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Conserved domains on  [gi|672061315|ref|XP_008764282|]
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CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X4 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 117-321 1.94e-143

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467710  Cd Length: 204  Bit Score: 403.28  E-value: 1.94e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 117 CRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHFDPKIENNPDTLLVLVAFKAMD 196
Cdd:cd23982    2 CRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPGIENDPDTLLVLVPFKPLD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 197 FHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPIQqpRKIKQKPTTGLLAITLALHLCDLV 276
Cdd:cd23982   82 FYWLYEILSNEKRVRKGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVPGQ--RKKKQKPTTGLLAITLALHLCDEV 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 672061315 277 HIAGFGYPDAYNKKQTIHYYEQITLKSMAGSGHNVSQEAVAIKRM 321
Cdd:cd23982  160 HIAGFGYPDNGNSNQPIHYYNQITLKSMANSGHNLNAEAQAIQRL 204
 
Name Accession Description Interval E-value
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 117-321 1.94e-143

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 403.28  E-value: 1.94e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 117 CRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHFDPKIENNPDTLLVLVAFKAMD 196
Cdd:cd23982    2 CRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPGIENDPDTLLVLVPFKPLD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 197 FHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPIQqpRKIKQKPTTGLLAITLALHLCDLV 276
Cdd:cd23982   82 FYWLYEILSNEKRVRKGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVPGQ--RKKKQKPTTGLLAITLALHLCDEV 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 672061315 277 HIAGFGYPDAYNKKQTIHYYEQITLKSMAGSGHNVSQEAVAIKRM 321
Cdd:cd23982  160 HIAGFGYPDNGNSNQPIHYYNQITLKSMANSGHNLNAEAQAIQRL 204
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 82-326 6.85e-66

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 208.23  E-value: 6.85e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315   82 SAYELPFgtKGSEDLLLRVLAITSysipesIQSLECRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGS 161
Cdd:pfam00777  16 SEWWLPF--TVTEELLELLPKVSP------FDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315  162 KTTIRLFYPESA------HFDPKIENNPDTLLVLVAFKAMDFHWIETILSdKKRVRKGFWKQP---PLIWDVNPKQIRIL 232
Cdd:pfam00777  88 KTTLRTMNPESAidskygNLGFSHPRDPFVEFVLVPFKGRDLLWLPAFLT-KGNVSRSLRVLYtlkEVKIPVDPDKVLFL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315  233 NPFFMEIAADKLLSLPIQQPRkikqKPTTGLLAITLALHLCDLVHIAGFGyPDAYNKKQTIHYYEQITLKSMAGSG-HNV 311
Cdd:pfam00777 167 HPDFLRYVANFWLRSHGLKGR----RPSTGLLMLSLALHLCDEVSLYGFG-PFLDSRGNSHHYYDNVLMKKGGFYGvHDM 241

                         250
                  ....*....|....*
gi 672061315  312 SQEAVAIKRMLEMGA 326
Cdd:pfam00777 242 PFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 117-321 1.94e-143

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 403.28  E-value: 1.94e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 117 CRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHFDPKIENNPDTLLVLVAFKAMD 196
Cdd:cd23982    2 CRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPGIENDPDTLLVLVPFKPLD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 197 FHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPIQqpRKIKQKPTTGLLAITLALHLCDLV 276
Cdd:cd23982   82 FYWLYEILSNEKRVRKGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVPGQ--RKKKQKPTTGLLAITLALHLCDEV 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 672061315 277 HIAGFGYPDAYNKKQTIHYYEQITLKSMAGSGHNVSQEAVAIKRM 321
Cdd:cd23982  160 HIAGFGYPDNGNSNQPIHYYNQITLKSMANSGHNLNAEAQAIQRL 204
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 117-321 7.33e-111

