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Conserved domains on  [gi|755525781|ref|XP_011240564|]
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chromaffin granule amine transporter isoform X3 [Mus musculus]

Protein Classification

amine MFS transporter( domain architecture ID 13024382)

amine major facilitator superfamily (MFS) transporter belonging to the solute carrier family 18 facilitates the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_SLC18A1_2_VAT1_2 cd17384
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ...
 34-424 0e+00

Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340942 [Multi-domain]  Cd Length: 373  Bit Score: 563.35  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  34 DNMLLTVVeehVPFrvawingtIPppvteagsvpknnclqgiEFLEEeNVRIGILFASKALMQLLVNPFVGPLTNRIGYH 113
Cdd:cd17384   12 DNMLLTVV---VPI--------IP------------------DYLNE-NVRVGLLFASKALVQLITNPIVGPLTNRIGYS 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 114 IPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASVYTDNYERGRAMGIALGGLALGLLVGAPFG 193
Cdd:cd17384   62 LPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVGSACSSVAGMGMLASLYPDDKERGKAMGIALGGLALGVLVGPPFG 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 194 SVMYEFVGKSSPFLILAFLALLDGALQFCILWPSKVSPESAMGTPLLTLLKDPYILVAAGSICLANMGVAILEPTLPIWM 273
Cdd:cd17384  142 GVMYEFVGKSAPFLILAFLALLDGALQLFILQPSVKSEESEEGTPWKTLLKDPYILIAAGAICFSNSGIAILEPCLPIWM 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 274 MQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVGMVAVGISLLCVPLAHNIFGLIGPNAGLGFAIGMVD 353
Cdd:cd17384  222 METMCPPKWQLGTAFLPDSIGYLIGTNLFGPLAHKIGRWLCSLLGMLLVGISLILIPLAKNIYGLIIPHFGLGLGIGMVD 301

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755525781 354 SSLMPIMGYLVDLRHTSVYGSVYAIADVAFCVGFAIGPSTGGVIVPVIGFPWLMVIIGTINIIYAPLCCFL 424
Cdd:cd17384  302 SSMMPLLAYLVDLRHSSVYGSVYAIADVAFCLAFALGPSLGGAIVKSIGFPWLMRIIGIINILYAPLLFFL 372
 
Name Accession Description Interval E-value
MFS_SLC18A1_2_VAT1_2 cd17384
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ...
 34-424 0e+00

Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340942 [Multi-domain]  Cd Length: 373  Bit Score: 563.35  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  34 DNMLLTVVeehVPFrvawingtIPppvteagsvpknnclqgiEFLEEeNVRIGILFASKALMQLLVNPFVGPLTNRIGYH 113
Cdd:cd17384   12 DNMLLTVV---VPI--------IP------------------DYLNE-NVRVGLLFASKALVQLITNPIVGPLTNRIGYS 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 114 IPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASVYTDNYERGRAMGIALGGLALGLLVGAPFG 193
Cdd:cd17384   62 LPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVGSACSSVAGMGMLASLYPDDKERGKAMGIALGGLALGVLVGPPFG 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 194 SVMYEFVGKSSPFLILAFLALLDGALQFCILWPSKVSPESAMGTPLLTLLKDPYILVAAGSICLANMGVAILEPTLPIWM 273
Cdd:cd17384  142 GVMYEFVGKSAPFLILAFLALLDGALQLFILQPSVKSEESEEGTPWKTLLKDPYILIAAGAICFSNSGIAILEPCLPIWM 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 274 MQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVGMVAVGISLLCVPLAHNIFGLIGPNAGLGFAIGMVD 353
Cdd:cd17384  222 METMCPPKWQLGTAFLPDSIGYLIGTNLFGPLAHKIGRWLCSLLGMLLVGISLILIPLAKNIYGLIIPHFGLGLGIGMVD 301

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755525781 354 SSLMPIMGYLVDLRHTSVYGSVYAIADVAFCVGFAIGPSTGGVIVPVIGFPWLMVIIGTINIIYAPLCCFL 424
Cdd:cd17384  302 SSMMPLLAYLVDLRHSSVYGSVYAIADVAFCLAFALGPSLGGAIVKSIGFPWLMRIIGIINILYAPLLFFL 372
2_A_01_02 TIGR00880
Multidrug resistance protein;
86-227 1.18e-29

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 112.74  E-value: 1.18e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781   86 GILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASVY 165
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755525781  166 TDNyERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLDGALQFCILWPS 227
Cdd:TIGR00880  81 PPE-ERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
85-386 4.68e-26

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 108.52  E-value: 4.68e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  85 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASV 164
Cdd:COG2814   47 AGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADL 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 165 YTDNyERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLDGALQFCILWPSKVSPESAMGTPLLTLLK 244
Cdd:COG2814  127 VPPE-RRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLR 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 245 DPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVGMVAVGI 324
Cdd:COG2814  206 RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLAL 285

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755525781 325 SLLCVPLAHNIFGLIGPNAGLGFAIGMVDSslmPIMGYLVDLRHTSVYGSVYAIADVAFCVG 386
Cdd:COG2814  286 GLLLLALAGSLWLLLLALFLLGFGFGLLFP---LLQALVAELAPPEARGRASGLYNSAFFLG 344
MFS_1 pfam07690
Major Facilitator Superfamily;
85-391 4.30e-18

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 85.16  E-value: 4.30e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781   85 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASV 164
Cdd:pfam07690  34 IGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADW 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  165 YTDNyERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLdGALQFCILWPSKVSPESAM--------G 236
Cdd:pfam07690 114 FPPE-ERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLL-AAVLLLLPRPPPESKRPKPaeearlslI 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  237 TPLLTLLKDPYILVAAGsICLANMGVAILEPTLPIWmMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSL 316
Cdd:pfam07690 192 VAWKALLRDPVLWLLLA-LLLFGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL 269

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755525781  317 VGMVAVGISLLCVPLAHNIFGLIGPNAGLgFAIGMVDSSLMP-IMGYLVDLRHTSVYGSVYAIADVAFCVGFAIGP 391
Cdd:pfam07690 270 LALLLLILAALGLLLLSLTLSSLWLLLAL-LLLGFGFGLVFPaLNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
emrD PRK11652
multidrug transporter EmrD;
102-149 1.82e-03

