NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|755543021|ref|XP_011242468|]
View 

protein Daple isoform X2 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HkD_SF super family cl41774
Hook domain-containing proteins superfamily; The Hook domain superfamily includes Hook adaptor ...
 35-85 1.05e-27

Hook domain-containing proteins superfamily; The Hook domain superfamily includes Hook adaptor proteins, Hook-related proteins and nuclear mitotic apparatus protein (NuMA). They share an N-terminal conserved globular Hook domain, which folds as a variant of the helical calponin homology (CH) domain with an extended alpha-helix. The Hook domain is responsible for the binding of microtubule. The Hook family includes microtubule-binding proteins, Hook1-3. Hook1 is required for spermatid differentiation. Hook2 contributes to the establishment and maintenance of centrosome function. Hook3 is an adaptor protein for microtubule-dependent intracellular vesicle and protein trafficking, and is involved in Golgi and endosome transport. Hook proteins are components of the FTS/Hook/FHIP complex (FHF complex), which may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting (HOPS) complex. The Hook-related protein (HkRP) family includes Daple, Girdin and Gipie. Daple, also called Dvl-associating protein with a high frequency of leucine residues, or coiled-coil domain-containing protein 88C(CCDC88C), or Hook-related protein 2 (HkRP2), is a novel non-receptor nucleotide exchange factor (GEF) required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling. Girdin, also called Akt phosphorylation enhancer (APE), or coiled-coil domain-containing protein 88A (CCDC88A), or G alpha-interacting vesicle-associated protein (GIV), or Girders of actin filament, or Hook-related protein 1 (HkRP1), is a bifunctional modulator of guanine nucleotide-binding proteins (G proteins). Gipie, also called GRP78-interacting protein induced by ER stress, or coiled-coil domain-containing protein 88B(CCDC88B), or brain leucine zipper domain-containing protein, or Hook-related protein 3 (HkRP3), is a novel actin cytoskeleton-binding protein and Akt substrate that regulates cell migratory responses in various biological contexts. NuMA, also called nuclear mitotic apparatus protein 1, or nuclear matrix protein-22 (NMP-22), or SP-H antigen, is a microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignment and the segregation of chromosomes during mitotic cell division.


The actual alignment was detected with superfamily member cd22228:

Pssm-ID: 425405  Cd Length: 153  Bit Score: 110.78  E-value: 1.05e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 755543021   35 GKSMEEIKKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEVTH 85
Cdd:cd22228   103 GKSMEEIKKMLLLVLGCAVQCERKEEFIERIKQLDIETQAAIVSHIQEVTH 153
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 410-1228 1.14e-27

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 122.86  E-value: 1.14e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   410 LEESS--LKYGELEKENQqlsKKIEKLQTQLERekqsnqdLETLSEELIREKEQLQsgmeaLKADRARQIKDLEQEKGHL 487
Cdd:TIGR02168  161 FEEAAgiSKYKERRKETE---RKLERTRENLDR-------LEDILNELERQLKSLE-----RQAEKAERYKELKAELREL 225

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   488 HQAVWSLR------ERPQVNST-KDVEKENRALHQAVTEAGSKLSQLELEKQQLHRDLEEAK-----------EKGEQAE 549
Cdd:TIGR02168  226 ELALLVLRleelreELEELQEElKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQkelyalaneisRLEQQKQ 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   550 ALEKELHRLEKENEQLTKEVTSLKA----ATEKVEALEHQSQGLELENRSLRKSLDTLQNVSVQLEGLERDKQ-QLGQEN 624
Cdd:TIGR02168  306 ILRERLANLERQLEELEAQLEELESkldeLAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEeQLETLR 385

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   625 LELRKMVEAMRFTSAKMAQIETENRQLEREKEELRRDVELLKTLSKKSERLELSYQ--SVSAENLQLQHSLESSTHKSQA 702
Cdd:TIGR02168  386 SKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAEleELEEELEELQEELERLEEALEE 465

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   703 LQRELSQLEAERQALRRDLETLQLTHKQLEGAEEDRKALEQEVAQLEKDKKLLEKEARRLWQQVE--------------- 767
Cdd:TIGR02168  466 LREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISvdegyeaaieaalgg 545

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   768 -LKDAILDDSAAKLSAAEKESRALDKELARCRDVGSKLKELEKDNRDLTKQVTMHTRTLTTLRE-DLVLEKLKSQQLSSE 845
Cdd:TIGR02168  546 rLQAVVVENLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKfDPKLRKALSYLLGGV 625

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   846 L--DKLSQELEKVG-LSKDLLLQEDDGH----------GDGKGKTeSALKTTLAMKEekivfLEAQVEEKESLSRQLQIE 912
Cdd:TIGR02168  626 LvvDDLDNALELAKkLRPGYRIVTLDGDlvrpggvitgGSAKTNS-SILERRREIEE-----LEEKIEELEEKIAELEKA 699

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   913 LQMIKKEHE-------QLRQTQEGGDKAQNALKRPPGKVTSHQEKEAWEPSHKEATMELLRVK------------DRAIE 973
Cdd:TIGR02168  700 LAELRKELEeleeeleQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEieeleerleeaeEELAE 779

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   974 LERSNAALQAERQLLKEQLQHLETQNVSFSSQILTLQKQSAFLQEHTTTLQTQTAKLQVENSTLSSQNAALSAqytvlqs 1053
Cdd:TIGR02168  780 AEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSE------- 852

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1054 QQAAKEAEHEGLQQQQEQLAAVYEALLQdhkhlgtlyecqssEYEALIRQHSCLKTLHRNLELEHKELGERHGDLQQRKA 1133
Cdd:TIGR02168  853 DIESLAAEIEELEELIEELESELEALLN--------------ERASLEEALALLRSELEELSEELRELESKRSELRRELE 918

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1134 ELEELEKVLSTEREALEREQKTNAIATSENQRLrgELDRISFLHQQLKGEYEELHAHTKELKTSLNN-------SQLELS 1206
Cdd:TIGR02168  919 ELREKLAQLELRLEGLEVRIDNLQERLSEEYSL--TLEEAEALENKIEDDEEEARRRLKRLENKIKElgpvnlaAIEEYE 996

                          890       900
                   ....*....|....*....|..
gi 755543021  1207 RWQVRFDELKEQHQSMDISLTK 1228
Cdd:TIGR02168  997 ELKERYDFLTAQKEDLTEAKET 1018
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 188-548 2.75e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 65.85  E-value: 2.75e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   188 RQELEEKTEQLADTRHEVDQLVLELQKAKQDNIQLAADARSARAYRDELD-SLREKANRVERLEMDLVRCKEKLHDVDFY 266
Cdd:TIGR02168  676 RREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSrQISALRKDLARLEAEVEQLEERIAQLSKE 755

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   267 KARMEELREdniiliETKAMLEEQLTASRARSDKVHELEKENLQLKSKLHDLELDRDADKKQIEKLLEEYMVLEMAQKQS 346
Cdd:TIGR02168  756 LTELEAEIE------ELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESL 829

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   347 MKESAHLGWELEQLSKNAdlsdasrksfvfelnECASSRILKLEKENQSLQSTIQGLRDtslALEESSLKYGELEKENQQ 426
Cdd:TIGR02168  830 ERRIAATERRLEDLEEQI---------------EELSEDIESLAAEIEELEELIEELES---ELEALLNERASLEEALAL 891

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   427 LSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEALKADRARQIKDLEQEkghlhqavWSLRERPQVNSTKDV 506
Cdd:TIGR02168  892 LRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEE--------YSLTLEEAEALENKI 963

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755543021   507 EKENRALHQAVTEAGSKLSQL-------------------ELEKQqlHRDLEEAKEKGEQA 548
Cdd:TIGR02168  964 EDDEEEARRRLKRLENKIKELgpvnlaaieeyeelkerydFLTAQ--KEDLTEAKETLEEA 1022
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 1546-1922 1.42e-08

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 60.18  E-value: 1.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1546 PPPrnGPVSQETIQKKGAASTHTGVRPHSASPSSEMvtleefleESNRGGSPTHDTPScrddllsdyfrkAHDPPALGGQ 1625
Cdd:PHA03307   71 PPP--GPGTEAPANESRSTPTWSLSTLAPASPAREG--------SPTPPGPSSPDPPP------------PTPPPASPPP 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1626 PGPPARKDGAKMPTSFVAPTIKMSINTSEGQQLKPGHYVkpnlRPSEAEALAGMPSRQVQPPQslslgrprqttmtqnch 1705
Cdd:PHA03307  129 SPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAA----SSRQAALPLSSPEETARAPS----------------- 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1706 mPVSRSASLSRAFSLASADLLRASGPEACRPESPQ-KPGGHEAAGARETSTHSL----QGSHILARERTPIvgkadsPSP 1780
Cdd:PHA03307  188 -SPPAEPPPSTPPAAASPRPPRRSSPISASASSPApAPGRSAADDAGASSSDSSssesSGCGWGPENECPL------PRP 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1781 GQGTrgrpLDTRRFSLAPPK-EERLAPLQQSATAPALATGCSSGSNPqiqHFSPTVAPAVRTKSKVPQHSGEVATVAPvr 1859
Cdd:PHA03307  261 APIT----LPTRIWEASGWNgPSSRPGPASSSSSPRERSPSPSPSSP---GSGPAPSSPRASSSSSSSRESSSSSTSS-- 331

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755543021 1860 pglgTSEGDGGPGhgyseglltKSPGRSSDLPPHVKRGPDDFSQGSSSKSTPASPEPGGDPQT 1922
Cdd:PHA03307  332 ----SSESSRGAA---------VSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAAS 381
 
Name Accession Description Interval E-value
HkD_Daple cd22228
Hook domain found in Daple (Dvl-associating protein with a high frequency of leucine residues) ...
 35-85 1.05e-27

Hook domain found in Daple (Dvl-associating protein with a high frequency of leucine residues) and similar proteins; Protein Daple, also called coiled-coil domain-containing protein 88C (CCDC88C), or Hook-related protein 2 (HkRP2), is a novel non-receptor nucleotide exchange factor (GEF) required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling.


Pssm-ID: 411799  Cd Length: 153  Bit Score: 110.78  E-value: 1.05e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 755543021   35 GKSMEEIKKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEVTH 85
Cdd:cd22228   103 GKSMEEIKKMLLLVLGCAVQCERKEEFIERIKQLDIETQAAIVSHIQEVTH 153
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 410-1228 1.14e-27

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 122.86  E-value: 1.14e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   410 LEESS--LKYGELEKENQqlsKKIEKLQTQLERekqsnqdLETLSEELIREKEQLQsgmeaLKADRARQIKDLEQEKGHL 487
Cdd:TIGR02168  161 FEEAAgiSKYKERRKETE---RKLERTRENLDR-------LEDILNELERQLKSLE-----RQAEKAERYKELKAELREL 225

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   488 HQAVWSLR------ERPQVNST-KDVEKENRALHQAVTEAGSKLSQLELEKQQLHRDLEEAK-----------EKGEQAE 549
Cdd:TIGR02168  226 ELALLVLRleelreELEELQEElKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQkelyalaneisRLEQQKQ 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   550 ALEKELHRLEKENEQLTKEVTSLKA----ATEKVEALEHQSQGLELENRSLRKSLDTLQNVSVQLEGLERDKQ-QLGQEN 624
Cdd:TIGR02168  306 ILRERLANLERQLEELEAQLEELESkldeLAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEeQLETLR 385

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   625 LELRKMVEAMRFTSAKMAQIETENRQLEREKEELRRDVELLKTLSKKSERLELSYQ--SVSAENLQLQHSLESSTHKSQA 702
Cdd:TIGR02168  386 SKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAEleELEEELEELQEELERLEEALEE 465

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   703 LQRELSQLEAERQALRRDLETLQLTHKQLEGAEEDRKALEQEVAQLEKDKKLLEKEARRLWQQVE--------------- 767
Cdd:TIGR02168  466 LREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISvdegyeaaieaalgg 545

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   768 -LKDAILDDSAAKLSAAEKESRALDKELARCRDVGSKLKELEKDNRDLTKQVTMHTRTLTTLRE-DLVLEKLKSQQLSSE 845
Cdd:TIGR02168  546 rLQAVVVENLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKfDPKLRKALSYLLGGV 625

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   846 L--DKLSQELEKVG-LSKDLLLQEDDGH----------GDGKGKTeSALKTTLAMKEekivfLEAQVEEKESLSRQLQIE 912
Cdd:TIGR02168  626 LvvDDLDNALELAKkLRPGYRIVTLDGDlvrpggvitgGSAKTNS-SILERRREIEE-----LEEKIEELEEKIAELEKA 699

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   913 LQMIKKEHE-------QLRQTQEGGDKAQNALKRPPGKVTSHQEKEAWEPSHKEATMELLRVK------------DRAIE 973
Cdd:TIGR02168  700 LAELRKELEeleeeleQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEieeleerleeaeEELAE 779

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   974 LERSNAALQAERQLLKEQLQHLETQNVSFSSQILTLQKQSAFLQEHTTTLQTQTAKLQVENSTLSSQNAALSAqytvlqs 1053
Cdd:TIGR02168  780 AEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSE------- 852

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1054 QQAAKEAEHEGLQQQQEQLAAVYEALLQdhkhlgtlyecqssEYEALIRQHSCLKTLHRNLELEHKELGERHGDLQQRKA 1133
Cdd:TIGR02168  853 DIESLAAEIEELEELIEELESELEALLN--------------ERASLEEALALLRSELEELSEELRELESKRSELRRELE 918

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1134 ELEELEKVLSTEREALEREQKTNAIATSENQRLrgELDRISFLHQQLKGEYEELHAHTKELKTSLNN-------SQLELS 1206
Cdd:TIGR02168  919 ELREKLAQLELRLEGLEVRIDNLQERLSEEYSL--TLEEAEALENKIEDDEEEARRRLKRLENKIKElgpvnlaAIEEYE 996

                          890       900
                   ....*....|....*....|..
gi 755543021  1207 RWQVRFDELKEQHQSMDISLTK 1228
Cdd:TIGR02168  997 ELKERYDFLTAQKEDLTEAKET 1018
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 169-757 6.05e-26

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 116.96  E-value: 6.05e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  169 DKQHLAVELADTKARLRRVRQELEEKTEQLADTRHEVDQLVLELQKAKQDNIQLAADARSARAyrdeldSLREKANRVER 248
Cdd:COG1196   226 EAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQA------EEYELLAELAR 299

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  249 LEMDLVRCKEKLHDvdfYKARMEELREDNIILIETKAMLEEQLTASRARSDkvhELEKENLQLKSKLHDLELDRDADKKQ 328
Cdd:COG1196   300 LEQDIARLEERRRE---LEERLEELEEELAELEEELEELEEELEELEEELE---EAEEELEEAEAELAEAEEALLEAEAE 373

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  329 IEKLLEEYMVLEMAQKQSMKESAhlgwELEQLSKNADLSDASRKSfvfelnecassRILKLEKENQSLQSTIQGLR---- 404
Cdd:COG1196   374 LAEAEEELEELAEELLEALRAAA----ELAAQLEELEEAEEALLE-----------RLERLEEELEELEEALAELEeeee 438

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  405 DTSLALEESSLKYGELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELiREKEQLQSGMEALKADRARQIKDLEQEK 484
Cdd:COG1196   439 EEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEA-AARLLLLLEAEADYEGFLEGVKAALLLA 517

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  485 G--HLHQAVWSLRERPQVNSTKDVEKENRALHQAVTEAGSKLSQL--ELEKQQLHRDLEEAKEKGEQAEALEKELHRLEK 560
Cdd:COG1196   518 GlrGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAieYLKAAKAGRATFLPLDKIRARAALAAALARGAI 597

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  561 EneqltKEVTSLKAATEKVEALEHQSQGLELENRSLRKSLDTLQNVSVQLEGLERDKQQLGQENLELRKMVEamRFTSAK 640
Cdd:COG1196   598 G-----AAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTG--GSRREL 670

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  641 MAQIETENRQLEREKEELRRDVELLKTLSKKSERLELsyqsvsAENLQLQHSLESSTHKSQALQRELSQLEAERQALRRD 720
Cdd:COG1196   671 LAALLEAEAELEELAERLAEEELELEEALLAEEEEER------ELAEAEEERLEEELEEEALEEQLEAEREELLEELLEE 744

                         570       580       590
                  ....*....|....*....|....*....|....*..
gi 755543021  721 LETLQLTHKQLEGAEEDRKALEQEVAQLEKDKKLLEK 757
Cdd:COG1196   745 EELLEEEALEELPEPPDLEELERELERLEREIEALGP 781
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
176-756 3.73e-20

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 97.83  E-value: 3.73e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  176 ELADTKARLRRVRQELEEKTEQLADTRHEVDQLVLELqkakqdnIQLAADARSARAYRDELDSLREKANRVERLEMDLVR 255
Cdd:PRK03918  180 RLEKFIKRTENIEELIKEKEKELEEVLREINEISSEL-------PELREELEKLEKEVKELEELKEEIEELEKELESLEG 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  256 CKEKLhdvdfyKARMEELREDniilIETKAMLEEQLTASRARSDKVHELEKENLQLKsKLHDLELDRdadKKQIEKLLEE 335
Cdd:PRK03918  253 SKRKL------EEKIRELEER----IEELKKEIEELEEKVKELKELKEKAEEYIKLS-EFYEEYLDE---LREIEKRLSR 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  336 YMVLEMAQKQSMKESAHLGWELEQLSKnaDLSDASRKSFVFELNECASSRILKLEKENQSLQStiqglRDTSLALEESSL 415
Cdd:PRK03918  319 LEEEINGIEERIKELEEKEERLEELKK--KLKELEKRLEELEERHELYEEAKAKKEELERLKK-----RLTGLTPEKLEK 391

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  416 KYGELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREK--------EQLQSGMEALKADRARQIKDLEQEKGHL 487
Cdd:PRK03918  392 ELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKgkcpvcgrELTEEHRKELLEEYTAELKRIEKELKEI 471

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  488 HQAVWSLRER-PQVNSTKDVEKENRALHQAVTEAgsklsqLELEKQQLHRDLEEAKEKGEQAEALEKELHRLEKENEQLT 566
Cdd:PRK03918  472 EEKERKLRKElRELEKVLKKESELIKLKELAEQL------KELEEKLKKYNLEELEKKAEEYEKLKEKLIKLKGEIKSLK 545

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  567 KEVTSLKAATEKVEALEHQSQGLELENRSLRKSLDTLQNVSVqlEGLERDKQQLGQENLELRKMVEAMRFTSAKMAQIET 646
Cdd:PRK03918  546 KELEKLEELKKKLAELEKKLDELEEELAELLKELEELGFESV--EELEERLKELEPFYNEYLELKDAEKELEREEKELKK 623

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  647 ENRQLEREKEELRRDVELLKTLSKKSERLELSYQSVSAENLQlqhslesstHKSQALQRELSQLEAERQALRRDLETLQL 726
Cdd:PRK03918  624 LEEELDKAFEELAETEKRLEELRKELEELEKKYSEEEYEELR---------EEYLELSRELAGLRAELEELEKRREEIKK 694

                         570       580       590
                  ....*....|....*....|....*....|
gi 755543021  727 THKQLEGAEEDRKALEQEVAQLEKDKKLLE 756
Cdd:PRK03918  695 TLEKLKEELEEREKAKKELEKLEKALERVE 724
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 168-1231 1.12e-18

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 93.32  E-value: 1.12e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   168 EDKQHLAVELADTKARLRRVRQELEEKTEQLADTRHEVDQLVLELQKAKqdniQLAADARSARAyrdeldslrEKANRVE 247
Cdd:pfam01576    5 EEMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQAET----ELCAEAEEMRA---------RLAARKQ 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   248 RLEmdlvrckEKLHDVDfykARMEELREDNIIL-IETKAM------LEEQLTASRARSDKVHeLEKENLQLKSKLHD--- 317
Cdd:pfam01576   72 ELE-------EILHELE---SRLEEEEERSQQLqNEKKKMqqhiqdLEEQLDEEEAARQKLQ-LEKVTTEAKIKKLEedi 140

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   318 LELDRDADKKQIEKLLEEYMVLEMaqkqsmkeSAHLGWElEQLSKNADLSDASRKSFVFELNEcassRILKLEKENQSLQ 397
Cdd:pfam01576  141 LLLEDQNSKLSKERKLLEERISEF--------TSNLAEE-EEKAKSLSKLKNKHEAMISDLEE----RLKKEEKGRQELE 207

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   398 STIQGLRDTSLALEESSLKY-GELEKENQQLSKKIEKLQTQLER-EKQSNQDLETLSE--ELIREKEQLQSGMEALKADR 473
Cdd:pfam01576  208 KAKRKLEGESTDLQEQIAELqAQIAELRAQLAKKEEELQAALARlEEETAQKNNALKKirELEAQISELQEDLESERAAR 287

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   474 AR---QIKDLEQE----KGHL---------HQAVWSLRERPQVNSTKDVEKENRALHQAVTEAGSKLSQLelekqqlhrd 537
Cdd:pfam01576  288 NKaekQRRDLGEElealKTELedtldttaaQQELRSKREQEVTELKKALEEETRSHEAQLQEMRQKHTQA---------- 357

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   538 LEEAKEKGEQAE----ALEKELHRLEKENEQLTKEVTSLKAATEKVealEHQSQGLELEnrslrksldtLQNVSVQLEGL 613
Cdd:pfam01576  358 LEELTEQLEQAKrnkaNLEKAKQALESENAELQAELRTLQQAKQDS---EHKRKKLEGQ----------LQELQARLSES 424

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   614 ERDKQQLGQENLELRKMVEAMrftSAKMAQIETENRQLEREKEELRRDVELLKTLSKKSERLELSYQS----VSAENLQL 689
Cdd:pfam01576  425 ERQRAELAEKLSKLQSELESV---SSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQEETRQKLNLSTrlrqLEDERNSL 501

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   690 QHSLESSTHKSQALQRELSQLEAERQALRRDLETLQLThkqLEGAEEDRKALEQEVAQL-------EKDKKLLEKEARRL 762
Cdd:pfam01576  502 QEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDAGT---LEALEEGKKRLQRELEALtqqleekAAAYDKLEKTKNRL 578

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   763 WQQVELKDAILDDSAAKLSAAEKESRALDKELARCRDVGSKLKE---------LEKDNRDLT------------KQVTMH 821
Cdd:pfam01576  579 QQELDDLLVDLDHQRQLVSNLEKKQKKFDQMLAEEKAISARYAEerdraeaeaREKETRALSlaraleealeakEELERT 658

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   822 TRTLTTLREDLVLEKLKSQQLSSELDK----LSQELEKVGLSKDLLLQEDDGHGDGKGKTESALKTTLAMKEEKIVFLEA 897
Cdd:pfam01576  659 NKQLRAEMEDLVSSKDDVGKNVHELERskraLEQQVEEMKTQLEELEDELQATEDAKLRLEVNMQALKAQFERDLQARDE 738

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   898 QVEEK-ESLSRQLQIELQMIKKEHEQLRQTQEGGDKAQNALKRPPGKVtshqekEAWEPSHKEATMELLRVKDRAIELER 976
Cdd:pfam01576  739 QGEEKrRQLVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQI------DAANKGREEAVKQLKKLQAQMKDLQR 812

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   977 SNAALQAERQLLKEQLQHLETQNVSFSSQILTLQKQSAFLQEHTTTLQTQTAKLQVENSTLSSQNAALSAQYTVLQSQQA 1056
Cdd:pfam01576  813 ELEEARASRDEILAQSKESEKKLKNLEAELLQLQEDLAASERARRQAQQERDELADEIASGASGKSALQDEKRRLEARIA 892

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1057 AKEAEHEGLQQQQEQLAAVYEALLQDHKHLGTLYecqSSEYEALIRQHSCLKTLHR-NLELEHKeLGERHGDLQQR-KAE 1134
Cdd:pfam01576  893 QLEEELEEEQSNTELLNDRLRKSTLQVEQLTTEL---AAERSTSQKSESARQQLERqNKELKAK-LQEMEGTVKSKfKSS 968

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1135 LEELEKVLSTEREALEREQKTNAIATSENQRLRGELDRISFL-------HQQLKGEYEELHAHTKELKTSLNNSQLELSR 1207
Cdd:pfam01576  969 IAALEAKIAQLEEQLEQESRERQAANKLVRRTEKKLKEVLLQvederrhADQYKDQAEKGNSRMKQLKRQLEEAEEEASR 1048

                         1130      1140      1150
                   ....*....|....*....|....*....|.
gi 755543021  1208 -------WQVRFDELKEQHQSMDISLTKMDN 1231
Cdd:pfam01576 1049 anaarrkLQRELDDATESNESMNREVSTLKS 1079
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 188-548 2.75e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 65.85  E-value: 2.75e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   188 RQELEEKTEQLADTRHEVDQLVLELQKAKQDNIQLAADARSARAYRDELD-SLREKANRVERLEMDLVRCKEKLHDVDFY 266
Cdd:TIGR02168  676 RREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSrQISALRKDLARLEAEVEQLEERIAQLSKE 755

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   267 KARMEELREdniiliETKAMLEEQLTASRARSDKVHELEKENLQLKSKLHDLELDRDADKKQIEKLLEEYMVLEMAQKQS 346
Cdd:TIGR02168  756 LTELEAEIE------ELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESL 829

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   347 MKESAHLGWELEQLSKNAdlsdasrksfvfelnECASSRILKLEKENQSLQSTIQGLRDtslALEESSLKYGELEKENQQ 426
Cdd:TIGR02168  830 ERRIAATERRLEDLEEQI---------------EELSEDIESLAAEIEELEELIEELES---ELEALLNERASLEEALAL 891

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   427 LSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEALKADRARQIKDLEQEkghlhqavWSLRERPQVNSTKDV 506
Cdd:TIGR02168  892 LRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEE--------YSLTLEEAEALENKI 963

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755543021   507 EKENRALHQAVTEAGSKLSQL-------------------ELEKQqlHRDLEEAKEKGEQA 548
Cdd:TIGR02168  964 EDDEEEARRRLKRLENKIKELgpvnlaaieeyeelkerydFLTAQ--KEDLTEAKETLEEA 1022
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
168-628 3.82e-09

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 61.98  E-value: 3.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  168 EDKQHLAVELADTKARLRRVRQELEEKTEQLADTRHEVDQLVLELQKAKQDNIQLAADARSARAYRDELDSLREKANrvE 247
Cdd:PRK02224  251 EELETLEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELR--D 328

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  248 RLEMDLVRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTASRA----RSDKVHELEKENLQLKSKLHDLELDRD 323
Cdd:PRK02224  329 RLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAREavedRREEIEELEEEIEELRERFGDAPVDLG 408

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  324 ADKKQIEKLLEEymvLEMAQKQSMKESAHLGWELEQLSKNADLSDASR----------KSFVFELNECaSSRILKLEKEN 393
Cdd:PRK02224  409 NAEDFLEELREE---RDELREREAELEATLRTARERVEEAEALLEAGKcpecgqpvegSPHVETIEED-RERVEELEAEL 484

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  394 QSLQSTIQGLRDTSLALEESSlkygELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEA----- 468
Cdd:PRK02224  485 EDLEEEVEEVEERLERAEDLV----EAEDRIERLEERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEEkreaa 560

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  469 ----LKADRARQ-IKDLEQEKGHLHQavwslrERPQVNSTKDVEKENRALHQAVTEAGSKLSQLElEKQQLHRdlEEAKE 543
Cdd:PRK02224  561 aeaeEEAEEAREeVAELNSKLAELKE------RIESLERIRTLLAAIADAEDEIERLREKREALA-ELNDERR--ERLAE 631

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  544 KGEQAEALEKELH--RLEKENEQLTKEVTSLKAATEKVEALEHQSQGL---------ELEN-RSLRKSLDTLQNVSVQLE 611
Cdd:PRK02224  632 KRERKRELEAEFDeaRIEEAREDKERAEEYLEQVEEKLDELREERDDLqaeigavenELEElEELRERREALENRVEALE 711

                         490
                  ....*....|....*..
gi 755543021  612 GLERDKQQLGQENLELR 628
Cdd:PRK02224  712 ALYDEAEELESMYGDLR 728
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
 184-478 5.67e-09

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 60.86  E-value: 5.67e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   184 LRRVRQELEEKTEQLA----DTRHEVDQLVLELQKAKQDNIQLAADARSARAYRDELDSLREKANRVERLEMDLVRCKEK 259
Cdd:pfam05622   64 LQKQLEQLQEENFRLEtardDYRIKCEELEKEVLELQHRNEELTSLAEEAQALKDEMDILRESSDKVKKLEATVETYKKK 143

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   260 LHDVDFYKARMEELREDNIILIETKAMLEEQLtaSRARSDKVH-ELEKENLQLKSKLHDLELDRdADKKQIE--KLLEEY 336
Cdd:pfam05622  144 LEDLGDLRRQVKLLEERNAEYMQRTLQLEEEL--KKANALRGQlETYKRQVQELHGKLSEESKK-ADKLEFEykKLEEKL 220

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   337 MVLE------MAQKQSMKE-----------SAHLGWELEQLSKNADLSD-ASRKSFVFELNEcassRILKLEKENQSLQS 398
Cdd:pfam05622  221 EALQkekerlIIERDTLREtneelrcaqlqQAELSQADALLSPSSDPGDnLAAEIMPAEIRE----KLIRLQHENKMLRL 296

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   399 TIQGLRDTSLA-----LEESSLKYGELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEAL-KAD 472
Cdd:pfam05622  297 GQEGSYRERLTelqqlLEDANRRKNELETQNRLANQRILELQQQVEELQKALQEQGSKAEDSSLLKQKLEEHLEKLhEAQ 376


                   ....*.
gi 755543021   473 RARQIK 478
Cdd:pfam05622  377 SELQKK 382
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1546-1922 1.42e-08

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 60.18  E-value: 1.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1546 PPPrnGPVSQETIQKKGAASTHTGVRPHSASPSSEMvtleefleESNRGGSPTHDTPScrddllsdyfrkAHDPPALGGQ 1625
Cdd:PHA03307   71 PPP--GPGTEAPANESRSTPTWSLSTLAPASPAREG--------SPTPPGPSSPDPPP------------PTPPPASPPP 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1626 PGPPARKDGAKMPTSFVAPTIKMSINTSEGQQLKPGHYVkpnlRPSEAEALAGMPSRQVQPPQslslgrprqttmtqnch 1705
Cdd:PHA03307  129 SPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAA----SSRQAALPLSSPEETARAPS----------------- 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1706 mPVSRSASLSRAFSLASADLLRASGPEACRPESPQ-KPGGHEAAGARETSTHSL----QGSHILARERTPIvgkadsPSP 1780
Cdd:PHA03307  188 -SPPAEPPPSTPPAAASPRPPRRSSPISASASSPApAPGRSAADDAGASSSDSSssesSGCGWGPENECPL------PRP 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1781 GQGTrgrpLDTRRFSLAPPK-EERLAPLQQSATAPALATGCSSGSNPqiqHFSPTVAPAVRTKSKVPQHSGEVATVAPvr 1859
Cdd:PHA03307  261 APIT----LPTRIWEASGWNgPSSRPGPASSSSSPRERSPSPSPSSP---GSGPAPSSPRASSSSSSSRESSSSSTSS-- 331

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755543021 1860 pglgTSEGDGGPGhgyseglltKSPGRSSDLPPHVKRGPDDFSQGSSSKSTPASPEPGGDPQT 1922
Cdd:PHA03307  332 ----SSESSRGAA---------VSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAAS 381
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 168-581 7.60e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 57.64  E-value: 7.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  168 EDKQHLAVELADTKARLRRVRQELEEKTEQLADTRHEVDQLVLELQKAKQDNIQLAADARSARAYRDELDSLREKANRVE 247
Cdd:COG1196   400 AQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAAL 479

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  248 RLEMDLVRCKEKLHDVDFYKARMEELREDNIILIETKAMLE--EQLTASRARSDKVHELEKENLQLKSKLHDLELDRDAD 325
Cdd:COG1196   480 AELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRglAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVA 559

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  326 KKQIEKLLE------EYMVLEMAQKQSMKESAHLGWELEQ--LSKNADLSDASRKSFVFELNECASSRI-LKLEKENQSL 396
Cdd:COG1196   560 AAAIEYLKAakagraTFLPLDKIRARAALAAALARGAIGAavDLVASDLREADARYYVLGDTLLGRTLVaARLEAALRRA 639

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  397 QSTIQGLRDTSLALEESSLKYGELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEALKADRARQ 476
Cdd:COG1196   640 VTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEE 719

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  477 IKDLEQEKghlhQAVWSLRERpqvnstkdVEKENRALHQAVTEAGSKLSQLELEKQQLHRDLEEAKEK----G------- 545
Cdd:COG1196   720 ELEEEALE----EQLEAEREE--------LLEELLEEEELLEEEALEELPEPPDLEELERELERLEREiealGpvnllai 787

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 755543021  546 EQAEALEKELHRLEKENEQLTKEVTSLKAATEKVEA 581
Cdd:COG1196   788 EEYEELEERYDFLSEQREDLEEARETLEEAIEEIDR 823
HOOK_N pfam19047
HOOK domain; This domain is found at the N-terminus of HOOK proteins.
 39-83 2.65e-07

HOOK domain; This domain is found at the N-terminus of HOOK proteins.


Pssm-ID: 465958  Cd Length: 151  Bit Score: 52.02  E-value: 2.65e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 755543021    39 EEIKKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEV 83
Cdd:pfam19047  103 AELGRLLQLILGCAVNCEKKQEYIQQIMTLEESVQHVVMTAIQEL 147
 
Name Accession Description Interval E-value
HkD_Daple cd22228
Hook domain found in Daple (Dvl-associating protein with a high frequency of leucine residues) ...
 35-85 1.05e-27

Hook domain found in Daple (Dvl-associating protein with a high frequency of leucine residues) and similar proteins; Protein Daple, also called coiled-coil domain-containing protein 88C (CCDC88C), or Hook-related protein 2 (HkRP2), is a novel non-receptor nucleotide exchange factor (GEF) required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling.


Pssm-ID: 411799  Cd Length: 153  Bit Score: 110.78  E-value: 1.05e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 755543021   35 GKSMEEIKKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEVTH 85
Cdd:cd22228   103 GKSMEEIKKMLLLVLGCAVQCERKEEFIERIKQLDIETQAAIVSHIQEVTH 153
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 410-1228 1.14e-27

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 122.86  E-value: 1.14e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   410 LEESS--LKYGELEKENQqlsKKIEKLQTQLERekqsnqdLETLSEELIREKEQLQsgmeaLKADRARQIKDLEQEKGHL 487
Cdd:TIGR02168  161 FEEAAgiSKYKERRKETE---RKLERTRENLDR-------LEDILNELERQLKSLE-----RQAEKAERYKELKAELREL 225

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   488 HQAVWSLR------ERPQVNST-KDVEKENRALHQAVTEAGSKLSQLELEKQQLHRDLEEAK-----------EKGEQAE 549
Cdd:TIGR02168  226 ELALLVLRleelreELEELQEElKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQkelyalaneisRLEQQKQ 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   550 ALEKELHRLEKENEQLTKEVTSLKA----ATEKVEALEHQSQGLELENRSLRKSLDTLQNVSVQLEGLERDKQ-QLGQEN 624
Cdd:TIGR02168  306 ILRERLANLERQLEELEAQLEELESkldeLAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEeQLETLR 385

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   625 LELRKMVEAMRFTSAKMAQIETENRQLEREKEELRRDVELLKTLSKKSERLELSYQ--SVSAENLQLQHSLESSTHKSQA 702
Cdd:TIGR02168  386 SKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAEleELEEELEELQEELERLEEALEE 465

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   703 LQRELSQLEAERQALRRDLETLQLTHKQLEGAEEDRKALEQEVAQLEKDKKLLEKEARRLWQQVE--------------- 767
Cdd:TIGR02168  466 LREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISvdegyeaaieaalgg 545

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   768 -LKDAILDDSAAKLSAAEKESRALDKELARCRDVGSKLKELEKDNRDLTKQVTMHTRTLTTLRE-DLVLEKLKSQQLSSE 845
Cdd:TIGR02168  546 rLQAVVVENLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKfDPKLRKALSYLLGGV 625

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   846 L--DKLSQELEKVG-LSKDLLLQEDDGH----------GDGKGKTeSALKTTLAMKEekivfLEAQVEEKESLSRQLQIE 912
Cdd:TIGR02168  626 LvvDDLDNALELAKkLRPGYRIVTLDGDlvrpggvitgGSAKTNS-SILERRREIEE-----LEEKIEELEEKIAELEKA 699

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   913 LQMIKKEHE-------QLRQTQEGGDKAQNALKRPPGKVTSHQEKEAWEPSHKEATMELLRVK------------DRAIE 973
Cdd:TIGR02168  700 LAELRKELEeleeeleQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEieeleerleeaeEELAE 779

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   974 LERSNAALQAERQLLKEQLQHLETQNVSFSSQILTLQKQSAFLQEHTTTLQTQTAKLQVENSTLSSQNAALSAqytvlqs 1053
Cdd:TIGR02168  780 AEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSE------- 852

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1054 QQAAKEAEHEGLQQQQEQLAAVYEALLQdhkhlgtlyecqssEYEALIRQHSCLKTLHRNLELEHKELGERHGDLQQRKA 1133
Cdd:TIGR02168  853 DIESLAAEIEELEELIEELESELEALLN--------------ERASLEEALALLRSELEELSEELRELESKRSELRRELE 918

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1134 ELEELEKVLSTEREALEREQKTNAIATSENQRLrgELDRISFLHQQLKGEYEELHAHTKELKTSLNN-------SQLELS 1206
Cdd:TIGR02168  919 ELREKLAQLELRLEGLEVRIDNLQERLSEEYSL--TLEEAEALENKIEDDEEEARRRLKRLENKIKElgpvnlaAIEEYE 996

                          890       900
                   ....*....|....*....|..
gi 755543021  1207 RWQVRFDELKEQHQSMDISLTK 1228
Cdd:TIGR02168  997 ELKERYDFLTAQKEDLTEAKET 1018
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 183-998 8.03e-27

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 120.16  E-value: 8.03e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   183 RLRRVRQELEekteQLADTRHEVD-QLV-LELQkakqdniqlaadARSARAYRDELDSLREKANRVerLEMDLVRCKEKL 260
Cdd:TIGR02168  180 KLERTRENLD----RLEDILNELErQLKsLERQ------------AEKAERYKELKAELRELELAL--LVLRLEELREEL 241

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   261 HDVDFYKARMEELREDniiLIETKAMLEEQLTASRAR----SDKVHELEKENLQLKSKLHDLELDRDADKKQIEKLLEEY 336
Cdd:TIGR02168  242 EELQEELKEAEEELEE---LTAELQELEEKLEELRLEvselEEEIEELQKELYALANEISRLEQQKQILRERLANLERQL 318

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   337 MVLEMAQKQSMKESAHLGWELEQLSKNADlsdasrksfvfELNECASSRILKLEKENQSLQSTIQGLRDTSLALEESSLK 416
Cdd:TIGR02168  319 EELEAQLEELESKLDELAEELAELEEKLE-----------ELKEELESLEAELEELEAELEELESRLEELEEQLETLRSK 387

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   417 YGELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEqlqsgmEALKADRARQIKDLEQEKGHLHQAVWSLRE 496
Cdd:TIGR02168  388 VAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLE------EAELKELQAELEELEEELEELQEELERLEE 461

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   497 RpqvnsTKDVEKENRALHQAVTEAGSKLSQLELEKQQLHRDLEEAKEKGEQAEALEKELHRLE------------KENEQ 564
Cdd:TIGR02168  462 A-----LEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSgilgvlselisvDEGYE 536

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   565 LTKE-----------VTSLKAATEKVEALEHQSQG----LELENRSLRKSLDTLQNVSVQLEGLERDKQQLGQENLELRK 629
Cdd:TIGR02168  537 AAIEaalggrlqavvVENLNAAKKAIAFLKQNELGrvtfLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRK 616

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   630 MVEAMRFTSAKMAQIETENRQLEREKEELR---RDVELLKT---LSKKSERLELSYQSVSAENLQLQHSLESSTHKSQAL 703
Cdd:TIGR02168  617 ALSYLLGGVLVVDDLDNALELAKKLRPGYRivtLDGDLVRPggvITGGSAKTNSSILERRREIEELEEKIEELEEKIAEL 696

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   704 QRELSQLEAERQALRRDLETLQL----THKQLEGAEEDRKALEQEVAQLEKDKKLLEKEARRLWQQVELKDAILDDSAAK 779
Cdd:TIGR02168  697 EKALAELRKELEELEEELEQLRKeleeLSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEE 776

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   780 LSAAEKESRALDKELA-------------------------RCRDVGSKLKELEKDNRDLTKQVTMHTRTLTTLREDLVL 834
Cdd:TIGR02168  777 LAEAEAEIEELEAQIEqlkeelkalrealdelraeltllneEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIES 856

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   835 EKLKSQQLSSELDKLSQELEKVGLSKDLLLQEDDGHGDGKGKTESALKTTlamkEEKIVFLEAQVEEKESLSRQLQIELQ 914
Cdd:TIGR02168  857 LAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELREL----ESKRSELRRELEELREKLAQLELRLE 932

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   915 MIKKEHEQLRQ--TQEGGDKAQNALKRPPGKVTSHQEKEAWEPSHKEATMELLRVKDRAIElersnaalqaERQLLKEQL 992
Cdd:TIGR02168  933 GLEVRIDNLQErlSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKELGPVNLAAIE----------EYEELKERY 1002


                   ....*.
gi 755543021   993 QHLETQ 998
Cdd:TIGR02168 1003 DFLTAQ 1008
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 299-1155 1.33e-26

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 119.39  E-value: 1.33e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   299 DKVHELEK--ENLQLKSKLHD--LELDRDADKKQIEKLLEEYMVLEMAQKQSMKESAHLGWELEQLSKNADLSDASRKSF 374
Cdd:TIGR02168  193 DILNELERqlKSLERQAEKAEryKELKAELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEEL 272

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   375 VFELNEcASSRILKLEKENQSLQSTIQGLrdtslaleESSLKygELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEE 454
Cdd:TIGR02168  273 RLEVSE-LEEEIEELQKELYALANEISRL--------EQQKQ--ILRERLANLERQLEELEAQLEELESKLDELAEELAE 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   455 LIREKEQLQSGMEALKAdrarQIKDLEQEKGHLHQAVWSLRE-RPQVNSTKDVEKENRALHQA-VTEAGSKLSQLELEKQ 532
Cdd:TIGR02168  342 LEEKLEELKEELESLEA----ELEELEAELEELESRLEELEEqLETLRSKVAQLELQIASLNNeIERLEARLERLEDRRE 417

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   533 QLHRDLEEA---------KEKGEQAEALEKELHRLEKENEQLtkeVTSLKAATEKVEALEHQSQGLELENRSLRKSLDTL 603
Cdd:TIGR02168  418 RLQQEIEELlkkleeaelKELQAELEELEEELEELQEELERL---EEALEELREELEEAEQALDAAERELAQLQARLDSL 494

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   604 QNVSVQLEGLERDKQQLGQENLELRKMV----EAMRFTSAKMAQIET---ENRQ--LEREKEELRRDVELLK-TLSKKSE 673
Cdd:TIGR02168  495 ERLQENLEGFSEGVKALLKNQSGLSGILgvlsELISVDEGYEAAIEAalgGRLQavVVENLNAAKKAIAFLKqNELGRVT 574

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   674 RLELSyqsvSAENLQLQHSLESSTHKSQALQRELSQLEAERQALRRDLETLqLTH----KQLEGAEEDRKALEQEVAQLE 749
Cdd:TIGR02168  575 FLPLD----SIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYL-LGGvlvvDDLDNALELAKKLRPGYRIVT 649

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   750 KDKKLL-----------EKEARRLWQQVELKDAilddsAAKLSAAEKESRALDKELARCRDvgsKLKELEKDNRDLTKQV 818
Cdd:TIGR02168  650 LDGDLVrpggvitggsaKTNSSILERRREIEEL-----EEKIEELEEKIAELEKALAELRK---ELEELEEELEQLRKEL 721

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   819 TMHTRTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLSKDLLLQEddghgdgKGKTESALKTTlamkEEKIVFLEAQ 898
Cdd:TIGR02168  722 EELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEER-------LEEAEEELAEA----EAEIEELEAQ 790

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   899 VEEkesLSRQLQIELQMIKKEHEQLRQTQEGGDKAQNALKRppgkvtSHQEKEAWEpshkeatmellrvkDRAIELERSN 978
Cdd:TIGR02168  791 IEQ---LKEELKALREALDELRAELTLLNEEAANLRERLES------LERRIAATE--------------RRLEDLEEQI 847

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   979 AALQAERQLLKEQLQHLETQNVSFSSQILTLQKQSAFLQEHTTTLQTQTAKLQVENSTLSSQNAALSAQYTVLQSQQAAK 1058
Cdd:TIGR02168  848 EELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQL 927

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1059 EAEHEGLQQQ----QEQLAAVYEALLQDHKHLGTLYECQSSEYEALIRQH-SCLKTLHR-NLEL--EHKELGERHGDLQQ 1130
Cdd:TIGR02168  928 ELRLEGLEVRidnlQERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLeNKIKELGPvNLAAieEYEELKERYDFLTA 1007

                          890       900       910
                   ....*....|....*....|....*....|
gi 755543021  1131 RKAELEE----LEKVLS-TEREALEREQKT 1155
Cdd:TIGR02168 1008 QKEDLTEaketLEEAIEeIDREARERFKDT 1037
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 169-757 6.05e-26

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 116.96  E-value: 6.05e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  169 DKQHLAVELADTKARLRRVRQELEEKTEQLADTRHEVDQLVLELQKAKQDNIQLAADARSARAyrdeldSLREKANRVER 248
Cdd:COG1196   226 EAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQA------EEYELLAELAR 299

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  249 LEMDLVRCKEKLHDvdfYKARMEELREDNIILIETKAMLEEQLTASRARSDkvhELEKENLQLKSKLHDLELDRDADKKQ 328
Cdd:COG1196   300 LEQDIARLEERRRE---LEERLEELEEELAELEEELEELEEELEELEEELE---EAEEELEEAEAELAEAEEALLEAEAE 373

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  329 IEKLLEEYMVLEMAQKQSMKESAhlgwELEQLSKNADLSDASRKSfvfelnecassRILKLEKENQSLQSTIQGLR---- 404
Cdd:COG1196   374 LAEAEEELEELAEELLEALRAAA----ELAAQLEELEEAEEALLE-----------RLERLEEELEELEEALAELEeeee 438

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  405 DTSLALEESSLKYGELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELiREKEQLQSGMEALKADRARQIKDLEQEK 484
Cdd:COG1196   439 EEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEA-AARLLLLLEAEADYEGFLEGVKAALLLA 517

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  485 G--HLHQAVWSLRERPQVNSTKDVEKENRALHQAVTEAGSKLSQL--ELEKQQLHRDLEEAKEKGEQAEALEKELHRLEK 560
Cdd:COG1196   518 GlrGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAieYLKAAKAGRATFLPLDKIRARAALAAALARGAI 597

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  561 EneqltKEVTSLKAATEKVEALEHQSQGLELENRSLRKSLDTLQNVSVQLEGLERDKQQLGQENLELRKMVEamRFTSAK 640
Cdd:COG1196   598 G-----AAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTG--GSRREL 670

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  641 MAQIETENRQLEREKEELRRDVELLKTLSKKSERLELsyqsvsAENLQLQHSLESSTHKSQALQRELSQLEAERQALRRD 720
Cdd:COG1196   671 LAALLEAEAELEELAERLAEEELELEEALLAEEEEER------ELAEAEEERLEEELEEEALEEQLEAEREELLEELLEE 744

                         570       580       590
                  ....*....|....*....|....*....|....*..
gi 755543021  721 LETLQLTHKQLEGAEEDRKALEQEVAQLEKDKKLLEK 757
Cdd:COG1196   745 EELLEEEALEELPEPPDLEELERELERLEREIEALGP 781
HkD_HkRP cd22223
Hook domain found in the Hook-related protein (HkRP) family; The HkRP family includes Daple, ...
 37-85 1.41e-24

Hook domain found in the Hook-related protein (HkRP) family; The HkRP family includes Daple, Girdin and Gipie. Daple, also called Dvl-associating protein with a high frequency of leucine residues, or coiled-coil domain-containing protein 88C (CCDC88C), or Hook-related protein 2 (HkRP2), is a novel non-receptor nucleotide exchange factor (GEF) required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling. Girdin, also called Akt phosphorylation enhancer (APE), or coiled-coil domain-containing protein 88A (CCDC88A), or G alpha-interacting vesicle-associated protein (GIV), or Girders of actin filament, or Hook-related protein 1 (HkRP1), is a bifunctional modulator of guanine nucleotide-binding proteins (G proteins). It acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits. It also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS. In addition, Girdin plays an essential role in cell migration. Gipie, also called GRP78-interacting protein induced by ER stress, or coiled-coil domain-containing protein 88B (CCDC88B), or brain leucine zipper domain-containing protein, or Hook-related protein 3 (HkRP3), is a novel actin cytoskeleton-binding protein and Akt substrate that regulates cell migratory responses in various biological contexts. It acts as a positive regulator of T-cell maturation and inflammatory function. As a microtubule-binding protein, Gipie regulates lytic granule clustering and NK cell killing. All family members contain a conserved globular Hook domain which folds as a variant of the helical calponin homology (CH) domain.


