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Conserved domains on  [gi|578827668|ref|XP_006720856|]
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solute carrier family 12 member 6 isoform X1 [Homo sapiens]

Protein Classification

solute carrier family 12 protein( domain architecture ID 11489985)

solute carrier family 12 protein similar to Arabidopsis thaliana cation-chloride cotransporter 1, which mediates both potassium-chloride and sodium-chloride cotransports and is involved in plant development and Cl(-) homeostasis

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
109-1101 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


:

Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1244.22  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   109 HKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTK------- 181
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDAEGTKEKPPAgavkfgw 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   182 -------------------------------------------TMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGA 218
Cdd:TIGR00930   81 vmgvlvpcllniwgvilflrlswivgqagiglslliillcccvTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   219 VGLCFYLGTTFAAAMYILGAIEIFLvyivpraAIFHSDdALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLF 298
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVL-------DLLREN-GSKIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLF 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   299 LACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTlssrhidvcsktkeinnmtvpsklwgffcnssqffnatcdeyFVHN 378
Cdd:TIGR00930  233 LVIVLLSILNIFVGTIIPAFDKPAKGFFGLGNEI------------------------------------------FSEN 270
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   379 NvtsIQGIPGLASGiitenlwsnylpkgeiiekpsakssdvlgslnheyvlvdittsFTLLVGIFFPSVTGIMAGSNRSG 458
Cdd:TIGR00930  271 F---IPGIPGPEGG-------------------------------------------FFSLFGIFFPSVTGILAGANISG 304
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   459 DLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVK---------------------GNLVVGTLSW 517
Cdd:TIGR00930  305 DLKDPQKAIPKGTLLAILTTTVVYLGSVVLFGACVVRDATGDKNDTLVTnctsaacfsecahntcsyglmNNLQVMSLVS 384
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   518 PSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTAAIAELGILIASLDLVAPI 596
Cdd:TIGR00930  385 PFPPLITAGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGkNGEPLRAYLLTAFIAEGFILIAELNTIAPI 464
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   597 LSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKE 676
Cdd:TIGR00930  465 ISNFFLASYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVN 544
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   677 WGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDedlhVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYG 756
Cdd:TIGR00930  545 WGSSTQALSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPP----VCRPALLDFASQFTKGKGLMICGSVIQGPRLECVK 620
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   757 EALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEdARAWKTFIGTVRVTTA 836
Cdd:TIGR00930  621 EAQAAEAKIQTWLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAE-PRAWETYIGIIHDAFD 699
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   837 AHLALLVAKNISFFPSNV--------------------------------------EQFSEGNIDVWWIVHDGGMLMLLP 878
Cdd:TIGR00930  700 AHLAVVVVRNSEGLPISVlqvqeelendcsedsielndgkistqpdmhleastqfqKKQGKGTIDVWWLVDDGGLTLLLP 779
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   879 FLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMhdsDISAytYERTLMMEQRSQMLRHMRLS 958
Cdd:TIGR00930  780 YLLTTKKVWKKCKIRIFVGAQKDDRSEQEKKDMATLLYKFRIDAEVIVVLM---DINA--KPQTESMEAFEEMIRPFRLH 854
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   959 KTERDREAqlvKDRnsmlrltsigsdedeetetyqekvHMTWTKDKYMASrgqkaksmegfQDLlnmrpdQSNVRRMHTA 1038
Cdd:TIGR00930  855 KTEKDREA---KDP------------------------KMTWTKPWKITD-----------AEL------QSNVRKSYRQ 890
                         1050      1060      1070      1080      1090      1100
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578827668  1039 VKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1101
Cdd:TIGR00930  891 VRLNELLLEYSRDAALVVLSLPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
109-1101 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1244.22  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   109 HKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTK------- 181
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDAEGTKEKPPAgavkfgw 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   182 -------------------------------------------TMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGA 218
Cdd:TIGR00930   81 vmgvlvpcllniwgvilflrlswivgqagiglslliillcccvTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   219 VGLCFYLGTTFAAAMYILGAIEIFLvyivpraAIFHSDdALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLF 298
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVL-------DLLREN-GSKIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLF 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   299 LACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTlssrhidvcsktkeinnmtvpsklwgffcnssqffnatcdeyFVHN 378
Cdd:TIGR00930  233 LVIVLLSILNIFVGTIIPAFDKPAKGFFGLGNEI------------------------------------------FSEN 270
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   379 NvtsIQGIPGLASGiitenlwsnylpkgeiiekpsakssdvlgslnheyvlvdittsFTLLVGIFFPSVTGIMAGSNRSG 458
Cdd:TIGR00930  271 F---IPGIPGPEGG-------------------------------------------FFSLFGIFFPSVTGILAGANISG 304
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   459 DLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVK---------------------GNLVVGTLSW 517
Cdd:TIGR00930  305 DLKDPQKAIPKGTLLAILTTTVVYLGSVVLFGACVVRDATGDKNDTLVTnctsaacfsecahntcsyglmNNLQVMSLVS 384
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   518 PSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTAAIAELGILIASLDLVAPI 596
Cdd:TIGR00930  385 PFPPLITAGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGkNGEPLRAYLLTAFIAEGFILIAELNTIAPI 464
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   597 LSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKE 676
Cdd:TIGR00930  465 ISNFFLASYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVN 544
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   677 WGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDedlhVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYG 756
Cdd:TIGR00930  545 WGSSTQALSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPP----VCRPALLDFASQFTKGKGLMICGSVIQGPRLECVK 620
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   757 EALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEdARAWKTFIGTVRVTTA 836
Cdd:TIGR00930  621 EAQAAEAKIQTWLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAE-PRAWETYIGIIHDAFD 699
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   837 AHLALLVAKNISFFPSNV--------------------------------------EQFSEGNIDVWWIVHDGGMLMLLP 878
Cdd:TIGR00930  700 AHLAVVVVRNSEGLPISVlqvqeelendcsedsielndgkistqpdmhleastqfqKKQGKGTIDVWWLVDDGGLTLLLP 779
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   879 FLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMhdsDISAytYERTLMMEQRSQMLRHMRLS 958
Cdd:TIGR00930  780 YLLTTKKVWKKCKIRIFVGAQKDDRSEQEKKDMATLLYKFRIDAEVIVVLM---DINA--KPQTESMEAFEEMIRPFRLH 854
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   959 KTERDREAqlvKDRnsmlrltsigsdedeetetyqekvHMTWTKDKYMASrgqkaksmegfQDLlnmrpdQSNVRRMHTA 1038
Cdd:TIGR00930  855 KTEKDREA---KDP------------------------KMTWTKPWKITD-----------AEL------QSNVRKSYRQ 890
                         1050      1060      1070      1080      1090      1100
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578827668  1039 VKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1101
Cdd:TIGR00930  891 VRLNELLLEYSRDAALVVLSLPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
AA_permease pfam00324
Amino acid permease;
182-711 3.73e-39

