346
Cdd:COG4651 3 ETPL I TT I AL I LG L AAVL G L L AQRLRQ P PIV GY LLA GVL I GP FTPGLVADVELI E Q L A E I GV ILL LF G VGLEFS LKD L LA 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 347 V W KI S L Q G PCYMTL L MIAF G LLWGH LL RIKPTQ S VFISTC LSLSST PLVSRF L mg SA RG dk E G D IDYSTVLL G M L VT QD V 426
Cdd:COG4651 83 V R KI A L P G ALLQIA L TTLL G FGIAL LL GWSLGE S LVFGLA LSLSST VVLLKL L -- ED RG -- E L D TLHGRIAV G W L IV QD L 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 427 QLG L FMAVM P T L IQA G AS asssivvevlr I L VLI G QI L FSL A AVFL L C LV IKKYL I GPYYRK lh MESKGNK E ILI L GIS A 506
Cdd:COG4651 159 AVV L MLVLL P A L AGG G GG ----------- L L GTL G LT L LKV A LFVA L M LV VGRRV I PWLLHR -- VARTRSR E LFL L AVL A 225
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 507 FIFLMLTVTE L LDV S ME LG C FLAG ALVSSQG pv VTEEI A TSIE P I RD FL A IV FF A S I G LHVF P T F VAYELTVLVF L T L S V 586
Cdd:COG4651 226 ICLGVAYLAA L FGL S FA LG A FLAG MVLAESE -- YSHQA A AELL P L RD AF A VL FF V S V G MLFD P S F LLENPLPVLA L L L I V 303
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 578825327 587 VVM K F L L A A L VLSLI lp RSSQYIKWI V SAG LAQ VS EFSF V L GSRARRA G VI S R E V Y L LI 645
Cdd:COG4651 304 LIG K P L I A F L IVLAL -- GYPLRTALL V GLS LAQ IG EFSF I L AALGLSL G LL S E E A Y Q LI 360
Na_H_Exchanger
pfam00999 Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
274-645
4.85e-53
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.
Pssm-ID: 425982 [Multi-domain]
Cd Length: 377
Bit Score: 187.08
E-value: 4.85e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 274 IV TIGM L S L PCGW L CTAIG LP TMF G Y II C G V LLGPSGL NS I KSI - VQV E T L GEF G VFFT LFL V GLE FSPEK LRK VWKIS L 352
Cdd:pfam00999 1 IV LLIL L A L LAPL L ARRLK LP PIV G L II A G I LLGPSGL GL I SEV d EDL E V L SNL G LPPL LFL A GLE LDLRE LRK NGGSI L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 353 QGPCYMT L LMIAF -- G LL WGHL L R I KPTQSVFISTC LS LS S TPL V SRF L MGSA R GDK egdi DYS T V LLG ML V TQ D VQLGL 430
Cdd:pfam00999 81 LLALLGV L IPFVL ig L LL YLLG L G I PLLEALLFGAI LS AT S PVV V LAI L KELG R VPE ---- RLG T L LLG ES V LN D GVAVV 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 431 FM AV MPT L I Q AGASA S S sivvevlri L VLIGQ I LFSL A AVF LL CLVI kkyl IG PYY R KLHMESKGNK E ILI L GISAFIF L 510
Cdd:pfam00999 157 LL AV LLA L A Q GVGGG S D --------- L GWLLL I FLVV A VGG LL LGLL ---- IG WLL R LITRFTDDDR E LEV L LVLLLAL L 223
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 511 MLTVT E L L D VS ME LG C FLAG ALV S sq GPVVTEEIATSI EP IRDF L AI - V FF ASI GL HVFPTFVAYELTV LV F L T L SVVVM 589
Cdd:pfam00999 224 AALLA E A L G VS GI LG A FLAG LVL S -- EYPFANKLSEKL EP FGYG L FN p L FF VLV GL SLDLSSLLLSVWI LV L L A L VAILL 301
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 578825327 590 KFL L AALV L SLI L PR S SQY i KW I VSA G LA Q VSEF S FV L GSRARRA G V I S RE V Y L L I 645
Cdd:pfam00999 302 GRF L GVFL L LRL L GL S LRE - AL I IGF G GL Q RGAV S LA L AAIGPLL G I I A RE L Y P L L 356
2a37
TIGR00932 transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding ...
