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Conserved domains on  [gi|1046841776|ref|XP_008758631|]
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CUE domain-containing protein 2 isoform X2 [Rattus norvegicus]

Protein Classification

CUE domain-containing protein 2( domain architecture ID 10198899)

CUE domain-containing protein 2 (CUEDC2) is a novel negative regulator of progesterone receptor (PR) and functions to promote the progesterone-induced PR degradation by the ubiquitin-proteasome pathway

Gene Symbol:  CUEDC2
Gene Ontology:  GO:0043130
PubMed:  21976060|12628920

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CUE_CUED2 cd14367
CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins; CUEDC2 is a ...
 126-166 4.43e-13

CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins; CUEDC2 is a novel negative regulator of progesterone receptor (PR) and functions to promote the progesterone-induced PR degradation by the ubiquitin-proteasome pathway. It also acts as the regulator of JAK1/STAT3 signaling through inhibiting cytokine-induced phosphorylation of JAK1 and STAT3 and the subsequent STAT3 transcriptional activity. All members in this subfamily contain a CUE domain.


:

Pssm-ID: 270550  Cd Length: 42  Bit Score: 61.87  E-value: 4.43e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1046841776 126 QPGVDVLLEVFPTCSMEQAQWVLAKARGNLEEAVQMLIEGK 166
Cdd:cd14367     2 KDQVDLLLEMFPSCSSLEAKHCLAVAKGDLEEAVQLLLERQ 42
 
Name Accession Description Interval E-value
CUE_CUED2 cd14367
CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins; CUEDC2 is a ...
 126-166 4.43e-13

CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins; CUEDC2 is a novel negative regulator of progesterone receptor (PR) and functions to promote the progesterone-induced PR degradation by the ubiquitin-proteasome pathway. It also acts as the regulator of JAK1/STAT3 signaling through inhibiting cytokine-induced phosphorylation of JAK1 and STAT3 and the subsequent STAT3 transcriptional activity. All members in this subfamily contain a CUE domain.


Pssm-ID: 270550  Cd Length: 42  Bit Score: 61.87  E-value: 4.43e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1046841776 126 QPGVDVLLEVFPTCSMEQAQWVLAKARGNLEEAVQMLIEGK 166
Cdd:cd14367     2 KDQVDLLLEMFPSCSSLEAKHCLAVAKGDLEEAVQLLLERQ 42
CUE pfam02845
CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE ...
 129-166 8.30e-03

CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE domains are related to pfam00627 and this has been confirmed by the structure of the domain. CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2.


Pssm-ID: 427018  Cd Length: 42  Bit Score: 33.60  E-value: 8.30e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1046841776 129 VDVLLEVFPTCSMEQAQWVLAKARGNLEEAVQMLIEGK 166
Cdd:pfam02845   5 LETLKEMFPDLDEEVIRAVLEASNGNVEAAINALLEGS 42
 
Name Accession Description Interval E-value
CUE_CUED2 cd14367
CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins; CUEDC2 is a ...
 126-166 4.43e-13

CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins; CUEDC2 is a novel negative regulator of progesterone receptor (PR) and functions to promote the progesterone-induced PR degradation by the ubiquitin-proteasome pathway. It also acts as the regulator of JAK1/STAT3 signaling through inhibiting cytokine-induced phosphorylation of JAK1 and STAT3 and the subsequent STAT3 transcriptional activity. All members in this subfamily contain a CUE domain.


Pssm-ID: 270550  Cd Length: 42  Bit Score: 61.87  E-value: 4.43e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1046841776 126 QPGVDVLLEVFPTCSMEQAQWVLAKARGNLEEAVQMLIEGK 166
Cdd:cd14367     2 KDQVDLLLEMFPSCSSLEAKHCLAVAKGDLEEAVQLLLERQ 42
CUE cd14279
CUE domain found in ubiquitin-binding CUE proteins; This family includes many coupling of ...
 129-162 2.64e-04

CUE domain found in ubiquitin-binding CUE proteins; This family includes many coupling of ubiquitin conjugation to endoplasmic reticulum degradation (CUE) domain containing proteins that are characterized by an FP and a di-leucine-like sequence and bind to monoubiquitin with varying affinities. Some higher eukaryotic CUE domain proteins do not bind monoubiquitin efficiently, since they carry LP, rather than FP among CUE domains. CUE domains form three-helix bundle structures and are distantly related to the ubiquitin-associated (UBA) domains which are widely occurring ubiquitin-binding motifs found in a broad range of cellular proteins in species ranging from yeast to human. The majority of family members contain one CUE domain, but some family members from fungi harbor two CUE domains.


Pssm-ID: 270465  Cd Length: 38  Bit Score: 37.45  E-value: 2.64e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1046841776 129 VDVLLEVFPTCSMEQAQWVLAKARGNLEEAVQML 162
Cdd:cd14279     4 LEQLQEMFPDLDEEVLEDVLEANNGDVEAAIDAL 37
CUE pfam02845
CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE ...
 129-166 8.30e-03

CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE domains are related to pfam00627 and this has been confirmed by the structure of the domain. CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2.


Pssm-ID: 427018  Cd Length: 42  Bit Score: 33.60  E-value: 8.30e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1046841776 129 VDVLLEVFPTCSMEQAQWVLAKARGNLEEAVQMLIEGK 166
Cdd:pfam02845   5 LETLKEMFPDLDEEVIRAVLEASNGNVEAAINALLEGS 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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