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 320.78  E-value: 7.33e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 117 CRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHFDPkIENNPDTLLVLVAFKAMD 196
Cdd:cd23967    2 CRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFRDP-EEYDSDWLLVLVPFKSMD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 197 FHWIETILSDKKRV-RKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPIQQpRKIKQKPTTGLLAITLALHLCDL 275
Cdd:cd23967   81 LLWLQAVIKGKKPNgKGGFWKKIATSVPKPPKKIRILNPYILQEAAFDLIGLPMNG-KQGKNVPTTGIIAIVMALHYCDE 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 672061315 276 VHIAGFGYPDAyNKKQTIHYYEQITLKSMAGS-GHNVSQEAVAIKRM 321
Cdd:cd23967  160 VDIAGFGYDPS-DPNAPLHYYDSLTMKAIKRSwTHNVTKEKKYLKKL 205
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 117-321 3.30e-80

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 242.73  E-value: 3.30e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 117 CRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHFDPkIENNPDTLLVLVAFKAMD 196
Cdd:cd23984    2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDP-SHYDPNTTVVLIPFKPHD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 197 FHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPIQQPR-KIKQKPTTGLLAITLALHLCDL 275
Cdd:cd23984   81 LRWLLDLLMGKKVSAKGFWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPKRFPKeKKPKHPTTGIIAITLALHICNE 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 672061315 276 VHIAGFGYpDAYNKKQTIHYYEQITLKSMAGSG-HNVSQEAVAIKRM 321
Cdd:cd23984  161 VHIAGFKY-DFSNLNSTLHYYGNETMSVMTKNEyHNISAEQKFLKDL 206
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 82-326 6.85e-66

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 208.23  E-value: 6.85e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315   82 SAYELPFgtKGSEDLLLRVLAITSysipesIQSLECRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGS 161
Cdd:pfam00777  16 SEWWLPF--TVTEELLELLPKVSP------FDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315  162 KTTIRLFYPESA------HFDPKIENNPDTLLVLVAFKAMDFHWIETILSdKKRVRKGFWKQP---PLIWDVNPKQIRIL 232
Cdd:pfam00777  88 KTTLRTMNPESAidskygNLGFSHPRDPFVEFVLVPFKGRDLLWLPAFLT-KGNVSRSLRVLYtlkEVKIPVDPDKVLFL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315  233 NPFFMEIAADKLLSLPIQQPRkikqKPTTGLLAITLALHLCDLVHIAGFGyPDAYNKKQTIHYYEQITLKSMAGSG-HNV 311
Cdd:pfam00777 167 HPDFLRYVANFWLRSHGLKGR----RPSTGLLMLSLALHLCDEVSLYGFG-PFLDSRGNSHHYYDNVLMKKGGFYGvHDM 241

                         250
                  ....*....|....*
gi 672061315  312 SQEAVAIKRMLEMGA 326
Cdd:pfam00777 242 PFEFKLLQKLHKEGV 256
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 117-321 1.81e-65

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 205.36  E-value: 1.81e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 117 CRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAhfdPK--IENNPDTLLVLVAFKA 194
Cdd:cd23983    2 CRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGA---PKseQEYDPTSLFVAVLFKS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 195 MDFHWIETILSDKKR---VRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPIQQPR---KIKQKPTTGLLAITL 268
Cdd:cd23983   79 VDFAWLKAMVKKEPLsfwSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQYPEPQSRlwgWDKNVPTLGVTAVVL 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 672061315 269 ALHLCDLVHIAGFGYpDAYNKKQTIHYYEQITLKSMAGSG-HNVSQEAVAIKRM 321
Cdd:cd23983  159 ATHLCDEVSLAGFGY-DLSQPHAPLHYYDSVCMAAMNTQTmHNVTKETKFLKKL 211
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 117-321 5.40e-58

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 186.28  E-value: 5.40e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 117 CRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHFDPKiENNPDTLLVLVAFKAMD 196
Cdd:cd23981    2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPE-QYEKDSLFVLAGFKWQD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 197 FHWIETIL-SDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPIQQPRKIKQK-PTTGLLAITLALHLCD 274
Cdd:cd23981   81 FKWLKYIVyKEKVSASDGFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPFNNGLMGRGNiPTLGSVAITMALHNCD 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 672061315 275 LVHIAGFGYpDAYNKKQTIHYYEQITLKSMAGS-GHNVSQEAVAIKRM 321
Cdd:cd23981  161 EVAVAGFGY-DMNTPNAPLHYYETIKMSAIKESwTHNIQREKEFLRKL 207
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 117-328 1.59e-45