Amino acid permease;


Pssm-ID: 366028 [Multi-domain]  Cd Length: 467  Bit Score: 152.47  E-value: 3.73e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   182 TMLTAISMSAIATNGVVpAGGSYFMISRALGPEFGGAVGL--CFYLGTTFAAAmyiLGAIEIFLVYIVPRAAIfhsddal 259
Cdd:pfam00324   42 IFLVMLSLGEISTNGPV-SGGFYTYASRFLGPSLGFATGWnyWLSWITVLALE---LTAASILIQFWELVPDI------- 110
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   260 kesaamlNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAI--KSSFAPPHFPVcmlgnrtlssrh 337
Cdd:pfam00324  111 -------PYLWVWGAVFLVLLTIINLVGVKWYGEAEFWFALIKIIAIIGFIIVGIilLSGGNPNDGAI------------ 171
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   338 idvcsktkeinnmtvpsklwgffcnssqffnatcdEYFVHNNVTSIQGIPGLASGIItenlwsnylpkgeiiekpsakss 417
Cdd:pfam00324  172 -----------------------------------FRYLGDNGGKNNFPPGFGKGFI----------------------- 193
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   418 dvlgslnheYVLVdittsftllvgIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEG-- 495
Cdd:pfam00324  194 ---------SVFV-----------IAFFAFTGIELVGIAAGEVKNPEKSIPKAILQVIWRITIFYILSLLAIGLLVPWnd 253
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   496 VVLRDKFGDAVKGNLVVGTLSWPS--PWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFlrVFGHSKANGEPTWA 573
Cdd:pfam00324  254 PGLLNDSASAASPFVIFFKFLGISglAPLINAVILTAALSAANSSLYSGSRMLYSLARDGLAPK--FLKKVDKRGVPLRA 331
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   574 LLLTAAIAELGILIASLdlVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYY 653
Cdd:pfam00324  332 ILVSMVISLLALLLASL--NPAIVFNFLLAISGLSGLIVWGLISLSHLRFRKAFKYQGRSIDELPFKAPLGPLGVILGLA 409
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 578827668   654 AIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLL 711
Cdd:pfam00324  410 AIIIILIIQFLYAFLPVPGGPKNWGAGSFAAAYLIVLLFLIILIGVKLHVKNWKPQLL 467
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
182-671 2.55e-33

