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Conserved domains on  [gi|688564914|ref|XP_009301633|]
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PHD finger protein 21A isoform X2 [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PHA03247 super family cl33720
large tegument protein UL36; Provisional
87-402 1.51e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.86  E-value: 1.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688564914   87 QTQTPLPAASLTTPQSSVTPVIASKtlplvlRAATPASPII-MTPAPTITVVTTLGNTLLASP--SCADPQKSPVNFQPV 163
Cdd:PHA03247 2704 PPPTPEPAPHALVSATPLPPGPAAA------RQASPALPAApAPPAVPAGPATPGGPARPARPptTAGPPAPAPPAAPAA 2777
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688564914  164 IQSSNQGAEPVRVISNSTVVVQAASQPIKVPQFVPPTRQTTRPAALPQVRPKPPVSLTPVAGQVSVQTLQSPVLLSTALP 243
Cdd:PHA03247 2778 GPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVA 2857
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688564914  244 SSGHVQQMrilnglPSPNNTSILISPSTHIQA--------SAQTHTHQLPHNSPSSDNTIPAVEYGTEPktsllisPDTP 315
Cdd:PHA03247 2858 PGGDVRRR------PPSRSPAAKPAAPARPPVrrlarpavSRSTESFALPPDQPERPPQPQAPPPPQPQ-------PQPP 2924
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688564914  316 THTSPPLSLETPSSPASTNTHTPSSKHQDSPLKMAFMLSLGLVTRDYLEEIQSR-RQERKRRTTANPIysgamfEPERKK 394
Cdd:PHA03247 2925 PPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRvPQPAPSREAPASS------TPPLTG 2998

                  ....*...
gi 688564914  395 SSVSYLSS 402
Cdd:PHA03247 2999 HSLSRVSS 3006
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
87-402 1.51e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.86  E-value: 1.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688564914   87 QTQTPLPAASLTTPQSSVTPVIASKtlplvlRAATPASPII-MTPAPTITVVTTLGNTLLASP--SCADPQKSPVNFQPV 163
Cdd:PHA03247 2704 PPPTPEPAPHALVSATPLPPGPAAA------RQASPALPAApAPPAVPAGPATPGGPARPARPptTAGPPAPAPPAAPAA 2777
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688564914  164 IQSSNQGAEPVRVISNSTVVVQAASQPIKVPQFVPPTRQTTRPAALPQVRPKPPVSLTPVAGQVSVQTLQSPVLLSTALP 243
Cdd:PHA03247 2778 GPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVA 2857
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688564914  244 SSGHVQQMrilnglPSPNNTSILISPSTHIQA--------SAQTHTHQLPHNSPSSDNTIPAVEYGTEPktsllisPDTP 315
Cdd:PHA03247 2858 PGGDVRRR------PPSRSPAAKPAAPARPPVrrlarpavSRSTESFALPPDQPERPPQPQAPPPPQPQ-------PQPP 2924
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688564914  316 THTSPPLSLETPSSPASTNTHTPSSKHQDSPLKMAFMLSLGLVTRDYLEEIQSR-RQERKRRTTANPIysgamfEPERKK 394
Cdd:PHA03247 2925 PPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRvPQPAPSREAPASS------TPPLTG 2998

                  ....*...
