NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|672064919|ref|XP_008765258|]
View 

MIT domain-containing protein 1 isoform X3 [Rattus norvegicus]

Protein Classification

BREX system Lon protease-like protein BrxL( domain architecture ID 10119420)

BREX system Lon protease-like protein BrxL is part of the phage resistance system BREX (BacteRiophage EXclusion) that employs a defense strategy involving DNA methylation of the host cell and blocking phage DNA replication

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MIT_C super family cl02780
MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and ...
 100-198 3.06e-53

MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown.


The actual alignment was detected with superfamily member pfam16565:

Pssm-ID: 470673  Cd Length: 137  Bit Score: 166.93  E-value: 3.06e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672064919  100 GFSYESLFREYLQETVTEVWIEDPYIRQTHQLYNFLRFCEMLIKKPCKVRTIHLLTSGDEGFGnTQQSSGLEEIKQSLRS 179
Cdd:pfam16565   1 GYSYESLFGPYLDGTATEITIEDPYIRAPHQIRNLVRFCELLVKKCGNLKKIHLLTGEDEENL-DQQLDNLEELKDSLAS 79

                          90
                  ....*....|....*....
gi 672064919  180 HGVVLEINYSSSIHDREIR 198
Cdd:pfam16565  80 RGVTLTVEFSSTLHDREIR 98
MIT_1 cd02683
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 10-86 1.04e-39

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with unknown function, co-occuring with an as yet undescribed domain. The molecular function of the MIT domain is unclear.


:

Pssm-ID: 239146  Cd Length: 77  Bit Score: 130.24  E-value: 1.04e-39
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672064919  10 SDSTAAVAVLKRAVELDAESRYQQALVCYQEGIDMLLQVLKGTKESSKRSTLRTKISGYMDRAENIKKYLDQEKEDG 86
Cdd:cd02683    1 SLELAAKEVLKRAVELDQEGRFQEALVCYQEGIDLLMQVLKGTKDEAKKKNLRQKISEYMDRAEAIKKRLDQEKEDG 77
 
Name Accession Description Interval E-value
MIT_C pfam16565
Phospholipase D-like domain at C-terminus of MIT; MIT_C is the C-terminal domain of ...
 100-198 3.06e-53

Phospholipase D-like domain at C-terminus of MIT; MIT_C is the C-terminal domain of MIT-containing proteins, pfam04212. It contains an unanticipated phospholipase d fold (PLD fold) that binds avidly to phosphoinositide-containing membranes. It is conserved in eukaryotes, though not fungi and plants, and some bacteria.


Pssm-ID: 465180  Cd Length: 137  Bit Score: 166.93  E-value: 3.06e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672064919  100 GFSYESLFREYLQETVTEVWIEDPYIRQTHQLYNFLRFCEMLIKKPCKVRTIHLLTSGDEGFGnTQQSSGLEEIKQSLRS 179
Cdd:pfam16565   1 GYSYESLFGPYLDGTATEITIEDPYIRAPHQIRNLVRFCELLVKKCGNLKKIHLLTGEDEENL-DQQLDNLEELKDSLAS 79

                          90
                  ....*....|....*....
gi 672064919  180 HGVVLEINYSSSIHDREIR 198
Cdd:pfam16565  80 RGVTLTVEFSSTLHDREIR 98
MIT_C cd02685
MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and ...
 97-198 2.22e-51

MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown.


Pssm-ID: 239148  Cd Length: 148  Bit Score: 162.41  E-value: 2.22e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672064919  97 NATGFSYESLFREYLQETVTEVWIEDPYIRQTHQLYNFLRFCEMLIKKPCKVRTIHLLTSGDEGFGNtQQSSGLEEIKQS 176
Cdd:cd02685    1 NATGFSYDRLFGPYLDDGVTEITVEDPYIRNFHQIRNFLRFCELVVKPPCELKYIHLVTGEDEDNGK-QQIEALEEIKQS 79

                         90       100
                 ....*....|....*....|..
gi 672064919 177 LRSHGVVLEINYSSSIHDREIR 198
Cdd:cd02685   80 LASHGVEFTWEFSDTIHDREIR 101
MIT_1 cd02683
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 10-86 1.04e-39

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with unknown function, co-occuring with an as yet undescribed domain. The molecular function of the MIT domain is unclear.


