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Conserved domains on  [gi|578832997|ref|XP_006722714|]
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zinc finger protein 563 isoform X3 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-40 2.68e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 77.90  E-value: 2.68e-18
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 578832997    4 VAFEDVAVNFTQEEWALLGPSQKNLYRYVMQETIRNL 40
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNL 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
138-416 6.33e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 6.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832997 138 NRPYKCKLCGKAFFWPSLLRMHERTHTGEKPYEC--KQCSKAFPFYSSYRRHERMHTGEKPYEC-KQCSKALPDSSSYIR 214
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832997 215 HERTHTGEKPYTCKQCGKAFSVSSSLRRHETTHSAEKPYECKQC----------------------GKTFHHLGSFQIHM 272
Cdd:COG5048  111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSSNLSLLISS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832997 273 KRHTGDRPHKCKICGKGFDRPSLVRYHERIHTGEKPYECKQCGKTLSHSSSFRRHMIMHTGGGPHKCKICGKAFVYPSVC 352
Cdd:COG5048  191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578832997 353 QRHEKSHSGE-------KPYECKQCGKALSHSSSFRRHM--VMHTGDG--PNKCKV--CGKAFVYPSVCQRHEKTHW 416
Cdd:COG5048  271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGESlkPFSCPYslCGKLFSRNDALKRHILLHT 347
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-40 2.68e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 77.90  E-value: 2.68e-18
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 578832997    4 VAFEDVAVNFTQEEWALLGPSQKNLYRYVMQETIRNL 40
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNL 38
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-40 3.30e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.51  E-value: 3.30e-17
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 578832997   4 VAFEDVAVNFTQEEWALLGPSQKNLYRYVMQETIRNL 40
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
KRAB smart00349
krueppel associated box;
4-40 3.61e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 75.32  E-value: 3.61e-17
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 578832997     4 VAFEDVAVNFTQEEWALLGPSQKNLYRYVMQETIRNL 40
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
138-416 6.33e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 6.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832997 138 NRPYKCKLCGKAFFWPSLLRMHERTHTGEKPYEC--KQCSKAFPFYSSYRRHERMHTGEKPYEC-KQCSKALPDSSSYIR 214
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832997 215 HERTHTGEKPYTCKQCGKAFSVSSSLRRHETTHSAEKPYECKQC----------------------GKTFHHLGSFQIHM 272
Cdd:COG5048  111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSSNLSLLISS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832997 273 KRHTGDRPHKCKICGKGFDRPSLVRYHERIHTGEKPYECKQCGKTLSHSSSFRRHMIMHTGGGPHKCKICGKAFVYPSVC 352
Cdd:COG5048  191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578832997 353 QRHEKSHSGE-------KPYECKQCGKALSHSSSFRRHM--VMHTGDG--PNKCKV--CGKAFVYPSVCQRHEKTHW 416
Cdd:COG5048  271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGESlkPFSCPYslCGKLFSRNDALKRHILLHT 347
zf-H2C2_2 pfam13465
Zinc-finger double domain;
156-178 1.00e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.00e-03
                          10        20
                  ....*....|....*....|...
gi 578832997  156 LRMHERTHTGEKPYECKQCSKAF 178
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-40 2.68e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 77.90  E-value: 2.68e-18
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 578832997    4 VAFEDVAVNFTQEEWALLGPSQKNLYRYVMQETIRNL 40
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNL 38
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-40 3.30e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.51  E-value: 3.30e-17
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 578832997   4 VAFEDVAVNFTQEEWALLGPSQKNLYRYVMQETIRNL 40
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
KRAB smart00349
krueppel associated box;
4-40 3.61e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 75.32  E-value: 3.61e-17
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 578832997     4 VAFEDVAVNFTQEEWALLGPSQKNLYRYVMQETIRNL 40
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
138-416 6.33e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 6.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832997 138 NRPYKCKLCGKAFFWPSLLRMHERTHTGEKPYEC--KQCSKAFPFYSSYRRHERMHTGEKPYEC-KQCSKALPDSSSYIR 214
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832997 215 HERTHTGEKPYTCKQCGKAFSVSSSLRRHETTHSAEKPYECKQC----------------------GKTFHHLGSFQIHM 272
Cdd:COG5048  111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSSNLSLLISS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832997 273 KRHTGDRPHKCKICGKGFDRPSLVRYHERIHTGEKPYECKQCGKTLSHSSSFRRHMIMHTGGGPHKCKICGKAFVYPSVC 352
Cdd:COG5048  191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578832997 353 QRHEKSHSGE-------KPYECKQCGKALSHSSSFRRHM--VMHTGDG--PNKCKV--CGKAFVYPSVCQRHEKTHW 416
Cdd:COG5048  271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGESlkPFSCPYslCGKLFSRNDALKRHILLHT 347
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
181-356 1.26e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 1.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832997 181 YSSYRRHERMHTG-EKPYECKQCSKALPDSSSYIRHERT--HTGE--KPYTC--KQCGKAFSVSSSLRRHETTHSAEKPY 253
Cdd:COG5048  273 SSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPA 352

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832997 254 ECK--QCGKTFHHLG-----SFQIHMKRHTGDRPHKC--KICGKGFDRPSLVRYHERIHTGEKPYECK--QCGKTLSHSS 322
Cdd:COG5048  353 KEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHY 432

                        170       180       190
                 ....*....|....*....|....*....|....
gi 578832997 323 SFRRHMIMHTGGGPHKCKICGKAFVYPSVCQRHE 356
Cdd:COG5048  433 NLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
120-300 5.58e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 5.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832997 120 KTFSSRRNLRRHMVVQGGNR-PYKCKLCGKAFFWPSLLRMHERT--HTGE--KPYEC--KQCSKAFPFYSSYRRHERMHT 192
Cdd:COG5048  268 ASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT 347

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832997 193 GEKPYECK--QCSKAL-----PDSSSYIRHERTHTGEKPYTC--KQCGKAFSVSSSLRRHETTHSAEKPYECK--QCGKT 261
Cdd:COG5048  348 SISPAKEKllNSSSKFspllnNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKS 427

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 578832997 262 FHHLGSFQIHMKRHTGDRPHKCKICGKGFDRPSLVRYHE 300
Cdd:COG5048  428 FNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
70-262 6.37e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 6.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832997  70 SGHKPHEYQEYGEKPHTHKQRGKAFSYHHSFQSRGRPHTgkkRYECKECGKTFSSRRNLRRHM----VVQGGNRPYKC-- 143
Cdd:COG5048  250 SSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsvnHSGESLKPFSCpy 326

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832997 144 KLCGKAFFWPSLLRMHERTHTGEKPYECK--QCSKAFPFYSSYRRHERMH-----TGEKPYEC--KQCSKALPDSSSYIR 214
Cdd:COG5048  327 SLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSL 406

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 578832997 215 HERTHTGEKPYTCK--QCGKAFSVSSSLRRHETTHSAEKPYECKQCGKTF 262
Cdd:COG5048  407 HIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
145-388 1.61e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 1.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832997 145 LCGKAFFWPSLLRMHERTHTGEKPYECKQCSKAFPFYSSYRRHERMH--TGEKPYECKQCSKALPDSSSY----IRHERT 218
Cdd:COG5048  176 LSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENssSSLPLTTNSQLSPKSLLSQSPsslsSSDSSS 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832997 219 HTGEKPYTCKQcGKAFSVSSSLRRHETTHSA-EKPYECKQCGKTFHHLGSFQIHM--KRHTG--DRPHKCKI--CGKGFD 291
Cdd:COG5048  256 SASESPRSSLP-TASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGesLKPFSCPYslCGKLFS 334

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832997 292 RPSLVRYHERIHTGEKPYECK--QCGKTLSHSSSFRRHMIMHTGGGPHKCKI-------CGKAFVYPSVCQRHEKSHSGE 362
Cdd:COG5048  335 RNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKDLKNDKKsetlsnsCIRNFKRDSNLSLHIITHLSF 414

                        250       260
                 ....*....|....*....|....*...
gi 578832997 363 KPYECK--QCGKALSHSSSFRRHMVMHT 388
Cdd:COG5048  415 RPYNCKnpPCSKSFNRHYNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
156-178 1.00e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.00e-03
                          10        20
                  ....*....|....*....|...
gi 578832997  156 LRMHERTHTGEKPYECKQCSKAF 178
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
179-415 1.84e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 1.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832997 179 PFYSSYRRHERMHTGEK-PYECKQCSKALPDSSSYIRHERTH-TGEKPYTCKQCGKAFSVSSSLRRHE----TTHSAEKP 252
Cdd:COG5048  181 SSNLSLLISSNVSTSIPsSSENSPLSSSYSIPSSSSDQNLENsSSSLPLTTNSQLSPKSLLSQSPSSLsssdSSSSASES 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832997 253 YECKQCGKTFHHLGSFQIHMKRHTG-DRPHKCKICGKGFDRPSLVRYHER--IHTGE--KPYEC--KQCGKTLSHSSSFR 325
Cdd:COG5048  261 PRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALK 340

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832997 326 RHMIMHTGGGPHKCKIC-------GKAFVYPSVCQRHEKSHSGEKPYEC--KQCGKALSHSSSFRRHMVMHTGDGP--NK 394
Cdd:COG5048  341 RHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCK 420

                        250       260
                 ....*....|....*....|.
gi 578832997 395 CKVCGKAFVYPSVCQRHEKTH 415
Cdd:COG5048  421 NPPCSKSFNRHYNLIPHKKIH 441
zf-H2C2_2 pfam13465
Zinc-finger double domain;
214-235 2.55e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.55e-03
                          10        20
                  ....*....|....*....|..
gi 578832997  214 RHERTHTGEKPYTCKQCGKAFS 235
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
323-348 7.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 7.09e-03
                          10        20
                  ....*....|....*....|....*.
gi 578832997  323 SFRRHMIMHTGGGPHKCKICGKAFVY 348
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
183-205 7.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 7.09e-03
                          10        20
                  ....*....|....*....|...
gi 578832997  183 SYRRHERMHTGEKPYECKQCSKA 205
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKS 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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