gi 688564914  395 SSVSYLSS 402
Cdd:PHA03247 2999 HSLSRVSS 3006
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
87-340 7.83e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 49.38  E-value: 7.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688564914   87 QTQTPLPAASLTTPQSSVTPVIASKTLPL--VLRAATPASPIIMTPAPTITVVTTLGNTLLASPSCADP-QKSPVNFQPV 163
Cdd:pfam03154 250 QPMTQPPPPSQVSPQPLPQPSLHGQMPPMphSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPgQSQQRIHTPP 329
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688564914  164 IQSSNQGAEPVRVisnstvvVQAASQPIKVPQFVPPTRQTTRPAALPQVRPKPPVSLTPVAGQVSVQTLQSPVL-----L 238
Cdd:pfam03154 330 SQSQLQSQQPPRE-------QPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPPPPALkplssL 402
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688564914  239 STALPSSGH---VQQMRILNGLPSPNNTSILISPSTHIQASAQTH-----THQLPHNSPssdntipaveYGTEPktsllI 310
Cdd:pfam03154 403 STHHPPSAHpppLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHpptsgLHQVPSQSP----------FPQHP-----F 467
                         250       260       270
                  ....*....|....*....|....*....|
gi 688564914  311 SPDTPTHTSPPLSLETPSSPASTNTHTPSS 340
Cdd:pfam03154 468 VPGGPPPITPPSGPPTSTSSAMPGIQPPSS 497
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
87-402 1.51e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.86  E-value: 1.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688564914   87 QTQTPLPAASLTTPQSSVTPVIASKtlplvlRAATPASPII-MTPAPTITVVTTLGNTLLASP--SCADPQKSPVNFQPV 163
Cdd:PHA03247 2704 PPPTPEPAPHALVSATPLPPGPAAA------RQASPALPAApAPPAVPAGPATPGGPARPARPptTAGPPAPAPPAAPAA 2777
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688564914  164 IQSSNQGAEPVRVISNSTVVVQAASQPIKVPQFVPPTRQTTRPAALPQVRPKPPVSLTPVAGQVSVQTLQSPVLLSTALP 243
Cdd:PHA03247 2778 GPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVA 2857
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688564914  244 SSGHVQQMrilnglPSPNNTSILISPSTHIQA--------SAQTHTHQLPHNSPSSDNTIPAVEYGTEPktsllisPDTP 315
Cdd:PHA03247 2858 PGGDVRRR------PPSRSPAAKPAAPARPPVrrlarpavSRSTESFALPPDQPERPPQPQAPPPPQPQ-------PQPP 2924
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688564914  316 THTSPPLSLETPSSPASTNTHTPSSKHQDSPLKMAFMLSLGLVTRDYLEEIQSR-RQERKRRTTANPIysgamfEPERKK 394
Cdd:PHA03247 2925 PPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRvPQPAPSREAPASS------TPPLTG 2998

                  ....*...
gi 688564914  395 SSVSYLSS 402
Cdd:PHA03247 2999 HSLSRVSS 3006
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
87-340 7.83e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 49.38  E-value: 7.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688564914   87 QTQTPLPAASLTTPQSSVTPVIASKTLPL--VLRAATPASPIIMTPAPTITVVTTLGNTLLASPSCADP-QKSPVNFQPV 163
Cdd:pfam03154 250 QPMTQPPPPSQVSPQPLPQPSLHGQMPPMphSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPgQSQQRIHTPP 329
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688564914  164 IQSSNQGAEPVRVisnstvvVQAASQPIKVPQFVPPTRQTTRPAALPQVRPKPPVSLTPVAGQVSVQTLQSPVL-----L 238
Cdd:pfam03154 330 SQSQLQSQQPPRE-------QPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPPPPALkplssL 402
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688564914  239 STALPSSGH---VQQMRILNGLPSPNNTSILISPSTHIQASAQTH-----THQLPHNSPssdntipaveYGTEPktsllI 310
Cdd:pfam03154 403 STHHPPSAHpppLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHpptsgLHQVPSQSP----------FPQHP-----F 467
                         250       260       270
                  ....*....|....*....|....*....|
gi 688564914  311 SPDTPTHTSPPLSLETPSSPASTNTHTPSS 340
Cdd:pfam03154 468 VPGGPPPITPPSGPPTSTSSAMPGIQPPSS 497
PHA03247 PHA03247
large tegument protein UL36; Provisional
89-354 9.24e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 9.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688564914   89 QTPLPAASLTTPQSSVTPVIASKTLPLV--LRAATPASPIIMTPAPTITVVTTLGNTLLASPSCADPQKSPVNFQPVIQS 166
Cdd:PHA03247 2761 PTTAGPPAPAPPAAPAAGPPRRLTRPAVasLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP 2840
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688564914  167 SNQGAEPV----------------RVISNSTVVVQAASQPIKVPQFV-PPTRQTTRPAALPQVRPKPPVSLTPVAGQVSV 229
Cdd:PHA03247 2841 PPPGPPPPslplggsvapggdvrrRPPSRSPAAKPAAPARPPVRRLArPAVSRSTESFALPPDQPERPPQPQAPPPPQPQ 2920
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688564914  230 QTLQSPVLLSTALPSSGHVQ-----------QMRILNGLPSPNNTSILIS----PSTHIQASAQTHTHQLPHNSPSSDNT 294
Cdd:PHA03247 2921 PQPPPPPQPQPPPPPPPRPQpplapttdpagAGEPSGAVPQPWLGALVPGrvavPRFRVPQPAPSREAPASSTPPLTGHS 3000
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688564914  295 IPAV----------EYGTEPKTSLL-----------------------------ISPDTPTHTSPPLSLETPSSPASTNT 335
Cdd:PHA03247 3001 LSRVsswasslalhEETDPPPVSLKqtlwppddtedsdadslfdsdsersdleaLDPLPPEPHDPFAHEPDPATPEAGAR 3080
                         330
                  ....*....|....*....
gi 688564914  336 HTPSSKHQDSPLKMAFMLS 354
Cdd:PHA03247 3081 ESPSSQFGPPPLSANAALS 3099
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
75-351 4.44e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.60  E-value: 4.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688564914   75 QADGQTSTLLITQTQTPLPAASLTTPQSSVTPVIASKTLPLVLRAATPaSPIIMTPAPTITVVTTLGNTLLASPscADPQ 154
Cdd:pfam03154 220 QTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLP-QPSLHGQMPPMPHSLQTGPSHMQHP--VPPQ 296
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688564914  155 KSPVNFQPVIQSSNQGAEPVRVISNSTVVVQAASQPiKVPQFVPPTRQTTRPAALPQVRPKPPVSlTPVAGQVSVQTLQS 234
Cdd:pfam03154 297 PFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQS-QLQSQQPPREQPLPPAPLSMPHIKPPPT-TPIPQLPNPQSHKH 374
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688564914  235 PVLLSTalpssghvqqmrilnglPSPNNTSILISPSTHIQASAQTHTHQLPHNSPSSDNTIPAVEygtepktsllisPDT 314
Cdd:pfam03154 375 PPHLSG-----------------PSPFQMNSNLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQ------------QLP 425
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 688564914  315 PTHTSPPLSLETPSSPASTNTHTPSSKHQDSPLKMAF 351
Cdd:pfam03154 426 PPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPF 462
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
146-352 2.55e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.29  E-value: 2.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688564914  146 ASPSCADPQKSPVNFQPVIQSSNQGAEPVrvisnstvVVQAASQPIkvpqfVPPTRQTTRPAALPQvrPKPPVSLTPVAG 225
Cdd:pfam03154 144 TSPSIPSPQDNESDSDSSAQQQILQTQPP--------VLQAQSGAA-----SPPSPPPPGTTQAAT--AGPTPSAPSVPP 208
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688564914  226 QVSVQTLQSPVLLSTALPSSGHVQQMRILNG--LPSPNNT---------SILISPSTHIQASAQTHTHQLPH----NSPS 290
Cdd:pfam03154 209 QGSPATSQPPNQTQSTAAPHTLIQQTPTLHPqrLPSPHPPlqpmtqpppPSQVSPQPLPQPSLHGQMPPMPHslqtGPSH 288
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 688564914  291 SDNTIPAVEYGTEPKTSLLISPDTPTHTSPPLSLETPSSPASTNTHTPSSKHQDSPLKMAFM 352
Cdd:pfam03154 289 MQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPL 350
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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