second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641802973  245 CYYDVVLSFSSNSELVESFSGSPNCLDEELRAHKAIISSRSPFFRHLLQRRIQTGEeitDRTLRTPTRIILDESIIPKKY 324
Cdd:cd18284     1 DYGDAVLVFASDKETVESSSGKVNEPDFELRCHKAILSARSPFFRNLLQRRIRTGE---DRTLSTPTRIVLDESIIPRRY 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 641802973  325 AKVILNCMYTDVVDLS-VLHCSPSVGSLSEVQALVAGKLNMTRAEEAMELYHIALFLEFNMLAQGCEDI 392
Cdd:cd18284    78 ARVLLHAMYTDSVDLSlILRSSPSESSLSEVQAIVAGKGPETRLEEAMELYHIARFLEFDILAQGCEDI 146

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641802973  140 YCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDINTAGIDMPMFSALLHYLYTGEFGMEDSRFQNVDI 219
Cdd:cd18283     1 YCTDVDLVFQGTCFPVHRAILSARCPFFRDLLSSSPGYGAEIPVDLPTAGIDVPMFSALLRYLYTGEFGSEDSRSQNLDV 80

                          90
                  ....*....|..
gi 641802973  220 LVQLSEEFGTPN 231
Cdd:cd18283    81 LIQLSEEFGTPN 92

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641802973  245 CYYDVVLSFSSNSELVESFSGSPNCLDEELRAHKAIISSRSPFFRHLLQRRIQTGEeitDRTLRTPTRIILDESIIPKKY 324
Cdd:cd18284     1 DYGDAVLVFASDKETVESSSGKVNEPDFELRCHKAILSARSPFFRNLLQRRIRTGE---DRTLSTPTRIVLDESIIPRRY 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 641802973  325 AKVILNCMYTDVVDLS-VLHCSPSVGSLSEVQALVAGKLNMTRAEEAMELYHIALFLEFNMLAQGCEDI 392
Cdd:cd18284    78 ARVLLHAMYTDSVDLSlILRSSPSESSLSEVQAIVAGKGPETRLEEAMELYHIARFLEFDILAQGCEDI 146

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641802973  140 YCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDINTAGIDMPMFSALLHYLYTGEFGMEDSRFQNVDI 219
Cdd:cd18283     1 YCTDVDLVFQGTCFPVHRAILSARCPFFRDLLSSSPGYGAEIPVDLPTAGIDVPMFSALLRYLYTGEFGSEDSRSQNLDV 80

                          90
                  ....*....|..
gi 641802973  220 LVQLSEEFGTPN 231
Cdd:cd18283    81 LIQLSEEFGTPN 92

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641802973    143 DVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYG--AEIIMDintaGIDMPMFSALLHYLYTGEFGMEDsrfQNVDIL 220
Cdd:smart00225    1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESdkSEIYLD----DVSPEDFRALLNFLYTGKLDLPE---ENVEEL 73

                            90
                    ....*....|
gi 641802973    221 VQLSEEFGTP 230
Cdd:smart00225   74 LELADYLQIP 83

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 641802973   413 YGSKWVHRQALHFLCEEFTQVMTSDVFYELSKDHLLTAIQSDYLQ-ASEQDILKYLVKWGEHQLMKR 478
Cdd:pfam07707   11 YGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNvPSEEEVFEAVIRWVKHDVERR 77

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641802973   269 CLDEELRAHKAIISSRSPFFRHLLQrriQTGEEITDrtlrtpTRIILDEsiIPKKYAKVILNCMYTDVVDlsvlhcspsv 348
Cdd:pfam00651   17 VGDKEFRAHKAVLAACSPYFKALFS---GQESESSV------SEITLDD--VSPEDFEALLEFMYTGKLI---------- 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 641802973   349 gslsevqalvagklnmtRAEEAMELYHIALFLEFNMLAQGCEDIIAESI 397
Cdd:pfam00651   76 -----------------SEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641802973  245 CYYDVVLSFSSNSELVESFSGSPNCLDEELRAHKAIISSRSPFFRHLLQRRIQTGEeitDRTLRTPTRIILDESIIPKKY 324
Cdd:cd18284     1 DYGDAVLVFASDKETVESSSGKVNEPDFELRCHKAILSARSPFFRNLLQRRIRTGE---DRTLSTPTRIVLDESIIPRRY 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 641802973  325 AKVILNCMYTDVVDLS-VLHCSPSVGSLSEVQALVAGKLNMTRAEEAMELYHIALFLEFNMLAQGCEDI 392
Cdd:cd18284    78 ARVLLHAMYTDSVDLSlILRSSPSESSLSEVQAIVAGKGPETRLEEAMELYHIARFLEFDILAQGCEDI 146

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641802973  140 YCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDINTAGIDMPMFSALLHYLYTGEFGMEDSRFQNVDI 219
Cdd:cd18283     1 YCTDVDLVFQGTCFPVHRAILSARCPFFRDLLSSSPGYGAEIPVDLPTAGIDVPMFSALLRYLYTGEFGSEDSRSQNLDV 80

                          90
                  ....*....|..
gi 641802973  220 LVQLSEEFGTPN 231
Cdd:cd18283    81 LIQLSEEFGTPN 92

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641802973   137 EYKYCtDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPE--YGAEIIMDintaGIDMPMFSALLHYLYTGEFGMEDsrf 214
Cdd:pfam00651    7 QGELC-DVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESesSVSEITLD----DVSPEDFEALLEFMYTGKLISEE--- 78

                           90       100
                   ....*....|....*....|.
gi 641802973   215 qNVDILVQLSEEFGTPNPLDV 235
Cdd:pfam00651   79 -NVDDLLAAADKLQIPSLVDK 98

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641802973  130 KDMADLYEYKYCTDVDLIFQE-TCFPVHRAILAARCPFFKTLLSsspeYGAEIIMDintAGIDMPMFSALLHYLYTGEFG 208
Cdd:cd18299     1 EDLRNLLHSPSCADVVFILQGgVRIFAHRIVLAAASSVFADLFL----MMTVVTLD---SDITPEAFRRVLEFLYTGVLD 73

                          90
                  ....*....|....*..
gi 641802973  209 MEDSRFQNVDILVQLSE 225
Cdd:cd18299    74 ENEDDLKELKDAAELLE 90

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 641802973    413 YGSKWVHRQALHFLCEEFTQVMTSDVFYELSKDHLLTAIQSDYLQ-ASEQDILKYLVKWGEHQLMKRIaDREPNLLS 488
Cdd:smart00875   11 HGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNvSSEEEVFEAVLRWVKHDPEKRR-EHLPELLE 86

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641802973  136 YEYKYCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEiiMDINTAGIDMPMFSALLHYLYTGEFGMEDsrfQ 215
Cdd:cd18314     1 YNDSEFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNL--KEVTLEDVEPEIFETVLKYMYTGQVTLSE---E 75

                          90
                  ....*....|....*
gi 641802973  216 NVDILVQLSEEFGTP 230
Cdd:cd18314    76 NVLDLLMLASKYQVP 90

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641802973  128 LQKDMADLYEYKYCTDVDLIFQETCFPVHRAILAARCPFFKTLLS-SSPEYGAEII-MDINTAGidmpMFSALLHYLYTG 205
Cdd:cd18286     4 LGKDLLQLFLNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSgSWAESNSSEItLTGVSHA----AVSFVLLFIYGG 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 641802973  206 EfgMEDSRFQNVDILVQLSEEFGTPNPLDV 235
Cdd:cd18286    80 V--LDLPDDVNLGELLSLADMYGLDGLKDV 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 641802973  271 DEELRAHKAIISSRSPFFRHLLqrriqTGEEITDRTlrtpTRIILDEsiIPKKYAKVILNCMYTDVVDLSV 341
Cdd:cd18186    10 GREFPAHRAVLAARSPYFRAMF-----SSGMKESSS----SEIELDD--VSPEAFEALLDYIYTGELELSE 69