284-567
2.39e-32
transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273348 [Multi-domain]
Cd Length: 273
Bit Score: 126.22
E-value: 2.39e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 284 CGW L CTAI G L P TMF GY IIC GVL L GPSGL NS I KSIVQ V ET L G EFGV FFTL FL V GLE FSP E K L R K VW K ISL - Q G PCYMTLLM 362
Cdd:TIGR00932 7 AVP L SRRL G I P SVL GY LLA GVL I GPSGL GL I SNVEG V NH L A EFGV ILLM FL I GLE LDL E R L W K LR K AAF g V G VLQVLVPG 86
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 363 IAF GLL W GHLL RIKPTQS V F I STC L S LSST PL V SRF L mgsa RGDKEGDIDYSTVL LG M L VT QD VQLGLFM A VM P T L iqa G 442
Cdd:TIGR00932 87 VLL GLL L GHLL GLALGAA V V I GII L A LSST AV V VQV L ---- KERGLLKTPFGQTV LG I L LF QD IAVVPLL A LL P L L --- A 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 443 A SAS SS ivvevlri L V LIGQI L FSLAAV FLL CLVIKKY L IG P YY R KLH me SKGNK E ILIL G ISAFI F LMLTVTE LL DV SM 522
Cdd:TIGR00932 160 T SAS TE -------- H V ALALL L LKVFLA FLL LVLLGRW L LR P VL R LTA -- ELRPS E LFTA G SLLLM F GSAYFAD LL GL SM 229
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 578825327 523 E LG C FLAG ALV S SQ gp VVTEEIATSI EPI RDF L AIV FF A S I G LH V 567
Cdd:TIGR00932 230 A LG A FLAG VVL S ES -- EYRHKLESDL EPI GGV L LPL FF I S V G MS V 272
PRK03562
PRK03562 glutathione-regulated potassium-efflux system protein KefC; Provisional
290-640
1.31e-21
glutathione-regulated potassium-efflux system protein KefC; Provisional
Pssm-ID: 235131 [Multi-domain]
Cd Length: 621
Bit Score: 99.30
E-value: 1.31e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 290 AI GL PTMF GY I I C G VLL GP S GL NSIKSIVQVETLG EFGV FFT LF LV GLE FS P EK L rkv WK I -------- S LQ - GP C ym TL 360
Cdd:PRK03562 26 RL GL GSVL GY L I A G CII GP W GL RLVTDVESILHFA EFGV VLM LF VI GLE LD P QR L --- WK L rrsifggg A LQ m VA C -- GG 100
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 361 L MIA F GL L W G HLLRI kptq SVF I STC L S LSST P ----- LVS R F LM GSAR G DKE gdidystvl LGM L VT QD VQLGLFM A VM 435
Cdd:PRK03562 101 L LGL F CM L L G LRWQV ---- ALL I GLG L A LSST A iamqa MNE R N LM VTQM G RSA --------- FAI L LF QD IAAIPLV A MI 167
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 436 P T L IQA GAS - ASSSIVVEV L RILVLI gqilfsl A A V F L L clvi KK Y LIG P YY R kl HMESK G NK E I ------- L IL G ISA f 507
Cdd:PRK03562 168 P L L AAS GAS t TLGAFALSA L KVAGAL ------- A L V V L G ---- GR Y VTR P AL R -- FVARS G LR E V ftavalf L VF G FGL - 233
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 508 if LM ltvt E LLDV SM E LG C FLAG A L VS S qgpvv T E --- EIATS IEP IRDF L AIV FF ASI G LHV - F P T FVAYE L TV L VF L T 583
Cdd:PRK03562 234 -- LM ---- E EVGL SM A LG A FLAG V L LA S ----- S E yrh ALESD IEP FKGL L LGL FF IAV G MSI d F G T LLENP L RI L IL L L 302
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 578825327 584 LSVVVMKFL L AA L VLS L IL PR SSQ yik WIVSAG L A Q VS EF S FV LGSR A RR A G V ISR E 640
Cdd:PRK03562 303 GFLAIKIAM L WL L ARP L GV PR KQR --- RWFAVL L G Q GG EF A FV VFGA A QM A N V LEP E 356
Name
Accession
Description
Interval
E-value
RosB
COG4651 Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and ...
