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Conserved domains on  [gi|578832285|ref|XP_006722437|]
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CD226 antigen isoform X3 [Homo sapiens]

Protein Classification

immunoglobulin domain-containing family protein( domain architecture ID 34076)

immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 17-99 4.11e-06

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05716:

Pssm-ID: 472250  Cd Length: 100  Bit Score: 43.93  E-value: 4.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832285  17 IVSEPGKNVTLTCQPQMTWPVQAVRWEKIQPrqidllTYCN-LVHGRNFTSKFPRQIVSNCSHGRWSViVIPDVTVSDSG 95
Cdd:cd05716    7 VTGVEGGSVTIQCPYPPKYASSRKYWCKWGS------EGCQtLVSSEGVVPGGRISLTDDPDNGVFTV-TLNQLRKEDAG 79


                 ....
gi 578832285  96 LYRC 99
Cdd:cd05716   80 WYWC 83
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 17-99 4.11e-06

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 43.93  E-value: 4.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832285  17 IVSEPGKNVTLTCQPQMTWPVQAVRWEKIQPrqidllTYCN-LVHGRNFTSKFPRQIVSNCSHGRWSViVIPDVTVSDSG 95
Cdd:cd05716    7 VTGVEGGSVTIQCPYPPKYASSRKYWCKWGS------EGCQtLVSSEGVVPGGRISLTDDPDNGVFTV-TLNQLRKEDAG 79


                 ....
gi 578832285  96 LYRC 99
Cdd:cd05716   80 WYWC 83
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 15-117 1.23e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.11  E-value: 1.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832285    15 SHIVSEPGKNVTLTCQ------PQMTWpvqavRWEKIQPrqidlltycnLVHGRNFTSKfprqivsncSHGRWSVIVIPD 88
Cdd:smart00410   2 PSVTVKEGESVTLSCEasgsppPEVTW-----YKQGGKL----------LAESGRFSVS---------RSGSTSTLTISN 57

                           90       100
                   ....*....|....*....|....*....
gi 578832285    89 VTVSDSGLYRCYLQASAGENETFVmRLTV 117
Cdd:smart00410  58 VTPEDSGTYTCAATNSSGSASSGT-TLTV 85
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 22-117 6.59e-05

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 40.90  E-value: 6.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832285   22 GKNVTLTCQ--PQMTWPVQAVRWEKiQPRQIDLLTYCNLVHGRNFTSKFPRQIVSNCSHGRWSV-IVIPDVTVSDSGLYR 98
Cdd:pfam07686  11 GGSVTLPCTysSSMSEASTSVYWYR-QPPGKGPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGsLTIQNLTLSDSGTYT 89

                          90
                  ....*....|....*....
gi 578832285   99 CYLQASAGENETFVMRLTV 117
Cdd:pfam07686  90 CAVIPSGEGVFGKGTRLTV 108
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 17-99 4.11e-06

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 43.93  E-value: 4.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832285  17 IVSEPGKNVTLTCQPQMTWPVQAVRWEKIQPrqidllTYCN-LVHGRNFTSKFPRQIVSNCSHGRWSViVIPDVTVSDSG 95
Cdd:cd05716    7 VTGVEGGSVTIQCPYPPKYASSRKYWCKWGS------EGCQtLVSSEGVVPGGRISLTDDPDNGVFTV-TLNQLRKEDAG 79


                 ....
gi 578832285  96 LYRC 99
Cdd:cd05716   80 WYWC 83
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 13-117 7.29e-06

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 43.48  E-value: 7.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832285  13 SNSHIVSEPGKNVTLTCQPQMTWPVQAVRWEKIQPRQ-IDLLTYCNLVHGrNFTSKFPRQIVSNCSHGRWSVIVIPDVTV 91
Cdd:cd00099    4 SPRSLSVQEGESVTLSCEVSSSFSSTYIYWYRQKPGQgPEFLIYLSSSKG-KTKGGVPGRFSGSRDGTSSFSLTISNLQP 82

