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Conserved domains on  [gi|755514861|ref|XP_011239289|]
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speedy protein E4A isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Spy1 super family cl12893
Cell cycle regulatory protein; Speedy (Spy1) is a cell cycle regulatory protein which ...
 135-193 3.14e-37

Cell cycle regulatory protein; Speedy (Spy1) is a cell cycle regulatory protein which activates CDK2, the major kinase that allows progression through G1/S phase and further replication events. Spy1 expression overcomes a p27-induced cell cycle arrest to allow for DNA synthesis, so cell cycle progression occurs due to an interaction between Spy1 and p27. Spy1 is also known as Ringo protein A.


The actual alignment was detected with superfamily member pfam11357:

Pssm-ID: 463263  Cd Length: 131  Bit Score: 126.20  E-value: 3.14e-37
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 755514861  135 EHHKVFTKLLEDPVVKKFLTWDKMLRVSDKYLLSMVIAYFSRAGLFSWQYRPIHFFLAL 193
Cdd:pfam11357   1 EEMEAFFRLLEDPVIQDFLAWDKCLRVSDKYLLAMVFAYFKRAGLFSWEYTRINFFLAL 59
 
Name Accession Description Interval E-value
Spy1 pfam11357
Cell cycle regulatory protein; Speedy (Spy1) is a cell cycle regulatory protein which ...
 135-193 3.14e-37

Cell cycle regulatory protein; Speedy (Spy1) is a cell cycle regulatory protein which activates CDK2, the major kinase that allows progression through G1/S phase and further replication events. Spy1 expression overcomes a p27-induced cell cycle arrest to allow for DNA synthesis, so cell cycle progression occurs due to an interaction between Spy1 and p27. Spy1 is also known as Ringo protein A.


Pssm-ID: 463263  Cd Length: 131  Bit Score: 126.20  E-value: 3.14e-37
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 755514861  135 EHHKVFTKLLEDPVVKKFLTWDKMLRVSDKYLLSMVIAYFSRAGLFSWQYRPIHFFLAL 193
Cdd:pfam11357   1 EEMEAFFRLLEDPVIQDFLAWDKCLRVSDKYLLAMVFAYFKRAGLFSWEYTRINFFLAL 59
 
Name Accession Description Interval E-value
Spy1 pfam11357
Cell cycle regulatory protein; Speedy (Spy1) is a cell cycle regulatory protein which ...
 135-193 3.14e-37

Cell cycle regulatory protein; Speedy (Spy1) is a cell cycle regulatory protein which activates CDK2, the major kinase that allows progression through G1/S phase and further replication events. Spy1 expression overcomes a p27-induced cell cycle arrest to allow for DNA synthesis, so cell cycle progression occurs due to an interaction between Spy1 and p27. Spy1 is also known as Ringo protein A.


Pssm-ID: 463263  Cd Length: 131  Bit Score: 126.20  E-value: 3.14e-37
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 755514861  135 EHHKVFTKLLEDPVVKKFLTWDKMLRVSDKYLLSMVIAYFSRAGLFSWQYRPIHFFLAL 193
Cdd:pfam11357   1 EEMEAFFRLLEDPVIQDFLAWDKCLRVSDKYLLAMVFAYFKRAGLFSWEYTRINFFLAL 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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