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 40.66  E-value: 1.82e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 755525781 102 FVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIG 149
Cdd:PRK11652  62 FYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLG 109
 
Name Accession Description Interval E-value
MFS_SLC18A1_2_VAT1_2 cd17384
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ...
 34-424 0e+00

Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340942 [Multi-domain]  Cd Length: 373  Bit Score: 563.35  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  34 DNMLLTVVeehVPFrvawingtIPppvteagsvpknnclqgiEFLEEeNVRIGILFASKALMQLLVNPFVGPLTNRIGYH 113
Cdd:cd17384   12 DNMLLTVV---VPI--------IP------------------DYLNE-NVRVGLLFASKALVQLITNPIVGPLTNRIGYS 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 114 IPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASVYTDNYERGRAMGIALGGLALGLLVGAPFG 193
Cdd:cd17384   62 LPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVGSACSSVAGMGMLASLYPDDKERGKAMGIALGGLALGVLVGPPFG 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 194 SVMYEFVGKSSPFLILAFLALLDGALQFCILWPSKVSPESAMGTPLLTLLKDPYILVAAGSICLANMGVAILEPTLPIWM 273
Cdd:cd17384  142 GVMYEFVGKSAPFLILAFLALLDGALQLFILQPSVKSEESEEGTPWKTLLKDPYILIAAGAICFSNSGIAILEPCLPIWM 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 274 MQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVGMVAVGISLLCVPLAHNIFGLIGPNAGLGFAIGMVD 353
Cdd:cd17384  222 METMCPPKWQLGTAFLPDSIGYLIGTNLFGPLAHKIGRWLCSLLGMLLVGISLILIPLAKNIYGLIIPHFGLGLGIGMVD 301

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755525781 354 SSLMPIMGYLVDLRHTSVYGSVYAIADVAFCVGFAIGPSTGGVIVPVIGFPWLMVIIGTINIIYAPLCCFL 424
Cdd:cd17384  302 SSMMPLLAYLVDLRHSSVYGSVYAIADVAFCLAFALGPSLGGAIVKSIGFPWLMRIIGIINILYAPLLFFL 372
MFS_SLC18A3_VAChT cd17383
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ...
 80-424 1.80e-113

Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340941 [Multi-domain]  Cd Length: 378  Bit Score: 338.90  E-value: 1.80e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  80 EENVRIGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLG 159
Cdd:cd17383   27 NEDIAIGVLFASKAIVQLLVNPFSGTLIDRVGYDIPMMIGLTVMFLSTAVFAFGESYAVLFFARSLQGVGSAFADTAGLA 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 160 MLASVYTDNYERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLDGALQFCILWP----SKVSPESAM 235
Cdd:cd17383  107 MIADRFTEEAERSKALGIALAFISFGCLVAPPFGGILYEFAGKEVPFLILAFVCLLDGLLLLLVMKPvrreTRANMPEPV 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 236 GTPLLTLLKDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGR--WL 313
Cdd:cd17383  187 GTPIHRLLMDPYIAVCAGALTMANVSLAFLEPTIANWMKDTMNASEWQMGLVWLPAFFPHVLGVYLTVKLAAKYPHyqWL 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 314 CSLVGMVAVGISLLCVPLAHNIFGLIGPNAGLGFAIGMVDSSLMPIMGYLVDLRHTSVYGSVYAIADVAFCVGFAIGPST 393
Cdd:cd17383  267 MAAVGLAIEGASCFIVPFCTNFGVLIIPLCGICFGIALVDTALLPTLGFLVDVRHVSVYGSVYAIADISYSLAYALGPIV 346

                        330       340       350
                 ....*....|....*....|....*....|.
gi 755525781 394 GGVIVPVIGFPWLMVIIGTINIIYAPLCCFL 424
Cdd:cd17383  347 AGQIVHSIGFTQLNIGIGLANLLYAPVLLLL 377
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 82-420 4.46e-61

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 203.58  E-value: 4.46e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  82 NVRIGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGML 161
Cdd:cd17325   30 VAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALI 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 162 ASVYTDNyERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLDGALQFCILWPSKVSPESA------M 235
Cdd:cd17325  110 ADIAPPE-ERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRavsaarL 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 236 GTPLLTLLKDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCS 315
Cdd:cd17325  189 RSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLI 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 316 LVGMVAVGISLLCVPLAHNIFGLIGPNAGLGFAIGMVDSSLMPIMGYLVDLRHtsvYGSVYAIADVAFCVGFAIGPSTGG 395
Cdd:cd17325  269 LIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEG---RGTAMGLFNTAFSLGMVLGPLLGG 345

                        330       340
                 ....*....|....*....|....*
gi 755525781 396 VIVPVIGFPWLMVIIGTINIIYAPL 420
Cdd:cd17325  346 FLYDAFGFATPFLAAAALLLLAAVL 370
2_A_01_02 TIGR00880
Multidrug resistance protein;
86-227 1.18e-29

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 112.74  E-value: 1.18e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781   86 GILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASVY 165
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755525781  166 TDNyERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLDGALQFCILWPS 227
Cdd:TIGR00880  81 PPE-ERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
85-386 4.68e-26

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 108.52  E-value: 4.68e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  85 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASV 164
Cdd:COG2814   47 AGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADL 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 165 YTDNyERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLDGALQFCILWPSKVSPESAMGTPLLTLLK 244
Cdd:COG2814  127 VPPE-RRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLR 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 245 DPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVGMVAVGI 324
Cdd:COG2814  206 RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLAL 285

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755525781 325 SLLCVPLAHNIFGLIGPNAGLGFAIGMVDSslmPIMGYLVDLRHTSVYGSVYAIADVAFCVG 386
Cdd:COG2814  286 GLLLLALAGSLWLLLLALFLLGFGFGLLFP---LLQALVAELAPPEARGRASGLYNSAFFLG 344
MFS_SLC18B1 cd17385
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ...
 85-416 1.33e-20

Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340943 [Multi-domain]  Cd Length: 390  Bit Score: 93.44  E-value: 1.33e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  85 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAF-----SGT--YALLFVARTLQGIGSSFSSVAG 157
Cdd:cd17385   36 IGLVFGCFALVIFLTSPIFGKYLVKIGAKFMFVAGMFVSGGCTILFGFldrvpDGTvfIALCFLVRIVEAVGFAAFITAS 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 158 LGMLASVYTDNYerGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLDGALQFCILwPSKVSPESAMGT 237
Cdd:cd17385  116 FAIIAKEFPNNI--ATVLGTLETFSGLGLMLGPPLGGFLYQAGGYELPFLVLGCLLLLTVPLNMFIL-PRYDDDPSPKSG 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 238 PLLTLLKDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPeWQLGLAFLPASVAYLIGTNLFGVLANKMG-RWLCSL 316
Cdd:cd17385  193 SMLKLLKIPSVLLLCLSIVSGSVSLGFLDPTLSPHLRQFKLSP-GQVGLMFLILAGSYAISAPLWGWLSDKKKiPKWLMV 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 317 VGMVAVGISLLCV---PLAH-------NIFGLIGpnagLGFAIGMvdsSLMPIMGYLVDLRHT-------SVYGSVYAIA 379
Cdd:cd17385  272 IGSIITGVGFLLLgpaPLLPikselwmVIIGLVL----LGLSLGA---ALVPTFPELLNCAREygfpdnlSTYGLVSGLF 344

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 755525781 380 DVAFCVGFAIGPSTGGVIVPVIGFPWLMVIIGTINII 416
Cdd:cd17385  345 NAAFSLGAFIGPTLGGFLLERLGFEWAATIQAGLAFV 381
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 85-416 5.14e-19

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 88.42  E-value: 5.14e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  85 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASv 164
Cdd:cd17489   33 AGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVAD- 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 165 YTDNYERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALldGALQFCILWP---SKVSPESAMGTPLLT 241
Cdd:cd17489  112 IIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLAL--LALLLVFLVKdppPVAAEEAEAGTRAFR 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 242 LLKDPYILVAAGSICLANMGVAILEPTLPIWMMQTmcsPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVGMVA 321
Cdd:cd17489  190 RLVEKKVLPPALILFLASIAYGAISTFLPLYAAER---GISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLL 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 322 VGISLLCVPLAHNIFGLIGpnAGLGFAIGMvdSSLMPIMGYL-VDLRHTSVYGSVYAIADVAFCVGFAIGPSTGGVIVPV 400
Cdd:cd17489  267 LALGLLLLSFAGSPWMLLL--AAVLYGLGF--GLLFPALQALaVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAEL 342

                        330
                 ....*....|....*.
gi 755525781 401 IGFPWLMVIIGTINII 416
Cdd:cd17489  343 FGYRAMFLLAAVVVLL 358
MFS_1 pfam07690
Major Facilitator Superfamily;
85-391 4.30e-18

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 85.16  E-value: 4.30e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781   85 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASV 164
Cdd:pfam07690  34 IGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADW 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  165 YTDNyERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLdGALQFCILWPSKVSPESAM--------G 236
Cdd:pfam07690 114 FPPE-ERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLL-AAVLLLLPRPPPESKRPKPaeearlslI 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  237 TPLLTLLKDPYILVAAGsICLANMGVAILEPTLPIWmMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSL 316
Cdd:pfam07690 192 VAWKALLRDPVLWLLLA-LLLFGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL 269

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755525781  317 VGMVAVGISLLCVPLAHNIFGLIGPNAGLgFAIGMVDSSLMP-IMGYLVDLRHTSVYGSVYAIADVAFCVGFAIGP 391
Cdd:pfam07690 270 LALLLLILAALGLLLLSLTLSSLWLLLAL-LLLGFGFGLVFPaLNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
82-430 1.31e-16

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 81.07  E-value: 1.31e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  82 NVRIGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGML 161
Cdd:COG2271   44 AAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLI 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 162 ASVYTDNyERGRAMGIALGGLALGLLVGAPFGSVMYEFVGksspflilaflalldgaLQFCILWPskvspesAMGTPLLT 241
Cdd:COG2271  124 AEWFPPK-ERGRALGIFNAGGPLGGALAPPLLGWLLAAFG-----------------WRAAFLIL-------GLPGLLLA 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 242 LLKdpyILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGR--WLCSLVGM 319
Cdd:COG2271  179 LLR---FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGL 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 320 VAVGISLLCVPLAHNIFGLIGPNAGLGFAIGMVdssLMPIMGYLVDLRHTSVYGSVYAIADVAFCVGFAIGPSTGGVIVP 399
Cdd:COG2271  256 LLAALALLLLALLPSPALAIALLFLAGFGLGGA---FGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLD 332

                        330       340       350
                 ....*....|....*....|....*....|.
gi 755525781 400 VIGFPWLMVIIGTINIIYAPLCCFLQNPPAK 430
Cdd:COG2271  333 ATGYQAAFLLLAALALLAALLALLLLRETRK 363
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 75-421 2.50e-15

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 77.47  E-value: 2.50e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  75 IEFLEEENVRIGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSS 154
Cdd:cd06174   23 LQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLID 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 155 VAGLGMLASVYTDNyERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLDGALQFCILWP-------- 226
Cdd:cd06174  103 PAVLALIADLFPER-ERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVpdppesar 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 227 --SKVSPESAMGTPLLTLLKDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGV 304
Cdd:cd06174  182 akNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGL 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 305 LANK-MGRWLCSLVGMVAVGISLLCVPLAHNIFGLIGPNAGLGFAIGMVdssLMPIMGYLVDLRHTSVYGSVYAIADVAF 383
Cdd:cd06174  262 LSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGL---LPLSFALIAELFPPEIRGTAFGLLNTFG 338

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 755525781 384 CVGFAIGPSTGGVIVP-VIGFPWLMVIIGTINIIYAPLC 421
Cdd:cd06174  339 FLGGAIGPLLAGFLLAaTFGLTGAFLVLAVLLLLAAILL 377
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 85-413 7.80e-15

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 75.66  E-value: 7.80e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  85 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASV 164
Cdd:cd17324   36 AGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 165 YTDNyERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLalldGALQFCILW------PSKVSPESAMGTP 238
Cdd:cd17324  116 VPPE-KRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVL----ALLAALLLWrllpslPPKKPGSLGLLSS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 239 LLTLLKDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVG 318
Cdd:cd17324  191 LLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIAL 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 319 MVAVGISLLCVPLAHNIFGLIGPNAGLGFAIGMVDSSLmpiMGYLVDL--RHTSVYGSVYAiadVAFCVGFAIGPSTGGV 396
Cdd:cd17324  271 LLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSAL---QTRVLRLapEARGLASSLYL---AAYNLGGALGAALGGL 344