                         90       100
                 ....*....|....*....|....*....
gi 578832285  92 SDSGLYRCYLQASAGENE-TF--VMRLTV 117
Cdd:cd00099   83 EDSGTYYCAVSESGGTDKlTFgsGTRLTV 111
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 15-117 1.23e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.11  E-value: 1.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832285    15 SHIVSEPGKNVTLTCQ------PQMTWpvqavRWEKIQPrqidlltycnLVHGRNFTSKfprqivsncSHGRWSVIVIPD 88
Cdd:smart00410   2 PSVTVKEGESVTLSCEasgsppPEVTW-----YKQGGKL----------LAESGRFSVS---------RSGSTSTLTISN 57

                           90       100
                   ....*....|....*....|....*....
gi 578832285    89 VTVSDSGLYRCYLQASAGENETFVmRLTV 117
Cdd:smart00410  58 VTPEDSGTYTCAATNSSGSASSGT-TLTV 85
IgV_1_Nectin-3_like cd05887
First immunoglobulin variable (IgV) domain of nectin-3 (also known as poliovirus receptor ...
 16-99 2.98e-05

First immunoglobulin variable (IgV) domain of nectin-3 (also known as poliovirus receptor related protein 3), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of nectin-3 (also known as poliovirus receptor related protein 3 (PVRL3) or cluster of differentiation (CD) 113). Nectin-3 belongs to the nectin family comprised of four transmembrane glycoproteins (nectins-1 through -4). Nectins are synaptic cell adhesion molecules (CAMs) which participate in adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. For example, during spermatid development, the nectin-3,-2 trans-interaction is required for the formation of Sertoli cell-spermatid junctions in testis, and during morphogenesis of the ciliary body, the nectin-3,-1 trans-interaction is important for apex-apex adhesion between the pigment and non-pigment layers of the ciliary epithelia. Nectins also heterophilically trans-interact with other CAMs such as nectin-like molecules (Necls); nectin-3 for example, trans-interacts with Necl-5, regulating cell movement and proliferation. Other proteins with which nectin-3 interacts include the actin filament-binding protein, afadin, integrin alpha-beta3, Par-3, and PDGF receptor; its interaction with PDGF receptor regulates the latter's signaling for anti-apoptosis.


Pssm-ID: 409470  Cd Length: 110  Bit Score: 41.85  E-value: 2.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832285  16 HIVSEPGKNVTLTCQPQMTWPVQAVRWEKIQPRQIDLLTYCNLVHGRNFTSKFPRQIVSNCSHGRWSVIVIPDVTVSDSG 95
Cdd:cd05887    8 HVTAVWGKNVSLKCLIEVNETITQISWEKIHGKSSQTVAVHHPQYGISIQGEYQGRVSFKNYSLNDATITLHNVGFSDSG 87


                 ....
gi 578832285  96 LYRC 99
Cdd:cd05887   88 KYIC 91
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 22-117 6.59e-05

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 40.90  E-value: 6.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832285   22 GKNVTLTCQ--PQMTWPVQAVRWEKiQPRQIDLLTYCNLVHGRNFTSKFPRQIVSNCSHGRWSV-IVIPDVTVSDSGLYR 98
Cdd:pfam07686  11 GGSVTLPCTysSSMSEASTSVYWYR-QPPGKGPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGsLTIQNLTLSDSGTYT 89

                          90
                  ....*....|....*....
gi 578832285   99 CYLQASAGENETFVMRLTV 117
Cdd:pfam07686  90 CAVIPSGEGVFGKGTRLTV 108
IgV_HHLA2 cd16091
Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are ...
 60-112 5.68e-04

Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are composed of the immunoglobulin variable (IgV) region in HERV-H LTR-associating 2 (HHLA2; also known as B7-H7/B7 homolog 7). HHLA2 is a member of the B7 family of immune regulatory proteins. Mature human HHLA2 consists of an extracellular domain (ECD) with three immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic domain. HHLA2 is widely expressed in human cancers including non-small cell lung carcinoma (NSCLS), triple negative breast cancer (TNBC), and melanoma, but has limited expression on normal tissues. Interestingly, unlike other members of B7 family, HHLA2 is not expressed in mice or rats. HHLA2 functions as a T cell coinhibitory molecules as it inhibits the proliferation of activated CD4(+) and CD8(+) T cells and their cytokine production. Furthermore, HHLA2 is constitutively expressed on the surface of human monocytes and is induced on B cells after stimulation, however it is not inducible on T cells.