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 134.25  E-value: 2.55e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668  182 TMLTAISMSAIATNgvVP-AGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEiFLVYIVPRAAIFhsddalk 260
Cdd:COG0531    57 ALLVALSYAELASA--FPrAGGAYTYARRALGPLLGFLAGWALLLSYVLAVAAVAVAFGG-YLSSLFPAGGSV------- 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668  261 esaamlnnmrVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIkSSFAPPHFpvcmlgnrtlssrhidv 340
Cdd:COG0531   127 ----------LIALVLILLLTLLNLRGVKESAKVNNILTVLKLLVLLLFIVVGL-FAFDPANF----------------- 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668  341 csktkeinnmtvpsklwgffcnsSQFFNATcdeyfvhnnvtsiQGIPGLASGIitenlwsnylpkgeiiekpsakssdvl 420
Cdd:COG0531   179 -----------------------TPFLPAG-------------GGLSGVLAAL--------------------------- 195
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668  421 gslnheyvlvdittsftllvGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYlsnvVLFGACIEGVVLRD 500
Cdd:COG0531   196 --------------------ALAFFAFTGFEAIANLAEEAKNPKRNIPRAIILSLLIVGVLY----ILVSLALTGVVPYD 251
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668  501 KFGDAVKGNLVVGTLSWPSP--WVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPflRVFGH-SKANGEPTWALLLT 577
Cdd:COG0531   252 ELAASGAPLADAAEAVFGPWgaILIALGALLSLLGALNASILGASRLLYAMARDGLLP--KVFAKvHPRFGTPVNAILLT 329
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668  578 AAIAELGILI--ASLDLVAPILSMFFLMCYLFVNLAcALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFIS---SWY 652
Cdd:COG0531   330 GVIALLLLLLgaASFTALASLASVGVLLAYLLVALA-VIVLRRRRPDLPRPFRVPLPLIPILGILLCLFLLYLLgpgALL 408
                         490
                  ....*....|....*....
gi 578827668  653 YAIVAMVIAGMIYKYIEYQ 671
Cdd:COG0531   409 IGLVLLAIGLLLYLLYRRR 427
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
109-1101 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1244.22  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   109 HKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTK------- 181
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDAEGTKEKPPAgavkfgw 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   182 -------------------------------------------TMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGA 218
Cdd:TIGR00930   81 vmgvlvpcllniwgvilflrlswivgqagiglslliillcccvTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   219 VGLCFYLGTTFAAAMYILGAIEIFLvyivpraAIFHSDdALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLF 298
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVL-------DLLREN-GSKIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLF 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   299 LACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTlssrhidvcsktkeinnmtvpsklwgffcnssqffnatcdeyFVHN 378
Cdd:TIGR00930  233 LVIVLLSILNIFVGTIIPAFDKPAKGFFGLGNEI------------------------------------------FSEN 270
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   379 NvtsIQGIPGLASGiitenlwsnylpkgeiiekpsakssdvlgslnheyvlvdittsFTLLVGIFFPSVTGIMAGSNRSG 458
Cdd:TIGR00930  271 F---IPGIPGPEGG-------------------------------------------FFSLFGIFFPSVTGILAGANISG 304
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   459 DLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVK---------------------GNLVVGTLSW 517
Cdd:TIGR00930  305 DLKDPQKAIPKGTLLAILTTTVVYLGSVVLFGACVVRDATGDKNDTLVTnctsaacfsecahntcsyglmNNLQVMSLVS 384
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   518 PSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTAAIAELGILIASLDLVAPI 596
Cdd:TIGR00930  385 PFPPLITAGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGkNGEPLRAYLLTAFIAEGFILIAELNTIAPI 464