                        330
                 ....*....|....*..
gi 755525781 397 IVPVIGFPWLMVIIGTI 413
Cdd:cd17324  345 VLDHGGWAGVGWVGAAL 361
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 85-420 2.91e-14

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 74.19  E-value: 2.91e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  85 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASV 164
Cdd:cd17329   37 VGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADV 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 165 YTD-NYERGRAMGIALGGLALGllvgapFGSVMYEFVGKSSPFLILAFLALLDGALQFCILW-------PSKVSPESAMG 236
Cdd:cd17329  117 TTPeNRTRAFSLLYWAINLGVA------IGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFllpetrpKRRAAEKTEIL 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 237 TPLLTLLKD-PYILVAAGSICLAnMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCS 315
Cdd:cd17329  191 RGYKIVLRDrAFLLFLLASFLIS-LIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKIL 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 316 LVGMVAVGISLLCVPLAHNIFGLIGPNAGLGFAIGMVDSSLMPIMGYLVDLRHTSVYGSVYAIadvAFCVGFAIGPSTGG 395
Cdd:cd17329  270 MIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYAL---AWGLGRAIGPLVGG 346

                        330       340
                 ....*....|....*....|....*
gi 755525781 396 VIVPVIGFPWLMVIIGTINIIYAPL 420
Cdd:cd17329  347 LLLDLLGPGLPWLILAALGLIAAAL 371
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
85-403 1.12e-13

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 72.63  E-value: 1.12e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  85 IGILFASKALMQLLVNPFVGPLTNR-------------IGYhIPMFVGFMIMFLSTlMFAFSGTYALLFVARTLQGIGSS 151
Cdd:COG2211   48 VGLILLVARLWDAITDPLIGALSDRtrtrwgrrrpwilIGA-IPLALSFVLLFTAP-DLSPTGKLIYALVTYLLLGLAYT 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 152 FSSVAGLGMLASVYTDNYERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLDGALQFCILWPSKVSP 231
Cdd:COG2211  126 LVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTK 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 232 ESAMGTP--------LLTLLKDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFG 303
Cdd:COG2211  206 ERPVPEEekvslkesLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWP 285

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 304 VLANKMGRWLCSLVGMVAVGISLLCVPLA--HNIFGLIGPNAGLGFAIGMVDSSLMPIMGYLVDL-------RHTSVYGS 374
Cdd:COG2211  286 RLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYdewktgrRREGLYFG 365

                        330       340
                 ....*....|....*....|....*....
gi 755525781 375 VYAIADVafcVGFAIGPSTGGVIVPVIGF 403
Cdd:COG2211  366 IFTFAIK---LGQALAGALAGLLLALFGY 391
MFS_1 pfam07690
Major Facilitator Superfamily;
254-435 1.45e-13

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 71.68  E-value: 1.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  254 SICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVGMVAVGISLLCVPLAH 333
Cdd:pfam07690   4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  334 NIFGLIGPNAGLGFAIGMVDSSLMPIMGYLVDLRHtsvYGSVYAIADVAFCVGFAIGPSTGGVIVPVIGFPWLMVIIGTI 413
Cdd:pfam07690  84 SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEE---RGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180
                  ....*....|....*....|..
gi 755525781  414 NIIYAPLCCFLQNPPAKEEELA 435
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKP 182
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
82-421 4.84e-12

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 67.19  E-value: 4.84e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  82 NVRIGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGML 161
Cdd:COG0738   42 DAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYV 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 162 ASVYTDNyeRGRAMgialgglaLGLLVGAPFGSVMYEFVG----KSSPFLILAFLALLDGALQFCIL----------WPS 227
Cdd:COG0738  122 AALGPET--AASRL--------NLLHAFFSLGALLGPLLGglliLLGLSLSWHLPYLILAVLLLLLAllflrsklpeIEE 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 228 KVSPESAMGTPLLTLLKDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLAN 307
Cdd:COG0738  192 EEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLK 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 308 KMGRWLCSLVGMVAVGISLLCVPLAHNIFGLIGPNAGLGFAIGMVDSSLMPIMGYLVDLRHTSVYGSVYAIAdvafCVGF 387
Cdd:COG0738  272 RFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMG----IVGG 347

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 755525781 388 AIGPSTGGVIVPVIGF---PWLMVIIGTINIIYAPLC 421
Cdd:COG0738  348 AIGPPLIGFLADAFGLraaFLVPLVCYLLILLLALAL 384
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 85-410 1.41e-11

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 65.68  E-value: 1.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  85 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAglGMLASV 164
Cdd:cd17330   36 VGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVA--QAYIAD 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 165 YTDNYERGRAMGIALGGLALGLLVGAPFGSVMYEFVGksspflilaflalldgalqfcILWPSKVSPESAMGTPLLTLLK 244
Cdd:cd17330  114 ITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYG---------------------YALPFLVAAALALLNLVLVLFF 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 245 DPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLI-GTNLFGVLANKMGRWLCSLVGMVAVG 323
Cdd:cd17330  173 LPPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILaQLLLIPRLAKRLGERKLLRLGLLLAI 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 324 ISLLCVPLAHNIFGLIGPNAGLGFAIGMVDSSLMPIMGYLVDlrhTSVYGSVYAIADVAFCVGFAIGPSTGGVI--VPVI 401
Cdd:cd17330  253 IGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVP---SKEQGKAQGIIQSLQSLARIIGPLLAGPLysFLGP 329


                 ....*....
gi 755525781 402 GFPWLMVII 410
Cdd:cd17330  330 GVPFLLAAG 338
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 85-418 1.77e-11

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 65.71  E-value: 1.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  85 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAF-----SGTYALLFVARTLQGIGSSFSSVAGLG 159
Cdd:cd06173   36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALlallgSLSLWLLLVLAFLLGIASAFFGPARQA 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 160 MLASVyTDNYERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLDGALQFCILWPSKVSPESAMGTP- 238
Cdd:cd06173  116 LLPEL-VPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLl 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 239 ------LLTLLKDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRW 312
Cdd:cd06173  195 rdlregLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRG 274