267-645
9.63e-64
Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and metabolism];
Pssm-ID: 443689 [Multi-domain]
Cd Length: 564
Bit Score: 221.39
E-value: 9.63e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 267 DHHF I KD I VT I GM L SLPC G W L CTAIGL P TMF GY IIC GVL L GP SGLNSIKSIVQV E T L G E F GV FFT LF L VGLEFS PEK L RK 346
Cdd:COG4651 3 ETPL I TT I AL I LG L AAVL G L L AQRLRQ P PIV GY LLA GVL I GP FTPGLVADVELI E Q L A E I GV ILL LF G VGLEFS LKD L LA 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 347 V W KI S L Q G PCYMTL L MIAF G LLWGH LL RIKPTQ S VFISTC LSLSST PLVSRF L mg SA RG dk E G D IDYSTVLL G M L VT QD V 426
Cdd:COG4651 83 V R KI A L P G ALLQIA L TTLL G FGIAL LL GWSLGE S LVFGLA LSLSST VVLLKL L -- ED RG -- E L D TLHGRIAV G W L IV QD L 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 427 QLG L FMAVM P T L IQA G AS asssivvevlr I L VLI G QI L FSL A AVFL L C LV IKKYL I GPYYRK lh MESKGNK E ILI L GIS A 506
Cdd:COG4651 159 AVV L MLVLL P A L AGG G GG ----------- L L GTL G LT L LKV A LFVA L M LV VGRRV I PWLLHR -- VARTRSR E LFL L AVL A 225
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 507 FIFLMLTVTE L LDV S ME LG C FLAG ALVSSQG pv VTEEI A TSIE P I RD FL A IV FF A S I G LHVF P T F VAYELTVLVF L T L S V 586
Cdd:COG4651 226 ICLGVAYLAA L FGL S FA LG A FLAG MVLAESE -- YSHQA A AELL P L RD AF A VL FF V S V G MLFD P S F LLENPLPVLA L L L I V 303
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 578825327 587 VVM K F L L A A L VLSLI lp RSSQYIKWI V SAG LAQ VS EFSF V L GSRARRA G VI S R E V Y L LI 645
Cdd:COG4651 304 LIG K P L I A F L IVLAL -- GYPLRTALL V GLS LAQ IG EFSF I L AALGLSL G LL S E E A Y Q LI 360
KefB
COG0475 Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism]; ...
268-645
1.71e-57
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism];
Pssm-ID: 440243 [Multi-domain]
Cd Length: 384
Bit Score: 199.22
E-value: 1.71e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 268 HHFIKDIVTIGMLSLPC G W L CTAI GLP TMF GYI IC G V LLGPSGL NS I KSIVQV E T L G E F GV FFT LFL V GLE FSPEK LRK V 347
Cdd:COG0475 3 ASLLLQLGLLLLAAVLA G L L ARRL GLP SVL GYI LA G I LLGPSGL GL I EDSEAL E L L A E L GV VLL LFL I GLE LDLKR LRK M 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 348 WKIS L QGPCYMT LL MIAF G L L WGH LL RIKPTQSV F ISTC L SLS ST PL V SRF L -- M G SARG dkegdi DYSTVL LG MLVTQ D 425
Cdd:COG0475 83 GRRA L GIGLLQV LL PFLL G F L LAL LL GLSLAAAL F LGAA L AAT ST AI V LKV L ke L G LLKT ------ PLGQLI LG VALFD D 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 426 VQLG L FM A VM P T L IQA G AS A S S sivvevlrilvl IGQI L FSLAAVFL L C L VIKK YL IGPYY R kl HMESKGNK E ILI L GIS 505
Cdd:COG0475 157 IAAI L LL A LV P A L AGG G SV A G S ------------ LLLA L LKALLFLA L L L LVGR YL LRRLF R -- LVARTRSR E LFL L FAL 222
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 506 AFIF L MLTVT ELL DV S ME LG C FLAG ALVSSQGPV vt E E IATS IEP IR D FLAIV FF A S I GL HVFPTFVAYELTVLVF L T L S 585
Cdd:COG0475 223 LLVL L AAALA ELL GL S AA LG A FLAG LVLAESEYR -- H E LEEK IEP FG D LFLPL FF V S V GL SLDLSALLSNPLLALL L V L A 300
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 586 VV V M K F L L A A L VLS L I lp RS S QYIKWIVSAG LA QVS EF SF VL G S RARR AG V IS R E VYLLI 645
Cdd:COG0475 301 AI V G K L L G A Y L AAR L F -- GL S RREALRIGLL LA PRG EF AL VL A S LGLS AG L IS P E LFAAL 358
Na_H_Exchanger
pfam00999 Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
274-645
4.85e-53
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.