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   597 LSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKE 676
Cdd:TIGR00930  465 ISNFFLASYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVN 544
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   677 WGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDedlhVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYG 756
Cdd:TIGR00930  545 WGSSTQALSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPP----VCRPALLDFASQFTKGKGLMICGSVIQGPRLECVK 620
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   757 EALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEdARAWKTFIGTVRVTTA 836
Cdd:TIGR00930  621 EAQAAEAKIQTWLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAE-PRAWETYIGIIHDAFD 699
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   837 AHLALLVAKNISFFPSNV--------------------------------------EQFSEGNIDVWWIVHDGGMLMLLP 878
Cdd:TIGR00930  700 AHLAVVVVRNSEGLPISVlqvqeelendcsedsielndgkistqpdmhleastqfqKKQGKGTIDVWWLVDDGGLTLLLP 779
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   879 FLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMhdsDISAytYERTLMMEQRSQMLRHMRLS 958
Cdd:TIGR00930  780 YLLTTKKVWKKCKIRIFVGAQKDDRSEQEKKDMATLLYKFRIDAEVIVVLM---DINA--KPQTESMEAFEEMIRPFRLH 854
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   959 KTERDREAqlvKDRnsmlrltsigsdedeetetyqekvHMTWTKDKYMASrgqkaksmegfQDLlnmrpdQSNVRRMHTA 1038
Cdd:TIGR00930  855 KTEKDREA---KDP------------------------KMTWTKPWKITD-----------AEL------QSNVRKSYRQ 890
                         1050      1060      1070      1080      1090      1100
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578827668  1039 VKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1101
Cdd:TIGR00930  891 VRLNELLLEYSRDAALVVLSLPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
AA_permease pfam00324
Amino acid permease;
182-711 3.73e-39

Amino acid permease;


Pssm-ID: 366028 [Multi-domain]  Cd Length: 467  Bit Score: 152.47  E-value: 3.73e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   182 TMLTAISMSAIATNGVVpAGGSYFMISRALGPEFGGAVGL--CFYLGTTFAAAmyiLGAIEIFLVYIVPRAAIfhsddal 259
Cdd:pfam00324   42 IFLVMLSLGEISTNGPV-SGGFYTYASRFLGPSLGFATGWnyWLSWITVLALE---LTAASILIQFWELVPDI------- 110
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   260 kesaamlNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAI--KSSFAPPHFPVcmlgnrtlssrh 337
Cdd:pfam00324  111 -------PYLWVWGAVFLVLLTIINLVGVKWYGEAEFWFALIKIIAIIGFIIVGIilLSGGNPNDGAI------------ 171
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   338 idvcsktkeinnmtvpsklwgffcnssqffnatcdEYFVHNNVTSIQGIPGLASGIItenlwsnylpkgeiiekpsakss 417
Cdd:pfam00324  172 -----------------------------------FRYLGDNGGKNNFPPGFGKGFI----------------------- 193
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   418 dvlgslnheYVLVdittsftllvgIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEG-- 495
Cdd:pfam00324  194 ---------SVFV-----------IAFFAFTGIELVGIAAGEVKNPEKSIPKAILQVIWRITIFYILSLLAIGLLVPWnd 253
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   496 VVLRDKFGDAVKGNLVVGTLSWPS--PWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFlrVFGHSKANGEPTWA 573
Cdd:pfam00324  254 PGLLNDSASAASPFVIFFKFLGISglAPLINAVILTAALSAANSSLYSGSRMLYSLARDGLAPK--FLKKVDKRGVPLRA 331
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   574 LLLTAAIAELGILIASLdlVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYY 653
Cdd:pfam00324  332 ILVSMVISLLALLLASL--NPAIVFNFLLAISGLSGLIVWGLISLSHLRFRKAFKYQGRSIDELPFKAPLGPLGVILGLA 409
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 578827668   654 AIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLL 711
Cdd:pfam00324  410 AIIIILIIQFLYAFLPVPGGPKNWGAGSFAAAYLIVLLFLIILIGVKLHVKNWKPQLL 467
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
182-671 2.55e-33

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 134.25  E-value: 2.55e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668  182 TMLTAISMSAIATNgvVP-AGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEiFLVYIVPRAAIFhsddalk 260
Cdd:COG0531    57 ALLVALSYAELASA--FPrAGGAYTYARRALGPLLGFLAGWALLLSYVLAVAAVAVAFGG-YLSSLFPAGGSV------- 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668  261 esaamlnnmrVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIkSSFAPPHFpvcmlgnrtlssrhidv 340
Cdd:COG0531   127 ----------LIALVLILLLTLLNLRGVKESAKVNNILTVLKLLVLLLFIVVGL-FAFDPANF----------------- 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668  341 csktkeinnmtvpsklwgffcnsSQFFNATcdeyfvhnnvtsiQGIPGLASGIitenlwsnylpkgeiiekpsakssdvl 420
Cdd:COG0531   179 -----------------------TPFLPAG-------------GGLSGVLAAL--------------------------- 195
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668  421 gslnheyvlvdittsftllvGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYlsnvVLFGACIEGVVLRD 500
Cdd:COG0531   196 --------------------ALAFFAFTGFEAIANLAEEAKNPKRNIPRAIILSLLIVGVLY----ILVSLALTGVVPYD 251
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668  501 KFGDAVKGNLVVGTLSWPSP--WVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPflRVFGH-SKANGEPTWALLLT 577
Cdd:COG0531   252 ELAASGAPLADAAEAVFGPWgaILIALGALLSLLGALNASILGASRLLYAMARDGLLP--KVFAKvHPRFGTPVNAILLT 329
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668  578 AAIAELGILI--ASLDLVAPILSMFFLMCYLFVNLAcALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFIS---SWY 652
Cdd:COG0531   330 GVIALLLLLLgaASFTALASLASVGVLLAYLLVALA-VIVLRRRRPDLPRPFRVPLPLIPILGILLCLFLLYLLgpgALL 408
                         490
                  ....*....|....*....
gi 578827668  653 YAIVAMVIAGMIYKYIEYQ 671
Cdd:COG0531   409 IGLVLLAIGLLLYLLYRRR 427
SLC12 pfam03522
Solute carrier family 12;
725-1101 7.56e-31

Solute carrier family 12;