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 313 LCSLVGMVAVGISLLCVPLAHNIFGLIGPNAGLGFAIGMVDSSLMPIMGYLVDlrhTSVYGSVYAIADVAFCVGFAIGPS 392
Cdd:cd06173  275 RLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVP---DELRGRVFSVYNALNSGAMPLGAL 351

                        330       340
                 ....*....|....*....|....*.
gi 755525781 393 TGGVIVPVIGFPWLMVIIGTINIIYA 418
Cdd:cd06173  352 LAGLLADALGLSAVFLLAGALLLLAA 377
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 85-424 2.69e-11

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 64.93  E-value: 2.69e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  85 IGILFASKALMQLLVNPFVGPLTNRIGYHIP-MFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFsSVAGLGMLAS 163
Cdd:cd17490   33 IGIILGAYGISQMLLRIPLGILSDRIGKRKLfIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAAT-WVSFTVLYAS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 164 vYTDNYERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLalldGALQFCILWPSKVSPESAMGTP----- 238
Cdd:cd17490  112 -YFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALA----GVLGFILSLFIKEERREKKPVLtelke 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 239 LLTLLKDPYILVAAG-SICLANMGVAILEPTLPIWMMQTMCSpEWQLGLAFLPASVAYLIGTNLFGVLA-NKMGRWLCSL 316
Cdd:cd17490  187 LLSVLKDKKLLFFSLlAILQQMITFSTTFGFTPLIAKQLGAS-SFQLGLLSIIYLLPNALASLLSGTLFyKKLGERNTII 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 317 VGMVAVGISLLCVPLAHNIFGLIGPNAGLGFAIGMVDSSLM--PIMGYLVDLRHTSV--YGSVYAIadvafcvGFAIGPS 392
Cdd:cd17490  266 IGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMslSIEGVPAEQRSTAMgfFQAIYAL-------GMFLGPV 338

                        330       340       350
                 ....*....|....*....|....*....|..
gi 755525781 393 TGGVIVPVIGFPWLMVIIGTINIIYAPLCCFL 424
Cdd:cd17490  339 LVGIISEAFGLQTGFFVIGVIALLAAILSLAY 370
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
248-420 3.94e-11

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 64.22  E-value: 3.94e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 248 ILVAAGSICLANMGVAILEPTLPiWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVGMVAVGISLL 327
Cdd:COG2814   12 LLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 328 CVPLAHNIFGLIGPNAGLGFAIGMVDSSLMPIMGYLVDLRHtsvYGSVYAIADVAFCVGFAIGPSTGGVIVPVIGFPWLM 407
Cdd:COG2814   91 LCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPER---RGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167

                        170
                 ....*....|...
gi 755525781 408 VIIGTINIIYAPL 420
Cdd:COG2814  168 LVNAVLALLALLL 180
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 254-433 4.73e-10

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 61.05  E-value: 4.73e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 254 SICLANMGVAILEPTLPIWMMQTMCSPEwQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVGMVAVGISLLCVPLAH 333
Cdd:cd17325    4 ALFLDMLGYGIIIPILPLYAESLGASVA-QIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFAT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 334 NIFGLIGpnagLGFAIGMVDSSLMPI-MGYLVDLRHTSVYGSVYAIADVAFCVGFAIGPSTGGVIVPVIGFPWLMVIIGT 412
Cdd:cd17325   83 SYWQLLL----ARFLQGLASAAVWPAaMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAA 158

                        170       180
                 ....*....|....*....|.
gi 755525781 413 INIIYAPLCCFLQNPPAKEEE 433
Cdd:cd17325  159 LALLALVLALLLLPEPRPPPN 179
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
85-433 6.38e-10

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 60.66  E-value: 6.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  85 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASV 164
Cdd:COG2223   42 LGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKW 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 165 YTDNyERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLAlldGALQFCILWPSKVSPESAMGTP------ 238
Cdd:COG2223  122 FPPD-RRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILL---LVVAVLAWLFLRDPPAGAAAAAkaslrd 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 239 LLTLLKDP--------YILVAAGSICLANMGVAILEPTLPIWMMQTmcspewqLGLAFLPASVAyLIGTNLFGVLANKMG 310
Cdd:COG2223  198 QLEALRDPrfwllsllYFGTFGSFIGFSSWLPPYLVDQFGLSAATA-------GLLAALFALLG-ALGRPLGGWLSDRIG 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 311 RWLCSLVGMVAVGISLLCVPLA-HNIFGLIGPNAGLGFAIGMVDSSLMPIMGYLVDLRHtsvYGSVYAIADVAFCVGFAI 389
Cdd:COG2223  270 GRRVLLIVFALMALGLLLLALAlGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKN---AGAVYGLVGAAGGLGGFL 346

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 755525781 390 GPSTGGVIVPVIG-FPWLMVIIGTINIIYAPLCCFLQNPPAKEEE 433
Cdd:COG2223  347 GPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLYRRPRRAAA 391
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 85-413 9.17e-10

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 60.28  E-value: 9.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  85 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASV 164
Cdd:cd17474   36 VGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 165 YTDNyERGRAMGIALGGLAlgllvgapFGSVMYEFVG----KSSPFLILAFLALLDGALQFCILWPSKVSPESAMGTPLL 240
Cdd:cd17474  116 FEGG-ERAKAMGLYEAALG--------LGIAVGPLLGgllaAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSAT 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 241 TL------LKDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFG-VLANKMGRWL 313
Cdd:cd17474  187 KLrdlkkaLRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGrLLKKRFGARR 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 314 CSLVGMVAVGISLLCVPLAHNIFGLIGPNAGLGFAIGMVDSSLMPIMGYLVDLRHTSVYGSVYaiaDVAFCVGFAIGPST 393
Cdd:cd17474  267 ILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLY---NFVRFLGQAVGPLL 343

                        330       340
                 ....*....|....*....|
gi 755525781 394 GGVIVPVIGFPWLMVIIGTI 413
Cdd:cd17474  344 FGLLLEIFGLSAPFLVGAAI 363
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 85-413 4.31e-09

