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Conserved domains on  [gi|672086262|ref|XP_008771116|]
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cell division cycle and apoptosis regulator protein 1 isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DBC1 pfam14443
DBC1; DBC1 and it homologs from diverse eukaryotes are a catalytically inactive version of the ...
 476-601 4.33e-64

DBC1; DBC1 and it homologs from diverse eukaryotes are a catalytically inactive version of the Nudix hydrolase (MutT) domain. DBC1 is predicted to bind NAD metabolites and regulate the activity of SIRT1 or related deacetylases by sensing the soluble products or substrates of the NAD-dependent deacetylation reaction.


:

Pssm-ID: 464175  Cd Length: 123  Bit Score: 212.59  E-value: 4.33e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672086262   476 QHPARLVKFLVGMKGKD-EAMAIGGHWSPSLDGPNPEKDPSVLIKTAIRCCKALTGIDLSVCTQWYRFAEIRYHRpeetH 554
Cdd:pfam14443    1 VHPCKLLKFLVGDRGKDnEIMAIGGPWSPSLDGADPTTDPSVLIRTAIRTTKALTGIDLSNCTQWYRFAEVHYYR----P 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 672086262   555 KGRTVPAHVETVVLFFPDVWHCLPTRSEWETLSRGYKQQLVEKLQGE 601
Cdd:pfam14443   77 KTDGFPSRQEITVIFLPDVSSCLPSLEEWESLWLQYRKALLEKEREA 123
S1-like pfam14444
S1-like; S1-like RNA binding domain found in DBC1
 145-201 1.41e-35

S1-like; S1-like RNA binding domain found in DBC1


:

Pssm-ID: 464176  Cd Length: 58  Bit Score: 129.03  E-value: 1.41e-35
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 672086262   145 RVFTGVVTKLHDTFGFVDEDVFFQLGAVKGKTPQVGDRVLVEATYNPNMPFKWNAQR 201
Cdd:pfam14444    2 RVFTGVVTKLQDYFGFVDEDVFFQLSVVKGRLPQVGDRVLVEAVYNPNMPFKWNAQR 58
LAIKA pfam19256
LAIKA domain; This presumed domain is found exclusively in the CCAR1 protein.
 720-787 2.21e-33

LAIKA domain; This presumed domain is found exclusively in the CCAR1 protein.


:

Pssm-ID: 466012 [Multi-domain]  Cd Length: 68  Bit Score: 123.12  E-value: 2.21e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672086262   720 LPDEPAIIVHPNWAAKSGKFDCSIMSLSVLLDYRLEDNKEHSFEVSLFAELFNEMLQRDFGVRIYKSL 787
Cdd:pfam19256    1 LPAEPAILVRPNRLAKGGKFDCKSLSLDGLLDYREDDTKESTFEVSLFAELFHEMLQRDFGFTIYKAL 68
BURAN pfam19257
BURAN domain; This presumed domain is found exclusively in the CCAR1 protein.
 369-451 3.38e-29

BURAN domain; This presumed domain is found exclusively in the CCAR1 protein.


:

Pssm-ID: 466013  Cd Length: 82  Bit Score: 111.64  E-value: 3.38e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672086262   369 DCPSCDMMELRRRYQNLYIPSDFFDAQFTWVDAFPLSRPFQLGNYCNFYVMHREVESLEKNVAVLDPPDADhLYSAKVML 448
Cdd:pfam19257    1 DSVERDYLELRKRYPRLYIPSDFSKLVLCWVETFPPLSPLPLDTPVSFHVMEKEVEPPLEQPAEAALEPAD-RYNAKVML 79


                   ...
gi 672086262   449 MAS 451
Cdd:pfam19257   80 LSG 82
SAP pfam02037
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding ...
 634-667 4.08e-07

SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.