Pssm-ID: 425982 [Multi-domain]
Cd Length: 377
Bit Score: 187.08
E-value: 4.85e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 274 IV TIGM L S L PCGW L CTAIG LP TMF G Y II C G V LLGPSGL NS I KSI - VQV E T L GEF G VFFT LFL V GLE FSPEK LRK VWKIS L 352
Cdd:pfam00999 1 IV LLIL L A L LAPL L ARRLK LP PIV G L II A G I LLGPSGL GL I SEV d EDL E V L SNL G LPPL LFL A GLE LDLRE LRK NGGSI L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 353 QGPCYMT L LMIAF -- G LL WGHL L R I KPTQSVFISTC LS LS S TPL V SRF L MGSA R GDK egdi DYS T V LLG ML V TQ D VQLGL 430
Cdd:pfam00999 81 LLALLGV L IPFVL ig L LL YLLG L G I PLLEALLFGAI LS AT S PVV V LAI L KELG R VPE ---- RLG T L LLG ES V LN D GVAVV 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 431 FM AV MPT L I Q AGASA S S sivvevlri L VLIGQ I LFSL A AVF LL CLVI kkyl IG PYY R KLHMESKGNK E ILI L GISAFIF L 510
Cdd:pfam00999 157 LL AV LLA L A Q GVGGG S D --------- L GWLLL I FLVV A VGG LL LGLL ---- IG WLL R LITRFTDDDR E LEV L LVLLLAL L 223
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 511 MLTVT E L L D VS ME LG C FLAG ALV S sq GPVVTEEIATSI EP IRDF L AI - V FF ASI GL HVFPTFVAYELTV LV F L T L SVVVM 589
Cdd:pfam00999 224 AALLA E A L G VS GI LG A FLAG LVL S -- EYPFANKLSEKL EP FGYG L FN p L FF VLV GL SLDLSSLLLSVWI LV L L A L VAILL 301
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 578825327 590 KFL L AALV L SLI L PR S SQY i KW I VSA G LA Q VSEF S FV L GSRARRA G V I S RE V Y L L I 645
Cdd:pfam00999 302 GRF L GVFL L LRL L GL S LRE - AL I IGF G GL Q RGAV S LA L AAIGPLL G I I A RE L Y P L L 356
2a37
TIGR00932 transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding ...
284-567
2.39e-32
transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273348 [Multi-domain]
Cd Length: 273
Bit Score: 126.22
E-value: 2.39e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 284 CGW L CTAI G L P TMF GY IIC GVL L GPSGL NS I KSIVQ V ET L G EFGV FFTL FL V GLE FSP E K L R K VW K ISL - Q G PCYMTLLM 362
Cdd:TIGR00932 7 AVP L SRRL G I P SVL GY LLA GVL I GPSGL GL I SNVEG V NH L A EFGV ILLM FL I GLE LDL E R L W K LR K AAF g V G VLQVLVPG 86
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 363 IAF GLL W GHLL RIKPTQS V F I STC L S LSST PL V SRF L mgsa RGDKEGDIDYSTVL LG M L VT QD VQLGLFM A VM P T L iqa G 442
Cdd:TIGR00932 87 VLL GLL L GHLL GLALGAA V V I GII L A LSST AV V VQV L ---- KERGLLKTPFGQTV LG I L LF QD IAVVPLL A LL P L L --- A 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 443 A SAS SS ivvevlri L V LIGQI L FSLAAV FLL CLVIKKY L IG P YY R KLH me SKGNK E ILIL G ISAFI F LMLTVTE LL DV SM 522
Cdd:TIGR00932 160 T SAS TE -------- H V ALALL L LKVFLA FLL LVLLGRW L LR P VL R LTA -- ELRPS E LFTA G SLLLM F GSAYFAD LL GL SM 229
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 578825327 523 E LG C FLAG ALV S SQ gp VVTEEIATSI EPI RDF L AIV FF A S I G LH V 567
Cdd:TIGR00932 230 A LG A FLAG VVL S ES -- EYRHKLESDL EPI GGV L LPL FF I S V G MS V 272
PRK03562
PRK03562 glutathione-regulated potassium-efflux system protein KefC; Provisional
290-640
1.31e-21
glutathione-regulated potassium-efflux system protein KefC; Provisional
Pssm-ID: 235131 [Multi-domain]
Cd Length: 621
Bit Score: 99.30
E-value: 1.31e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 290 AI GL PTMF GY I I C G VLL GP S GL NSIKSIVQVETLG EFGV FFT LF LV GLE FS P EK L rkv WK I -------- S LQ - GP C ym TL 360
Cdd:PRK03562 26 RL GL GSVL GY L I A G CII GP W GL RLVTDVESILHFA EFGV VLM LF VI GLE LD P QR L --- WK L rrsifggg A LQ m VA C -- GG 100
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 361 L MIA F GL L W G HLLRI kptq SVF I STC L S LSST P ----- LVS R F LM GSAR G DKE gdidystvl LGM L VT QD VQLGLFM A VM 435
Cdd:PRK03562 101 L LGL F CM L L G LRWQV ---- ALL I GLG L A LSST A iamqa MNE R N LM VTQM G RSA --------- FAI L LF QD IAAIPLV A MI 167
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 436 P T L IQA GAS - ASSSIVVEV L RILVLI gqilfsl A A V F L L clvi KK Y LIG P YY R kl HMESK G NK E I ------- L IL G ISA f 507
Cdd:PRK03562 168 P L L AAS GAS t TLGAFALSA L KVAGAL ------- A L V V L G ---- GR Y VTR P AL R -- FVARS G LR E V ftavalf L VF G FGL - 233
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 508 if LM ltvt E LLDV SM E LG C FLAG A L VS S qgpvv T E --- EIATS IEP IRDF L AIV FF ASI G LHV - F P T FVAYE L TV L VF L T 583
Cdd:PRK03562 234 -- LM ---- E EVGL SM A LG A FLAG V L LA S ----- S E yrh ALESD IEP FKGL L LGL FF IAV G MSI d F G T LLENP L RI L IL L L 302
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 578825327 584 LSVVVMKFL L AA L VLS L IL PR SSQ yik WIVSAG L A Q VS EF S FV LGSR A RR A G V ISR E 640
Cdd:PRK03562 303 GFLAIKIAM L WL L ARP L GV PR KQR --- RWFAVL L G Q GG EF A FV VFGA A QM A N V LEP E 356
PRK03659
PRK03659 glutathione-regulated potassium-efflux system protein KefB; Provisional
292-640
1.41e-20
glutathione-regulated potassium-efflux system protein KefB; Provisional