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 156.29  E-value: 1.59e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 117 CRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESA-HFDpkiennPDTLLVLVAFKAM 195
Cdd:cd23966   77 CRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESAvDLD------PGVHLVLVPFKVL 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 196 DFHWIETILSDKKRVRKgfWKQPPLIWDVNPKQIRILNPFFMEIAADKLLslpiqqpRKIKQKPTTGLLAITLALHLCDL 275
Cdd:cd23966  151 DLQWLISALTTGEITRT--YTPVKRFIKADKDKVLVINPAFIKYVHDNWT-------EHHGRYPSTGFLALIFALHICDE 221

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 276 VHIAGFGypdAYNKKQTIHYYEQitlksMAGSG-------HNVSQEAVAIKRMLEMGAVK 328
Cdd:cd23966  222 VSVFGFG---ADSKGNWHHYWEK-----NRSAGafrktgvHDADFESDIIKKLAKEGKIR 273
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 67-328 3.87e-41

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 145.09  E-value: 3.87e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315  67 PIFLQLKDYF--WVKTPSAYELPFGTKG-SEDLLLRVLAITSYSIPESIQSLE-----CRRCVVVGNGHRLKNSSLGGVI 138
Cdd:cd23964   24 KVLLDSEDFNpeEYNRLSHYKLPFGWGGlNREVVERLLRNLNLTSSRYMFVLRggrprCIRCAVVGNGGILNGSGKGKEI 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 139 NKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAH----FDPKIENnpDTLLVLVAFKAMDFHWIETILSDKKRVR--- 211
Cdd:cd23964  104 DAHDYVFRVNHALTKGFEKDVGTKTSFYTFFPESLHnsllKHVPQDK--DTKYLFIPFKIRDYDYLDAVLSGKPVPDgcd 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 212 KGFWKQPPLIWDVNPKQIRILNPFFME-IAADKLLSLPIqqprkikQKPTTGLLAITLALHLCDLVHIAGFGypdaYNKK 290
Cdd:cd23964  182 KGKRPPPLFGPKLNATNVRLLHPDFIRyLFNRWLNSSTS-------YRPTTGALMLLTALHTCDQVSVYGFG----YDPR 250

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 672061315 291 QTIHYYE-QITLKSMAGSGHNVSQEAVAIKRMLEMGAVK 328
Cdd:cd23964  251 FSLHYYDkTFVKFTVFYANHDFTNERKLWRKLHEEGIIN 289
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 120-321 1.68e-38

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 135.18  E-value: 1.68e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 120 CVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHF--------DPKIENNPDTLLVLVA 191
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFylrgprcgCHPLPLEEEVVLILSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 192 FKAMDFHWIetilsdkKRVRKGFWKQPPLiwdVNPKQIRILNpFFMEIaADKLLSLPIQQPRkikqKPTTGLLAITLALH 271
Cdd:cd19952   81 AAAADFKRL-------KRRKKRHDNAVLL---LTDPAPDLLS-YVRKR-LEKLGLKSFFGGN----APSSGLLAVLLALQ 144

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 672061315 272 LCDLVHIAGFGYPDAYNKKQTIHYYEQITLKSMAGSgHNVSQEAVAIKRM 321
Cdd:cd19952  145 LCDSVDLYGFGVDSGHAPKVPYHYYDLVEAEEGTAV-HSFDLEAELLRAL 193
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 114-297 9.27e-31

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 117.29  E-value: 9.27e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 114 SLECRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHfdpkiENNPDTLLVLVAFK 193
Cdd:cd23980   78 LVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESFR-----ELAQNVSMILVPFK 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 194 AMDFHWIETILSdKKRVRKGFWKQPPLIwDVNPKQIRILNPFFMEIAADKLLslpiqqpRKIKQKPTTGLLAITLALHLC 273
Cdd:cd23980  153 TLDLEWVISATT-TGTISHTYVPVPRKI-KVKKEKILIYHPAFIKYVFDRWL-------QGHGRYPSTGILSVIFSLHVC 223