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 57.97  E-value: 4.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  85 IGILFASKALMQLlvnpFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASV 164
Cdd:cd17320   40 LSAYLLGFALGQL----LYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 165 YTDNyERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLDGALqFCILWPSKVSPE------SAMGTP 238
Cdd:cd17320  116 YSGA-ELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLL-VLLFLPETLPEEkrkpllSSLLRA 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 239 LLTLLKDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMG-----RWL 313
Cdd:cd17320  194 YKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGprrllRLG 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 314 CSLVGMVAVGISLLCVPLAHNIFGLIGPNAGLGFAIGMVDSSLMPIMgyLVDLRH-----TSVYGSVYAIadVAFCVGFA 388
Cdd:cd17320  274 LLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLA--LEPFPHvagtaSALLGFLQFL--IGALAGAL 349

                        330       340
                 ....*....|....*....|....*
gi 755525781 389 IGPSTGGVIVPvigFPWLMVIIGTI 413
Cdd:cd17320  350 VGLLPNGTALP---MGLLILVLGLL 371
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 101-357 5.42e-09

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 57.95  E-value: 5.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 101 PFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASVYTDNyERGRAMGIALG 180
Cdd:cd17321   49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGE-RRGRALGLWGA 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 181 GLALGLLVGAPFGSVMYEFVGKSSpflilaflalldgalqfcILWpskvspesaMGTP--LLTLLKDPYILVAAGSICLA 258
Cdd:cd17321  128 VVGIGAALGPLLGGLLLELFGWRW------------------IFL---------INVPigLVALLLARTFSGAVLAAFLL 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 259 NMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVGMVAVGISLLCVPLAHN---- 334
Cdd:cd17321  181 GAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGAdssv 260

                        250       260
                 ....*....|....*....|....*.
gi 755525781 335 ---IFGLIGPNAGLGFAIGMVDSSLM 357
Cdd:cd17321  261 wllLPGLVLLGLGLGLFATPLTNAAL 286
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 85-418 2.94e-08

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 55.26  E-value: 2.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  85 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASV 164
Cdd:cd17477   33 IGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNAL 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 165 yTDNYERGRAMGIALGGLALGLLVgapfGSVMYEFVGKSSPFL-ILAFLALLDGALQFCILWPSKVSPESAMGTPLLTLL 243
Cdd:cd17477  113 -ATNENRGRVLGLYSTVLGLGFAL----GPLLLALVGTAGALPfLIAAVLLLLALVPLLLTRRAAPEIEEAESISLRRLL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 244 KdpYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEwQLGLAFLPASVAYLIGTNLFGVLANKMGRwlcSLVGMVAVG 323
Cdd:cd17477  188 R--IAPLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVA-QAALLLAAFVLGGLLLQWPLGWLADRFDR---RRVLLGCAL 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 324 ISLLCVPLAHNIFGLIGPNAGLGFAIGMVDSSLMPI-MGYLVDLRHTSVYGSVYAIADVAFCVGFAIGPSTGGVIVPVIG 402
Cdd:cd17477  262 LGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLaLALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFG 341

                        330
                 ....*....|....*.
gi 755525781 403 FPWLMVIIGTINIIYA 418
Cdd:cd17477  342 PHGLFLFLAAVALLFL 357
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 95-386 3.07e-08

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 55.25  E-value: 3.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  95 MQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVART-LQGIGSSFSSVAGLGMLASvYTDNYeRGR 173
Cdd:cd17352   50 VSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTYGvLGGLGLGLIYSPAIVIVGQ-YFEKK-RGL 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 174 AMGIALGGLALGLLVGAPFGSVMYEFVGksspflilaflalldgaLQFCILWPSKVSPESAMGTPLLTLLKDPYILVAAG 253
Cdd:cd17352  128 ATGIAVAGSGVGTFVFPPLLRYLLDNYG-----------------WRGALLILGGLCLNLCVCGLLLRLLKDPTFVLLAL 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 254 SICLANMGVAILEPTLPIWMMqTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANK--MGRWLCSLVGMVAVGISLLCVPL 331
Cdd:cd17352  191 GVSFAMLGFFVPFVYLPSYAK-SLGIDESDAAFLLSIIGISDIVGRILLGLLADKprIGRLYLYIFTLLILGLSLLAFPL 269

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 755525781 332 AHNIFGLIGPNAGLGFAIGMVDSSLMPIMGYLVDLRH-TSVYGSVYAIADVAFCVG 386
Cdd:cd17352  270 ATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKlSNAYGLVLLFQGLAALVG 325
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
248-435 3.03e-07

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 52.58  E-value: 3.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 248 ILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVGMVAVGISLL 327
Cdd:COG2223    6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 328 CVPLAHNIFGLIGPNAGLGFAIGMVDSSLMPIMGYLVDLRHtsvYGSVYAIADVAFCVGFAIGPSTGGVIVPVIGFPWLM 407
Cdd:COG2223   86 LLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDR---RGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162

                        170       180
                 ....*....|....*....|....*....
gi 755525781 408 VIIGTINIIYAPLC-CFLQNPPAKEEELA 435
Cdd:COG2223  163 LILGILLLVVAVLAwLFLRDPPAGAAAAA 191
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 85-175 4.77e-07

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 51.35  E-value: 4.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  85 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASV 164
Cdd:COG0477   51 LGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAEL 130

                         90
                 ....*....|.
gi 755525781 165 YTDNyERGRAM 175
Cdd:COG0477  131 FPAR-ERGRAL 140
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 248-420 2.32e-06

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 49.04  E-value: 2.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 248 ILVAAGSICLANMGVAILEPTLPIwMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVGMVAVGISLL 327
Cdd:COG0477   16 LLALALGTFLEGLDFTIVNVALPS-IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASL 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 328 CVPLAHNIFGLIGPNAGLGFAIGMVDSSLMPIMGYLVDLRHTSVYGSVYAIAdvaFCVGFAIGPSTGGVIVPVIGFPW-- 405
Cdd:COG0477   95 LCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAA---IGLGLALGPLLGGLLVAALGWRWif 171

                        170
                 ....*....|....*.
gi 755525781 406 -LMVIIGTINIIYAPL 420
Cdd:COG0477  172 lINAPLGLLALVLRLR 187
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 255-430 3.68e-06