Pssm-ID: 411794  Cd Length: 149  Bit Score: 101.51  E-value: 1.41e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 755543021   37 SMEEIKKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEVTH 85
Cdd:cd22223   101 SLEELEKLLLLLLGCAVQCERKEEFIERIKNLDLEVQHALVACIQEVTD 149
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 176-796 4.19e-24

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 110.80  E-value: 4.19e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  176 ELADTKARLRRV---RQELE----------EKTEQLADTRHEVDQLVLELQKAKQDNIQlaADARSARAYRDELDSLREK 242
Cdd:COG1196   180 KLEATEENLERLediLGELErqleplerqaEKAERYRELKEELKELEAELLLLKLRELE--AELEELEAELEELEAELEE 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  243 AN-RVERLEMDLVRCKEKLHDVDfykARMEELREDNIILIETKAMLEEQLTASRARSdkvHELEKENLQLKSKLHDLELD 321
Cdd:COG1196   258 LEaELAELEAELEELRLELEELE---LELEEAQAEEYELLAELARLEQDIARLEERR---RELEERLEELEEELAELEEE 331

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  322 RDADKKQIEKLLEEYMVLEMAQKQSMKESAHLGWELEQLSKNADLSDASRKSFVFELNEcASSRILKLEKENQSLQSTIQ 401
Cdd:COG1196   332 LEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLE-ALRAAAELAAQLEELEEAEE 410

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  402 GLRDTSLALEEsslkygelekENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEALKADRARQIKDLE 481
Cdd:COG1196   411 ALLERLERLEE----------ELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALA 480

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  482 QEKGHLHQAvwslreRPQVNSTKDVEKENRALHQAVTEAGSKLSQLELEKQ-QLHRDLEEAKEKGEQAEALEKELHRLEK 560
Cdd:COG1196   481 ELLEELAEA------AARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAvAVLIGVEAAYEAALEAALAAALQNIVVE 554

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  561 ENEQLTKEVTSLKAATEKVEALehqsqgLELENRSLRKSLDTLQNVSVQLEGLERDKQQLGQENLELRKMVEAMRFTSAK 640
Cdd:COG1196   555 DDEVAAAAIEYLKAAKAGRATF------LPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLV 628

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  641 MAQIETENRQLEREKEELRRDVELLKTLSKKSERLELSYQSVSAENLQLQHSLEssthksQALQRELSQLEAERQALRRD 720
Cdd:COG1196   629 AARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELE------ELAERLAEEELELEEALLAE 702

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755543021  721 LETLQLTHKQLEGAEEDRKALEQEVAQLEKDKKLLEKEARRLWQQVELKDAILDDSAAKLSAAEKESRALDKELAR 796
Cdd:COG1196   703 EEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEA 778
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 173-998 5.71e-24

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 110.54  E-value: 5.71e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   173 LAVELADTKARLRRVRQELEEKTEQLADTRHEVDQLVLELQKAKQDNIQLAADAR-----SARAYRDEL----------- 236
Cdd:TIGR02169  228 LLKEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKdlgeeEQLRVKEKIgeleaeiasle 307

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   237 DSLREKANRVERLEMDLVRCKEKLHDvdfYKARMEELREDniilIETKAMLEEQLTASRARSDKVHELEKENLQLKSKLH 316
Cdd:TIGR02169  308 RSIAEKERELEDAEERLAKLEAEIDK---LLAEIEELERE----IEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEF 380

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   317 DLELDRDAD-KKQIEKLLEEYMVLEMAQKQSMKESAHLGWELEQLskNADLSDASRKsfVFELNECASSRILKLEKENQS 395
Cdd:TIGR02169  381 AETRDELKDyREKLEKLKREINELKRELDRLQEELQRLSEELADL--NAAIAGIEAK--INELEEEKEDKALEIKKQEWK 456

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   396 LQSTIQGLRDTSLALEESSLKYGELEKENQQLSKKIEKLQTQ---LEREKQSNQDLETLSEELIRekeqlqsGMEALKAD 472
Cdd:TIGR02169  457 LEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQaraSEERVRGGRAVEEVLKASIQ-------GVHGTVAQ 529

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   473 ----RARQIKDLEQEKGHLHQAVwslrerpqVNSTKDVEKEnrALHQAVTEAGSKLSQLELEK-QQLHRDLEEAKEKGEQ 547
Cdd:TIGR02169  530 lgsvGERYATAIEVAAGNRLNNV--------VVEDDAVAKE--AIELLKRRKAGRATFLPLNKmRDERRDLSILSEDGVI 599

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   548 AEALEkeLHRLEKENEQLTKEV---TSLKAATEKVEALEHQSQGLELENRSLRKSlDTLQNVSVQLEGLERDKQQLGQEN 624
Cdd:TIGR02169  600 GFAVD--LVEFDPKYEPAFKYVfgdTLVVEDIEAARRLMGKYRMVTLEGELFEKS-GAMTGGSRAPRGGILFSRSEPAEL 676

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   625 LELRKMVEAMRftsAKMAQIETENRQLEREKEELRRdveLLKTLSKKSERLELSYQSVSAENLQLQHSLESSTHKSQALQ 704
Cdd:TIGR02169  677 QRLRERLEGLK---RELSSLQSELRRIENRLDELSQ---ELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLE 750

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   705 RELSQLEAERQALRRDLETLQLTHKQLEGAEED--RKALEQEVAQLEKDKKLLEKEARRLwqqvelkDAILDDSAAKLsa 782
Cdd:TIGR02169  751 QEIENVKSELKELEARIEELEEDLHKLEEALNDleARLSHSRIPEIQAELSKLEEEVSRI-------EARLREIEQKL-- 821

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   783 aekESRALDKELARcrdvgSKLKELEKDNRDLTKQVTMHTRTLTTLREDLvlEKLKSQQLSSELDKLSQELEKVGLSKDL 862
Cdd:TIGR02169  822 ---NRLTLEKEYLE-----KEIQELQEQRIDLKEQIKSIEKEIENLNGKK--EELEEELEELEAALRDLESRLGDLKKER 891

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   863 llqeddghgdgkgkteSALKTTLAMKEEKIVFLEAQVEEKESLSRQLQIELQMIKKEHEQLrqtqeggDKAQNALKRPPG 942
Cdd:TIGR02169  892 ----------------DELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEI-------EDPKGEDEEIPE 948

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755543021   943 KVTS-----------HQEKEAWEPSHKEATMELLRVKDRAIELERSNAALQAERQLLKEQLQHLETQ 998
Cdd:TIGR02169  949 EELSledvqaelqrvEEEIRALEPVNMLAIQEYEEVLKRLDELKEKRAKLEEERKAILERIEEYEKK 1015
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 594-1301 1.58e-23

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 109.38  E-value: 1.58e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   594 RSLRKSLDTLQNVSVQLEGLERDKQQLgqENLELRkmVEAMRFTSAKmAQIETENRQLEREKEELRRDVELLKTLSKKSE 673
Cdd:TIGR02168  196 NELERQLKSLERQAEKAERYKELKAEL--RELELA--LLVLRLEELR-EELEELQEELKEAEEELEELTAELQELEEKLE 270

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   674 RLELSYQSVSAENLQLQHSLESSTHKSQALQRELSQLEAERQALRRDLETLQLthkQLEGAEEDRKALEQEVAQLEKDKK 753
Cdd:TIGR02168  271 ELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEA---QLEELESKLDELAEELAELEEKLE 347

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   754 LLEKEarrlwqqVELKDAILDDSAAKLSAAEKESRALDKElarcrdvgskLKELEKDNRDLTKQVTMHTRTLTTLREDLv 833
Cdd:TIGR02168  348 ELKEE-------LESLEAELEELEAELEELESRLEELEEQ----------LETLRSKVAQLELQIASLNNEIERLEARL- 409

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   834 leklksQQLSSELDKLSQELEKVGLSKDLL-LQEDDGHGDGKGKTESALKTTLAMKEEKIVFLEAQVEEKESLSRQLQIE 912
Cdd:TIGR02168  410 ------ERLEDRRERLQQEIEELLKKLEEAeLKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERE 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   913 LQ-------MIKKEHEQLRQTQEGGDKAQNALKRPPGKVTSHQEKEAWEPSHKEATMELLRVKDRAIELERSNAALQA-- 983
Cdd:TIGR02168  484 LAqlqarldSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISVDEGYEAAIEAALGGRLQAVVVENLNAAKKAia 563

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   984 -------------------ERQLLKEQLQHLETQNvSFSSQILTLQKQSAFLQEH----------TTTLQTQTAKL---- 1030
Cdd:TIGR02168  564 flkqnelgrvtflpldsikGTEIQGNDREILKNIE-GFLGVAKDLVKFDPKLRKAlsyllggvlvVDDLDNALELAkklr 642

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1031 ------------------------QVENSTLSSQN--AALSAQYTVLQSQQAAKEAEHEGLQQQQEQLAAVYEALLQDHK 1084
Cdd:TIGR02168  643 pgyrivtldgdlvrpggvitggsaKTNSSILERRReiEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELE 722

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1085 HLGTLYECQSSEYEALIRQHSCLKTLHRNLELEHKELGERHGDLQQRKAELEELEKVLSTEREALEREQKTNAIATSENQ 1164
Cdd:TIGR02168  723 ELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALR 802

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1165 R----LRGELDRISFLHQQLKGEYEELHAHTKELKTSLNNSQLELSRWQVRFDELKEQHQSMDISLTKMDNHCELLSRLK 1240
Cdd:TIGR02168  803 EaldeLRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNER 882

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755543021  1241 GNLEEENHHLLSQIQLLSQQNQMLLEQNMESKEQYHEEQkqyiDKLNALRRHKEKLEEKIM 1301
Cdd:TIGR02168  883 ASLEEALALLRSELEELSEELRELESKRSELRRELEELR----EKLAQLELRLEGLEVRID 939
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 426-1300 3.00e-23

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 108.23  E-value: 3.00e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   426 QLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSgmEALKADRarqIKDLEQEKGHLHQAVWSLRERPQVNSTKD 505
Cdd:TIGR02169  167 EFDRKKEKALEELEEVEENIERLDLIIDEKRQQLERLRR--EREKAER---YQALLKEKREYEGYELLKEKEALERQKEA 241

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   506 VEKENRALHQAVTEAGSKLSQLELEKQQLHRDLEEAKEK-----GEQAEALEKELHRLEKENEQLtkeVTSLKAATEKVE 580
Cdd:TIGR02169  242 IERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKikdlgEEEQLRVKEKIGELEAEIASL---ERSIAEKERELE 318

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   581 ALEHQSQGLELEnrsLRKSLDTLQNVSVQLEGLERDKQQLGQENLELRKMVEAMR-----------FTSAKMAQIETENR 649
Cdd:TIGR02169  319 DAEERLAKLEAE---IDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRaeleevdkefaETRDELKDYREKLE 395

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   650 QLEREKEELRRDV----ELLKTLSKKSERLELSYQSVSAENLQLQHSLESSTHKSQALQRELSQLEAERQALRRDLETLQ 725
Cdd:TIGR02169  396 KLKREINELKRELdrlqEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLK 475

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   726 LTHKQLEgaeEDRKALEQEVAQLEKDKKLLEKEARRLWQQVELKDAILDD---SAAKLSAAeKESRALDKELArcrdVGS 802
Cdd:TIGR02169  476 EEYDRVE---KELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGvhgTVAQLGSV-GERYATAIEVA----AGN 547

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   803 KLKELEKDNRDLTKQVTMHTRTLTTLRED-LVLEKLKSQQlsSELDKLSQElEKVGLSKDLLLQEDdghgdgkgKTESAL 881
Cdd:TIGR02169  548 RLNNVVVEDDAVAKEAIELLKRRKAGRATfLPLNKMRDER--RDLSILSED-GVIGFAVDLVEFDP--------KYEPAF 616

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   882 KttlamkeekIVFLEAQVEEKESLSRQLQIELQMIKKEHEQLrqtQEGGDKAQNALKRPPGKVTSHQEKEawepshkeat 961
Cdd:TIGR02169  617 K---------YVFGDTLVVEDIEAARRLMGKYRMVTLEGELF---EKSGAMTGGSRAPRGGILFSRSEPA---------- 674

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   962 mELLRVKDRAIELERSNAALQAERQLLKEQLQHLETQNVSFSSQILTLQKQSAFLQEHTTTLQTQTAKLQVENSTLSSQN 1041
Cdd:TIGR02169  675 -ELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEI 753

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1042 AALSAQYTVLQSQQAAKEAEHEGLQQQQEQLAAVY--EALLQDHKHLGTLYECQSSEYEALIRQHSCLKTLHRNLEL--- 1116
Cdd:TIGR02169  754 ENVKSELKELEARIEELEEDLHKLEEALNDLEARLshSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYlek 833

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1117 EHKELGERHGDLQQRKAELEELEKVLSTEREALEREQKtnaiatsenqRLRGELDRISFLHQQLKGEYEELHAHTKELKT 1196
Cdd:TIGR02169  834 EIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELE----------ELEAALRDLESRLGDLKKERDELEAQLRELER 903

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1197 SLNNSQLELSRWQVRFDELKEQHQSMDISLTKMDnhcellsRLKGNLEEENHHLLS------QIQLLSQQNQMLLEQNME 1270
Cdd:TIGR02169  904 KIEELEAQIEKKRKRLSELKAKLEALEEELSEIE-------DPKGEDEEIPEEELSledvqaELQRVEEEIRALEPVNML 976

                          890       900       910
                   ....*....|....*....|....*....|...
gi 755543021  1271 SKEQYHEEQKQYID---KLNALRRHKEKLEEKI 1300
Cdd:TIGR02169  977 AIQEYEEVLKRLDElkeKRAKLEEERKAILERI 1009
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 174-854 6.66e-22

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 103.98  E-value: 6.66e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   174 AVELADTKARLRRVRQELEEKTEQLADTRHEVDQLVLELQKAKQD----NIQLAADARSARAYRDELDSLrekANRVERL 249
Cdd:TIGR02168  224 ELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKleelRLEVSELEEEIEELQKELYAL---ANEISRL 300

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   250 EMDLVRCKEKLHDVD----FYKARMEELREDNIILIETKAMLEEQLTASRARSDkvhELEKENLQLKSKLHDLELDRDAD 325
Cdd:TIGR02168  301 EQQKQILRERLANLErqleELEAQLEELESKLDELAEELAELEEKLEELKEELE---SLEAELEELEAELEELESRLEEL 377

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   326 KKQIEKLLEEYMVLEMAQKQSMKESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRI-LKLEKENQSLQSTIQGLR 404
Cdd:TIGR02168  378 EEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELqAELEELEEELEELQEELE 457

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   405 DTSLALEESSLKYGELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSE--------------------ELIREKEQLQS 464
Cdd:TIGR02168  458 RLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEgvkallknqsglsgilgvlsELISVDEGYEA 537

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   465 GMEALKADRARQI--KDLEQEK---GHLHQAVWSLRERPQVNSTKDVEKENRALHQAVTEAGSKLSQLELEKQ--QLHRD 537
Cdd:TIGR02168  538 AIEAALGGRLQAVvvENLNAAKkaiAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFdpKLRKA 617

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   538 LEEA------KEKGEQAEALEKELHRLE---------------------KENEQLTKEVTSLKAATEKVEALEHQSQGLE 590
Cdd:TIGR02168  618 LSYLlggvlvVDDLDNALELAKKLRPGYrivtldgdlvrpggvitggsaKTNSSILERRREIEELEEKIEELEEKIAELE 697

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   591 LENRSLRKSLDTLQNVSVQLEGLERDK-QQLGQENLELRKMVEAMRFTSAKMAQIETENRQLEREKEELRRDVE----LL 665
Cdd:TIGR02168  698 KALAELRKELEELEEELEQLRKELEELsRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEeaeeEL 777

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   666 KTLSKKSERLELSYQSVSAENLQLQHSLESSTHKSQALQRELSQLEAERQALRRDLE----TLQLTHKQLEGAEEDRKAL 741
Cdd:TIGR02168  778 AEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAaterRLEDLEEQIEELSEDIESL 857

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   742 EQEVAQLEKDK-------KLLEKEARRLWQQVELKDAILDDSAAKLSAAEKESRALDKELARCRDvgsklkELEKDNRDL 814
Cdd:TIGR02168  858 AAEIEELEELIeeleselEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELRE------KLAQLELRL 931

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|
gi 755543021   815 TKQVTMHTRTLTTLREDLVLEKLKSQQLSSELDKLSQELE 854
Cdd:TIGR02168  932 EGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEAR 971
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 385-996 3.20e-21

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 101.55  E-value: 3.20e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  385 RILKLEKENQSLQSTIQGLRDTSLALEESSLKYGELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQS 464
Cdd:COG1196   216 RELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLA 295

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  465 GMEALKADRARQIKDLEQEKGHLHQAvwslrerpqvnstkdvEKENRALHQAVTEAGSKLSQLELEKQQLHRDLEEAKEK 544
Cdd:COG1196   296 ELARLEQDIARLEERRRELEERLEEL----------------EEELAELEEELEELEEELEELEEELEEAEEELEEAEAE 359

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  545 GEQAEALEKELHRLEKENEQLTKEvtslkaatEKVEALEHQSQGLELENRslrksldtLQNVSVQLEGLERDKQQLGQEN 624
Cdd:COG1196   360 LAEAEEALLEAEAELAEAEEELEE--------LAEELLEALRAAAELAAQ--------LEELEEAEEALLERLERLEEEL 423

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  625 LELRKMVEAMRftsakmAQIETENRQLEREKEELRRDVELLKTLSKKSERLELSYQSVSAENLQLQHSLESSTHKSQALQ 704
Cdd:COG1196   424 EELEEALAELE------EEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLL 497

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  705 RELSQLEAERQALRRDLETLQLTHKQLEGAEEDRKALEQEVA-----------QLEKDKKLLEKEARRLWQQVELKDAIL 773
Cdd:COG1196   498 EAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAAleaalaaalqnIVVEDDEVAAAAIEYLKAAKAGRATFL 577

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  774 DDSAAKLSAAEKESRALDKELARCRDVGSKLKELEKDNRDLtkQVTMHTRTLTTLREDLVLEKLKsqqlsseldKLSQEL 853
Cdd:COG1196   578 PLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVL--GDTLLGRTLVAARLEAALRRAV---------TLAGRL 646

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  854 EKVGLSKDLLLQEDDGHGDGKGKTESALKTTLAMKEEKIVFLEAQVEEKESLSRQLQIELQMIKKEHEQLRQTQEGGDKA 933
Cdd:COG1196   647 REVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEAL 726

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755543021  934 QNALKRppgkVTSHQEKEAWEPSHkeatmELLRVKDRAIELERSNAALQAERQLLKEQLQHLE 996
Cdd:COG1196   727 EEQLEA----EREELLEELLEEEE-----LLEEEALEELPEPPDLEELERELERLEREIEALG 780
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 412-1150 3.27e-21

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 101.68  E-value: 3.27e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   412 ESSLKYGELEKENQQ-----LSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEALKADR---ARQIKDLEQE 483
Cdd:TIGR02169  208 EKAERYQALLKEKREyegyeLLKEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLeelNKKIKDLGEE 287

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   484 kghlhqavwslrERPQVNST-KDVEKENRALHQAVTEAGSKLSQLELEKQQLHRDLEEAKEkgeQAEALEKELHRLEKEN 562
Cdd:TIGR02169  288 ------------EQLRVKEKiGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLA---EIEELEREIEEERKRR 352

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   563 EQLTKEVTSLKaatEKVEALEHQSQGLELENRSLRKSLDTLQnvsVQLEGLERDKQQLGQE----NLELRKMVEAMRFTS 638
Cdd:TIGR02169  353 DKLTEEYAELK---EELEDLRAELEEVDKEFAETRDELKDYR---EKLEKLKREINELKREldrlQEELQRLSEELADLN 426

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   639 AKMAQIETENRQLEREKEELRRDVEL----LKTLSKKSERLELSYQSVSAENLQLQHSLESsthksqaLQRELSQLEAER 714
Cdd:TIGR02169  427 AAIAGIEAKINELEEEKEDKALEIKKqewkLEQLAADLSKYEQELYDLKEEYDRVEKELSK-------LQRELAEAEAQA 499

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   715 QALRRDLETLQLTHKQLEgaeEDRKALEQEVAQL----EKDKKLLEKEARRLWQQVELKDAILDDSAAKLSAAEKESRAL 790
Cdd:TIGR02169  500 RASEERVRGGRAVEEVLK---ASIQGVHGTVAQLgsvgERYATAIEVAAGNRLNNVVVEDDAVAKEAIELLKRRKAGRAT 576

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   791 DKELARCRDVGSKLKELEKDN-----------------------------------RDLTKQVTMHT------------- 822
Cdd:TIGR02169  577 FLPLNKMRDERRDLSILSEDGvigfavdlvefdpkyepafkyvfgdtlvvedieaaRRLMGKYRMVTlegelfeksgamt 656

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   823 ---RTLTTLREDLVLEKLKSQQLSSELDKLSQELE----KVGLSKDLLLQEDDGHGDGKGKTESALKTTLAMKEEkivfL 895
Cdd:TIGR02169  657 ggsRAPRGGILFSRSEPAELQRLRERLEGLKRELSslqsELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQE----E 732

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   896 EAQVEEKESLSRQLQI----------ELQMIKKEHEQLRQTQEGGDKAQNALKRPPgkvtSHQEKEAWEPSHKEATMELL 965
Cdd:TIGR02169  733 EKLKERLEELEEDLSSleqeienvksELKELEARIEELEEDLHKLEEALNDLEARL----SHSRIPEIQAELSKLEEEVS 808

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   966 RVKDRAIELERSNAALQAERQLLKEQLQHLETQNVSFSSQILTLQKQSAFLQEHTTTLQTQTAKLQVENSTLSSQNAALS 1045
Cdd:TIGR02169  809 RIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLK 888

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1046 -------AQYTVLQSQQAAKEAEHEGLQQQQEQLAAVYEALLQDHKHLGTLYECQSSEYEALIRQHSCLKTLHRnLELEH 1118
Cdd:TIGR02169  889 kerdeleAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEEELSLEDVQAELQR-VEEEI 967

                          810       820       830
                   ....*....|....*....|....*....|....*....
gi 755543021  1119 KELG-------ERHGDLQQRKAELEELEKVLSTEREALE 1150
Cdd:TIGR02169  968 RALEpvnmlaiQEYEEVLKRLDELKEKRAKLEEERKAIL 1006
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 288-910 3.66e-20

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 98.09  E-value: 3.66e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  288 EEQLTASRAR----SDKVHELEKenlQLKSklhdleLDRDADKKqiekllEEYMVLEMAQKQsmKESAHLGWELEQLSKN 363
Cdd:COG1196   178 ERKLEATEENlerlEDILGELER---QLEP------LERQAEKA------ERYRELKEELKE--LEAELLLLKLRELEAE 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  364 ADLSDASRKSfvfelnecASSRILKLEKENQSLQSTIQGLRdtsLALEESSLKYGELEKENQQLSKKIEKLQTQLEREKQ 443
Cdd:COG1196   241 LEELEAELEE--------LEAELEELEAELAELEAELEELR---LELEELELELEEAQAEEYELLAELARLEQDIARLEE 309

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  444 SNQDLETLSEELIREKEQLQSGMEALKADRARQIKDLEQEKGHLHQAVWSLRErpqvnSTKDVEKENRALHQAVTEAGSK 523
Cdd:COG1196   310 RRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAE-----AEEALLEAEAELAEAEEELEEL 384

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  524 LSQLELEKQQLHRDLEEAKEKGEQAEALEKELHRLEKE----NEQLTKEVTSLKAATEKVEALEHQSQGLELENRSLRKS 599
Cdd:COG1196   385 AEELLEALRAAAELAAQLEELEEAEEALLERLERLEEEleelEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLEL 464

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  600 LDTLQNVSVQLEGLERDKQQLGQENLELRKMVEAMR------FTSAKMAQIETENRQLEREKEELRRDVELLKTLSKKSE 673
Cdd:COG1196   465 LAELLEEAALLEAALAELLEELAEAAARLLLLLEAEadyegfLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAAL 544

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  674 RLELSYQSVSAENLQLQHSLESSTHKSQALQRELSQLEAERQALRRDLETLQLTHKQLEGAEEDRKALE----------- 742
Cdd:COG1196   545 AAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADAryyvlgdtllg 624

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  743 --QEVAQLEKDKKLLEKEARRLWQQVELKDAILDDSAAKLSAAEKESRALDKELARCRDVGSKLKELEKDNRDLTKQVTM 820
Cdd:COG1196   625 rtLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEE 704

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  821 HTRTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLSKDLLLQEDDGHGDGKGKTESALKTTLAMKEEKIVFL----- 895
Cdd:COG1196   705 EERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEALgpvnl 784

                         650       660
                  ....*....|....*....|.
gi 755543021  896 ------EAQVEEKESLSRQLQ 910
Cdd:COG1196   785 laieeyEELEERYDFLSEQRE 805
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
176-756 3.73e-20

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 97.83  E-value: 3.73e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  176 ELADTKARLRRVRQELEEKTEQLADTRHEVDQLVLELqkakqdnIQLAADARSARAYRDELDSLREKANRVERLEMDLVR 255
Cdd:PRK03918  180 RLEKFIKRTENIEELIKEKEKELEEVLREINEISSEL-------PELREELEKLEKEVKELEELKEEIEELEKELESLEG 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  256 CKEKLhdvdfyKARMEELREDniilIETKAMLEEQLTASRARSDKVHELEKENLQLKsKLHDLELDRdadKKQIEKLLEE 335
Cdd:PRK03918  253 SKRKL------EEKIRELEER----IEELKKEIEELEEKVKELKELKEKAEEYIKLS-EFYEEYLDE---LREIEKRLSR 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  336 YMVLEMAQKQSMKESAHLGWELEQLSKnaDLSDASRKSFVFELNECASSRILKLEKENQSLQStiqglRDTSLALEESSL 415
Cdd:PRK03918  319 LEEEINGIEERIKELEEKEERLEELKK--KLKELEKRLEELEERHELYEEAKAKKEELERLKK-----RLTGLTPEKLEK 391

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  416 KYGELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREK--------EQLQSGMEALKADRARQIKDLEQEKGHL 487
Cdd:PRK03918  392 ELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKgkcpvcgrELTEEHRKELLEEYTAELKRIEKELKEI 471

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  488 HQAVWSLRER-PQVNSTKDVEKENRALHQAVTEAgsklsqLELEKQQLHRDLEEAKEKGEQAEALEKELHRLEKENEQLT 566
Cdd:PRK03918  472 EEKERKLRKElRELEKVLKKESELIKLKELAEQL------KELEEKLKKYNLEELEKKAEEYEKLKEKLIKLKGEIKSLK 545

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  567 KEVTSLKAATEKVEALEHQSQGLELENRSLRKSLDTLQNVSVqlEGLERDKQQLGQENLELRKMVEAMRFTSAKMAQIET 646
Cdd:PRK03918  546 KELEKLEELKKKLAELEKKLDELEEELAELLKELEELGFESV--EELEERLKELEPFYNEYLELKDAEKELEREEKELKK 623

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  647 ENRQLEREKEELRRDVELLKTLSKKSERLELSYQSVSAENLQlqhslesstHKSQALQRELSQLEAERQALRRDLETLQL 726
Cdd:PRK03918  624 LEEELDKAFEELAETEKRLEELRKELEELEKKYSEEEYEELR---------EEYLELSRELAGLRAELEELEKRREEIKK 694

                         570       580       590
                  ....*....|....*....|....*....|
gi 755543021  727 THKQLEGAEEDRKALEQEVAQLEKDKKLLE 756
Cdd:PRK03918  695 TLEKLKEELEEREKAKKELEKLEKALERVE 724
HkD_Girdin cd22229
Hook domain found in Girdin and similar proteins; Girdin, also called Akt phosphorylation ...
 38-85 6.13e-20

Hook domain found in Girdin and similar proteins; Girdin, also called Akt phosphorylation enhancer (APE), or coiled-coil domain-containing protein 88A (CCDC88A), or G alpha-interacting vesicle-associated protein (GIV), or Girders of actin filament, or Hook-related protein 1 (HkRP1), is a bifunctional modulator of guanine nucleotide-binding proteins (G proteins). It acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits. It also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS. In addition, Girdin plays an essential role in cell migration.


Pssm-ID: 411800  Cd Length: 156  Bit Score: 88.31  E-value: 6.13e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 755543021   38 MEEIKKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEVTH 85
Cdd:cd22229   109 TEEMKKLLLLLLGCAVQCERKEEFIERIQTLDFDTKAAVAAHIQEVTH 156
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 609-1218 3.03e-19

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 95.00  E-value: 3.03e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  609 QLEGLERDK------QQLgQENLELRKMVEAMRFTSAKMAQIETENRQLEREKEELRRDVELLKTLSKKSERLELSYQSV 682
Cdd:COG1196   201 QLEPLERQAekaeryREL-KEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEEL 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  683 SAENLQLQHSLESSTHKSQALQRELSQLEAERQALRRDLETLQLthkQLEGAEEDRKALEQEVAQLEKDKKLLEKEARRL 762
Cdd:COG1196   280 ELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEE---ELAELEEELEELEEELEELEEELEEAEEELEEA 356

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  763 WQQVELKDAILDDSAAKLSAAEKESRALDKELARCRdvgSKLKELEKDNRDLTKQVTMHTRTLTTLREDLVLEKLKSQQL 842
Cdd:COG1196   357 EAELAEAEEALLEAEAELAEAEEELEELAEELLEAL---RAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAEL 433

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  843 SSELDKLSQELEKVGLSKDLLLQEddghgdgkgktESALKTTLAMKEEKIVFLEAQVEEKESLSRQLQIELQMIKKEHEQ 922
Cdd:COG1196   434 EEEEEEEEEALEEAAEEEAELEEE-----------EEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEAD 502

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  923 LRQTQEGGdKAQNALKRPPGKVTSHQEKEAWEPSHKEATMELLRVKDRAIELERSNAALQAERQLLKEQLQHLETQnvsf 1002
Cdd:COG1196   503 YEGFLEGV-KAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATFL---- 577

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1003 ssqILTLQKQSAFLQEHTTTLQTQTAKLQVEnstlsSQNAALSAQYTVLQSQQAAKEAEHEGLqqqqeqLAAVYEALLQD 1082
Cdd:COG1196   578 ---PLDKIRARAALAAALARGAIGAAVDLVA-----SDLREADARYYVLGDTLLGRTLVAARL------EAALRRAVTLA 643

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1083 HKHLGTLYECQSSEYEALIRQHSCLKTLHRNLELEHKELGERHGDLQQRKAELEELEKVLSTEREALEREQKTNAIATSE 1162
Cdd:COG1196   644 GRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEE 723

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 755543021 1163 NQRLRGELDRISFLHQQLKGEYEELHAHTKELKTSLnnsqLELSRWQVRFDELKEQ 1218
Cdd:COG1196   724 EALEEQLEAEREELLEELLEEEELLEEEALEELPEP----PDLEELERELERLERE 775
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 416-938 4.59e-19

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 93.93  E-value: 4.59e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   416 KYGELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEALKADRA---RQIKDLEQEKGHLHQAVW 492
Cdd:TIGR04523  125 ELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLniqKNIDKIKNKLLKLELLLS 204

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   493 SLRERPQVNST-----KDVEKENRALHQAVTEAGSKLSQLELE----KQQLHRDLEEAKEKGEQAEALEKELHRLEKENE 563
Cdd:TIGR04523  205 NLKKKIQKNKSlesqiSELKKQNNQLKDNIEKKQQEINEKTTEisntQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIK 284

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   564 QLTKEVTSLKAateKVEALEHQSQ-----GLELENRSLRKSLDTLQN-----------VSVQLEGLERDKQQLGQENLEL 627
Cdd:TIGR04523  285 ELEKQLNQLKS---EISDLNNQKEqdwnkELKSELKNQEKKLEEIQNqisqnnkiisqLNEQISQLKKELTNSESENSEK 361

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   628 RKmveamrftsakmaQIETENRQLEREKEELRRDVELLKTLSKKSERLELSYQSVSAENLQLQHSLESsthksqaLQREL 707
Cdd:TIGR04523  362 QR-------------ELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKK-------LQQEK 421

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   708 SQLEAERQALRRDLETLQLTHKQLEGAEEDR----KALEQEVAQLEKDKKLLEKEARRLWQQVELKDAILDDSAAKLSAA 783
Cdd:TIGR04523  422 ELLEKEIERLKETIIKNNSEIKDLTNQDSVKeliiKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKL 501

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   784 EKESRALDKELArcrDVGSKLKELEKDNRDLTKQVTMHTRTLTTLREDLVLEK--LKSQQLSSELDKLSQELEKVGLSKD 861
Cdd:TIGR04523  502 NEEKKELEEKVK---DLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKDDfeLKKENLEKEIDEKNKEIEELKQTQK 578

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755543021   862 LLLqeddghgdgkgKTESALKTTLAMKEEKIVFLEAQVEEKESLSRQLQIELQMIKKEHEQLRQTQEGGDKAQNALK 938
Cdd:TIGR04523  579 SLK-----------KKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLK 644
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 168-1231 1.12e-18

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 93.32  E-value: 1.12e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   168 EDKQHLAVELADTKARLRRVRQELEEKTEQLADTRHEVDQLVLELQKAKqdniQLAADARSARAyrdeldslrEKANRVE 247
Cdd:pfam01576    5 EEMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQAET----ELCAEAEEMRA---------RLAARKQ 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   248 RLEmdlvrckEKLHDVDfykARMEELREDNIIL-IETKAM------LEEQLTASRARSDKVHeLEKENLQLKSKLHD--- 317
Cdd:pfam01576   72 ELE-------EILHELE---SRLEEEEERSQQLqNEKKKMqqhiqdLEEQLDEEEAARQKLQ-LEKVTTEAKIKKLEedi 140

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   318 LELDRDADKKQIEKLLEEYMVLEMaqkqsmkeSAHLGWElEQLSKNADLSDASRKSFVFELNEcassRILKLEKENQSLQ 397
Cdd:pfam01576  141 LLLEDQNSKLSKERKLLEERISEF--------TSNLAEE-EEKAKSLSKLKNKHEAMISDLEE----RLKKEEKGRQELE 207

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   398 STIQGLRDTSLALEESSLKY-GELEKENQQLSKKIEKLQTQLER-EKQSNQDLETLSE--ELIREKEQLQSGMEALKADR 473
Cdd:pfam01576  208 KAKRKLEGESTDLQEQIAELqAQIAELRAQLAKKEEELQAALARlEEETAQKNNALKKirELEAQISELQEDLESERAAR 287

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   474 AR---QIKDLEQE----KGHL---------HQAVWSLRERPQVNSTKDVEKENRALHQAVTEAGSKLSQLelekqqlhrd 537
Cdd:pfam01576  288 NKaekQRRDLGEElealKTELedtldttaaQQELRSKREQEVTELKKALEEETRSHEAQLQEMRQKHTQA---------- 357

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   538 LEEAKEKGEQAE----ALEKELHRLEKENEQLTKEVTSLKAATEKVealEHQSQGLELEnrslrksldtLQNVSVQLEGL 613
Cdd:pfam01576  358 LEELTEQLEQAKrnkaNLEKAKQALESENAELQAELRTLQQAKQDS---EHKRKKLEGQ----------LQELQARLSES 424

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   614 ERDKQQLGQENLELRKMVEAMrftSAKMAQIETENRQLEREKEELRRDVELLKTLSKKSERLELSYQS----VSAENLQL 689
Cdd:pfam01576  425 ERQRAELAEKLSKLQSELESV---SSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQEETRQKLNLSTrlrqLEDERNSL 501

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   690 QHSLESSTHKSQALQRELSQLEAERQALRRDLETLQLThkqLEGAEEDRKALEQEVAQL-------EKDKKLLEKEARRL 762
Cdd:pfam01576  502 QEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDAGT---LEALEEGKKRLQRELEALtqqleekAAAYDKLEKTKNRL 578

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   763 WQQVELKDAILDDSAAKLSAAEKESRALDKELARCRDVGSKLKE---------LEKDNRDLT------------KQVTMH 821
Cdd:pfam01576  579 QQELDDLLVDLDHQRQLVSNLEKKQKKFDQMLAEEKAISARYAEerdraeaeaREKETRALSlaraleealeakEELERT 658

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   822 TRTLTTLREDLVLEKLKSQQLSSELDK----LSQELEKVGLSKDLLLQEDDGHGDGKGKTESALKTTLAMKEEKIVFLEA 897
Cdd:pfam01576  659 NKQLRAEMEDLVSSKDDVGKNVHELERskraLEQQVEEMKTQLEELEDELQATEDAKLRLEVNMQALKAQFERDLQARDE 738

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   898 QVEEK-ESLSRQLQIELQMIKKEHEQLRQTQEGGDKAQNALKRPPGKVtshqekEAWEPSHKEATMELLRVKDRAIELER 976
Cdd:pfam01576  739 QGEEKrRQLVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQI------DAANKGREEAVKQLKKLQAQMKDLQR 812

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   977 SNAALQAERQLLKEQLQHLETQNVSFSSQILTLQKQSAFLQEHTTTLQTQTAKLQVENSTLSSQNAALSAQYTVLQSQQA 1056
Cdd:pfam01576  813 ELEEARASRDEILAQSKESEKKLKNLEAELLQLQEDLAASERARRQAQQERDELADEIASGASGKSALQDEKRRLEARIA 892

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1057 AKEAEHEGLQQQQEQLAAVYEALLQDHKHLGTLYecqSSEYEALIRQHSCLKTLHR-NLELEHKeLGERHGDLQQR-KAE 1134
Cdd:pfam01576  893 QLEEELEEEQSNTELLNDRLRKSTLQVEQLTTEL---AAERSTSQKSESARQQLERqNKELKAK-LQEMEGTVKSKfKSS 968

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1135 LEELEKVLSTEREALEREQKTNAIATSENQRLRGELDRISFL-------HQQLKGEYEELHAHTKELKTSLNNSQLELSR 1207
Cdd:pfam01576  969 IAALEAKIAQLEEQLEQESRERQAANKLVRRTEKKLKEVLLQvederrhADQYKDQAEKGNSRMKQLKRQLEEAEEEASR 1048

                         1130      1140      1150
                   ....*....|....*....|....*....|.
gi 755543021  1208 -------WQVRFDELKEQHQSMDISLTKMDN 1231
Cdd:pfam01576 1049 anaarrkLQRELDDATESNESMNREVSTLKS 1079
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 169-797 7.80e-18

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 90.51  E-value: 7.80e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   169 DKQHLAVELADTKARLRRVRQELEEKTEQLADTRHEVDQLVLELQKAKQDNIQLaadarsARAYRDELDSLREKANRVER 248
Cdd:TIGR02169  351 RRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINEL------KRELDRLQEELQRLSEELAD 424

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   249 LEMDLVRCKEKLHDVD-FYKARMEELREDNIILIETKAMLEEQLTASRARSDKVHELEKENLQLKSKLHDLELDRDADKK 327
Cdd:TIGR02169  425 LNAAIAGIEAKINELEeEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEE 504

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   328 QIEKLLEEYMVLEMAQKQSMKESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTI------- 400
Cdd:TIGR02169  505 RVRGGRAVEEVLKASIQGVHGTVAQLGSVGERYATAIEVAAGNRLNNVVVEDDAVAKEAIELLKRRKAGRATFlplnkmr 584

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   401 QGLRDTSLALEESSLKYG----ELEKENQQLSKKI-------EKLQTQleREKQSNQDLETLSEELI------------- 456
Cdd:TIGR02169  585 DERRDLSILSEDGVIGFAvdlvEFDPKYEPAFKYVfgdtlvvEDIEAA--RRLMGKYRMVTLEGELFeksgamtggsrap 662

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   457 --------REKEQLQS---GMEALKADRARQIKDLEQEKGHLHQAVWSLRERPQvnSTKDVEKENRALHQAVTEAGSKLS 525
Cdd:TIGR02169  663 rggilfsrSEPAELQRlreRLEGLKRELSSLQSELRRIENRLDELSQELSDASR--KIGEIEKEIEQLEQEEEKLKERLE 740

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   526 QLELEKQQLHRDLEEAKEKgeqAEALEKELHRLEKENEQLTKEVTSLKA--ATEKVEALEHQSQGLELENRSLRKSLDT- 602
Cdd:TIGR02169  741 ELEEDLSSLEQEIENVKSE---LKELEARIEELEEDLHKLEEALNDLEArlSHSRIPEIQAELSKLEEEVSRIEARLREi 817

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   603 ---LQNVSVQLEGLERDKQQLGQENLEL---RKMVEA--------MRFTSAKMAQIETENRQLEREKEELRRDVELLKtl 668
Cdd:TIGR02169  818 eqkLNRLTLEKEYLEKEIQELQEQRIDLkeqIKSIEKeienlngkKEELEEELEELEAALRDLESRLGDLKKERDELE-- 895

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   669 sKKSERLELSYQSVSAENLQLQHSLESSTHKSQALQRELSQLEAERQALRRDLETLQlthkQLEGAEEDRKALEQEVAQL 748
Cdd:TIGR02169  896 -AQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEEEL----SLEDVQAELQRVEEEIRAL 970

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*....
gi 755543021   749 EKDKKLLEkearrlwQQVELKDAILDDSAAKLSAAEKESRALDKELARC 797
Cdd:TIGR02169  971 EPVNMLAI-------QEYEEVLKRLDELKEKRAKLEEERKAILERIEEY 1012
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 298-1033 1.51e-17

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 89.41  E-value: 1.51e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   298 SDKVHELEKENLQ-----LKSKLHDLELDRDA--DKKQIEKLLEEYMvlemaqKQSMKESAHlgwELEqlsknadlsdaS 370
Cdd:pfam15921   97 SNELHEKQKFYLRqsvidLQTKLQEMQMERDAmaDIRRRESQSQEDL------RNQLQNTVH---ELE-----------A 156

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   371 RKSFVFELNECASSRILKLEKENQSLQSTIQGLRDTSLALEESSLK-----------------------YGELEKENQQL 427
Cdd:pfam15921  157 AKCLKEDMLEDSNTQIEQLRKMMLSHEGVLQEIRSILVDFEEASGKkiyehdsmstmhfrslgsaiskiLRELDTEISYL 236

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   428 SKKIEKLQTQLEREKQSNQDletlSEELIRekEQLQSGMEALKADRARQIKDLEQEKGHLHQAVWSLRERPQVnSTKDVE 507
Cdd:pfam15921  237 KGRIFPVEDQLEALKSESQN----KIELLL--QQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQLEI-IQEQAR 309

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   508 KENRALHQAVTEAGSKLSQLELEKQQLHRDLEEAKEKGEQAEAL-EKELHRLEKENEQLTKEVTSLKAATEKVEA-LEHQ 585
Cdd:pfam15921  310 NQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKIEELEKQLVLaNSELTEARTERDQFSQESGNLDDQLQKLLAdLHKR 389

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   586 SQGLELENRSLRKSLDTLQNVSVQLEGLERDKQQLGQENLELRKMVEAMRF-----TSAKMAQIETENR----------Q 650
Cdd:pfam15921  390 EKELSLEKEQNKRLWDRDTGNSITIDHLRRELDDRNMEVQRLEALLKAMKSecqgqMERQMAAIQGKNEslekvssltaQ 469

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   651 LEREKEELRRDVEllkTLSKKSERLELSYQSVSaenlQLQHSLESSTHKSQALQRELSQLEAerqalRRDLETLQLTHKQ 730
Cdd:pfam15921  470 LESTKEMLRKVVE---ELTAKKMTLESSERTVS----DLTASLQEKERAIEATNAEITKLRS-----RVDLKLQELQHLK 537

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   731 LEGAEEDRKALEQEVAQLEKDKKllEKEARRLWQQVELKDAILDDSAAKLSAAEKESRALDKELarcRDVGSKLKELE-- 808
Cdd:pfam15921  538 NEGDHLRNVQTECEALKLQMAEK--DKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEI---NDRRLELQEFKil 612

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   809 KDNRDltkqvtMHTRTLTTLREDLVLEKLKSQQLSSELDKLSQELEKvglSKDLLLQEddghgdgkgkTESALKTTLAMK 888
Cdd:pfam15921  613 KDKKD------AKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQ---ERDQLLNE----------VKTSRNELNSLS 673

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   889 EEKIVF---LEAQVEEKESLSRQLQIELQMIKKEHEQLRQT---QEGGDKaqNALkrppgKVTSHQEKEAwepSHKEATM 962
Cdd:pfam15921  674 EDYEVLkrnFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTlksMEGSDG--HAM-----KVAMGMQKQI---TAKRGQI 743

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755543021   963 ELLRVKDRAIELERSNAA-----LQAERQLLKEQLQHLETQNVSFSSQILTLQKQSAFLQEHTTTLQTQTAKLQVE 1033
Cdd:pfam15921  744 DALQSKIQFLEEAMTNANkekhfLKEEKNKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVANMEVALDKASLQ 819
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 522-1350 1.52e-17

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 89.74  E-value: 1.52e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   522 SKLSQLELEKQQLHRDLEEAKEKGEQAEALEKE----LHRLEKENEQLTKeVTSLKAATEKVEALEHQSQGLELEnRSLR 597
Cdd:TIGR02169  163 AGVAEFDRKKEKALEELEEVEENIERLDLIIDEkrqqLERLRREREKAER-YQALLKEKREYEGYELLKEKEALE-RQKE 240

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   598 KSLDTLQNVSVQLEGLERDKQQLGQENLELRKMVEA-----MRFTSAKMAQIETENRQLEREKEELRRDVEL----LKTL 668
Cdd:TIGR02169  241 AIERQLASLEEELEKLTEEISELEKRLEEIEQLLEElnkkiKDLGEEEQLRVKEKIGELEAEIASLERSIAEkereLEDA 320

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   669 SKKSERLELSYQSVSAENLQLQHSLESSTHKSQALQRELSQLEAERQALRRDLETLQLTHKQLEgaeEDRKALEQEVAQL 748
Cdd:TIGR02169  321 EERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETR---DELKDYREKLEKL 397

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   749 EKDKKLLEKEARRLWQQVELKDAILDDSAAKLSAAEkesraldkelarcrdvgSKLKELEKDNRDLTKQVTMHTRTLTTL 828
Cdd:TIGR02169  398 KREINELKRELDRLQEELQRLSEELADLNAAIAGIE-----------------AKINELEEEKEDKALEIKKQEWKLEQL 460

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   829 REDLVLEKLKSQQLSSELDKLSQELEKvgLSKDLllqeddghgdgkgkteSALKTTLAMKEEKIVFLEAQVEEKESlsrq 908
Cdd:TIGR02169  461 AADLSKYEQELYDLKEEYDRVEKELSK--LQREL----------------AEAEAQARASEERVRGGRAVEEVLKA---- 518

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   909 lqielqMIKKEHEQLRQTQEGGDKAQNALKRPPGkvtshqekeawepshkeATMELLRVKD-----RAIELERSNAA--- 980
Cdd:TIGR02169  519 ------SIQGVHGTVAQLGSVGERYATAIEVAAG-----------------NRLNNVVVEDdavakEAIELLKRRKAgra 575

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   981 ----LQAERQLLKEQLQHLETQNVSFSSQILTLQKQ--SAFLQEHTTTLQTQ---TAKLQVENSTLSSQNAAL------- 1044
Cdd:TIGR02169  576 tflpLNKMRDERRDLSILSEDGVIGFAVDLVEFDPKyePAFKYVFGDTLVVEdieAARRLMGKYRMVTLEGELfeksgam 655

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1045 ---SAQYTVLQSQQAAKEAEHEGLQQQQEQLAAVYEALLQDHKHLGTLYECQSSEYEALIRQHsclktlhRNLELEHKEL 1121
Cdd:TIGR02169  656 tggSRAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKI-------GEIEKEIEQL 728

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1122 GERHGDLQQRKAELEELEKVLSTEREALEREQKTNAiatsenqrlrgelDRISFLHQQLKGEYEELhahtKELKTSLNNS 1201
Cdd:TIGR02169  729 EQEEEKLKERLEELEEDLSSLEQEIENVKSELKELE-------------ARIEELEEDLHKLEEAL----NDLEARLSHS 791

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1202 QLELSRWQVRfdELKEQHQSMDISLTKMDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQ---------NMESK 1272
Cdd:TIGR02169  792 RIPEIQAELS--KLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEienlngkkeELEEE 869

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755543021  1273 EQYHE-EQKQYIDKLNALRRHKEKLEEKIMDQYKFYDPAPKKKNHwigAKALVKLIKPKKEGSRERLKSTTDSPPWQLE 1350
Cdd:TIGR02169  870 LEELEaALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEK---KRKRLSELKAKLEALEEELSEIEDPKGEDEE 945
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 518-1339 5.46e-17

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 87.72  E-value: 5.46e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   518 TEAGSKLSQLELEKQQLHRDLEEAK--EKGEQAEALEKELHRLEKENEQLTKEVTSLKAATEKVEALEHQSQGLELENRS 595
Cdd:pfam02463  172 KEALKKLIEETENLAELIIDLEELKlqELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRDEQE 251

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   596 LRKSLDTLQNVSvqLEGLERDKQQLGQENLELRKMVEAMRFTSAKMAQIETENRQLEREKEELRRDVELLKtlsKKSERL 675
Cdd:pfam02463  252 EIESSKQEIEKE--EEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESE---KEKKKA 326

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   676 ELSYQSVSAENLQLQHSLESSTHKSQALQRELSQLEAERQALRRDLETLQLTHKQL-EGAEEDRKALEQEVAQLEKDKKL 754
Cdd:pfam02463  327 EKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLEsERLSSAAKLKEEELELKSEEEKE 406

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   755 LEKEARRLWQQVELKDAILDDSAAKLSAAEKESRALDKELARCRDVGSKLKELEKDNRD---------LTKQVTMHTRTL 825
Cdd:pfam02463  407 AQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELelkksedllKETQLVKLQEQL 486

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   826 TTLREDLVLEKLKSQQLSSELDKLSQELEKVGLSKDLLLQEDDGHGDGKGKTESALKTTLAMKEEKIVFLEAQVEEKESL 905
Cdd:pfam02463  487 ELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEERQKL 566

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   906 SRQLQIELQMIKKEHEQLRQTQEGGDKAQNALKRPPGKVTSHQEKEAWEPSHKEATMELLRVKDRAIELERSNAALQAER 985
Cdd:pfam02463  567 VRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKESAKAKES 646

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   986 QLLK-EQLQHLETQNVSFSSQILTLQKQSAFLQEHTTTLQTQTAKLQVENSTLSSQNAALSAQYTVLQSQQAAKEAEHEG 1064
Cdd:pfam02463  647 GLRKgVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAEELLADR 726

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1065 LQQQQEQLAAVYEALLQDHKHLGTLYECQSSEYEALIRQHSCLKTLHRNLELEHKELGERHGDLQQRKAELEELEKVLST 1144
Cdd:pfam02463  727 VQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRAL 806

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1145 EREALEREQKTNAIATSENQRLRGELDRISFLHQQLKGEYEELHAHTKELKTSLNNSQLELSRWQVrfDELKEQHQSMDI 1224
Cdd:pfam02463  807 EEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELLQEL--LLKEEELEEQKL 884

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1225 SLTKMDNHCELLSRLKGNLEEENH--HLLSQIQLLSQQNQMLLEQNMESKEQYHEEQKQYIDKLNALRRHKEKLEEKIMD 1302
Cdd:pfam02463  885 KDELESKEEKEKEEKKELEEESQKlnLLEEKENEIEERIKEEAEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKR 964

                          810       820       830
                   ....*....|....*....|....*....|....*..
gi 755543021  1303 QYKFYDPAPKKKNHWIGAKALVKLIKPKKEGSRERLK 1339
Cdd:pfam02463  965 LLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLE 1001
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 104-857 5.53e-17

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 87.80  E-value: 5.53e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   104 EELEALSRNM-VFHLRRLIDERDECTELIVDLTQERDYLQTQQPPSPGKFSSPDSTPSPTSSLSSE----------DKQH 172
Cdd:TIGR02168  220 AELRELELALlVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEElqkelyalanEISR 299

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   173 LAVELADTKARLRRVRQELEEKTEQLADTRHEVDQLVLELQKAKQDNIQLAAdarsarayrdELDSLREKANRVERLEMD 252
Cdd:TIGR02168  300 LEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKE----------ELESLEAELEELEAELEE 369

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   253 LvrckeklhdvdfyKARMEELRedniilietkamlEEQLTASRARSDKVHELEKENLQ---LKSKLHDLELDRDADKKQI 329
Cdd:TIGR02168  370 L-------------ESRLEELE-------------EQLETLRSKVAQLELQIASLNNEierLEARLERLEDRRERLQQEI 423

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   330 EKLLEEYMVLEMAQKQSmkESAHLGWELEQLSKNADLSDASRKSFVFELNEcASSRILKLEKENQSLQSTIQGLRDTSLA 409
Cdd:TIGR02168  424 EELLKKLEEAELKELQA--ELEELEEELEELQEELERLEEALEELREELEE-AEQALDAAERELAQLQARLDSLERLQEN 500

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   410 LEESSLKYGELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEE-----LIREKEQLQSGMEALK-------------- 470
Cdd:TIGR02168  501 LEGFSEGVKALLKNQSGLSGILGVLSELISVDEGYEAAIEAALGGrlqavVVENLNAAKKAIAFLKqnelgrvtflplds 580

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   471 ----ADRARQIKDLEQEKGHLHQAVWSLRERPQVNSTKD--------VEKENRALHQA---------VTEAG-------- 521
Cdd:TIGR02168  581 ikgtEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSyllggvlvVDDLDNALELAkklrpgyriVTLDGdlvrpggv 660

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   522 -----SKLSQLELEKQQLHRDLEEAKEKGE-QAEALEKELHRLEKENEQLTKEVTSLKAatekvealehQSQGLELENRS 595
Cdd:TIGR02168  661 itggsAKTNSSILERRREIEELEEKIEELEeKIAELEKALAELRKELEELEEELEQLRK----------ELEELSRQISA 730

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   596 LRKSLDTLQNVSVQLEglerdkQQLGQENLELRKMVEAMRFTSAKMAQIETENRQLEREKEELRRDV----ELLKTLSKK 671
Cdd:TIGR02168  731 LRKDLARLEAEVEQLE------ERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIeqlkEELKALREA 804

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   672 SERLELSYQSVSAENLQLQHSLESSTHKSQALQRELSQLEAERQALRRDLETLQlthKQLEGAEEDRKALEQEVAQLEKD 751
Cdd:TIGR02168  805 LDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLA---AEIEELEELIEELESELEALLNE 881

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   752 KKLLEKEARRLWQQVELKDAILDDSAAKLSAAEKESRALDKELArcrDVGSKLKELEKDNRDLTKQVTMHTRtlTTLRED 831
Cdd:TIGR02168  882 RASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLA---QLELRLEGLEVRIDNLQERLSEEYS--LTLEEA 956

                          810       820
                   ....*....|....*....|....*....
gi 755543021   832 LVLE---KLKSQQLSSELDKLSQELEKVG 857
Cdd:TIGR02168  957 EALEnkiEDDEEEARRRLKRLENKIKELG 985
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 239-946 1.18e-16

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 86.31  E-value: 1.18e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   239 LREKANRVERLEMDLVRCKEKLHDVDFYKARM-----EELREDNIILIETKA------MLEEQLTASRARSDKVHELEKE 307
Cdd:pfam05483  101 LKQKENKLQENRKIIEAQRKAIQELQFENEKVslkleEEIQENKDLIKENNAtrhlcnLLKETCARSAEKTKKYEYEREE 180

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   308 NLQLKSKLHDleldrdadkkQIEKLLEEYMVLEMaQKQSMKESAHLGWElEQLSKNADLSDASRKSFVFELNECASSRIL 387
Cdd:pfam05483  181 TRQVYMDLNN----------NIEKMILAFEELRV-QAENARLEMHFKLK-EDHEKIQHLEEEYKKEINDKEKQVSLLLIQ 248

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   388 KLEKENQslqstiqgLRDTSLALEESSLKYGELEkenqqlskkiEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGME 467
Cdd:pfam05483  249 ITEKENK--------MKDLTFLLEESRDKANQLE----------EKTKLQDENLKELIEKKDHLTKELEDIKMSLQRSMS 310

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   468 ALKAdrarqikdLEQEKGHLHQAVWSLRERPQVNsTKDVEKENRALHQAVTEAGSKLSQLElekqQLHRDLEEAKEKGE- 546
Cdd:pfam05483  311 TQKA--------LEEDLQIATKTICQLTEEKEAQ-MEELNKAKAAHSFVVTEFEATTCSLE----ELLRTEQQRLEKNEd 377

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   547 QAEALEKELHRLEKENEQLTKEVTSLKAATEKVEALEHQSQGLELENRSLRKSLDTLQNVSVQLEGLERDKQQlgqENLE 626
Cdd:pfam05483  378 QLKIITMELQKKSSELEEMTKFKNNKEVELEELKKILAEDEKLLDEKKQFEKIAEELKGKEQELIFLLQAREK---EIHD 454

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   627 LRKMVEAMRfTSAKMAQIETENRQLEREKEELRrDVELLKTLSKKSERLELSYQSVSAENLQLQHSLESSTHKSQALQRE 706
Cdd:pfam05483  455 LEIQLTAIK-TSEEHYLKEVEDLKTELEKEKLK-NIELTAHCDKLLLENKELTQEASDMTLELKKHQEDIINCKKQEERM 532

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   707 LSQ---LEAERQALRRDLETLQLTHKQ--------LEGAEEDRKALEQEVAQLEKDKKLLEKEARRLWQQVELKDAILDD 775
Cdd:pfam05483  533 LKQienLEEKEMNLRDELESVREEFIQkgdevkckLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEE 612

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   776 SAAKLSAAEKESRALDKELARCRDVGSKLK-ELEKDNRDLTKQVTMHTRTLTTLR---EDLVLEKLKSQQLSSELDKLSQ 851
Cdd:pfam05483  613 LHQENKALKKKGSAENKQLNAYEIKVNKLElELASAKQKFEEIIDNYQKEIEDKKiseEKLLEEVEKAKAIADEAVKLQK 692

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   852 ELEKV---GLSKDLLLQEDDGHGDGKGKTEsalkttlamKEEKIVFLEAQVEEKESLSRQLQIELQMIKKEHEQLRQTQE 928
Cdd:pfam05483  693 EIDKRcqhKIAEMVALMEKHKHQYDKIIEE---------RDSELGLYKNKEQEQSSAKAALEIELSNIKAELLSLKKQLE 763

                          730
                   ....*....|....*...
gi 755543021   929 GGDKAQNALKRPPGKVTS 946
Cdd:pfam05483  764 IEKEEKEKLKMEAKENTA 781
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 428-1164 1.85e-15

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 82.46  E-value: 1.85e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   428 SKKIEKLQTQLEREKQSNQDLETLSEELIREKE-QLQSGMEALKADRaRQIKDLEQEKGHLhqavwSLRERPQVNSTKDV 506
Cdd:pfam05483   73 SEGLSRLYSKLYKEAEKIKKWKVSIEAELKQKEnKLQENRKIIEAQR-KAIQELQFENEKV-----SLKLEEEIQENKDL 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   507 EKENRA-------LHQAVTEAGSKLSQLELEKQ---QLHRDLEEAKEKgeqaEALEKELHRLEKENEQLTKEVtSLKAAT 576
Cdd:pfam05483  147 IKENNAtrhlcnlLKETCARSAEKTKKYEYEREetrQVYMDLNNNIEK----MILAFEELRVQAENARLEMHF-KLKEDH 221

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   577 EKVEALEHQSQGlELENRSLRKSLDTLQnvSVQLEGLERDKQQLGQENLE-LRKMVEAMRFTSAKMAQIETENRQLEREK 655
Cdd:pfam05483  222 EKIQHLEEEYKK-EINDKEKQVSLLLIQ--ITEKENKMKDLTFLLEESRDkANQLEEKTKLQDENLKELIEKKDHLTKEL 298

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   656 EELRrdVELLKTLSKKsERLELSYQSVSAENLQLQHSLESSTHKSQALQRELSQLEAERQALRRDLETLQLTHKQ-LEGA 734
Cdd:pfam05483  299 EDIK--MSLQRSMSTQ-KALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHSFVVTEFEATTCSLEELLRTEQQrLEKN 375

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   735 EEDRKALEQEV----AQLEKDKKLLEKEARRLwqqVELKDAILDDSaaKLSAAEKESRALDKEL-ARCRDVGSKLKELEK 809
Cdd:pfam05483  376 EDQLKIITMELqkksSELEEMTKFKNNKEVEL---EELKKILAEDE--KLLDEKKQFEKIAEELkGKEQELIFLLQAREK 450

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   810 DNRDLTKQVTM-------HTRTLTTLREDLVLEKLKSQQLSSELDKLSQElekvglSKDLLLQEDDGHGDGKGKTESALK 882
Cdd:pfam05483  451 EIHDLEIQLTAiktseehYLKEVEDLKTELEKEKLKNIELTAHCDKLLLE------NKELTQEASDMTLELKKHQEDIIN 524

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   883 TTlaMKEEKIVfleAQVEEKESLSRQLQIELQMIKKEHEQLR-QTQEGGDKAQNALKRPPGKVTSHQEKEAWEPSHKEAT 961
Cdd:pfam05483  525 CK--KQEERML---KQIENLEEKEMNLRDELESVREEFIQKGdEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNL 599

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   962 MELLRVKDRAIE-LERSNAALQAERQLLKEQLQHLEtqnVSFSSQILTLQKQSAFLQEHTTTLQTQT--AKLQVENSTLS 1038
Cdd:pfam05483  600 KKQIENKNKNIEeLHQENKALKKKGSAENKQLNAYE---IKVNKLELELASAKQKFEEIIDNYQKEIedKKISEEKLLEE 676

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1039 SQNAALSAQYTVLQSQQAAKEAEHEglqqqqeqlAAVYEALLQDHKHlgtlyecqssEYEALIRQHSCLKTLHRNLELEH 1118
Cdd:pfam05483  677 VEKAKAIADEAVKLQKEIDKRCQHK---------IAEMVALMEKHKH----------QYDKIIEERDSELGLYKNKEQEQ 737

                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|
gi 755543021  1119 KEL-GERHGDLQQRKAELEELEKVLSTER---EALEREQKTNAIATSENQ 1164
Cdd:pfam05483  738 SSAkAALEIELSNIKAELLSLKKQLEIEKeekEKLKMEAKENTAILKDKK 787
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 168-658 4.10e-15