:

Pssm-ID: 460424 [Multi-domain]  Cd Length: 35  Bit Score: 47.40  E-value: 4.08e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 672086262   634 KAMKVNDLRKELESRALSSKGLKSQLIARLTKQL 667
Cdd:pfam02037    2 SKLTVAELKEELRKRGLPTSGKKAELIERLQEYL 35
PRK10927 super family cl35972
cell division protein FtsN;
184-303 6.51e-05

cell division protein FtsN;


The actual alignment was detected with superfamily member PRK10927:

Pssm-ID: 236797 [Multi-domain]  Cd Length: 319  Bit Score: 46.60  E-value: 6.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672086262  184 LVEATYNPNMPfkwnAQRIQTLPNQNQ----SQTQPLLKTPTAVIQPIVPQTTFGVQAQPQPQSLLQAQISAASitpllq 259
Cdd:PRK10927  136 LVEVPWNEQTP----EQRQQTLQRQRQaqqlAEQQRLAQQSRTTEQSWQQQTRTSQAAPVQAQPRQSKPASTQQ------ 205

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 672086262  260 tqpqpllqqpqQKAGLLQPPVRIVSQPQP------ARRLDPPSRFSGRND 303
Cdd:PRK10927  206 -----------PYQDLLQTPAHTTAQSKPqqaapvTRAADAPKPTAEKKD 244
HMMR_N super family cl25727
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 1048-1153 1.50e-03

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


The actual alignment was detected with superfamily member pfam15905:

Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 42.11  E-value: 1.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672086262  1048 LEKSEKVRAEVEQKLQLLEEKTDEDGKTILNLENSNKSLSGELREV---KKDLGQLQENLKVSENMNLQFENQLNKTLRN 1124
Cdd:pfam15905  193 LEHSKGKVAQLEEKLVSTEKEKIEEKSETEKLLEYITELSCVSEQVekyKLDIAQLEELLKEKNDEIESLKQSLEEKEQE 272

                           90       100       110
                   ....*....|....*....|....*....|....
gi 672086262  1125 LSTVMDDIHTVLK-----KDNVKNEDRDQKSKEN 1153
Cdd:pfam15905  273 LSKQIKDLNEKCKlleseKEELLREYEEKEQTLN 306
EF-hand_7 pfam13499
EF-hand domain pair;
930-992 8.92e-03

EF-hand domain pair;


:

Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 36.08  E-value: 8.92e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 672086262   930 DLLMAFVYFDQSHCGYLLEKDLEEILYTL--GLHLSRAQVKKLLNKVvlrescfyrkltDTSKDG 992
Cdd:pfam13499    3 KLKEAFKLLDSDGDGYLDVEELKKLLRKLeeGEPLSDEEVEELFKEF------------DLDKDG 55
 
Name Accession Description Interval E-value
DBC1 pfam14443
DBC1; DBC1 and it homologs from diverse eukaryotes are a catalytically inactive version of the ...
 476-601 4.33e-64

DBC1; DBC1 and it homologs from diverse eukaryotes are a catalytically inactive version of the Nudix hydrolase (MutT) domain. DBC1 is predicted to bind NAD metabolites and regulate the activity of SIRT1 or related deacetylases by sensing the soluble products or substrates of the NAD-dependent deacetylation reaction.


Pssm-ID: 464175  Cd Length: 123  Bit Score: 212.59  E-value: 4.33e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672086262   476 QHPARLVKFLVGMKGKD-EAMAIGGHWSPSLDGPNPEKDPSVLIKTAIRCCKALTGIDLSVCTQWYRFAEIRYHRpeetH 554
Cdd:pfam14443    1 VHPCKLLKFLVGDRGKDnEIMAIGGPWSPSLDGADPTTDPSVLIRTAIRTTKALTGIDLSNCTQWYRFAEVHYYR----P 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 672086262   555 KGRTVPAHVETVVLFFPDVWHCLPTRSEWETLSRGYKQQLVEKLQGE 601
Cdd:pfam14443   77 KTDGFPSRQEITVIFLPDVSSCLPSLEEWESLWLQYRKALLEKEREA 123
S1-like pfam14444
S1-like; S1-like RNA binding domain found in DBC1
 145-201 1.41e-35

S1-like; S1-like RNA binding domain found in DBC1


Pssm-ID: 464176  Cd Length: 58  Bit Score: 129.03  E-value: 1.41e-35
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 672086262   145 RVFTGVVTKLHDTFGFVDEDVFFQLGAVKGKTPQVGDRVLVEATYNPNMPFKWNAQR 201
Cdd:pfam14444    2 RVFTGVVTKLQDYFGFVDEDVFFQLSVVKGRLPQVGDRVLVEAVYNPNMPFKWNAQR 58
LAIKA pfam19256
LAIKA domain; This presumed domain is found exclusively in the CCAR1 protein.
 720-787 2.21e-33

LAIKA domain; This presumed domain is found exclusively in the CCAR1 protein.