                        170       180
                 ....*....|....*....|....
gi 672061315 274 DLVHIAGFGypdAYNKKQTIHYYE 297
Cdd:cd23980  224 DEVDLYGFG---ADSKGNWHHYWE 244
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 115-298 2.05e-30

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 116.51  E-value: 2.05e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 115 LECRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHFDPkiennPDTLLVLVAFKA 194
Cdd:cd23979   78 SRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAKNLP-----ANVSFVLVPFKT 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 195 MDFHWIETILSdKKRVRKGFWKQPPLIwDVNPKQIRILNPFFMEIAADKLlslpiqqPRKIKQKPTTGLLAITLALHLCD 274
Cdd:cd23979  153 LDLLWITSALS-TGQIRFTYAPVKQFL-RVDKDKVQIYNPAFFKYIHDRW-------TEHHGRYPSTGMLVLFFALHVCD 223

                        170       180
                 ....*....|....*....|....
gi 672061315 275 LVHIAGFGypdAYNKKQTIHYYEQ 298
Cdd:cd23979  224 EVNVYGFG---ADSRGNWHHYWEN 244
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 118-328 4.84e-26

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 104.65  E-value: 4.84e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 118 RRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKT---TI------RLFYPESAHFDPK-----IENNP 183
Cdd:cd23963   64 KTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTnltTLnpsilkRRYNSLKKNRDRDkflnrLKEYN 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 184 DTLLVLVAFkamdfhwietilSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLlslpiqQPRKIKQKPTTGL 263
Cdd:cd23963  144 GSILWYPKF------------SFKSSTNLLLKAARALKKNGLNLTVVYSNPEHFLAVQKFW------KRRGLEKRPSTGL 205

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672061315 264 LAITLALHLCDLVHIAGFgYP---DAYNKKQTIHYYEQITLKSMAGSgHNVSQEAVAIKRMLEMGAVK 328
Cdd:cd23963  206 YLVSLALTFCDEIHLYGF-WPfptDPNGRPVPYHYYDDLSPSTKNKV-HNMPEEFKLLRELHKKGVLK 271
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 118-321 9.97e-25

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 100.81  E-value: 9.97e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 118 RRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRL-----FYPESAHFDPKIENNPDTLLV---- 188
Cdd:cd23968   46 NTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLRLinsqiLSKPEFNFLTDPLYRNVTLLVwdps 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 189 ------LVAFKAMDFHWIET-----ILSDKKRVrkgFWKQPPLIWDVnpkqIRILNPFFmeiaadkllslpiqqPRKIKQ 257
Cdd:cd23968  126 synvnlEKWYKKPDFDFFPNyikyrRRHPEEPF---YLIDPRFLWRL----WDILQEYT---------------PEKIKP 183

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672061315 258 K-PTTGLLAITLALHLCDLVHIAGFGYPDAYNKKqtIHYYEQITLKSMA-GSGHNVSQEAVAIKRM 321
Cdd:cd23968  184 NpPSSGFIGIVLMLHLCDWVDVYEYVPSVRQTDR--CHYYDVEKDLACTlGAWHPLAAEKLLVRHL 247
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 114-295 1.16e-23

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 98.67  E-value: 1.16e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 114 SLECRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTirlFYPESAH-------------FDpKIE 180
Cdd:cd23973   80 GDGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTS---FYVHTAHsitsslmilqkrgFK-NIP 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 181 NNPDTLLVLVAFKAMDFHWIETILSDKKRVRKGFWKQPPLIW---DVNPKQIRILNPFFMEIAADKLL-SLPIQQPRKIK 256
Cdd:cd23973  156 QDKDIKYILFPEGPRDYQWLEALLKNKTIPSGAYYGRRPRSYfsgDFTEDKYLVLHPDFLRYVKNRFLrSKTLKGKYWAI 235

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 672061315 257 QKPTTGLLAITLALHLCDLVHIAGF------GYPDAY---NKKQTIHY 295
Cdd:cd23973  236 YRPTTGAFLLLTALHLCDTVSAYGFitedyrKYPDHYydkKKTKLVFY 283
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 71-297 1.49e-21

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 92.08  E-value: 1.49e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315  71 QLKDYFWVKTPSAYELPFGTKGSEDLLlrvlaiTSYSIPESIQSLecRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNA 150
Cdd:cd23985    7 ELKDKVNVSMLEGTDFPFNTSEWEGYL------PKKSLREEVGPL--GRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 151 PVAGYEGDVGSKTTIRLFYP-----ESAHFDPKIENNPDTLLVL--VAFKAMDFHWIET----ILSDKKRVRKgfwkqpp 219
Cdd:cd23985   79 PTAGFQQDVGTKTTIRLINSqlvttEKHKFLKDSLYNEGILIVWdpAPYHSDIPEWYKNpdynFFENYKTYRR------- 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 220 liwdVNPKQ-IRILNPFF--------MEIAADKllslpIQqprkiKQKPTTGLLAITLALHLCDLVHIAGFgYPdayNKK 290
Cdd:cd23985  152 ----LNPNQpFYILHPQMqwelwdiiQENSPEE-----IQ-----PNPPSSGMLGIILMMTLCDQVDVYEF-LP---SKR 213


                 ....*....
gi 672061315 291 QT--IHYYE 297
Cdd:cd23985  214 KTdvCHYYQ 222
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 117-302 4.42e-20

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 87.30  E-value: 4.42e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 117 CRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFypesAHFD-PKIENNPDTLLVLVAFKAM 195
Cdd:cd23965    1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVV----SHSSlPRLLRNAILLLAGTRAPTV 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 196 DFHWietiLSDKKRVRKGFwKQPPLIW---DVNPK-QIRILNPfFMEIAADKLLSLPIQQPRKI-KQKPTTGLLAITLAL 270
Cdd:cd23965   77 VVFW----GPETKMNKDGA-GKYNLLRslsKKYPDvEFYSLTP-EKMDYADELFEKETGKSRIKsGTWLSTGWFTMLLAL 150

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 672061315 271 HLCDLVHIAGFGYPDaY-----NKKQTIHYYEQITLK 302
Cdd:cd23965  151 DVCDEIKVYGMVPEN-YcrehpNSKVPYHYYEPGGLK 186
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 116-328 1.30e-18

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 84.80  E-value: 1.30e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 116 ECRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFY-------------------PESAH-- 174
Cdd:cd23974   83 PCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFStntlmnslrayagvgfngpPQSKEtr 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 175 --FDPkiENNPDTLLVLVAfkamdfhwIETILSDKKRVRKgfwKQPPLIW--DVNPKQIRILNPFFMEIAADKLLSLPIQ 250
Cdd:cd23974  163 yiFLP--DHDRDYLLVKAA--------LTHTPIDRGRDKS---KRPSKYFgkDVTAEKFKIYHPDFIRYLRNRFLWSPIL 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 251 QP--RKIkQKPTTGLLAITLALHLCDLVHIAGFGYPDaYNKKQTiHYYEQITLKSMAGSGHNVSQEAVAIKRMLEMGAVK 328
Cdd:cd23974  230 NTkqRDI-YRPSTGAVMLLAALHTCDQVSAYGFMTPD-YGKYSD-HYYDKTYHKVVFYANHDLRLEMQLWQKLHKAGLIK 306
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 63-321 1.37e-18

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 84.12  E-value: 1.37e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315  63 SREQpIFLQLKDYFWVKTPSAYELPFGTKGSEDLLLRvlaitsysIPES-IQSLECRRCVVVGNGHRLKNSSLGGVINKY 141
Cdd:cd23986    3 SRQE-LLCELKKRVQVRTLDGKEAPFSALGWEKYVPK--------IPLSkLHLRGFRSCAVVTSAGAILNSSLGKEIDSH 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 142 DVVIRLNNAPVAGYEGDVGSKTTIRLFYPE-----SAHFdpkIENNPDTLLVLVAFK----AMDFH-WIE----TILSDK 207
Cdd:cd23986   74 DAVLRFNSAPTRGYEKDVGNKTTIRIINSQiltnpNHHF---IDSSLYKDVILVAWDpapySANLHkWYKkpdyNLFTPY 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 208 KRVRKGFWKQPPLIwdVNPKQIRILNPFFMEIAADKLlslpiqQPrkikQKPTTGLLAITLALHLCDLVHIagFGYPDAY 287
Cdd:cd23986  151 VQYRKRNPNQPFYI--LHPKFIWQLWDIIQENTQEKI------QP----NPPSSGFIGILIMMSMCREVHV--YEYIPSV 216

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 672061315 288 NKKQTIHYYEQ-----ITLksmaGSGHNVSQEAVAIKRM 321
Cdd:cd23986  217 RQTDLCHYHERyydaaCTL----GAYHPLLYEKLLIQRM 251
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 118-331 4.52e-18

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 82.46  E-value: 4.52e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 118 RRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIrlfypesahfdpkIENNPDtlLVLVAFKAMDF 197
Cdd:cd23969   65 RTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNL-------------TTMNPS--VIPHAYGDLVN 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 198 -HWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNpffmEIAADKLLSLPIQQP-----RKIK----------QKPTT 261
Cdd:cd23969  130 aTDKEKFVERLRQLGDSILWIPAFVSKGGEEHVQWTN----EIILKHKLNVKTAYPplrlnHAIRgywlttkfriKRPST 205

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672061315 262 GLLAITLALHLCDLVHIAGFgYP---DAYNKKQTIHYYEQITLKSMAgSGHNVSQEAVAIKRMLEMGAVKNLT 331
Cdd:cd23969  206 GLLMYTLATRFCDEIHLYGF-YPfseDGNGRAVKYHYYDNRKYLTTA-RPHKMPEEFRALRSLHQRGALRLHT 276
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 108-328 3.38e-16

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 77.43  E-value: 3.38e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 108 IPES--IQSLECRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHfdpKIENNPDT 185
Cdd:cd23970   57 LPEVspFQNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNPSILE---KYYNNLLT 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 186 LLVLVAFkamdfhwietiLSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPI---------------- 249
Cdd:cd23970  134 IQDRNNF-----------FLSLKKLDGAILWIPAFFFHTSATVTRTLVDFFVEHRGQLKVQLAWpgnimqhvnrywktkh 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 250 QQPRKIkqkpTTGLLAITLALHLCDLVHIAGFgYPDAYNKKQT---IHYYEQITLKSMAG--SGHNVSQEAVAIKRMLEM 324
Cdd:cd23970  203 LSPKRL----STGILMYTLASAICEEIHLYGF-WPFGFDPTGTplpYHYYDKKGTKFTTKwqESHQLPAEFVLLYKMHGA 277


                 ....
gi 672061315 325 GAVK 328
Cdd:cd23970  278 GVLK 281
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 99-328 4.32e-16

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 76.92  E-value: 4.32e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315  99 RVLAITS--YSIPESIQSLECRR---CVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYP--- 170
Cdd:cd23988   41 RTLNISQnlHSLLPEVSPMKNRRfktCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPsvv 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 171 -----------ESAHFDPKIENNPDTLLVLVAF--KAMDFH--WI-ETILSDKKRVRKGFwkqPPLiwdvnpKQIRILNP 234
Cdd:cd23988  121 qrafggfrnesDREKFVHRLSMLNDSVLWIPAFmvKGGEKHveWVnALILKNKLKVRTAY---PSL------RLIHAVRG 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 235 FFMeiaADKllsLPIqqprkikQKPTTGLLAITLALHLCDLVHIAGF-GYP-DAYNKKQTIHYYEQITLKSMAGSG-HNV 311
Cdd:cd23988  192 YWL---TNK---VNI-------KRPSTGLLMYTLATRFCDEIHLYGFwPFPkDANGNPVKYHYYDDLKYRYFSNAGpHRM 258

                        250
                 ....*....|....*..
gi 672061315 312 SQEAVAIKRMLEMGAVK 328
Cdd:cd23988  259 PLEFKTLNVLHNRGALK 275
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 82-328 2.13e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 75.63  E-value: 2.13e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315  82 SAYELPFGTKG--SEDL--LLRVLAITSYS--IPESIQSLECRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGY 155
Cdd:cd23972   41 SQRKVPYGWKGlsHQVVasTLSLLNDSANAklFFPRDTPGKCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGF 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 156 EGDVGSKTTirlFYpesaHFDPKIENNPdtllvLVAFKAMDFH-----------WIETILSDKKRVRKGFWKQP-PLIWD 223
Cdd:cd23972  121 EEDVGTKTS---FY----GFTVNTMKNS-----LISYWNLGFTrtpqgqdlqyiFIPSDIRDYVMLRSAILGVPvPEGLD 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 224 ------------VNPKQIRILNPFFMEIAADKLL-SLPIQQPRKIKQKPTTGLLAITLALHLCDLVHIAGFGYPDaYNKK 290
Cdd:cd23972  189 kgdrphkyfgpeASAKKFKLLHPDFISYLTDRFLkSKLLNTHYGHLYMPSTGALMLLTALHTCDQVSAYGFITSN-YWKF 267

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 672061315 291 QTiHYYEQITLKSMAGSGHNVSQEAVAIKRMLEMGAVK 328
Cdd:cd23972  268 SD-HYYERKKKPLVFYANHDMLLEAALWRRLHKAGILQ 304
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 119-328 1.29e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 72.68  E-value: 1.29e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 119 RCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAgYEGDVGSKTT--------IRLFYPE----SAHFDPKIENNPDTL 186
Cdd:cd23971   66 TCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVGSKTNlvtanpsiLREKFHNlkkrRRPFVERMKVYGNAL 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 187 LVLVAFKamdFHwIETILSDK-KRVRKGFWKQPPLIWdVNPKQIRILNPFFmeiaadklLSLPIQQPRkikqkPTTGLLA 265
Cdd:cd23971  145 LLLPAFS---YT-SNTEPSLRaLYTLEDFGSPQKVLF-FNPEYLRNLSRYW--------KSKGLKARR-----LSTGLML 206

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672061315 266 ITLALHLCDLVHIAGFgYP---DAYNKKQTIHYYEQItlksMAGSG-HNVSQEAVAIKRMLEMGAVK 328
Cdd:cd23971  207 VSAALELCENVHLYGF-WPfstDLDGNPISHHYYDNV----LPKKGvHAMPEEFLRYLKLHSQGVLR 268
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 117-297 1.41e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 69.11  E-value: 1.41e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 117 CRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHfdpKIENNPDTLLVLVAFKAMD 196
Cdd:cd23978    1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVY---RVLRRPQEFLNRTPETTLI 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 197 FhW--IETILSDKKRVRKGFWKQPPLI------WDVNPKQIRILNPFF-MEIAADKllslpiqqpRKIKQKPTTGLLAIT 267
Cdd:cd23978   78 F-WgpPNKMQKDGKSNLFRIIQRASMTfpnmsaFVVSPRRMRQFDDLFrGETGRDR---------KKSHSWLSTGWFTMV 147

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 672061315 268 LALHLCDLVHIAGFGYPDAYNKKQTI-----HYYE 297
Cdd:cd23978  148 IAVELCDNVHVYGMVPPNYCSKRPTPkkmpyHYYE 182
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 120-328 1.92e-13

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 69.58  E-value: 1.92e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 120 CVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYP---ESAHFDPKIENNPDTLLVLVAFKAMD 196
Cdd:cd23987   67 CAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPsvvQRAFEDLVNETWKEKFLQRLQSLNGS 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 197 FHWIETILSDKKRVRKGFWKQPPLIWDVNPK----QIRILNPFFMEIAADKLLslpiqqprkIKqKPTTGLLAITLALHL 272
Cdd:cd23987  147 ILWIPAFMAKGGEERVEWVNDLILKHHINVRtaypSLRLLHAVRGYWLTNKVH---------IK-RPTTGLLMYTLATRF 216

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 273 CDLVHIAGFgYP---DAYNKKQTIHYYEQITLK-SMAGSGHNVSQEAVAIKRMLEMGAVK 328
Cdd:cd23987  217 CNRIHLYGF-WPfprDQNQNPVKYHYYDSLKYGyTSQASPHTMPLEFKALKNLHQQGALK 275
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 118-328 4.08e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 65.55  E-value: 4.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 118 RRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEG-DVGSKTT--------IRLFYPE----SAHFDPKIENNPD 184
Cdd:cd23991   65 KQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGNISkDVGSKTNlvtanpsiISIKYAKlnerRKPFLETVSVYGD 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 185 TLLVLVAFK-----AMDFHWIETILSDKKRVRKGFWkqppliwdvNPKQIRILNPFFmeiaadklLSLPIQQPRKikqkp 259
Cdd:cd23991  145 AFLLLPAFSyrsntALSFKVYYTLEDFKAKQKVIFF---------HPIYLKHLAQFW--------RSKGVQVYRL----- 202

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 672061315 260 TTGLLAITLALHLCDLVHIAGFgYPDAYN---KKQTIHYYEQITLKSmagSGHNVSQEAVAIKRMLEMGAVK 328
Cdd:cd23991  203 STGLMITSAALELCEEVKLYGF-WPFSKNtegKPISHHYYDNQLPKP---GFHSMPKEFYQLLQLHSKGILK 270
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 117-167 8.02e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 61.03  E-value: 8.02e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 672061315 117 CRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRL 167
Cdd:cd23977    1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRV 51
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 115-297 5.41e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 58.73  E-value: 5.41e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 115 LECRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHfdpKIENNPDTLLVlVAFKA 194
Cdd:cd23976   13 MHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQ---RILRNRNELLN-VSQGT 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 195 MDFHWIETilSDKKRVRKGF-WKQPPLIWDVNPK-QIRILNPFFMeIAADKLLSLPIQQPRKIKQK-PTTGLLAITLALH 271
Cdd:cd23976   89 VFIFWGPS--NYMRRDGKGLvYNNLQLMNQILPKlKVYTITRHKM-LQFDELFKRETGKDRKISNTwLSTGWFTMIIALE 165

                        170       180       190
                 ....*....|....*....|....*....|
gi 672061315 272 LCDLVHIAGFGYP----DAYNKKQTIHYYE 297
Cdd:cd23976  166 LCDRINVYGMVPPdfcrDPNHPSVPYHYYE 195
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 115-299 1.55e-09

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 57.92  E-value: 1.55e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 115 LECRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVA-GYEGDVGSKTTIRLFYPESahfdpkIENNPDTLL-----V 188
Cdd:cd23989   61 LPLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPLSrEYTDDVGTKTQLVTANPSI------IDKRFQNLLwsrksF 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 189 LVAFKAMDFHWIET-ILSDKKRVRKGFWKQPPLIwDVNPKQIRIL-NPFFMEiaadkllslPIQQPRKIK----QKPTTG 262
Cdd:cd23989  135 VESMKVYGRSYIYMpAFSMKTGTDPSLRVYYTLA-DVGANQTVLFaNPNFLR---------NVGKFWKSKgvhaKRLSTG 204

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 672061315 263 LLAITLALHLCDLVHIAGFgYP---DAYNKKQTIHYYEQI 299
Cdd:cd23989  205 LFLVSAALGLCEEVTIYGF-WPfsvDLDERTISHHYYDNV 243
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 118-299 1.15e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 55.23  E-value: 1.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 118 RRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAG-YEGDVGSKTTIRLFYP----ESAH--------FDPKIENNPD 184
Cdd:cd23990   65 KKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPISEkYVRDVGVKTDVVTINPsiitERFHklekwrrpFYEVLQVYEN 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672061315 185 TLLVLVAFkamdFHWIETILSDK-KRVRKGFwkqppliwdVNPKQIRILNPFFMEIAADKLLSLPIQQPRkikqkPTTGL 263
Cdd:cd23990  145 ASVVLPAF----YNTRNTDVSIRvKYVLDDF---------ESQQAVYYFHPQYLLNVSRFWLRQGVRAKR-----ISSGL 206

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 672061315 264 LAITLALHLCDLVHIAGF-GYP-DAYNKKQTIHYYEQI 299
Cdd:cd23990  207 MLVTAALELCEEVHLYGFwAFPmNPSGIFITHHYYDNV 244
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 117-184 1.27e-07

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 51.47  E-value: 1.27e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672061315 117 CRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAhfdPKIENNPD 184
Cdd:cd23975    1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSV---PLLLKNPD 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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