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641802973  128 LQKDMADLYEYKYCTDVDLIFQETCFPVHRAILAARCPFFKTLLSS--SPEYGAEIIMDintaGIDMPMFSALLHYLYTG 205
Cdd:cd18269    14 LQDGLKDLLDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSdlEESKKKEVVLE----DVDPDVMGMILKYLYTS 89

                          90       100
                  ....*....|....*....|....*
gi 641802973  206 EFGMEDsrfQNVDILVQLSEEFGTP 230
Cdd:cd18269    90 EIDLND---QNVQDIFALASRFQIP 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641802973  140 YCtDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDINTAGIDMPMFSALLHYLYTGEFGMEDSRFQNV-- 217
Cdd:cd18245    14 LC-DATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGSTYKIELEGISVEVMEEILDYIYTGQIKLSEDNIQDIvq 92

                  ....*
gi 641802973  218 --DIL 220
Cdd:cd18245    93 aaDLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 641802973  141 CTDVDLIFQE-TCFPVHRAILAARCPFFKTLLSSSPEYGA---------EIIMDintAGIDMPMFSALLHYLYTGEFG 208
Cdd:cd18310    18 YSDAEIIVEGgRPVPVHRCILAARSPFFRDIFASAKAEGAntkpklelrELIPG---GIVGYDAFMLVLSYLYSGRLR 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641802973  128 LQKDMADLYEYKYCTDVDLIFQETCFPVHRAILAARCPFFKTLLSS--SPEYGAEIIMDintaGIDMPMFSALLHYLYTG 205
Cdd:cd18341    14 LQDGLKELLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSeeSEEKKKEVVLD----NVDPNIMDMILKYLYSA 89

                          90
                  ....*....|..
gi 641802973  206 EFGMEDSRFQNV 217
Cdd:cd18341    90 EIDLNDGNVQDI 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641802973  120 LARPEARtLQKDMADLYEYKYCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDINTagIDMPMFSALL 199
Cdd:cd18343     1 LKVPECR-LAEDLGNLWENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEIND--VDPEVFKEMM 77

                  ....*.
gi 641802973  200 HYLYTG 205
Cdd:cd18343    78 RFIYTG 83

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 641802973  142 TDVDLIFQETCFPVHRAILAARCPFFKTLLSS-SPEYGAEIIMDINTAGIdmpmFSALLHYLYTGE 206
Cdd:cd18315     2 VDVTLACEGGSLKAHKLVLAAASPYFAALLKEtPPDEHPVIILPDVPYSE----LKALLDFIYTGE 63

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641802973  125 ARTLQKDMADLYEYKYCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGA---EIIMDINTAGIDmpMFSALLHY 201
Cdd:cd18292     1 SREFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWWSESkqsEIELVEDPECAA--VFEKFLRY 78

                  ....*
gi 641802973  202 LYTGE 206
Cdd:cd18292    79 LYTGQ 83

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 641802973  403 IAILKWSSQpYGSKWVHRQALHFLCEEFTQVMTSDVFYELSKDHLLTAIQSDYLQA-SEQDILKYLVKWGEHQLMKR 478
Cdd:cd18455     6 IGIRDFAER-FSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVgNEEYIFEAVLRWVRHDPEER 81

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641802973    268 NCLDEELRAHKAIISSRSPFFRHLLQRRIQTGEEitdrtlrtpTRIILDEsiIPKKYAKVILNCMYTdvvdlsvlhcsps 347
Cdd:smart00225    5 VVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDK---------SEIYLDD--VSPEDFRALLNFLYT------------- 60