Pssm-ID: 239146  Cd Length: 77  Bit Score: 130.24  E-value: 1.04e-39
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672064919  10 SDSTAAVAVLKRAVELDAESRYQQALVCYQEGIDMLLQVLKGTKESSKRSTLRTKISGYMDRAENIKKYLDQEKEDG 86
Cdd:cd02683    1 SLELAAKEVLKRAVELDQEGRFQEALVCYQEGIDLLMQVLKGTKDEAKKKNLRQKISEYMDRAEAIKKRLDQEKEDG 77
MIT pfam04212
MIT (microtubule interacting and transport) domain; The MIT domain forms an asymmetric ...
 14-77 1.66e-16

MIT (microtubule interacting and transport) domain; The MIT domain forms an asymmetric three-helix bundle and binds ESCRT-III (endosomal sorting complexes required for transport) substrates.


Pssm-ID: 461228  Cd Length: 66  Bit Score: 70.65  E-value: 1.66e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672064919   14 AAVAVLKRAVELDAESRYQQALVCYQEGIDMLLQVLKGTKESSKRSTLRTKISGYMDRAENIKK 77
Cdd:pfam04212   3 KALELVKKAVEEDNAGNYEEALELYKEALDYLLLALKETKNEERRELLRAKIAEYLERAEELKE 66
MIT smart00745
Microtubule Interacting and Trafficking molecule domain;
8-81 4.20e-15

Microtubule Interacting and Trafficking molecule domain;


Pssm-ID: 197854  Cd Length: 77  Bit Score: 67.33  E-value: 4.20e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672064919     8 QDSDSTAAVAVLKRAVELDAESRYQQALVCYQEGIDMLLQVLKGTKESSKRSTLRTKISGYMDRAENIKKYLDQ 81
Cdd:smart00745   1 TRDYLSKAKELISKALKADEAGNYEEALELYKKAIEYLLEGIKVESDSKRREALKAKAAEYLDRAEEIKKSLLE 74
 
Name Accession Description Interval E-value
MIT_C pfam16565
Phospholipase D-like domain at C-terminus of MIT; MIT_C is the C-terminal domain of ...
 100-198 3.06e-53

Phospholipase D-like domain at C-terminus of MIT; MIT_C is the C-terminal domain of MIT-containing proteins, pfam04212. It contains an unanticipated phospholipase d fold (PLD fold) that binds avidly to phosphoinositide-containing membranes. It is conserved in eukaryotes, though not fungi and plants, and some bacteria.


Pssm-ID: 465180  Cd Length: 137  Bit Score: 166.93  E-value: 3.06e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672064919  100 GFSYESLFREYLQETVTEVWIEDPYIRQTHQLYNFLRFCEMLIKKPCKVRTIHLLTSGDEGFGnTQQSSGLEEIKQSLRS 179
Cdd:pfam16565   1 GYSYESLFGPYLDGTATEITIEDPYIRAPHQIRNLVRFCELLVKKCGNLKKIHLLTGEDEENL-DQQLDNLEELKDSLAS 79

                          90
                  ....*....|....*....
gi 672064919  180 HGVVLEINYSSSIHDREIR 198
Cdd:pfam16565  80 RGVTLTVEFSSTLHDREIR 98
MIT_C cd02685
MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and ...
 97-198 2.22e-51

MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown.


Pssm-ID: 239148  Cd Length: 148  Bit Score: 162.41  E-value: 2.22e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672064919  97 NATGFSYESLFREYLQETVTEVWIEDPYIRQTHQLYNFLRFCEMLIKKPCKVRTIHLLTSGDEGFGNtQQSSGLEEIKQS 176
Cdd:cd02685    1 NATGFSYDRLFGPYLDDGVTEITVEDPYIRNFHQIRNFLRFCELVVKPPCELKYIHLVTGEDEDNGK-QQIEALEEIKQS 79

                         90       100
                 ....*....|....*....|..
gi 672064919 177 LRSHGVVLEINYSSSIHDREIR 198
Cdd:cd02685   80 LASHGVEFTWEFSDTIHDREIR 101
MIT_1 cd02683
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 10-86 1.04e-39

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with unknown function, co-occuring with an as yet undescribed domain. The molecular function of the MIT domain is unclear.


Pssm-ID: 239146  Cd Length: 77  Bit Score: 130.24  E-value: 1.04e-39
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672064919  10 SDSTAAVAVLKRAVELDAESRYQQALVCYQEGIDMLLQVLKGTKESSKRSTLRTKISGYMDRAENIKKYLDQEKEDG 86
Cdd:cd02683    1 SLELAAKEVLKRAVELDQEGRFQEALVCYQEGIDLLMQVLKGTKDEAKKKNLRQKISEYMDRAEAIKKRLDQEKEDG 77
MIT cd02656
MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain ...
 10-83 6.62e-21

MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar sorting proteins and others. The molecular function of the MIT domain is unclear.


