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Conserved domains on  [gi|688575567|ref|XP_009303955|]
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myocyte-specific enhancer factor 2C isoform X4 [Danio rerio]

Protein Classification

myocyte-specific enhancer factor 2( domain architecture ID 10083624)

myocyte-specific enhancer factor 2 (MEF2) is a MADS (MCM1, AGAMOUS, DEFICIENS, and SRF, serum response factor) domain transcription factor, such as human MEF2C, a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes

CATH:  3.40.1810.10
Gene Ontology:  GO:0003700|GO:0046983
PubMed:  29802068|12949148
SCOP:  4001594

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MADS_MEF2_like cd00265
MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, ...
 1-67 3.02e-32

MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I subgroup mainly in position of the alpha helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


:

Pssm-ID: 238165 [Multi-domain]  Cd Length: 77  Bit Score: 117.65  E-value: 3.02e-32
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 688575567   1 MDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHES 67
Cdd:cd00265   11 ENSTNRQVTFSKRRNGLLKKAHELSVLCDAEVALIIFSSSGKLYEFSSPSMEKIIERYQKTSGSSLW 77
HJURP_C super family cl13744
Holliday junction regulator protein family C-terminal repeat; Although this family is ...
 87-143 9.41e-11

Holliday junction regulator protein family C-terminal repeat; Although this family is conserved in the Holliday junction regulator, HJURP, proteins in higher eukaryotes, alongside an Scm3, pfam10384, family, its exact function is not known. The C-terminal region of Scm3 proteins has been evolving rapidly, and this short repeat at the C-terminal end can be present in up to two copies in the higher eukaryotes.


The actual alignment was detected with superfamily member pfam12347:

Pssm-ID: 463543  Cd Length: 63  Bit Score: 57.36  E-value: 9.41e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 688575567   87 SPDIDAEDSGHSPESEDKYRKINEDIDLMISRQRLCA-IPQSNYDMPVSIPVSNPNSL 143
Cdd:pfam12347   6 VKAISRPRTELPGRGENRYREIKEEFDKLHQEYCLSSpKQPPNTKMPVSVAVSNYRAG 63
 
Name Accession Description Interval E-value
MADS_MEF2_like cd00265
MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, ...
 1-67 3.02e-32

MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I subgroup mainly in position of the alpha helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238165 [Multi-domain]  Cd Length: 77  Bit Score: 117.65  E-value: 3.02e-32
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 688575567   1 MDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHES 67
Cdd:cd00265   11 ENSTNRQVTFSKRRNGLLKKAHELSVLCDAEVALIIFSSSGKLYEFSSPSMEKIIERYQKTSGSSLW 77
MADS smart00432
MADS domain;
1-49 2.26e-25

MADS domain;


Pssm-ID: 197721 [Multi-domain]  Cd Length: 59  Bit Score: 98.01  E-value: 2.26e-25
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 688575567     1 MDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYAST 49
Cdd:smart00432  11 ENKTNRQVTFSKRRNGLFKKAHELSVLCDAEVALIVFSPTGKLYEFASP 59
SRF-TF pfam00319
SRF-type transcription factor (DNA-binding and dimerization domain);
2-46 2.67e-23

SRF-type transcription factor (DNA-binding and dimerization domain);


Pssm-ID: 459760 [Multi-domain]  Cd Length: 48  Bit Score: 92.11  E-value: 2.67e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 688575567    2 DERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQY 46
Cdd:pfam00319   4 NKRARQVTFSKRRKGLFKKASELSVLCGAEVAVIVFSPTGKLYTF 48
HJURP_C pfam12347
Holliday junction regulator protein family C-terminal repeat; Although this family is ...
 87-143 9.41e-11

Holliday junction regulator protein family C-terminal repeat; Although this family is conserved in the Holliday junction regulator, HJURP, proteins in higher eukaryotes, alongside an Scm3, pfam10384, family, its exact function is not known. The C-terminal region of Scm3 proteins has been evolving rapidly, and this short repeat at the C-terminal end can be present in up to two copies in the higher eukaryotes.