Pssm-ID: 466012 [Multi-domain]  Cd Length: 68  Bit Score: 123.12  E-value: 2.21e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672086262   720 LPDEPAIIVHPNWAAKSGKFDCSIMSLSVLLDYRLEDNKEHSFEVSLFAELFNEMLQRDFGVRIYKSL 787
Cdd:pfam19256    1 LPAEPAILVRPNRLAKGGKFDCKSLSLDGLLDYREDDTKESTFEVSLFAELFHEMLQRDFGFTIYKAL 68
BURAN pfam19257
BURAN domain; This presumed domain is found exclusively in the CCAR1 protein.
 369-451 3.38e-29

BURAN domain; This presumed domain is found exclusively in the CCAR1 protein.


Pssm-ID: 466013  Cd Length: 82  Bit Score: 111.64  E-value: 3.38e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672086262   369 DCPSCDMMELRRRYQNLYIPSDFFDAQFTWVDAFPLSRPFQLGNYCNFYVMHREVESLEKNVAVLDPPDADhLYSAKVML 448
Cdd:pfam19257    1 DSVERDYLELRKRYPRLYIPSDFSKLVLCWVETFPPLSPLPLDTPVSFHVMEKEVEPPLEQPAEAALEPAD-RYNAKVML 79


                   ...
gi 672086262   449 MAS 451
Cdd:pfam19257   80 LSG 82
SAP pfam02037
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding ...
 634-667 4.08e-07

SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.


Pssm-ID: 460424 [Multi-domain]  Cd Length: 35  Bit Score: 47.40  E-value: 4.08e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 672086262   634 KAMKVNDLRKELESRALSSKGLKSQLIARLTKQL 667
Cdd:pfam02037    2 SKLTVAELKEELRKRGLPTSGKKAELIERLQEYL 35
SAP smart00513
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;
634-667 5.01e-07

Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;


Pssm-ID: 128789 [Multi-domain]  Cd Length: 35  Bit Score: 47.10  E-value: 5.01e-07
                            10        20        30
                    ....*....|....*....|....*....|....
gi 672086262    634 KAMKVNDLRKELESRALSSKGLKSQLIARLTKQL 667
Cdd:smart00513    2 AKLKVSELKDELKKRGLSTSGTKAELVDRLLEAL 35
PRK10927 PRK10927
cell division protein FtsN;
184-303 6.51e-05

cell division protein FtsN;


Pssm-ID: 236797 [Multi-domain]  Cd Length: 319  Bit Score: 46.60  E-value: 6.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672086262  184 LVEATYNPNMPfkwnAQRIQTLPNQNQ----SQTQPLLKTPTAVIQPIVPQTTFGVQAQPQPQSLLQAQISAASitpllq 259
Cdd:PRK10927  136 LVEVPWNEQTP----EQRQQTLQRQRQaqqlAEQQRLAQQSRTTEQSWQQQTRTSQAAPVQAQPRQSKPASTQQ------ 205

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 672086262  260 tqpqpllqqpqQKAGLLQPPVRIVSQPQP------ARRLDPPSRFSGRND 303
Cdd:PRK10927  206 -----------PYQDLLQTPAHTTAQSKPqqaapvTRAADAPKPTAEKKD 244
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 1048-1153 1.50e-03

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 42.11  E-value: 1.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672086262  1048 LEKSEKVRAEVEQKLQLLEEKTDEDGKTILNLENSNKSLSGELREV---KKDLGQLQENLKVSENMNLQFENQLNKTLRN 1124
Cdd:pfam15905  193 LEHSKGKVAQLEEKLVSTEKEKIEEKSETEKLLEYITELSCVSEQVekyKLDIAQLEELLKEKNDEIESLKQSLEEKEQE 272

