NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|578834584|ref|XP_006723318|]
View 

G patch domain-containing protein 1 isoform X1 [Homo sapiens]

Protein Classification

G patch domain-containing protein 1( domain architecture ID 10543151)

G patch domain-containing protein 1 (GPTC1)

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DUF1604 pfam07713
Protein of unknown function (DUF1604); This family is found at the N-terminus of several ...
 31-116 1.23e-47

Protein of unknown function (DUF1604); This family is found at the N-terminus of several eukaryotic RNA processing proteins.


:

Pssm-ID: 462241  Cd Length: 84  Bit Score: 161.53  E-value: 1.23e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578834584   31 PIPLQDQTVRDEKGRyKRFHGAFSGGFSAGYFNTVGSKEGWTPSTFVSSRQNRADKSVLGPEDFMDEEDLSEFGiAPKAI 110
Cdd:pfam07713   1 YVPVWKQEVRDEQGR-RRFHGAFTGGFSAGYFNTVGSKEGWTPSTFKSSRSNRAKKKQQRPEDFMDEEDLGEFG-APRQL 78


                  ....*.
gi 578834584  111 VTTDDF 116
Cdd:pfam07713  79 RTTDEF 84
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 154-181 3.39e-05

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


:

Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 41.34  E-value: 3.39e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 578834584  154 SVGFELLRKMGWKEGQGVGP---------RVKRRPRR 181
Cdd:pfam01585   3 NIGFKLLQKMGWKEGQGLGKneqgiaepiEAKIKKDR 39
DAGK_cat super family cl01255
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts ...
 403-486 7.86e-04

Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologs. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.


The actual alignment was detected with superfamily member PLN02935:

Pssm-ID: 445337 [Multi-domain]  Cd Length: 508  Bit Score: 42.51  E-value: 7.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578834584 403 PDPGTHSKHQLNASKRA--ELLGETPIQGSATSVLEFLS-----QKDKERIKEMKQATDLKAAQLKAR---SLAQNAQSS 472
Cdd:PLN02935   3 PDNGFSDSLSLFHSEKAvqELLQQTPIQDTDDHLVEFSEalrtvAKALRRVAEGKALAQAEAAEWKRKyelERARNQQLE 82

                         90
                 ....*....|....
gi 578834584 473 RAQLSPAAAAGHCS 486
Cdd:PLN02935  83 HKELSSGECNEESN 96
 
Name Accession Description Interval E-value
DUF1604 pfam07713
Protein of unknown function (DUF1604); This family is found at the N-terminus of several ...
 31-116 1.23e-47

Protein of unknown function (DUF1604); This family is found at the N-terminus of several eukaryotic RNA processing proteins.


Pssm-ID: 462241  Cd Length: 84  Bit Score: 161.53  E-value: 1.23e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578834584   31 PIPLQDQTVRDEKGRyKRFHGAFSGGFSAGYFNTVGSKEGWTPSTFVSSRQNRADKSVLGPEDFMDEEDLSEFGiAPKAI 110
Cdd:pfam07713   1 YVPVWKQEVRDEQGR-RRFHGAFTGGFSAGYFNTVGSKEGWTPSTFKSSRSNRAKKKQQRPEDFMDEEDLGEFG-APRQL 78


                  ....*.
gi 578834584  111 VTTDDF 116
Cdd:pfam07713  79 RTTDEF 84
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 154-181 3.39e-05

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 41.34  E-value: 3.39e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 578834584  154 SVGFELLRKMGWKEGQGVGP---------RVKRRPRR 181
Cdd:pfam01585   3 NIGFKLLQKMGWKEGQGLGKneqgiaepiEAKIKKDR 39
G_patch smart00443
glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in ...
 154-172 4.98e-04

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.


Pssm-ID: 197727 [Multi-domain]  Cd Length: 47  Bit Score: 38.29  E-value: 4.98e-04
                           10
                   ....*....|....*....
gi 578834584   154 SVGFELLRKMGWKEGQGVG 172
Cdd:smart00443   5 NIGAKLLRKMGWKEGQGLG 23
PLN02935 PLN02935
Bifunctional NADH kinase/NAD(+) kinase
 403-486 7.86e-04

Bifunctional NADH kinase/NAD(+) kinase


Pssm-ID: 215505 [Multi-domain]  Cd Length: 508  Bit Score: 42.51  E-value: 7.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578834584 403 PDPGTHSKHQLNASKRA--ELLGETPIQGSATSVLEFLS-----QKDKERIKEMKQATDLKAAQLKAR---SLAQNAQSS 472
Cdd:PLN02935   3 PDNGFSDSLSLFHSEKAvqELLQQTPIQDTDDHLVEFSEalrtvAKALRRVAEGKALAQAEAAEWKRKyelERARNQQLE 82

                         90
                 ....*....|....
gi 578834584 473 RAQLSPAAAAGHCS 486
Cdd:PLN02935  83 HKELSSGECNEESN 96
 
Name Accession Description Interval E-value
DUF1604 pfam07713
Protein of unknown function (DUF1604); This family is found at the N-terminus of several ...
 31-116 1.23e-47

Protein of unknown function (DUF1604); This family is found at the N-terminus of several eukaryotic RNA processing proteins.


Pssm-ID: 462241  Cd Length: 84  Bit Score: 161.53  E-value: 1.23e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578834584   31 PIPLQDQTVRDEKGRyKRFHGAFSGGFSAGYFNTVGSKEGWTPSTFVSSRQNRADKSVLGPEDFMDEEDLSEFGiAPKAI 110
Cdd:pfam07713   1 YVPVWKQEVRDEQGR-RRFHGAFTGGFSAGYFNTVGSKEGWTPSTFKSSRSNRAKKKQQRPEDFMDEEDLGEFG-APRQL 78


                  ....*.
gi 578834584  111 VTTDDF 116
Cdd:pfam07713  79 RTTDEF 84
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 154-181 3.39e-05

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 41.34  E-value: 3.39e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 578834584  154 SVGFELLRKMGWKEGQGVGP---------RVKRRPRR 181
Cdd:pfam01585   3 NIGFKLLQKMGWKEGQGLGKneqgiaepiEAKIKKDR 39
G_patch smart00443
glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in ...
 154-172 4.98e-04

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.


Pssm-ID: 197727 [Multi-domain]  Cd Length: 47  Bit Score: 38.29  E-value: 4.98e-04
                           10
                   ....*....|....*....
gi 578834584   154 SVGFELLRKMGWKEGQGVG 172
Cdd:smart00443   5 NIGAKLLRKMGWKEGQGLG 23
PLN02935 PLN02935
Bifunctional NADH kinase/NAD(+) kinase
 403-486 7.86e-04

Bifunctional NADH kinase/NAD(+) kinase


Pssm-ID: 215505 [Multi-domain]  Cd Length: 508  Bit Score: 42.51  E-value: 7.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578834584 403 PDPGTHSKHQLNASKRA--ELLGETPIQGSATSVLEFLS-----QKDKERIKEMKQATDLKAAQLKAR---SLAQNAQSS 472
Cdd:PLN02935   3 PDNGFSDSLSLFHSEKAvqELLQQTPIQDTDDHLVEFSEalrtvAKALRRVAEGKALAQAEAAEWKRKyelERARNQQLE 82

                         90
                 ....*....|....
gi 578834584 473 RAQLSPAAAAGHCS 486
Cdd:PLN02935  83 HKELSSGECNEESN 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH