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Conserved domains on  [gi|672064757|ref|XP_008765200|]
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myelin-associated neurite-outgrowth inhibitor isoform X1 [Rattus norvegicus]

Protein Classification

TCRP1 domain-containing protein( domain architecture ID 12171678)

TCRP1 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TCRP1 pfam14944
Tongue Cancer Chemotherapy Resistant Protein 1; This family of proteins are found in ...
1-213 2.63e-76

Tongue Cancer Chemotherapy Resistant Protein 1; This family of proteins are found in eukaryotes. Tongue Cancer Chemotherapy Resistant-associated Protein 1 (TCRP1) is resistant to the chemotherapy drug, cisplatin, which induces apoptosis in tumour cells. There is suggestion that TCRP1 can be targeted to reverse chemotherapy resistance. The precise mechanism of TCRP1 inducing resistance against chemotherapy is still not clear, but it is thought that TCRP1 alters cell signalling pathways affecting apoptosis or DNA repair capacity. Proteins in this family are typically between 194 and 235 amino acids in length.


:

Pssm-ID: 434335 [Multi-domain]  Cd Length: 237  Bit Score: 229.43  E-value: 2.63e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672064757    1 MNPVYSPGSSGVPYANAKGIGYPAGFPVGY-AAAPAYSPNMYPGANPTFQTVLEIEPRVL-------------------- 59
Cdd:pfam14944   1 MNPVYSPVQPGVPYGNPKGMAYPAGFPVGYaAAAPAYTPNMYPGASPGFPPGEQLHESAWggfsshsndrsclsfkcdqg 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672064757   60 ----------HMLGYTPGTPYKVSCSPTSGAVPPYSSSPNPYQTAVYPVRSAYPQQSPYAqlslfspQQGTYYTQPLYAA 129
Cdd:pfam14944  81 tkrrtltsssAAFRYTPGTPYKVSPSPSNGAVPPYSSSPNPYPTAVYPIRSAYPQQNPYA-------QQGAYYTQPLYAA 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672064757  130 PPHVIHHTTVVQPNGMPATVYPAPIPPPRGSGVTMGMVAGTTMAMSAGTLLTAHSPTPVAPHPVTVPTYRAPGTPTYSYV 209
Cdd:pfam14944 154 QPHVIHHTTVVQPNGMPAAMYPAPIPPPRNNGVAMGMVAGTTMAMSAGTLLTTPSPTPVGPHPVTVPTYRPPGTPTYSYV 233

                  ....
gi 672064757  210 PPQW 213
Cdd:pfam14944 234 PPQW 237
 
Name Accession Description Interval E-value
TCRP1 pfam14944
Tongue Cancer Chemotherapy Resistant Protein 1; This family of proteins are found in ...
1-213 2.63e-76

Tongue Cancer Chemotherapy Resistant Protein 1; This family of proteins are found in eukaryotes. Tongue Cancer Chemotherapy Resistant-associated Protein 1 (TCRP1) is resistant to the chemotherapy drug, cisplatin, which induces apoptosis in tumour cells. There is suggestion that TCRP1 can be targeted to reverse chemotherapy resistance. The precise mechanism of TCRP1 inducing resistance against chemotherapy is still not clear, but it is thought that TCRP1 alters cell signalling pathways affecting apoptosis or DNA repair capacity. Proteins in this family are typically between 194 and 235 amino acids in length.


Pssm-ID: 434335 [Multi-domain]  Cd Length: 237  Bit Score: 229.43  E-value: 2.63e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672064757    1 MNPVYSPGSSGVPYANAKGIGYPAGFPVGY-AAAPAYSPNMYPGANPTFQTVLEIEPRVL-------------------- 59
Cdd:pfam14944   1 MNPVYSPVQPGVPYGNPKGMAYPAGFPVGYaAAAPAYTPNMYPGASPGFPPGEQLHESAWggfsshsndrsclsfkcdqg 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672064757   60 ----------HMLGYTPGTPYKVSCSPTSGAVPPYSSSPNPYQTAVYPVRSAYPQQSPYAqlslfspQQGTYYTQPLYAA 129
Cdd:pfam14944  81 tkrrtltsssAAFRYTPGTPYKVSPSPSNGAVPPYSSSPNPYPTAVYPIRSAYPQQNPYA-------QQGAYYTQPLYAA 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672064757  130 PPHVIHHTTVVQPNGMPATVYPAPIPPPRGSGVTMGMVAGTTMAMSAGTLLTAHSPTPVAPHPVTVPTYRAPGTPTYSYV 209
Cdd:pfam14944 154 QPHVIHHTTVVQPNGMPAAMYPAPIPPPRNNGVAMGMVAGTTMAMSAGTLLTTPSPTPVGPHPVTVPTYRPPGTPTYSYV 233

                  ....
gi 672064757  210 PPQW 213
Cdd:pfam14944 234 PPQW 237
 
Name Accession Description Interval E-value
TCRP1 pfam14944
Tongue Cancer Chemotherapy Resistant Protein 1; This family of proteins are found in ...
1-213 2.63e-76

Tongue Cancer Chemotherapy Resistant Protein 1; This family of proteins are found in eukaryotes. Tongue Cancer Chemotherapy Resistant-associated Protein 1 (TCRP1) is resistant to the chemotherapy drug, cisplatin, which induces apoptosis in tumour cells. There is suggestion that TCRP1 can be targeted to reverse chemotherapy resistance. The precise mechanism of TCRP1 inducing resistance against chemotherapy is still not clear, but it is thought that TCRP1 alters cell signalling pathways affecting apoptosis or DNA repair capacity. Proteins in this family are typically between 194 and 235 amino acids in length.


Pssm-ID: 434335 [Multi-domain]  Cd Length: 237  Bit Score: 229.43  E-value: 2.63e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672064757    1 MNPVYSPGSSGVPYANAKGIGYPAGFPVGY-AAAPAYSPNMYPGANPTFQTVLEIEPRVL-------------------- 59
Cdd:pfam14944   1 MNPVYSPVQPGVPYGNPKGMAYPAGFPVGYaAAAPAYTPNMYPGASPGFPPGEQLHESAWggfsshsndrsclsfkcdqg 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672064757   60 ----------HMLGYTPGTPYKVSCSPTSGAVPPYSSSPNPYQTAVYPVRSAYPQQSPYAqlslfspQQGTYYTQPLYAA 129
Cdd:pfam14944  81 tkrrtltsssAAFRYTPGTPYKVSPSPSNGAVPPYSSSPNPYPTAVYPIRSAYPQQNPYA-------QQGAYYTQPLYAA 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672064757  130 PPHVIHHTTVVQPNGMPATVYPAPIPPPRGSGVTMGMVAGTTMAMSAGTLLTAHSPTPVAPHPVTVPTYRAPGTPTYSYV 209
Cdd:pfam14944 154 QPHVIHHTTVVQPNGMPAAMYPAPIPPPRNNGVAMGMVAGTTMAMSAGTLLTTPSPTPVGPHPVTVPTYRPPGTPTYSYV 233

                  ....
gi 672064757  210 PPQW 213
Cdd:pfam14944 234 PPQW 237
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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