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Conserved domains on  [gi|578836682|ref|XP_006724114|]
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nuclear encoded mitochondrial protein C21orf2 isoform X4 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 75-155 1.81e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 1.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836682  75 NSISTLEPVSRCQRLSELYLRRNRIPSLAELF-YLKGLPRLRVLWLAENPCCgtSPHRYRMTVLRTLPRLQKLDNQAVTE 153
Cdd:cd21340  130 NNIDSLEPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVC--KKPKYRDKIILASKSLEVLDGKEITD 207


                 ..
gi 578836682 154 EE 155
Cdd:cd21340  208 TE 209
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 75-155 1.81e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 1.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836682  75 NSISTLEPVSRCQRLSELYLRRNRIPSLAELF-YLKGLPRLRVLWLAENPCCgtSPHRYRMTVLRTLPRLQKLDNQAVTE 153
Cdd:cd21340  130 NNIDSLEPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVC--KKPKYRDKIILASKSLEVLDGKEITD 207


                 ..
gi 578836682 154 EE 155
Cdd:cd21340  208 TE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
75-158 1.93e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.78  E-value: 1.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836682  75 NSISTL-EPVSRCQRLSELYLRRNRIPSLAElfyLKGLPRLRVLWLAENPCCGTSPhryrmtvLRTLPRLQKLD--NQAV 151
Cdd:COG4886  215 NQLTDLpEPLANLTNLETLDLSNNQLTDLPE---LGNLTNLEELDLSNNQLTDLPP-------LANLTNLKTLDlsNNQL 284


                 ....*..
gi 578836682 152 TEEELSR 158
Cdd:COG4886  285 TDLKLKE 291
LRR_9 pfam14580
Leucine-rich repeat;
89-159 1.54e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 41.67  E-value: 1.54e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578836682   89 LSELYLRRNRIPSLAELFYLKGLPRLRVLWLAENPCCgTSPHrYRMTVLRTLPRLQKLDNQAVTEEELSRA 159
Cdd:pfam14580  90 LTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVT-NKPH-YRLYVIYKVPQLRLLDFRKVKQKERQAA 158
LRRcap smart00446
occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich ...
 129-147 9.61e-04

occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich repeats in "sds22-like" and "typical" LRR-containing proteins.


Pssm-ID: 197729  Cd Length: 19  Bit Score: 35.75  E-value: 9.61e-04
                           10
                   ....*....|....*....
gi 578836682   129 PHRYRMTVLRTLPRLQKLD 147
Cdd:smart00446   1 LAHYREKVIELLPQLRKLD 19
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 75-155 1.81e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 1.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836682  75 NSISTLEPVSRCQRLSELYLRRNRIPSLAELF-YLKGLPRLRVLWLAENPCCgtSPHRYRMTVLRTLPRLQKLDNQAVTE 153
Cdd:cd21340  130 NNIDSLEPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVC--KKPKYRDKIILASKSLEVLDGKEITD 207


                 ..
gi 578836682 154 EE 155
Cdd:cd21340  208 TE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
75-158 1.93e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.78  E-value: 1.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836682  75 NSISTL-EPVSRCQRLSELYLRRNRIPSLAElfyLKGLPRLRVLWLAENPCCGTSPhryrmtvLRTLPRLQKLD--NQAV 151
Cdd:COG4886  215 NQLTDLpEPLANLTNLETLDLSNNQLTDLPE---LGNLTNLEELDLSNNQLTDLPP-------LANLTNLKTLDlsNNQL 284


                 ....*..
gi 578836682 152 TEEELSR 158
Cdd:COG4886  285 TDLKLKE 291
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
75-147 1.85e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 45.69  E-value: 1.85e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578836682  75 NSISTL-EPVSRCQRLSELYLRRNRIPSLAELfyLKGLPRLRVLWLAENpccgtsphryRMT----VLRTLPRLQKLD 147
Cdd:COG4886  146 NQLTDLpEPLGNLTNLKSLDLSNNQLTDLPEE--LGNLTNLKELDLSNN----------QITdlpePLGNLTNLEELD 211
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
75-158 1.90e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 45.69  E-value: 1.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836682  75 NSISTL-EPVSRCQRLSELYLRRNRIPSLAElfYLKGLPRLRVLWLAENpccgtsphryRMT----VLRTLPRLQKLD-- 147
Cdd:COG4886  169 NQLTDLpEELGNLTNLKELDLSNNQITDLPE--PLGNLTNLEELDLSGN----------QLTdlpePLANLTNLETLDls 236

                         90
                 ....*....|..
gi 578836682 148 -NQAVTEEELSR 158
Cdd:COG4886  237 nNQLTDLPELGN 248
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 75-155 7.98e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.85  E-value: 7.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836682  75 NSISTLEPVSRCQRLSELYLRRNRIPSLAelfYLKGLPRLRVLWLAENpccgtsphryRMTV---LRTLPRLQ--KLDNQ 149
Cdd:cd21340   34 NKITKIENLEFLTNLTHLYLQNNQIEKIE---NLENLVNLKKLYLGGN----------RISVvegLENLTNLEelHIENQ 100


                 ....*.
gi 578836682 150 AVTEEE 155
Cdd:cd21340  101 RLPPGE 106
LRR_9 pfam14580
Leucine-rich repeat;
89-159 1.54e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 41.67  E-value: 1.54e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578836682   89 LSELYLRRNRIPSLAELFYLKGLPRLRVLWLAENPCCgTSPHrYRMTVLRTLPRLQKLDNQAVTEEELSRA 159
Cdd:pfam14580  90 LTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVT-NKPH-YRLYVIYKVPQLRLLDFRKVKQKERQAA 158
LRRcap smart00446
occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich ...
 129-147 9.61e-04

occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich repeats in "sds22-like" and "typical" LRR-containing proteins.


Pssm-ID: 197729  Cd Length: 19  Bit Score: 35.75  E-value: 9.61e-04
                           10
                   ....*....|....*....
gi 578836682   129 PHRYRMTVLRTLPRLQKLD 147
Cdd:smart00446   1 LAHYREKVIELLPQLRKLD 19
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 87-123 1.03e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 1.03e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 578836682   87 QRLSELYLRRNRIPSLAELfylKGLPRLRVLWLAENP 123
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPL---AKLPNLETLDLSGNN 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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