Pssm-ID: 239121  Cd Length: 75  Bit Score: 82.36  E-value: 6.62e-21
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672064919  10 SDSTAAVAVLKRAVELDAESRYQQALVCYQEGIDMLLQVLKGTKESSKRSTLRTKISGYMDRAENIKKYLDQEK 83
Cdd:cd02656    1 ELLQQAKELIKQAVKEDEDGNYEEALELYKEALDYLLQALKAEKEPKLRKLLRKKVKEYLDRAEFLKELLKKQK 74
MIT pfam04212
MIT (microtubule interacting and transport) domain; The MIT domain forms an asymmetric ...
 14-77 1.66e-16

MIT (microtubule interacting and transport) domain; The MIT domain forms an asymmetric three-helix bundle and binds ESCRT-III (endosomal sorting complexes required for transport) substrates.


Pssm-ID: 461228  Cd Length: 66  Bit Score: 70.65  E-value: 1.66e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672064919   14 AAVAVLKRAVELDAESRYQQALVCYQEGIDMLLQVLKGTKESSKRSTLRTKISGYMDRAENIKK 77
Cdd:pfam04212   3 KALELVKKAVEEDNAGNYEEALELYKEALDYLLLALKETKNEERRELLRAKIAEYLERAEELKE 66
MIT smart00745
Microtubule Interacting and Trafficking molecule domain;
8-81 4.20e-15

Microtubule Interacting and Trafficking molecule domain;


Pssm-ID: 197854  Cd Length: 77  Bit Score: 67.33  E-value: 4.20e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672064919     8 QDSDSTAAVAVLKRAVELDAESRYQQALVCYQEGIDMLLQVLKGTKESSKRSTLRTKISGYMDRAENIKKYLDQ 81
Cdd:smart00745   1 TRDYLSKAKELISKALKADEAGNYEEALELYKKAIEYLLEGIKVESDSKRREALKAKAAEYLDRAEEIKKSLLE 74
MIT_VPS4 cd02678
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 15-83 7.10e-13

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in intracellular protein transport proteins of the AAA-ATPase family. The molecular function of the MIT domain is unclear.


Pssm-ID: 239141  Cd Length: 75  Bit Score: 61.13  E-value: 7.10e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 672064919  15 AVAVLKRAVELDAESRYQQALVCYQEGIDMLLQVLKGTKESSKRSTLRTKISGYMDRAENIKKYLDQEK 83
Cdd:cd02678    6 AIELVKKAIEEDNAGNYEEALRLYQHALEYFMHALKYEKNPKSKESIRAKCTEYLDRAEKLKEYLAKKE 74
MIT_SNX15 cd02677
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT ...
 15-75 5.99e-06

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.


Pssm-ID: 239140  Cd Length: 75  Bit Score: 42.72  E-value: 5.99e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672064919  15 AVAVLKRAVELDAESRYQQALVCYQEGIDMLLQVLKGTKESSKRSTLRTKISGYMDRAENI 75
Cdd:cd02677    6 AAELIRLALEKEEEGDYEAAFEFYRAGVDLLLKGVQGDSSPERREAVKRKIAEYLKRAEEI 66
MIT_2 cd02684
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 15-79 7.20e-05

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with an n-terminal serine/threonine kinase domain. The molecular function of the MIT domain is unclear.


Pssm-ID: 239147  Cd Length: 75  Bit Score: 39.80  E-value: 7.20e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 672064919  15 AVAVLKRAVELDAESRYQQALVCYQEGIDMLLQVLKGTKESSKRSTLRTKISGYMDRAENIKKYL 79
Cdd:cd02684    6 AIALVVQAVKKDQRGDAAAALSLYCSALQYFVPALHYETDAQRKEALRQKVLQYVSRAEELKALI 70
MIT_calpain7_1 cd02681
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 15-73 7.70e-03

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in the nuclear thiol protease PalBH. The molecular function of the MIT domain is unclear.


Pssm-ID: 239144  Cd Length: 76  Bit Score: 34.11  E-value: 7.70e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 672064919  15 AVAVLKRAVELDAESRYQQALVCYQEGIDMLLQV-LKGTKESSKRSTLRTKISGYMDRAE 73
Cdd:cd02681    6 AVQFARLAVQRDQEGRYSEAVFYYKEAAQLLIYAeMAGTLNDSHLKTIQEKSNEYLDRAQ 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH