NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|578838105|ref|XP_006724622|]
View 

divergent protein kinase domain 2B isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PIP49_C super family cl48131
Protein-kinase domain of FAM69; This is the C-terminal region of a family of FAM69 proteins ...
 164-305 8.33e-27

Protein-kinase domain of FAM69; This is the C-terminal region of a family of FAM69 proteins from Metazoa and Viridiplantae that are active protein-kinases. The family members have a short transmembrane helix close to the N-terminus, and thereafter are highly enriched with cysteines. FAM69 proteins are localized to the endoplasmic reticulum. Many members also have a short EF-hand, calcium-binding, domain just upstream of the kinase domain. The exact function of the more N-terminal family is uncertain.


The actual alignment was detected with superfamily member pfam12260:

Pssm-ID: 463512  Cd Length: 188  Bit Score: 104.68  E-value: 8.33e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838105  164 LVQIFPGAEgwPLPKYLGSCGRFLVSTSTRPLQ---------EFYDAPPDQAADLAYQLLGVLESLRSNDLNyFFYFTHI 234
Cdd:pfam12260  12 LLQIFQDRE--PFPKYLGSCGRLYVVEYVGAGPllgisrrplDWFSPPWPRRAKIALQLLELVEDLFNGDPG-FLYMCDV 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838105  235 DAG--------------------------SQEANRAGENKD--IFSCLvSGCQAQLPSCESISEKQSLVLVCQKLLPRLL 286
Cdd:pfam12260  89 SLEnfgvtndgrlklvdldnvfpedklrrKISEQKCEKDEDcdFFDCL-SFCDLEKDRCSSEVVNPNLQKVCQKLLDYLL 167

                         170
                  ....*....|....*....
gi 578838105  287 QGRfPSPVQDDIDSILVQC 305
Cdd:pfam12260 168 RGP-PSPLPEELEKLLQEC 185
 
Name Accession Description Interval E-value
PIP49_C pfam12260
Protein-kinase domain of FAM69; This is the C-terminal region of a family of FAM69 proteins ...
 164-305 8.33e-27

Protein-kinase domain of FAM69; This is the C-terminal region of a family of FAM69 proteins from Metazoa and Viridiplantae that are active protein-kinases. The family members have a short transmembrane helix close to the N-terminus, and thereafter are highly enriched with cysteines. FAM69 proteins are localized to the endoplasmic reticulum. Many members also have a short EF-hand, calcium-binding, domain just upstream of the kinase domain. The exact function of the more N-terminal family is uncertain.


Pssm-ID: 463512  Cd Length: 188  Bit Score: 104.68  E-value: 8.33e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838105  164 LVQIFPGAEgwPLPKYLGSCGRFLVSTSTRPLQ---------EFYDAPPDQAADLAYQLLGVLESLRSNDLNyFFYFTHI 234
Cdd:pfam12260  12 LLQIFQDRE--PFPKYLGSCGRLYVVEYVGAGPllgisrrplDWFSPPWPRRAKIALQLLELVEDLFNGDPG-FLYMCDV 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838105  235 DAG--------------------------SQEANRAGENKD--IFSCLvSGCQAQLPSCESISEKQSLVLVCQKLLPRLL 286
Cdd:pfam12260  89 SLEnfgvtndgrlklvdldnvfpedklrrKISEQKCEKDEDcdFFDCL-SFCDLEKDRCSSEVVNPNLQKVCQKLLDYLL 167

                         170
                  ....*....|....*....
gi 578838105  287 QGRfPSPVQDDIDSILVQC 305
Cdd:pfam12260 168 RGP-PSPLPEELEKLLQEC 185
 
Name Accession Description Interval E-value
PIP49_C pfam12260
Protein-kinase domain of FAM69; This is the C-terminal region of a family of FAM69 proteins ...
 164-305 8.33e-27

Protein-kinase domain of FAM69; This is the C-terminal region of a family of FAM69 proteins from Metazoa and Viridiplantae that are active protein-kinases. The family members have a short transmembrane helix close to the N-terminus, and thereafter are highly enriched with cysteines. FAM69 proteins are localized to the endoplasmic reticulum. Many members also have a short EF-hand, calcium-binding, domain just upstream of the kinase domain. The exact function of the more N-terminal family is uncertain.


Pssm-ID: 463512  Cd Length: 188  Bit Score: 104.68  E-value: 8.33e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838105  164 LVQIFPGAEgwPLPKYLGSCGRFLVSTSTRPLQ---------EFYDAPPDQAADLAYQLLGVLESLRSNDLNyFFYFTHI 234
Cdd:pfam12260  12 LLQIFQDRE--PFPKYLGSCGRLYVVEYVGAGPllgisrrplDWFSPPWPRRAKIALQLLELVEDLFNGDPG-FLYMCDV 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838105  235 DAG--------------------------SQEANRAGENKD--IFSCLvSGCQAQLPSCESISEKQSLVLVCQKLLPRLL 286
Cdd:pfam12260  89 SLEnfgvtndgrlklvdldnvfpedklrrKISEQKCEKDEDcdFFDCL-SFCDLEKDRCSSEVVNPNLQKVCQKLLDYLL 167

                         170
                  ....*....|....*....
gi 578838105  287 QGRfPSPVQDDIDSILVQC 305
Cdd:pfam12260 168 RGP-PSPLPEELEKLLQEC 185
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH