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Conserved domains on  [gi|578826526|ref|XP_006720427|]
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magnesium transporter NIPA2 isoform X1 [Homo sapiens]

Protein Classification

DMT family transporter( domain architecture ID 10529156)

DMT (drug/metabolite transporter) family transporter is an inner membrane protein involved in the transport of one or more of a variety of substrates such as amino acids, drugs, metabolites, and sugar phosphates, among others

Gene Ontology:  GO:0055085|GO:0005215|GO:0005886
PubMed:  11432728
TCDB:  2.A.7

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Mg_trans_NIPA pfam05653
Magnesium transporter NIPA; NIPA (nonimprinted in Prader-Willi/Angelman syndrome) is a family ...
8-302 8.73e-166

Magnesium transporter NIPA; NIPA (nonimprinted in Prader-Willi/Angelman syndrome) is a family of integral membrane proteins which function as magnesium transporters.


:

Pssm-ID: 398984  Cd Length: 295  Bit Score: 464.62  E-value: 8.73e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826526    8 YDFYIGLGLAMSSSIFIGGSFILKKKGLLRLARKGSMRAGQGGHAYLKEWLWWAGLLSMGAGEVANFAAYAFAPATLVTP 87
Cdd:pfam05653   1 TDFYIGVGLAISSSIFIGSSFIIKKKGLLRLARKGHPRAGAGGYGYLKEWLWWAGLLTMGVGEAANFAAYAFAPATLVTP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826526   88 LGALSVLVSAILSSYFLNERLNLHGKIGCLLSILGSTVMVIHAPKEEEIETLNEMSHKLGDPGFVVFATLVVIVALILIF 167
Cdd:pfam05653  81 LGALSVIISAVLASFFLKEKLNLSGKLGCVLCILGSTVIVIHAPKEQEIESLREVWHLLTDPGFLVYVILVVGVVLALIL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826526  168 VVGPRHGQTNILVYITICSVIGAFSVSCVKGLGIAIKELFAGKPVLRHPLAWILLLSLIVCVSTQINYLNRALDIFNTSI 247
Cdd:pfam05653 161 YFEPRHGQTNIVVYITICSLIGSLTVMSVKAVGIAIKLTFTGKNQLTYPIAWILLLVMITCCVTQINYLNKALDIFNTSI 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 578826526  248 VTPIYYVFFTTSVLTCSAILFKEWQDMPVDDVIGTLSGFFTIIVGIFLLHAFKDV 302
Cdd:pfam05653 241 VTPVYYVMFTTSVIIASAILFKEWLGMAFLDVAGELCGFFTVITGVFLLHAFRDK 295
 
Name Accession Description Interval E-value
Mg_trans_NIPA pfam05653
Magnesium transporter NIPA; NIPA (nonimprinted in Prader-Willi/Angelman syndrome) is a family ...
8-302 8.73e-166

Magnesium transporter NIPA; NIPA (nonimprinted in Prader-Willi/Angelman syndrome) is a family of integral membrane proteins which function as magnesium transporters.


Pssm-ID: 398984  Cd Length: 295  Bit Score: 464.62  E-value: 8.73e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826526    8 YDFYIGLGLAMSSSIFIGGSFILKKKGLLRLARKGSMRAGQGGHAYLKEWLWWAGLLSMGAGEVANFAAYAFAPATLVTP 87
Cdd:pfam05653   1 TDFYIGVGLAISSSIFIGSSFIIKKKGLLRLARKGHPRAGAGGYGYLKEWLWWAGLLTMGVGEAANFAAYAFAPATLVTP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826526   88 LGALSVLVSAILSSYFLNERLNLHGKIGCLLSILGSTVMVIHAPKEEEIETLNEMSHKLGDPGFVVFATLVVIVALILIF 167
Cdd:pfam05653  81 LGALSVIISAVLASFFLKEKLNLSGKLGCVLCILGSTVIVIHAPKEQEIESLREVWHLLTDPGFLVYVILVVGVVLALIL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826526  168 VVGPRHGQTNILVYITICSVIGAFSVSCVKGLGIAIKELFAGKPVLRHPLAWILLLSLIVCVSTQINYLNRALDIFNTSI 247
Cdd:pfam05653 161 YFEPRHGQTNIVVYITICSLIGSLTVMSVKAVGIAIKLTFTGKNQLTYPIAWILLLVMITCCVTQINYLNKALDIFNTSI 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 578826526  248 VTPIYYVFFTTSVLTCSAILFKEWQDMPVDDVIGTLSGFFTIIVGIFLLHAFKDV 302
Cdd:pfam05653 241 VTPVYYVMFTTSVIIASAILFKEWLGMAFLDVAGELCGFFTVITGVFLLHAFRDK 295
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
57-296 1.59e-07