                           90       100       110
                   ....*....|....*....|....*....|....
gi 672086262  1125 LSTVMDDIHTVLK-----KDNVKNEDRDQKSKEN 1153
Cdd:pfam15905  273 LSKQIKDLNEKCKlleseKEELLREYEEKEQTLN 306
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1045-1152 4.55e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 41.16  E-value: 4.55e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672086262  1045 LQKLEKS-EKVRAEVEQKLQLLEEKTDEdgktILNLENSNKSLSGELREVKKDLGQLQENLKVSENMNLQFENQlnktLR 1123
Cdd:TIGR04523  470 LKVLSRSiNKIKQNLEQKQKELKSKEKE----LKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESK----IS 541

                           90       100
                   ....*....|....*....|....*....
gi 672086262  1124 NLSTVMDDIHTVLKKDNVKNEdRDQKSKE 1152
Cdd:TIGR04523  542 DLEDELNKDDFELKKENLEKE-IDEKNKE 569
EF-hand_7 pfam13499
EF-hand domain pair;
930-992 8.92e-03

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 36.08  E-value: 8.92e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 672086262   930 DLLMAFVYFDQSHCGYLLEKDLEEILYTL--GLHLSRAQVKKLLNKVvlrescfyrkltDTSKDG 992
Cdd:pfam13499    3 KLKEAFKLLDSDGDGYLDVEELKKLLRKLeeGEPLSDEEVEELFKEF------------DLDKDG 55
 
Name Accession Description Interval E-value
DBC1 pfam14443
DBC1; DBC1 and it homologs from diverse eukaryotes are a catalytically inactive version of the ...
 476-601 4.33e-64

DBC1; DBC1 and it homologs from diverse eukaryotes are a catalytically inactive version of the Nudix hydrolase (MutT) domain. DBC1 is predicted to bind NAD metabolites and regulate the activity of SIRT1 or related deacetylases by sensing the soluble products or substrates of the NAD-dependent deacetylation reaction.


Pssm-ID: 464175  Cd Length: 123  Bit Score: 212.59  E-value: 4.33e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672086262   476 QHPARLVKFLVGMKGKD-EAMAIGGHWSPSLDGPNPEKDPSVLIKTAIRCCKALTGIDLSVCTQWYRFAEIRYHRpeetH 554
Cdd:pfam14443    1 VHPCKLLKFLVGDRGKDnEIMAIGGPWSPSLDGADPTTDPSVLIRTAIRTTKALTGIDLSNCTQWYRFAEVHYYR----P 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 672086262   555 KGRTVPAHVETVVLFFPDVWHCLPTRSEWETLSRGYKQQLVEKLQGE 601
Cdd:pfam14443   77 KTDGFPSRQEITVIFLPDVSSCLPSLEEWESLWLQYRKALLEKEREA 123
S1-like pfam14444
S1-like; S1-like RNA binding domain found in DBC1
 145-201 1.41e-35

S1-like; S1-like RNA binding domain found in DBC1


Pssm-ID: 464176  Cd Length: 58  Bit Score: 129.03  E-value: 1.41e-35
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 672086262   145 RVFTGVVTKLHDTFGFVDEDVFFQLGAVKGKTPQVGDRVLVEATYNPNMPFKWNAQR 201
Cdd:pfam14444    2 RVFTGVVTKLQDYFGFVDEDVFFQLSVVKGRLPQVGDRVLVEAVYNPNMPFKWNAQR 58
LAIKA pfam19256
LAIKA domain; This presumed domain is found exclusively in the CCAR1 protein.
 720-787 2.21e-33

LAIKA domain; This presumed domain is found exclusively in the CCAR1 protein.


Pssm-ID: 466012 [Multi-domain]  Cd Length: 68  Bit Score: 123.12  E-value: 2.21e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672086262   720 LPDEPAIIVHPNWAAKSGKFDCSIMSLSVLLDYRLEDNKEHSFEVSLFAELFNEMLQRDFGVRIYKSL 787
Cdd:pfam19256    1 LPAEPAILVRPNRLAKGGKFDCKSLSLDGLLDYREDDTKESTFEVSLFAELFHEMLQRDFGFTIYKAL 68
BURAN pfam19257
BURAN domain; This presumed domain is found exclusively in the CCAR1 protein.
 369-451 3.38e-29

BURAN domain; This presumed domain is found exclusively in the CCAR1 protein.