Pssm-ID: 179625 [Multi-domain]
Cd Length: 601
Bit Score: 96.25
E-value: 1.41e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 292 G LPTMF GY IIC G VLL GP S GL NS I KSIVQVETLG E F GV F F TL F LV GLE FS P E KL rkv W K is L QGP ------------- CYM 358
Cdd:PRK03659 28 G IGAVL GY LLA G IAI GP W GL GF I SDVDEILHFS E L GV V F LM F II GLE LN P S KL --- W Q -- L RRS ifgvgaaqvllsa AVL 102
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 359 TL L MIAFGLL W ghllrikp TQS V FISTC L SL SST PLVSRFLMGSARGDK E GDIDYST VLL gmlv T QD VQLGLFM A VM P T L 438
Cdd:PRK03659 103 AG L LMLTDFS W -------- QAA V VGGIG L AM SST AMALQLMREKGMNRS E SGQLGFS VLL ---- F QD LAVIPAL A LV P L L 170
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 439 iq AG ASASSSIVV evlrilvlig Q I LFSLA A VFLL c L VIKK YL IG P YY R kl HMESK G NK E I ------- L I LG ISA F I flm 511
Cdd:PRK03659 171 -- AG SADEHFDWM ---------- K I GMKVL A FAGM - L IGGR YL LR P LF R -- FIAAS G VR E V ftaaall L V LG SAL F M --- 232
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 512 ltvt EL L DV SM E LG C F L AG A L VSSQG pv VTE E IATS IEP IRDF L AIV FF A S I G LHV - FPTFVAYE L T VL VFLTLS V V V MK 590
Cdd:PRK03659 233 ---- DA L GL SM A LG T F I AG V L LAESE -- YRH E LEIA IEP FKGL L LGL FF I S V G MAL n LGVLYTHL L W VL ISVVVL V A V KG 306
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 578825327 591 FL L AA L VLSLI L p RSS QYIKW iv SAG L A Q VS EF S FVL G S R A RRAGVISRE 640
Cdd:PRK03659 307 LV L YL L ARLYG L - RSS ERMQF -- AGV L S Q GG EF A FVL F S A A SSQRLLQGD 353
PRK10669
PRK10669 putative cation:proton antiport protein; Provisional
268-627
1.27e-17
putative cation:proton antiport protein; Provisional
Pssm-ID: 182633 [Multi-domain]
Cd Length: 558
Bit Score: 86.69
E-value: 1.27e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 268 HH FIKD I V TI GM --- L SLPC G W L CTAIGLPTMF GY IIC GVL L GP SGLNSIKSIVQVET L G E F GV FFTL F L VGL E FS PEK L 344
Cdd:PRK10669 2 HH ATPL I T TI VG glv L AFIL G M L ANRLRISPLV GY LLA GVL A GP FTPGFVADTKLAPE L A E L GV ILLM F G VGL H FS LKD L 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 345 RK V WK I SLQ G PCYMTLLMIAF G LLWGHL L RIKPTQSVFIST CLS LS ST ----- P L VS R F L MG S A RG D kegdidyst VLL G 419
Cdd:PRK10669 82 MA V KS I AIP G AIAQIAVATLL G MALSAV L GWSLMTGIVFGL CLS TA ST vvllr A L EE R Q L ID S Q RG Q --------- IAI G 152
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 420 M L VTQ D VQLG L FMAVM P TLIQAGASASSSIVVEVLRILVL IG QIL fsla A VFLLCLVIKKY L IGPYYRK lh MESK G NK E I 499
Cdd:PRK10669 153 W L IVE D LVMV L TLVLL P AVAGMMEQGDVGFATLAVDLGIT IG KVI ---- A FIAIMMLVGRR L VPWILAR -- SAAT G SR E L 226
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 500 LI L GIS A FIF - LMLTVT EL L DVS ME LG C F L AG ALVSSQG pv VTEEI A TSIE P I RD FL A IV FF A S I G L h V F PTFVAYELTV 578
Cdd:PRK10669 227 FT L SVL A LAL g IAFGAV EL F DVS FA LG A F F AG MVLNESE -- LSHRA A HDTL P L RD AF A VL FF V S V G M - L F DPMILIQQPL 303
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 578825327 579 L V FL TL SVV V MKFL LAA LV L SLILPR S SQ y IKWIVS A G LAQ VS EF S F V L 627
Cdd:PRK10669 304 A V LA TL AII V FGKS LAA FF L VRLFGH S RR - TALTIA A S LAQ IG EF A F I L 351
PLN03159
PLN03159 cation/H(+) antiporter 15; Provisional
294-596
1.86e-05
cation/H(+) antiporter 15; Provisional
Pssm-ID: 215608 [Multi-domain]
Cd Length: 832
Bit Score: 47.96
E-value: 1.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 294 P TMFGY I IC GV L LGPS G L NSIK ---------- S IVQV ET LGEF G VFFT LFLVG L E FSPEKL R KVW K ---- I SLQ G PCYMT 359
Cdd:PLN03159 68 P RVISE I LG GV I LGPS V L GQSE vfantifplr S VMVL ET MANL G LLYF LFLVG V E MDISVI R RTG K kala I AIA G MALPF 147
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 360 LLMI AF GLLWGHLL R I -- KP T QSV F ISTC LS LSST P LVS R F L MGSARGDK E - G D I DY S TV L L gmlvt Q D VQLGLFM A VMP 436
Cdd:PLN03159 148 CIGL AF SFIFHQVS R N vh QG T FIL F LGVA LS VTAF P VLA R I L AEIKLINT E l G R I AM S AA L V ----- N D MCAWILL A LAI 222
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 437 T L IQAGASASS S ivvevlr IL VL IGQIL F S L A avfll C LVIKKYL I GPYY R KLH m E SKGNK E IL I LG I SAFIFLMLTV T E 516
Cdd:PLN03159 223 A L AENDSTSLA S ------- LW VL LSSVA F V L F ----- C FYVVRPG I WWII R RTP - E GETFS E FY I CL I LTGVMISGFI T D 289
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 517 LLDVSMEL G C F LA G a LV SSQ GP VVT eeia T S IE PIR DF ---- L AIV FFA SI GL HVFP T FVAYEL T ---- VLV FLTL S VV - 587
Cdd:PLN03159 290 AIGTHSVF G A F VF G - LV IPN GP LGV ---- T L IE KLE DF vsgl L LPL FFA IS GL KTNV T KIQGPA T wgll VLV IIMA S AG k 364
....*....
gi 578825327 588 V M KFLLA A L 596
Cdd:PLN03159 365 I M GTIII A F 373
NhaP
COG0025 NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
274-616
3.40e-04
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
Pssm-ID: 439796 [Multi-domain]
Cd Length: 506
Bit Score: 43.80
E-value: 3.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 274 I VTIGM L S L PCG WL CTAIG LP TMFGYIIC G V LLGP s GL NSI -- KSIVQV E T L G E FGVFFT LF LVG L EFSPEK LR KVWKIS 351
Cdd:COG0025 7 I LLLLL L G L LSQ WL ARRLK LP APLLLLLA G I LLGP - GL GLE ld PELGDL E P L L E LFLPPL LF EAA L NLDLRE LR RNGRPI 85
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 352 L Q --- GPCYM T L L MI A FGLL W gh LL RIKPTQSVFISTC L SLSSTPL VS R f LMGSARGD K E gdid YS T V L L G -------- M 420
Cdd:COG0025 86 L R lav VGVLL T T L AV A LAAH W -- LL GLPLAAALLLGAI L APTDPVA VS P - ILRRLGVP K R ---- LR T I L E G esllndat A 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 421 LV tqdvqlg LF MAVM p TLIQA G ASASSSIVVEV L ri L VLI G Q IL FS L AAVF LL CLVIK kyligpyyrkl HMESKGNKEI L 500
Cdd:COG0025 159 LV ------- LF VLAL - AAALG G GFSLGEALLDF L -- L AIL G G IL VG L LLGW LL GRLLR ----------- RLPDPLLEIL L 217
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825327 501 I L GISAFIF L mlt VT E L L DV S ME L GCFL AG ALVSSQ G PVVTE ei ATSIEPIRD F ------- L AIVF F ASI G LHV - FPTFV 572
Cdd:COG0025 218 T L ALPFLAY L --- LA E A L HG S GV L AVVV AG LVLGNA G RRSLS -- PETRLQLLE F wetlefl L NSLL F VLL G AQL p LILLG 292
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 578825327 573 A YE L TVLVFLT L SVV V MKF L LAA L V L S L ILP R S S QYIKWIV S A G 616
Cdd:COG0025 293 A LG L GGILLVL L ALL V VRP L WVF L S L A L RGS R L S WRERLFL S W G 336
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