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 52.15  E-value: 1.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826526  57 WLWWAGLLSMGAGEVANFAAYAFAPATLVTPLGALSVLVSAILSSYFLNERLNLHGKIGCLLSILGSTVMVIHapkeeei 136
Cdd:COG0697   67 LLLLRGLLGLALAFLLFFLALQYTPAALAALLLALAPLFVALLAALLLGERLSRRRWLGLLLGFAGVLLIVGP------- 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826526 137 ETLNEMSHKLGDpGFVVFATLVVIVALILIFVVGPRHGQTNILVYITICSVIGAFSVScvkglgiaikeLFAGKPVLRHP 216
Cdd:COG0697  140 GGGGGGGSLLGD-LLALLAALSWALYTVLTRRLSRRLDPLTLTFWQMLVGALLLLPLA-----------LLTGLPLPLSA 207
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826526 217 LAWILLLsLIVCVSTQINYL--NRALDIFNTSIVTPIYYVFFTTSVLTcSAILFKEWQDmpvddvIGTLSGFFTIIVGIF 294
Cdd:COG0697  208 AAWLALL-YLGLFGTALAYLlwFRALRRLGASRAAPLTYLEPVFAVLL-GWLLLGEPLT------PLQLLGAALILAGVL 279

                 ..
gi 578826526 295 LL 296
Cdd:COG0697  280 LA 281
 
Name Accession Description Interval E-value
Mg_trans_NIPA pfam05653
Magnesium transporter NIPA; NIPA (nonimprinted in Prader-Willi/Angelman syndrome) is a family ...
8-302 8.73e-166

Magnesium transporter NIPA; NIPA (nonimprinted in Prader-Willi/Angelman syndrome) is a family of integral membrane proteins which function as magnesium transporters.


Pssm-ID: 398984  Cd Length: 295  Bit Score: 464.62  E-value: 8.73e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826526    8 YDFYIGLGLAMSSSIFIGGSFILKKKGLLRLARKGSMRAGQGGHAYLKEWLWWAGLLSMGAGEVANFAAYAFAPATLVTP 87
Cdd:pfam05653   1 TDFYIGVGLAISSSIFIGSSFIIKKKGLLRLARKGHPRAGAGGYGYLKEWLWWAGLLTMGVGEAANFAAYAFAPATLVTP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826526   88 LGALSVLVSAILSSYFLNERLNLHGKIGCLLSILGSTVMVIHAPKEEEIETLNEMSHKLGDPGFVVFATLVVIVALILIF 167
Cdd:pfam05653  81 LGALSVIISAVLASFFLKEKLNLSGKLGCVLCILGSTVIVIHAPKEQEIESLREVWHLLTDPGFLVYVILVVGVVLALIL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826526  168 VVGPRHGQTNILVYITICSVIGAFSVSCVKGLGIAIKELFAGKPVLRHPLAWILLLSLIVCVSTQINYLNRALDIFNTSI 247
Cdd:pfam05653 161 YFEPRHGQTNIVVYITICSLIGSLTVMSVKAVGIAIKLTFTGKNQLTYPIAWILLLVMITCCVTQINYLNKALDIFNTSI 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 578826526  248 VTPIYYVFFTTSVLTCSAILFKEWQDMPVDDVIGTLSGFFTIIVGIFLLHAFKDV 302
Cdd:pfam05653 241 VTPVYYVMFTTSVIIASAILFKEWLGMAFLDVAGELCGFFTVITGVFLLHAFRDK 295
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
57-296 1.59e-07

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 52.15  E-value: 1.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826526  57 WLWWAGLLSMGAGEVANFAAYAFAPATLVTPLGALSVLVSAILSSYFLNERLNLHGKIGCLLSILGSTVMVIHapkeeei 136
Cdd:COG0697   67 LLLLRGLLGLALAFLLFFLALQYTPAALAALLLALAPLFVALLAALLLGERLSRRRWLGLLLGFAGVLLIVGP------- 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826526 137 ETLNEMSHKLGDpGFVVFATLVVIVALILIFVVGPRHGQTNILVYITICSVIGAFSVScvkglgiaikeLFAGKPVLRHP 216
Cdd:COG0697  140 GGGGGGGSLLGD-LLALLAALSWALYTVLTRRLSRRLDPLTLTFWQMLVGALLLLPLA-----------LLTGLPLPLSA 207
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826526 217 LAWILLLsLIVCVSTQINYL--NRALDIFNTSIVTPIYYVFFTTSVLTcSAILFKEWQDmpvddvIGTLSGFFTIIVGIF 294
Cdd:COG0697  208 AAWLALL-YLGLFGTALAYLlwFRALRRLGASRAAPLTYLEPVFAVLL-GWLLLGEPLT------PLQLLGAALILAGVL 279

                 ..
gi 578826526 295 LL 296
Cdd:COG0697  280 LA 281
RibN COG2510
Riboflavin transporter RibN, EamA domain [Coenzyme transport and metabolism];
59-128 4.29e-06

Riboflavin transporter RibN, EamA domain [Coenzyme transport and metabolism];


Pssm-ID: 442000  Cd Length: 138  Bit Score: 45.56  E-value: 4.29e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578826526  59 WWAGLLS---MGAGEVANFAAYAFAPATLVTPLGALSVLVSAILSSYFLNERLNLHGKIGCLLSILGSTVMVI 128
Cdd:COG2510   65 WLFLLLSglaTGLSWLFYFRALKLGPASIVAPIDKLSPVFTVLLSVLFLGERLTLKQIIGILLIVAGVILLSL 137
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
54-128 3.72e-05

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 42.95  E-value: 3.72e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578826526   54 LKEWLWWA--GLLSMGAGEVANFAAYAFAPATLVTPLGALSVLVSAILSSYFLNERLNLHGKIGCLLSILGSTVMVI 128
Cdd:pfam00892  60 LKSWLALLylGVLGTFLGFLLYFYGLKYVSASNASVITSLSPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLLILL 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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