Pssm-ID: 466013  Cd Length: 82  Bit Score: 111.64  E-value: 3.38e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672086262   369 DCPSCDMMELRRRYQNLYIPSDFFDAQFTWVDAFPLSRPFQLGNYCNFYVMHREVESLEKNVAVLDPPDADhLYSAKVML 448
Cdd:pfam19257    1 DSVERDYLELRKRYPRLYIPSDFSKLVLCWVETFPPLSPLPLDTPVSFHVMEKEVEPPLEQPAEAALEPAD-RYNAKVML 79


                   ...
gi 672086262   449 MAS 451
Cdd:pfam19257   80 LSG 82
SAP pfam02037
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding ...
 634-667 4.08e-07

SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.


Pssm-ID: 460424 [Multi-domain]  Cd Length: 35  Bit Score: 47.40  E-value: 4.08e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 672086262   634 KAMKVNDLRKELESRALSSKGLKSQLIARLTKQL 667
Cdd:pfam02037    2 SKLTVAELKEELRKRGLPTSGKKAELIERLQEYL 35
SAP smart00513
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;
634-667 5.01e-07

Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;


Pssm-ID: 128789 [Multi-domain]  Cd Length: 35  Bit Score: 47.10  E-value: 5.01e-07
                            10        20        30
                    ....*....|....*....|....*....|....
gi 672086262    634 KAMKVNDLRKELESRALSSKGLKSQLIARLTKQL 667
Cdd:smart00513    2 AKLKVSELKDELKKRGLSTSGTKAELVDRLLEAL 35
PRK10927 PRK10927
cell division protein FtsN;
184-303 6.51e-05

cell division protein FtsN;


Pssm-ID: 236797 [Multi-domain]  Cd Length: 319  Bit Score: 46.60  E-value: 6.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672086262  184 LVEATYNPNMPfkwnAQRIQTLPNQNQ----SQTQPLLKTPTAVIQPIVPQTTFGVQAQPQPQSLLQAQISAASitpllq 259
Cdd:PRK10927  136 LVEVPWNEQTP----EQRQQTLQRQRQaqqlAEQQRLAQQSRTTEQSWQQQTRTSQAAPVQAQPRQSKPASTQQ------ 205

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 672086262  260 tqpqpllqqpqQKAGLLQPPVRIVSQPQP------ARRLDPPSRFSGRND 303
Cdd:PRK10927  206 -----------PYQDLLQTPAHTTAQSKPqqaapvTRAADAPKPTAEKKD 244
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 1048-1153 1.50e-03

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 42.11  E-value: 1.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672086262  1048 LEKSEKVRAEVEQKLQLLEEKTDEDGKTILNLENSNKSLSGELREV---KKDLGQLQENLKVSENMNLQFENQLNKTLRN 1124
Cdd:pfam15905  193 LEHSKGKVAQLEEKLVSTEKEKIEEKSETEKLLEYITELSCVSEQVekyKLDIAQLEELLKEKNDEIESLKQSLEEKEQE 272

                           90       100       110
                   ....*....|....*....|....*....|....
gi 672086262  1125 LSTVMDDIHTVLK-----KDNVKNEDRDQKSKEN 1153
Cdd:pfam15905  273 LSKQIKDLNEKCKlleseKEELLREYEEKEQTLN 306
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1045-1152 4.55e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 41.16  E-value: 4.55e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672086262  1045 LQKLEKS-EKVRAEVEQKLQLLEEKTDEdgktILNLENSNKSLSGELREVKKDLGQLQENLKVSENMNLQFENQlnktLR 1123
Cdd:TIGR04523  470 LKVLSRSiNKIKQNLEQKQKELKSKEKE----LKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESK----IS 541

                           90       100
                   ....*....|....*....|....*....
gi 672086262  1124 NLSTVMDDIHTVLKKDNVKNEdRDQKSKE 1152
Cdd:TIGR04523  542 DLEDELNKDDFELKKENLEKE-IDEKNKE 569
EF-hand_7 pfam13499
EF-hand domain pair;
930-992 8.92e-03

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 36.08  E-value: 8.92e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 672086262   930 DLLMAFVYFDQSHCGYLLEKDLEEILYTL--GLHLSRAQVKKLLNKVvlrescfyrkltDTSKDG 992
Cdd:pfam13499    3 KLKEAFKLLDSDGDGYLDVEELKKLLRKLeeGEPLSDEEVEELFKEF------------DLDKDG 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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