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 81.52  E-value: 4.10e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  168 EDKQHLAVELADTKARLRRVRQELEEKTEQLADTRHEVDQLVLELQKAKQDNIQLAADARSARAYRDELDS-----LREK 242
Cdd:COG1196   302 QDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAelaeaEEEL 381

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  243 ANRVERLEMDLVRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTASRARSDKVHELEKENLQLKSKLHDLELDR 322
Cdd:COG1196   382 EELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEAL 461

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  323 DADKKQIEKLLEEYMVLEMAQKQSMKESAHLGWELEQLSKNADLSDASRKSfvfelnecassriLKLEKENQSLQSTIQG 402
Cdd:COG1196   462 LELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKA-------------ALLLAGLRGLAGAVAV 528

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  403 LRDTSLALEESSLKYgELEKENQQLSKKIEKLQTQLEREKQSNQDLET-LSEELIREKEQLQSGMEALKADRARQIKDLE 481
Cdd:COG1196   529 LIGVEAAYEAALEAA-LAAALQNIVVEDDEVAAAAIEYLKAAKAGRATfLPLDKIRARAALAAALARGAIGAAVDLVASD 607

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  482 QEkghLHQAVWSLRERPQVNSTKDVEKENRALHQAVTEAGSKLSQLELEKQQLHRDLEEAKEKGEQAEALEKELHRLEKE 561
Cdd:COG1196   608 LR---EADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEEL 684

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  562 NEQLTKEVTSLKAATEKVEALEHQSQGLELENRSLRKSLDTLQNVSVQLEGLERDKQQlgQENLELRKMVEAMRFTSAKM 641
Cdd:COG1196   685 AERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELL--EEEELLEEEALEELPEPPDL 762

                         490
                  ....*....|....*..
gi 755543021  642 AQIETENRQLEREKEEL 658
Cdd:COG1196   763 EELERELERLEREIEAL 779
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
173-749 9.23e-15

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 80.47  E-value: 9.23e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  173 LAVE--LADTKARLRRVRQELEEKTEQ-----LADTRHEVDQLVLELQKAKQDNIQlaadarsARAYRDELDSLrekanr 245
Cdd:PRK02224  176 LGVErvLSDQRGSLDQLKAQIEEKEEKdlherLNGLESELAELDEEIERYEEQREQ-------ARETRDEADEV------ 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  246 verlemdLVRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLtasRARSDKVHELEKENLQLkskLHDLELDrDAD 325
Cdd:PRK02224  243 -------LEEHEERREELETLEAEIEDLRETIAETEREREELAEEV---RDLRERLEELEEERDDL---LAEAGLD-DAD 308

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  326 KKQIEKLLEEYMVLEMAQKQSMKE-----SAHLGwELEQLSKNADLSDasrksfvfelnecasSRILKLEKENQSLQSTI 400
Cdd:PRK02224  309 AEAVEARREELEDRDEELRDRLEEcrvaaQAHNE-EAESLREDADDLE---------------ERAEELREEAAELESEL 372

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  401 QglrDTSLALEESSLKYGELEKENQQLSKKIEKLQTQLErekqsnqDLETLSEELIREKEQLQSGMEALKADRARQIKDL 480
Cdd:PRK02224  373 E---EAREAVEDRREEIEELEEEIEELRERFGDAPVDLG-------NAEDFLEELREERDELREREAELEATLRTARERV 442

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  481 E-----QEKGHLHQAVWSLRERPQVNSTKDVEkenralhQAVTEAGSKLSQLELEKQQLHRDLEEAKEKGEQAEALEKEL 555
Cdd:PRK02224  443 EeaealLEAGKCPECGQPVEGSPHVETIEEDR-------ERVEELEAELEDLEEEVEEVEERLERAEDLVEAEDRIERLE 515

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  556 HRLEKENEQLTKEVTSLKAATEKVEALEHQSQGLELENRSLRKSLDTL----QNVSVQLEGLERDKQQLGQENLELRKMV 631
Cdd:PRK02224  516 ERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAAEAeeeaEEAREEVAELNSKLAELKERIESLERIR 595

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  632 EAMRFTSAKMAQIETENRQLER--EKEELRRDvellkTLSKKSERLELSYQSVSAENLQ-LQHSLESSTHKSQALQRELS 708
Cdd:PRK02224  596 TLLAAIADAEDEIERLREKREAlaELNDERRE-----RLAEKRERKRELEAEFDEARIEeAREDKERAEEYLEQVEEKLD 670

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|.
gi 755543021  709 QLEAERQALRRD----------LETLQLTHKQLEGAEEDRKALEQEVAQLE 749
Cdd:PRK02224  671 ELREERDDLQAEigaveneleeLEELRERREALENRVEALEALYDEAEELE 721
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 264-1063 9.73e-15

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 80.40  E-value: 9.73e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   264 DFYKARMEELRE-----DNIILIETKAMLEEqltASRARSDKVHELEKENLQLKSKLHDLELDRDAD------KKQIEKL 332
Cdd:pfam02463  166 RLKRKKKEALKKlieetENLAELIIDLEELK---LQELKLKEQAKKALEYYQLKEKLELEEEYLLYLdylklnEERIDLL 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   333 LEEYMVLEMAQKQSMKESAHLGWELEQLSKNADLSDASRKSFVFELNECASsrilKLEKENQSLQSTIQGLRDTSLALEE 412
Cdd:pfam02463  243 QELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAK----EEEELKSELLKLERRKVDDEEKLKE 318

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   413 SSLKYGELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEALKADRARQIKDLEQEKGhLHQAVW 492
Cdd:pfam02463  319 SEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAK-LKEEEL 397

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   493 SLRERPQVNSTKDVEKENRALHQAVTEAGSKLSQLELEKQQLHRDLEEAKEKGEQAEALEKELHRLEKENEQLTKEVTSL 572
Cdd:pfam02463  398 ELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKET 477

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   573 KAATEKVEALEHQSQGLELENRSL----RKSLDTLQNVSVQLEGLERDKQQLGQENLELRKMVEAMRFTSAKMAQIETEN 648
Cdd:pfam02463  478 QLVKLQEQLELLLSRQKLEERSQKeskaRSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATA 557

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   649 RQLEREKEELRRDVELLKTLSKKSERLEL------------------------------------SYQSVSAENLQLQHS 692
Cdd:pfam02463  558 DEVEERQKLVRALTELPLGARKLRLLIPKlklplksiavleidpilnlaqldkatleadeddkraKVVEGILKDTELTKL 637

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   693 LESSTHKSQALQRELSQLEAERQALRRDLETLQLTHKQLEGAEEDRKA--LEQEVAQLEKDKKLLEKEARRLWQQVELKD 770
Cdd:pfam02463  638 KESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAesELAKEEILRRQLEIKKKEQREKEELKKLKL 717

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   771 AILDDSAAKLSAAEKESRALDKELARCRDVGSKlKELEKDNRDLTKQVTMHTRTL--TTLREDLVLEKLKSQQLSSELDK 848
Cdd:pfam02463  718 EAEELLADRVQEAQDKINEELKLLKQKIDEEEE-EEEKSRLKKEEKEEEKSELSLkeKELAEEREKTEKLKVEEEKEEKL 796

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   849 LSQELEKVGLSKDLLLQEDDGHGDGKGKTESalkttLAMKEEKIVFLEAQVEEKESLSRQLQIELQMIKKEHEQLRQTQE 928
Cdd:pfam02463  797 KAQEEELRALEEELKEEAELLEEEQLLIEQE-----EKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELLQE 871

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   929 GGDKAQNALKRPPGKVTSHQEKEAwepshKEATMELLRVKDRAIELERSNAALQAERQLLKEQLQHLETQNVSFSSQILT 1008
Cdd:pfam02463  872 LLLKEEELEEQKLKDELESKEEKE-----KEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEELLLEEAD 946

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 755543021  1009 LQKqsaFLQEHTTTLQTQTAKLQVENSTLSSQNAALSAQYTVLQSQQAAKEAEHE 1063
Cdd:pfam02463  947 EKE---KEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKE 998
PTZ00121 PTZ00121
MAEBL; Provisional
 122-925 1.66e-14

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 79.80  E-value: 1.66e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  122 DERDECTELIVDLTQERDYLQTQQPpSPGKFSSPDSTPSPTSSLSSEDKQHLAVELADTKARLRRVRQELEEKTEQLAdT 201
Cdd:PTZ00121 1069 DEGLKPSYKDFDFDAKEDNRADEAT-EEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARKAEDARKAEEA-R 1146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  202 RHEVDQLVLELQKAKqdniqlaaDARSARAYRDELDSLR-EKANRVERlemdlVRCKEKLHDVDFYKARMEELREDNIIL 280
Cdd:PTZ00121 1147 KAEDAKRVEIARKAE--------DARKAEEARKAEDAKKaEAARKAEE-----VRKAEELRKAEDARKAEAARKAEEERK 1213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  281 IETKAMLEEQLTASRARsdKVHELEKEnlQLKSKLHDLELDRDADKKQIEKLLEEYMVLEMAQKQSMKESAHLGWELEQL 360
Cdd:PTZ00121 1214 AEEARKAEDAKKAEAVK--KAEEAKKD--AEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEK 1289

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  361 SKNADLSDASRKSFVFELNECA--SSRILKLEKENQSLQSTIQGLRDTSlalEESSLKYGELEKENQQLSKKIEKLQTQL 438
Cdd:PTZ00121 1290 KKADEAKKAEEKKKADEAKKKAeeAKKADEAKKKAEEAKKKADAAKKKA---EEAKKAAEAAKAEAEAAADEAEAAEEKA 1366

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  439 EREKQSNQDLETLSEELIREKEQLQSGMEALKA-----DRARQIKDLEQEKGHLHQAVWSLRERPQVNSTKDVEKENRAL 513
Cdd:PTZ00121 1367 EAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKaeedkKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKA 1446

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  514 HQAVTEAGSKLSQLELEKQ-QLHRDLEEAKEKGEQAEALEKelhrLEKENEQLTKEVTSLKAATEKVEALEhqsqglELE 592
Cdd:PTZ00121 1447 DEAKKKAEEAKKAEEAKKKaEEAKKADEAKKKAEEAKKADE----AKKKAEEAKKKADEAKKAAEAKKKAD------EAK 1516

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  593 NRSLRKSLDTLQNVSVQLEGLERDKQQLGQENLELRKMVEAMRFTSAKmaQIETENRQLEREKEELRRDVELLKTLSKKS 672
Cdd:PTZ00121 1517 KAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKK--KAEEAKKAEEDKNMALRKAEEAKKAEEARI 1594

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  673 ERLELSYQSVSAENLQLQHSLESSTHKSQALQRE---------LSQLEAER----QALRRDLETLQLTHKQLEGAEEDRK 739
Cdd:PTZ00121 1595 EEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAeeekkkveqLKKKEAEEkkkaEELKKAEEENKIKAAEEAKKAEEDK 1674

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  740 ALEQEVAQLEKDKKLLEKEARRLWQQVELKDAILDDSAAKLSAAEKESRALDKELARCRDVGSKLKELEKDNRDLTKQVT 819
Cdd:PTZ00121 1675 KKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEE 1754

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  820 mhtrtlttlredlvlEKLKSQQLSSELDKLSQEL--EKVGLSKDLLLQEDDGHGDGKGKTESALKTTLAM----KEEKIV 893
Cdd:PTZ00121 1755 ---------------EKKKIAHLKKEEEKKAEEIrkEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFANiiegGKEGNL 1819

                         810       820       830
                  ....*....|....*....|....*....|..
gi 755543021  894 FLEAQVEEKESLSRQLQIELQMIKKEHEQLRQ 925
Cdd:PTZ00121 1820 VINDSKEMEDSAIKEVADSKNMQLEEADAFEK 1851
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 186-1059 1.66e-14

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 79.45  E-value: 1.66e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   186 RVRQELEEKTEQLADTRHEVDQLVLELQKAKQDNIQLAADARsarAYRDELDSLREKANRVERLEMDLVRCKEKLHDV-D 264
Cdd:pfam01576    2 RQEEEMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKN---ALQEQLQAETELCAEAEEMRARLAARKQELEEIlH 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   265 FYKARMEELREDNIIL-IETKAM------LEEQLTASRARSDKVHeLEKENLQLKSKLHD---LELDRDADKKQIEKLLE 334
Cdd:pfam01576   79 ELESRLEEEEERSQQLqNEKKKMqqhiqdLEEQLDEEEAARQKLQ-LEKVTTEAKIKKLEediLLLEDQNSKLSKERKLL 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   335 EYMVLEMaqkqsmkeSAHLGWElEQLSKNADLSDASRKSFVFELNEcassRILKLEKENQSLQSTIQGLRDTSLALEESS 414
Cdd:pfam01576  158 EERISEF--------TSNLAEE-EEKAKSLSKLKNKHEAMISDLEE----RLKKEEKGRQELEKAKRKLEGESTDLQEQI 224

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   415 LKY-GELEKENQQLSKKIEKLQTQLER-EKQSNQDLETLSE--ELIREKEQLQSGMEALKADRAR---QIKDLEQE---- 483
Cdd:pfam01576  225 AELqAQIAELRAQLAKKEEELQAALARlEEETAQKNNALKKirELEAQISELQEDLESERAARNKaekQRRDLGEEleal 304

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   484 KGHL---------HQAVWSLRERPQVNSTKDVEKENRALHQAVTEAGSKLSQLelekqqlhrdLEEAKEKGEQAE----A 550
Cdd:pfam01576  305 KTELedtldttaaQQELRSKREQEVTELKKALEEETRSHEAQLQEMRQKHTQA----------LEELTEQLEQAKrnkaN 374

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   551 LEKELHRLEKENEQLTKEVTSLKAATEKVEaleHQSQGLELEnrslrksldtLQNVSVQLEGLERDKQQLGQENLELRKM 630
Cdd:pfam01576  375 LEKAKQALESENAELQAELRTLQQAKQDSE---HKRKKLEGQ----------LQELQARLSESERQRAELAEKLSKLQSE 441

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   631 VEAMrftSAKMAQIETENRQLEREKEELRRDVELLKTLSKKSERLELSYQS----VSAENLQLQHSLESSTHKSQALQRE 706
Cdd:pfam01576  442 LESV---SSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQEETRQKLNLSTrlrqLEDERNSLQEQLEEEEEAKRNVERQ 518

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   707 LSQLEAERQALRRDLETLQLThkqLEGAEEDRKALEQEVAQL-------EKDKKLLEKEARRLWQQVELKDAILDDSAAK 779
Cdd:pfam01576  519 LSTLQAQLSDMKKKLEEDAGT---LEALEEGKKRLQRELEALtqqleekAAAYDKLEKTKNRLQQELDDLLVDLDHQRQL 595

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   780 LSAAEKESRALDKELARCRDVGSKLKE---------LEKDNRDLT------------KQVTMHTRTLTTLREDLVLEKLK 838
Cdd:pfam01576  596 VSNLEKKQKKFDQMLAEEKAISARYAEerdraeaeaREKETRALSlaraleealeakEELERTNKQLRAEMEDLVSSKDD 675

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   839 SQQLSSELDK----LSQELEKVGLSKDLLLQEDDGHGDGKGKTESALKTTLAMKEEKIVFLEAQVEEKESL----SRQLQ 910
Cdd:pfam01576  676 VGKNVHELERskraLEQQVEEMKTQLEELEDELQATEDAKLRLEVNMQALKAQFERDLQARDEQGEEKRRQlvkqVRELE 755

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   911 IELQMIKKE------------------HEQLRQTQEGGDKAQNALKRPPGKVTSHQEK-------------EAWEPSHKE 959
Cdd:pfam01576  756 AELEDERKQraqavaakkkleldlkelEAQIDAANKGREEAVKQLKKLQAQMKDLQREleearasrdeilaQSKESEKKL 835

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   960 ATME--LLRVKDRAIELERSNAALQAERQLLKEQLQHLETQNVSFSSQILTLQKQSAFLQEHTTTLQTQTAKLQVENSTL 1037
Cdd:pfam01576  836 KNLEaeLLQLQEDLAASERARRQAQQERDELADEIASGASGKSALQDEKRRLEARIAQLEEELEEEQSNTELLNDRLRKS 915

                          970       980
                   ....*....|....*....|....*.
gi 755543021  1038 SSQ----NAALSAQYTVLQSQQAAKE 1059
Cdd:pfam01576  916 TLQveqlTTELAAERSTSQKSESARQ 941
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
418-996 1.89e-14

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 79.34  E-value: 1.89e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  418 GELEK--ENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEAlKADRARQIKDLEQEKGHLHQAVWSLR 495
Cdd:PRK03918  135 GEIDAilESDESREKVVRQILGLDDYENAYKNLGEVIKEIKRRIERLEKFIKR-TENIEELIKEKEKELEEVLREINEIS 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  496 -ERPQVNSTKD-VEKENRALHqavtEAGSKLSQLELEKQQLHRDLEeakekgeqaeALEKELHRLEKENEQLTKEVTSLK 573
Cdd:PRK03918  214 sELPELREELEkLEKEVKELE----ELKEEIEELEKELESLEGSKR----------KLEEKIRELEERIEELKKEIEELE 279

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  574 AATEKVEALEHQSQGLELENRSLRKSLDTLQNVSVQLEGLERDKQQLGQENLELRKMVEamrftsaKMAQIETENRQLER 653
Cdd:PRK03918  280 EKVKELKELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEE-------RLEELKKKLKELEK 352

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  654 EKEELRRDVELLKTLSKKSERLELSYQSVSAENLQ-LQHSLESSTHKSQALQRELSQLEAERQALRRDLETLQLTHKQLE 732
Cdd:PRK03918  353 RLEELEERHELYEEAKAKKEELERLKKRLTGLTPEkLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELK 432

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  733 GA------------EEDRKAL----EQEVAQLEKDKKLLEKEARRLWQQ-VELKDAILDDSA-AKLSAAEKESRALDKEL 794
Cdd:PRK03918  433 KAkgkcpvcgreltEEHRKELleeyTAELKRIEKELKEIEEKERKLRKElRELEKVLKKESElIKLKELAEQLKELEEKL 512

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  795 ArcrdvGSKLKELEKDNRDLTKqvtmhtrtlttLREDLVLEKLKSQQLSSELDKLsQELEKvglSKDLLLQEDDGHGDGK 874
Cdd:PRK03918  513 K-----KYNLEELEKKAEEYEK-----------LKEKLIKLKGEIKSLKKELEKL-EELKK---KLAELEKKLDELEEEL 572

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  875 GKTESALK----TTLAMKEEKIVFLEAQVEEKESLS---RQLQIELQMIKKEHEQLRQTQEGGDKAQNALKRPPGKVT-- 945
Cdd:PRK03918  573 AELLKELEelgfESVEELEERLKELEPFYNEYLELKdaeKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEel 652

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 755543021  946 ----SHQEKEAWEPSHKEATMELLRVKDRAIELERSNAALQAERQLLKEQLQHLE 996
Cdd:PRK03918  653 ekkySEEEYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEERE 707
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
391-831 2.36e-14

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 79.19  E-value: 2.36e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  391 KENQSLQSTIQGLRDTsLALEESSLKYGELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSG-MEAL 469
Cdd:COG4913   265 AAARERLAELEYLRAA-LRLWFAQRRLELLEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNGGDrLEQL 343

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  470 KADRAR---QIKDLEQEKGHLHQAVWSLRErPQVNSTKDVEKENRALHQAVTEAGSKLSQLELEKQQLHRDLEEAKEkge 546
Cdd:COG4913   344 EREIERlerELEERERRRARLEALLAALGL-PLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRR--- 419

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  547 QAEALEKELHRLEKENEQLTKEVTSLKAA--------------------------------------------------- 575
Cdd:COG4913   420 ELRELEAEIASLERRKSNIPARLLALRDAlaealgldeaelpfvgelievrpeeerwrgaiervlggfaltllvppehya 499

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  576 ----------------TEKVEALEHQSQGLELENRSL-RK--------------------------SLDTLQNV--SVQL 610
Cdd:COG4913   500 aalrwvnrlhlrgrlvYERVRTGLPDPERPRLDPDSLaGKldfkphpfrawleaelgrrfdyvcvdSPEELRRHprAITR 579

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  611 EGLERDKQQLGQENLelRKMVEAMRF----TSAKMAQIETENRQLEREKEELRRDVELLKTLSKKSERLELSYQSVSAEN 686
Cdd:COG4913   580 AGQVKGNGTRHEKDD--RRRIRSRYVlgfdNRAKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYS 657

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  687 LQLQhslessthKSQALQRELSQLEAERQALRR---DLETLQlthKQLEGAEEDRKALEQEVAQLEKDKKLLEKEARRLW 763
Cdd:COG4913   658 WDEI--------DVASAEREIAELEAELERLDAssdDLAALE---EQLEELEAELEELEEELDELKGEIGRLEKELEQAE 726

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  764 QQVELKDAILDDsAAKLSAAEKESRALDK--ELARCRDVGSKLKELEKDNRDLTKQVTMHTRTLTTLRED 831
Cdd:COG4913   727 EELDELQDRLEA-AEDLARLELRALLEERfaAALGDAVERELRENLEERIDALRARLNRAEEELERAMRA 795
HkD_SF cd22211
Hook domain-containing proteins superfamily; The Hook domain superfamily includes Hook adaptor ...
 35-85 3.00e-14

Hook domain-containing proteins superfamily; The Hook domain superfamily includes Hook adaptor proteins, Hook-related proteins and nuclear mitotic apparatus protein (NuMA). They share an N-terminal conserved globular Hook domain, which folds as a variant of the helical calponin homology (CH) domain with an extended alpha-helix. The Hook domain is responsible for the binding of microtubule. The Hook family includes microtubule-binding proteins, Hook1-3. Hook1 is required for spermatid differentiation. Hook2 contributes to the establishment and maintenance of centrosome function. Hook3 is an adaptor protein for microtubule-dependent intracellular vesicle and protein trafficking, and is involved in Golgi and endosome transport. Hook proteins are components of the FTS/Hook/FHIP complex (FHF complex), which may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting (HOPS) complex. The Hook-related protein (HkRP) family includes Daple, Girdin and Gipie. Daple, also called Dvl-associating protein with a high frequency of leucine residues, or coiled-coil domain-containing protein 88C(CCDC88C), or Hook-related protein 2 (HkRP2), is a novel non-receptor nucleotide exchange factor (GEF) required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling. Girdin, also called Akt phosphorylation enhancer (APE), or coiled-coil domain-containing protein 88A (CCDC88A), or G alpha-interacting vesicle-associated protein (GIV), or Girders of actin filament, or Hook-related protein 1 (HkRP1), is a bifunctional modulator of guanine nucleotide-binding proteins (G proteins). Gipie, also called GRP78-interacting protein induced by ER stress, or coiled-coil domain-containing protein 88B(CCDC88B), or brain leucine zipper domain-containing protein, or Hook-related protein 3 (HkRP3), is a novel actin cytoskeleton-binding protein and Akt substrate that regulates cell migratory responses in various biological contexts. NuMA, also called nuclear mitotic apparatus protein 1, or nuclear matrix protein-22 (NMP-22), or SP-H antigen, is a microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignment and the segregation of chromosomes during mitotic cell division.


Pssm-ID: 411792  Cd Length: 145  Bit Score: 71.92  E-value: 3.00e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 755543021   35 GKSMEEIKKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEVTH 85
Cdd:cd22211    95 DGDEEEIVKLLELVLGAAVQCENKEEYIARIQQLDESTQAELMLIIQEVLE 145
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 183-923 3.00e-14

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 78.94  E-value: 3.00e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   183 RLRRVRQELEEKTEQladtrHEVDQLVLELQKAKQDNI---------QLAADARSARAYRDELDSLREKANRVERLEMDL 253
Cdd:TIGR00606  190 TLRQVRQTQGQKVQE-----HQMELKYLKQYKEKACEIrdqitskeaQLESSREIVKSYENELDPLKNRLKEIEHNLSKI 264

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   254 VRCKEKLHDVDFYKARMEELRED-NIILIETKAMLEEQLTA-SRARSDKVHELEKENLQLKSKLHDLELDRDADKKQIEK 331
Cdd:TIGR00606  265 MKLDNEIKALKSRKKQMEKDNSElELKMEKVFQGTDEQLNDlYHNHQRTVREKERELVDCQRELEKLNKERRLLNQEKTE 344

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   332 LLEEYMVLEMAQKQSMKESAHLGWELEQLSKNADLSDASRKSFV-FELNECASSRILKLEKE----NQSLQSTIQGLRDT 406
Cdd:TIGR00606  345 LLVEQGRLQLQADRHQEHIRARDSLIQSLATRLELDGFERGPFSeRQIKNFHTLVIERQEDEaktaAQLCADLQSKERLK 424

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   407 SLALEESSLKYGELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEAL-KADRARQIKDLEQEKG 485
Cdd:TIGR00606  425 QEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSSDRILELDQELRKAERELsKAEKNSLTETLKKEVK 504

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   486 HLHQA----VWSLRERPQVNSTKDVEKENRALHQAVT-EAGSKLSQLELEKQQLHRDLEEAKEKGEQAEALEKELHRLEK 560
Cdd:TIGR00606  505 SLQNEkadlDRKLRKLDQEMEQLNHHTTTRTQMEMLTkDKMDKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSK 584

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   561 ENEQLTKEVTSLKAATEKVEALEHQ--SQGLELENRSLRKSLDTLQNVSVQLE--GLERDKQQLGQENLELRKMVEAMRF 636
Cdd:TIGR00606  585 EINQTRDRLAKLNKELASLEQNKNHinNELESKEEQLSSYEDKLFDVCGSQDEesDLERLKEEIEKSSKQRAMLAGATAV 664

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   637 TSAKMAQIETENR----------QLEREKEELRRDVE-LLKTLSKKSERLELSYQSVSAENLQLQHSLESSTHKSQALQR 705
Cdd:TIGR00606  665 YSQFITQLTDENQsccpvcqrvfQTEAELQEFISDLQsKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEK 744

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   706 ELSQLEAERQALRRDLE----TLQLTHKQLE---GAEEDRKALEQEVAQLEKDKKLLEKEARRLWQQVELKDAIldDSAA 778
Cdd:TIGR00606  745 EIPELRNKLQKVNRDIQrlknDIEEQETLLGtimPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGS--DLDR 822

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   779 KLSAAEKESRALDKELARCRDVGSKLKELEKDNRDLTKQVTMHTRTLTTLREDLVLEKLKSQQLSSELDKLSQELEKvgl 858
Cdd:TIGR00606  823 TVQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQS--- 899

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755543021   859 skdlLLQEDDGHGDGKGKTESALKTTLAMKEEKIvfleaqvEEKESLSRQLQIELQMIKKEHEQL 923
Cdd:TIGR00606  900 ----LIREIKDAKEQDSPLETFLEKDQQEKEELI-------SSKETSNKKAQDKVNDIKEKVKNI 953
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 421-1055 6.62e-14

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 77.85  E-value: 6.62e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   421 EKENQQLSKKIEKLQTQLE--------------REKQSNQDLETLSEELIREKEQLQSGMEALKADRARQIKDLEQ---- 482
Cdd:pfam15921  102 EKQKFYLRQSVIDLQTKLQemqmerdamadirrRESQSQEDLRNQLQNTVHELEAAKCLKEDMLEDSNTQIEQLRKmmls 181

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   483 EKGHLHQAVWSLRERPQVNSTKDVEKEN------RALHQAVT----EAGSKLSQLELEKQQLHRDLEEAKEKGEQAEALE 552
Cdd:pfam15921  182 HEGVLQEIRSILVDFEEASGKKIYEHDSmstmhfRSLGSAISkilrELDTEISYLKGRIFPVEDQLEALKSESQNKIELL 261

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   553 KELH--RLEKENEQLTKEVTSL--KAATEKVEALEHQSQgLEL-------ENRSLRKSLDTLQNVSVQLEGLERDKQQLG 621
Cdd:pfam15921  262 LQQHqdRIEQLISEHEVEITGLteKASSARSQANSIQSQ-LEIiqeqarnQNSMYMRQLSDLESTVSQLRSELREAKRMY 340

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   622 QENLElrKMVEAMRFTSAKMAQIETENRQLEREKEELRRDVE-LLKTLSKKSERLELSYQsvsaENLQLQHSLESSTHKS 700
Cdd:pfam15921  341 EDKIE--ELEKQLVLANSELTEARTERDQFSQESGNLDDQLQkLLADLHKREKELSLEKE----QNKRLWDRDTGNSITI 414

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   701 QALQRELSQLEAERQALRRDLETL------QLTHKQ--LEGAEEDRKALEQEVAQLEKDKKLLEKEARRLWQQ---VELK 769
Cdd:pfam15921  415 DHLRRELDDRNMEVQRLEALLKAMksecqgQMERQMaaIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKkmtLESS 494

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   770 DAILDDSAAKLSAAEKESRALDKELARCRD-VGSKLKELE--KDNRDLTKQVTMHTRT--LTTLREDLVLEKLKSQqlss 844
Cdd:pfam15921  495 ERTVSDLTASLQEKERAIEATNAEITKLRSrVDLKLQELQhlKNEGDHLRNVQTECEAlkLQMAEKDKVIEILRQQ---- 570

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   845 eLDKLSQELEKVGLSKDLLLQEDDGHGDGKGKTESALKTTLAMKEEKivflEAQVEEKESLSRQLQIE-LQMIKKEHEQL 923
Cdd:pfam15921  571 -IENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRLELQEFKILKDKK----DAKIRELEARVSDLELEkVKLVNAGSERL 645

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   924 RQT---QEGGDKAQNALKRPPGKVTS-HQEKEAWEPSHKEATMELLRVKDR-AIELERSNAALQAERQLLKEQ------- 991
Cdd:pfam15921  646 RAVkdiKQERDQLLNEVKTSRNELNSlSEDYEVLKRNFRNKSEEMETTTNKlKMQLKSAQSELEQTRNTLKSMegsdgha 725

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755543021   992 ---LQHLETQNVSFSSQILTLQKQSAFLQEHTTT-------LQTQTAKLQVENSTLSSQNAALSAQYTVLQSQQ 1055
Cdd:pfam15921  726 mkvAMGMQKQITAKRGQIDALQSKIQFLEEAMTNankekhfLKEEKNKLSQELSTVATEKNKMAGELEVLRSQE 799
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 649-1300 7.37e-14

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 77.28  E-value: 7.37e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  649 RQLEREKEELRRDVELL---KTLSKKSERLE-----LSYQSVSAENLQLQHSLESSTHKSQALQRELSQLEAERQALRRD 720
Cdd:COG1196   196 GELERQLEPLERQAEKAeryRELKEELKELEaelllLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  721 LETLQLthkQLEGAEEDRKALEQEVAQLEKDKKLLEKEARRLWQQVELKDAILDDSAAKLSAAEKESRALDKELArcrDV 800
Cdd:COG1196   276 LEELEL---ELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELE---EA 349

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  801 GSKLKELEKDNRDLTKQVTMHTRTLTTLREDLvleklkSQQLSSELDKLSQELEKVGLSKDLLLQEDDghgdgkgktesa 880
Cdd:COG1196   350 EEELEEAEAELAEAEEALLEAEAELAEAEEEL------EELAEELLEALRAAAELAAQLEELEEAEEA------------ 411

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  881 lkttlamKEEKIVFLEAQVEEKESLSRQLQIELQMIKKEHEQLRQTQEGGDKAQNALKRPpgkvtsHQEKEAWEPSHKEA 960
Cdd:COG1196   412 -------LLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLEL------LAELLEEAALLEAA 478

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  961 TMELLRVKDRAIELERSNAALQAERQLLKEQLQHLEtQNVSFSSQILTLQKQSAFLQEHTTTLQTQTAKLQVENSTLSSQ 1040
Cdd:COG1196   479 LAELLEELAEAAARLLLLLEAEADYEGFLEGVKAAL-LLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDE 557

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1041 NAALSAQYtvLQSQQAAKEAEHEGLQQQQEQLAAVYEALLQDHKHLGTLyecqsseyEALIRQHSCLKTLHRNLELEHKE 1120
Cdd:COG1196   558 VAAAAIEY--LKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLV--------ASDLREADARYYVLGDTLLGRTL 627

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1121 LGERHGDLQQRKAELEELEKVLSTEREALE-REQKTNAIATSENQRLRGELDRISFLHQQLKGEYEELHAHTKElktsln 1199
Cdd:COG1196   628 VAARLEAALRRAVTLAGRLREVTLEGEGGSaGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLA------ 701

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1200 nsQLELSRWQVRFDELKEQhqsmdisltkmdnhcellsrlkgnLEEENHHLLSQIQLLSQQNQMLLEQNMESKEQYHEEQ 1279
Cdd:COG1196   702 --EEEEERELAEAEEERLE------------------------EELEEEALEEQLEAEREELLEELLEEEELLEEEALEE 755

                         650       660
                  ....*....|....*....|.
gi 755543021 1280 KQYIDKLNALRRHKEKLEEKI 1300
Cdd:COG1196   756 LPEPPDLEELERELERLEREI 776
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 190-676 1.09e-13

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 76.60  E-value: 1.09e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   190 ELEEKTEQLADTRHEVDQL---VLELQKAKQDNIQLAADARSARAYRDEL-DSLREKANRVERLEMDLVRCKEKLHDVdf 265
Cdd:TIGR04523  181 EKLNIQKNIDKIKNKLLKLellLSNLKKKIQKNKSLESQISELKKQNNQLkDNIEKKQQEINEKTTEISNTQTQLNQL-- 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   266 ykarMEELREDNIILIETKAMLEEQltasrarSDKVHELEKENLQLKSKLHDLELDRDAD-----KKQIEKLLEEYMVLE 340
Cdd:TIGR04523  259 ----KDEQNKIKKQLSEKQKELEQN-------NKKIKELEKQLNQLKSEISDLNNQKEQDwnkelKSELKNQEKKLEEIQ 327

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   341 MAQKQSMKESAHLGWELEQLSKNADLSDASRKSFVFELNEcASSRILKLEKENQSLQstiqglrdtslaleesslkygel 420
Cdd:TIGR04523  328 NQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEE-KQNEIEKLKKENQSYK----------------------- 383

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   421 eKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEALKADRARQ---IKDLEQEKGHLHQAVWSLrer 497
Cdd:TIGR04523  384 -QEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNnseIKDLTNQDSVKELIIKNL--- 459

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   498 pqvNSTKDVEKEnralhqavteagsKLSQLELEKQQLHRDLE----EAKEKGEQAEALEKELHRLEKENEQLTKEVTSLK 573
Cdd:TIGR04523  460 ---DNTRESLET-------------QLKVLSRSINKIKQNLEqkqkELKSKEKELKKLNEEKKELEEKVKDLTKKISSLK 523

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   574 AATEKVEALEHQ-------------SQGLELENRSLRKSLDTLQNVSVQL-----------EGLERDKQQLGQENLELRK 629
Cdd:TIGR04523  524 EKIEKLESEKKEkeskisdledelnKDDFELKKENLEKEIDEKNKEIEELkqtqkslkkkqEEKQELIDQKEKEKKDLIK 603

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*..
gi 755543021   630 MVEamrftsAKMAQIETENRQLEREKEELRRDVELLKTLSKKSERLE 676
Cdd:TIGR04523  604 EIE------EKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLK 644
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 469-1196 1.13e-13

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 76.93  E-value: 1.13e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   469 LKADRARQIKDLEQEKGHLHQAVWSLRERPQVnsTKDVEKENRALHQAVTEAGSKLSQLEL---EKQQLHRDLEEAKEKG 545
Cdd:TIGR00618  192 LHGKAELLTLRSQLLTLCTPCMPDTYHERKQV--LEKELKHLREALQQTQQSHAYLTQKREaqeEQLKKQQLLKQLRARI 269

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   546 EQAEALEKELHRLEKENEQLTKeVTSLKAATEKVEALEHQSQG----LELENRSLRKSLDTLQNVSVQ---LEGLERDKQ 618
Cdd:TIGR00618  270 EELRAQEAVLEETQERINRARK-AAPLAAHIKAVTQIEQQAQRihteLQSKMRSRAKLLMKRAAHVKQqssIEEQRRLLQ 348

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   619 QLGQENLELRKMVEAMRFTSAKMAQIETENRQLEREKEELRRDVELLKTLSKKSERLElsyqsvsaenlQLQHSLESSTH 698
Cdd:TIGR00618  349 TLHSQEIHIRDAHEVATSIREISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQ-----------REQATIDTRTS 417

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   699 KSQALQRELSQLEAERQALRRDLETLQLTHKQLEGAEEDRKALEQEVAQLEKDKKLLEKEARRLWQQVELKDAILDDSAA 778
Cdd:TIGR00618  418 AFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQLQTKEQIHLQETRKKAVVLARLL 497

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   779 KLSAAEKESRALDKELARCRDVG-------SKLKELEKDNRDLTKQVTMHTRTLTTLREDLVLEKLKSQQLSSELDKLSQ 851
Cdd:TIGR00618  498 ELQEEPCPLCGSCIHPNPARQDIdnpgpltRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQ 577

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   852 ELEKVGLSKDLLLQEddghgdgkgkTESALKTTLAMKEEKIVFLEAQVEEKESLsrQLQIELQMIKKEHEQLRQTQEggd 931
Cdd:TIGR00618  578 CDNRSKEDIPNLQNI----------TVRLQDLTEKLSEAEDMLACEQHALLRKL--QPEQDLQDVRLHLQQCSQELA--- 642

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   932 KAQNALKRPPGKVTSHQEKEAWEPSHKEATMELLRVkdraielERSNAALQAERQLLKEQLQHLETQNVSFSSQILTLQK 1011
Cdd:TIGR00618  643 LKLTALHALQLTLTQERVREHALSIRVLPKELLASR-------QLALQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEE 715

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1012 QSAFLQEHTTTLQTQTAKLQVENSTLSsqnaalsaqytvlQSQQAAKEAEHEGLqqqqeqlaavyeallqdhKHLGTLYE 1091
Cdd:TIGR00618  716 YDREFNEIENASSSLGSDLAAREDALN-------------QSLKELMHQARTVL------------------KARTEAHF 764

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1092 CQSSEYEALIRQHSCLKTLHRNLELEHKELGERHGDLQQRKAELE------ELEKVLSTEREALEREQKTNAIAtsENQR 1165
Cdd:TIGR00618  765 NNNEEVTAALQTGAELSHLAAEIQFFNRLREEDTHLLKTLEAEIGqeipsdEDILNLQCETLVQEEEQFLSRLE--EKSA 842

                          730       740       750
                   ....*....|....*....|....*....|.
gi 755543021  1166 LRGELDRISFLHQQLKGEYEELHAHTKELKT 1196
Cdd:TIGR00618  843 TLGEITHQLLKYEECSKQLAQLTQEQAKIIQ 873
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 551-1302 6.22e-13

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 74.29  E-value: 6.22e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   551 LEKELHRLEKENEQLTKEVTSL-KAATEKVE---ALEHQSQGLELENRSLRKSLDTlqnvsvqleglerDKQQLGQENLE 626
Cdd:TIGR04523   38 LEKKLKTIKNELKNKEKELKNLdKNLNKDEEkinNSNNKIKILEQQIKDLNDKLKK-------------NKDKINKLNSD 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   627 LRKMVEAMRFTSAKMAQIETENRQLEREKEELRRDVELLKTLSKKSERlELSYQSVSAENLQLQ-HSLESSTHKsqaLQR 705
Cdd:TIGR04523  105 LSKINSEIKNDKEQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEK-ELEKLNNKYNDLKKQkEELENELNL---LEK 180

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   706 ELSQLEAERQALRRDLETLQLTHKQLEGAEEDRKALEQEVAQLEKDKKLLEKEARRLWQQVELKDAILDDSAAKLSAAEK 785
Cdd:TIGR04523  181 EKLNIQKNIDKIKNKLLKLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKD 260

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   786 ESRALDKELARcrdvgsKLKELEKDNR---DLTKQVtmhtrtlttlredlvleklksQQLSSELDKLSQELEKvGLSKDL 862
Cdd:TIGR04523  261 EQNKIKKQLSE------KQKELEQNNKkikELEKQL---------------------NQLKSEISDLNNQKEQ-DWNKEL 312

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   863 llqeddghgdgkgktesalKTTLAMKEEKIVFLEAQVEEKESLSRQLQIELQMIKKEHEQLRqtqeggdkaqnalkrppg 942
Cdd:TIGR04523  313 -------------------KSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSE------------------ 355

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   943 kvTSHQEKEawepshkeatmELLRVKDRAIELersnaaLQAERQLLKEQLQHLETQNVSFSSQILTLQKQSAFLQEHTTT 1022
Cdd:TIGR04523  356 --SENSEKQ-----------RELEEKQNEIEK------LKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKK 416

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1023 LQTQTAKLQVENSTLSSQNAALSAQYTVLQSQQAAKEAEHEGLQQQQEQLAAVYEALLQDHKHLGTLYECQSSEYEALIR 1102
Cdd:TIGR04523  417 LQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEK 496

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1103 QHSCLKTlhrnlelEHKELGERHGDLQQRKAELEELEKVLSTEReaLEREQKTNAIAT---SENQRLRGELDRISFLHQQ 1179
Cdd:TIGR04523  497 ELKKLNE-------EKKELEEKVKDLTKKISSLKEKIEKLESEK--KEKESKISDLEDelnKDDFELKKENLEKEIDEKN 567

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1180 lkGEYEELHAHTKELKTSLNNSQLELSRWQVRFDELKEQHQSMDISLTKMDNHCELlsrlkgnLEEENHHLLSQIQLLsq 1259
Cdd:TIGR04523  568 --KEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEK-------AKKENEKLSSIIKNI-- 636

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|...
gi 755543021  1260 qnQMLLEQNMESKEQYHEEQKQYIDKLNALRRHKEKLEEKIMD 1302
Cdd:TIGR04523  637 --KSKKNKLKQEVKQIKETIKEIRNKWPEIIKKIKESKTKIDD 677
PTZ00121 PTZ00121
MAEBL; Provisional
 267-987 7.70e-13

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 74.41  E-value: 7.70e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  267 KARMEELREDNIILIETKAMLEEqltaSRARSDKVHELEK-ENLQLKSKLHDLELDRDADKKQIEKLLEEYMVLEMAQKQ 345
Cdd:PTZ00121 1097 FGKAEEAKKTETGKAEEARKAEE----AKKKAEDARKAEEaRKAEDARKAEEARKAEDAKRVEIARKAEDARKAEEARKA 1172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  346 SMKESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDTSLALEESSLKYGELEKENQ 425
Cdd:PTZ00121 1173 EDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNE 1252

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  426 QLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEALKADRARQIKDLEQEkghlhqavwSLRERPQVNSTKD 505
Cdd:PTZ00121 1253 EIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKK---------AEEAKKADEAKKK 1323

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  506 VEKENRALHQAVTEAGSKLSQLELEKQQLHRDLEEAKEKGEQAEALEKELHRLEKENEQLTKEVTSLKAATE-KVEALEH 584
Cdd:PTZ00121 1324 AEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEaKKKAEED 1403

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  585 QSQGLELENRSL-RKSLDTLQNVSVQLEGLE---------RDKQQLGQENLELRKMVEAMRFTSAKMAQIETENRQLERE 654
Cdd:PTZ00121 1404 KKKADELKKAAAaKKKADEAKKKAEEKKKADeakkkaeeaKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAK 1483

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  655 K-EELRRDVELLKT----LSKKSERLELSYQSVSAENLQLQHSLESSTHKSQAlqRELSQLEAERQA--LRRDLETLQLT 727
Cdd:PTZ00121 1484 KaDEAKKKAEEAKKkadeAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKA--DEAKKAEEKKKAdeLKKAEELKKAE 1561

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  728 HKQleGAEEDRKALEQEVAQLEKDKKLLEKEARRLWQQVELKDAILDDSAAKLSAAEkESRALDKELARCRDVGSKLKEL 807
Cdd:PTZ00121 1562 EKK--KAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAE-EAKIKAEELKKAEEEKKKVEQL 1638

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  808 EKDNRDLTKQvtmhTRTLTTLREDLVLEKLKSQQLSSELDKLSQELEKvglskdlllQEDDghgdgKGKTESALKTTlAM 887
Cdd:PTZ00121 1639 KKKEAEEKKK----AEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKK---------AEED-----EKKAAEALKKE-AE 1699

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  888 KEEKIVFLEAQVEEKESLSRQLQIELQMIKKEHEQL-RQTQEGGDKAQNALKRPPGKVTSHQEKEAWEPSHKEATMELLR 966
Cdd:PTZ00121 1700 EAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAkKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEA 1779

                         730       740
                  ....*....|....*....|.
gi 755543021  967 VKDRAIELERSNAALQAERQL 987
Cdd:PTZ00121 1780 VIEEELDEEDEKRRMEVDKKI 1800
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
174-730 7.97e-13

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 74.18  E-value: 7.97e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  174 AVELADTKARLRRVRQELEEKTEQLADTRHEVDQLVLELQKAKQDNIQLAADARSARAYRDELDSlrekaNRVERLEMDL 253
Cdd:COG4913   273 ELEYLRAALRLWFAQRRLELLEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNGG-----DRLEQLEREI 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  254 VRCKEKLHDV----DFYKARMEELREDniiLIETKAMLEEQLTASRARSDKVHELEKEnlqLKSKLHDLELDRDADKKQI 329
Cdd:COG4913   348 ERLERELEERerrrARLEALLAALGLP---LPASAEEFAALRAEAAALLEALEEELEA---LEEALAEAEAALRDLRREL 421

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  330 EKLLEEYMVLEMAQKQSMKESAHLgweLEQLSKNADLsDASRKSFVFELnecassriLKLEKENQSLQSTIQG-LRDTSL 408
Cdd:COG4913   422 RELEAEIASLERRKSNIPARLLAL---RDALAEALGL-DEAELPFVGEL--------IEVRPEEERWRGAIERvLGGFAL 489

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  409 AL------EESSLKYgeLEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEEL-IRE-------KEQLQSGMEALKADRA 474
Cdd:COG4913   490 TLlvppehYAAALRW--VNRLHLRGRLVYERVRTGLPDPERPRLDPDSLAGKLdFKPhpfrawlEAELGRRFDYVCVDSP 567

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  475 RQIKDLEQ---EKGHLHQAvWSLRErpqvnstKDVEKENRALHQAVTEAGSKLSQLELEKQQLHRDLEEAKekgEQAEAL 551
Cdd:COG4913   568 EELRRHPRaitRAGQVKGN-GTRHE-------KDDRRRIRSRYVLGFDNRAKLAALEAELAELEEELAEAE---ERLEAL 636

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  552 EKELHRLEKENEQLTKeVTSLKAATEKVEALEHQSQGLELENRSLRKSLDTLQNVSVQLEGLERDKQQLGQENLELRKmv 631
Cdd:COG4913   637 EAELDALQERREALQR-LAEYSWDEIDVASAEREIAELEAELERLDASSDDLAALEEQLEELEAELEELEEELDELKG-- 713

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  632 eamrftsaKMAQIETENRQLEREKEELRRDVELLKTLSKKSERLELsyqsvsAENLQLQHSLESSTHKSQALQRELSQLE 711
Cdd:COG4913   714 --------EIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALL------EERFAAALGDAVERELRENLEERIDALR 779

                         570
                  ....*....|....*....
gi 755543021  712 AERQALRRDLETLQLTHKQ 730
Cdd:COG4913   780 ARLNRAEEELERAMRAFNR 798
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 250-1305 8.06e-13

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 74.06  E-value: 8.06e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   250 EMDLVRCKEKLHDVDfykARMEELREDNIILIETKAMLEEQLTASRARSDKVHE----LEKENLQLKSKLHDLE--LDRD 323
Cdd:pfam01576   11 EEELQKVKERQQKAE---SELKELEKKHQQLCEEKNALQEQLQAETELCAEAEEmrarLAARKQELEEILHELEsrLEEE 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   324 ADKK---QIEKLLEEYMVLEMAQKQSMKESAHLGWELEQLSknadlSDASRKSFVFELNECASSRIlKLEKENQSLQSTI 400
Cdd:pfam01576   88 EERSqqlQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVT-----TEAKIKKLEEDILLLEDQNS-KLSKERKLLEERI 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   401 QGLRDTSLALEESSLKYGELEKENQQLskkIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEALKADRARQIKDL 480
Cdd:pfam01576  162 SEFTSNLAEEEEKAKSLSKLKNKHEAM---ISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQAQIAELRAQL 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   481 EQEKGHLHQAVWSLRERPQVNSTkdVEKENRALHQAVTEAgskLSQLELEKQQLHRDLEEAKEKGEQAEALEKEL----- 555
Cdd:pfam01576  239 AKKEEELQAALARLEEETAQKNN--ALKKIRELEAQISEL---QEDLESERAARNKAEKQRRDLGEELEALKTELedtld 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   556 -----HRLEKENEQltkEVTSLKAATEKvEALEHQSQGLELEnrslRKSLDTLQNVSVQLE-------GLERDKQQLGQE 623
Cdd:pfam01576  314 ttaaqQELRSKREQ---EVTELKKALEE-ETRSHEAQLQEMR----QKHTQALEELTEQLEqakrnkaNLEKAKQALESE 385

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   624 NLELrkmVEAMRFTSAKMAQIETENRQLEREKEELR---RDVELLKT-LSKKSERLELSYQSVSaenlqlqHSLESSTHK 699
Cdd:pfam01576  386 NAEL---QAELRTLQQAKQDSEHKRKKLEGQLQELQarlSESERQRAeLAEKLSKLQSELESVS-------SLLNEAEGK 455

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   700 SQALQRELSQLEAERQALRRDL--ET---LQLTHKqLEGAEEDRKALEQEVAQLEKDKKLLEKEARRLWQQVELKDAILD 774
Cdd:pfam01576  456 NIKLSKDVSSLESQLQDTQELLqeETrqkLNLSTR-LRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLE 534

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   775 DSAAKLSAAEKESRALDKELarcRDVGSKLKELEKDNRDLTKQVTMHTRTLttlrEDLVLEKLKSQQLSSELDKLSQELe 854
Cdd:pfam01576  535 EDAGTLEALEEGKKRLQREL---EALTQQLEEKAAAYDKLEKTKNRLQQEL----DDLLVDLDHQRQLVSNLEKKQKKF- 606

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   855 kvglskDLLLQEddghgdgkgktESALKTTLAMKEEKIvflEAQVEEKE----SLSRQLQiELQMIKKEHEQLRQTQEgg 930
Cdd:pfam01576  607 ------DQMLAE-----------EKAISARYAEERDRA---EAEAREKEtralSLARALE-EALEAKEELERTNKQLR-- 663

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   931 dkaqnalkrppgkvtshqekeawepshkeATME-LLRVKD----RAIELERSNAALQAERQLLKEQLQHLETQNVSFSSQ 1005
Cdd:pfam01576  664 -----------------------------AEMEdLVSSKDdvgkNVHELERSKRALEQQVEEMKTQLEELEDELQATEDA 714

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1006 ILTLQ-KQSAFLQEHTTTLQTQTAKLQVENSTLSSQNAALSAQYTVLQSQQAAKEAEHEGLQQQQEQLAAVY-------- 1076
Cdd:pfam01576  715 KLRLEvNMQALKAQFERDLQARDEQGEEKRRQLVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQIdaankgre 794

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1077 EALLQDHKHLGTLYECQSSEYEALIRQHSCLkTLHRNLELEHKELGERHGDLQQRKAELEELEKVLSTEREALEREQKTN 1156
Cdd:pfam01576  795 EAVKQLKKLQAQMKDLQRELEEARASRDEIL-AQSKESEKKLKNLEAELLQLQEDLAASERARRQAQQERDELADEIASG 873

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1157 AiatSENQRLRGELDRISFLHQQLKGEYEELHAHTKELKTSLNNSQLelsrwqvrfdelkeQHQSMDISLTKMDNHCELL 1236
Cdd:pfam01576  874 A---SGKSALQDEKRRLEARIAQLEEELEEEQSNTELLNDRLRKSTL--------------QVEQLTTELAAERSTSQKS 936

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1237 SRLKGNLEEENHHLLSQIQLLSQQ---NQMLLEQNMESK-----EQYHEEQKQYIDKLNALRRHKEKLEEKIM------- 1301
Cdd:pfam01576  937 ESARQQLERQNKELKAKLQEMEGTvksKFKSSIAALEAKiaqleEQLEQESRERQAANKLVRRTEKKLKEVLLqvederr 1016


                   ....*.
gi 755543021  1302 --DQYK 1305
Cdd:pfam01576 1017 haDQYK 1022
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
382-851 1.35e-12

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 72.88  E-value: 1.35e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  382 ASSRILKLEKENQSLQSTIQGLRDtSLALEESSLKYGELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQ 461
Cdd:COG4717   100 LEEELEELEAELEELREELEKLEK-LLQLLPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEE 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  462 LQSGMEALKADRARQIKDLEQEKGHLHQAVWSLRERpqvnsTKDVEKENRALHQAVTEAGSKLSQLELEkQQLHRDLEEA 541
Cdd:COG4717   179 LEELLEQLSLATEEELQDLAEELEELQQRLAELEEE-----LEEAQEELEELEEELEQLENELEAAALE-ERLKEARLLL 252

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  542 KEKGEQAEALEKELHRLEKENE-----------------QLTKEVTSLKAATEKVEALEHQSQGLELENRSLRKSLDTLQ 604
Cdd:COG4717   253 LIAAALLALLGLGGSLLSLILTiagvlflvlgllallflLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPP 332

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  605 NVSV-QLEGLERDKQQLGQENLELRKMVEAMRFTSAKMAQIETENRQLEREKEELRRDVELLKTLSKKSERLELSYQSVS 683
Cdd:COG4717   333 DLSPeELLELLDRIEELQELLREAEELEEELQLEELEQEIAALLAEAGVEDEEELRAALEQAEEYQELKEELEELEEQLE 412

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  684 AENLQLQHSLEssTHKSQALQRELSQLEAERQALRRDLETLQlthkqlegaeEDRKALEQEVAQLEKDKKLLEKEARRLW 763
Cdd:COG4717   413 ELLGELEELLE--ALDEEELEEELEELEEELEELEEELEELR----------EELAELEAELEQLEEDGELAELLQELEE 480

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  764 QQVELKDAILDDSAAKLSAAekesrALDKELARCRDvgSKLKELEKDNRDLTKQVTMHTRTLTTLREDLVLEKLKSQQLS 843
Cdd:COG4717   481 LKAELRELAEEWAALKLALE-----LLEEAREEYRE--ERLPPVLERASEYFSRLTDGRYRLIRIDEDLSLKVDTEDGRT 553


                  ....*...
gi 755543021  844 SELDKLSQ 851
Cdd:COG4717   554 RPVEELSR 561
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 508-1302 2.70e-12

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 72.39  E-value: 2.70e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   508 KENRALHQAVTEAGSKLSQLELEKQQLHRDLEEAKEKGEQAEALEKELHRLEKENEQLTKEVTSLKAATEKVEalEHQSQ 587
Cdd:TIGR00606  186 KALETLRQVRQTQGQKVQEHQMELKYLKQYKEKACEIRDQITSKEAQLESSREIVKSYENELDPLKNRLKEIE--HNLSK 263

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   588 GLELENrslrksldtlqnvsvQLEGLERDKQQLGQENLEL-RKMVEAMRFTSAKMAQIETENRQLEREKEELRRDVEllK 666
Cdd:TIGR00606  264 IMKLDN---------------EIKALKSRKKQMEKDNSELeLKMEKVFQGTDEQLNDLYHNHQRTVREKERELVDCQ--R 326

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   667 TLSK-KSERLELSYQSVSAENLQLQHSLESSTHKSQALQRELSQLEAERQALRRDLETLQLTHKQL--------EGAEED 737
Cdd:TIGR00606  327 ELEKlNKERRLLNQEKTELLVEQGRLQLQADRHQEHIRARDSLIQSLATRLELDGFERGPFSERQIknfhtlviERQEDE 406

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   738 RKALEQEVAQLEKDKKLLEKEARRLWQQVELKDAILDDSAAKLSAAEKESRALDKEL----ARCRDVGSKLKELEKDNRD 813
Cdd:TIGR00606  407 AKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELqqleGSSDRILELDQELRKAERE 486

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   814 LTKqVTMHTRTLTTLREDLVLEKLKSqQLSSELDKLSQELEKVGLSKDLLLQEDDGHGDGKGKTESALKTTLAMKEEKIV 893
Cdd:TIGR00606  487 LSK-AEKNSLTETLKKEVKSLQNEKA-DLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQIRKIKSRHSDELTS 564

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   894 FL-----EAQVEEK-ESLSRQLQIELQMIKKEHEQLRQTQEGGDKAQNALKRPPGKVTSHQEKEAWEPSHKEATMELLRV 967
Cdd:TIGR00606  565 LLgyfpnKKQLEDWlHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLFDVCGSQDEESDLERL 644

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   968 KDRAIELERSNAALQAERQLLKEQLQHLETQNVSFSSQILTLQKQSAFLQEHTTTLQTQTAKLQVENSTLSSQNAALSAQ 1047
Cdd:TIGR00606  645 KEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKR 724

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1048 YTVLQSQQAAKEAEHEGLQQQQEQLAAVYEALLQDHKHLGTLYECQSSEYEALIRQHSCLKTLHRN---LELEHKELGER 1124
Cdd:TIGR00606  725 RDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDvtiMERFQMELKDV 804

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1125 HGDLQQRKAELEELEKVLSTEREALEREQKTNaiatsenqrlrgELDRISFLHQQLKGEYEELHAHTKELKTSLNnsqlE 1204
Cdd:TIGR00606  805 ERKIAQQAAKLQGSDLDRTVQQVNQEKQEKQH------------ELDTVVSKIELNRKLIQDQQEQIQHLKSKTN----E 868

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1205 LSRWQVRFDELKEQHQSMDISLTKMDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMESKEQYHEEQKQYID 1284
Cdd:TIGR00606  869 LKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQDKVNDIKE 948

                          810
                   ....*....|....*...
gi 755543021  1285 KLNALRRHKEKLEEKIMD 1302
Cdd:TIGR00606  949 KVKNIHGYMKDIENKIQD 966
HkD_Gipie cd22230
Hook domain found in Gipie (GRP78-interacting protein induced by ER stress) and similar ...
 37-84 3.20e-12

Hook domain found in Gipie (GRP78-interacting protein induced by ER stress) and similar proteins; Gipie, also called coiled-coil domain-containing protein 88B (CCDC88B), or brain leucine zipper domain-containing protein, or Hook-related protein 3 (HkRP3), is a novel actin cytoskeleton-binding protein and Akt substrate that regulates cell migratory responses in various biological contexts. It acts as a positive regulator of T-cell maturation and inflammatory function. As a microtubule-binding protein, Gipie regulates lytic granule clustering and NK cell killing.


Pssm-ID: 411801  Cd Length: 170  Bit Score: 66.78  E-value: 3.20e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 755543021   37 SMEEIKKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEVT 84
Cdd:cd22230   122 AVQELEKLLRLLLGAAVQCERRELFIRHIQGLDLDVQAELAEAIQEVT 169
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 233-923 5.03e-12

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 71.54  E-value: 5.03e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   233 RDELDSLREKAN----RVERLEMDLVRCKEKLHD-VDFYKARMEELREDNIILIETKAMLEEQLTASRARSDKVHEL--- 304
Cdd:TIGR00618  186 FAKKKSLHGKAElltlRSQLLTLCTPCMPDTYHErKQVLEKELKHLREALQQTQQSHAYLTQKREAQEEQLKKQQLLkql 265

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   305 --EKENLQLKSKLHDLELDRDADKKQIEKLLEEYMVLEMAQKQSMKESAHLGWELEQLSK------NADLSDASRKSFVF 376
Cdd:TIGR00618  266 raRIEELRAQEAVLEETQERINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKllmkraAHVKQQSSIEEQRR 345

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   377 ELNECASSRILKLEKENQslQSTIQGLRDTSLALEESSLKYGELEKENQQLSKKIEKLQTQLEREkQSNQDLETLSEELI 456
Cdd:TIGR00618  346 LLQTLHSQEIHIRDAHEV--ATSIREISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQRE-QATIDTRTSAFRDL 422

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   457 R--------EKEQLQSGMEALKADRARQIKDLEQEKGHLHQAVWSLRERPQVNSTKDVekenraLHQAVTEAGSKLSQLE 528
Cdd:TIGR00618  423 QgqlahakkQQELQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQLQTKEQ------IHLQETRKKAVVLARL 496

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   529 LEKQQLHRDLEEAKEKGEQA--------------EALEKELHRLEKENE----QLTKEVTSLKAATEKVEALEHQSQGLE 590
Cdd:TIGR00618  497 LELQEEPCPLCGSCIHPNPArqdidnpgpltrrmQRGEQTYAQLETSEEdvyhQLTSERKQRASLKEQMQEIQQSFSILT 576

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   591 LENRSLRKSLDTLQNVSVQLeglerdkQQLGQENLELRKMVEAmrftsakmaqietENRQLEREKEELRRDVELLKTLSK 670
Cdd:TIGR00618  577 QCDNRSKEDIPNLQNITVRL-------QDLTEKLSEAEDMLAC-------------EQHALLRKLQPEQDLQDVRLHLQQ 636

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   671 KSERLELSYQSVSAENLQLQHslESSTHKSQALQRELSQLEAERQALrrdLETLQLTHKQLEGAEEdrkaleqEVAQLEK 750
Cdd:TIGR00618  637 CSQELALKLTALHALQLTLTQ--ERVREHALSIRVLPKELLASRQLA---LQKMQSEKEQLTYWKE-------MLAQCQT 704

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   751 DKKLLEKEARRLWQQVELKDAILDDSAAKLSAAEKESRALDKELARCRDvgSKLKELEKDNRDLTKQVTMHTRTLTTLRE 830
Cdd:TIGR00618  705 LLRELETHIEEYDREFNEIENASSSLGSDLAAREDALNQSLKELMHQAR--TVLKARTEAHFNNNEEVTAALQTGAELSH 782

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   831 DLVLEKLKSQQLSSELDKLSQELEKVGLSKDLLLQEDDGHGDGKGKTESALKTTLAMKEEKIVFLEAQVEEKESLSRQLQ 910
Cdd:TIGR00618  783 LAAEIQFFNRLREEDTHLLKTLEAEIGQEIPSDEDILNLQCETLVQEEEQFLSRLEEKSATLGEITHQLLKYEECSKQLA 862

                          730
                   ....*....|...
gi 755543021   911 IELQMIKKEHEQL 923
Cdd:TIGR00618  863 QLTQEQAKIIQLS 875
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 176-762 8.34e-12

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 70.54  E-value: 8.34e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   176 ELADTKARLRRVRQELEEKteqlaDTRHEVDQLVLElqkakqdniqlAADARSARAYRDELDSLREKANRVERLEMDLVR 255
Cdd:pfam05557    3 ELIESKARLSQLQNEKKQM-----ELEHKRARIELE-----------KKASALKRQLDRESDRNQELQKRIRLLEKREAE 66

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   256 CKEKLHD-VDFYKARMEELREDNIILIETKAMLEEQLTASRARSDKVHEL----EKENLQLKSKLHDLELDR---DADKK 327
Cdd:pfam05557   67 AEEALREqAELNRLKKKYLEALNKKLNEKESQLADAREVISCLKNELSELrrqiQRAELELQSTNSELEELQerlDLLKA 146

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   328 QIEKLLEEYMVLEMAQkQSMKESAHLGWELEQ-LSKNADLSDASRKSfvfelnECASSRILKLEKENQSLQSTIQGLRdt 406
Cdd:pfam05557  147 KASEAEQLRQNLEKQQ-SSLAEAEQRIKELEFeIQSQEQDSEIVKNS------KSELARIPELEKELERLREHNKHLN-- 217

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   407 slaleesslkygELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEALKA---------DRARQI 477
Cdd:pfam05557  218 ------------ENIENKLLLKEEVEDLKRKLEREEKYREEAATLELEKEKLEQELQSWVKLAQDtglnlrspeDLSRRI 285

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   478 KDLEQEKGHLHQAVWSLRerpqvNSTKDVEKENRalhqavteagsklsQLELEKQQLHRDLEEAKEKGEQAEALEKelhR 557
Cdd:pfam05557  286 EQLQQREIVLKEENSSLT-----SSARQLEKARR--------------ELEQELAQYLKKIEDLNKKLKRHKALVR---R 343

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   558 LEKENEQLTKEVTSLKAATE---KVEALEHQSQGLELENRSLRKSLDTLQ----NVSVQLEGLERD----KQQLGQENLE 626
Cdd:pfam05557  344 LQRRVLLLTKERDGYRAILEsydKELTMSNYSPQLLERIEEAEDMTQKMQahneEMEAQLSVAEEElggyKQQAQTLERE 423

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   627 LRKM-----VEAMRFTSAKMAQIETENRQLEREKEELRRDVEllkTLSKKSERLELSYQSVSAENLQLQHSLESSTHKSQ 701
Cdd:pfam05557  424 LQALrqqesLADPSYSKEEVDSLRRKLETLELERQRLREQKN---ELEMELERRCLQGDYDPKKTKVLHLSMNPAAEAYQ 500

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755543021   702 ALQRELSQLEAERQALRRDLETLQLTHKQLEG-AEEDRKALEQEVAQLEKDKKLLEKEARRL 762
Cdd:pfam05557  501 QRKNQLEKLQAEIERLKRLLKKLEDDLEQVLRlPETTSTMNFKEVLDLRKELESAELKNQRL 562
HkD_Hook cd22222
Hook domain found in Hook family of microtubule-binding proteins; The Hook family includes ...
 37-83 1.25e-11

Hook domain found in Hook family of microtubule-binding proteins; The Hook family includes Hook1-3. Hook1 is a microtubule-binding protein required for spermatid differentiation. Hook2, also a microtubule-binding protein, contributes to the establishment and maintenance of centrosome function. It may function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones. Hook3 is an adaptor protein for microtubule-dependent intracellular vesicle and protein trafficking. It is involved in Golgi and endosome transport. It acts as a scaffold for the opposite-polarity microtubule-based motors cytoplasmic dynein-1 and the kinesin KIF1C. It may participate in the turnover of the endocytosed scavenger receptor. Hook proteins are components of the FTS/Hook/FHIP complex (FHF complex), which may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting (HOPS) complex. Hook adaptor proteins share an N-terminal conserved globular Hook domain, which folds as a variant of the helical calponin homology (CH) domain, and contacts the helix alpha1 of dynein light intermediate chain 1 (LIC1) in a hydrophobic groove.


Pssm-ID: 411793  Cd Length: 147  Bit Score: 64.19  E-value: 1.25e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 755543021   37 SMEEIKKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEV 83
Cdd:cd22222    99 DPKELGRLLQLVLGCAVNCERKEEYIQAIMGLEESVQHVVMEAIQEL 145
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 266-606 1.96e-11

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 69.70  E-value: 1.96e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   266 YKARMEELREDniilietKAMLEEQLTASRArsdKVHELEKENLQLKSKLHDLELDRDADKKQIEKLLEEYMVLEMAQKQ 345
Cdd:TIGR02168  675 RRREIEELEEK-------IEELEEKIAELEK---ALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQ 744

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   346 SMKESAHLGWELEQLSKNADLSDASRKSFVFELNECAS------SRILKLEKENQSLQSTIQGLR-----------DTSL 408
Cdd:TIGR02168  745 LEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAeieeleAQIEQLKEELKALREALDELRaeltllneeaaNLRE 824

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   409 ALEESSLKYGELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEALKADRARQIKDLEQEKGHLH 488
Cdd:TIGR02168  825 RLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELR 904

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   489 qavwslrerpqvnstkDVEKENRALHQAVTEAGSKLSQLELEKQQLHRDLEEAKEK------------GEQAEALEKELH 556
Cdd:TIGR02168  905 ----------------ELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERlseeysltleeaEALENKIEDDEE 968

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....
gi 755543021   557 RLEKENEQLTKEVTSLK----AATEKVEALEHQSQGLELENRSLRKSLDTLQNV 606
Cdd:TIGR02168  969 EARRRLKRLENKIKELGpvnlAAIEEYEELKERYDFLTAQKEDLTEAKETLEEA 1022
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
183-637 2.71e-11

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 68.64  E-value: 2.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  183 RLRRVRQELEEKTEQLADTRHEVDQLVLELQKAKQDNIQLAADARSARAyrdeLDSLREKANRVERLEMDLVRCKEKLhd 262
Cdd:COG4717    75 ELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEK----LLQLLPLYQELEALEAELAELPERL-- 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  263 vDFYKARMEELREdniiLIETKAMLEEQLTasRARSDKVHELEKENLQLKSKLHDLELDRDADKKQIEKLLEEYMVLEMA 342
Cdd:COG4717   149 -EELEERLEELRE----LEEELEELEAELA--ELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEE 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  343 QKQSMKESAHLGWELEQLSKNADLSDASRKSFVFelnecasSRILKLEKENQSLQSTIQGLRDTSLALEE-SSLKYGELE 421
Cdd:COG4717   222 LEELEEELEQLENELEAAALEERLKEARLLLLIA-------AALLALLGLGGSLLSLILTIAGVLFLVLGlLALLFLLLA 294

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  422 KENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEALkADRARQIKDLEQEKGHL-HQAVWSLRERPQV 500
Cdd:COG4717   295 REKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLEL-LDRIEELQELLREAEELeEELQLEELEQEIA 373

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  501 NSTKDVEKENRALHQAVTEAGSKLSQLELEKQQLHRDLEEAkEKGEQAEALEKELHRLEKENEQLTKEvtsLKAATEKVE 580
Cdd:COG4717   374 ALLAEAGVEDEEELRAALEQAEEYQELKEELEELEEQLEEL-LGELEELLEALDEEELEEELEELEEE---LEELEEELE 449

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 755543021  581 ALEHQSQGLELENRSLRKSlDTLQNVSVQLEGLERDKQQLGQENLELRKMVEAMRFT 637
Cdd:COG4717   450 ELREELAELEAELEQLEED-GELAELLQELEELKAELRELAEEWAALKLALELLEEA 505
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
542-1246 3.90e-11

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 68.55  E-value: 3.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  542 KEKGEQAEALEKELHRLEKENEQLtkevtslKAATEKVEALEHQSQGLELENRSLRKSLDtlqNVSVQLEGLERDKQQLG 621
Cdd:PRK03918  172 KEIKRRIERLEKFIKRTENIEELI-------KEKEKELEEVLREINEISSELPELREELE---KLEKEVKELEELKEEIE 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  622 QENLELRKMVEAMRFTSAKMAQIETENRQLEREKEELRRDVELLKTLSKKSErlelsyqsvsaENLQLQHSLESSTHKSQ 701
Cdd:PRK03918  242 ELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKAE-----------EYIKLSEFYEEYLDELR 310

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  702 ALQRELSQLEAERQALRRDLETLQLTHKQLEGAEEDRKALEQEVAQLEKDKKLLEkEARRLWQQVE-----LKDAILDDS 776
Cdd:PRK03918  311 EIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEELEERHELYE-EAKAKKEELErlkkrLTGLTPEKL 389

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  777 AAKLSAAEKESRALDKELarcRDVGSKLKELEKDNRDLTKQVtmhtrtlttlrEDLVLEKLKSQQLSSELDklsqELEKV 856
Cdd:PRK03918  390 EKELEELEKAKEEIEEEI---SKITARIGELKKEIKELKKAI-----------EELKKAKGKCPVCGRELT----EEHRK 451

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  857 GLSKDLLLQEDDghgdgkgktesaLKTTLAMKEEKIVFLEAQVEEKESLsRQLQIELQMIKKEHEQLRQTQEggdkaqna 936
Cdd:PRK03918  452 ELLEEYTAELKR------------IEKELKEIEEKERKLRKELRELEKV-LKKESELIKLKELAEQLKELEE-------- 510

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  937 lkrppgKVTSHQEKEAwepshKEATMELLRVKDRAIELErsnaalqAERQLLKEQLQHLETqnvsfssqiltLQKQSAFL 1016
Cdd:PRK03918  511 ------KLKKYNLEEL-----EKKAEEYEKLKEKLIKLK-------GEIKSLKKELEKLEE-----------LKKKLAEL 561

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1017 QEHTTTLQTQTAKLQVENSTLSSQNAalsaqytvlqsqqaakeaehEGLQQQQEQLAAVYEALLqdhkhlgtlyECQSSE 1096
Cdd:PRK03918  562 EKKLDELEEELAELLKELEELGFESV--------------------EELEERLKELEPFYNEYL----------ELKDAE 611

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1097 YEALIRQHScLKTLHRNLELEHKELGERHGDLQQRKAELEELEKVLSTErealereqktnaiatsENQRLRGELDRISFL 1176
Cdd:PRK03918  612 KELEREEKE-LKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSEE----------------EYEELREEYLELSRE 674

                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1177 HQQLKGEYEELHAHTKELKTSLNNSQLELSrwqvRFDELKEQHQSMDISLTKMDNHCELLSRLKGNLEEE 1246
Cdd:PRK03918  675 LAGLRAELEELEKRREEIKKTLEKLKEELE----EREKAKKELEKLEKALERVEELREKVKKYKALLKER 740
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 183-882 4.05e-11

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 68.61  E-value: 4.05e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   183 RLRRVRQELEEKTEQLADTRHE-VDQLVLELQKAKQDNIQLAADARS-ARAYRDELDSLREKANRVERLEMdlvrckEKL 260
Cdd:pfam15921  246 QLEALKSESQNKIELLLQQHQDrIEQLISEHEVEITGLTEKASSARSqANSIQSQLEIIQEQARNQNSMYM------RQL 319

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   261 HDVDFYKARME-ELREdniilietkamleeqltASRARSDKVHELEKENLQLKSKLHDLELDRDADKK-------QIEKL 332
Cdd:pfam15921  320 SDLESTVSQLRsELRE-----------------AKRMYEDKIEELEKQLVLANSELTEARTERDQFSQesgnlddQLQKL 382

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   333 L------EEYMVLEMAQKQSMkesahlgWELEqlSKNADLSDASRKsfvfELNEcASSRILKLEKENQSLQSTIQGLRDT 406
Cdd:pfam15921  383 LadlhkrEKELSLEKEQNKRL-------WDRD--TGNSITIDHLRR----ELDD-RNMEVQRLEALLKAMKSECQGQMER 448

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   407 SLA--------LEESSLKYGELEKENQQLSKKIEKLQTQ---LEREKQSNQDLETLSEELIREKEQLQSGMEALKAD--- 472
Cdd:pfam15921  449 QMAaiqgknesLEKVSSLTAQLESTKEMLRKVVEELTAKkmtLESSERTVSDLTASLQEKERAIEATNAEITKLRSRvdl 528

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   473 RARQIKDLEQEKGHLhqavwslrerpqvnstKDVEKENRALHQAVTEagsKLSQLELEKQQLHRDLEEAKEKGEQAEALE 552
Cdd:pfam15921  529 KLQELQHLKNEGDHL----------------RNVQTECEALKLQMAE---KDKVIEILRQQIENMTQLVGQHGRTAGAMQ 589

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   553 KELHRLEKENEQLTKEVTSLKAATEKVEAlehqsQGLELENRSLRKSLDTLQNVSVQLEGLeRDKQQLGQENLELRKMVE 632
Cdd:pfam15921  590 VEKAQLEKEINDRRLELQEFKILKDKKDA-----KIRELEARVSDLELEKVKLVNAGSERL-RAVKDIKQERDQLLNEVK 663

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   633 AMRFTSAKMAQ-IETENRQLEREKEELRRDVELLKTLSKKSE-RLELSYQSVSAENLQLQHSLESSTHKSQALQRELSQL 710
Cdd:pfam15921  664 TSRNELNSLSEdYEVLKRNFRNKSEEMETTTNKLKMQLKSAQsELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQI 743

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   711 EAERQALRRDLETLQLTHKQLEGAEEDRKALEQEVAQL--EKDK-----KLLEKEARRLWQQVELKDAILDDSAAKLSAA 783
Cdd:pfam15921  744 DALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELSTVatEKNKmagelEVLRSQERRLKEKVANMEVALDKASLQFAEC 823

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   784 EKESRALDKELARCRDVGS-KLKELE---------------------------KDNRDLTKQVTMHTRTLTTLREDLVLE 835
Cdd:pfam15921  824 QDIIQRQEQESVRLKLQHTlDVKELQgpgytsnssmkprllqpasftrthsnvPSSQSTASFLSHHSRKTNALKEDPTRD 903

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*..
gi 755543021   836 klkSQQLSSELDKLSQELEKVGLSKdlllQEDDGHGDGKGKTESALK 882
Cdd:pfam15921  904 ---LKQLLQELRSVINEEPTVQLSK----AEDKGRAPSLGALDDRVR 943
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
511-1033 5.02e-11

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 68.02  E-value: 5.02e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  511 RALHQAVTEAGSKLSQLElEKQQLHRDLEEAKEKGEQAEALEKELHRLEKEneqltkevTSLKAATEKVEALEHQSQGLE 590
Cdd:COG4913   238 ERAHEALEDAREQIELLE-PIRELAERYAAARERLAELEYLRAALRLWFAQ--------RRLELLEAELEELRAELARLE 308

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  591 LENRSLRKSLDTLQNvsvQLEGLERDKQQLGQENLElrkmveamrftsakmaQIEtenRQLEREKEELRRDVELLKTLSK 670
Cdd:COG4913   309 AELERLEARLDALRE---ELDELEAQIRGNGGDRLE----------------QLE---REIERLERELEERERRRARLEA 366

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  671 KSERLELSYQSVSAE----NLQLQHSLESSTHKSQALQRELSQLEAERQALRRDLETLQLTHKQLEG--------AEEDR 738
Cdd:COG4913   367 LLAALGLPLPASAEEfaalRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERrksniparLLALR 446

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  739 KALEQE----------VAQL----EKDKK---------------LL-----EKEARRL-----------WQQVELKD--- 770
Cdd:COG4913   447 DALAEAlgldeaelpfVGELievrPEEERwrgaiervlggfaltLLvppehYAAALRWvnrlhlrgrlvYERVRTGLpdp 526

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  771 ---AILDDS-AAKLSAAEKESRA-LDKELAR------CRDVgsklKELEKDNRDLTKQVTMHT-RTL------TTLREDL 832
Cdd:COG4913   527 erpRLDPDSlAGKLDFKPHPFRAwLEAELGRrfdyvcVDSP----EELRRHPRAITRAGQVKGnGTRhekddrRRIRSRY 602

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  833 VL-----EKLKS-----QQLSSELDKLSQELEKVGLSKDLLLQEDDGHGDGKGKTESALKttLAMKEEKIVFLEAQVEEK 902
Cdd:COG4913   603 VLgfdnrAKLAAleaelAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEID--VASAEREIAELEAELERL 680

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  903 ESLSrqlqIELQMIKKEHEQLRQTQEGGDKAQNALKRppgKVTSHQEKeawepsHKEATMELLRVKDRAIELErsNAALQ 982
Cdd:COG4913   681 DASS----DDLAALEEQLEELEAELEELEEELDELKG---EIGRLEKE------LEQAEEELDELQDRLEAAE--DLARL 745

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|.
gi 755543021  983 AERQLLKEQLQHLETQNVsfssqiltLQKQSAFLQEHTTTLQTQTAKLQVE 1033
Cdd:COG4913   746 ELRALLEERFAAALGDAV--------ERELRENLEERIDALRARLNRAEEE 788
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 554-1047 6.93e-11

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 67.46  E-value: 6.93e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   554 ELHRLEKENEQLTKEVtslkaateKVEALEHQSQGLELENRSLRKSLDTLQNVSVQLEGLERDKQQLGQENLELRKMVEA 633
Cdd:pfam05557    3 ELIESKARLSQLQNEK--------KQMELEHKRARIELEKKASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALREQ 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   634 MRFTSAKMAQIETENrQLEREKEELRRDVELLKTLSKKserlELSYQSVSAENLQLQhsLESSTHKSQALQRELSQLEAE 713
Cdd:pfam05557   75 AELNRLKKKYLEALN-KKLNEKESQLADAREVISCLKN----ELSELRRQIQRAELE--LQSTNSELEELQERLDLLKAK 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   714 RQALRRDLETLQLTHKQLEGAEEDRKALEQEVAQLEKDKKLLEKEARRLWQQVELkdailddsaaklsaaekesralDKE 793
Cdd:pfam05557  148 ASEAEQLRQNLEKQQSSLAEAEQRIKELEFEIQSQEQDSEIVKNSKSELARIPEL----------------------EKE 205

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   794 LARCRDVGSKLKELEKDNRDLTKQVTMHTRTLTtlREDLVLEKLKSQQLssELDKLSQEL---EKVGLSKDL-------- 862
Cdd:pfam05557  206 LERLREHNKHLNENIENKLLLKEEVEDLKRKLE--REEKYREEAATLEL--EKEKLEQELqswVKLAQDTGLnlrspedl 281

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   863 ------LLQEDDGHGDGKGKTESALK----------TTLAMKEEKIVFLEAQVEEKESLSRQLQIELQMIKKEHEQLRQT 926
Cdd:pfam05557  282 srrieqLQQREIVLKEENSSLTSSARqlekarreleQELAQYLKKIEDLNKKLKRHKALVRRLQRRVLLLTKERDGYRAI 361

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   927 QEGGDKAQNALKrppgkvTSHQEKEAWEpshkEATMELLRVKDRAIELERSNAALQAERQLLKEQLQHLETQNVSFSSQi 1006
Cdd:pfam05557  362 LESYDKELTMSN------YSPQLLERIE----EAEDMTQKMQAHNEEMEAQLSVAEEELGGYKQQAQTLERELQALRQQ- 430

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|.
gi 755543021  1007 lTLQKQSAFLQEHTTTLQTQTAKLQVENSTLSSQNAALSAQ 1047
Cdd:pfam05557  431 -ESLADPSYSKEEVDSLRRKLETLELERQRLREQKNELEME 470
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 466-1217 1.00e-10

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 67.07  E-value: 1.00e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   466 MEALKADRARQIKDLEQ---EKGHLHqavwslrerpqvnstkdvEKENRALHQAVTEAGSKLSQLELEKQQLhrdleeak 542
Cdd:pfam15921   76 IERVLEEYSHQVKDLQRrlnESNELH------------------EKQKFYLRQSVIDLQTKLQEMQMERDAM-------- 129

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   543 ekgeqAEALEKELHRLEKENEQLTKEVTSLKAATE-KVEALEHQSQGLElenrSLRKSLDTLQNVSVQLEGLERDKQQLG 621
Cdd:pfam15921  130 -----ADIRRRESQSQEDLRNQLQNTVHELEAAKClKEDMLEDSNTQIE----QLRKMMLSHEGVLQEIRSILVDFEEAS 200

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   622 QENLELRKMVEAMRFTSAKMA------QIETE-----------NRQLEREKEELRRDVELLktLSKKSERLE--LSYQSV 682
Cdd:pfam15921  201 GKKIYEHDSMSTMHFRSLGSAiskilrELDTEisylkgrifpvEDQLEALKSESQNKIELL--LQQHQDRIEqlISEHEV 278

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   683 SAENLQLQHSLESSTHKSQALQRELSQLEAERQ--ALRRDLETLQLTHKQLEGA-EEDRKALEQEVAQLEKDKKLLEKE- 758
Cdd:pfam15921  279 EITGLTEKASSARSQANSIQSQLEIIQEQARNQnsMYMRQLSDLESTVSQLRSElREAKRMYEDKIEELEKQLVLANSEl 358

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   759 --ARRLWQQVELKDAILDDSAAKLSA----AEKEsRALDKELARC---RDVGSKL------KELEKDNRDLTK------- 816
Cdd:pfam15921  359 teARTERDQFSQESGNLDDQLQKLLAdlhkREKE-LSLEKEQNKRlwdRDTGNSItidhlrRELDDRNMEVQRleallka 437

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   817 -----QVTMHTRTLTTLREDLVLEKLKSqqLSSELDKLSQELEKVG---LSKDLLLQEDDghgdgkgKTESALKTTLAMK 888
Cdd:pfam15921  438 mksecQGQMERQMAAIQGKNESLEKVSS--LTAQLESTKEMLRKVVeelTAKKMTLESSE-------RTVSDLTASLQEK 508

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   889 EEKIVFLEAQVEEKES-LSRQLQiELQMIKKEHEQLRQTQEGGDkaqnALKrppgkvtshqekeaWEPSHKEATMELLRV 967
Cdd:pfam15921  509 ERAIEATNAEITKLRSrVDLKLQ-ELQHLKNEGDHLRNVQTECE----ALK--------------LQMAEKDKVIEILRQ 569

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   968 KDRAI-----ELERSNAALQAERQLLKEQL--QHLETQNVsfssQILTLQKQSAFLQehtttLQTQTAKLQVENSTLssq 1040
Cdd:pfam15921  570 QIENMtqlvgQHGRTAGAMQVEKAQLEKEIndRRLELQEF----KILKDKKDAKIRE-----LEARVSDLELEKVKL--- 637

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1041 naaLSAQYTVLQSQQAAKEaEHEGLQQQQEQLAAVYEALLQDHKHLGTLYECQSSEYEALIRQHSC-LKTLHRNLELEHK 1119
Cdd:pfam15921  638 ---VNAGSERLRAVKDIKQ-ERDQLLNEVKTSRNELNSLSEDYEVLKRNFRNKSEEMETTTNKLKMqLKSAQSELEQTRN 713

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1120 ELGERHG--------------DLQQRKAELEELEKVLSTEREALEREQKTNAIATSENQRLRGELDRISFLHQQLKGEYE 1185
Cdd:pfam15921  714 TLKSMEGsdghamkvamgmqkQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGELE 793

                          810       820       830
                   ....*....|....*....|....*....|..
gi 755543021  1186 ELHAHTKELKTSLNNSQLELSRWQVRFDELKE 1217
Cdd:pfam15921  794 VLRSQERRLKEKVANMEVALDKASLQFAECQD 825
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
416-855 1.03e-10

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 66.71  E-value: 1.03e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  416 KYGELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEALKAdrarQIKDLEQEKGHLHQAVwslr 495
Cdd:COG4717    54 EADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEA----ELEELREELEKLEKLL---- 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  496 erpqvnSTKDVEKENRALHQAVTEAGSKLSQLELEKQQLHRDLEEAKEKGEQAEALEKELHRLEKEN-----EQLTKEVT 570
Cdd:COG4717   126 ------QLLPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLslateEELQDLAE 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  571 SLKAATEKVEALEHQSQGLELENRSLRKSLDTLQNVSVQLEGLERDKQQ---------------LGQENLELRKMVEAMR 635
Cdd:COG4717   200 ELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEArlllliaaallallgLGGSLLSLILTIAGVL 279

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  636 FTSAKMAQIETenRQLEREKEELRRDVELLKTLSKKSERLELSYQSVSAE----NLQLQHSLESSTHKSQALQRELSQLE 711
Cdd:COG4717   280 FLVLGLLALLF--LLLAREKASLGKEAEELQALPALEELEEEELEELLAAlglpPDLSPEELLELLDRIEELQELLREAE 357

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  712 AERQALRRDLETLQLTHKQLEGAEEDRKALEQEVAQLEKDKKLLEkEARRLWQQVElkdAILDDSAAKLSAAEKEsrALD 791
Cdd:COG4717   358 ELEEELQLEELEQEIAALLAEAGVEDEEELRAALEQAEEYQELKE-ELEELEEQLE---ELLGELEELLEALDEE--ELE 431

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755543021  792 KELARCRDvgsKLKELEKDNRDLTKQVTMHTRTLTTLREDLVLEKLKsQQLSSELDKLSQELEK 855
Cdd:COG4717   432 EELEELEE---ELEELEEELEELREELAELEAELEQLEEDGELAELL-QELEELKAELRELAEE 491
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 546-796 1.03e-10

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 65.94  E-value: 1.03e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  546 EQAEALEKELHRLEKENEQLTKEvtsLKAATEKVEALEHQSQGLELENRSLRKSLDTLQNvsvQLEGLERDKQQLGQENL 625
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKE---LAALKKEEKALLKQLAALERRIAALARRIRALEQ---ELAALEAELAELEKEIA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  626 ELRKMVEAMRFTSAKMAqietenRQLEREKeelRRDVELLKTLSKKSERLELSYQSVSAENLQLQHSLESSTHKSQALQR 705
Cdd:COG4942    94 ELRAELEAQKEELAELL------RALYRLG---RQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  706 ELSQLEAERQALRRDLETLQLTHKQLEGAEEDRKALeqeVAQLEKDKKLLEKEARRLWQQVELKDAILDDSAAKLSAAEK 785
Cdd:COG4942   165 LRAELEAERAELEALLAELEEERAALEALKAERQKL---LARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAE 241

                         250
                  ....*....|.
gi 755543021  786 ESRALDKELAR 796
Cdd:COG4942   242 RTPAAGFAALK 252
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
549-999 1.19e-10

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 66.71  E-value: 1.19e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  549 EALEKELHRLEKENEQLTKevtslkAATEKVEALEHQSQGLELENRSLRKSLDTLQNVSVQLEGLERDKQQLGQENLELR 628
Cdd:COG4717    49 ERLEKEADELFKPQGRKPE------LNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLE 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  629 KMVEAmRFTSAKMAQIETENRQLEREKEELRRDVELLKTLSKKSERLElsyqsvsAENLQLQHSLESS-THKSQALQREL 707
Cdd:COG4717   123 KLLQL-LPLYQELEALEAELAELPERLEELEERLEELRELEEELEELE-------AELAELQEELEELlEQLSLATEEEL 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  708 SQLEAERQALRRDLETLQlthKQLEGAEEDRKALEQEVAQLEKDKKLLEKEARRLWQQVELK--DAILDDSAAKLSAAEK 785
Cdd:COG4717   195 QDLAEELEELQQRLAELE---EELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLiaAALLALLGLGGSLLSL 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  786 ESRALDKELARCRDVGSKLKELEKDNRDLTKQvtmhtrtLTTLREDLVLEKLKSQQLSSELDK--LSQELEKVGLSKDL- 862
Cdd:COG4717   272 ILTIAGVLFLVLGLLALLFLLLAREKASLGKE-------AEELQALPALEELEEEELEELLAAlgLPPDLSPEELLELLd 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  863 LLQEDDGHGDGKGKTESALKTTLAMKEEKIVFLEAQVEEKESLSRQLqielqmikKEHEQLRQTQEGGDKAQNALKRPPG 942
Cdd:COG4717   345 RIEELQELLREAEELEEELQLEELEQEIAALLAEAGVEDEEELRAAL--------EQAEEYQELKEELEELEEQLEELLG 416

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 755543021  943 KVTSHQEKEAWEpshkEATMELLRVKDRAIELERSNAALQAERQLLKEQLQHLETQN 999
Cdd:COG4717   417 ELEELLEALDEE----ELEEELEELEEELEELEEELEELREELAELEAELEQLEEDG 469
PTZ00121 PTZ00121
MAEBL; Provisional
 382-1187 1.22e-10

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 67.09  E-value: 1.22e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  382 ASSRILKLEKENQSLQSTIQGLRDTSLALEESSLKYGELEKENQQLSKKIEKlqtqlerekqsnqdlETLSEELIREKEQ 461
Cdd:PTZ00121 1062 AKAHVGQDEGLKPSYKDFDFDAKEDNRADEATEEAFGKAEEAKKTETGKAEE---------------ARKAEEAKKKAED 1126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  462 LQSGMEALKADRARQIKdlEQEKGHLHQAVWSLRerpQVNSTKDVEKENRALHQAVTEAGSKLSQL----ELEKQQLHRD 537
Cdd:PTZ00121 1127 ARKAEEARKAEDARKAE--EARKAEDAKRVEIAR---KAEDARKAEEARKAEDAKKAEAARKAEEVrkaeELRKAEDARK 1201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  538 LEEAKEKGEQAEALEKELHRLEKENEQLTKEVTSLKAATEKVEALEHQSQGLELENRSLRKSLDTLQNVSVQLEglERDK 617
Cdd:PTZ00121 1202 AEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAE--EARK 1279

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  618 QQLGQENLELRKMVEAMRFTSAKMAQIETENRQLEREKEELRRDVELLK----TLSKKSERLELSYQSVSAENLQLQHSL 693
Cdd:PTZ00121 1280 ADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKkkadAAKKKAEEAKKAAEAAKAEAEAAADEA 1359

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  694 ESSTHKSQALQRELSQLEAERQALRRDLETLQLTHKQLEGAEEDRKALEqEVAQLEKDKKLLEkEARRLWQQVELKDAIL 773
Cdd:PTZ00121 1360 EAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKAD-ELKKAAAAKKKAD-EAKKKAEEKKKADEAK 1437

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  774 DDSAAKLSAAEKESRALDKELARcrdvGSKLKELEKDNRDLTKQVTMHTRTLTTLREDLVLEKLKSQQL--SSELDKLSQ 851
Cdd:PTZ00121 1438 KKAEEAKKADEAKKKAEEAKKAE----EAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAkkAAEAKKKAD 1513

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  852 ELEKVglskdlllqEDDGHGDGKGKTESALKTTLAMKEEKivfleaqveekeslsrqlqielqmiKKEHEQLRQTQEggd 931
Cdd:PTZ00121 1514 EAKKA---------EEAKKADEAKKAEEAKKADEAKKAEE-------------------------KKKADELKKAEE--- 1556

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  932 kaqnaLKRPPGKVTSHQEKEAWEpshkeatmellrvkDRAIELERSNAALQAERQLLKEQLQHLETQNVsfssqiltlQK 1011
Cdd:PTZ00121 1557 -----LKKAEEKKKAEEAKKAEE--------------DKNMALRKAEEAKKAEEARIEEVMKLYEEEKK---------MK 1608

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1012 QSAFLQEHTTTLQTQTAKLQVENSTLSSQNAALSAQyTVLQSQQAAKEAEHEGLQQQQeqLAAVYEALLQDHKHLGTLYE 1091
Cdd:PTZ00121 1609 AEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAE-EKKKAEELKKAEEENKIKAAE--EAKKAEEDKKKAEEAKKAEE 1685

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1092 CQSSEYEALIRQHSCLKTLHrnlELEHKELGERHGDLQQRKAELEELEKVLSTEREALEREQKTNAIATSEnqrlrGELD 1171
Cdd:PTZ00121 1686 DEKKAAEALKKEAEEAKKAE---ELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDE-----EEKK 1757

                         810
                  ....*....|....*.
gi 755543021 1172 RISFLHQQLKGEYEEL 1187
Cdd:PTZ00121 1758 KIAHLKKEEEKKAEEI 1773
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 512-759 1.31e-10

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 65.56  E-value: 1.31e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  512 ALHQAVTEAGSKLSQLELEKQQLHRDLEEAKEkgeQAEALEKELHRLEKENEQLTKEvtsLKAATEKVEALEHQSQGLEL 591
Cdd:COG4942    17 AQADAAAEAEAELEQLQQEIAELEKELAALKK---EEKALLKQLAALERRIAALARR---IRALEQELAALEAELAELEK 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  592 ENRSLRKSLDTLQNvsvQLEGLERDKQQLGQENLelrkmvEAMRFTSAKMAQIEtenRQLEREKEELRRDVELLKTLSKK 671
Cdd:COG4942    91 EIAELRAELEAQKE---ELAELLRALYRLGRQPP------LALLLSPEDFLDAV---RRLQYLKYLAPARREQAEELRAD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  672 SERLELSYQSVSAENLQLQHSLEssthKSQALQRELSQLEAERQALRRDLET-LQLTHKQLEGAEEDRKALEQEVAQLEK 750
Cdd:COG4942   159 LAELAALRAELEAERAELEALLA----ELEEERAALEALKAERQKLLARLEKeLAELAAELAELQQEAEELEALIARLEA 234


                  ....*....
gi 755543021  751 DKKLLEKEA 759
Cdd:COG4942   235 EAAAAAERT 243
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 574-816 1.64e-10

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 65.17  E-value: 1.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  574 AATEKVEALEHQSQGLELENRSLRKSLDTLQNVSVQLEG-LERDKQQLGQENLELRKMVEAMRFTSAKMAQIETENRQLE 652
Cdd:COG4942    17 AQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKqLAALERRIAALARRIRALEQELAALEAELAELEKEIAELR 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  653 REKEELRRDVellktlskkSERLELSYQSVSAENLQLqhsLESSTHKSQALqRELSQLEAERQALRRDLETLQLTHKQLE 732
Cdd:COG4942    97 AELEAQKEEL---------AELLRALYRLGRQPPLAL---LLSPEDFLDAV-RRLQYLKYLAPARREQAEELRADLAELA 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  733 gaeEDRKALEQEVAQLEKDKKLLEKEARRLWQQVELKDAILDDSAAKLSAAEKESRALDKELARCRDVGSKLKELEKDNR 812
Cdd:COG4942   164 ---ALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAA 240


                  ....
gi 755543021  813 DLTK 816
Cdd:COG4942   241 ERTP 244
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
626-1292 1.75e-10

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 66.48  E-value: 1.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  626 ELRKMVEAMRFTSAKM---AQIETENRQLEREKEELRRDVELLKTLskKSERLELSYQSVSAENLQLQHSLessthksQA 702
Cdd:COG4913   236 DLERAHEALEDAREQIellEPIRELAERYAAARERLAELEYLRAAL--RLWFAQRRLELLEAELEELRAEL-------AR 306

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  703 LQRELSQLEAERQALRRDLETLQLTHKQLEGAEEDRkaLEQEVAQLEKDKKLLEKEARRLWQQVELKDAILDDSAAKLSA 782
Cdd:COG4913   307 LEAELERLEARLDALREELDELEAQIRGNGGDRLEQ--LEREIERLERELEERERRRARLEALLAALGLPLPASAEEFAA 384

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  783 AEKESRALDKELArcrdvgSKLKELEKDNRDLTKQVTMHTRTLTTLREDL-VLEKLKSQqLSSELDKLSQEL-EKVGLSK 860
Cdd:COG4913   385 LRAEAAALLEALE------EELEALEEALAEAEAALRDLRRELRELEAEIaSLERRKSN-IPARLLALRDALaEALGLDE 457

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  861 -DL-----LLQEDDGHGDGKGKTESAL---KTTLAMKEEKivflEAQVE---EKESLSRQLQIELQMIKKEHEQLRQTQE 928
Cdd:COG4913   458 aELpfvgeLIEVRPEEERWRGAIERVLggfALTLLVPPEH----YAAALrwvNRLHLRGRLVYERVRTGLPDPERPRLDP 533

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  929 GGdkaqnaLkrpPGKVTSHQEkeawePSHKEATMELLRVKDRAI-----ELERSNAALQAERQL-------LKEQLQHLE 996
Cdd:COG4913   534 DS------L---AGKLDFKPH-----PFRAWLEAELGRRFDYVCvdspeELRRHPRAITRAGQVkgngtrhEKDDRRRIR 599

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  997 TQNV---SFSSQILTLQKQSAFLQEHTTTLQTQTAKLQVENSTLSSQNAALSAQYTVLQSQQAAKEAEHEglqqqQEQLA 1073
Cdd:COG4913   600 SRYVlgfDNRAKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVASAERE-----IAELE 674

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1074 AVYEALLQDhkhlgtlyecqSSEYEALIRQHSCLKTLHRNLELEHKELGERHGDLQQRKAELEELEKVLSTEREALEREQ 1153
Cdd:COG4913   675 AELERLDAS-----------SDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLA 743

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1154 KTNAIATSENQRLRGELDRisfLHQQLKgeyEELHAHTKELKTSLNNSQLELSRWQVRFDEL-KEQHQSMDISLTKMDNH 1232
Cdd:COG4913   744 RLELRALLEERFAAALGDA---VERELR---ENLEERIDALRARLNRAEEELERAMRAFNREwPAETADLDADLESLPEY 817

                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755543021 1233 CELLSRLkgnleeENHHLlsqIQLLSQQNQMLLEQNMESKEQYH-------EEQKQYIDKLN-ALRRH 1292
Cdd:COG4913   818 LALLDRL------EEDGL---PEYEERFKELLNENSIEFVADLLsklrraiREIKERIDPLNdSLKRI 876
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 188-548 2.75e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 65.85  E-value: 2.75e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   188 RQELEEKTEQLADTRHEVDQLVLELQKAKQDNIQLAADARSARAYRDELD-SLREKANRVERLEMDLVRCKEKLHDVDFY 266
Cdd:TIGR02168  676 RREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSrQISALRKDLARLEAEVEQLEERIAQLSKE 755

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   267 KARMEELREdniiliETKAMLEEQLTASRARSDKVHELEKENLQLKSKLHDLELDRDADKKQIEKLLEEYMVLEMAQKQS 346
Cdd:TIGR02168  756 LTELEAEIE------ELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESL 829

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   347 MKESAHLGWELEQLSKNAdlsdasrksfvfelnECASSRILKLEKENQSLQSTIQGLRDtslALEESSLKYGELEKENQQ 426
Cdd:TIGR02168  830 ERRIAATERRLEDLEEQI---------------EELSEDIESLAAEIEELEELIEELES---ELEALLNERASLEEALAL 891

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   427 LSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEALKADRARQIKDLEQEkghlhqavWSLRERPQVNSTKDV 506
Cdd:TIGR02168  892 LRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEE--------YSLTLEEAEALENKI 963

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755543021   507 EKENRALHQAVTEAGSKLSQL-------------------ELEKQqlHRDLEEAKEKGEQA 548
Cdd:TIGR02168  964 EDDEEEARRRLKRLENKIKELgpvnlaaieeyeelkerydFLTAQ--KEDLTEAKETLEEA 1022
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 700-939 8.07e-10

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 62.86  E-value: 8.07e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  700 SQALQRELSQLEAERQALRRDLETLQlthKQLEGAEEDRKALEQEVAQLEKDKKLLEKEARRLWQQVELKDAILDDSAAK 779
Cdd:COG4942    15 AAAQADAAAEAEAELEQLQQEIAELE---KELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKE 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  780 LSAAEKESRALDKELARcrdvgsKLKELEKDNRDLTKQVTMHTRTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLS 859
Cdd:COG4942    92 IAELRAELEAQKEELAE------LLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAAL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  860 KDLLLQEDDghgdgkgktesALKTTLAMKEEKIVFLEAQVEEKESLSRQLQIELQMIKKEHEQLRQTQEGGDKAQNALKR 939
Cdd:COG4942   166 RAELEAERA-----------ELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEA 234
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
 637-937 1.55e-09

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 62.39  E-value: 1.55e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   637 TSAKMAQIETENRQLEREKEELRRDVELLK----TLSKKSERLELSYQSVSAENLQLQHSLESSTHKSQALQRELSQLEA 712
Cdd:pfam19220   53 LEALLAQERAAYGKLRRELAGLTRRLSAAEgeleELVARLAKLEAALREAEAAKEELRIELRDKTAQAEALERQLAAETE 132

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   713 ERQALRRDLETLQLthkQLEGAEEDRKALEQEVAQLEKDKKLLEKEARRLWQQVELKDAILDDSAAKLSAAEKesrALDK 792
Cdd:pfam19220  133 QNRALEEENKALRE---EAQAAEKALQRAEGELATARERLALLEQENRRLQALSEEQAAELAELTRRLAELET---QLDA 206

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   793 ELARCRDVGSKLKElekdnrdltkQVTMHTRTLTTLREDLVLEKLKSQQLSSELDKLSQELEkvglSKDLLLQEddghgd 872
Cdd:pfam19220  207 TRARLRALEGQLAA----------EQAERERAEAQLEEAVEAHRAERASLRMKLEALTARAA----ATEQLLAE------ 266

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755543021   873 gkgktesaLKTTLAMKEEKIVFLEAQVEEKESLSRQLQIELQMIKKEHEQLRQTQEGGDKAQNAL 937
Cdd:pfam19220  267 --------ARNQLRDRDEAIRAAERRLKEASIERDTLERRLAGLEADLERRTQQFQEMQRARAEL 323
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
179-767 2.69e-09

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 62.63  E-value: 2.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  179 DTKARLRRVR---QELEEKTEQLADTRHEVDQLvLELQKAKQDNIQLAADARSARAYRDELDSLREKAnRVERLEMDLVR 255
Cdd:COG4913   222 DTFEAADALVehfDDLERAHEALEDAREQIELL-EPIRELAERYAAARERLAELEYLRAALRLWFAQR-RLELLEAELEE 299

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  256 CKEKLHDVDfykARMEELREDniilIETKAMLEEQLTASRARS--DKVHELEKENLQLKSKLHDLELDRDADKKQIekll 333
Cdd:COG4913   300 LRAELARLE---AELERLEAR----LDALREELDELEAQIRGNggDRLEQLEREIERLERELEERERRRARLEALL---- 368

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  334 eeymvlemaqkqsmkesAHLGWELeqlsknadlsDASRKSFVfELNECASSRILKLEKENQSLQSTIQGLRDtslalees 413
Cdd:COG4913   369 -----------------AALGLPL----------PASAEEFA-ALRAEAAALLEALEEELEALEEALAEAEA-------- 412

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  414 slKYGELEKENQQLSKKIEKLqtqleREKQSNqdletLSEELIREKEQLQsgmEALKADRAR--------QIKDLEQ--- 482
Cdd:COG4913   413 --ALRDLRRELRELEAEIASL-----ERRKSN-----IPARLLALRDALA---EALGLDEAElpfvgeliEVRPEEErwr 477

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  483 ----------------EKGHLHQA---VWSLRERPQVNSTKdVEKENRALHQAVTEAGSKLSQLELE--------KQQLH 535
Cdd:COG4913   478 gaiervlggfaltllvPPEHYAAAlrwVNRLHLRGRLVYER-VRTGLPDPERPRLDPDSLAGKLDFKphpfrawlEAELG 556

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  536 R-------DLEEAKEKGEQA-----------EALEKELHRLEKENEQLTKEvtslkaATEKVEALEHQSQGLELEnrslr 597
Cdd:COG4913   557 RrfdyvcvDSPEELRRHPRAitragqvkgngTRHEKDDRRRIRSRYVLGFD------NRAKLAALEAELAELEEE----- 625

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  598 ksldtLQNVSVQLEGLERDKQQLgQENLELRKMVEAMRFTSAKMAQIETENRQLEREKEELRRDVELLKTLSKKSERLEL 677
Cdd:COG4913   626 -----LAEAEERLEALEAELDAL-QERREALQRLAEYSWDEIDVASAEREIAELEAELERLDASSDDLAALEEQLEELEA 699

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  678 SYQsvsaenlQLQHSLESSTHKSQALQRELSQLEAERQALRRDLETL-----QLTHKQLEG--AEEDRKALEQEV-AQLE 749
Cdd:COG4913   700 ELE-------ELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAedlarLELRALLEErfAAALGDAVERELrENLE 772

                         650
                  ....*....|....*...
gi 755543021  750 KDKKLLEKEARRLWQQVE 767
Cdd:COG4913   773 ERIDALRARLNRAEEELE 790
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 174-586 2.73e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 62.39  E-value: 2.73e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   174 AVELADTKARLRRVRQELEEKTEQLADTRHEVDQLVLELQkakqdniqlaadarsaRAYRDELDSLREKANRVERLEMDL 253
Cdd:TIGR02169  669 SRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELS----------------QELSDASRKIGEIEKEIEQLEQEE 732

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   254 VRCKEKLhdvdfykarmEELREDNIILIETKAMLEEQLTASRARSDkvhELEKENLQLKSKLHDLEldRDADKKQIEKLL 333
Cdd:TIGR02169  733 EKLKERL----------EELEEDLSSLEQEIENVKSELKELEARIE---ELEEDLHKLEEALNDLE--ARLSHSRIPEIQ 797

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   334 EEYMVLEMAQKQSMKESAHLGWELEQLSKNADLSDASRKSFVFELNECaSSRILKLEKENQSLQSTIqglRDTSLALEES 413
Cdd:TIGR02169  798 AELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDL-KEQIKSIEKEIENLNGKK---EELEEELEEL 873

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   414 SLKYGELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEALKadraRQIKDLEQEKGHLhqavws 493
Cdd:TIGR02169  874 EAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALE----EELSEIEDPKGED------ 943

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   494 LRERPQVNSTKDVEKENRALHQAVteagsklsqlelekqqlhRDLEEAKEKGEQA-EALEKELHRLEKENEQLTKEVTSL 572
Cdd:TIGR02169  944 EEIPEEELSLEDVQAELQRVEEEI------------------RALEPVNMLAIQEyEEVLKRLDELKEKRAKLEEERKAI 1005

                          410
                   ....*....|....
gi 755543021   573 KAATEKVEALEHQS 586
Cdd:TIGR02169 1006 LERIEEYEKKKREV 1019
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
168-628 3.82e-09

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 61.98  E-value: 3.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  168 EDKQHLAVELADTKARLRRVRQELEEKTEQLADTRHEVDQLVLELQKAKQDNIQLAADARSARAYRDELDSLREKANrvE 247
Cdd:PRK02224  251 EELETLEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELR--D 328

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  248 RLEMDLVRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTASRA----RSDKVHELEKENLQLKSKLHDLELDRD 323
Cdd:PRK02224  329 RLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAREavedRREEIEELEEEIEELRERFGDAPVDLG 408

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  324 ADKKQIEKLLEEymvLEMAQKQSMKESAHLGWELEQLSKNADLSDASR----------KSFVFELNECaSSRILKLEKEN 393
Cdd:PRK02224  409 NAEDFLEELREE---RDELREREAELEATLRTARERVEEAEALLEAGKcpecgqpvegSPHVETIEED-RERVEELEAEL 484

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  394 QSLQSTIQGLRDTSLALEESSlkygELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEA----- 468
Cdd:PRK02224  485 EDLEEEVEEVEERLERAEDLV----EAEDRIERLEERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEEkreaa 560

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  469 ----LKADRARQ-IKDLEQEKGHLHQavwslrERPQVNSTKDVEKENRALHQAVTEAGSKLSQLElEKQQLHRdlEEAKE 543
Cdd:PRK02224  561 aeaeEEAEEAREeVAELNSKLAELKE------RIESLERIRTLLAAIADAEDEIERLREKREALA-ELNDERR--ERLAE 631

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  544 KGEQAEALEKELH--RLEKENEQLTKEVTSLKAATEKVEALEHQSQGL---------ELEN-RSLRKSLDTLQNVSVQLE 611
Cdd:PRK02224  632 KRERKRELEAEFDeaRIEEAREDKERAEEYLEQVEEKLDELREERDDLqaeigavenELEElEELRERREALENRVEALE 711

                         490
                  ....*....|....*..
gi 755543021  612 GLERDKQQLGQENLELR 628
Cdd:PRK02224  712 ALYDEAEELESMYGDLR 728
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 168-585 4.15e-09

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 61.57  E-value: 4.15e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   168 EDKQHLAVELADTKARLRRVRQELEEKTEQLADTRhevdqlvLELQKAKQDNIQLAADARSARAYRDELDSLREkANRVE 247
Cdd:TIGR04523  239 QEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQ-------KELEQNNKKIKELEKQLNQLKSEISDLNNQKE-QDWNK 310

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   248 RLEMDLVRCKEKLHDVDfykarmEELREDNII---LIETKAMLEEQLTASraRSDKVhELEKENLQLKSKLHDLELDRDA 324
Cdd:TIGR04523  311 ELKSELKNQEKKLEEIQ------NQISQNNKIisqLNEQISQLKKELTNS--ESENS-EKQRELEEKQNEIEKLKKENQS 381

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   325 DKKQIEKLLEEYMVLEMAQKQSMKESAHLGWELEQLSKNADLSDASRKSfVFELNECASSRILKLEKENQSLQSTIQGLR 404
Cdd:TIGR04523  382 YKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIER-LKETIIKNNSEIKDLTNQDSVKELIIKNLD 460

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   405 DTSLALEES----SLKYGELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEAL---KADRARQI 477
Cdd:TIGR04523  461 NTRESLETQlkvlSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLeseKKEKESKI 540

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   478 KDLEQEKGHLHQAV-WSLRERPQVNSTKDVEK---ENRALHQAVTEAGSKLSQLELEKQQLHRDLEeakEKGEQAEALEK 553
Cdd:TIGR04523  541 SDLEDELNKDDFELkKENLEKEIDEKNKEIEElkqTQKSLKKKQEEKQELIDQKEKEKKDLIKEIE---EKEKKISSLEK 617

                          410       420       430
                   ....*....|....*....|....*....|..
gi 755543021   554 ELHRLEKENEQLTKEVTSLKAATEKVEALEHQ 585
Cdd:TIGR04523  618 ELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQ 649
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
 184-478 5.67e-09

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 60.86  E-value: 5.67e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   184 LRRVRQELEEKTEQLA----DTRHEVDQLVLELQKAKQDNIQLAADARSARAYRDELDSLREKANRVERLEMDLVRCKEK 259
Cdd:pfam05622   64 LQKQLEQLQEENFRLEtardDYRIKCEELEKEVLELQHRNEELTSLAEEAQALKDEMDILRESSDKVKKLEATVETYKKK 143

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   260 LHDVDFYKARMEELREDNIILIETKAMLEEQLtaSRARSDKVH-ELEKENLQLKSKLHDLELDRdADKKQIE--KLLEEY 336
Cdd:pfam05622  144 LEDLGDLRRQVKLLEERNAEYMQRTLQLEEEL--KKANALRGQlETYKRQVQELHGKLSEESKK-ADKLEFEykKLEEKL 220

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   337 MVLE------MAQKQSMKE-----------SAHLGWELEQLSKNADLSD-ASRKSFVFELNEcassRILKLEKENQSLQS 398
Cdd:pfam05622  221 EALQkekerlIIERDTLREtneelrcaqlqQAELSQADALLSPSSDPGDnLAAEIMPAEIRE----KLIRLQHENKMLRL 296

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   399 TIQGLRDTSLA-----LEESSLKYGELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEAL-KAD 472
Cdd:pfam05622  297 GQEGSYRERLTelqqlLEDANRRKNELETQNRLANQRILELQQQVEELQKALQEQGSKAEDSSLLKQKLEEHLEKLhEAQ 376


                   ....*.
gi 755543021   473 RARQIK 478
Cdd:pfam05622  377 SELQKK 382
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
 384-769 7.00e-09

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 60.64  E-value: 7.00e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   384 SRILKLEKE-----NQSLQSTIQGLRDTSLAlEESSLKYGELEKENQQLSKK----IEKLQTQLE------REKQSNQDL 448
Cdd:pfam06160   10 KEIDELEERknelmNLPVQEELSKVKKLNLT-GETQEKFEEWRKKWDDIVTKslpdIEELLFEAEelndkyRFKKAKKAL 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   449 ETLSEELIREKEQLQSGMEALKadrarQIKDLEQEkghLHQAVWSLRERPQvNSTKDVEKENRALHQAVTEAGSKLSQLE 528
Cdd:pfam06160   89 DEIEELLDDIEEDIKQILEELD-----ELLESEEK---NREEVEELKDKYR-ELRKTLLANRFSYGPAIDELEKQLAEIE 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   529 LEKQQLhrdlEEAKEKG------EQAEALEKELHRLEKENEQ----LTKEVTSLKAATEKVEAL--EHQSQGLELENRSL 596
Cdd:pfam06160  160 EEFSQF----EELTESGdylearEVLEKLEEETDALEELMEDipplYEELKTELPDQLEELKEGyrEMEEEGYALEHLNV 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   597 RKSLDTLQnvsvqlEGLERDKQQLgqENLELRKMVEAMRFTSAkmaQIETENRQLEREKEElRRDVEllktlsKKSERLE 676
Cdd:pfam06160  236 DKEIQQLE------EQLEENLALL--ENLELDEAEEALEEIEE---RIDQLYDLLEKEVDA-KKYVE------KNLPEIE 297

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   677 LSYQSVSAENLQLQHSL----------ESSTHKSQALQRELSQLEAERQALRRDLETLQLTH-----------KQLEGAE 735
Cdd:pfam06160  298 DYLEHAEEQNKELKEELervqqsytlnENELERVRGLEKQLEELEKRYDEIVERLEEKEVAYselqeeleeilEQLEEIE 377

                          410       420       430
                   ....*....|....*....|....*....|....
gi 755543021   736 EDRKALEQEVAQLEKDkkllEKEARRLWQQVELK 769
Cdd:pfam06160  378 EEQEEFKESLQSLRKD----ELEAREKLDEFKLE 407
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 382-583 1.27e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 59.39  E-value: 1.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  382 ASSRILKLEKENQSLQSTIQGLRDtslALEESSLKYGELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQ 461
Cdd:COG4942    18 QADAAAEAEAELEQLQQEIAELEK---ELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAE 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  462 LQSGMEALKADRARQIKDLEQEKGH-----------LHQAVWSLR--------ERPQVNSTKDVEKENRALHQAVTEAGS 522
Cdd:COG4942    95 LRAELEAQKEELAELLRALYRLGRQpplalllspedFLDAVRRLQylkylapaRREQAEELRADLAELAALRAELEAERA 174

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755543021  523 KLSQLELEKQQLHRDLEEAKEKGEQAEA-LEKELHRLEKENEQLTKEVTSLKAATEKVEALE 583
Cdd:COG4942   175 ELEALLAELEEERAALEALKAERQKLLArLEKELAELAAELAELQQEAEELEALIARLEAEA 236
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1546-1922 1.42e-08

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 60.18  E-value: 1.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1546 PPPrnGPVSQETIQKKGAASTHTGVRPHSASPSSEMvtleefleESNRGGSPTHDTPScrddllsdyfrkAHDPPALGGQ 1625
Cdd:PHA03307   71 PPP--GPGTEAPANESRSTPTWSLSTLAPASPAREG--------SPTPPGPSSPDPPP------------PTPPPASPPP 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1626 PGPPARKDGAKMPTSFVAPTIKMSINTSEGQQLKPGHYVkpnlRPSEAEALAGMPSRQVQPPQslslgrprqttmtqnch 1705
Cdd:PHA03307  129 SPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAA----SSRQAALPLSSPEETARAPS----------------- 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1706 mPVSRSASLSRAFSLASADLLRASGPEACRPESPQ-KPGGHEAAGARETSTHSL----QGSHILARERTPIvgkadsPSP 1780
Cdd:PHA03307  188 -SPPAEPPPSTPPAAASPRPPRRSSPISASASSPApAPGRSAADDAGASSSDSSssesSGCGWGPENECPL------PRP 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1781 GQGTrgrpLDTRRFSLAPPK-EERLAPLQQSATAPALATGCSSGSNPqiqHFSPTVAPAVRTKSKVPQHSGEVATVAPvr 1859
Cdd:PHA03307  261 APIT----LPTRIWEASGWNgPSSRPGPASSSSSPRERSPSPSPSSP---GSGPAPSSPRASSSSSSSRESSSSSTSS-- 331

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755543021 1860 pglgTSEGDGGPGhgyseglltKSPGRSSDLPPHVKRGPDDFSQGSSSKSTPASPEPGGDPQT 1922
Cdd:PHA03307  332 ----SSESSRGAA---------VSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAAS 381
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
377-665 2.09e-08

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 59.54  E-value: 2.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  377 ELNECASsRILKLEKENQSLQSTIQGLRDTSLALEESsLKYGELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELi 456
Cdd:COG4913   618 ELAELEE-ELAEAEERLEALEAELDALQERREALQRL-AEYSWDEIDVASAEREIAELEAELERLDASSDDLAALEEQL- 694

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  457 rekEQLQsgmealkadraRQIKDLEQEKGHLHQAVWSLRErpQVNSTKDVEKENRALHQAVTEAGSKLSQLELEkQQLHR 536
Cdd:COG4913   695 ---EELE-----------AELEELEEELDELKGEIGRLEK--ELEQAEEELDELQDRLEAAEDLARLELRALLE-ERFAA 757

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  537 DLEEAKEKgEQAEALEKELHRLEKENEQLTKEVTSLKAATEKVEALEHQSQGLELE-NRSLRKSLDTLQNvsvqlEGLER 615
Cdd:COG4913   758 ALGDAVER-ELRENLEERIDALRARLNRAEEELERAMRAFNREWPAETADLDADLEsLPEYLALLDRLEE-----DGLPE 831

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 755543021  616 DKQQLgqenLELRKmveamRFTSAKMAQIeteNRQLEREKEELRRDVELL 665
Cdd:COG4913   832 YEERF----KELLN-----ENSIEFVADL---LSKLRRAIREIKERIDPL 869
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 394-756 2.17e-08

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 59.68  E-value: 2.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  394 QSLQSTIQGLRDTSLALEESSlKYGELEKENQQLSKkieKLQTQLEREKQ------SNQDLETLSEELIREKEQL--QSG 465
Cdd:PRK10929   48 EALQSALNWLEERKGSLERAK-QYQQVIDNFPKLSA---ELRQQLNNERDeprsvpPNMSTDALEQEILQVSSQLleKSR 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  466 MEALKADRARQIKDleqekghlhqavwSLRERPQVNstkdvekenralhqavTEAGSKLSQLELEKQQLHRD---LEEAK 542
Cdd:PRK10929  124 QAQQEQDRAREISD-------------SLSQLPQQQ----------------TEARRQLNEIERRLQTLGTPntpLAQAQ 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  543 EKGEQAEALEKELHRLEKENEQLT----KEVTSLKAatekvEALEHQSQGLELENRSLRKSLDTL--QNVSVQLEGLERD 616
Cdd:PRK10929  175 LTALQAESAALKALVDELELAQLSannrQELARLRS-----ELAKKRSQQLDAYLQALRNQLNSQrqREAERALESTELL 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  617 KQQLGQ------ENLEL-RKMVEAMRFTSAKMAQIETENRQLEREKEELRRdveLLKTLSKKSERLELSyqSVSAENLQL 689
Cdd:PRK10929  250 AEQSGDlpksivAQFKInRELSQALNQQAQRMDLIASQQRQAASQTLQVRQ---ALNTLREQSQWLGVS--NALGEALRA 324

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755543021  690 QHSLESSTHKSQALQRELSQLEAERQALRRDLETLQlthKQLEGAEEDRKALEQE-----VAQLEKDKKLLE 756
Cdd:PRK10929  325 QVARLPEMPKPQQLDTEMAQLRVQRLRYEDLLNKQP---QLRQIRQADGQPLTAEqnrilDAQLRTQRELLN 393
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
176-582 2.39e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 59.31  E-value: 2.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  176 ELADTKARLRRVRQELEEKTEQLADTRHEVDQLVLELQKAKQDNIQLAADARsarayrdELDSLREKANRVERLEMDLV- 254
Cdd:PRK03918  311 EIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEELEERHE-------LYEEAKAKKEELERLKKRLTg 383

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  255 RCKEKL-HDVDFYKARMEELREDNIILIETKAMLEeqlTASRARSDKVHELEK---------------ENLQLKSK---- 314
Cdd:PRK03918  384 LTPEKLeKELEELEKAKEEIEEEISKITARIGELK---KEIKELKKAIEELKKakgkcpvcgrelteeHRKELLEEytae 460

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  315 LHDLELDRDADKKQIEKLLEEYMVLEMAQKQ-----SMKESAHLGWELEQLSKNADLSDASRKSFVFELNEcasSRILKL 389
Cdd:PRK03918  461 LKRIEKELKEIEEKERKLRKELRELEKVLKKeseliKLKELAEQLKELEEKLKKYNLEELEKKAEEYEKLK---EKLIKL 537

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  390 EKENQSLQSTIQGLRDTSLALEESSLKYGELEKENQQLSKKIEKLQTQLEREKQSN-QDLETLSEELI------REKEQL 462
Cdd:PRK03918  538 KGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELGFESVEELEERlKELEPFYNEYLelkdaeKELERE 617

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  463 QSGMEALKADRARQIKDLEQEKGHLHQAVWSLRERPQVNSTKDVEKENRALHQAVTEAGSKLSQLE-LEKQ--------- 532
Cdd:PRK03918  618 EKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSEEEYEELREEYLELSRELAGLRAELEeLEKRreeikktle 697

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 755543021  533 QLHRDLEEAKEKGEQAEALEKELHRLEKENEQLTKEVTSLK-AATEKVEAL 582
Cdd:PRK03918  698 KLKEELEEREKAKKELEKLEKALERVEELREKVKKYKALLKeRALSKVGEI 748
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 168-675 2.53e-08

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 59.29  E-value: 2.53e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   168 EDKQHLAVELADTKARLRRVRQELEEKTEQLA-------------DTRHEVDQLVLELQKAKQDNIQLAADARSARAYRD 234
Cdd:TIGR00606  591 DRLAKLNKELASLEQNKNHINNELESKEEQLSsyedklfdvcgsqDEESDLERLKEEIEKSSKQRAMLAGATAVYSQFIT 670

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   235 ELD---------------SLREKANRVERLEMDLVRCKEKLHDVDFYKARMEELREDNIILIETKA----MLEEQLTASR 295
Cdd:TIGR00606  671 QLTdenqsccpvcqrvfqTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQsiidLKEKEIPELR 750

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   296 ARSDKV--------HELEKENLQLKSKLHDLELDRD--ADKKQIEKLLEEYMVLE--MAQKQSMKESAHLGWELEQLSKN 363
Cdd:TIGR00606  751 NKLQKVnrdiqrlkNDIEEQETLLGTIMPEEESAKVclTDVTIMERFQMELKDVErkIAQQAAKLQGSDLDRTVQQVNQE 830

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   364 ADLSDASRKSFVFELnECASSRILKLEKENQSLQSTIQGLRDTSLALEESSLKYGELEKENQQLSKKIEKLQTQLEREKQ 443
Cdd:TIGR00606  831 KQEKQHELDTVVSKI-ELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKE 909

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   444 SNQDLETLSEELIREKEQLQSGMEALKADRARQIKDLEQEKGHLHQAVWSLRERPQvnstkdvEKENRALHQAVTEAGSK 523
Cdd:TIGR00606  910 QDSPLETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNIHGYMKDIENKIQ-------DGKDDYLKQKETELNTV 982

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   524 LSQLElEKQQLHRDLEEAKEKGEQAEALEKELHRLEKENEQLTKEVTSLKAATEKV-----EALEHQSQGLELENRSLRK 598
Cdd:TIGR00606  983 NAQLE-ECEKHQEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRENELKEVEEELkqhlkEMGQMQVLQMKQEHQKLEE 1061

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   599 SLDTLQNVSV----QLEGLERDKQQLGQE--NLELRKMVEAMRFTSAKMAQIETENRQLEREKEELrrDVELLKTLSKKS 672
Cdd:TIGR00606 1062 NIDLIKRNHVlalgRQKGYEKEIKHFKKElrEPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTL--DQAIMKFHSMKM 1139


                   ...
gi 755543021   673 ERL 675
Cdd:TIGR00606 1140 EEI 1142
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 959-1315 2.71e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 59.18  E-value: 2.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  959 EATME-LLRVKDRAIELER-----SNAALQAER-QLLKEQLQHLETQnvSFSSQILTLQKQSAflqehttTLQTQTAKLQ 1031
Cdd:COG1196   182 EATEEnLERLEDILGELERqleplERQAEKAERyRELKEELKELEAE--LLLLKLRELEAELE-------ELEAELEELE 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1032 VENSTLSSQNAALSAQYTVLQSQQAAKEAEHEGLQQQQEQLAAVYEALLQDHKHLgtlyecqsseyEALIRQhsclktLH 1111
Cdd:COG1196   253 AELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARL-----------EERRRE------LE 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1112 RNLELEHKELGERHGDLQQRKAELEELEKVLSTEREALEREQKTNAIATSENQRLRGELDRISFLHQQLKGEYEELHAHT 1191
Cdd:COG1196   316 ERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAA 395

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1192 KELKTSLNNSQLELSRWQVRFDELKEQHQSMDISLTKMDnhcELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMES 1271
Cdd:COG1196   396 AELAAQLEELEEAEEALLERLERLEEELEELEEALAELE---EEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEA 472

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 755543021 1272 KEQYHEEQKQYIDKLNALRRHKEKLEEKIMDQYKFYDPAPKKKN 1315
Cdd:COG1196   473 ALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLL 516
PRK01156 PRK01156
chromosome segregation protein; Provisional
 230-741 4.33e-08

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 58.37  E-value: 4.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  230 RAYRDELDSLREKANRVERLEMDLVRCKEKLHDVdfYKARMEElredniilietKAMLEEQLTASRARSDKVHELEKENL 309
Cdd:PRK01156  193 KSSNLELENIKKQIADDEKSHSITLKEIERLSIE--YNNAMDD-----------YNNLKSALNELSSLEDMKNRYESEIK 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  310 QLKSKLHDLELDRDadkkQIEKLLEEYMVLE----MAQKQSMKESAHLGWELEQLSKNADLSDASRKSFvfELNECASSR 385
Cdd:PRK01156  260 TAESDLSMELEKNN----YYKELEERHMKIIndpvYKNRNYINDYFKYKNDIENKKQILSNIDAEINKY--HAIIKKLSV 333

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  386 ILKLEKENQSLQSTIQGLRDTSLALEESSLKYGELEKENQQLSKKIEKLQTQLERekqsnqdletLSEELIREKEQLQSG 465
Cdd:PRK01156  334 LQKDYNDYIKKKSRYDDLNNQILELEGYEMDYNSYLKSIESLKKKIEEYSKNIER----------MSAFISEILKIQEID 403

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  466 MEALKADRA---RQIKDLEQEKGHLHQAVWSLRER-----------------PQVNSTKDVEKENRAlhqaVTEAGSKLS 525
Cdd:PRK01156  404 PDAIKKELNeinVKLQDISSKVSSLNQRIRALRENldelsrnmemlngqsvcPVCGTTLGEEKSNHI----INHYNEKKS 479

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  526 QLELEKQQLHRDLEEAKEK------------GEQAEALEKELHRLEKENEQLTK---EVTSLKAATEKVEALEHQSQGLE 590
Cdd:PRK01156  480 RLEEKIREIEIEVKDIDEKivdlkkrkeyleSEEINKSINEYNKIESARADLEDikiKINELKDKHDKYEEIKNRYKSLK 559

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  591 LENRSLRKSLDTLQNVSVQLEGLERDKQQLGQENLELRKMVEAMR-----------FTSAKMAQIETENRQLE------- 652
Cdd:PRK01156  560 LEDLDSKRTSWLNALAVISLIDIETNRSRSNEIKKQLNDLESRLQeieigfpddksYIDKSIREIENEANNLNnkyneiq 639

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  653 ---REKEELRRDVELLKTLSKKSERLELSYQSVSAENLQLQHSLESSTHKSQALQRELSQLEAERQALR----------- 718
Cdd:PRK01156  640 enkILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKSRKALDDAKANRARLESTIEILRtrinelsdrin 719

                         570       580
                  ....*....|....*....|....*.
gi 755543021  719 ---RDLETLQLTHKQLEGAEEDRKAL 741
Cdd:PRK01156  720 dinETLESMKKIKKAIGDLKRLREAF 745
COG5022 COG5022
Myosin heavy chain [General function prediction only];
339-1137 4.63e-08

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 58.55  E-value: 4.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  339 LEMAQKQSMKESAHLgweleqlsknadLSDASRKSFVFElnecassRILKLEKENQSLQSTIQGLRDTSLALEESSLKYG 418
Cdd:COG5022   736 LEDMRDAKLDNIATR------------IQRAIRGRYLRR-------RYLQALKRIKKIQVIQHGFRLRRLVDYELKWRLF 796

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  419 ELEKENQQLSKK----------IEKLQTQLEREKQSNQDLE------------TLSEELIREKEQLQSGMEALKADRARQ 476
Cdd:COG5022   797 IKLQPLLSLLGSrkeyrsylacIIKLQKTIKREKKLRETEEvefslkaevliqKFGRSLKAKKRFSLLKKETIYLQSAQR 876

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  477 IKDLEQEKGHLHQAVWSLRERPQVNStkdvEKENRALHQAVTEAGSKLSQLELeKQQLHRDLEEAKEKGEQAEALEKELH 556
Cdd:COG5022   877 VELAERQLQELKIDVKSISSLKLVNL----ELESEIIELKKSLSSDLIENLEF-KTELIARLKKLLNNIDLEEGPSIEYV 951

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  557 RLEKENEQLTKEvTSLKAATEKVEAL-----EHQSQGLElENRSLRKSLDTLQNVSVQLEGLERDKQQLGQENLELrkmv 631
Cdd:COG5022   952 KLPELNKLHEVE-SKLKETSEEYEDLlkkstILVREGNK-ANSELKNFKKELAELSKQYGALQESTKQLKELPVEV---- 1025

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  632 eamrftsakmAQIETENRQLEREKEELRRdvelLKTLSKKSERLELSYQSVSAENLQLQhslessthksqaLQRELSQLE 711
Cdd:COG5022  1026 ----------AELQSASKIISSESTELSI----LKPLQKLKGLLLLENNQLQARYKALK------------LRRENSLLD 1079

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  712 AERQALRRDLETLqlthkqlegaeedrkALEQEVAQLEKDKKLLEKEARrlwqqvelKDAILDDSAAKLSAAEKESRALD 791
Cdd:COG5022  1080 DKQLYQLESTENL---------------LKTINVKDLEVTNRNLVKPAN--------VLQFIVAQMIKLNLLQEISKFLS 1136

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  792 KELARCRDVGSKLKELEKDnRDLTKQVTMHTRTLTTLREDLVLEK---------LKSQQLSSELDKLSQELEKV------ 856
Cdd:COG5022  1137 QLVNTLEPVFQKLSVLQLE-LDGLFWEANLEALPSPPPFAALSEKrlyqsalydEKSKLSSSEVNDLKNELIALfskifs 1215

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  857 GLSKDLLLQeddgHGDGKGKTESALKTTL-AMKEEKIVFLEAQVEEKESLSRQLqielqmikKEHEQLRQTQEGGDKAQN 935
Cdd:COG5022  1216 GWPRGDKLK----KLISEGWVPTEYSTSLkGFNNLNKKFDTPASMSNEKLLSLL--------NSIDNLLSSYKLEEEVLP 1283

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  936 ALKR---PPGKVTSHQEKEAWEPSHKeatMELLRVKDRAIELErSNAALQAERQLLKEQLQHLEtqnvsfsSQILTLQKQ 1012
Cdd:COG5022  1284 ATINsllQYINVGLFNALRTKASSLR---WKSATEVNYNSEEL-DDWCREFEISDVDEELEELI-------QAVKVLQLL 1352

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1013 SAFLQEHTTTLQTQTAKLQVENSTLSSQNAALSAQYTVLQSQQAAKEAEheglqQQQEQLAAVYEALLQDHKHLgtlyEC 1092
Cdd:COG5022  1353 KDDLNKLDELLDACYSLNPAEIQNLKSRYDPADKENNLPKEILKKIEAL-----LIKQELQLSLEGKDETEVHL----SE 1423

                         810       820       830       840
                  ....*....|....*....|....*....|....*....|....*
gi 755543021 1093 QSSEYEALIRqhsclktLHRNLELEHKELGERHGDLQQRKAELEE 1137
Cdd:COG5022  1424 IFSEEKSLIS-------LDRNSIYKEEVLSSLSALLTKEKIALLD 1461
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 411-1078 4.85e-08

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 58.31  E-value: 4.85e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   411 EESSLKYGELEK--ENQQLSKKIEKLQTQLEREKQSNQDLETLSEELirekEQLQSGMEALKADRARQIKDLEQEKGHLH 488
Cdd:pfam12128  214 PKSRLNRQQVEHwiRDIQAIAGIMKIRPEFTKLQQEFNTLESAELRL----SHLHFGYKSDETLIASRQEERQETSAELN 289

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   489 QAVWSLRErpQVNSTKD-VEKENRALHQAVTEAGSKLSQLELEKQQ-LHRDLEEAKEKGEQAEALEKELHRLEKENEQLT 566
Cdd:pfam12128  290 QLLRTLDD--QWKEKRDeLNGELSAADAAVAKDRSELEALEDQHGAfLDADIETAAADQEQLPSWQSELENLEERLKALT 367

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   567 KEVTSLKAATEKVEALEHQSQGLELENrsLRKSLDTLQNVSVQLEGLERDKQQlGQENlELRKmveamrftsakmaQIET 646
Cdd:pfam12128  368 GKHQDVTAKYNRRRSKIKEQNNRDIAG--IKDKLAKIREARDRQLAVAEDDLQ-ALES-ELRE-------------QLEA 430

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   647 ENRQLEREKEELRRDVELLKTL----SKKSERLELSYQSVSAENlQLQHSLESSTHKSQALQRELSQLEAER-QALRRdl 721
Cdd:pfam12128  431 GKLEFNEEEYRLKSRLGELKLRlnqaTATPELLLQLENFDERIE-RAREEQEAANAEVERLQSELRQARKRRdQASEA-- 507

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   722 etLQLTHKQL-EGAEEDRKALEQEVAQLEKDKKLLEKEARrLWQQvelkdailddSAAKLSAAEKESRA-LDKELARCRD 799
Cdd:pfam12128  508 --LRQASRRLeERQSALDELELQLFPQAGTLLHFLRKEAP-DWEQ----------SIGKVISPELLHRTdLDPEVWDGSV 574

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   800 --------VGSKLKELE-KDNRDLTKQVTmhtRTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGL-----------S 859
Cdd:pfam12128  575 ggelnlygVKLDLKRIDvPEWAASEEELR---ERLDKAEEALQSAREKQAAAEEQLVQANGELEKASReetfartalknA 651

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   860 KDLLLQEDDGHGDGKGKTESALKTTLAMKEEKIVFLEAQ-----------VEEKESLSRQLQIELQMIKKEHEQLRQTQE 928
Cdd:pfam12128  652 RLDLRRLFDEKQSEKDKKNKALAERKDSANERLNSLEAQlkqldkkhqawLEEQKEQKREARTEKQAYWQVVEGALDAQL 731

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   929 GGDKAQNALKRPPGKVTSHQEKEAWEPSHKEATMELLRVKDRAIELERSNAALQAERQLLKEQLQHLETQNVSFSSQILT 1008
Cdd:pfam12128  732 ALLKAAIAARRSGAKAELKALETWYKRDLASLGVDPDVIAKLKREIRTLERKIERIAVRRQEVLRYFDWYQETWLQRRPR 811

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1009 LQKQSAFLQEHTTTLQTQTAKLQVENSTlssQNAALSAQYTVLQSQQAAKEAEHEGLQQQQEQLAAVYEA 1078
Cdd:pfam12128  812 LATQLSNIERAISELQQQLARLIADTKL---RRAKLEMERKASEKQQVRLSENLRGLRCEMSKLATLKED 878
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 191-1059 4.99e-08

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 58.52  E-value: 4.99e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   191 LEEKTEQLADT-----RHEVDQLVLELQKAKQD----NIQLAADARSARAYRDELDSLREKANRV-----ERLEMDLVRC 256
Cdd:TIGR01612  727 IENKKNELLDIiveikKHIHGEINKDLNKILEDfknkEKELSNKINDYAKEKDELNKYKSKISEIknhynDQINIDNIKD 806

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   257 KEKLHDVDFYKARME--ELREDNI--ILIETKAMLEEQLTasraRSDKVHELE---KENL------------QLKSKLHD 317
Cdd:TIGR01612  807 EDAKQNYDKSKEYIKtiSIKEDEIfkIINEMKFMKDDFLN----KVDKFINFEnncKEKIdseheqfaeltnKIKAEISD 882

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   318 LELDRDADK------------KQIE---------KLLEEYMVLEMAQKQSMKESAHLGWEL-EQLSKNADL---SDASRK 372
Cdd:TIGR01612  883 DKLNDYEKKfndskslineinKSIEeeyqnintlKKVDEYIKICENTKESIEKFHNKQNILkEILNKNIDTikeSNLIEK 962

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   373 SFVFELNECASSRILKLEKenqslqstiqglrdtslALEESSLKygELEKENQQLSKKIEKLQTQLEREKQSnqdleTLS 452
Cdd:TIGR01612  963 SYKDKFDNTLIDKINELDK-----------------AFKDASLN--DYEAKNNELIKYFNDLKANLGKNKEN-----MLY 1018

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   453 EELiREKEQLQSGMEALKADRARQIKDLEQEkghLHQAVWSLRERPQVNSTKDVEKENRALHQAVTEAGSKLSQLElEKQ 532
Cdd:TIGR01612 1019 HQF-DEKEKATNDIEQKIEDANKNIPNIEIA---IHTSIYNIIDEIEKEIGKNIELLNKEILEEAEINITNFNEIK-EKL 1093

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   533 QLHRDLEEAKEkgeqaealekelhrlekENEQLTKEVTSLKAATEKV-EALEHQSQGL-ELENrslrKSLDTLQNVSVQL 610
Cdd:TIGR01612 1094 KHYNFDDFGKE-----------------ENIKYADEINKIKDDIKNLdQKIDHHIKALeEIKK----KSENYIDEIKAQI 1152

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   611 EGLER--DKQQLGQENLELRKMVEAMRFTSAKMAQIETENRQLEREKEELRRDvellKTLSKKSERLELSY-QSVSAENL 687
Cdd:TIGR01612 1153 NDLEDvaDKAISNDDPEEIEKKIENIVTKIDKKKNIYDEIKKLLNEIAEIEKD----KTSLEEVKGINLSYgKNLGKLFL 1228

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   688 -QLQHSLESSTHKSQALQRELSQLE-------------AERQALRRDLETLQLTHKQLEGAEEDRKALEQEVAQL-EKDK 752
Cdd:TIGR01612 1229 eKIDEEKKKSEHMIKAMEAYIEDLDeikekspeienemGIEMDIKAEMETFNISHDDDKDHHIISKKHDENISDIrEKSL 1308

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   753 KLLEKEARrlwqQVELKDaILDDSAAKLSAAEKESRALDKELARCRDVGSKLK----------------ELEKDNRDLTK 816
Cdd:TIGR01612 1309 KIIEDFSE----ESDIND-IKKELQKNLLDAQKHNSDINLYLNEIANIYNILKlnkikkiidevkeytkEIEENNKNIKD 1383

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   817 QVTMHTRTLTTLREDLVLEKLKSQQLSSELDK-LSQELEKVGLSKDLLLQE----------------------------- 866
Cdd:TIGR01612 1384 ELDKSEKLIKKIKDDINLEECKSKIESTLDDKdIDECIKKIKELKNHILSEesnidtyfknadennenvlllfkniemad 1463

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   867 -----------DDGHGD--------------GKGKTESALKTTLAMKEEKIVFLEAQVEEKESLSRQLQIELQmikkehE 921
Cdd:TIGR01612 1464 nksqhilkikkDNATNDhdfninelkehidkSKGCKDEADKNAKAIEKNKELFEQYKKDVTELLNKYSALAIK------N 1537

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   922 QLRQTQEGGDKAQNALKRPPGKVTSHQEKEawEPSHKEATMELLRVKDRAIELERSNAALQAerqlLKEQLQHLETQNVs 1001
Cdd:TIGR01612 1538 KFAKTKKDSEIIIKEIKDAHKKFILEAEKS--EQKIKEIKKEKFRIEDDAAKNDKSNKAAID----IQLSLENFENKFL- 1610

                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1002 fssQILTLQKQSAFLQEHTTTLQTQTAKLQV--ENSTLSSQNAALSAQYTVLQSQQAAKE 1059
Cdd:TIGR01612 1611 ---KISDIKKKINDCLKETESIEKKISSFSIdsQDTELKENGDNLNSLQEFLESLKDQKK 1667
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1456-1872 6.56e-08

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 57.87  E-value: 6.56e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1456 GCNSDDNLCEPSSEPDGPYHRQQASRPNSLESSRNASSNSsplslkGSSDHLHSRCESFSSADLIPSRDPATLSRDGNT- 1534
Cdd:PHA03307   58 GAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAP------ASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPa 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1535 SGRGLLGRHEYPPPRNGPVSQETIQKKGAASTHTGVRPHSASPSSEMVtleeflEESNRGGSPthdtPSCRDDLLSDYFR 1614
Cdd:PHA03307  132 PDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSP------EETARAPSS----PPAEPPPSTPPAA 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1615 KAHDPPALG---GQPGPPARKDGAKMPtSFVAPTIKMSINTSEGQQLKPGhyvkpnlrpSEAEALAGMPSRQVQPPQSLS 1691
Cdd:PHA03307  202 ASPRPPRRSspiSASASSPAPAPGRSA-ADDAGASSSDSSSSESSGCGWG---------PENECPLPRPAPITLPTRIWE 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1692 LGRPrqttmtqncHMPVSRSASLSRAFSLASADLLRASGPEACRPESPQKPGGHEAAGARETSTHSLQGSHILARERTPI 1771
Cdd:PHA03307  272 ASGW---------NGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVS 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1772 VGKADSPSPGQGTRGRPLDTRRFSLAPPKEERLAPLQQSATAPALATGCSSGSNPQIQHFSPTVAPAVRTKSkVPQHSGE 1851
Cdd:PHA03307  343 PGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRP-SPLDAGA 421

                         410       420
                  ....*....|....*....|.
gi 755543021 1852 VATVAPVRPGLGTSEGDGGPG 1872
Cdd:PHA03307  422 ASGAFYARYPLLTPSGEPWPG 442
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 419-999 7.40e-08

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 57.44  E-value: 7.40e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   419 ELEKENQQLSKKIEKLQTQLEREKQSNQDLETlSEELIREKEQLQSGMEALKADRARQIKDLEQEKGHLHQAVWSLRErp 498
Cdd:pfam05557   24 EHKRARIELEKKASALKRQLDRESDRNQELQK-RIRLLEKREAEAEEALREQAELNRLKKKYLEALNKKLNEKESQLA-- 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   499 QVNSTKD-VEKENRALHQAVTEAGSKLSQLELEKQQLHRDLEEAKEKGEQAEALekelhrlekeNEQLTKEVTSLKAATE 577
Cdd:pfam05557  101 DAREVIScLKNELSELRRQIQRAELELQSTNSELEELQERLDLLKAKASEAEQL----------RQNLEKQQSSLAEAEQ 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   578 KVEALEHQSQGLELENRSLRKSLDTLqnvsVQLEGLERDKQQLGQENLELRKMVEAMRFTSAKMAQIETENRQLEREKEE 657
Cdd:pfam05557  171 RIKELEFEIQSQEQDSEIVKNSKSEL----ARIPELEKELERLREHNKHLNENIENKLLLKEEVEDLKRKLEREEKYREE 246

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   658 LrrdvellKTLSKKSERLELSYQSvsAENLQLQHSLESSThkSQALQRELSQLEAERQALRRDLETLQLTHKQLEGAeed 737
Cdd:pfam05557  247 A-------ATLELEKEKLEQELQS--WVKLAQDTGLNLRS--PEDLSRRIEQLQQREIVLKEENSSLTSSARQLEKA--- 312

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   738 RKALEQEVAQ-------LEKDKKLLEKEARRLWQQVELKDAILDDSAAKLSAAEKE---SRALDKELARCRDVGSKLKEL 807
Cdd:pfam05557  313 RRELEQELAQylkkiedLNKKLKRHKALVRRLQRRVLLLTKERDGYRAILESYDKEltmSNYSPQLLERIEEAEDMTQKM 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   808 EKDNRDLTKQVTMHTRTLTTLredlvleKLKSQQLSSELDKLSQelekvglskdlllQEDDGHGDGKGKTESALKttlam 887
Cdd:pfam05557  393 QAHNEEMEAQLSVAEEELGGY-------KQQAQTLERELQALRQ-------------QESLADPSYSKEEVDSLR----- 447

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   888 keEKIVFLEAQVEEKESLSRQLQIELqmikkEHEQLRQTQEGGDKaqnalkrppgKVTSHQEKEAWEpsHKEATMELLRv 967
Cdd:pfam05557  448 --RKLETLELERQRLREQKNELEMEL-----ERRCLQGDYDPKKT----------KVLHLSMNPAAE--AYQQRKNQLE- 507

                          570       580       590
                   ....*....|....*....|....*....|..
gi 755543021   968 kdraielersnaALQAERQLLKEQLQHLETQN 999
Cdd:pfam05557  508 ------------KLQAEIERLKRLLKKLEDDL 527
mukB PRK04863
chromosome partition protein MukB;
440-762 7.44e-08

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 58.04  E-value: 7.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  440 REKQsnqdLETLSEELIREKEQLqsgmealkADRARQIKDLEQEKGHLHQAVWSlreRPQVNSTKDVEKENRALHQAVTE 519
Cdd:PRK04863  784 REKR----IEQLRAEREELAERY--------ATLSFDVQKLQRLHQAFSRFIGS---HLAVAFEADPEAELRQLNRRRVE 848

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  520 AGSKLSQLELEKQQLHRDLEEAKEKGEQAEALEKELHRLekENEQLTKEVTSLKAATEKVEALEH--QSQGLELEnrSLR 597
Cdd:PRK04863  849 LERALADHESQEQQQRSQLEQAKEGLSALNRLLPRLNLL--ADETLADRVEEIREQLDEAEEAKRfvQQHGNALA--QLE 924

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  598 KSLDTLQNVSVQLEGLERDKQQLGQENLELRKMVEAMR--------FTSAKMAQIETENRQLErekEELRRDVELLKTLS 669
Cdd:PRK04863  925 PIVSVLQSDPEQFEQLKQDYQQAQQTQRDAKQQAFALTevvqrrahFSYEDAAEMLAKNSDLN---EKLRQRLEQAEQER 1001

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  670 KKSERLELSYQSVSAENLQLQHSLESS-THKSQ---ALQRELSQL-------EAERQALRRDletlQLtHKQLEGAEEDR 738
Cdd:PRK04863 1002 TRAREQLRQAQAQLAQYNQVLASLKSSyDAKRQmlqELKQELQDLgvpadsgAEERARARRD----EL-HARLSANRSRR 1076

                         330       340
                  ....*....|....*....|....
gi 755543021  739 KALEQEVAQLEKDKKLLEKEARRL 762
Cdd:PRK04863 1077 NQLEKQLTFCEAEMDNLTKKLRKL 1100
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 168-581 7.60e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 57.64  E-value: 7.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  168 EDKQHLAVELADTKARLRRVRQELEEKTEQLADTRHEVDQLVLELQKAKQDNIQLAADARSARAYRDELDSLREKANRVE 247
Cdd:COG1196   400 AQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAAL 479

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  248 RLEMDLVRCKEKLHDVDFYKARMEELREDNIILIETKAMLE--EQLTASRARSDKVHELEKENLQLKSKLHDLELDRDAD 325
Cdd:COG1196   480 AELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRglAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVA 559

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  326 KKQIEKLLE------EYMVLEMAQKQSMKESAHLGWELEQ--LSKNADLSDASRKSFVFELNECASSRI-LKLEKENQSL 396
Cdd:COG1196   560 AAAIEYLKAakagraTFLPLDKIRARAALAAALARGAIGAavDLVASDLREADARYYVLGDTLLGRTLVaARLEAALRRA 639

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  397 QSTIQGLRDTSLALEESSLKYGELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEALKADRARQ 476
Cdd:COG1196   640 VTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEE 719

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  477 IKDLEQEKghlhQAVWSLRERpqvnstkdVEKENRALHQAVTEAGSKLSQLELEKQQLHRDLEEAKEK----G------- 545
Cdd:COG1196   720 ELEEEALE----EQLEAEREE--------LLEELLEEEELLEEEALEELPEPPDLEELERELERLEREiealGpvnllai 787

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 755543021  546 EQAEALEKELHRLEKENEQLTKEVTSLKAATEKVEA 581
Cdd:COG1196   788 EEYEELEERYDFLSEQREDLEEARETLEEAIEEIDR 823
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 513-860 8.38e-08

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 57.21  E-value: 8.38e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   513 LHQAVTEAGSKLSQLELEKQQLHRDLEEAKEKGEQAEALEKELHRLEKENEqltkevTSLKAATEKVEALEHQSQGLELE 592
Cdd:pfam07888   36 LEECLQERAELLQAQEAANRQREKEKERYKRDREQWERQRRELESRVAELK------EELRQSREKHEELEEKYKELSAS 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   593 NRSLRKSLDTLQNVS----VQLEGLERDKQQLGQENL----ELRKMVEAMRFTSAKMAQIETENRQLErekEELRRDVEL 664
Cdd:pfam07888  110 SEELSEEKDALLAQRaaheARIRELEEDIKTLTQRVLeretELERMKERAKKAGAQRKEEEAERKQLQ---AKLQQTEEE 186

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   665 LKTLSKKSERLELSYQSVSAENLQLQHSLESSTHKSQALQRELSQLEAERQALRRDLETLQLTHKQLEG---------AE 735
Cdd:pfam07888  187 LRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRKEAENEALLEELRSLQERLNASERKVEGlgeelssmaAQ 266

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   736 EDRKALEQEVAQLE--------KDKKLLEKEARRLWQQ--------VEL-KDAILDDSAAKLSAAEK------ESRALDK 792
Cdd:pfam07888  267 RDRTQAELHQARLQaaqltlqlADASLALREGRARWAQeretlqqsAEAdKDRIEKLSAELQRLEERlqeermEREKLEV 346

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755543021   793 ELARCRDvgSKLKELEKDNRDLTKQVTmHTRTLTTLREDLVLEKlksQQLSSELDKLSQELEKVGLSK 860
Cdd:pfam07888  347 ELGREKD--CNRVQLSESRRELQELKA-SLRVAQKEKEQLQAEK---QELLEYIRQLEQRLETVADAK 408
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 233-829 8.40e-08

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 57.54  E-value: 8.40e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   233 RDELDSLREKANRVERLEMDLVRCKEKLHDVDFYKARMEELREdniiliETKAMLEEQLTASRArsdkvhelekenlQLK 312
Cdd:pfam12128  240 RPEFTKLQQEFNTLESAELRLSHLHFGYKSDETLIASRQEERQ------ETSAELNQLLRTLDD-------------QWK 300

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   313 SKLHDLELDRDADKKQIEKLLEEYMVLEMAQKQSMKEsahlgwELEQLSKNADLSDasrkSFVFELNEcASSRILKLEKE 392
Cdd:pfam12128  301 EKRDELNGELSAADAAVAKDRSELEALEDQHGAFLDA------DIETAAADQEQLP----SWQSELEN-LEERLKALTGK 369

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   393 NQSLQSTIQGLRdtSLALEESSLKYGELEKENQQLSKKIEKLQTQLE-----REKQSNQDLETLSEELIREKEQLQSGME 467
Cdd:pfam12128  370 HQDVTAKYNRRR--SKIKEQNNRDIAGIKDKLAKIREARDRQLAVAEddlqaLESELREQLEAGKLEFNEEEYRLKSRLG 447

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   468 ALKA--DRARQIKDLEQEKGHLHQAVWSLRERpQVNSTKDVEKENRALHQAVT---EAGSKLSQLELEKQQLHRDLEEAK 542
Cdd:pfam12128  448 ELKLrlNQATATPELLLQLENFDERIERAREE-QEAANAEVERLQSELRQARKrrdQASEALRQASRRLEERQSALDELE 526

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   543 EKGEQA-----EALEKE----------------LHRLE---KENEQLTKEVTSLKAATEKVEALEHQS-----QGLELEN 593
Cdd:pfam12128  527 LQLFPQagtllHFLRKEapdweqsigkvispelLHRTDldpEVWDGSVGGELNLYGVKLDLKRIDVPEwaaseEELRERL 606

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   594 RSLRKSLDTLQNVSVQLEglerdkQQLGQENLELRKMVEAMRFTSAKMAQIETENRQLEREKEELRRD------------ 661
Cdd:pfam12128  607 DKAEEALQSAREKQAAAE------EQLVQANGELEKASREETFARTALKNARLDLRRLFDEKQSEKDKknkalaerkdsa 680

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   662 VELLKTLSKKSERLELSYQSVSAEnlQLQHSLESSTHKSQALQRELSQLEAERQALRRDLETLQLTHK-QLEGAEEDRK- 739
Cdd:pfam12128  681 NERLNSLEAQLKQLDKKHQAWLEE--QKEQKREARTEKQAYWQVVEGALDAQLALLKAAIAARRSGAKaELKALETWYKr 758

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   740 ------ALEQEVAQLEKDKKLLEKEARRL------------WQQvELKDAILDDSAAKLSAAEKESRALDKELAR-CRDV 800
Cdd:pfam12128  759 dlaslgVDPDVIAKLKREIRTLERKIERIavrrqevlryfdWYQ-ETWLQRRPRLATQLSNIERAISELQQQLARlIADT 837

                          650       660
                   ....*....|....*....|....*....
gi 755543021   801 GSKLKELEKDNRDLTKQVTMHTRTLTTLR 829
Cdd:pfam12128  838 KLRRAKLEMERKASEKQQVRLSENLRGLR 866
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 411-723 1.24e-07

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 57.06  E-value: 1.24e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   411 EESSLKYGELEKEnQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQsgmealKADRARQIKDLEQEKGHLHQA 490
Cdd:pfam17380  303 QEKEEKAREVERR-RKLEEAEKARQAEMDRQAAIYAEQERMAMERERELERIR------QEERKRELERIRQEEIAMEIS 375

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   491 VWSLRERPQVNSTKDVEKENRALhqavtEAGSKLSQLELEKQQLHRD--LEEAKEKGEQAEALEKELHRLEKENEQLTKE 568
Cdd:pfam17380  376 RMRELERLQMERQQKNERVRQEL-----EAARKVKILEEERQRKIQQqkVEMEQIRAEQEEARQREVRRLEEERAREMER 450

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   569 VtslkaateKVEALEHQSQgleleNRSLRKSLDTLQNVSVQLEGLERDKQQLGqenlELRKMVEAMRFTSAKMAQIETEN 648
Cdd:pfam17380  451 V--------RLEEQERQQQ-----VERLRQQEEERKRKKLELEKEKRDRKRAE----EQRRKILEKELEERKQAMIEEER 513

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755543021   649 RQLEREKEELRRDVELLKTLSKKSERLELSYQSVSAENLQLQHSLESSTHKsqalQRELSQLEAERQALRRDLET 723
Cdd:pfam17380  514 KRKLLEKEMEERQKAIYEEERRREAEEERRKQQEMEERRRIQEQMRKATEE----RSRLEAMEREREMMRQIVES 584
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 666-1304 1.57e-07

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 56.90  E-value: 1.57e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   666 KTLSKKSERLELSYQSVSaenLQLQHSLESSTHKSQALQRELSQLEAERQALRRDLETLQLTHKQLEGAEEDRKALEQEV 745
Cdd:TIGR00618  190 KSLHGKAELLTLRSQLLT---LCTPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQKREAQEEQLKKQQLLKQLR 266

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   746 AQLEkdkkllekEARRLWQQVELKDAILDDSAAKLSAAEKEsraldKELARCR-DVGSKLKELEKDNRDLTKQVtMHTRT 824
Cdd:TIGR00618  267 ARIE--------ELRAQEAVLEETQERINRARKAAPLAAHI-----KAVTQIEqQAQRIHTELQSKMRSRAKLL-MKRAA 332

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   825 LTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLSKDLLLQEddghgdgkgktesalkttLAMKEEkivfLEAQVEEKES 904
Cdd:TIGR00618  333 HVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQ------------------HTLTQH----IHTLQQQKTT 390

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   905 LSRQLQIELQMIKKEHEqLRQTQEGGDKAQNALKRPpgKVTSHQEKEawePSHKEATMELLRVKDRAIELERSNAALQAE 984
Cdd:TIGR00618  391 LTQKLQSLCKELDILQR-EQATIDTRTSAFRDLQGQ--LAHAKKQQE---LQQRYAELCAAAITCTAQCEKLEKIHLQES 464

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   985 RQLLKEQLQHLETQNVSFSSQILTLQKQSAFLQEHtttlqtQTAKLQVENSTLS-SQNAALSAQYTVLQSQQAAKEAEHE 1063
Cdd:TIGR00618  465 AQSLKEREQQLQTKEQIHLQETRKKAVVLARLLEL------QEEPCPLCGSCIHpNPARQDIDNPGPLTRRMQRGEQTYA 538

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1064 GLQQQqeqLAAVYEALLQDHKHLGTLYECQSSEYEALIRQHSCLKTLHRNLELEHKELGerhgDLQQRKAELEELEKVLS 1143
Cdd:TIGR00618  539 QLETS---EEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITV----RLQDLTEKLSEAEDMLA 611

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1144 TEREALEREQKTNAiatsENQRLRGELDRISFLHQQLK---GEYEELHAHTKELKTSLNNSQLELSRWQVRFDELKEQhQ 1220
Cdd:TIGR00618  612 CEQHALLRKLQPEQ----DLQDVRLHLQQCSQELALKLtalHALQLTLTQERVREHALSIRVLPKELLASRQLALQKM-Q 686

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1221 SMDISLT---KMDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMESKEQYHEE-QKQYIDKLNALRR-HKEK 1295
Cdd:TIGR00618  687 SEKEQLTywkEMLAQCQTLLRELETHIEEYDREFNEIENASSSLGSDLAAREDALNQSLKElMHQARTVLKARTEaHFNN 766


                   ....*....
gi 755543021  1296 LEEKIMDQY 1304
Cdd:TIGR00618  767 NEEVTAALQ 775
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 843-1300 1.64e-07

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 56.52  E-value: 1.64e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   843 SSELDKLSQELEKVGLSKDLLLQEDDGHGDGKGKTESALKTTLAMK---EEKIVFLEAQVEEKESLSRQLQIELQMIKKE 919
Cdd:TIGR00618  162 SKEKKELLMNLFPLDQYTQLALMEFAKKKSLHGKAELLTLRSQLLTlctPCMPDTYHERKQVLEKELKHLREALQQTQQS 241

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   920 HEQLRQTQEGGDKAQNALKRPPGKVTSHQEKEAWEPSHKEATMELLRVKDRAIELERSNAALQAERQLlkeqlqhletqn 999
Cdd:TIGR00618  242 HAYLTQKREAQEEQLKKQQLLKQLRARIEELRAQEAVLEETQERINRARKAAPLAAHIKAVTQIEQQA------------ 309

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1000 vsfssqiltlqkqsaflQEHTTTLQTQTAKLqvenstlssqnAALSAQYTVLQSQQAAKEAEHEGLqqqqeqlaavyEAL 1079
Cdd:TIGR00618  310 -----------------QRIHTELQSKMRSR-----------AKLLMKRAAHVKQQSSIEEQRRLL-----------QTL 350

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1080 LQDHKHLGtlyecQSSEYEALIRQHSClktlhrnlelEHKELGERHGDLQQRKAELEELEKVLSTEREALEREQKTNAIA 1159
Cdd:TIGR00618  351 HSQEIHIR-----DAHEVATSIREISC----------QQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQATIDTR 415

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1160 TSENQRLRGELDRISFLHQQLKGEYEELHAHTKELKTSLNNSQLELSRWQVRFDELKEQHQSMDISLTKMDN----HCEL 1235
Cdd:TIGR00618  416 TSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQLQTKEQIHLQETRkkavVLAR 495

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1236 LSRLKGN---LEEENHHLLSQIQLL--SQQNQMLLEQNMESKEQYHEEQKQYIDKLNALRRHKEKLEEKI 1300
Cdd:TIGR00618  496 LLELQEEpcpLCGSCIHPNPARQDIdnPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQM 565
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 640-818 1.96e-07

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 54.16  E-value: 1.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  640 KMAQIETENRQLEREKEELRRDVELLKtlskksERLElsyqsvsaenlQLQHSLESSTHKSQALQRELSQLEAERQALRR 719
Cdd:COG1579    11 DLQELDSELDRLEHRLKELPAELAELE------DELA-----------ALEARLEAAKTELEDLEKEIKRLELEIEEVEA 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  720 DLETLQlthKQLEGA--EEDRKALEQEVAQLEKDKKLLEKEARRLWQQVELKDAILDDSAAKLSAAEKESRALDKEL-AR 796
Cdd:COG1579    74 RIKKYE---EQLGNVrnNKEYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELdEE 150

                         170       180
                  ....*....|....*....|..
gi 755543021  797 CRDVGSKLKELEKDNRDLTKQV 818
Cdd:COG1579   151 LAELEAELEELEAEREELAAKI 172
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
664-1125 2.63e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 55.54  E-value: 2.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  664 LLKTLSKKSERLELSYQSVSAENLQLQHSLESSTHKSQALQRELSQLEAERQALRRDLETLQlthKQLEGAEEDRKALEQ 743
Cdd:COG4717    47 LLERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELE---AELEELREELEKLEK 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  744 EVAQLEKDKKLLEKEARRLWQQVELKDaiLDDSAAKLSAAEKESRALDKELARCRDVGSKLKEL-----EKDNRDLTKQV 818
Cdd:COG4717   124 LLQLLPLYQELEALEAELAELPERLEE--LEERLEELRELEEELEELEAELAELQEELEELLEQlslatEEELQDLAEEL 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  819 TMHTRTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLSKDL---------------LLQEDDGHGDGKGKTESALKT 883
Cdd:COG4717   202 EELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLkearlllliaaallaLLGLGGSLLSLILTIAGVLFL 281

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  884 TLAmkeekIVFLEAQVEEKESLSRQLQIELQMIKKEHEQLRQTQEGGDKAQNALKrppgkvtshqekeawEPSHKEATME 963
Cdd:COG4717   282 VLG-----LLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLP---------------PDLSPEELLE 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  964 LLRVKDRAIELERSNAALQAERQL---LKEQLQHLETQNVSFSSQILTLQKQSAFLQEHTTTLQTQTAKLQVENSTLSSQ 1040
Cdd:COG4717   342 LLDRIEELQELLREAEELEEELQLeelEQEIAALLAEAGVEDEEELRAALEQAEEYQELKEELEELEEQLEELLGELEEL 421

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1041 NAA-----LSAQYTVLQSQQAAKEAEHEGLQQQQEQLAAVYEALLQDHK--HLGTLYECQSSEYEALIRQHSCLKTLHRN 1113
Cdd:COG4717   422 LEAldeeeLEEELEELEEELEELEEELEELREELAELEAELEQLEEDGElaELLQELEELKAELRELAEEWAALKLALEL 501

                         490
                  ....*....|..
gi 755543021 1114 LELEHKELGERH 1125
Cdd:COG4717   502 LEEAREEYREER 513
HOOK_N pfam19047
HOOK domain; This domain is found at the N-terminus of HOOK proteins.
 39-83 2.65e-07

HOOK domain; This domain is found at the N-terminus of HOOK proteins.


Pssm-ID: 465958  Cd Length: 151  Bit Score: 52.02  E-value: 2.65e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 755543021    39 EEIKKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEV 83
Cdd:pfam19047  103 AELGRLLQLILGCAVNCEKKQEYIQQIMTLEESVQHVVMTAIQEL 147
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
712-1154 2.84e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 55.54  E-value: 2.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  712 AERQALRRDLETLQLTHKQLEGAEEDRKALEQEVAQLEKDKKLLEKEARRLWQQVELKDAIlddsaAKLSAAEKESRALD 791
Cdd:COG4717    71 KELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLY-----QELEALEAELAELP 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  792 KELARCRDVGSKLKELEKDNRDLTKQVTMHTRTLTTLREDLVLEKLKS-QQLSSELDKLSQELEkvglskdlllqeddgh 870
Cdd:COG4717   146 ERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEElQDLAEELEELQQRLA---------------- 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  871 gdgkgktesALKTTLAMKEEKIVFLEAQVEEKESLSRQLQIELQmIKKEHEQLRQT------QEGGDKAQNALKRPPGKV 944
Cdd:COG4717   210 ---------ELEEELEEAQEELEELEEELEQLENELEAAALEER-LKEARLLLLIAaallalLGLGGSLLSLILTIAGVL 279

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  945 TSHQEKEAWEPSHKE-ATMELLRVKDRAIELERSNAALQAERQLLKEQLQHLETQNVSFSSQILTLQKQsafLQEHTTTL 1023
Cdd:COG4717   280 FLVLGLLALLFLLLArEKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEE---LQELLREA 356

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1024 QTQTAKLQVENstLSSQNAALsaqytvLQSQQAAKEAEHEGLQQQQEQlaavYEALLQDHKHLGTLYECQSSEYEALIRQ 1103
Cdd:COG4717   357 EELEEELQLEE--LEQEIAAL------LAEAGVEDEEELRAALEQAEE----YQELKEELEELEEQLEELLGELEELLEA 424

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 755543021 1104 HSC--LKTLHRNLELEHKELGERHGDLQQRKAELEELEKVLSTEREALEREQK 1154
Cdd:COG4717   425 LDEeeLEEELEELEEELEELEEELEELREELAELEAELEQLEEDGELAELLQE 477
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1546-1922 6.40e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.94  E-value: 6.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1546 PPPRNGPVSQETiqKKGAASTHTGVRPHSASPSSEMVTLEEFLEESNRGGSPTHDTPScrddllsdyfrkahDPPAlggq 1625
Cdd:PHA03247 2569 PPPRPAPRPSEP--AVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAP--------------DPPP---- 2628

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1626 PGPPARKDGAKMPTSFVAPTIKMSINTSEGQQLKPGHYVKPNLRPSEAEALAGMPSRQVQPPQ--SL-SLGRPRQTTMTq 1702
Cdd:PHA03247 2629 PSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTvgSLtSLADPPPPPPT- 2707

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1703 nchmPVSRSASLSRAFSLASadllrasGPEACRPESPQKPGgheAAGARETSTHSLQGSHILARERTPIVGKADSPSPGQ 1782
Cdd:PHA03247 2708 ----PEPAPHALVSATPLPP-------GPAAARQASPALPA---APAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPA 2773

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1783 GTRGRPLDTrrfsLAPPKEERLAPLQQSATAPALATGCSSGSNPQIQHFSPTVAPAvrtkSKVPQHSGEVATVAPVRPG- 1861
Cdd:PHA03247 2774 APAAGPPRR----LTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPA----GPLPPPTSAQPTAPPPPPGp 2845

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755543021 1862 LGTSEGDGG---PGHGYSEGLLTKSPGRSSDLPPH----------VKRGPDDFSQGSSSKSTPASPEPGGDPQT 1922
Cdd:PHA03247 2846 PPPSLPLGGsvaPGGDVRRRPPSRSPAAKPAAPARppvrrlarpaVSRSTESFALPPDQPERPPQPQAPPPPQP 2919
Macoilin pfam09726
Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 ...
 386-634 7.36e-07

Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 trasnmembrane helices, followed by a C-terminal coiled-coil region. Macoilin is a highly conserved protein present in eukaryotes. Macoilin appears to be found in the ER and be involved in the function of neurons.


Pssm-ID: 462859 [Multi-domain]  Cd Length: 670  Bit Score: 54.47  E-value: 7.36e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   386 ILKLEKENQSLQSTIQGLRD--TSLALEESSLK--YGELEKENQQLSKKIEKLQTQLEREKQSNQDLEtlsEELIREKEQ 461
Cdd:pfam09726  404 IKKLKAELQASRQTEQELRSqiSSLTSLERSLKseLGQLRQENDLLQTKLHNAVSAKQKDKQTVQQLE---KRLKAEQEA 480

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   462 LQSGMEALKADRARQIKDLEQEKGHLHQAVWSLRERpqvnstkdvekenralhqavTEA-GSKLSQLELEKQQLHRDLEE 540
Cdd:pfam09726  481 RASAEKQLAEEKKRKKEEEATAARAVALAAASRGEC--------------------TESlKQRKRELESEIKKLTHDIKL 540

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   541 AKEKGEQAEALEKELHRLeKENEQLTKEVTS-LKAATEKVEALEHQsqgLELENRSLRKSLDTLQNVSVQLEGLERDKQQ 619
Cdd:pfam09726  541 KEEQIRELEIKVQELRKY-KESEKDTEVLMSaLSAMQDKNQHLENS---LSAETRIKLDLFSALGDAKRQLEIAQGQIYQ 616

                          250
                   ....*....|....*.
gi 755543021   620 LGQENLELR-KMVEAM 634
Cdd:pfam09726  617 KDQEIKDLKqKIAEVM 632
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 529-923 8.77e-07

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 54.29  E-value: 8.77e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  529 LEKQQLHRDLEEAK-----EKGEQAEALEKELHRLE--KENEQ--------------LTKEVTS-LKAATEKVEALEHQS 586
Cdd:PRK10929   23 PDEKQITQELEQAKaaktpAQAEIVEALQSALNWLEerKGSLErakqyqqvidnfpkLSAELRQqLNNERDEPRSVPPNM 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  587 QGLELENRSLRksldtlqnVSVQLEGLERdkqQLGQENLELRKMVEAMrftsAKMAQIETENRQLEREKEelRRdvelLK 666
Cdd:PRK10929  103 STDALEQEILQ--------VSSQLLEKSR---QAQQEQDRAREISDSL----SQLPQQQTEARRQLNEIE--RR----LQ 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  667 TLSKKSERLElsyqsvSAENLQLQhsLESSTHKSQALQRELSQLEAE-RQALRR-DLETLQLTHKQLEGAEEDRK----A 740
Cdd:PRK10929  162 TLGTPNTPLA------QAQLTALQ--AESAALKALVDELELAQLSANnRQELARlRSELAKKRSQQLDAYLQALRnqlnS 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  741 LEQEVAQ--LEKDKKLLEKEArrlwqqvELKDAILDdsaaKLSAAEKESRALDKELARCRDVGSKlkelekdNRDLTKQV 818
Cdd:PRK10929  234 QRQREAEraLESTELLAEQSG-------DLPKSIVA----QFKINRELSQALNQQAQRMDLIASQ-------QRQAASQT 295

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  819 TMHTRTLTTLRE--------DLVLEKL-----------KSQQLSSELDKLSQE-------LEKvgLSKDLLLQEDDGhgd 872
Cdd:PRK10929  296 LQVRQALNTLREqsqwlgvsNALGEALraqvarlpempKPQQLDTEMAQLRVQrlryedlLNK--QPQLRQIRQADG--- 370

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 755543021  873 gkgktesalkTTLAMKEEKIvfLEAQVEEKESLSRQL------QI-ELQMIKKEHEQL 923
Cdd:PRK10929  371 ----------QPLTAEQNRI--LDAQLRTQRELLNSLlsggdtLIlELTKLKVANSQL 416
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 696-855 9.15e-07

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 52.23  E-value: 9.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  696 STHKSQALQRELSQLEAERQALRRDLETLQlthKQLEGAEEDRKALEQEVAQLEKDKKLLEKEARRLWQQVELKDAILDD 775
Cdd:COG1579     1 AMPEDLRALLDLQELDSELDRLEHRLKELP---AELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  776 SAAKLSAA--EKESRALDKELARCRDvgsKLKELEKDNRDLTKQVTMHTRTLTTLREDLVLEKLKSQQLSSELDKLSQEL 853
Cdd:COG1579    78 YEEQLGNVrnNKEYEALQKEIESLKR---RISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAEL 154


                  ..
gi 755543021  854 EK 855
Cdd:COG1579   155 EA 156
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
428-757 9.57e-07

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 53.87  E-value: 9.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  428 SKKIEKLQTQLEREKQSNQDLETlseelirEKEQLQSGMEALKA-DRARQIKDLEQEKGHLHQAVWSLRERPQVNSTKD- 505
Cdd:COG3206    63 PQSSDVLLSGLSSLSASDSPLET-------QIEILKSRPVLERVvDKLNLDEDPLGEEASREAAIERLRKNLTVEPVKGs 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  506 ------VEKENRALHQAVTEAgskLSQLELEkQQLHRDLEEAKEkgeQAEALEKELHRLEKENEQLTKEVTSLKAATeKV 579
Cdd:COG3206   136 nvieisYTSPDPELAAAVANA---LAEAYLE-QNLELRREEARK---ALEFLEEQLPELRKELEEAEAALEEFRQKN-GL 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  580 EALEHQSQGLELENRSLRKSLDTLQnvsVQLEGLERDKQQLgQENLELRKMVEAMRFTSAKMAQIETENRQLEREKEELR 659
Cdd:COG3206   208 VDLSEEAKLLLQQLSELESQLAEAR---AELAEAEARLAAL-RAQLGSGPDALPELLQSPVIQQLRAQLAELEAELAELS 283

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  660 RdvellkTLSKKSERlelsYQSVSAENLQLQHSLEssthksQALQRELSQLEAERQALRRDLETLQLTHKQLEGAEEDRK 739
Cdd:COG3206   284 A------RYTPNHPD----VIALRAQIAALRAQLQ------QEAQRILASLEAELEALQAREASLQAQLAQLEARLAELP 347

                         330
                  ....*....|....*...
gi 755543021  740 ALEQEVAQLEKDKKLLEK 757
Cdd:COG3206   348 ELEAELRRLEREVEVARE 365
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1362-1862 1.05e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.17  E-value: 1.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1362 ALRSQTENPDNPPSGPNcveerdthngpvGKGPGDlkpKRGSPRGGSVDRTDTSTDPAVKSWPSEPGSRTFSTSATTAAL 1441
Cdd:PHA03247 2581 AVTSRARRPDAPPQSAR------------PRAPVD---DRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPT 2645

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1442 S------SSTPIPKHLGRTKGCNSDDNLCEPSSEPDGPyhRQQASRP------NSLESSRNASSNSSPLSLKGSSDHLHS 1509
Cdd:PHA03247 2646 VppperpRDDPAPGRVSRPRRARRLGRAAQASSPPQRP--RRRAARPtvgsltSLADPPPPPPTPEPAPHALVSATPLPP 2723

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1510 RCESFSSADLIPSRDPATlsrdgntsgrgllgrheyPPPRNGPVSQETIQKKGAASTHTGvrPHSASPSSEmvtleefle 1589
Cdd:PHA03247 2724 GPAAARQASPALPAAPAP------------------PAVPAGPATPGGPARPARPPTTAG--PPAPAPPAA--------- 2774

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1590 esnRGGSPTHDTPSCRDDLLSDYFRKAHDPPALGGQPGPPARKDGAKMPTSFVAPTIKMSINTSEGQQLKPGHYVKPNLr 1669
Cdd:PHA03247 2775 ---PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSL- 2850

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1670 PSEAEALAGMPSRQVQPPqslslgRPRQTTMTQNCHMPVSRsaslsrafsLASADLLRASGPEACRPESPQKPGGHEAAG 1749
Cdd:PHA03247 2851 PLGGSVAPGGDVRRRPPS------RSPAAKPAAPARPPVRR---------LARPAVSRSTESFALPPDQPERPPQPQAPP 2915

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1750 ARETsthslqgshilarerTPIVGKADSPSPGQGTRGRPldtrrfslAPPkeerLAPLQQSATAPALATGCSsgsNPQIQ 1829
Cdd:PHA03247 2916 PPQP---------------QPQPPPPPQPQPPPPPPPRP--------QPP----LAPTTDPAGAGEPSGAVP---QPWLG 2965

                         490       500       510
                  ....*....|....*....|....*....|...
gi 755543021 1830 HFSPTVAPAVRTksKVPQHSGEVATVAPVRPGL 1862
Cdd:PHA03247 2966 ALVPGRVAVPRF--RVPQPAPSREAPASSTPPL 2996
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 176-544 1.05e-06

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 53.87  E-value: 1.05e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   176 ELADTKARLRRVRQELE----EKTEQLADTRHEVDQLVLELQKAKQDNIQLAADARSARAYRDELDSL-REKANRVERLE 250
Cdd:TIGR04523  339 QLNEQISQLKKELTNSEsensEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLnQQKDEQIKKLQ 418

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   251 MDlvrcKEKLhdvdfyKARMEELREDNIILIETkamleeqltasrarsdkVHELEKENLQLKSKLHDLELDRDADKKQIE 330
Cdd:TIGR04523  419 QE----KELL------EKEIERLKETIIKNNSE-----------------IKDLTNQDSVKELIIKNLDNTRESLETQLK 471

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   331 KLLEEYMVLEMAQKQSMKESAHLGWELEQLSKNADLSDASRKSFVFELNEcASSRILKLEKENQSLQSTIQGLRDTSLAL 410
Cdd:TIGR04523  472 VLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISS-LKEKIEKLESEKKEKESKISDLEDELNKD 550

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   411 EeSSLKYGELEKENQQLSKKIEKLQTQLEREKQSNQDLEtlseELIREKEQlqsgmealkadrarQIKDLEQEKGHLHQA 490
Cdd:TIGR04523  551 D-FELKKENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQ----ELIDQKEK--------------EKKDLIKEIEEKEKK 611

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....
gi 755543021   491 VWSLRERpqvnsTKDVEKENRALHQAVTEAGSKLSQLELEKQQLHRDLEEAKEK 544
Cdd:TIGR04523  612 ISSLEKE-----LEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIRNK 660
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 636-855 1.14e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 53.23  E-value: 1.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  636 FTSAKMAQIETENRQLEREKEELRRDVELLKTLSKKSERLELSYQSVSAENLQLQHSLESSTHKSQALQRELSQLEAERQ 715
Cdd:COG4942    14 AAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  716 ALRRDLETLQ------LTHKQLEGAEEDRKAL--EQEVAQLEKDKKLLEKEARRLWQQVELKDAILDDSAAKLSAAEKES 787
Cdd:COG4942    94 ELRAELEAQKeelaelLRALYRLGRQPPLALLlsPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAER 173

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755543021  788 RALDKELARcrdVGSKLKELEKDNRDLTKQVTMHTRTLTTLREDLVLEKLKSQQLSSELDKLSQELEK 855
Cdd:COG4942   174 AELEALLAE---LEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAA 238
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 528-1187 1.15e-06

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 54.03  E-value: 1.15e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   528 ELEKQQLHRDLEEAKEKGEQAEaleKELHRLEKENEQLTKEVT----SLKAATEKVEALEHQSQGLELENRSLRkslDTL 603
Cdd:pfam01576    4 EEEMQAKEEELQKVKERQQKAE---SELKELEKKHQQLCEEKNalqeQLQAETELCAEAEEMRARLAARKQELE---EIL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   604 QNVSVQLEGLERDKQQLGQENlelRKMVEamrftsakmaQIETENRQLErEKEELRRDVELLK-TLSKKSERLELSYQSV 682
Cdd:pfam01576   78 HELESRLEEEEERSQQLQNEK---KKMQQ----------HIQDLEEQLD-EEEAARQKLQLEKvTTEAKIKKLEEDILLL 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   683 SAENLQLQHSlessthKSQALQR--ELSQLEAERQALRRDLETLQLTHKQLEGAEEDRKALEQEVAQ-LEKDKKLLEKEA 759
Cdd:pfam01576  144 EDQNSKLSKE------RKLLEERisEFTSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGRQeLEKAKRKLEGES 217

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   760 RRLWQQVELKDAILDDSAAKLSAAEKESRALdkeLARCRDVGSKLKELEKDNRDLTKQvtmhtrtLTTLREDLVLEKLKS 839
Cdd:pfam01576  218 TDLQEQIAELQAQIAELRAQLAKKEEELQAA---LARLEEETAQKNNALKKIRELEAQ-------ISELQEDLESERAAR 287

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   840 QQLSSELDKLSQELEKVGLSKDLLLQEDDGHGDGKGKTESALKTTLAMKEEKIVFLEAQVEEKESLSRQLQIELQmikKE 919
Cdd:pfam01576  288 NKAEKQRRDLGEELEALKTELEDTLDTTAAQQELRSKREQEVTELKKALEEETRSHEAQLQEMRQKHTQALEELT---EQ 364

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   920 HEQLRQTQEGGDKAQNALKRPPGKV-----TSHQEKEAWEPSHKEATMELLRVKDRAIELERSNA-------ALQAERQL 987
Cdd:pfam01576  365 LEQAKRNKANLEKAKQALESENAELqaelrTLQQAKQDSEHKRKKLEGQLQELQARLSESERQRAelaeklsKLQSELES 444

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   988 LKEQLQHLETQNVSFSSQILTLQKQ----SAFLQEHTT---TLQTQTAKLQVENSTLSSQ-------NAALSAQYTVLQS 1053
Cdd:pfam01576  445 VSSLLNEAEGKNIKLSKDVSSLESQlqdtQELLQEETRqklNLSTRLRQLEDERNSLQEQleeeeeaKRNVERQLSTLQA 524

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1054 QQAAKEAEHEGLQQQQEQLAAVYEALLQDHKHLGTLYECQSSEYEALIRQHSCLKTLHRNLELEHKELGERHGDLQQRKA 1133
Cdd:pfam01576  525 QLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQK 604

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755543021  1134 ELEEL---EKVLSTER-------EALEREQKTNAIATS----ENQRLRGELDRIsflHQQLKGEYEEL 1187
Cdd:pfam01576  605 KFDQMlaeEKAISARYaeerdraEAEAREKETRALSLAraleEALEAKEELERT---NKQLRAEMEDL 669
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
453-799 1.33e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 53.77  E-value: 1.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  453 EELIREKEQLQSGMEALKA--DRARQIKDLEQEKGHLHQAVWSLRERPQvnSTKDVEKENRALHQ---AVTEAGSKLSQL 527
Cdd:COG4913   613 AALEAELAELEEELAEAEErlEALEAELDALQERREALQRLAEYSWDEI--DVASAEREIAELEAeleRLDASSDDLAAL 690

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  528 ELEKQQLHRDLEEAKEkgeQAEALEKELHRLEKENEQLTKEVTSLKAATEKVEALEHQSQGLELENRSLRKSLDTLQN-V 606
Cdd:COG4913   691 EEQLEELEAELEELEE---ELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEERFAAALGDAVEReL 767

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  607 SVQLEGlERDKQQLGQENLElRKMVEAMRftsakmaqieTENRQLEREKEELRRDVELLKTLSKKSERLElsyqsvsAEN 686
Cdd:COG4913   768 RENLEE-RIDALRARLNRAE-EELERAMR----------AFNREWPAETADLDADLESLPEYLALLDRLE-------EDG 828

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  687 L-----QLQHSLESSTHksQALQRELSQLEAERQALRRDLETLQLTHKQLEGAEEDRkaleqevAQLEKDKKLLEkEARR 761
Cdd:COG4913   829 LpeyeeRFKELLNENSI--EFVADLLSKLRRAIREIKERIDPLNDSLKRIPFGPGRY-------LRLEARPRPDP-EVRE 898

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 755543021  762 LWQqvELKDAILDDSAAKLSAAEKESRALDKELARCRD 799
Cdd:COG4913   899 FRQ--ELRAVTSGASLFDEELSEARFAALKRLIERLRS 934
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
169-580 1.43e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 53.23  E-value: 1.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  169 DKQHLAVELADTKARLRRVRQELEEKTEQLADTRHEVDQLVLELQKAKQDNIQLAADARSARAYRDE--LDSLREKANRV 246
Cdd:COG4717   122 EKLLQLLPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLatEEELQDLAEEL 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  247 ERLEMDLVRCKEKLHDVdfyKARMEELREDniilietkamlEEQLTASRARSDKVHELEKENLQLK--SKLHDLELDRDA 324
Cdd:COG4717   202 EELQQRLAELEEELEEA---QEELEELEEE-----------LEQLENELEAAALEERLKEARLLLLiaAALLALLGLGGS 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  325 DKKQIEKLLEEYMVLemaqkqsmkeSAHLGWELEQLSKNADLSDASRKsfvfELNECASSRILklekENQSLQSTIQGLR 404
Cdd:COG4717   268 LLSLILTIAGVLFLV----------LGLLALLFLLLAREKASLGKEAE----ELQALPALEEL----EEEELEELLAALG 329

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  405 DTSLALEESSLKYGELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSgmealKADRARQIKDLEQE- 483
Cdd:COG4717   330 LPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALLAEAGVEDEEELRA-----ALEQAEEYQELKEEl 404

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  484 ---KGHLHQAVWSLRERPQVNSTKDVEKENRALHQAVTEAGSKLSQLELEKQQLHRDLEEAkEKGEQAEALEKELHRLEK 560
Cdd:COG4717   405 eelEEQLEELLGELEELLEALDEEELEEELEELEEELEELEEELEELREELAELEAELEQL-EEDGELAELLQELEELKA 483

                         410       420
                  ....*....|....*....|
gi 755543021  561 ENEQLTKEVTSLKAATEKVE 580
Cdd:COG4717   484 ELRELAEEWAALKLALELLE 503
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
236-681 1.53e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 53.23  E-value: 1.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  236 LDSLREKANRVERLEMDLVRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLtasrarsdKVHELEKENLQLKSKL 315
Cdd:COG4717    70 LKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLL--------QLLPLYQELEALEAEL 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  316 HDLEldrdadkKQIEKLLEEYMVLEMAQKQsmkeSAHLGWELEQLSknadlsdasrksfvfelNECASSRILKLEKENQS 395
Cdd:COG4717   142 AELP-------ERLEELEERLEELRELEEE----LEELEAELAELQ-----------------EELEELLEQLSLATEEE 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  396 LQSTIQGLRDTSLALEESSLKYGELEKENQQLSKKIEKLQTQLEREKQSNQDLETLS----------------------- 452
Cdd:COG4717   194 LQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLllliaaallallglggsllslil 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  453 ---------------EELIREKEQLQSGMEALKADRARQIKDLEQEKGHLHQAVWSLRERPQVNSTKDVEKENRALHQAV 517
Cdd:COG4717   274 tiagvlflvlgllalLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELL 353

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  518 TEAGSKLSQLELEKQQLHR----------DLEEAKEKGEQAEALEKELHRLEKENEQLTKEVTSLKAATEKV--EALEHQ 585
Cdd:COG4717   354 REAEELEEELQLEELEQEIaallaeagveDEEELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEALdeEELEEE 433

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  586 SQGLELENRSLRKSLDTLQnvsvqleglerdkQQLGQENLELRKMVEAMRFtSAKMAQIETENRQLEREKEELRRDVELL 665
Cdd:COG4717   434 LEELEEELEELEEELEELR-------------EELAELEAELEQLEEDGEL-AELLQELEELKAELRELAEEWAALKLAL 499

                         490
                  ....*....|....*.
gi 755543021  666 KTLSKKSERLELSYQS 681
Cdd:COG4717   500 ELLEEAREEYREERLP 515
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
 395-853 1.72e-06

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 53.27  E-value: 1.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  395 SLQSTIQGLRDTSLALEESslkYGELEKENQQLSKKIEKLQTQLErekQSNQDLEtLSEELIREKEQLQSGMEALKADRA 474
Cdd:PRK10246  416 AQHAEQRPLRQRLVALHGQ---IVPQQKRLAQLQVAIQNVTQEQT---QRNAALN-EMRQRYKEKTQQLADVKTICEQEA 488

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  475 RqIKDLEQEKGHL-------------HQAVWSLRE-RPQVNSTK--DVEKENRALHqavTEAGSKLSQLELEKQQLHRDL 538
Cdd:PRK10246  489 R-IKDLEAQRAQLqagqpcplcgstsHPAVEAYQAlEPGVNQSRldALEKEVKKLG---EEGAALRGQLDALTKQLQRDE 564

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  539 EEAKekgeqaealekelhRLEKENEQLTKEVTSLKAAtekvealehqsqglelenrsLRKSLDTLQNVSVQLEGLERDKQ 618
Cdd:PRK10246  565 SEAQ--------------SLRQEEQALTQQWQAVCAS--------------------LNITLQPQDDIQPWLDAQEEHER 610

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  619 QLGQenLELRKMVEAMrfTSAKMAQIETENRQLEREKEELRRDVELLkTLSKKSERLELSYQSVSAENLQLQhslessth 698
Cdd:PRK10246  611 QLRL--LSQRHELQGQ--IAAHNQQIIQYQQQIEQRQQQLLTALAGY-ALTLPQEDEEASWLATRQQEAQSW-------- 677

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  699 ksQALQRELSQLEAERQALRRDLETLQLTHkqlEGAEEDRKALEQEVAQLEKDKKLLEKEARRLWQQVELKDAILDDSAA 778
Cdd:PRK10246  678 --QQRQNELTALQNRIQQLTPLLETLPQSD---DLPHSEETVALDNWRQVHEQCLSLHSQLQTLQQQDVLEAQRLQKAQA 752

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  779 KLSAAEKESRALDKE--LARCRDVGSkLKELEKDNRDLTKQ-------VTMHTRTLT---TLREDLVLEKLKSQQLSSEL 846
Cdd:PRK10246  753 QFDTALQASVFDDQQafLAALLDEET-LTQLEQLKQNLENQrqqaqtlVTQTAQALAqhqQHRPDGLDLTVTVEQIQQEL 831


                  ....*..
gi 755543021  847 DKLSQEL 853
Cdd:PRK10246  832 AQLAQQL 838
RecN COG0497
DNA repair ATPase RecN [Replication, recombination and repair];
532-795 1.73e-06

DNA repair ATPase RecN [Replication, recombination and repair];


Pssm-ID: 440263 [Multi-domain]  Cd Length: 555  Bit Score: 52.77  E-value: 1.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  532 QQLHRDLEEAKEKGEQAEA----LEKELHRLEK------ENEQLTKEVTSLKAATEKVEALEHQSQGLELENRSLrksLD 601
Cdd:COG0497   168 RALKKELEELRADEAERAReldlLRFQLEELEAaalqpgEEEELEEERRRLSNAEKLREALQEALEALSGGEGGA---LD 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  602 TLQNVSVQLEGLERDKQQLGqenlELRKMVEAmrftsakmAQIETE--NRQLEREKEELRRDVELLktlskksERLElsy 679
Cdd:COG0497   245 LLGQALRALERLAEYDPSLA----ELAERLES--------ALIELEeaASELRRYLDSLEFDPERL-------EEVE--- 302

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  680 qsvsaENLQLQHSLessthkSQALQRELSQLEAERQALRRDLEtlqlthkQLEGAEEDRKALEQEVAQLEKDkklLEKEA 759
Cdd:COG0497   303 -----ERLALLRRL------ARKYGVTVEELLAYAEELRAELA-------ELENSDERLEELEAELAEAEAE---LLEAA 361

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 755543021  760 RRLwqqvelkdailddSAAKLSAAEKESRALDKELA 795
Cdd:COG0497   362 EKL-------------SAARKKAAKKLEKAVTAELA 384
mukB PRK04863
chromosome partition protein MukB;
419-764 1.83e-06

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 53.42  E-value: 1.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  419 ELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSeelirekEQLQSGMEALkadraRQIKDLEQEKGHLHQAVWSLRERP 498
Cdd:PRK04863  301 QLAAEQYRLVEMARELAELNEAESDLEQDYQAAS-------DHLNLVQTAL-----RQQEKIERYQADLEELEERLEEQN 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  499 QVNSTKDVEK-ENRA-LHQAVTEAGSKLSQLELEKQQLhrDLEEAKekgeqAEALEKELHRLEKENEQLTKEVTSLKAAT 576
Cdd:PRK04863  369 EVVEEADEQQeENEArAEAAEEEVDELKSQLADYQQAL--DVQQTR-----AIQYQQAVQALERAKQLCGLPDLTADNAE 441

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  577 EKVEALEHQSQGLELENRSLRKSLDTLQNVSVQLE---------GLERDKQQLGQENLELRKMVEAMRFTSAKMAQIETE 647
Cdd:PRK04863  442 DWLEEFQAKEQEATEELLSLEQKLSVAQAAHSQFEqayqlvrkiAGEVSRSEAWDVARELLRRLREQRHLAEQLQQLRMR 521

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  648 NRQLEREKEELRRDVELLKTLSKKSER-------LELSYQSVSAENLQLQHSLESSTHKSQALQRELSQLEAERQALRR- 719
Cdd:PRK04863  522 LSELEQRLRQQQRAERLLAEFCKRLGKnlddedeLEQLQEELEARLESLSESVSEARERRMALRQQLEQLQARIQRLAAr 601

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755543021  720 --------------------DLETLQLTHKQLEGAEEDRKALEQEVAQLEKDKKLLEKEARRLWQ 764
Cdd:PRK04863  602 apawlaaqdalarlreqsgeEFEDSQDVTEYMQQLLERERELTVERDELAARKQALDEEIERLSQ 666
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 283-939 1.85e-06

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 52.90  E-value: 1.85e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   283 TKAMLEEQLTASRARSDKvheLEKENLQLKSKLHDLELDRDADKKQIEKLLEEYM-VLEMAQKQSmkesahlgweleqLS 361
Cdd:pfam10174  110 TPELTEENFRRLQSEHER---QAKELFLLRKTLEEMELRIETQKQTLGARDESIKkLLEMLQSKG-------------LP 173

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   362 KNADLSDASRKSfvfelnecassRILKLEKENQSLQSTIQGLRDTSLALEEsslkygELEKENQ--QLSKKIEKLQTQLE 439
Cdd:pfam10174  174 KKSGEEDWERTR-----------RIAEAEMQLGHLEVLLDQKEKENIHLRE------ELHRRNQlqPDPAKTKALQTVIE 236

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   440 REKQSNQDLETLSEELIREKEQLQSGMEALKADRARQIKDLEQEKGHLHQAVWSLRERPQVNSTKdvEKENRALHqavte 519
Cdd:pfam10174  237 MKDTKISSLERNIRDLEDEVQMLKTNGLLHTEDREEEIKQMEVYKSHSKFMKNKIDQLKQELSKK--ESELLALQ----- 309

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   520 agSKLSQLELEKQQLHRDLEEAKE----KGEQAEALEKELH----RLEKENEQLTKEVTSLKAATEK----VEALEHQSQ 587
Cdd:pfam10174  310 --TKLETLTNQNSDCKQHIEVLKEsltaKEQRAAILQTEVDalrlRLEEKESFLNKKTKQLQDLTEEkstlAGEIRDLKD 387

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   588 GLELENRS---LRKSLDTLQNV----SVQLEGLERDKQQLGQE----NLELRKMVEAM----RFTSAKMAQIETENRQLE 652
Cdd:pfam10174  388 MLDVKERKinvLQKKIENLQEQlrdkDKQLAGLKERVKSLQTDssntDTALTTLEEALsekeRIIERLKEQREREDRERL 467

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   653 REKEELRRDVELLK-TLSkkSERLELSYQSVSAENLQLQ-HSLESSTHKSQAlqrELSQLEAERQALRRDLETLQLTHKQ 730
Cdd:pfam10174  468 EELESLKKENKDLKeKVS--ALQPELTEKESSLIDLKEHaSSLASSGLKKDS---KLKSLEIAVEQKKEECSKLENQLKK 542

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   731 LEGAEEDRKALEQ---EVAQLEKDKKLLEKEARRLWQQVELKDAILDDSAAKLSAAEKESRALDKELARcrdvgsKLKEL 807
Cdd:pfam10174  543 AHNAEEAVRTNPEindRIRLLEQEVARYKEESGKAQAEVERLLGILREVENEKNDKDKKIAELESLTLR------QMKEQ 616

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   808 EKDNRDL-TKQVTMHTRTLTTLREDLVLE--------KLKSQQLSSELDKLSQELEKVGL---SKDLLLQEDDGH-GDGK 874
Cdd:pfam10174  617 NKKVANIkHGQQEMKKKGAQLLEEARRREdnladnsqQLQLEELMGALEKTRQELDATKArlsSTQQSLAEKDGHlTNLR 696

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755543021   875 GKTESALKTTLAMKEEKivfLEAQVEEKESLSRQLQIELQMIKKEHEQLRQTQEGGDKAQNALKR 939
Cdd:pfam10174  697 AERRKQLEEILEMKQEA---LLAAISEKDANIALLELSSSKKKKTQEEVMALKREKDRLVHQLKQ 758
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 601-795 1.87e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 52.52  E-value: 1.87e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  601 DTLQNVSVQLEGLERDKQQLGQEnleLRKMVEAMRFTSAKMAQIETENRQLEREKEELRRDVELLKT-LSKKSERLE--L 677
Cdd:COG3883    16 PQIQAKQKELSELQAELEAAQAE---LDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAeIEERREELGerA 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  678 SYQSVSAENLQLQHSLESSTHKSQALQRelsqLEAERQALRRDLETLQLTHKQLEGAEEDRKALEQEVAQLEKDKKLLEK 757
Cdd:COG3883    93 RALYRSGGSVSYLDVLLGSESFSDFLDR----LSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEA 168

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 755543021  758 EARRLWQQVELKDAILDDSAAKLSAAEKESRALDKELA 795
Cdd:COG3883   169 AKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELA 206
WEMBL pfam05701
Weak chloroplast movement under blue light; WEMBL consists of several plant proteins required ...
 514-853 2.26e-06

Weak chloroplast movement under blue light; WEMBL consists of several plant proteins required for the chloroplast avoidance response under high intensity blue light. This avoidance response consists in the relocation of chloroplasts on the anticlinal side of exposed cells. Acts in association with PMI2 to maintain the velocity of chloroplast photo-relocation movement via the regulation of cp-actin filaments. Thus several member-sequences are described as "myosin heavy chain-like".


Pssm-ID: 461718 [Multi-domain]  Cd Length: 562  Bit Score: 52.72  E-value: 2.26e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   514 HQAVTEAGSKLSQLELEKQQlhrdlEEAKEKGEQAEALEKELHRLEKENEQLTKEVTSLKAATEKVEALEHQSQglelen 593
Cdd:pfam05701   29 HRIQTVERRKLVELELEKVQ-----EEIPEYKKQSEAAEAAKAQVLEELESTKRLIEELKLNLERAQTEEAQAK------ 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   594 rslrksldtlqnvsvqleglerdkqqlgqENLELRKM-VEAMRFTSAKMAQIETENrQLEREKEELRRDVELLKTLSKKS 672
Cdd:pfam05701   98 -----------------------------QDSELAKLrVEEMEQGIADEASVAAKA-QLEVAKARHAAAVAELKSVKEEL 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   673 ERLELSYQSVSAENLQLQHSLESSTHKSQALQRELSQLEAERQALRRDLETLQLTHKQlegAEEDR----KALEQEVAQL 748
Cdd:pfam05701  148 ESLRKEYASLVSERDIAIKRAEEAVSASKEIEKTVEELTIELIATKESLESAHAAHLE---AEEHRigaaLAREQDKLNW 224

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   749 EKDKKLLEKEARRLWQQVELKdailDDSAAKLSAAEKESRALDKELARCrdVGSKLKELEKDNRDLTKQVTMHTRTLTTL 828
Cdd:pfam05701  225 EKELKQAEEELQRLNQQLLSA----KDLKSKLETASALLLDLKAELAAY--MESKLKEEADGEGNEKKTSTSIQAALASA 298

                          330       340       350
                   ....*....|....*....|....*....|....*....
gi 755543021   829 REDLV-----LEKLKSQ---------QLSSELDKLSQEL 853
Cdd:pfam05701  299 KKELEevkanIEKAKDEvnclrvaaaSLRSELEKEKAEL 337
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 598-767 2.38e-06

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 50.69  E-value: 2.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  598 KSLDTLQNVSVQLEGLERDKQQLGQENLELRKMVEAMRftsAKMAQIETENRQLEREKEELRRDVELLKTLSKKSErlEL 677
Cdd:COG1579     7 RALLDLQELDSELDRLEHRLKELPAELAELEDELAALE---ARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYE--EQ 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  678 SYQSVSAENLQ-LQHSLESSTHKSQALQRELSQLEAERQALRRDLETLQLTHKQLEGA-EEDRKALEQEVAQLEKDKKLL 755
Cdd:COG1579    82 LGNVRNNKEYEaLQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAElEEKKAELDEELAELEAELEEL 161

                         170
                  ....*....|..
gi 755543021  756 EKEARRLWQQVE 767
Cdd:COG1579   162 EAEREELAAKIP 173
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 307-633 2.50e-06

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 52.43  E-value: 2.50e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   307 ENLQLKSKLHDLELDRDADKKQIEKLLEEymvleMAQKQSMKESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRI 386
Cdd:pfam17380  267 ENEFLNQLLHIVQHQKAVSERQQQEKFEK-----MEQERLRQEKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAEQER 341

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   387 LKLEKENQ-------SLQSTIQGLRDTSLALEESSLKygELEKENQQLSKKIEKLQTQLE---------REKQSNQDLET 450
Cdd:pfam17380  342 MAMERERElerirqeERKRELERIRQEEIAMEISRMR--ELERLQMERQQKNERVRQELEaarkvkileEERQRKIQQQK 419

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   451 LSEELIR--EKEQLQSGMEALKADRARQIKDLEQEKGHLHQAVWSLRERPQVNSTKDVEKENRALHQAVTEagsklsqlE 528
Cdd:pfam17380  420 VEMEQIRaeQEEARQREVRRLEEERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAE--------E 491

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   529 LEKQQLHRDLEEAKEKgeqaeALEKELHR--LEKENEQltkEVTSLKAATEKVEALEHQSQGLELENR-SLRKSLDTLQN 605
Cdd:pfam17380  492 QRRKILEKELEERKQA-----MIEEERKRklLEKEMEE---RQKAIYEEERRREAEEERRKQQEMEERrRIQEQMRKATE 563

                          330       340       350
                   ....*....|....*....|....*....|
gi 755543021   606 VSVQLEGLERDKQQLGQ--ENLELRKMVEA 633
Cdd:pfam17380  564 ERSRLEAMEREREMMRQivESEKARAEYEA 593
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 424-995 2.58e-06

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 52.45  E-value: 2.58e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   424 NQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSG---MEAL-KADRARQI----------------KDLEQE 483
Cdd:pfam07111   58 SQALSQQAELISRQLQELRRLEEEVRLLRETSLQQKMRLEAQameLDALaVAEKAGQAeaeglraalagaemvrKNLEEG 137

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   484 KGHLHQAVWSLRERPQVNSTKDVEKENRALHQAVTEAGSKLSQLELEKQQLHRDLEEAKEkgeQAEALEKELHRLEKENE 563
Cdd:pfam07111  138 SQRELEEIQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLNSLETKRAGEAKQLAEAQK---EAELLRKQLSKTQEELE 214

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   564 QLTKEVTSLKAATEKVEALEHQSQGLELENRSLrksLDTLQNvsvqlegLERDKQQLgQENLELRKmVEAMRFTSAKMAQ 643
Cdd:pfam07111  215 AQVTLVESLRKYVGEQVPPEVHSQTWELERQEL---LDTMQH-------LQEDRADL-QATVELLQ-VRVQSLTHMLALQ 282

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   644 IETENRQLER----EKEELRRDVELLKTLSKKSERLELSYQSVSAEN-----------LQLQHSLESSTHKSQALQRELS 708
Cdd:pfam07111  283 EEELTRKIQPsdslEPEFPKKCRSLLNRWREKVFALMVQLKAQDLEHrdsvkqlrgqvAELQEQVTSQSQEQAILQRALQ 362

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   709 QLEAERQALRRDLETLQLthkQLEGAEEDRKALEQEVAQLEKDKKLLEKEARRLWQQVELKDAILDDSAAKL-SAAEKES 787
Cdd:pfam07111  363 DKAAEVEVERMSAKGLQM---ELSRAQEARRRQQQQTASAEEQLKFVVNAMSSTQIWLETTMTRVEQAVARIpSLSNRLS 439

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   788 RALDK------------ELARCR---------------DVGSKLKELEKDNRDLTKQVTMHTRTLTT----LREDLVLEK 836
Cdd:pfam07111  440 YAVRKvhtikglmarkvALAQLRqescpppppappvdaDLSLELEQLREERNRLDAELQLSAHLIQQevgrAREQGEAER 519

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   837 LK----SQQLSSELDKLSQELEKVGLSKDLLLQEDdghgdgKGKTESALKTTLAMKEEKIVFLEAQVEEKESLSRQLQIE 912
Cdd:pfam07111  520 QQlsevAQQLEQELQRAQESLASVGQQLEVARQGQ------QESTEEAASLRQELTQQQEIYGQALQEKVAEVETRLREQ 593

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   913 LQMIKKEHEQLRQTQEggdKAQNALKRPPGKVTSHQEK--EAWEPSHKEATMELLRVKDRAIELERSN----AALQAERQ 986
Cdd:pfam07111  594 LSDTKRRLNEARREQA---KAVVSLRQIQHRATQEKERnqELRRLQDEARKEEGQRLARRVQELERDKnlmlATLQQEGL 670


                   ....*....
gi 755543021   987 LLKEQLQHL 995
Cdd:pfam07111  671 LSRYKQQRL 679
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 267-476 2.59e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 52.07  E-value: 2.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  267 KARMEELREDNIILIETKAMLEEQLTASRAR----SDKVHELEKENLQLKSKLHDLELDRDADKKQIEKLLEEYM-VLEM 341
Cdd:COG4942    33 QQEIAELEKELAALKKEEKALLKQLAALERRiaalARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAeLLRA 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  342 AQKQSMKEsahlgwELEQLSKNADLSDASRKSFVFE-LNECASSRILKLEKENQSLQSTIQGLRDTSLALEEsslKYGEL 420
Cdd:COG4942   113 LYRLGRQP------PLALLLSPEDFLDAVRRLQYLKyLAPARREQAEELRADLAELAALRAELEAERAELEA---LLAEL 183

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 755543021  421 EKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEALKADRARQ 476
Cdd:COG4942   184 EEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAA 239
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 694-1305 3.70e-06

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 52.03  E-value: 3.70e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   694 ESSTHKSQALQRELSQLEAERQALRRDLETLQLTHKQLEGA-EEDRKALEQEVAQLEKDKKLLEKEARRLWQQV-ELKDA 771
Cdd:pfam05483   67 DSDFENSEGLSRLYSKLYKEAEKIKKWKVSIEAELKQKENKlQENRKIIEAQRKAIQELQFENEKVSLKLEEEIqENKDL 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   772 ILDDSAAK-LSAAEKESraldkelarCRDVGSKLKELEKDnRDLTKQVTMHTRTlTTLREDLVLEKLKSQQLSSELD--- 847
Cdd:pfam05483  147 IKENNATRhLCNLLKET---------CARSAEKTKKYEYE-REETRQVYMDLNN-NIEKMILAFEELRVQAENARLEmhf 215

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   848 KLSQELEKVglskDLLLQEDDGHGDGKGKTESALKTTLAMKEEKIVFLEAQVEEKESLSRQLQielQMIKKEHEQLRQTQ 927
Cdd:pfam05483  216 KLKEDHEKI----QHLEEEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLE---EKTKLQDENLKELI 288

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   928 EGGDKAQNALKRPPGKVT-SHQEKEAWEPSHKEATMELLRV-KDRAIELERSNAALQAE--------------RQLLKEQ 991
Cdd:pfam05483  289 EKKDHLTKELEDIKMSLQrSMSTQKALEEDLQIATKTICQLtEEKEAQMEELNKAKAAHsfvvtefeattcslEELLRTE 368

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   992 LQHLETQNVSFSSQILTLQKQSAFLQEHTTTLQTQTAKLQVENSTLSSQNAALSaqytvlQSQQAAKEAEHegLQQQQEQ 1071
Cdd:pfam05483  369 QQRLEKNEDQLKIITMELQKKSSELEEMTKFKNNKEVELEELKKILAEDEKLLD------EKKQFEKIAEE--LKGKEQE 440

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1072 LAAVYEALLQDHKHLGTLYECQSSEYEALIRQHSCLKTlhrnlELEHKELGERHGDLQQRKAELEELEKVLSTEREALER 1151
Cdd:pfam05483  441 LIFLLQAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKT-----ELEKEKLKNIELTAHCDKLLLENKELTQEASDMTLEL 515

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1152 EQKTNAIATSENQRLRgELDRISFLHQQLKGEYEELHAHTKELKTSLNNSQLELsrwqvrfDELKEQHQSMDISLTKMDN 1231
Cdd:pfam05483  516 KKHQEDIINCKKQEER-MLKQIENLEEKEMNLRDELESVREEFIQKGDEVKCKL-------DKSEENARSIEYEVLKKEK 587

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755543021  1232 HCELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMESKEQYHEEQKQyIDKLN-ALRRHKEKLEEkIMDQYK 1305
Cdd:pfam05483  588 QMKILENKCNNLKKQIENKNKNIEELHQENKALKKKGSAENKQLNAYEIK-VNKLElELASAKQKFEE-IIDNYQ 660
mukB PRK04863
chromosome partition protein MukB;
432-761 3.74e-06

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 52.27  E-value: 3.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  432 EKLQTQLEREKQSnqdLETLSEELIREKEQLQSGMEALK------------ADRARQIKDLEQEKGHLHQAVwslrerpq 499
Cdd:PRK04863  785 EKRIEQLRAEREE---LAERYATLSFDVQKLQRLHQAFSrfigshlavafeADPEAELRQLNRRRVELERAL-------- 853

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  500 vnstKDVEKENRALHQAVTEAGSKLSQLE--------LEKQQLHRDLEEAKEKGEQAEALEKELHRLEKENEQLTKEVTS 571
Cdd:PRK04863  854 ----ADHESQEQQQRSQLEQAKEGLSALNrllprlnlLADETLADRVEEIREQLDEAEEAKRFVQQHGNALAQLEPIVSV 929

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  572 LKAATEKVEALEHQSQGLELENRSLRKSLDTLQNV-----------SVQLEGLERD-----KQQLGQENLELRKMVEAMR 635
Cdd:PRK04863  930 LQSDPEQFEQLKQDYQQAQQTQRDAKQQAFALTEVvqrrahfsyedAAEMLAKNSDlneklRQRLEQAEQERTRAREQLR 1009

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  636 FTSAKMAQietENRQLEREKEELRRDVELLKTLSKKSERLELSYQSVSAENL-----QLQHSLESSTHKSQALQRELSQL 710
Cdd:PRK04863 1010 QAQAQLAQ---YNQVLASLKSSYDAKRQMLQELKQELQDLGVPADSGAEERArarrdELHARLSANRSRRNQLEKQLTFC 1086

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 755543021  711 EAERQALRRDLETLQLTHKQLEGAEEDRKALEQEVAQLEKDKKLLEKEARR 761
Cdd:PRK04863 1087 EAEMDNLTKKLRKLERDYHEMREQVVNAKAGWCAVLRLVKDNGVERRLHRR 1137
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 520-747 4.44e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 51.37  E-value: 4.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  520 AGSKLSQLELEKQQLHRDLEEAKEK----GEQAEALEKELHRLEKENEQLTKEVTSLKAATEKVEA-LEHQSQGLELENR 594
Cdd:COG3883    14 ADPQIQAKQKELSELQAELEAAQAEldalQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAeIEERREELGERAR 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  595 SLRKSLDTLQNVSVQLEGlerdkQQLGQ--ENLELRKMVeaMRFTSAKMAQIETENRQLEREKEELRRDVELLKTLSKKS 672
Cdd:COG3883    94 ALYRSGGSVSYLDVLLGS-----ESFSDflDRLSALSKI--ADADADLLEELKADKAELEAKKAELEAKLAELEALKAEL 166

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755543021  673 ERLELSYQSVSAENLQLQHSLESsthKSQALQRELSQLEAERQALRRDLETLQLTHKQLEGAEEDRKALEQEVAQ 747
Cdd:COG3883   167 EAAKAELEAQQAEQEALLAQLSA---EEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 238
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 186-1026 4.51e-06

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 51.88  E-value: 4.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  186 RVRQELEEKTEQLADTRHE----VDQLVLELQKAKQDNIQLAADARSARAYRDELDSLREKANRVerleMDLVRCKEKlh 261
Cdd:COG3096   275 RHANERRELSERALELRRElfgaRRQLAEEQYRLVEMARELEELSARESDLEQDYQAASDHLNLV----QTALRQQEK-- 348

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  262 dVDFYKARMEELREDNIILIETKAMLEEQLTASRARsdkVHELEKENLQLKSKLHDLE-------------------LDR 322
Cdd:COG3096   349 -IERYQEDLEELTERLEEQEEVVEEAAEQLAEAEAR---LEAAEEEVDSLKSQLADYQqaldvqqtraiqyqqavqaLEK 424

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  323 --------DADKKQIEKLLEEYMVLEMAQKQSMKESAHlgweleQLSknadLSDASRKSF--VFELNECASSRILKLEKE 392
Cdd:COG3096   425 aralcglpDLTPENAEDYLAAFRAKEQQATEEVLELEQ------KLS----VADAARRQFekAYELVCKIAGEVERSQAW 494

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  393 NQSLQSTIQGLRDTSLALEESSL--KYGELEK---ENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGME 467
Cdd:COG3096   495 QTARELLRRYRSQQALAQRLQQLraQLAELEQrlrQQQNAERLLEEFCQRIGQQLDAAEELEELLAELEAQLEELEEQAA 574

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  468 ALKADRARqikdLEQEKGHLHQAVWSLRERP------QVNSTKDVEKENRALH--QAVTEAGSKLSQLELEKQQLHRDLE 539
Cdd:COG3096   575 EAVEQRSE----LRQQLEQLRARIKELAARApawlaaQDALERLREQSGEALAdsQEVTAAMQQLLEREREATVERDELA 650

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  540 EAKekgeqaEALEKELHRL---------------EKENEQLTKEV---TSLKAATEkVEALEHQS-QGLELENRSL-RKS 599
Cdd:COG3096   651 ARK------QALESQIERLsqpggaedprllalaERLGGVLLSEIyddVTLEDAPY-FSALYGPArHAIVVPDLSAvKEQ 723

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  600 LDTLQNVSVQLEGLERDKQQ-----LGQENLELRKMVE----AMRFT----------SAKMAQIETenrqLEREKEELrr 660
Cdd:COG3096   724 LAGLEDCPEDLYLIEGDPDSfddsvFDAEELEDAVVVKlsdrQWRYSrfpevplfgrAAREKRLEE----LRAERDEL-- 797

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  661 dVELLKTLSKKSERLELSYQSVSAenlqlqhslESSTHKSQALQrelSQLEAERQALRRDLETLQlthKQLEGAEEDRKA 740
Cdd:COG3096   798 -AEQYAKASFDVQKLQRLHQAFSQ---------FVGGHLAVAFA---PDPEAELAALRQRRSELE---RELAQHRAQEQQ 861

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  741 LEQEVAQLEKDKKLLekeaRRLWQQVELKDAilDDSAAKLSAAEKESRALDKELARCRDVGSKLKELEkdnrdltkqvtm 820
Cdd:COG3096   862 LRQQLDQLKEQLQLL----NKLLPQANLLAD--ETLADRLEELREELDAAQEAQAFIQQHGKALAQLE------------ 923

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  821 htRTLTTLRED-LVLEKLKS--QQLSSELDKLSQELEkvGLSKDLLLQEDDGHGDgkgkTESALKTTLAMKEEkivfLEA 897
Cdd:COG3096   924 --PLVAVLQSDpEQFEQLQAdyLQAKEQQRRLKQQIF--ALSEVVQRRPHFSYED----AVGLLGENSDLNEK----LRA 991

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  898 QVEEKESLSRQLQIELQMIKKEHEQLRQTQEGGDKAQNAlkrppgKVTSHQEKEawepshKEatMELLRVKDRAIELERS 977
Cdd:COG3096   992 RLEQAEEARREAREQLRQAQAQYSQYNQVLASLKSSRDA------KQQTLQELE------QE--LEELGVQADAEAEERA 1057

                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 755543021  978 naalQAERQLLKEQLQH-------LETQNVSFSSQILTLQKQSAFLQEHTTTLQTQ 1026
Cdd:COG3096  1058 ----RIRRDELHEELSQnrsrrsqLEKQLTRCEAEMDSLQKRLRKAERDYKQEREQ 1109
PTZ00121 PTZ00121
MAEBL; Provisional
 176-546 4.76e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 52.07  E-value: 4.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  176 ELADTKARLRRVRQELEEKTEQL--ADTRHEVDQLVLELQKAKQDNIQLAADARSARAYR--DELDSLREK-----ANRV 246
Cdd:PTZ00121 1493 EEAKKKADEAKKAAEAKKKADEAkkAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKkaEELKKAEEKkkaeeAKKA 1572

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  247 ERLEMDLVRCKEKLHDVDfyKARMEELREdniILIETKAMLEEQLTASRARSDKVHELEKENlQLKSKLHDLELDRDADK 326
Cdd:PTZ00121 1573 EEDKNMALRKAEEAKKAE--EARIEEVMK---LYEEEKKMKAEEAKKAEEAKIKAEELKKAE-EEKKKVEQLKKKEAEEK 1646

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  327 KQIEKLLEEYMVLEMAQKQSMKESAHLGWELEQLSKNADlsDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDt 406
Cdd:PTZ00121 1647 KKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEE--DEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKK- 1723

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  407 slALEESSLKYGELEKENQQLSKKIEKLQTQLEREK---QSNQDLETLSEELIRE-----KEQLQSGMEALKADRARQIK 478
Cdd:PTZ00121 1724 --AEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKkiaHLKKEEEKKAEEIRKEkeaviEEELDEEDEKRRMEVDKKIK 1801

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  479 DLE------QEKGHLHQAVWSLRERPQVNSTK--------------DVEKENRALHQAVTEAGSKLSQLELEKQQLHRDL 538
Cdd:PTZ00121 1802 DIFdnfaniIEGGKEGNLVINDSKEMEDSAIKevadsknmqleeadAFEKHKFNKNNENGEDGNKEADFNKEKDLKEDDE 1881


                  ....*...
gi 755543021  539 EEAKEKGE 546
Cdd:PTZ00121 1882 EEIEEADE 1889
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
715-925 5.12e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 51.84  E-value: 5.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  715 QALRRDLETLQLTHKQLEGAEEDRKALEQEVAQLEkdkkllekEARRLWQQVELKDAILddSAAKLSAAEKESRALDKEL 794
Cdd:COG4913   228 DALVEHFDDLERAHEALEDAREQIELLEPIRELAE--------RYAAARERLAELEYLR--AALRLWFAQRRLELLEAEL 297

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  795 ARCRDvgsKLKELEKDNRDLTKQVTMHTRTLTTLREDL------VLEKLKSQ--QLSSELDKLSQELEKV-GLSKDLLLQ 865
Cdd:COG4913   298 EELRA---ELARLEAELERLEARLDALREELDELEAQIrgnggdRLEQLEREieRLERELEERERRRARLeALLAALGLP 374

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  866 EDDGHGDGKgKTESALKTTLAMKEEKIVFLEAQVEEKESLSRQLQIELQMIKKEHEQLRQ 925
Cdd:COG4913   375 LPASAEEFA-ALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLER 433
Tektin pfam03148
Tektin family; Tektins are cytoskeletal proteins. They have been demonstrated in such cellular ...
 446-725 5.26e-06

Tektin family; Tektins are cytoskeletal proteins. They have been demonstrated in such cellular sites as centrioles, basal bodies, and along ciliary and flagellar doublet microtubules. Tektins form unique protofilaments, organized as longitudinal polymers of tektin heterodimers with axial periodicity matching tubulin. Tektin polypeptides consist of several alpha-helical regions that are predicted to form coiled coils. Indeed, tektins share considerable structural similarities with intermediate filament proteins. Possible functional roles for tektins are: stabilization of tubulin protofilaments; attachment of A and B-tubules in ciliary/flagellar microtubule doublets and C-tubules in centrioles; binding of axonemal components.


Pssm-ID: 460827 [Multi-domain]  Cd Length: 383  Bit Score: 51.01  E-value: 5.26e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   446 QDLETLSEELIREKEQLQSGMEALKADRARQIKDLEQEKGHLHQAVWSL--RE-RPQVNSTKD-VEKE-----------N 510
Cdd:pfam03148   53 QDITFWKSELEKELEELDEEIELLLEEKRRLEKALEALEEPLHIAQECLtlREkRQGIDLVHDeVEKEllkeveliegiQ 132

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   511 RALHQAVTEAGSKLSQLELEKQQLHRDLEEAKekgeqaEALEkelhrLEKENEQLTKEVT--SLKAATEKVEAL------ 582
Cdd:pfam03148  133 ELLQRTLEQAWEQLRLLRAARHKLEKDLSDKK------EALE-----IDEKCLSLNNTSPniSYKPGPTRIPPNsstpee 201

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   583 -EHQSQGL------ELEN-RSLRKSLD-TLQNVSVQLeglerdKQQLGQENLELRKMVEAMRftSAKmAQIETENRQLER 653
Cdd:pfam03148  202 wEKFTQDNieraekERAAsAQLRELIDsILEQTANDL------RAQADAVNFALRKRIEETE--DAK-NKLEWQLKKTLQ 272

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   654 EKEELRRDVELL-KTLSKKSE-------RLELSYQSVSAENL--QLQHSLESSTHK----SQALQRELSQLEAERQALRR 719
Cdd:pfam03148  273 EIAELEKNIEALeKAIRDKEAplklaqtRLENRTYRPNVELCrdEAQYGLVDEVKEleetIEALKQKLAEAEASLQALER 352


                   ....*.
gi 755543021   720 DLETLQ 725
Cdd:pfam03148  353 TRLRLE 358
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1329-1804 6.44e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 51.33  E-value: 6.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1329 PKKEGSRERLKSTTDSPPWQLEPSDPASPSPSqalRSQTENPDNPPSGPNCVEERDthnGPVGKGPGDLKPKRgsPRGGS 1408
Cdd:PHA03307   72 PPGPGTEAPANESRSTPTWSLSTLAPASPARE---GSPTPPGPSSPDPPPPTPPPA---SPPPSPAPDLSEML--RPVGS 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1409 VDRTDTSTDPAVKSWPSEPGSRTfSTSATTAALSSSTPIPKHLGRTKGcnsddnlCEPSSEPDGPYHRQQASRPNSless 1488
Cdd:PHA03307  144 PGPPPAASPPAAGASPAAVASDA-ASSRQAALPLSSPEETARAPSSPP-------AEPPPSTPPAAASPRPPRRSS---- 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1489 rnassnssPLSLKGSSDhlhsrcesfSSADLIPSRDPATLSRDGNTS----GRGLLGRHEYPPPRNGPVSQETIQKKGAA 1564
Cdd:PHA03307  212 --------PISASASSP---------APAPGRSAADDAGASSSDSSSsessGCGWGPENECPLPRPAPITLPTRIWEASG 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1565 STHTGVRPHSASPSSEmvtleefleesnrggspthdtpscrddllsdyfrkahdPPALGGQPGPPARKDGAKMPTSfvap 1644
Cdd:PHA03307  275 WNGPSSRPGPASSSSS--------------------------------------PRERSPSPSPSSPGSGPAPSSP---- 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1645 tikmsintsegqqlkpghyvkpnlRPSEAEAlagmPSRQVQPPQSLSLGRPRQTtmtqnchMPVSRSASLSRAFSLASAD 1724
Cdd:PHA03307  313 ------------------------RASSSSS----SSRESSSSSTSSSSESSRG-------AAVSPGPSPSRSPSPSRPP 357

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1725 LLRASGPEACRPESPQKPGGHEAAGARETS--THSLQGSHILARERTPivgkadsPSPGQGTRGRPLDTRRFSLAPPKEE 1802
Cdd:PHA03307  358 PPADPSSPRKRPRPSRAPSSPAASAGRPTRrrARAAVAGRARRRDATG-------RFPAGRPRPSPLDAGAASGAFYARY 430


                  ..
gi 755543021 1803 RL 1804
Cdd:PHA03307  431 PL 432
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 698-1299 7.24e-06

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 51.38  E-value: 7.24e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   698 HKSQALQR------ELSQLEAERQALRRDLETLQLTHKQLEGAEEDRKALEQEVAQLEKDKKLLEKEARRLWQQVeLKDA 771
Cdd:pfam12128  228 RDIQAIAGimkirpEFTKLQQEFNTLESAELRLSHLHFGYKSDETLIASRQEERQETSAELNQLLRTLDDQWKEK-RDEL 306

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   772 ILDDSAAK--LSAAEKESRALDKELARCRDVGSKLKELEKDNRDLTK----QVTMHTRTLTTLREDL-----VLEKLKSQ 840
Cdd:pfam12128  307 NGELSAADaaVAKDRSELEALEDQHGAFLDADIETAAADQEQLPSWQseleNLEERLKALTGKHQDVtakynRRRSKIKE 386

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   841 QLSSELDKLSQELEKVGLSKDLLLQEDDGH------------------------------GDGKGKTESALKT--TLAMK 888
Cdd:pfam12128  387 QNNRDIAGIKDKLAKIREARDRQLAVAEDDlqaleselreqleagklefneeeyrlksrlGELKLRLNQATATpeLLLQL 466

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   889 EEKIVFLEAQVEEKESLSRQ---LQIELQMIKK-----------EHEQLRQTQEGGDKAQNALKRPPGKVTSHQEKEA-- 952
Cdd:pfam12128  467 ENFDERIERAREEQEAANAEverLQSELRQARKrrdqasealrqASRRLEERQSALDELELQLFPQAGTLLHFLRKEApd 546

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   953 WEPSH-KEATMELLRVKD-----------------------------------RAIELERSNA--ALQAERQLLKEQLQH 994
Cdd:pfam12128  547 WEQSIgKVISPELLHRTDldpevwdgsvggelnlygvkldlkridvpewaaseEELRERLDKAeeALQSAREKQAAAEEQ 626

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   995 LETQNVSFSSQILTLQKQSAFLQEHTTTL-----QTQTAKLQVENSTLSSQNAA------LSAQYTVL-QSQQAAKEAEH 1062
Cdd:pfam12128  627 LVQANGELEKASREETFARTALKNARLDLrrlfdEKQSEKDKKNKALAERKDSAnerlnsLEAQLKQLdKKHQAWLEEQK 706

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1063 EGLQQQQEQLAAVYEALLQDHK-HLGTLYECQSSEYEALIRQHSCLKTLHRNlELEHKEL-GERHGDLQQRKAELEE-LE 1139
Cdd:pfam12128  707 EQKREARTEKQAYWQVVEGALDaQLALLKAAIAARRSGAKAELKALETWYKR-DLASLGVdPDVIAKLKREIRTLERkIE 785

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1140 KVLSTEREALEREQKTNAIATSENQRLRGELDRISFLHQQLKGEYEELHAHTKelktsLNNSQLELSRwqvrfDELKEQH 1219
Cdd:pfam12128  786 RIAVRRQEVLRYFDWYQETWLQRRPRLATQLSNIERAISELQQQLARLIADTK-----LRRAKLEMER-----KASEKQQ 855

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1220 QSMDISLTKMDNHCELLSRLK--GNLEEENHHLLSQIQLLSQQnQMLLEQNMESKEQYHEEQKQYIDKL--NALRRHKEK 1295
Cdd:pfam12128  856 VRLSENLRGLRCEMSKLATLKedANSEQAQGSIGERLAQLEDL-KLKRDYLSESVKKYVEHFKNVIADHsgSGLAETWES 934


                   ....
gi 755543021  1296 LEEK 1299
Cdd:pfam12128  935 LREE 938
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 116-444 7.56e-06

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 51.22  E-value: 7.56e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   116 HLRRLIDERDECTELIVDLTQERDYLQTQQppspgkfsspdSTPSPTSSLSSEDKQHLAVELADTKARLRRVRQELEEKT 195
Cdd:TIGR02169  703 RLDELSQELSDASRKIGEIEKEIEQLEQEE-----------EKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELE 771

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   196 EQLADTRHEVDQLVLELQKAKQDNIQlaadaRSARAYRDELDSLREKANRVERLEMDLVRCKEKLHD--------VDFYK 267
Cdd:TIGR02169  772 EDLHKLEEALNDLEARLSHSRIPEIQ-----AELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKeiqelqeqRIDLK 846

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   268 ARMEELR----EDNIILIETKAMLEEQLTASRARSDKVHELEKENLQLKSKLHDLELDRDADKKQIEKLLEEYMVLEMAQ 343
Cdd:TIGR02169  847 EQIKSIEkeieNLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKL 926

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   344 KQSMKESAHLGWELEQLSknadlsdasrksfvfELNECASSrILKLEKENQSLQSTIQGLRDTSLA----LEESSLKYGE 419
Cdd:TIGR02169  927 EALEEELSEIEDPKGEDE---------------EIPEEELS-LEDVQAELQRVEEEIRALEPVNMLaiqeYEEVLKRLDE 990

                          330       340
                   ....*....|....*....|....*...
gi 755543021   420 LEKENQQL---SKKIEKLQTQLEREKQS 444
Cdd:TIGR02169  991 LKEKRAKLeeeRKAILERIEEYEKKKRE 1018
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 56-718 7.86e-06

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 51.12  E-value: 7.86e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021    56 ERKEEFIERIKQLDIETQ-AGIVAHIQEVTHNQENVFDLQWLDLPDVAPEELEALS---RNMVFHLRRLIDERDECTELI 131
Cdd:TIGR00618  163 KEKKELLMNLFPLDQYTQlALMEFAKKKSLHGKAELLTLRSQLLTLCTPCMPDTYHerkQVLEKELKHLREALQQTQQSH 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   132 VDLTQERDYLQTQQPPSPGKFSSPDSTPSPTSSLSSEDKQHLAVELADTKARL--------------RRVRQELEEKTEQ 197
Cdd:TIGR00618  243 AYLTQKREAQEEQLKKQQLLKQLRARIEELRAQEAVLEETQERINRARKAAPLaahikavtqieqqaQRIHTELQSKMRS 322

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   198 LADTRH----------EVDQLVLELQKAKQDNIQLAADARSARAYRDELDSLREKANRVERLEMDLVRCKEKL------- 260
Cdd:TIGR00618  323 RAKLLMkraahvkqqsSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHTLTQHIHTLQQQKTTLTQKLqslckel 402

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   261 -------HDVDFYKARMEELREDNIILIETKAMLEEQLTASRARSDKVHELEKENLQLKSKLH---DLELDRDADKKQIE 330
Cdd:TIGR00618  403 dilqreqATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQESAqslKEREQQLQTKEQIH 482

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   331 KLLEEYMVLEMAQKQSMKEsahlgwelEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDTSLAL 410
Cdd:TIGR00618  483 LQETRKKAVVLARLLELQE--------EPCPLCGSCIHPNPARQDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSE 554

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   411 EESSLKYGELEKENQQ----LSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEALKADRARQIKDLE----- 481
Cdd:TIGR00618  555 RKQRASLKEQMQEIQQsfsiLTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDvrlhl 634

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   482 --------QEKGHLHQAVWSL---RERPQVNSTKDVEKENRALHQAvteagsKLSQLELEKQQLHRDLEEAKEKGEQAEA 550
Cdd:TIGR00618  635 qqcsqelaLKLTALHALQLTLtqeRVREHALSIRVLPKELLASRQL------ALQKMQSEKEQLTYWKEMLAQCQTLLRE 708

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   551 LEKELHRLEKENEQLTKEVTSLKAATEKVEALEHQSQG--LELENRSLRKSLDTLQNVSVQLEGLERDKQQLGQ--ENLE 626
Cdd:TIGR00618  709 LETHIEEYDREFNEIENASSSLGSDLAAREDALNQSLKelMHQARTVLKARTEAHFNNNEEVTAALQTGAELSHlaAEIQ 788

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   627 LRKMVEAMRFTSAKMAQIETENRQLEREKEELRRDVELLKTLSKKSERLELSYQSVSAENLQLQHSLESSTHKSQALQR- 705
Cdd:TIGR00618  789 FFNRLREEDTHLLKTLEAEIGQEIPSDEDILNLQCETLVQEEEQFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQEq 868

                          730
                   ....*....|....
gi 755543021   706 -ELSQLEAERQALR 718
Cdd:TIGR00618  869 aKIIQLSDKLNGIN 882
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
538-677 8.02e-06

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 51.01  E-value: 8.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  538 LEEAKEKgEQAEALEKELHRLEKENEQLTKEVTSLKAATEKVEALEHQSQGLELENRSLRKSLDTLQnvsvqlEGLERDK 617
Cdd:COG2433   382 LEELIEK-ELPEEEPEAEREKEHEERELTEEEEEIRRLEEQVERLEAEVEELEAELEEKDERIERLE------RELSEAR 454

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  618 QQLGQENLELRKmVEAMRftsAKMAQIETENRQLEREKEELRRDVELLKTLSKKSERLEL 677
Cdd:COG2433   455 SEERREIRKDRE-ISRLD---REIERLERELEEERERIEELKRKLERLKELWKLEHSGEL 510
mukB PRK04863
chromosome partition protein MukB;
382-1187 9.14e-06

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 51.11  E-value: 9.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  382 ASSRILKLEKENQSLQSTI----QGLRDTSLALEESSLKYGELEKENQQLSKKIEKLQT---QLEREKQSNQDLETLSE- 453
Cdd:PRK04863  284 HLEEALELRRELYTSRRQLaaeqYRLVEMARELAELNEAESDLEQDYQAASDHLNLVQTalrQQEKIERYQADLEELEEr 363

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  454 ----------------ELIREKEQLQSGMEALKADRA--RQIKDLEQEK-GHLHQAVWSLRERPQVNSTKDVEKENralh 514
Cdd:PRK04863  364 leeqnevveeadeqqeENEARAEAAEEEVDELKSQLAdyQQALDVQQTRaIQYQQAVQALERAKQLCGLPDLTADN---- 439

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  515 qavteAGSKLSQLELEKQQLhrdleeakekGEQAEALEKELHRLEKENEQLTKEVTSLKAATEKVEALEHQSQGLELENR 594
Cdd:PRK04863  440 -----AEDWLEEFQAKEQEA----------TEELLSLEQKLSVAQAAHSQFEQAYQLVRKIAGEVSRSEAWDVARELLRR 504

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  595 slrksLDTLQNVSVQLEGLERDKQQLGQENLELRKMVEAMRFTSAKMAQIETENRQLEREKEELRrdvELLKTLSKKSER 674
Cdd:PRK04863  505 -----LREQRHLAEQLQQLRMRLSELEQRLRQQQRAERLLAEFCKRLGKNLDDEDELEQLQEELE---ARLESLSESVSE 576

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  675 LELSYQSVSAENLQLQ---HSLESSTHKSQALQRELSQLEA---ERQALRRDLETLQLTHkqlegAEEDRkALEQEVAQL 748
Cdd:PRK04863  577 ARERRMALRQQLEQLQariQRLAARAPAWLAAQDALARLREqsgEEFEDSQDVTEYMQQL-----LERER-ELTVERDEL 650

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  749 EKDKKLLEKEARRLWQQ--------------------VELKDAILDDSAAKLSAAEKESR-ALdkelaRCRDVGSKLKEL 807
Cdd:PRK04863  651 AARKQALDEEIERLSQPggsedprlnalaerfggvllSEIYDDVSLEDAPYFSALYGPARhAI-----VVPDLSDAAEQL 725

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  808 EkdnrdltkqvtmhtrTLTTLREDLVLEKLKSQQL-SSELDklSQELEKvglskDLLLQEDDGHGDGKGKTESALKTTLA 886
Cdd:PRK04863  726 A---------------GLEDCPEDLYLIEGDPDSFdDSVFS--VEELEK-----AVVVKIADRQWRYSRFPEVPLFGRAA 783

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  887 mKEEKIVFLEAQVEEKESLSRQLQIELQMIKKEHEQLRQTqeggdkaqnalkrppgkVTSH-QEKEAWEPshkEATMELL 965
Cdd:PRK04863  784 -REKRIEQLRAEREELAERYATLSFDVQKLQRLHQAFSRF-----------------IGSHlAVAFEADP---EAELRQL 842

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  966 RvkDRAIELERsnaalqaerqllkeQLQHLETQNVSFSSQILTLQKQSAFLQEhtttLQTQTAKLQVEnsTLSSQNAALS 1045
Cdd:PRK04863  843 N--RRRVELER--------------ALADHESQEQQQRSQLEQAKEGLSALNR----LLPRLNLLADE--TLADRVEEIR 900

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1046 AQytVLQSQQAAKE-AEHEGLQQQQEQLAAVYEALLQDHKHLGTLYECQSSEYEALIRQHSCLKTL-----HRNLELEHK 1119
Cdd:PRK04863  901 EQ--LDEAEEAKRFvQQHGNALAQLEPIVSVLQSDPEQFEQLKQDYQQAQQTQRDAKQQAFALTEVvqrraHFSYEDAAE 978

                         810       820       830       840       850       860
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755543021 1120 ELGERHGDLQQRKAELEELEKVLSTEREALEREQKTNAIATSENQRLRGELDRISFLHQQLKGEYEEL 1187
Cdd:PRK04863  979 MLAKNSDLNEKLRQRLEQAEQERTRAREQLRQAQAQLAQYNQVLASLKSSYDAKRQMLQELKQELQDL 1046
PRK11281 PRK11281
mechanosensitive channel MscK;
515-758 9.96e-06

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 50.68  E-value: 9.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  515 QAVTEAGSKLSQLELEKQQLHRDLEEAKEKGEQAEALEKELHRLEKENEQL-------TKEVTSLKAATEKVEALEHQSQ 587
Cdd:PRK11281   42 QAQLDALNKQKLLEAEDKLVQQDLEQTLALLDKIDRQKEETEQLKQQLAQApaklrqaQAELEALKDDNDEETRETLSTL 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  588 GL-ELENRsLRKSLDTLQNVSVQLegLERDKQQLGQENLELRKMVeAMRFTSAKMAQIeteNRQLEREKEELRRDVELLK 666
Cdd:PRK11281  122 SLrQLESR-LAQTLDQLQNAQNDL--AEYNSQLVSLQTQPERAQA-ALYANSQRLQQI---RNLLKGGKVGGKALRPSQR 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  667 TLskkserLELSYQSVSAENLQLQHSLESSTHKSQALQRELSQLEAERQALRRDLETLQ--LTHKQLEGAEED-RKALEQ 743
Cdd:PRK11281  195 VL------LQAEQALLNAQNDLQRKSLEGNTQLQDLLQKQRDYLTARIQRLEHQLQLLQeaINSKRLTLSEKTvQEAQSQ 268

                         250
                  ....*....|....*
gi 755543021  744 EVAQLEKDKKLLEKE 758
Cdd:PRK11281  269 DEAARIQANPLVAQE 283
HkD_Hook2 cd22227
Hook domain found in protein Hook 2 (Hook2) and similar proteins; Hook2 is a ...
 40-83 1.06e-05

Hook domain found in protein Hook 2 (Hook2) and similar proteins; Hook2 is a microtubule-binding protein that contributes to the establishment and maintenance of centrosome function. It may function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones. Hook2 is a component of the FTS/Hook/FHIP complex (FHF complex), which may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting (HOPS) complex.


Pssm-ID: 411798  Cd Length: 150  Bit Score: 47.18  E-value: 1.06e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 755543021   40 EIKKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEV 83
Cdd:cd22227   104 ELGKLLQLVLGCAISCEKKQEHIQQIMTLEESVQHVVMEAIQEL 147
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 897-1161 1.06e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 50.15  E-value: 1.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  897 AQVEEKESLSRQLQIELQMIKKEHEQLRQTQEGGDKAQNALKRppgkvtshQEKEAwepshKEATMELLRVKDRAIELER 976
Cdd:COG4942    17 AQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAA--------LERRI-----AALARRIRALEQELAALEA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  977 SNAALQAERQLLKEQLQHLETQnvsFSSQILTLQKQSaflqehtttlqtQTAKLQVENSTLSSQNAALSAQYtvLQSQQA 1056
Cdd:COG4942    84 ELAELEKEIAELRAELEAQKEE---LAELLRALYRLG------------RQPPLALLLSPEDFLDAVRRLQY--LKYLAP 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1057 AKEAEHEGLQQQQEQLAAVYEALLQDHKHLGTLYECQSSEYEALIRQHSCLKTLHRNLELEHKELGERHGDLQQRKAELE 1136
Cdd:COG4942   147 ARREQAEELRADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELE 226

                         250       260
                  ....*....|....*....|....*
gi 755543021 1137 ELEKVLSTEREALEREQKTNAIATS 1161
Cdd:COG4942   227 ALIARLEAEAAAAAERTPAAGFAAL 251
COG5022 COG5022
Myosin heavy chain [General function prediction only];
267-903 1.19e-05

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 50.46  E-value: 1.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  267 KARMEELREDNIILIETKAM--LEEQLTASRARSDKVHELEKENLQLKSKLhdLELDRDADKKQIEKLleeymvlemaqK 344
Cdd:COG5022   858 KKRFSLLKKETIYLQSAQRVelAERQLQELKIDVKSISSLKLVNLELESEI--IELKKSLSSDLIENL-----------E 924

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  345 QSMKESAHLgwelEQLSKNADLSDASRKSFVfelnecassrilkLEKENQSLQSTIQGLRDTSLaleesslkygELEKEN 424
Cdd:COG5022   925 FKTELIARL----KKLLNNIDLEEGPSIEYV-------------KLPELNKLHEVESKLKETSE----------EYEDLL 977

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  425 QQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQlqsgmealkadrARQIKDLEQEKGHLHQAVWSLRERPQ-VNST 503
Cdd:COG5022   978 KKSTILVREGNKANSELKNFKKELAELSKQYGALQES------------TKQLKELPVEVAELQSASKIISSESTeLSIL 1045

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  504 KDVEKENRALHQAVTEAGSKLSQLELEKQQLHRDLEEAKekgeQAEALEKELHRLEKENEQLTKEVTSLKAATEKVEALE 583
Cdd:COG5022  1046 KPLQKLKGLLLLENNQLQARYKALKLRRENSLLDDKQLY----QLESTENLLKTINVKDLEVTNRNLVKPANVLQFIVAQ 1121

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  584 HQSQGLELE-NRSLRKSLDTLQNVSVQLEGLERDKQQLGQEnlelrKMVEAMRFTSAKMAQIETENRQLEREKEELRRDV 662
Cdd:COG5022  1122 MIKLNLLQEiSKFLSQLVNTLEPVFQKLSVLQLELDGLFWE-----ANLEALPSPPPFAALSEKRLYQSALYDEKSKLSS 1196

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  663 ELLKTLskKSERLELSYQSVSAENLQLqHSLESSTHKSQALQRELSQLEAERQALRRDLETLQLTHKQLEGAEEDRKALE 742
Cdd:COG5022  1197 SEVNDL--KNELIALFSKIFSGWPRGD-KLKKLISEGWVPTEYSTSLKGFNNLNKKFDTPASMSNEKLLSLLNSIDNLLS 1273

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  743 QEVAQLEkdkkLLEKEARRLWQQVELKDA---ILDDSAAKLSAAEKESRALDKELARCRDVG--------------SKLK 805
Cdd:COG5022  1274 SYKLEEE----VLPATINSLLQYINVGLFnalRTKASSLRWKSATEVNYNSEELDDWCREFEisdvdeeleeliqaVKVL 1349

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  806 ELEKDNRDLTKQVTMHTRTLTTLRedlvLEKLKSQ-QLSSELDKLSQELEKvGLSKDLLLQEDDGHGDGKGKTESALKTT 884
Cdd:COG5022  1350 QLLKDDLNKLDELLDACYSLNPAE----IQNLKSRyDPADKENNLPKEILK-KIEALLIKQELQLSLEGKDETEVHLSEI 1424

                         650
                  ....*....|....*....
gi 755543021  885 LAMKEEKIvFLEAQVEEKE 903
Cdd:COG5022  1425 FSEEKSLI-SLDRNSIYKE 1442
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
 454-855 1.23e-05

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 50.07  E-value: 1.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   454 ELIREKEQLQSGMEALKadraRQIKDLEQEKGHLHQAVWSLRERpqVNSTKDVEKENralhqavTEAGSKLSQLELEKQQ 533
Cdd:pfam05622    4 EAQEEKDELAQRCHELD----QQVSLLQEEKNSLQQENKKLQER--LDQLESGDDSG-------TPGGKKYLLLQKQLEQ 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   534 LHRD---LEEAKEKGEQ-AEALEKELHRLEKENEQLTK----------EVTSLKAATEKVEALEHQSQglelenrSLRKS 599
Cdd:pfam05622   71 LQEEnfrLETARDDYRIkCEELEKEVLELQHRNEELTSlaeeaqalkdEMDILRESSDKVKKLEATVE-------TYKKK 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   600 LDTLQNVSVQLEGLERDKQQLGQENLELRkmvEAMRFTSAKMAQIETENRQLErekeELRRDvelLKTLSKKSERLELSY 679
Cdd:pfam05622  144 LEDLGDLRRQVKLLEERNAEYMQRTLQLE---EELKKANALRGQLETYKRQVQ----ELHGK---LSEESKKADKLEFEY 213

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   680 QsvsaeNLQLQHSlessthksqALQRELSQLEAERQALRRDLETL---QLTHKQLEGAEEDRKA-------LEQEVAQLE 749
Cdd:pfam05622  214 K-----KLEEKLE---------ALQKEKERLIIERDTLRETNEELrcaQLQQAELSQADALLSPssdpgdnLAAEIMPAE 279

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   750 KDKKL--LEKEARRLW-QQVELKDAILDDSAAKLSAAEKESRALDKELarcRDVGSKLKELEKDNRDLTKqvtmHTRTLT 826
Cdd:pfam05622  280 IREKLirLQHENKMLRlGQEGSYRERLTELQQLLEDANRRKNELETQN---RLANQRILELQQQVEELQK----ALQEQG 352

                          410       420
                   ....*....|....*....|....*....
gi 755543021   827 TLREDLVLEKLKSQQLSSELDKLSQELEK 855
Cdd:pfam05622  353 SKAEDSSLLKQKLEEHLEKLHEAQSELQK 381
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
842-1281 1.34e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 50.15  E-value: 1.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  842 LSSELDKLSQELEKVGLSKDLLLQEDDGHGDGKGKTESALKTTLAMKEEKIVFLEAQVEEKESLSRQLQIELQMIKKEHE 921
Cdd:COG4717    47 LLERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQ 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  922 QLRQTQEgGDKAQNALKRPPGKVTSHQEKEAwepSHKEATMELLRVKDRAIELERS-NAALQAERQLLKEQLQHLETQNV 1000
Cdd:COG4717   127 LLPLYQE-LEALEAELAELPERLEELEERLE---ELRELEEELEELEAELAELQEElEELLEQLSLATEEELQDLAEELE 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1001 SFSSQILTLQKQSAFLQEHTTTLQTQTAKLQVENSTLSSQN--------------------------------------- 1041
Cdd:COG4717   203 ELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEErlkearlllliaaallallglggsllsliltiagvlflv 282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1042 -AALSAQYTVLQSQQAAKEAEHEGLQQQQEQLAAVYEALLQDHKHLGTLYECQSSEYEALIRQHSCLKTLHRNLELEHKE 1120
Cdd:COG4717   283 lGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEE 362

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1121 LgerhgDLQQRKAELEEL-EKVLSTEREALEReqktNAIATSENQRLRGELDRIS-FLHQQLKGEYEELHAHTKE-LKTS 1197
Cdd:COG4717   363 L-----QLEELEQEIAALlAEAGVEDEEELRA----ALEQAEEYQELKEELEELEeQLEELLGELEELLEALDEEeLEEE 433

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1198 LNNSQLELSRWQVRFDELKEQHQSMDISLTKMDNhcellSRLKGNLEEENHHLLSQIQLLSQQNQ--MLLEQNMESKEQY 1275
Cdd:COG4717   434 LEELEEELEELEEELEELREELAELEAELEQLEE-----DGELAELLQELEELKAELRELAEEWAalKLALELLEEAREE 508


                  ....*.
gi 755543021 1276 HEEQKQ 1281
Cdd:COG4717   509 YREERL 514
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 116-578 1.80e-05

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 50.12  E-value: 1.80e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   116 HLRRLIDERDecteliVDLTQERDYLQTQQPPSPGKFSSpDSTPSPTSSLSSEDKQHLAVELADTKARLRRVRQELEEKT 195
Cdd:pfam15921  416 HLRRELDDRN------MEVQRLEALLKAMKSECQGQMER-QMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKK 488

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   196 EQLADTRHEVDQLVLELQKAKqdniqlaadaRSARAYRDELDSLREKanrverleMDLvrckeKLHDVDFYKARMEELRE 275
Cdd:pfam15921  489 MTLESSERTVSDLTASLQEKE----------RAIEATNAEITKLRSR--------VDL-----KLQELQHLKNEGDHLRN 545

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   276 dniilIETKAmleEQLTASRARSDKVHELEKENLQLKSKLHDlELDRDADKKQIEKlleeymvlemaqKQSMKESAHLGW 355
Cdd:pfam15921  546 -----VQTEC---EALKLQMAEKDKVIEILRQQIENMTQLVG-QHGRTAGAMQVEK------------AQLEKEINDRRL 604

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   356 ELEQLSKNADLSDASRKSFvfelnecaSSRILKLEKENQSL-QSTIQGLRDTSLALEESSLKYGELEKENQQLSKKIEKL 434
Cdd:pfam15921  605 ELQEFKILKDKKDAKIREL--------EARVSDLELEKVKLvNAGSERLRAVKDIKQERDQLLNEVKTSRNELNSLSEDY 676

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   435 QTQLEREKQSNQDLETLSEELireKEQLQSGMEALKADRaRQIKDLEQEKGHLHQAVWSLR-----ERPQVNStkdVEKE 509
Cdd:pfam15921  677 EVLKRNFRNKSEEMETTTNKL---KMQLKSAQSELEQTR-NTLKSMEGSDGHAMKVAMGMQkqitaKRGQIDA---LQSK 749

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   510 NRALHQAVTEAGSKLSQLELEKQQLHRDLEE-AKEKGEQAealeKELHRLEKENEQLTKEVTSLKAATEK 578
Cdd:pfam15921  750 IQFLEEAMTNANKEKHFLKEEKNKLSQELSTvATEKNKMA----GELEVLRSQERRLKEKVANMEVALDK 815
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
974-1173 1.83e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 49.63  E-value: 1.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  974 LERSNAALQAERQLLKEQLQHLEtqnvsfsSQILTLQKQ-SAFLQEHtttlqtQTAKLQVENSTLSSQNAALSAQYTVLQ 1052
Cdd:COG3206   166 LELRREEARKALEFLEEQLPELR-------KELEEAEAAlEEFRQKN------GLVDLSEEAKLLLQQLSELESQLAEAR 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1053 SQQAAKEAEHEGLQQQQEQLAAVYEALLQDhkhlgtlyecqsSEYEALIRQhscLKTLHRNLELEHKELGERHGDLQQRK 1132
Cdd:COG3206   233 AELAEAEARLAALRAQLGSGPDALPELLQS------------PVIQQLRAQ---LAELEAELAELSARYTPNHPDVIALR 297

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 755543021 1133 AELEELEKVLSTEREALEREQKTN-AIATSENQRLRGELDRI 1173
Cdd:COG3206   298 AQIAALRAQLQQEAQRILASLEAElEALQAREASLQAQLAQL 339
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
703-1205 2.09e-05

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 49.65  E-value: 2.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  703 LQRELSQLEAERQALRRDLETLQLTHKQLEGAEEDRKALEQEVAQLEKDKKLLEKE----ARRLWQQVELKDAILDDSAA 778
Cdd:PRK02224  218 LDEEIERYEEQREQARETRDEADEVLEEHEERREELETLEAEIEDLRETIAETEREreelAEEVRDLRERLEELEEERDD 297

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  779 KLSAAEKESRALDKELARCRDVGSKLKELEKDNRDLTKQVTMHTRTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGL 858
Cdd:PRK02224  298 LLAEAGLDDADAEAVEARREELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEARE 377

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  859 SKDlllqeddghgDGKGKTEsALKTTLAMKEEKIVFLEAQVEEKESLSRQLQIELQMIKKEHEQLRQTQEGGDK--AQNA 936
Cdd:PRK02224  378 AVE----------DRREEIE-ELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAELEATLRTARErvEEAE 446

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  937 LKRPPGKV-TSHQEKEawEPSHKEATMEllrVKDRAIELERSNAALQAERQLLKEQLQHLETQnVSFSSQILTLQKQSAF 1015
Cdd:PRK02224  447 ALLEAGKCpECGQPVE--GSPHVETIEE---DRERVEELEAELEDLEEEVEEVEERLERAEDL-VEAEDRIERLEERRED 520

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1016 LQEHTTTLQTQTAKLQVENSTLSSQNAALSAQYTVLQSQQAAKEAEHEGLQQQQEQLAAVYEALLQDHKHLGTLYECQsS 1095
Cdd:PRK02224  521 LEELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLERIRTLL-A 599

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1096 EYEALIRQHSCLKTLHRNLELEHKELGERHGDLQQRKAELEEL--EKVLSTEREALEREQKTNAIATSENQRLRGELDRI 1173
Cdd:PRK02224  600 AIADAEDEIERLREKREALAELNDERRERLAEKRERKRELEAEfdEARIEEAREDKERAEEYLEQVEEKLDELREERDDL 679

                         490       500       510
                  ....*....|....*....|....*....|..
gi 755543021 1174 SFLHQQLKGEYEELHAHTKELKtSLNNSQLEL 1205
Cdd:PRK02224  680 QAEIGAVENELEELEELRERRE-ALENRVEAL 710
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 391-787 2.33e-05

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 49.12  E-value: 2.33e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   391 KENQSLQSTIQGLRDT-SLALEESSLKYGELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEAl 469
Cdd:pfam07888  104 KELSASSEELSEEKDAlLAQRAAHEARIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEEAERKQLQAKLQQ- 182

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   470 kadrarqikdleqekghlhqavwslrerpqvnstkdVEKENRALHQAVTEAGSKLSQLELEKQQLHRDLEEAKEKGEQAe 549
Cdd:pfam07888  183 ------------------------------------TEEELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTA- 225

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   550 alekelHRLEKENEQLTKEVTSLKaatEKVEALEHQSQGLELENRSLRKSLDTLQnvsvqlEGLERDKQQLGQENLELRK 629
Cdd:pfam07888  226 ------HRKEAENEALLEELRSLQ---ERLNASERKVEGLGEELSSMAAQRDRTQ------AELHQARLQAAQLTLQLAD 290

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   630 MVEAMRFTSAKMAQietenrqlerEKEELRRDVELLKtlskksERLElsyqSVSAENLQLQHSLESSTHKSQALQRELS- 708
Cdd:pfam07888  291 ASLALREGRARWAQ----------ERETLQQSAEADK------DRIE----KLSAELQRLEERLQEERMEREKLEVELGr 350

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   709 -------QLEAERQALRRDLETLQLTHKQLEGAEEDRKALEQEVAQLEKDkklLEKEARRLWQQVELKDAILDDSAakLS 781
Cdd:pfam07888  351 ekdcnrvQLSESRRELQELKASLRVAQKEKEQLQAEKQELLEYIRQLEQR---LETVADAKWSEAALTSTERPDSP--LS 425


                   ....*.
gi 755543021   782 AAEKES 787
Cdd:pfam07888  426 DSEDEN 431
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
649-1079 2.97e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 49.00  E-value: 2.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  649 RQLEREKEELRRDVELLKTLSKKSERlelsYQSVSAENLQLQHSLESSTHKSQALQRELSQLE---------AERQALRR 719
Cdd:COG4717    64 RKPELNLKELKELEEELKEAEEKEEE----YAELQEELEELEEELEELEAELEELREELEKLEkllqllplyQELEALEA 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  720 DLETLQLTHKQLEGAEEDRKALEQEVAQLEKDKKLLEKEARRLWQQVEL-KDAILDDSAAKLSAAEKESRALDKELARCR 798
Cdd:COG4717   140 ELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLaTEEELQDLAEELEELQQRLAELEEELEEAQ 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  799 DVGSKLK------ELEKDNRDLTKQVTMHTRTLTTLREDLVLEKLKSQQLSSELD-------------KLSQELEKVGLS 859
Cdd:COG4717   220 EELEELEeeleqlENELEAAALEERLKEARLLLLIAAALLALLGLGGSLLSLILTiagvlflvlgllaLLFLLLAREKAS 299

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  860 KDLLLQEDDGHGDGKGKTESALKTTLAMKEEKIVFLEAQVEEKESLSRQLQIELQMIKKEHEQLRQtQEGGDKAQNALKR 939
Cdd:COG4717   300 LGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQL-EELEQEIAALLAE 378

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  940 ppGKVTSHQEKEAWEPSHKEAtMELLRvkdraiELERSNAALQAERQLLKEQLQHLETQNVsfSSQILTLQKQSAFLQEH 1019
Cdd:COG4717   379 --AGVEDEEELRAALEQAEEY-QELKE------ELEELEEQLEELLGELEELLEALDEEEL--EEELEELEEELEELEEE 447

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1020 TTTLQTQTAKLQVENSTLSSQNAalsaqYTVLQSQQAAKEAEHEGLQQQQEQLAAVYEAL 1079
Cdd:COG4717   448 LEELREELAELEAELEQLEEDGE-----LAELLQELEELKAELRELAEEWAALKLALELL 502
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 528-787 3.39e-05

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 48.80  E-value: 3.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  528 ELEKQQLHRDLEEAKEKGEQAEALEKELHRLEKENEQLTKEVtSLKAATEKVEALEHQSQGLELENRSLRKSLDTLQNVS 607
Cdd:COG5185   264 DLRLEKLGENAESSKRLNENANNLIKQFENTKEKIAEYTKSI-DIKKATESLEEQLAAAEAEQELEESKRETETGIQNLT 342

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  608 VQLEGLERDKQQLGQENLELRKMVEAMRFTSAKMAQIETENRQLEREKEELRRDV-ELLKTLSKKSERLELSYQSVSAEN 686
Cdd:COG5185   343 AEIEQGQESLTENLEAIKEEIENIVGEVELSKSSEELDSFKDTIESTKESLDEIPqNQRGYAQEILATLEDTLKAADRQI 422

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  687 LQLQHSLESSTHKSQALQRELSQLEAERQALRR---DLETLQLTHKQLEGAEEDR-------KALEQEVAQLEKDKKLLE 756
Cdd:COG5185   423 EELQRQIEQATSSNEEVSKLLNELISELNKVMReadEESQSRLEEAYDEINRSVRskkedlnEELTQIESRVSTLKATLE 502

                         250       260       270
                  ....*....|....*....|....*....|.
gi 755543021  757 KEARRLWQQVELKDAILDDSAAKLSAAEKES 787
Cdd:COG5185   503 KLRAKLERQLEGVRSKLDQVAESLKDFMRAR 533
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 440-825 3.61e-05

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 49.18  E-value: 3.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  440 REKQsnqdLETLSEELIREKEQL-QSGMEALKADRARQikDLEQEKGhLHQAVW----------SLRERPQvnstkDVEK 508
Cdd:COG3096   783 REKR----LEELRAERDELAEQYaKASFDVQKLQRLHQ--AFSQFVG-GHLAVAfapdpeaelaALRQRRS-----ELER 850

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  509 ENRALHQAVTEAGSKLSQLELEKQQLHRDL---------------EEAKEKGEQAEALEKELHRLEKENEQLTKEVTSLK 573
Cdd:COG3096   851 ELAQHRAQEQQLRQQLDQLKEQLQLLNKLLpqanlladetladrlEELREELDAAQEAQAFIQQHGKALAQLEPLVAVLQ 930

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  574 AATEKVEALEHQSQGLELENRSLRKSLDTLQNVSVQLEGLE-RDKQQLGQENlelRKMVEAMRftsakmaqietenRQLE 652
Cdd:COG3096   931 SDPEQFEQLQADYLQAKEQQRRLKQQIFALSEVVQRRPHFSyEDAVGLLGEN---SDLNEKLR-------------ARLE 994

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  653 REKEELRRDVELLKtlskkserlelSYQSVSAENLQLQHSLESSthkSQALQRELSQLEAERQALrrdleTLQLTHKQLE 732
Cdd:COG3096   995 QAEEARREAREQLR-----------QAQAQYSQYNQVLASLKSS---RDAKQQTLQELEQELEEL-----GVQADAEAEE 1055

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  733 GAEEDRKALEQEVAQLEKDKKLLEKearrlwqQVELKDAILDDSAAKLSAAEKESRALDKELARCRDVGSKLKELEKDNr 812
Cdd:COG3096  1056 RARIRRDELHEELSQNRSRRSQLEK-------QLTRCEAEMDSLQKRLRKAERDYKQEREQVVQAKAGWCAVLRLARDN- 1127

                         410
                  ....*....|...
gi 755543021  813 DLTKQVtmHTRTL 825
Cdd:COG3096  1128 DVERRL--HRREL 1138
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
803-1238 4.20e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 48.61  E-value: 4.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  803 KLKELEKDNRDLTKQVtmhtRTLTTLREDLvleklksQQLSSELDKLSQELEKVGLSKDLLLQEDDGHGDGKGKteSALK 882
Cdd:COG4717    72 ELKELEEELKEAEEKE----EEYAELQEEL-------EELEEELEELEAELEELREELEKLEKLLQLLPLYQEL--EALE 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  883 TTLAMKEEKIVFLEAQVEEKESLSRQLQIELQMIKKEHEQLRQTQEGgdkaqnalkrppgkvTSHQEKEAWEpshkEATM 962
Cdd:COG4717   139 AELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQ---------------LSLATEEELQ----DLAE 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  963 ELLRVKDRAIELERSNAALQAERQLLKEQLQHLETQNVSFSSQiLTLQKQSAFLQEHTTTLQTQTAKLQVENSTLSSQNA 1042
Cdd:COG4717   200 ELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALE-ERLKEARLLLLIAAALLALLGLGGSLLSLILTIAGV 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1043 A------LSAQYTVLQSQQAAKEAEHEGLQQQQEQLAAVYEALLQDHKHLGTLYECQSSEYEALIRQHSCLKTLHRNLEL 1116
Cdd:COG4717   279 LflvlglLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEE 358

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1117 EHKEL---------------------------GERHGDLQQRKAELEELEKVLSTEREALEREQKTN--AIATSENQRLR 1167
Cdd:COG4717   359 LEEELqleeleqeiaallaeagvedeeelraaLEQAEEYQELKEELEELEEQLEELLGELEELLEALdeEELEEELEELE 438

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755543021 1168 GELDRISFLHQQLKGEYEELHAHTKELKTSLNNSQLELSRWQV--RFDELKEQHQSMDISLTKMDNHCELLSR 1238
Cdd:COG4717   439 EELEELEEELEELREELAELEAELEQLEEDGELAELLQELEELkaELRELAEEWAALKLALELLEEAREEYRE 511
HkD_Hook1 cd22225
Hook domain found in protein Hook 1 (Hook1) and similar proteins; Hook1 is a ...
 40-83 4.74e-05

Hook domain found in protein Hook 1 (Hook1) and similar proteins; Hook1 is a microtubule-binding protein required for spermatid differentiation. It is a component of the FTS/Hook/FHIP complex (FHF complex), which may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting (HOPS) complex.


Pssm-ID: 411796  Cd Length: 150  Bit Score: 45.61  E-value: 4.74e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 755543021   40 EIKKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEV 83
Cdd:cd22225   103 ELGRLLQLILGCAVNCEKKQEHIQNIMTLEESVQHVVMTAIQEL 146
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
 435-1086 5.34e-05

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 48.26  E-value: 5.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  435 QTQLEREKQSNQDLETLSEElirEKEQLQSGMEALKADRARQIKDLEQEKGHLHqavWSLRERPQVNSTKDVEKENRALH 514
Cdd:PRK10246  197 RTELEKLQAQASGVALLTPE---QVQSLTASLQVLTDEEKQLLTAQQQQQQSLN---WLTRLDELQQEASRRQQALQQAL 270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  515 QAVTEAGSKLSQLELekQQLHRDLEEAKEK-GEQAEALEKELHRLEKENEQLtKEVTSLKAATEKVEALEHQSQGLEL-- 591
Cdd:PRK10246  271 AAEEKAQPQLAALSL--AQPARQLRPHWERiQEQSAALAHTRQQIEEVNTRL-QSTMALRARIRHHAAKQSAELQAQQqs 347

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  592 ------ENRSLRKSLDTLQNVSVQLEGLERDKQQLGQEN---LELRKMVEAMRFTSAKM-AQIETENRQLEREKEELR-R 660
Cdd:PRK10246  348 lntwlaEHDRFRQWNNELAGWRAQFSQQTSDREQLRQWQqqlTHAEQKLNALPAITLTLtADEVAAALAQHAEQRPLRqR 427

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  661 DVELLKTLSKKSERLElsyqsvsaenlQLQHSLessthksQALQRELSQLEAERQALRRDLETLQ---LTHKQLEGAEED 737
Cdd:PRK10246  428 LVALHGQIVPQQKRLA-----------QLQVAI-------QNVTQEQTQRNAALNEMRQRYKEKTqqlADVKTICEQEAR 489

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  738 RKALEQEVAQLEKDKKLL-----EKEARRLWQQVELkdailDDSAAKLSAAEKESRALDKELARCRDvgsklkELEKdnr 812
Cdd:PRK10246  490 IKDLEAQRAQLQAGQPCPlcgstSHPAVEAYQALEP-----GVNQSRLDALEKEVKKLGEEGAALRG------QLDA--- 555

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  813 dLTKQVTMHTRTLTTLREDlvleklkSQQLSSELDKLSqelekvglskdlllqeddghgdgkgkteSALKTTLAMKEEKI 892
Cdd:PRK10246  556 -LTKQLQRDESEAQSLRQE-------EQALTQQWQAVC----------------------------ASLNITLQPQDDIQ 599

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  893 VFLEAQVE---------EKESLSRQLQIELQMIKKEHEQLRQTQEGGDKAQNALKRP---PGKVTS-----HQEKEAWEP 955
Cdd:PRK10246  600 PWLDAQEEherqlrllsQRHELQGQIAAHNQQIIQYQQQIEQRQQQLLTALAGYALTlpqEDEEASwlatrQQEAQSWQQ 679

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  956 SHKEAT---MELLRVKDRAIELERSNAALQAERQLLKEQLQHLETQNVSFSSQILTLQKQSAFLQEHTTTLQTQ-TAKLQ 1031
Cdd:PRK10246  680 RQNELTalqNRIQQLTPLLETLPQSDDLPHSEETVALDNWRQVHEQCLSLHSQLQTLQQQDVLEAQRLQKAQAQfDTALQ 759

                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1032 veNSTLSSQNAALSA-----QYTVLQSQQAAKEAEHEglqqQQEQLAAVYEALLQDHKHL 1086
Cdd:PRK10246  760 --ASVFDDQQAFLAAlldeeTLTQLEQLKQNLENQRQ----QAQTLVTQTAQALAQHQQH 813
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 516-770 5.63e-05

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 47.50  E-value: 5.63e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   516 AVTEAGSKLSQLELEKQQLHRDLEEAKEKgeqaeALEKELHRLEKENEQLTKEVTSLKAATEKVEA-----------LEH 584
Cdd:pfam15905   48 STPATARKVKSLELKKKSQKNLKESKDQK-----ELEKEIRALVQERGEQDKRLQALEEELEKVEAklnaavrektsLSA 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   585 QSQGLELENRSLRKSLDTLQNvSVQLEGLERDKQQLGQENLELRKMVEA-MRFTSAKMAQIETENRQLEREKEELRRDVE 663
Cdd:pfam15905  123 SVASLEKQLLELTRVNELLKA-KFSEDGTQKKMSSLSMELMKLRNKLEAkMKEVMAKQEGMEGKLQVTQKNLEHSKGKVA 201

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   664 LLKTLSKKSERLELSYQSVSAENLQLQHSLESSTHKSQALQRELSQLEAERQALRRDLETLQLThkqlegAEEDRKALEQ 743
Cdd:pfam15905  202 QLEEKLVSTEKEKIEEKSETEKLLEYITELSCVSEQVEKYKLDIAQLEELLKEKNDEIESLKQS------LEEKEQELSK 275

                          250       260
                   ....*....|....*....|....*..
gi 755543021   744 EVAQLEKDKKLLEKEARRLWQQVELKD 770
Cdd:pfam15905  276 QIKDLNEKCKLLESEKEELLREYEEKE 302
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 176-469 8.46e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 47.74  E-value: 8.46e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   176 ELADTKARLRRVRQELEEkteqladtrhevdqlvlelqKAKQDNIQLAADARSARAYRDELDSLREKA----NRVERLEM 251
Cdd:TIGR02168  772 EAEEELAEAEAEIEELEA--------------------QIEQLKEELKALREALDELRAELTLLNEEAanlrERLESLER 831

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   252 DLVRCKEKLHDVDFYKARMEELREDNIilietkamleeqltasrarsdkvHELEkenlqlksklhDLELDRDADKKQIEK 331
Cdd:TIGR02168  832 RIAATERRLEDLEEQIEELSEDIESLA-----------------------AEIE-----------ELEELIEELESELEA 877

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   332 LLEEYMVLEMAQKQSMKESAHLGWELEQLSKNADLSDASRKsfvfELNECASSRILKLEKENQSLQSTIQGLR-DTSLAL 410
Cdd:TIGR02168  878 LLNERASLEEALALLRSELEELSEELRELESKRSELRRELE----ELREKLAQLELRLEGLEVRIDNLQERLSeEYSLTL 953

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755543021   411 EESSLKYGELEKENQQLSKKIEKLQTQL--------------EREKQSNQDLETLSEELIREKEQLQSGMEAL 469
Cdd:TIGR02168  954 EEAEALENKIEDDEEEARRRLKRLENKIkelgpvnlaaieeyEELKERYDFLTAQKEDLTEAKETLEEAIEEI 1026
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 979-1228 8.70e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 47.07  E-value: 8.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  979 AALQAERQLLKEQLQHLETQNVSFSSQILTLQKQSAFLQEHTTTLQTQTAKLQVENSTLSSQNAALSAQYTVLQSQQAAK 1058
Cdd:COG4942    16 AAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAEL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1059 EAEHEGLQqqqeqlaAVYEALLQDHKHLGtlyecQSSEYEALIRQHSCLKTLHRNLELEH--KELGERHGDLQQRKAELE 1136
Cdd:COG4942    96 RAELEAQK-------EELAELLRALYRLG-----RQPPLALLLSPEDFLDAVRRLQYLKYlaPARREQAEELRADLAELA 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1137 ELEKVLSTEREALEREQKTNAiatSENQRLRGELDRISFLHQQLKGEYEELHAHTKELKTSLNNSQLELSRWQVRFDELK 1216
Cdd:COG4942   164 ALRAELEAERAELEALLAELE---EERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAA 240

                         250
                  ....*....|..
gi 755543021 1217 EQHQSMDISLTK 1228
Cdd:COG4942   241 ERTPAAGFAALK 252
hsdR PRK11448
type I restriction enzyme EcoKI subunit R; Provisional
 694-801 9.17e-05

type I restriction enzyme EcoKI subunit R; Provisional


Pssm-ID: 236912 [Multi-domain]  Cd Length: 1123  Bit Score: 47.64  E-value: 9.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  694 ESSTHKSQALQRELSQLEAERQALRRDLETLQlthKQLEGAEEDRKALEQEVAQLEKDKKLLEKEARRLWQQVELKDA-- 771
Cdd:PRK11448  138 EDPENLLHALQQEVLTLKQQLELQAREKAQSQ---ALAEAQQQELVALEGLAAELEEKQQELEAQLEQLQEKAAETSQer 214

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 755543021  772 ------ILDDSAAKLSAAEKESRAL-DKELarcRDVG 801
Cdd:PRK11448  215 kqkrkeITDQAAKRLELSEEETRILiDQQL---RKAG 248
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 175-619 9.25e-05

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 47.53  E-value: 9.25e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   175 VELADTKARLRRVRQELEEKTEQLADTRHevdQLVLELQKAKQDNIQ-LAADARSARAYRDELDSLREKANRVERLEMDL 253
Cdd:pfam12128  506 EALRQASRRLEERQSALDELELQLFPQAG---TLLHFLRKEAPDWEQsIGKVISPELLHRTDLDPEVWDGSVGGELNLYG 582

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   254 VRCKEKLHDVDFYKARMEELREDniilietKAMLEEQLTASRarsDKVHELEKENLQLksklhdleldrdadKKQIEKLL 333
Cdd:pfam12128  583 VKLDLKRIDVPEWAASEEELRER-------LDKAEEALQSAR---EKQAAAEEQLVQA--------------NGELEKAS 638

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   334 EEYMVLEMAQKQSMKESAHLGWELEQLSKNADLSDASRKSFVFElnecassRILKLEKENQSLQSTIQglrdtsLALEes 413
Cdd:pfam12128  639 REETFARTALKNARLDLRRLFDEKQSEKDKKNKALAERKDSANE-------RLNSLEAQLKQLDKKHQ------AWLE-- 703

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   414 slkygelEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEALKADRARQIK----------DLEQE 483
Cdd:pfam12128  704 -------EQKEQKREARTEKQAYWQVVEGALDAQLALLKAAIAARRSGAKAELKALETWYKRDLAslgvdpdviaKLKRE 776

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   484 KGHLHQAVWSL-RERPQVNSTKDVEKENRALHQ---AVTEAGSKLSQLELeKQQLHRDLEEAKekgEQAEALEKELHRLE 559
Cdd:pfam12128  777 IRTLERKIERIaVRRQEVLRYFDWYQETWLQRRprlATQLSNIERAISEL-QQQLARLIADTK---LRRAKLEMERKASE 852

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   560 KENEQLTKEVTSLKAATEKVEALeHQSQGLELENRSLRKSLDTLQNVSVQLEGLERDKQQ 619
Cdd:pfam12128  853 KQQVRLSENLRGLRCEMSKLATL-KEDANSEQAQGSIGERLAQLEDLKLKRDYLSESVKK 911
HkD_Hook3 cd22226
Hook domain found in protein Hook 3 (Hook3) and similar proteins; Hook3 is an adaptor protein ...
 40-83 9.32e-05

Hook domain found in protein Hook 3 (Hook3) and similar proteins; Hook3 is an adaptor protein for microtubule-dependent intracellular vesicle and protein trafficking. It is involved in Golgi and endosome transport. It acts as a scaffold for the opposite-polarity microtubule-based motors cytoplasmic dynein-1 and the kinesin KIF1C. It may participate in the turnover of the endocytosed scavenger receptor. Hook3 is a component of the FTS/Hook/FHIP complex (FHF complex), which may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting (HOPS) complex.


Pssm-ID: 411797  Cd Length: 153  Bit Score: 44.57  E-value: 9.32e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 755543021   40 EIKKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEV 83
Cdd:cd22226   107 ELGRMLQLILGCAVNCEQKQEYIQTIMMMEESVQHVVMTAIQEL 150
GOLGA2L5 pfam15070
Putative golgin subfamily A member 2-like protein 5; The function of the GOLGA2L5 protein ...
 461-931 1.02e-04

Putative golgin subfamily A member 2-like protein 5; The function of the GOLGA2L5 protein family remains unknown. This family of proteins is thought to be found in the Golgi apparatus of eukaryotes.


Pssm-ID: 464485 [Multi-domain]  Cd Length: 521  Bit Score: 46.98  E-value: 1.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   461 QLQSGMEALKADRARQIKDLEQEKGHLHQAVWSLRErpQVNSTKDvEKENRALHQAVTEAgsklSQLELEKQQLHRDLEE 540
Cdd:pfam15070    1 QLMESLKQLQTERDQYAENLKEEGAVWQQKMQQLSE--QVRTLRE-EKERSVSQVQELET----SLAELKNQAAVPPAEE 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   541 AKEKG---EQAEALEKELHRLEKENEQLTKEvtsLKAATEKVEALEHQSQglELENRslrksldtlqnvsvqLEGLERDK 617
Cdd:pfam15070   74 EQPPAgpsEEEQRLQEEAEQLQKELEALAGQ---LQAQVQDNEQLSRLNQ--EQEQR---------------LLELERAA 133

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   618 QQLGQENLELRKMVEAMRFTSAKMAQIETENRQLEREKEELRRdvellktlskkserlelSYQSVSAENLQLQHSLESST 697
Cdd:pfam15070  134 ERWGEQAEDRKQILEDMQSDRATISRALSQNRELKEQLAELQN-----------------GFVKLTNENMELTSALQSEQ 196

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   698 HKSQALQRELSQLEAERQALRrdlETLQLTHKQLEGAEEDRKA----LEQEVA---QLEKDKKLLEKEarrLWQQVELKD 770
Cdd:pfam15070  197 HVKKELAKKLGQLQEELGELK---ETLELKSQEAQSLQEQRDQylahLQQYVAayqQLASEKEELHKQ---YLLQTQLMD 270

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   771 AILDDSAAKLSAAEKESraldKELARCRDvgsKLKELEKDNRDLTKQvtmhtrtlttlredlvlekLKSQQLSSELDKL- 849
Cdd:pfam15070  271 RLQHEEVQGKVAAEMAR----QELQETQE---RLEALTQQNQQLQAQ-------------------LSLLANPGEGDGLe 324

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   850 SQELEKVGLSKDLLLQEDdghGDGKGKTESALKTTLAMKEEKIVFLEAQVEEKESLSRQLQIELQMIKKEHEQLRQTQEG 929
Cdd:pfam15070  325 SEEEEEEAPRPSLSIPED---FESREAMVAFFNSALAQAEEERAELRRQLKEQKRRCRRLAQQAAPAQEEPEHEAHAPGT 401


                   ..
gi 755543021   930 GD 931
Cdd:pfam15070  402 GG 403
TMCO5 pfam14992
TMCO5 family; The TMCO5 family includes human transmembrane and coiled-coil domain-containing ...
 675-849 1.03e-04

TMCO5 family; The TMCO5 family includes human transmembrane and coiled-coil domain-containing proteins 5A and 5B.


