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Conserved domains on  [gi|672038662|ref|XP_008758155|]
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zinc finger protein 771 isoform X1 [Rattus norvegicus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
41-245 1.29e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.02  E-value: 1.29e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672038662  41 SPVDNKEVASQMPVPSADPARPHACPDCGRAF--ARRSTLAKHARTHTGER-----PFACTECGRCFSQKSALTKHGRT- 112
Cdd:COG5048  233 SQLSPKSLLSQSPSSLSSSDSSSSASESPRSSlpTASSQSSSPNESDSSSEkgfslPIKSKQCNISFSRSSPLTRHLRSv 312

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672038662 113 -HTGE--RPYQCPE--CDKRFSAASNLRQHRRRHTGEKPYAC--AHCGRRFAQSSNYAQHLRVH-----TGEKPYAC--P 178
Cdd:COG5048  313 nHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsN 392

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672038662 179 DCGRAFGGSSCLARHRRTHTGERPYAC--ADCGTRFAQSSALAKHRRVHTGEKPHRCAVCG--RRFGHRSN 245
Cdd:COG5048  393 SCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKsfRRDLDLSN 463
zf-H2C2_2 pfam13465
Zinc-finger double domain;
245-268 1.55e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.55e-03
                          10        20
                  ....*....|....*....|....
gi 672038662  245 NLAEHARTHTGERPYPCTECGRRF 268
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
41-245 1.29e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.02  E-value: 1.29e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672038662  41 SPVDNKEVASQMPVPSADPARPHACPDCGRAF--ARRSTLAKHARTHTGER-----PFACTECGRCFSQKSALTKHGRT- 112
Cdd:COG5048  233 SQLSPKSLLSQSPSSLSSSDSSSSASESPRSSlpTASSQSSSPNESDSSSEkgfslPIKSKQCNISFSRSSPLTRHLRSv 312

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672038662 113 -HTGE--RPYQCPE--CDKRFSAASNLRQHRRRHTGEKPYAC--AHCGRRFAQSSNYAQHLRVH-----TGEKPYAC--P 178
Cdd:COG5048  313 nHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsN 392

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672038662 179 DCGRAFGGSSCLARHRRTHTGERPYAC--ADCGTRFAQSSALAKHRRVHTGEKPHRCAVCG--RRFGHRSN 245
Cdd:COG5048  393 SCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKsfRRDLDLSN 463
zf-H2C2_2 pfam13465
Zinc-finger double domain;
133-158 1.64e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 1.64e-04
                          10        20
                  ....*....|....*....|....*.
gi 672038662  133 NLRQHRRRHTGEKPYACAHCGRRFAQ 158
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
245-268 1.55e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.55e-03
                          10        20
                  ....*....|....*....|....
gi 672038662  245 NLAEHARTHTGERPYPCTECGRRF 268
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
41-245 1.29e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.02  E-value: 1.29e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672038662  41 SPVDNKEVASQMPVPSADPARPHACPDCGRAF--ARRSTLAKHARTHTGER-----PFACTECGRCFSQKSALTKHGRT- 112
Cdd:COG5048  233 SQLSPKSLLSQSPSSLSSSDSSSSASESPRSSlpTASSQSSSPNESDSSSEkgfslPIKSKQCNISFSRSSPLTRHLRSv 312

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672038662 113 -HTGE--RPYQCPE--CDKRFSAASNLRQHRRRHTGEKPYAC--AHCGRRFAQSSNYAQHLRVH-----TGEKPYAC--P 178
Cdd:COG5048  313 nHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsN 392

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672038662 179 DCGRAFGGSSCLARHRRTHTGERPYAC--ADCGTRFAQSSALAKHRRVHTGEKPHRCAVCG--RRFGHRSN 245
Cdd:COG5048  393 SCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKsfRRDLDLSN 463
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
89-162 4.60e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 4.60e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672038662  89 RPFACTECGRCFSQKSALTKHGRTHTGERPYQC--PECDKRFSAASNLRQHRRRHTGEKPYACAHCGRRFAQSSNY 162
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASS 107
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 148-254 1.73e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.86  E-value: 1.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672038662 148 ACAHCGRRFAQSSnyAQHLRVhTGEKPYACP--DCGRAFGGSSCLARHRRThtgerpyacADCGTRFAQSSALAKHRRVH 225
Cdd:COG5189  326 KLAHGGERNIDTP--SRMLKV-KDGKPYKCPveGCNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFS 393

                         90       100
                 ....*....|....*....|....*....
gi 672038662 226 TGEKPHRCAVCGRRFGHRSNLAEHaRTHT 254
Cdd:COG5189  394 AKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 115-198 6.81e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 6.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672038662 115 GERPYQCP--ECDKRFSAASNLRQHRRRhtgekpyacAHCGRRFAQSSNYAQHLRVHTGEKPYACPDCGRAFGGSSCLAR 192
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 672038662 193 HrRTHT 198
Cdd:COG5189  417 H-RKHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
59-221 1.09e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 1.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672038662  59 PARPHACP--DCGRAFARRSTLAKHARTHTGERPFACTECGRCFSQKSALTKHGRTHTgerpyqcpecdkrfsaasnlrQ 136
Cdd:COG5048  318 SLKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNEPPQSL---------------------Q 376

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672038662 137 HRRRHTGEKPYACAH--CGRRFAQSSNYAQHLRVHTGEKPYAC--PDCGRAFGGSSCLARHRRTHTGERPYACADCGtRF 212
Cdd:COG5048  377 QYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILK-SF 455


                 ....*....
gi 672038662 213 AQSSALAKH 221
Cdd:COG5048  456 RRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
133-158 1.64e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 1.64e-04
                          10        20
                  ....*....|....*....|....*.
gi 672038662  133 NLRQHRRRHTGEKPYACAHCGRRFAQ 158
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
145-209 3.36e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 3.36e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672038662 145 KPYACAHCGRRFAQSSNYAQHLRVHTGEKPYACPDCGRA--FGGSSCLARHRRTHTGERPYACADCG 209
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNSKSL 98
zf-H2C2_2 pfam13465
Zinc-finger double domain;
245-268 1.55e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.55e-03
                          10        20
                  ....*....|....*....|....
gi 672038662  245 NLAEHARTHTGERPYPCTECGRRF 268
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
105-129 1.66e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.66e-03
                          10        20
                  ....*....|....*....|....*
gi 672038662  105 ALTKHGRTHTGERPYQCPECDKRFS 129
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
161-184 2.00e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.00e-03
                          10        20
                  ....*....|....*....|....
gi 672038662  161 NYAQHLRVHTGEKPYACPDCGRAF 184
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
173-253 2.35e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 2.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672038662 173 KPYACPDCGRAFGGSSCLARHRRTHTGERPYACADCGTRFAQS--SALAKHRRVHTGEKPHRCA--VCGRRFGHRSNLAE 248
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSksLPLSNSKASSSSLS 111


                 ....*
gi 672038662 249 HARTH 253
Cdd:COG5048  112 SSSSN 116
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 119-141 3.85e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 3.85e-03
                          10        20
                  ....*....|....*....|...
gi 672038662  119 YQCPECDKRFSAASNLRQHRRRH 141
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
217-240 4.84e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 4.84e-03
                          10        20
                  ....*....|....*....|....
gi 672038662  217 ALAKHRRVHTGEKPHRCAVCGRRF 240
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 91-113 7.97e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.43  E-value: 7.97e-03
                          10        20
                  ....*....|....*....|...
gi 672038662   91 FACTECGRCFSQKSALTKHGRTH 113
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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