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|
gi 641802973    348 vgslsevqalvaGKLNMTRaEEAMELYHIALFLEFNMLAQGCEDIIAESI 397
Cdd:smart00225   61 ------------GKLDLPE-ENVEELLELADYLQIPGLVELCEEFLLKLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641802973  123 PEARtLQKDMADLYEYKYCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDINTagIDMPMFSALLHYL 202
Cdd:cd18345     1 PECR-LSDDLGLLFERSAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITD--VDHEVMREMLRFI 77

                  ....
gi 641802973  203 YTGE 206
Cdd:cd18345    78 YTGK 81

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641802973  143 DVDLIFQETCFPVHRAILAARCPFFKTLLSSS--PEYGAEIIMdintAGIDMPMFSALLHYLYTGEFGmEDSRFQNVDIL 220
Cdd:cd18300    11 DVTFIVEDGTIPAHKALLVARCDVMAAMFGGNfrESSAKEVEL----PGVSKETFLALLEYLYTDQAP-ILEDGDCVGLI 85

                          90
                  ....*....|.
gi 641802973  221 VqLSEEFGTPN 231
Cdd:cd18300    86 V-LANRLCLPR 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641802973  139 KYCtDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPeygAEIIMD-INTAGIDMPMFSALLHYLYTGEFGMEDSRFQNV 217
Cdd:cd18247    18 KLC-DVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDM---VESKQDeITMQGIEPSALEALINFAYSGRIAIDTSNVQSL 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641802973  144 VDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYG--AEIIMDintaGIDMPMFSALLHYLYTGEFGMEDSrfqNVDILV 221
Cdd:cd01165     1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESgqAEINLR----DISPEDFRALLEFLYGGKRDLDAS---NLLELL 73

                  ..
gi 641802973  222 QL 223
Cdd:cd01165    74 EA 75

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641802973  142 TDVDLIFQETCFPVHRAILAARCPFFKTLLSSS-PEYGAEIimdINTAGIDMPMFSALLHYLYTGEFGMEDsrfQNVDIL 220
Cdd:cd18265    24 TDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHlKESRQAV---VEIQKVSAAAMEVLLDYMYGGGLRIQE---DNVESV 97

                          90
                  ....*....|
gi 641802973  221 VQLSEEFGTP 230
Cdd:cd18265    98 LEASDLLQVS 107

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 641802973  128 LQKDMADLYEYKYCTDVDLIFQETCFPVHRAILAARCP--FFKTLLSSSPEYGAEIimdINTAGIDMPMFSALLHYLYT 204
Cdd:cd18285     2 LSQDLLRLLREELHTDVTFYVGSTLFKAHKAILLARVPefFSHIIGKLSSLEDQEP---INIENLEASEFKTFLRQVYT 77

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641802973  124 EARTLQKDMADLyeykyctDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYG-AEIIMDINTAGidmpMFSALLHYL 202
Cdd:cd18231     6 EQRLFQPDLCDV-------DIVLVRQRSTFPAHKGVLAAYSQFFHSLFTQNKQLQrVELSLEALTSQ----GLQQILNFI 74

                          90
                  ....*....|....*
gi 641802973  203 YTGEFGMEDSRFQNV 217
Cdd:cd18231    75 YTSKLLVNSCNVQDV 89

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 641802973  142 TDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEiiMDINTAGIDMPMFSALLHYLYTGE 206
Cdd:cd18268    24 TDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQ--AKVDLKGIDSDVLDQIVDYVYTGE 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 641802973  140 YCtDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDINTAgidmpMFSALLHYLYTGEFGMEDS 212
Cdd:cd18289    29 YC-DVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPATVPPA-----CFQQILSFCYTGKLTMAAS 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641802973  130 KDMADLYEYkycTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSpeygaeiIMDINTAGI---DMPM--FSALLHYLYT 204
Cdd:cd18276    13 NRMKELAEL---TDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTCG-------LMECSQREVvlhDITAesVSIILNYMYS 82