Pssm-ID: 460955  Cd Length: 414  Bit Score: 126.58  E-value: 7.56e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   725 PRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEqtIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKH 804
Cdd:pfam03522    2 PALVDFAHLITKNVSLMICGHVVKGRLSQKLRSELQKK--AYRWLRKRKIKAFYALVDGDNLREGAQALLQASGLGKLKP 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   805 NTVVMGWPNGWRQSE------------DA--------------------------------------------------- 821
Cdd:pfam03522   80 NILLMGYKSDWRTCDkeeleeyfnvihDAfdlqyavailrlpegldvshllqdqdteelglgdetnssyaeqsseeqsts 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   822 --RAWKTFIGTVRVTTAAHLALLV-------------------AKNISFFPSNVE--------QF----SEGNIDVWWIV 868
Cdd:pfam03522  160 nsKQDDDKSKLSKKDSNLSLSPDKstknpsgkdssksdklkkkSPSIILRTASNEkeilnnitQFqkkqKKGTIDVWWLY 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   869 HDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIE-AEVEVVemhdSDISAYTYERTLMMEQ 947
Cdd:pfam03522  240 DDGGLTLLLPYILSTRSKWSDCKLRVFALGNRKDELEEEQRNMASLLSKFRIDySDLTVI----PDITKKPKKETKKFFD 315
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   948 rsQMLRHMRLSKTERDREaqlvkdrnSMLRLTsigsdeDEETETYQEKVHmtwtkdkymasrgqkaksmegfqdlLNMRp 1027
Cdd:pfam03522  316 --ELIEPFRLHEDDKEEE--------SAEKIT------DSELEALKEKTN-------------------------RQLR- 353
                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578827668  1028 dqsnvrrmhtavkLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1101
Cdd:pfam03522  354 -------------LRELLLEHSSDANLIVMTLPMPRKGTVSAPLYMAWLETLTKDLPPFLLVRGNQTSVLTFYS 414
AA_permease_2 pfam13520
Amino acid permease;
432-668 2.61e-15

Amino acid permease;


Pssm-ID: 404414 [Multi-domain]  Cd Length: 427  Bit Score: 79.66  E-value: 2.61e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   432 ITTSFTLLVGIFFpSVTGIMAGSNRSGDLKdaQKSIPIGTILAILTTSFVY-LSNVVLFGAC-IEGVVLRDKFGD---AV 506
Cdd:pfam13520  187 WPGVFAGFLGVLW-SFTGFESAANVSEEVK--KRNVPKAIFIGVIIVGVLYiLVNIAFFGVVpDDEIALSSGLGQvaaLL 263
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   507 KGNLVVGTLSWpspwVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGIL 586
Cdd:pfam13520  264 FQAVGGKWGAI----IVVILLALSLLGAVNTAIVGASRLLYALARDGVLPFSRFFAKVNKFGSPIRAIILTAILSLILLL 339
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   587 IASLDLVAPI----LSMFFLMCYLFVNLACALqtLLRTPNWRPRFRYYHWALSFMGMsICLALMFISSWYYAIVAMVIAG 662
Cdd:pfam13520  340 LFLLSPAAYNallsLSAYGYLLSYLLPIIGLL--ILRKKRPDLGRIPGRWPVAIFGI-LFSLFLIVALFFPPVGPATGSS 416

                   ....*.
gi 578827668   663 MIYKYI 668
Cdd:pfam13520  417 LNYAII 422
2A0308 TIGR00911
L-type amino acid transporter; [Transport and binding proteins, Amino acids, peptides and ...
458-657 3.70e-05

L-type amino acid transporter; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273332 [Multi-domain]  Cd Length: 501  Bit Score: 47.82  E-value: 3.70e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   458 GDLKDAQKSIPIGTILAILTTSFVY-LSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPwvIVIGsfFSTCGAGL 536
Cdd:TIGR00911  259 EEVKNPYRTLPIAIIISMPIVTFIYvLTNIAYFTVLSPEELLASLAVAVDFGERLLGVMSWAMP--ALVG--LSCFGSVN 334
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578827668   537 QSLTGAPRLLQAIAKDNIIPFLRVFGHSKANgEPTWALLLTAAIAELGILIASLDLVAPILSMFFlmcYLFVNLACALQT 616
Cdd:TIGR00911  335 GSLFSSSRLFFVGGREGHLPSLLSMIHVKRL-TPLPSLLIVCTLTLLMLFSGDIYSLINLISFAN---WLFNALAVAGLL 410
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 578827668   617 LLR--TPNWRPRFRyyhwalsfmgMSICLALMFISSWYYAIVA 657
Cdd:TIGR00911  411 WLRykRPEMNRPIK----------VPLFFPVFFLLSCLFLIIL 443
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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