Pssm-ID: 409512  Cd Length: 107  Bit Score: 38.14  E-value: 5.68e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 578832285  60 HGRNFTSKFPRQIvsncSHGRWSVIVIpDVTVSDSGLYRCYLQASAGENETFV 112
Cdd:cd16091   56 RYRNRTSLFKDQI----SNGNASLLLR-RVQLQDEGRYKCYTSTIIGNQESFV 103
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 11-99 6.11e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 37.55  E-value: 6.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832285   11 VPSNSHIVSEpGKNVTLTCQPQMTwPVQAVRWEKIQPRQIDLLTYCNLVHGRNftskfprqivsncshgrwSVIVIPDVT 90
Cdd:pfam13927   6 VSPSSVTVRE-GETVTLTCEATGS-PPPTITWYKNGEPISSGSTRSRSLSGSN------------------STLTISNVT 65


                  ....*....
gi 578832285   91 VSDSGLYRC 99
Cdd:pfam13927  66 RSDAGTYTC 74
IgV_MOG_like cd05713
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here ...
 16-118 9.11e-04

Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here are composed of the immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG). MOG, a minor component of the myelin sheath, is an important CNS-specific autoantigen, linked to the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). It is a transmembrane protein having an extracellular Ig domain. MOG is expressed in the CNS on the outermost lamellae of the myelin sheath, and on the surface of oligodendrocytes, and may participate in the completion, compaction, and/or maintenance of myelin. This group also includes butyrophilin (BTN). BTN is the most abundant protein in bovine milk-fat globule membrane (MFGM).


Pssm-ID: 409378  Cd Length: 114  Bit Score: 37.56  E-value: 9.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832285  16 HIVSEPGKNVTLTCQ--PQMTWPVQAVRWEKIQPRQIdlltycnlVH-GRNFTSKFPRQIVS----------NCSHGRWS 82
Cdd:cd05713    9 PILALVGEDAELPCHlsPKMSAEHMEVRWFRSQFSPV--------VHlYRDGQDQEEEQMPEyrgrtellkdAIAEGSVA 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 578832285  83 VIvIPDVTVSDSGLYRCYLQASAGENETfVMRLTVA 118
Cdd:cd05713   81 LR-IHNVRPSDEGQYTCFFRSGSFYEEA-TLELKVA 114
IgV_B7-H4 cd20984
Immunoglobulin Variable (IgV) domain of B7-H4; The members here are composed of the ...
 13-109 2.30e-03

Immunoglobulin Variable (IgV) domain of B7-H4; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H4 (also known as B7-S1, B7x, or Vtcn1). B7-H4 is one of the B7 family of immune-regulatory ligands that act as negative regulators of T cell function; it contains one IgV domain and one IgC domain. The B7-family consists of structurally related cell-surface protein ligands, which bind to receptors on lymphocytes that regulate immune responses. The binding of B7-H4 to unidentified receptors results in the inhibition of TCR-mediated T cell proliferation, cell-cycle progression and IL-2 production. As a co-inhibitory molecule, B7-H4 is widely expressed in tumor tissues and its expression is significantly associated with poor prognosis in human cancers such as glioma, pancreatic cancer, oral squamous cell carcinoma, renal cell carcinoma, and lung cancer.


Pssm-ID: 409576  Cd Length: 110  Bit Score: 36.42  E-value: 2.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832285  13 SNSHIVSEPGKNVTLTC--QPQMTWPVQAVRWEKIQPRQI--------DLLTYCN-LVHGRnfTSKFPRQ-IVSNCShgr 80
Cdd:cd20984    3 TAKHLAGNIGEDGILSCtfTPDIKLSDIVIQWLKEGDSGLvhefkegkDELSRQSpMFRGR--TSLFADQvHVGNAS--- 77

                         90       100
                 ....*....|....*....|....*....
gi 578832285  81 wsvIVIPDVTVSDSGLYRCYLQASAGENE 109
Cdd:cd20984   78 ---LRLKNVQLTDAGTYLCIISNSKGTGN 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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