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 48.74  E-value: 3.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 255 ICLAN----MGVAILEPTLPIWMMQTMCSPEwQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVGMVAVGISLLCVP 330
Cdd:cd17489    1 ILLANffffLSFYLLLPVLPLYAHDLGGSEA-VAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 331 LAHNIFGLIGPNAGLGFAIGMVDSSLMPIMGYLVDLRHTSVYGSVYAIAdvaFCVGFAIGPSTGGVIVPVIGFPWLMVII 410
Cdd:cd17489   80 LATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLA---TTLAMALGPALGLFLYQHLGFAVLFIVA 156

                        170       180
                 ....*....|....*....|
gi 755525781 411 GTINIIYAPLCCFLQNPPAK 430
Cdd:cd17489  157 AVLALLALLLVFLVKDPPPV 176
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 98-402 5.59e-06

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 48.42  E-value: 5.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  98 LVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASVYTDNYERGRAMGI 177
Cdd:cd17355   53 LAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGI 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 178 ALGGLALGLLVGAPFGSVMYEFVGKSS--------------PFLILAFLALLDGAlqfciLWPSKVSPESAMGTPLLTLL 243
Cdd:cd17355  133 LTAGGGLGSLVFLPLGAALIEAFGWRTallvlallallvlvPVLLLLRRRPADLA-----LRAYDDASPASPGSTLKEAL 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 244 KDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEwQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVGMVAVG 323
Cdd:cd17355  208 RSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPA-AAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRA 286

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 324 ISLLCVPLAHN-IFGLIGPNAGLGFAIGmvdsSLMPIMGYLVDLRH-TSVYGSVYAIADVAFCVGFAIGPSTGGVIVPVI 401
Cdd:cd17355  287 LGLALLLLLPFpPLALLLFAALFGLGWG----ATVPLTAALAARYFgARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRT 362


                 .
gi 755525781 402 G 402
Cdd:cd17355  363 G 363
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 257-432 8.74e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 47.81  E-value: 8.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 257 LANMGVAILEPTLPIWMMQTMCSpEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVGMVAVGISLLCVPLAHNIF 336
Cdd:cd06174    7 LTGLARGLISPLLPALLQSFGLS-ASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFW 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 337 GLIGPNAGLGFAIGMVDSSLMPIMGYLVDLRHTsvyGSVYAIADVAFCVGFAIGPSTGGVIV--PVIGFPWLMVIIGTIN 414
Cdd:cd06174   86 LLLLGRFLLGLGSGLIDPAVLALIADLFPERER---GRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAAALA 162

                        170
                 ....*....|....*...
gi 755525781 415 IIYAPLCCFLQNPPAKEE 432
Cdd:cd06174  163 LLAAILLLLVVPDPPESA 180
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 85-156 1.77e-05

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 46.80  E-value: 1.77e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755525781  85 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSG---TYALLFVARTLQGIGSSFSSVA 156
Cdd:cd17503  216 SGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTpdtSLWLIILPLFIRGLGMGLVFMP 290
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 257-418 6.52e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 44.91  E-value: 6.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 257 LANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVGMVAVGISLLCVPLAHNIF 336
Cdd:cd17329   10 LNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPW 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 337 GLIGPNAGLGFAIGMVDSslmPIMGYLVDLRHTSVYGSVYAIADVAFCVGFAIGPSTGGVIVpVIGFPWLMVIIGTINII 416
Cdd:cd17329   90 LFAIALVLTGFGGGLFEP---ASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLL-LYSFRLLFLAAAVLFLL 165


                 ..
gi 755525781 417 YA 418
Cdd:cd17329  166 AA 167
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 240-397 8.30e-05

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 44.49  E-value: 8.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 240 LTLLKDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSP----EWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCS 315
Cdd:cd17504  171 LRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGfglgITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVL 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 316 LVGMVAVGISLLCVPLAH-NIFGLIGPNAGLGFAIGMVDSSLMPIMGYLVDLRHTSVYGSVYAiadVAFCVGFAIGPSTG 394
Cdd:cd17504  251 LIGLVISAVGLLLLALLHsSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNT---VLRTIGSAIGPAIA 327


                 ...
gi 755525781 395 GVI 397
Cdd:cd17504  328 GAI 330
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 85-175 9.49e-05

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 44.47  E-value: 9.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  85 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASV 164
Cdd:cd17478   33 AGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGARLASQA 112

                         90
                 ....*....|.
gi 755525781 165 YTDNyeRGRAM 175
Cdd:cd17478  113 AGGR--RGLAM 121
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 83-175 5.17e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 42.17  E-value: 5.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  83 VRIGILFASKALMQLLVNPFVGPLTN-RIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGML 161
Cdd:cd17474  234 IIIGLLFAGWSVLLALGSLFVGRLLKkRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLV 313

                         90
                 ....*....|....
gi 755525781 162 ASVyTDNYERGRAM 175
Cdd:cd17474  314 TEL-APEEERGTAS 326
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 93-164 5.80e-04

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 42.21  E-value: 5.80e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755525781  93 ALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAF--SGTYALLFVARTLQGIGSSFSSVAGLGMLASV 164
Cdd:cd17332  266 LSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFlpPGNLVLILVLAVLAGIGYGGANLLPWAMLADV 339
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 102-176 1.15e-03

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 41.02  E-value: 1.15e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755525781 102 FVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGI-GSSFSSVAGlGMLASVYTDNyERGRAMG 176
Cdd:cd17323   53 IWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFfGSSPLAIGA-GTIADLFTPE-ERGKAMG 126
emrD PRK11652
multidrug transporter EmrD;
102-149 1.82e-03

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 40.66  E-value: 1.82e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 755525781 102 FVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIG 149
Cdd:PRK11652  62 FYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLG 109
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 82-423 2.00e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 40.28  E-value: 2.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  82 NVRIGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGssfssVAGLGML 161
Cdd:cd17316   35 LLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIG-----IGGEYPG 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 162 ASVYTDNYERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLDGALqfcilwpskvspesamgTPLLT 241
Cdd:cd17316  110 ASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWRILFLIGAL-----------------PALLA 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 242 LLKDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGR--WLCSLVGM 319
Cdd:cd17316  173 LLLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRkkTLVIGLIL 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 320 VAVGISLLCVPLAHNIFGLIGPNAGLGFAIGMVdSSLMPImgYLVDLRHTSVYGSVYAIADVAFCVGFAIGPSTGGVIVP 399
Cdd:cd17316  253 SGILALPLFYLLSGSPTLLLLLLFILSFFVGGV-WGALYA--YLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLA 329