Pssm-ID: 463543  Cd Length: 63  Bit Score: 57.36  E-value: 9.41e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 688575567   87 SPDIDAEDSGHSPESEDKYRKINEDIDLMISRQRLCA-IPQSNYDMPVSIPVSNPNSL 143
Cdd:pfam12347   6 VKAISRPRTELPGRGENRYREIKEEFDKLHQEYCLSSpKQPPNTKMPVSVAVSNYRAG 63
ARG80 COG5068
Regulator of arginine metabolism and related MADS box-containing transcription factors ...
 2-55 1.06e-05

Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription];


Pssm-ID: 227400 [Multi-domain]  Cd Length: 412  Bit Score: 47.70  E-value: 1.06e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 688575567   2 DERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVL 55
Cdd:COG5068   93 NKTKRSVTFSKRKHGINKKAFELSVLTGTEVLLLVISENGLVHTFTTPKLESVV 146
 
Name Accession Description Interval E-value
MADS_MEF2_like cd00265
MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, ...
 1-67 3.02e-32

MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I subgroup mainly in position of the alpha helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238165 [Multi-domain]  Cd Length: 77  Bit Score: 117.65  E-value: 3.02e-32
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 688575567   1 MDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHES 67
Cdd:cd00265   11 ENSTNRQVTFSKRRNGLLKKAHELSVLCDAEVALIIFSSSGKLYEFSSPSMEKIIERYQKTSGSSLW 77
MADS smart00432
MADS domain;
1-49 2.26e-25

MADS domain;


Pssm-ID: 197721 [Multi-domain]  Cd Length: 59  Bit Score: 98.01  E-value: 2.26e-25
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 688575567     1 MDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYAST 49
Cdd:smart00432  11 ENKTNRQVTFSKRRNGLFKKAHELSVLCDAEVALIVFSPTGKLYEFASP 59
SRF-TF pfam00319
SRF-type transcription factor (DNA-binding and dimerization domain);
2-46 2.67e-23

SRF-type transcription factor (DNA-binding and dimerization domain);


Pssm-ID: 459760 [Multi-domain]  Cd Length: 48  Bit Score: 92.11  E-value: 2.67e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 688575567    2 DERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQY 46
Cdd:pfam00319   4 NKRARQVTFSKRRKGLFKKASELSVLCGAEVAVIVFSPTGKLYTF 48
MADS cd00120
MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic ...
 1-49 9.20e-23

MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ Type II. These subgroups differ mainly in position of the alpha 2 helix responsible for the dimerization interface; Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238067 [Multi-domain]  Cd Length: 59  Bit Score: 91.04  E-value: 9.20e-23
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 688575567   1 MDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYAST 49
Cdd:cd00120   11 ENKTSRQVTFSKRRNGLFKKASELSVLCDAEVAVIVFSPSGKLYEFWSS 59
MADS_SRF_like cd00266
SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) ...
 1-72 1.81e-20

SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in position of the alpha 2 helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238166 [Multi-domain]  Cd Length: 83  Bit Score: 85.39  E-value: 1.81e-20
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 688575567   1 MDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDM-DKVLLKYTEYNEPHESRTNSD 72
Cdd:cd00266   11 ENKKKRAVTFSKRRQGLFKKASELSTLCGAEVAVIVYSPSGKLYVFWPSSEvEGVISRFEVLSALERKKKAVD 83
HJURP_C pfam12347
Holliday junction regulator protein family C-terminal repeat; Although this family is ...
 87-143 9.41e-11

Holliday junction regulator protein family C-terminal repeat; Although this family is conserved in the Holliday junction regulator, HJURP, proteins in higher eukaryotes, alongside an Scm3, pfam10384, family, its exact function is not known. The C-terminal region of Scm3 proteins has been evolving rapidly, and this short repeat at the C-terminal end can be present in up to two copies in the higher eukaryotes.


Pssm-ID: 463543  Cd Length: 63  Bit Score: 57.36  E-value: 9.41e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 688575567   87 SPDIDAEDSGHSPESEDKYRKINEDIDLMISRQRLCA-IPQSNYDMPVSIPVSNPNSL 143
Cdd:pfam12347   6 VKAISRPRTELPGRGENRYREIKEEFDKLHQEYCLSSpKQPPNTKMPVSVAVSNYRAG 63
ARG80 COG5068
Regulator of arginine metabolism and related MADS box-containing transcription factors ...
 2-55 1.06e-05

Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription];


Pssm-ID: 227400 [Multi-domain]  Cd Length: 412  Bit Score: 47.70  E-value: 1.06e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 688575567   2 DERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVL 55
Cdd:COG5068   93 NKTKRSVTFSKRKHGINKKAFELSVLTGTEVLLLVISENGLVHTFTTPKLESVV 146
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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