                        330       340
                 ....*....|....*....|....
gi 755525781 400 VIGFPWLMVIIGTINIIYAPLCCF 423
Cdd:cd17316  330 STGGTGVPALILALLAIVALIVAL 353
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
85-175 2.06e-03

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 40.24  E-value: 2.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  85 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASV 164
Cdd:COG2807   55 AGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRW 134

                         90
                 ....*....|.
gi 755525781 165 YTDNyeRGRAM 175
Cdd:COG2807  135 FPDR--VGLMT 143
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 253-436 3.18e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 39.46  E-value: 3.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 253 GSICLANMGVAILEPTLPIWMMQTMCSPeWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVGMVAVGISLLCVPLA 332
Cdd:cd17477    3 LSVALLGLGSGLLLPLLSLRLEREGVST-ALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 333 HNIFGLIGPNAGLGFAIGMVdssLMPIMGYLVDLRHTSVYGSVYAIADVAFCVGFAIGPSTGGvIVPVIGFPWLMVIIGT 412
Cdd:cd17477   82 DSPWVWFLLRFVMGIGLAGL---FVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLA-LVGTAGALPFLIAAVL 157

                        170       180
                 ....*....|....*....|....
gi 755525781 413 INIIYAPLCCFLQNPPAKEEELAI 436
Cdd:cd17477  158 LLLALVPLLLTRRAAPEIEEAESI 181
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 85-416 3.26e-03

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 39.51  E-value: 3.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  85 IGILFASKALMQLlvnPFvGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGsSFSSVAgLGMLASv 164
Cdd:cd17472   38 LGIYGLTQAIFQI---PF-GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSG-AISSVV-MALLAD- 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 165 YTDNYERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLDGALQFCILWPSKVSPESAMGTP--LLTL 242
Cdd:cd17472  111 LTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEKkkLKKL 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 243 LKDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEwQLGLAFLPASVAYLIGTNLFGVLANKMGR-WLCSLVGMVA 321
Cdd:cd17472  191 LKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKG-QLWKVYLPAILIGFILMVPFVIYAEKKGKmKQVFVSSILL 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 322 VGISLLCV-PLAHNIFGLIgpnagLGFAIGMVDSSLM-PIMGYLV-DLRHTSVYGSVYAIADVAFCVGFAIGPSTGGVIV 398
Cdd:cd17472  270 IAVGFLLLlFAATSLWLLI-----IGLIIFFIGFNLLeALLPSLVsKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLW 344

                        330
                 ....*....|....*...
gi 755525781 399 PVIGFPWLMVIIGTINII 416
Cdd:cd17472  345 GLLGYSSVFLTILILALL 362
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 280-424 4.13e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 39.45  E-value: 4.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 280 PEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVGMVAVGISLLCVPLAHNIFGLIGPNAGLGFAIGMVDSSLMPI 359
Cdd:cd17324   32 SVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAY 111

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755525781 360 MGYLVdlrHTSVYGSVYAIADVAFCVGFAIGPSTGGVIVPVIGFPWLMVIIGTINIIYAPLCCFL 424
Cdd:cd17324  112 AADLV---PPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRL 173
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 85-175 4.23e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 39.48  E-value: 4.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  85 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASV 164
Cdd:cd17473  235 IGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSL 314

                         90
                 ....*....|.
gi 755525781 165 YTDNyERGRAM 175
Cdd:cd17473  315 VPPE-LRGRAM 324
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 282-421 4.65e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 39.10  E-value: 4.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 282 WQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVGMVAVGISLLCVPLAHNIFGLIgpnAGLGFAiGMVDSSLMPIMG 361
Cdd:cd17330   34 YYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLF---LARFLD-GLTGGNVSVAQA 109

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755525781 362 YLVDLRHTSVYGSVYAIADVAFCVGFAIGPSTGGVIVPVIGF---PWLMVIIGTINIIYAPLC 421
Cdd:cd17330  110 YIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYalpFLVAAALALLNLVLVLFF 172
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 84-157 5.85e-03

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 38.77  E-value: 5.85e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755525781  84 RIGILFASKALMQLLVNPFVGPLTNRIGYHiPMFVGFMIMF-LSTLMFAFSGTYALLFVARTLQGIGSSFSSVAG 157
Cdd:cd17388   39 HYGVLLALYALMQFIFAPILGALSDRFGRR-PVLLLSLAGAaLDYLLMAFAPTLWWLYLGRIIAGITGATGAVAA 112
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 256-433 6.86e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 38.75  E-value: 6.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 256 CLANMGVAILEPTLPIWMMQTMCSPEWqLGLAFLPASVAYLIGTNLFGVLANKMGR-WLCSLVGMVAVGISLLCVPLAHN 334
Cdd:cd06173    9 LLSALGDWIFTVALPWLVLQLTGSALL-VGLVLAAFFLPFLLFSPFAGVLADRFDRrRLLILADLLRALLAAVLALLALL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781 335 IFGLIGPNAGLGFAIGMVDSSLMPI-MGYLVDLRHTSVYGSVYAIADVAFCVGFAIGPSTGGVIVPVIGFPWLMVIIGTI 413
Cdd:cd06173   88 GSLSLWLLLVLAFLLGIASAFFGPArQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALS 167

                        170       180
                 ....*....|....*....|
gi 755525781 414 NIIYAPLCCFLQNPPAKEEE 433
Cdd:cd06173  168 FLLSALLLLFIRRPPPAAPG 187
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 85-148 7.24e-03

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 38.36  E-value: 7.24e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755525781  85 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGI 148
Cdd:cd17390   33 IGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGI 96
PRK14995 PRK14995
SmvA family efflux MFS transporter;
94-175 8.48e-03

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 38.56  E-value: 8.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525781  94 LMQLLVNPfVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASVYTDNYERGR 173
Cdd:PRK14995  53 VMAGMVLP-MGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFTEEKQRNM 131


                 ..
gi 755525781 174 AM 175
Cdd:PRK14995 132 AL 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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