Pssm-ID: 464427 [Multi-domain]  Cd Length: 278  Bit Score: 46.25  E-value: 1.03e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   675 LELSYQSVSAENLQLQHSLESSTHKSQALQRELSQLEAERQALRRDLETLQLTHKqlegaEEDRKALEQEVAQLEKDKKL 754
Cdd:pfam14992    8 LEKDLQRLDEANQVLLLKIQEKEEEIQSLEREITLTRSLAEDEEREELNFTIMEK-----EDALQELELETAKLEKKNEI 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   755 L--------EKEARRLWQQVELK----DAILDDSAAKLSAAEkESRAL-DKELARCRDVGSKLKELEKDNRDLTKQVTMH 821
Cdd:pfam14992   83 LvksvmelqRKLSRKSDKNTGLEqetlKQMLEELKVKLQQSE-ESCADqEKELAKVESDYQSVHQLCEDQALCIKKYQEI 161

                          170       180       190
                   ....*....|....*....|....*....|
gi 755543021   822 TRTLTTLREDLVLEK--LKSQQLSSELDKL 849
Cdd:pfam14992  162 LRKMEEEKETRLLEKevSKAQSNSSQRVKL 191
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 171-755 1.07e-04

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 47.12  E-value: 1.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   171 QHLAVELADTKARLRRVRQELEEKTEQLAD-TRHEVDQLVLELQKAKqdniqLAADARSARAYRDELDSLREKA--NRVE 247
Cdd:pfam10174  195 GHLEVLLDQKEKENIHLREELHRRNQLQPDpAKTKALQTVIEMKDTK-----ISSLERNIRDLEDEVQMLKTNGllHTED 269

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   248 RLE----MDLVRCKEKlhdvdFYKARMEELREDniilietkamleeqltasrarsdkVHELEKENLQLKSKLHDLELDRD 323
Cdd:pfam10174  270 REEeikqMEVYKSHSK-----FMKNKIDQLKQE------------------------LSKKESELLALQTKLETLTNQNS 320

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   324 ADKKQIEKLLEEYMVLEmaqkqsmKESAHLGWELEQLSKNADlsdaSRKSFvfeLNEcASSRILKLEKENQSLQSTIQGL 403
Cdd:pfam10174  321 DCKQHIEVLKESLTAKE-------QRAAILQTEVDALRLRLE----EKESF---LNK-KTKQLQDLTEEKSTLAGEIRDL 385

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   404 RDTslaLEESSLKYGELEKENQQLSKKIEKLQTQLEREKQSNQDLETLS----------EELIREKEQLqsgMEALKADR 473
Cdd:pfam10174  386 KDM---LDVKERKINVLQKKIENLQEQLRDKDKQLAGLKERVKSLQTDSsntdtalttlEEALSEKERI---IERLKEQR 459

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   474 AR-------QIKDLEQEKGHLHQAVWSLRER--PQVNSTKDVEKENRALHQAVTEAGSKLSQLELEKQQlhrdleeakeK 544
Cdd:pfam10174  460 ERedrerleELESLKKENKDLKEKVSALQPEltEKESSLIDLKEHASSLASSGLKKDSKLKSLEIAVEQ----------K 529

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   545 GEQAEALEKELhrleKENEQLTKEVTSLKAATEKVEALEHQSQGLELENRSLRKSLDTLQNV--SVQLEGLERDKQQLGQ 622
Cdd:pfam10174  530 KEECSKLENQL----KKAHNAEEAVRTNPEINDRIRLLEQEVARYKEESGKAQAEVERLLGIlrEVENEKNDKDKKIAEL 605

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   623 ENLELRKMVE-AMRFTSAKMAQIETENRQLE------REKEELRRDV------ELLKTLSKKSERLELSYQSVSAenlqL 689
Cdd:pfam10174  606 ESLTLRQMKEqNKKVANIKHGQQEMKKKGAQlleearRREDNLADNSqqlqleELMGALEKTRQELDATKARLSS----T 681

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   690 QHSLESSthksqalQRELSQLEAERqalRRDLETLqLTHKQ----------------LEGAEEDRKALEQEVAQLEKDKK 753
Cdd:pfam10174  682 QQSLAEK-------DGHLTNLRAER---RKQLEEI-LEMKQeallaaisekdanialLELSSSKKKKTQEEVMALKREKD 750


                   ..
gi 755543021   754 LL 755
Cdd:pfam10174  751 RL 752
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
966-1187 1.25e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 46.93  E-value: 1.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  966 RVKDRAIELERSNAALQAERQLLKEQLQHLETQNVSF--SSQILTLQKQSAFLQEHTTTLQTQTAKLQVENSTLSSQNAA 1043
Cdd:COG3206   165 NLELRREEARKALEFLEEQLPELRKELEEAEAALEEFrqKNGLVDLSEEAKLLLQQLSELESQLAEARAELAEAEARLAA 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1044 LSAQyTVLQSQQAAKEAEHEGLQQQQEQLAAVyEALLQDhkhLGTLYECQSSEYEALIRQhscLKTLHRNLElehKELGE 1123
Cdd:COG3206   245 LRAQ-LGSGPDALPELLQSPVIQQLRAQLAEL-EAELAE---LSARYTPNHPDVIALRAQ---IAALRAQLQ---QEAQR 313

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755543021 1124 RHGDLQQRKAELEELEKVLSTEREALEREQKTNAIATSENQRLRGELDRISFLHQQLKGEYEEL 1187
Cdd:COG3206   314 ILASLEAELEALQAREASLQAQLAQLEARLAELPELEAELRRLEREVEVARELYESLLQRLEEA 377
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
 177-558 1.32e-04

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 46.77  E-value: 1.32e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   177 LADTKARLRRVRQELEEKTEQLADTRHEVDQLVLELQKAKqdniqlaadaRSARAYRDEL-DSLREKANRVERLEMDLVR 255
Cdd:pfam06160   95 LDDIEEDIKQILEELDELLESEEKNREEVEELKDKYRELR----------KTLLANRFSYgPAIDELEKQLAEIEEEFSQ 164

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   256 CKEKLHDVDFYKARM--EELREDNI-----------ILIETKAMLEEQLTASRARSDK----------------VHELEK 306
Cdd:pfam06160  165 FEELTESGDYLEAREvlEKLEEETDaleelmedippLYEELKTELPDQLEELKEGYREmeeegyalehlnvdkeIQQLEE 244

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   307 ENLQLKSKLHDLELDRDADK-KQIEKLLEE-YMVLE---MAQKQSMKESAHLGWELEQLSKNAD--LSDASRKSFVFELN 379
Cdd:pfam06160  245 QLEENLALLENLELDEAEEAlEEIEERIDQlYDLLEkevDAKKYVEKNLPEIEDYLEHAEEQNKelKEELERVQQSYTLN 324

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   380 ECASSRILKLEKENQSLQSTIQGLRDtslALEESSLKYGELEKENQQLSKKIEKLQTQLEREKQSNQDLETlSEELIREK 459
Cdd:pfam06160  325 ENELERVRGLEKQLEELEKRYDEIVE---RLEEKEVAYSELQEELEEILEQLEEIEEEQEEFKESLQSLRK-DELEAREK 400

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   460 -EQLQSGMEALKadraRQIkdleqEKGHLhqavwslrerPQVNST-----KDVEKENRALHQavteagsKLSQLELEKQQ 533
Cdd:pfam06160  401 lDEFKLELREIK----RLV-----EKSNL----------PGLPESyldyfFDVSDEIEDLAD-------ELNEVPLNMDE 454

                          410       420
                   ....*....|....*....|....*
gi 755543021   534 LHRDLEEAKekgEQAEALEKELHRL 558
Cdd:pfam06160  455 VNRLLDEAQ---DDVDTLYEKTEEL 476
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
512-794 1.40e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 46.43  E-value: 1.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  512 ALHQAVTEAGSKLSQLELEKQQLHRDLEEAKEkgeQAEALEKELHRLEKENEQLTKEVT----SLKAATEKVEALEHQSQ 587
Cdd:COG4372    28 ALSEQLRKALFELDKLQEELEQLREELEQARE---ELEQLEEELEQARSELEQLEEELEelneQLQAAQAELAQAQEELE 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  588 GLELENRSLRKSLDTLQNvsvQLEGLERDKQQLGQENLELRKMVeamrftSAKMAQIETENRQLEREKEELRRDVELLKT 667
Cdd:COG4372   105 SLQEEAEELQEELEELQK---ERQDLEQQRKQLEAQIAELQSEI------AEREEELKELEEQLESLQEELAALEQELQA 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  668 LSKKSERLELSYQSVSAENLQLQHSLESSTHKSQALQRELSQLEAERQALRRDLETLQLTHKQLEGAEEDRKALEQEVAQ 747
Cdd:COG4372   176 LSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEV 255

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 755543021  748 LEKDKKLLEKEARRLWQQVELKDAILDDSAAKLSAAEKESRALDKEL 794
Cdd:COG4372   256 ILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLL 302
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1672-1923 1.58e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 47.09  E-value: 1.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1672 EAEALAGMPSRQV-----QPPQSLSLGRPRQTtmtqnchmpVSRSASLSRAFSLASadllRASGPEACRPESPQKPGGHE 1746
Cdd:PHA03307   12 EAAAEGGEFFPRPpatpgDAADDLLSGSQGQL---------VSDSAELAAVTVVAG----AAACDRFEPPTGPPPGPGTE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1747 AAGARETSTHSLQGSHILAR-ERTPIVGKADSPSPGQGT----------------RGRPLDTRRFSLAPPKEERLAPLQQ 1809
Cdd:PHA03307   79 APANESRSTPTWSLSTLAPAsPAREGSPTPPGPSSPDPPpptpppaspppspapdLSEMLRPVGSPGPPPAASPPAAGAS 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1810 SATAPALATGCSSGSNPqiqhfSPTVAPAVRTKSKVPqhsgevATVAPVRPGLGTSEGDGGPGHGYSEG--LLTKSPGRS 1887
Cdd:PHA03307  159 PAAVASDAASSRQAALP-----LSSPEETARAPSSPP------AEPPPSTPPAAASPRPPRRSSPISASasSPAPAPGRS 227

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 755543021 1888 SDLPPHVKRGPDDFSQGSSSKSTPASPEPGGDPQTV 1923
Cdd:PHA03307  228 AADDAGASSSDSSSSESSGCGWGPENECPLPRPAPI 263
HAP1_N pfam04849
HAP1 N-terminal conserved region; This family represents an N-terminal conserved region found ...
 419-600 1.63e-04

HAP1 N-terminal conserved region; This family represents an N-terminal conserved region found in several huntingtin-associated protein 1 (HAP1) homologs. HAP1 binds to huntingtin in a polyglutamine repeat-length-dependent manner. However, its possible role in the pathogenesis of Huntington's disease is unclear. This family also includes a similar N-terminal conserved region from hypothetical protein products of ALS2CR3 genes found in the human juvenile amyotrophic lateral sclerosis critical region 2q33-2q34.


Pssm-ID: 461455 [Multi-domain]  Cd Length: 309  Bit Score: 45.79  E-value: 1.63e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   419 ELEKENQQLSKKIEKLQTQLereKQSNQDLETLSEELIREKEQLQ----SGMEALKADRARQIKDLEQEKGHLHQAVW-- 492
Cdd:pfam04849   91 SLLKQNSVLTERNEALEEQL---GSAREEILQLRHELSKKDDLLQiysnDAEESETESSCSTPLRRNESFSSLHGCVQld 167

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   493 SLRERpqvnsTKDVEKENRALHQAVTEAGSKLSQLELEKQQLHRDL-EEAKEKGEQAEALEKELHRLEKENEQLTKEVTS 571
Cdd:pfam04849  168 ALQEK-----LRGLEEENLKLRSEASHLKTETDTYEEKEQQLMSDCvEQLSEANQQMAELSEELARKMEENLRQQEEITS 242

                          170       180
                   ....*....|....*....|....*....
gi 755543021   572 LKAateKVEALEHQSQGLELENRSLRKSL 600
Cdd:pfam04849  243 LLA---QIVDLQHKCKELGIENEELQQHL 268
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 838-1082 1.74e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 45.91  E-value: 1.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  838 KSQQLSSELDKLSQELEKvgLSKDLLLQEddghgdgkgKTESALKTTLAMKEEKIVFLEAQVEEKESLSRQLQIELQMIK 917
Cdd:COG4942    21 AAAEAEAELEQLQQEIAE--LEKELAALK---------KEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELE 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  918 KEHEQLRQTQEggdKAQNALKRppgkvtshQEKEAWEPSHKEATMELLRVKDrAIELERSNAALQAERQLLKEQLQHLEt 997
Cdd:COG4942    90 KEIAELRAELE---AQKEELAE--------LLRALYRLGRQPPLALLLSPED-FLDAVRRLQYLKYLAPARREQAEELR- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  998 qnvsfsSQILTLQKQSAFLQEHTTTLQTQTAKLQVENSTLSSQNAALSAQYTVLQSQQAAKEAEHEGLQQQQEQLAAVYE 1077
Cdd:COG4942   157 ------ADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIA 230


                  ....*
gi 755543021 1078 ALLQD 1082
Cdd:COG4942   231 RLEAE 235
Filament pfam00038
Intermediate filament protein;
652-910 1.76e-04

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 45.68  E-value: 1.76e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   652 EREKEELRRdveLLKTLSKKSERLELSYQSVSAENLQLQHSLESSTHKSQALqrelsqlEAERQALRRDLETLQLTHKQL 731
Cdd:pfam00038   53 EKEIEDLRR---QLDTLTVERARLQLELDNLRLAAEDFRQKYEDELNLRTSA-------ENDLVGLRKDLDEATLARVDL 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   732 EGAEEdrkALEQEVAQLekdKKLLEKEARRLWQQVELKDAILD-DSAAK--LSAAEKESRALDKELARCrdvgsKLKELE 808
Cdd:pfam00038  123 EAKIE---SLKEELAFL---KKNHEEEVRELQAQVSDTQVNVEmDAARKldLTSALAEIRAQYEEIAAK-----NREEAE 191

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   809 KDNR----DLTKQVTMHTRTLTTLREDLVLEKLKSQQLSSELDklSQELEKVGLSKDLLLQEDDGHGDgkgktesalktt 884
Cdd:pfam00038  192 EWYQskleELQQAAARNGDALRSAKEEITELRRTIQSLEIELQ--SLKKQKASLERQLAETEERYELQ------------ 257

                          250       260
                   ....*....|....*....|....*..
gi 755543021   885 LAMKEEKIVFLEAQVEE-KESLSRQLQ 910
Cdd:pfam00038  258 LADYQELISELEAELQEtRQEMARQLR 284
Macoilin pfam09726
Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 ...
 215-482 2.49e-04

Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 trasnmembrane helices, followed by a C-terminal coiled-coil region. Macoilin is a highly conserved protein present in eukaryotes. Macoilin appears to be found in the ER and be involved in the function of neurons.


Pssm-ID: 462859 [Multi-domain]  Cd Length: 670  Bit Score: 46.00  E-value: 2.49e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   215 AKQDNIQLAADARSARAYRDELDS-----LREKANRVERLEMDLVRCKEKLHdvdfyKARMEELredniiliETKAMLEE 289
Cdd:pfam09726  361 SKNSKKQKGPGGKSGARHKDPAENcipnnQLSKPDALVRLEQDIKKLKAELQ-----ASRQTEQ--------ELRSQISS 427

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   290 QLTASRARSDKVHELEKENLQLKSKLHDLELDRDADKK---QIEKLL-EEYMVLEMAQKQSMKESAHLGWELEQLSKNAD 365
Cdd:pfam09726  428 LTSLERSLKSELGQLRQENDLLQTKLHNAVSAKQKDKQtvqQLEKRLkAEQEARASAEKQLAEEKKRKKEEEATAARAVA 507

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   366 LSDASRKsfvfELNECASSRILKLEKENQSLQSTIQGLRDTSLALE---ESSLKYGELEKENQQL-------SKKIEKLQ 435
Cdd:pfam09726  508 LAAASRG----ECTESLKQRKRELESEIKKLTHDIKLKEEQIRELEikvQELRKYKESEKDTEVLmsalsamQDKNQHLE 583

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 755543021   436 TQLEREKQSNQDLETLSEELIREKEQLQSGMEAlkadRARQIKDLEQ 482
Cdd:pfam09726  584 NSLSAETRIKLDLFSALGDAKRQLEIAQGQIYQ----KDQEIKDLKQ 626
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 234-751 2.50e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 46.58  E-value: 2.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   234 DELDSLREKA-NRVERLEMDLVRCkEKLHDVDFYKARMEEL--REDNIIL-IETKAMLEEQLTA-----SRARSDK--VH 302
Cdd:TIGR01612 1132 KALEEIKKKSeNYIDEIKAQINDL-EDVADKAISNDDPEEIekKIENIVTkIDKKKNIYDEIKKllneiAEIEKDKtsLE 1210

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   303 ELEKENLQLKSKLHDLELDR-DADKKQIE---KLLEEYMV-LEMAQKQSMKESAHLGWELEQ------------------ 359
Cdd:TIGR01612 1211 EVKGINLSYGKNLGKLFLEKiDEEKKKSEhmiKAMEAYIEdLDEIKEKSPEIENEMGIEMDIkaemetfnishdddkdhh 1290

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   360 -LSKNAD--LSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLR-DTSLALEESS-----LKYGELEK---ENQQL 427
Cdd:TIGR01612 1291 iISKKHDenISDIREKSLKIIEDFSEESDINDIKKELQKNLLDAQKHNsDINLYLNEIAniyniLKLNKIKKiidEVKEY 1370

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   428 SKKIEKLQTQLEREKQSNQDL-ETLSEELIRE--KEQLQSGMEALKADRArqIKDLEQEKGHLhqavwsLRERPQVNS-- 502
Cdd:TIGR01612 1371 TKEIEENNKNIKDELDKSEKLiKKIKDDINLEecKSKIESTLDDKDIDEC--IKKIKELKNHI------LSEESNIDTyf 1442

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   503 -TKDVEKENRALHQAVTEAGSKLSQ--LELEKQQLHRD----LEEAKEKGEQAEALEKELhrlEKENEQLTKEVTSLKAA 575
Cdd:TIGR01612 1443 kNADENNENVLLLFKNIEMADNKSQhiLKIKKDNATNDhdfnINELKEHIDKSKGCKDEA---DKNAKAIEKNKELFEQY 1519

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   576 TEKVEALEHQSQGLELENRslrksldtlqnvsvqLEGLERDKQQLGQENLELRKMVEAMRFTS-AKMAQIETENRQLERE 654
Cdd:TIGR01612 1520 KKDVTELLNKYSALAIKNK---------------FAKTKKDSEIIIKEIKDAHKKFILEAEKSeQKIKEIKKEKFRIEDD 1584

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   655 KEELRRDVELLKTLSKKSERLELSYQSVS------AENLQLQHSLES--STHKSQALQRELSQLEAERQALRRDLETLQL 726
Cdd:TIGR01612 1585 AAKNDKSNKAAIDIQLSLENFENKFLKISdikkkiNDCLKETESIEKkiSSFSIDSQDTELKENGDNLNSLQEFLESLKD 1664

                          570       580
                   ....*....|....*....|....*
gi 755543021   727 THKQLEGAEEDRKALEQEVAQLEKD 751
Cdd:TIGR01612 1665 QKKNIEDKKKELDELDSEIEKIEID 1689
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 186-503 2.57e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 45.88  E-value: 2.57e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   186 RVRQELEEKTEQLADTRHevdqlVLELQKAKQDNIQ-----LAADARSARAYRDELDSLREKAnrvERLEMDLVRCKEKL 260
Cdd:pfam17380  300 RLRQEKEEKAREVERRRK-----LEEAEKARQAEMDrqaaiYAEQERMAMERERELERIRQEE---RKRELERIRQEEIA 371

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   261 HDVdfykARMEELREDNIILIETKAMLEEQLTASRarsdKVHELEKENlQLKSKLHDLELDRdADKKQIEKLLEEYMVLE 340
Cdd:pfam17380  372 MEI----SRMRELERLQMERQQKNERVRQELEAAR----KVKILEEER-QRKIQQQKVEMEQ-IRAEQEEARQREVRRLE 441

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   341 MAQKQSMKESAHLGWELEQLSKNADLSDASRKsfvfelnecasSRILKLEKENQSlQSTIQGLRDTSLALEESSLKYGEL 420
Cdd:pfam17380  442 EERAREMERVRLEEQERQQQVERLRQQEEERK-----------RKKLELEKEKRD-RKRAEEQRRKILEKELEERKQAMI 509

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   421 EKENQQ--LSKKIEKLQTQL-EREKQSNQDLETLSEELIREKEQLQSGMEALKADRARqIKDLEQEKGHLHQAVWSLRER 497
Cdd:pfam17380  510 EEERKRklLEKEMEERQKAIyEEERRREAEEERRKQQEMEERRRIQEQMRKATEERSR-LEAMEREREMMRQIVESEKAR 588


                   ....*.
gi 755543021   498 PQVNST 503
Cdd:pfam17380  589 AEYEAT 594
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 522-722 2.77e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 44.53  E-value: 2.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  522 SKLSQLELEKQQLHRDLEEAKEkgeQAEALEKELHRLEKENEQLTKEVTSLKAATEKVEALEHQSQGLELENRSLRKsld 601
Cdd:COG1579    17 SELDRLEHRLKELPAELAELED---ELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNNKE--- 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  602 tLQNVSVQLEGLERDKQQLGQENLELrkmveamrftsakMAQIETENRQLEREKEELRrdvELLKTLSKKSERLELsyqs 681
Cdd:COG1579    91 -YEALQKEIESLKRRISDLEDEILEL-------------MERIEELEEELAELEAELA---ELEAELEEKKAELDE---- 149

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 755543021  682 vsaenlqlqhslessthKSQALQRELSQLEAERQALRRDLE 722
Cdd:COG1579   150 -----------------ELAELEAELEELEAEREELAAKIP 173
PRK01156 PRK01156
chromosome segregation protein; Provisional
 356-809 2.83e-04

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 46.05  E-value: 2.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  356 ELEQLSKNADLSDASRKSFVFELnecasSRILKLEKEnqsLQSTIQGLRDTSLALEESSLKYGELEKENQQLSKKIEKLQ 435
Cdd:PRK01156  160 EINSLERNYDKLKDVIDMLRAEI-----SNIDYLEEK---LKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAM 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  436 TQLEREKQSNQDLETLSEELIREKEQLQS--GMEALKADRARQIKDLEQEKGHL-HQAVWSLRER--PQVNSTKDVEKEN 510
Cdd:PRK01156  232 DDYNNLKSALNELSSLEDMKNRYESEIKTaeSDLSMELEKNNYYKELEERHMKIiNDPVYKNRNYinDYFKYKNDIENKK 311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  511 RAlhqavteagskLSQLELEKQQLHrdleEAKEKGEQAEALEKELHRLEKENEQLTKEVTSLKAATEKVEALEHQSQGLE 590
Cdd:PRK01156  312 QI-----------LSNIDAEINKYH----AIIKKLSVLQKDYNDYIKKKSRYDDLNNQILELEGYEMDYNSYLKSIESLK 376

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  591 LENRSLRKSLDTLQN-VSVQLEGLERDKQQLGQENLELRKMVEAMrftSAKMAQIETENRQLEREKEELRRDVELLKTLS 669
Cdd:PRK01156  377 KKIEEYSKNIERMSAfISEILKIQEIDPDAIKKELNEINVKLQDI---SSKVSSLNQRIRALRENLDELSRNMEMLNGQS 453

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  670 K-----------KSERLELSYqsvSAENLQLQHSLESSTHKSQALQRELSQLEAERQAL-RRDLETLQLTHKQLEGAEED 737
Cdd:PRK01156  454 VcpvcgttlgeeKSNHIINHY---NEKKSRLEEKIREIEIEVKDIDEKIVDLKKRKEYLeSEEINKSINEYNKIESARAD 530

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755543021  738 RKALEQEVAQLeKDKKLLEKEARRLWQQVELKDaiLDDSAAKLSAAEKESRALDKELARCR--DVGSKLKELEK 809
Cdd:PRK01156  531 LEDIKIKINEL-KDKHDKYEEIKNRYKSLKLED--LDSKRTSWLNALAVISLIDIETNRSRsnEIKKQLNDLES 601
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 291-578 3.06e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 45.14  E-value: 3.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  291 LTASRARSDKVHELEKENLQLKSKLHDLELDRDADKKQIEKLLEeymvlemaqkqsmkesahlgwELEQLSKnadlsdas 370
Cdd:COG4942    12 ALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLK---------------------QLAALER-------- 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  371 rksfvfelnecassRILKLEKENQSLQSTIQGLRDTslaLEESSLKYGELEKENQQLSKKIEKLQTQLEREKQSNQDLET 450
Cdd:COG4942    63 --------------RIAALARRIRALEQELAALEAE---LAELEKEIAELRAELEAQKEELAELLRALYRLGRQPPLALL 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  451 LSEELIREKEQLQSGMEALKADRARQIKDLEQEKGHLHQAVWSLRERPQ--VNSTKDVEKENRALHQAVTEAGSKLSQLE 528
Cdd:COG4942   126 LSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAelEALLAELEEERAALEALKAERQKLLARLE 205

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 755543021  529 lekQQLHRDLEEAKEKGEQAEALEKELHRLEKENEQLTKEVTSLKAATEK 578
Cdd:COG4942   206 ---KELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAGFAALK 252
HAP1_N pfam04849
HAP1 N-terminal conserved region; This family represents an N-terminal conserved region found ...
 507-711 3.25e-04

HAP1 N-terminal conserved region; This family represents an N-terminal conserved region found in several huntingtin-associated protein 1 (HAP1) homologs. HAP1 binds to huntingtin in a polyglutamine repeat-length-dependent manner. However, its possible role in the pathogenesis of Huntington's disease is unclear. This family also includes a similar N-terminal conserved region from hypothetical protein products of ALS2CR3 genes found in the human juvenile amyotrophic lateral sclerosis critical region 2q33-2q34.


Pssm-ID: 461455 [Multi-domain]  Cd Length: 309  Bit Score: 45.02  E-value: 3.25e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   507 EKENRALHQAVTEAGSKLSQLELE---KQQLHRDLEEAKEKGEQAEALEKELHRLEKENEqLTKEVTslkaatekVEALE 583
Cdd:pfam04849  100 TERNEALEEQLGSAREEILQLRHElskKDDLLQIYSNDAEESETESSCSTPLRRNESFSS-LHGCVQ--------LDALQ 170

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   584 HQSQGLELENRSLRKSLDTLQNVSVQLEGLErdkQQLgqenleLRKMVEAMRFTSAKMAQIETEnrqLEREKEELRRDVE 663
Cdd:pfam04849  171 EKLRGLEEENLKLRSEASHLKTETDTYEEKE---QQL------MSDCVEQLSEANQQMAELSEE---LARKMEENLRQQE 238

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 755543021   664 LLKTLSKKSERLELSYQSVSAENLQLQHSLESSTHKSQALQRELSQLE 711
Cdd:pfam04849  239 EITSLLAQIVDLQHKCKELGIENEELQQHLQASKEAQRQLTSELQELQ 286
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
655-812 3.29e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 45.28  E-value: 3.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  655 KEELRRDVELLKTLSKKSERLELSYQSVSAENLQLQHSLESSTHKSQALQRELSQLEAERQALRRDLETLQlthKQLEGA 734
Cdd:COG4372    30 SEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQ---EELESL 106

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755543021  735 EEDRKALEQEVAQLEKDKKLLEKEARRLWQQVELKDAILDDSAAKLSAAEKESRALDKELARCRDVGSKLKELEKDNR 812
Cdd:COG4372   107 QEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQA 184
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
168-481 3.90e-04

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 45.42  E-value: 3.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  168 EDKQHLAVELADTKARLRRVRQELEEKTEQLADTRHEV--------------DQLVLELQKAKQDNIQLAADARSARAYR 233
Cdd:PRK02224  363 EEAAELESELEEAREAVEDRREEIEELEEEIEELRERFgdapvdlgnaedflEELREERDELREREAELEATLRTARERV 442

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  234 DE----------------------LDSLREKANRVERLEMDLVRCKEKLHDVDFYKARMEELR--EDNIILIETKAMLEE 289
Cdd:PRK02224  443 EEaealleagkcpecgqpvegsphVETIEEDRERVEELEAELEDLEEEVEEVEERLERAEDLVeaEDRIERLEERREDLE 522

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  290 QLTASR-----ARSDKVHELEKENLQLKSKLHDLELDRDADKKQIEKLLEEYMVLEMAQKQSMKESAHLGWELEQLSKNA 364
Cdd:PRK02224  523 ELIAERretieEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLERIRTLLAAIA 602

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  365 DLSDA-----SRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDTSL---------ALEESSLKYGELEKENQQLSKK 430
Cdd:PRK02224  603 DAEDEierlrEKREALAELNDERRERLAEKRERKRELEAEFDEARIEEAredkeraeeYLEQVEEKLDELREERDDLQAE 682

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 755543021  431 IEKLQTQLEREKQSNQDLETLSEELIR------EKEQLQSGMEALKAD-RARQIKDLE 481
Cdd:PRK02224  683 IGAVENELEELEELRERREALENRVEAlealydEAEELESMYGDLRAElRQRNVETLE 740
Tropomyosin pfam00261
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 ...
 639-854 4.41e-04

Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites. The protein is best known for its role in regulating the interaction between actin and myosin in muscle contraction, but is also involved in the organization and dynamics of the cytoskeleton in non-muscle cells. There are multiple cell-specific isoforms, expressed by alternative promoters and alternative RNA processing of at least four genes. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.


Pssm-ID: 459736 [Multi-domain]  Cd Length: 235  Bit Score: 43.86  E-value: 4.41e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   639 AKMAQIETEnrqLEREKEELRRDVELLKTLSKKSERLELSYQSVSAENLQLQHSLESSTHKSQALQRELSQLEA---ERQ 715
Cdd:pfam00261    1 KKMQQIKEE---LDEAEERLKEAMKKLEEAEKRAEKAEAEVAALNRRIQLLEEELERTEERLAEALEKLEEAEKaadESE 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   716 ALRRDLETlqlthkqlEGAEEDRKALEQEvAQLeKDKKLLEKEARRLWQQVELKDAI----LDDSAAKLSAAEKESRALD 791
Cdd:pfam00261   78 RGRKVLEN--------RALKDEEKMEILE-AQL-KEAKEIAEEADRKYEEVARKLVVvegdLERAEERAELAESKIVELE 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   792 KELA-------------------------RCRDVGSKLKELEKDNRDLTKQVTMHTRTLTTLREDLVLEKLKSQQLSSEL 846
Cdd:pfam00261  148 EELKvvgnnlksleaseekaseredkyeeQIRFLTEKLKEAETRAEFAERSVQKLEKEVDRLEDELEAEKEKYKAISEEL 227


                   ....*...
gi 755543021   847 DKLSQELE 854
Cdd:pfam00261  228 DQTLAELN 235
mukB PRK04863
chromosome partition protein MukB;
536-1009 4.51e-04

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 45.33  E-value: 4.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  536 RDLEEAKEKGEQAEALEKELHRLEKeneQLTKEVTSLKAATEKVEALEHQSQGLELENRSLRKSLDTLQNVSVQLEGLER 615
Cdd:PRK04863  276 RHANERRVHLEEALELRRELYTSRR---QLAAEQYRLVEMARELAELNEAESDLEQDYQAASDHLNLVQTALRQQEKIER 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  616 DKQQLGQENLELRKMVEAMRFTSAKMAQIETENRQLEREKEELRrdvellKTLSKKSERLElsyqsvsaenlqlqhsles 695
Cdd:PRK04863  353 YQADLEELEERLEEQNEVVEEADEQQEENEARAEAAEEEVDELK------SQLADYQQALD------------------- 407

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  696 sthksqALQRELSQLEAERQALRRDLETLQLTHKQLEGAEEdrkALEQEVAQLEKdkklLEKEARRLWQQVELKDAILD- 774
Cdd:PRK04863  408 ------VQQTRAIQYQQAVQALERAKQLCGLPDLTADNAED---WLEEFQAKEQE----ATEELLSLEQKLSVAQAAHSq 474

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  775 -DSAAKL--SAAEKESRALDKELARcrdvgSKLKELEKDnRDLTKQVTMHTRTLTTLREDLVLEKlksqqlssELDKLSQ 851
Cdd:PRK04863  475 fEQAYQLvrKIAGEVSRSEAWDVAR-----ELLRRLREQ-RHLAEQLQQLRMRLSELEQRLRQQQ--------RAERLLA 540

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  852 ELEKVglskdLLLQEDDghgdgkgktESALKTTLAMKEEKIVFLEAQVEEKESLSRQLQIELQMIKKEHEQLRQTQEGGD 931
Cdd:PRK04863  541 EFCKR-----LGKNLDD---------EDELEQLQEELEARLESLSESVSEARERRMALRQQLEQLQARIQRLAARAPAWL 606

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755543021  932 KAQNALKRppgkvTSHQEKEAWEPSHK-EATMELLRVKDRAIELERSNaaLQAERQLLKEQLQHLETQNVSFSSQILTL 1009
Cdd:PRK04863  607 AAQDALAR-----LREQSGEEFEDSQDvTEYMQQLLERERELTVERDE--LAARKQALDEEIERLSQPGGSEDPRLNAL 678
DUF4515 pfam14988
Domain of unknown function (DUF4515); This family of proteins is found in bacteria and ...
 528-726 5.65e-04

Domain of unknown function (DUF4515); This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 198 and 469 amino acids in length. There are two completely conserved L residues that may be functionally important.


Pssm-ID: 405647 [Multi-domain]  Cd Length: 206  Bit Score: 43.22  E-value: 5.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   528 ELEKQQLHRDlEEAKEKGEQAEALEKELHRLEKENEQLTKEVTSLKAATEKVEALEHQSQGLELENRSLRKSLDTLqnvs 607
Cdd:pfam14988   30 ECEEIERRRQ-ELASRYTQQTAELQTQLLQKEKEQASLKKELQALRPFAKLKESQEREIQDLEEEKEKVRAETAEK---- 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   608 vqlegLERDKQQLGQENLELRKMVEAMRFTSAKmaqietenrqlEREKEELRRDVELLKTLSKKSerLELSYQSVSAENL 687
Cdd:pfam14988  105 -----DREAHLQFLKEKALLEKQLQELRILELG-----------ERATRELKRKAQALKLAAKQA--LSEFCRSIKRENR 166

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 755543021   688 QLQHSLESSTHKSQALQRELSQLEAERQALRRDLETLQL 726
Cdd:pfam14988  167 QLQKELLQLIQETQALEAIKSKLENRKQRLKEEQWYLEA 205
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 439-1187 6.23e-04

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 44.94  E-value: 6.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  439 EREKQSNQDLEtLSEELIREKEQLQSGMEALkADRARQIKDLEQEKGHLHQAVWSLRERPQ--VNSTKDVEKENRaLHQA 516
Cdd:COG3096   279 ERRELSERALE-LRRELFGARRQLAEEQYRL-VEMARELEELSARESDLEQDYQAASDHLNlvQTALRQQEKIER-YQED 355

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  517 VTEAGSKLSQLELEKQQLHRDLEEAKEKGEQAEALEKEL-------------------------HRLEKENEQLTKEVTS 571
Cdd:COG3096   356 LEELTERLEEQEEVVEEAAEQLAEAEARLEAAEEEVDSLksqladyqqaldvqqtraiqyqqavQALEKARALCGLPDLT 435

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  572 LKAATEKVEALEHQSQGLELENRSLRKSLDTLQNVSVQ----LEGLER-----DKQQLGQENLELRKMVEAMRFTSAKMA 642
Cdd:COG3096   436 PENAEDYLAAFRAKEQQATEEVLELEQKLSVADAARRQfekaYELVCKiagevERSQAWQTARELLRRYRSQQALAQRLQ 515

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  643 QIETENRQLEREKEELRRDVELLKTLSKKS-------ERLELSYQSVSAENLQLQHSLESSTHKSQALQRELSQLEAERQ 715
Cdd:COG3096   516 QLRAQLAELEQRLRQQQNAERLLEEFCQRIgqqldaaEELEELLAELEAQLEELEEQAAEAVEQRSELRQQLEQLRARIK 595

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  716 ALRRD----------LETLQ-LTHKQLEGAEEDRKALEQevaQLEKdkkllEKEARRLWQQVELKDAILDDSAAKLSAAe 784
Cdd:COG3096   596 ELAARapawlaaqdaLERLReQSGEALADSQEVTAAMQQ---LLER-----EREATVERDELAARKQALESQIERLSQP- 666

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  785 keSRALDKELARCRDV--GSKLKELEKDnrdltkqVTMH-----TRTLTTLREDLVLEKLKSQQlsSELDKLSQELEkvg 857
Cdd:COG3096   667 --GGAEDPRLLALAERlgGVLLSEIYDD-------VTLEdapyfSALYGPARHAIVVPDLSAVK--EQLAGLEDCPE--- 732

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  858 lskDLLLQEddghGDGKGKTESALKTT---------------------------LAMKEEKIVFLEAQVEEKESLSRQLQ 910
Cdd:COG3096   733 ---DLYLIE----GDPDSFDDSVFDAEeledavvvklsdrqwrysrfpevplfgRAAREKRLEELRAERDELAEQYAKAS 805

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  911 IELQMIKKEHEQLRQTqeggdkaqnalkrppgkVTSHQEkEAWEPShKEATMELLRvkDRAIELERSNAALQAERQLLKE 990
Cdd:COG3096   806 FDVQKLQRLHQAFSQF-----------------VGGHLA-VAFAPD-PEAELAALR--QRRSELERELAQHRAQEQQLRQ 864

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  991 QLQHLETQnvsfSSQILTLQKQSAFLQEHTTTLQTQTAKLQVEnstlssqnAALSAQYTVLQSQQAAKEAEheglqqqqe 1070
Cdd:COG3096   865 QLDQLKEQ----LQLLNKLLPQANLLADETLADRLEELREELD--------AAQEAQAFIQQHGKALAQLE--------- 923

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1071 QLAAVYEALLQDHKHLGTLYECQSSEYEALIRQHSCLKTLHRNLE----LEHKELGERHGDLQQR-KAELEELEKVLSTE 1145
Cdd:COG3096   924 PLVAVLQSDPEQFEQLQADYLQAKEQQRRLKQQIFALSEVVQRRPhfsyEDAVGLLGENSDLNEKlRARLEQAEEARREA 1003

                         810       820       830       840
                  ....*....|....*....|....*....|....*....|..
gi 755543021 1146 REALEREQKTNAIATSENQRLRGELDRISFLHQQLKGEYEEL 1187
Cdd:COG3096  1004 REQLRQAQAQYSQYNQVLASLKSSRDAKQQTLQELEQELEEL 1045
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1114-1300 6.29e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 44.76  E-value: 6.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1114 LELEHKELGERHGDLQQRKAELEELEKvlstEREALEREQKtnaiatsenqRLRGELDRISFLHQqlkgeYEELHAHTKE 1193
Cdd:COG4717    76 LEEELKEAEEKEEEYAELQEELEELEE----ELEELEAELE----------ELREELEKLEKLLQ-----LLPLYQELEA 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1194 LKTSLNNSQLELSRWQVRFDELKEQHQSmdisltkmdnhcelLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMESKE 1273
Cdd:COG4717   137 LEAELAELPERLEELEERLEELRELEEE--------------LEELEAELAELQEELEELLEQLSLATEEELQDLAEELE 202

                         170       180
                  ....*....|....*....|....*..
gi 755543021 1274 QYHEEQKQYIDKLNALRRHKEKLEEKI 1300
Cdd:COG4717   203 ELQQRLAELEEELEEAQEELEELEEEL 229
TMCO5 pfam14992
TMCO5 family; The TMCO5 family includes human transmembrane and coiled-coil domain-containing ...
 420-629 6.65e-04

TMCO5 family; The TMCO5 family includes human transmembrane and coiled-coil domain-containing proteins 5A and 5B.


Pssm-ID: 464427 [Multi-domain]  Cd Length: 278  Bit Score: 43.94  E-value: 6.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   420 LEKENQQLSKKIEKLQTQLEREKQSNQDLE-----TLSEELIREKEQL-QSGMEalkadRARQIKDLEQEkghlhqavws 493
Cdd:pfam14992    8 LEKDLQRLDEANQVLLLKIQEKEEEIQSLEreitlTRSLAEDEEREELnFTIME-----KEDALQELELE---------- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   494 lrerpqvnsTKDVEKENRALHQAVTEAGSKLS-----QLELEKQQLHRDLEEAKEKGEQAEAL----EKELHRLEKENE- 563
Cdd:pfam14992   73 ---------TAKLEKKNEILVKSVMELQRKLSrksdkNTGLEQETLKQMLEELKVKLQQSEEScadqEKELAKVESDYQs 143

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755543021   564 --QLTKE-VTSLKAATEKVEALEHqsqglELENRSLRKSLDTLQNVSVQLEGLERDKQQLGQENLELRK 629
Cdd:pfam14992  144 vhQLCEDqALCIKKYQEILRKMEE-----EKETRLLEKEVSKAQSNSSQRVKLVETIQQNMEKTIIKKQ 207
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 873-1294 6.99e-04

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 44.81  E-value: 6.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   873 GKGKTESALKTTLAMKEeKIVFLEAQVEEKESLSRQLQIELQMIKKEHEQLRQTQEggdkaqnalkrppgkvtshqekea 952
Cdd:pfam10174  169 SKGLPKKSGEEDWERTR-RIAEAEMQLGHLEVLLDQKEKENIHLREELHRRNQLQP------------------------ 223

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   953 wEPSHKEATMELLRVKDRAI-ELERSNAALQAERQLLKEQLQHLETQNVSFSSQILTLQKQSAFLQEHTTTLQTQTAK-- 1029
Cdd:pfam10174  224 -DPAKTKALQTVIEMKDTKIsSLERNIRDLEDEVQMLKTNGLLHTEDREEEIKQMEVYKSHSKFMKNKIDQLKQELSKke 302

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1030 -----LQVENSTLSSQNAALSAQYTVLQSQQAAKEAEHEGLQQQQEQLAAVYEA----LLQDHKHLGTLYECQSSeyeal 1100
Cdd:pfam10174  303 sellaLQTKLETLTNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEkesfLNKKTKQLQDLTEEKST----- 377

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1101 irQHSCLKTLHRNLELEHKELGERHGDLQQRKAELEELEKVLSTEREALEREQKTN-----AIATSEN---------QRL 1166
Cdd:pfam10174  378 --LAGEIRDLKDMLDVKERKINVLQKKIENLQEQLRDKDKQLAGLKERVKSLQTDSsntdtALTTLEEalsekeriiERL 455

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1167 RGELDRisfLHQQLKGEYEELHAHTKELKTSLNNSQLELSRWQVRFDELKEQHQSMDISLTKMDNHcelLSRLKGNLEEE 1246
Cdd:pfam10174  456 KEQRER---EDRERLEELESLKKENKDLKEKVSALQPELTEKESSLIDLKEHASSLASSGLKKDSK---LKSLEIAVEQK 529

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*....
gi 755543021  1247 NHhllsqiQLLSQQNQMLLEQNMESKEQYHEEQKQYIDKL-NALRRHKE 1294
Cdd:pfam10174  530 KE------ECSKLENQLKKAHNAEEAVRTNPEINDRIRLLeQEVARYKE 572
PHA01351 PHA01351
putative minor structural protein
 525-862 7.37e-04

putative minor structural protein


Pssm-ID: 107029  Cd Length: 1070  Bit Score: 44.55  E-value: 7.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  525 SQLELEKQQLHRDLEEAKEKGEQAEALEKELHRLEKENEQLTKEVtslkaatekveaLEHQSQGLELENrSLRKSLDTLQ 604
Cdd:PHA01351  475 SQLIQTNQLLLRQLQQIVSLGIFDQKKIKEELKANKFNEQVALQI------------LESELQFAQLQN-QLKEYQFKLN 541

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  605 NVSVQLEGLERDKQQLGqenlelrkmveamrFTSAKMAQIETENRQLEREKEELRRDVELLKT--LSKKSER-------L 675
Cdd:PHA01351  542 NFLISPQDLEKDLKHLG--------------FDSAIISALIYENQVEQLIKFQLNNIESLAKKgyLSLDEIKkqfkaigI 607

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  676 ELSY--QSVSAENLQLQHSLESSTHKSQALQRELSQLEAERQALRRDLE------------TLQLTHKQLEGAEE----- 736
Cdd:PHA01351  608 IKEYedAFINFYNQELQISAFLTILKSQLRQFQIDPKEAETELKKLNINeylanqiiqeeyNINIAKLQLSVLETiaktl 687

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  737 --DRKALEQEVAQLEKDKKLLEKEARRLWqQVELKDAIlddSAAKLSAAEKesraldkelarcrDVGSKLKELEKDNRDL 814
Cdd:PHA01351  688 yyDQQQLSGELKKIHKDKTALELYITKFY-YEYIYPKI---SNYHLQLARH-------------GILSDISKLPKEVNDY 750

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 755543021  815 TKQVTMHTRTlTTLREDLVLEKLKSqqLSSELDKLSQELEKVGLSKDL 862
Cdd:PHA01351  751 EYKPAVLTYQ-TTLEIEYIKESLKD--LEIKPKTAINELEKLGMQKDI 795
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
179-469 7.46e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 44.52  E-value: 7.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  179 DTKARLRRVRQELeektEQLADTRHEVDQLVLELQKAKQDNIQLAADARSARAYRDELDSLREKANRVERLEmdlvrcke 258
Cdd:COG4913   607 DNRAKLAALEAEL----AELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVASAEREIAELE-------- 674

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  259 klhdvdfykARMEELREDNIILietkAMLEEQLTASRARSDkvhELEKENLQLKSKLHDLELDRDADKKQIEKLLEEymv 338
Cdd:COG4913   675 ---------AELERLDASSDDL----AALEEQLEELEAELE---ELEEELDELKGEIGRLEKELEQAEEELDELQDR--- 735

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  339 lemAQKQSMKESAHLGWELEQLSKNADLsDASRKSFVFELN---ECASSRILKLEKE--------NQSLQSTIQGLRDTS 407
Cdd:COG4913   736 ---LEAAEDLARLELRALLEERFAAALG-DAVERELRENLEeriDALRARLNRAEEEleramrafNREWPAETADLDADL 811

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755543021  408 LALEESSLKYGELEKENqqLSKKIEKLQTQLERekQSNQDLETLSEELIREKEQLQSGMEAL 469
Cdd:COG4913   812 ESLPEYLALLDRLEEDG--LPEYEERFKELLNE--NSIEFVADLLSKLRRAIREIKERIDPL 869
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 410-611 7.49e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.05  E-value: 7.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  410 LEESSLKYGELEKENQQLSKKIEKLQTQLErekQSNQDLETLSEELirekEQLQSGMEALKADRARQIKDLEQEKGHLHQ 489
Cdd:COG3883    18 IQAKQKELSELQAELEAAQAELDALQAELE---ELNEEYNELQAEL----EALQAEIDKLQAEIAEAEAEIEERREELGE 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  490 AVWSLRERPQVNSTKDVEKENRALHQAVT--EAGSKLSQLELEK-QQLHRDLEEAKEKGEQAEALEKELHRLEKENEQLT 566
Cdd:COG3883    91 RARALYRSGGSVSYLDVLLGSESFSDFLDrlSALSKIADADADLlEELKADKAELEAKKAELEAKLAELEALKAELEAAK 170

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 755543021  567 KEVTSLKA-ATEKVEALEHQSQGLELENRSLRKSLDTLQNVSVQLE 611
Cdd:COG3883   171 AELEAQQAeQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAA 216
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1368-1791 7.76e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 44.68  E-value: 7.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1368 ENPDNPPSGPNCVEERDTHNGP--------------------VGKGPGDLKPKRGSPRGGSVDRTDTSTDPAVKSWPSEP 1427
Cdd:PTZ00449  515 EASGLPPKAPGDKEGEEGEHEDskesdepkeggkpgetkegeVGKKPGPAKEHKPSKIPTLSKKPEFPKDPKHPKDPEEP 594

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1428 GSrtfSTSATTAALSSSTPIPKHLGRTKGCNSDDNLCEPSSePDGPYHRQQASRPNSLESSRNASSNSSPLSLK------ 1501
Cdd:PTZ00449  595 KK---PKRPRSAQRPTRPKSPKLPELLDIPKSPKRPESPKS-PKRPPPPQRPSSPERPEGPKIIKSPKPPKSPKppfdpk 670

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1502 -------GSSDHLHSRCESFSSADLIPSRDPATLSRDGNTSGRGLLGRHEYPPPRngPVSQEtiqkkgaaSTHTGVR-PH 1573
Cdd:PTZ00449  671 fkekfydDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKL--PRDEE--------FPFEPIGdPD 740

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1574 SASPS-SEMVTLEEflEESNRGGSPTHDTPScrDDLLSDYFrKAHDPPALGGQPGPPARKdgAKMPTSF------VAPTI 1646
Cdd:PTZ00449  741 AEQPDdIEFFTPPE--EERTFFHETPADTPL--PDILAEEF-KEEDIHAETGEPDEAMKR--PDSPSEHedkppgDHPSL 813

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1647 KMSINTSEGqqlkpghyvkpnLRPSEAEaLAGMPSRQVQPPQslslGRPrqttmtqnchMPVSRSASLSrafSLASADLL 1726
Cdd:PTZ00449  814 PKKRHRLDG------------LALSTTD-LESDAGRIAKDAS----GKI----------VKLKRSKSFD---DLTTVEEA 863

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755543021 1727 RASGPEACRPESPQkpgghEAAGARETSTHSLQGSHIL-ARERTPIVGKADSPSPGQGTRGRPLDT 1791
Cdd:PTZ00449  864 EEMGAEARKIVVDD-----DGTEADDEDTHPPEEKHKSeVRRRRPPKKPSKPKKPSKPKKPKKPDS 924
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 171-249 8.07e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.98  E-value: 8.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  171 QHLAVELADTKARLRRVRQELEEKTEQLADTRHEVDQLVLELQKAKQDNIQLAADARSAR-AYRDELDSLREKANRVERL 249
Cdd:COG4942   149 REQAEELRADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELaELAAELAELQQEAEELEAL 228
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 390-1007 8.56e-04

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 44.43  E-value: 8.56e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   390 EKENQSLQSTIQGLRDTSLALEE-SSLkygeLEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEA 468
Cdd:pfam10174   66 QEENQHLQLTIQALQDELRAQRDlNQL----LQQDFTTSPVDGEDKFSTPELTEENFRRLQSEHERQAKELFLLRKTLEE 141

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   469 LKAdrarQIKDLEQEKGHLHQAVWSLRERPQVNS-TKDVEKENRALHQAVTEAGSKLSQLELEKQQlhrdleeakeKGEQ 547
Cdd:pfam10174  142 MEL----RIETQKQTLGARDESIKKLLEMLQSKGlPKKSGEEDWERTRRIAEAEMQLGHLEVLLDQ----------KEKE 207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   548 AEALEKELHRlekeNEQLTKEVTSLKAATEKVEALEHQSQGLELENRSLRKSLDTLqNVSVQLEGLERdkqqlgQENLel 627
Cdd:pfam10174  208 NIHLREELHR----RNQLQPDPAKTKALQTVIEMKDTKISSLERNIRDLEDEVQML-KTNGLLHTEDR------EEEI-- 274

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   628 rKMVEAMRFTSAKMaqieteNRQLEREKEELRRDVELLKTLSKKSERLElSYQSVSAENLQ-LQHSLESSTHKSQALQRE 706
Cdd:pfam10174  275 -KQMEVYKSHSKFM------KNKIDQLKQELSKKESELLALQTKLETLT-NQNSDCKQHIEvLKESLTAKEQRAAILQTE 346

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   707 LSqleaerqALRRDLETLQ--LTHKQlegaeedrkaleQEVAQLEKDKKLLEKEARRLWQQVELKDAILDDSAAKLSAAE 784
Cdd:pfam10174  347 VD-------ALRLRLEEKEsfLNKKT------------KQLQDLTEEKSTLAGEIRDLKDMLDVKERKINVLQKKIENLQ 407

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   785 KESRALDKELARCRDvgsKLKELEKDnrdltkqvTMHTRT-LTTLREDL-----VLEKLKSQ------QLSSELDKLSQE 852
Cdd:pfam10174  408 EQLRDKDKQLAGLKE---RVKSLQTD--------SSNTDTaLTTLEEALsekerIIERLKEQreredrERLEELESLKKE 476

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   853 L----EKVGLSKDLLLQEDDGHGDGKGKTeSALKTTLAMKEEKIVFLEAQVEEKESLSRQLQIELQMIKKEHEQLRQTQE 928
Cdd:pfam10174  477 NkdlkEKVSALQPELTEKESSLIDLKEHA-SSLASSGLKKDSKLKSLEIAVEQKKEECSKLENQLKKAHNAEEAVRTNPE 555

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   929 GGDKAQNALKrppgKVTSHQEKEAWEPSHKEATMELLR-------VKDRAIELERSNAALQAERQLLK-EQLQHLETQNV 1000
Cdd:pfam10174  556 INDRIRLLEQ----EVARYKEESGKAQAEVERLLGILReveneknDKDKKIAELESLTLRQMKEQNKKvANIKHGQQEMK 631


                   ....*..
gi 755543021  1001 SFSSQIL 1007
Cdd:pfam10174  632 KKGAQLL 638
PLN02939 PLN02939
transferase, transferring glycosyl groups
 437-717 8.75e-04

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 44.51  E-value: 8.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  437 QLEREKQSNQDLETLSEELIREKEQLQSGMEALKADRARQIKDLEQ---EKGHLHQAVWSLRerpqvnsTKDVEKENRAL 513
Cdd:PLN02939  115 QQTNSKDGEQLSDFQLEDLVGMIQNAEKNILLLNQARLQALEDLEKiltEKEALQGKINILE-------MRLSETDARIK 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  514 HQAVTEAGSKLSQLELEKQQlHRDLEEAKEKGEQAEALEKELHRLEKEN-------EQLTKEVTSLKAATEKVEALEHQS 586
Cdd:PLN02939  188 LAAQEKIHVEILEEQLEKLR-NELLIRGATEGLCVHSLSKELDVLKEENmllkddiQFLKAELIEVAETEERVFKLEKER 266

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  587 QGLELENRSLRKSLDTLQNVSVQLEGLERDKQQLGQENLELrkMVEAMRFTSAKMAQIETENRQLEREKEELRRDVELLK 666
Cdd:PLN02939  267 SLLDASLRELESKFIVAQEDVSKLSPLQYDCWWEKVENLQD--LLDRATNQVEKAALVLDQNQDLRDKVDKLEASLKEAN 344

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  667 TLSKKSERLELSYQSVSAENLQLQHS-------LESSTHKSQALQRELSQL--EAERQAL 717
Cdd:PLN02939  345 VSKFSSYKVELLQQKLKLLEERLQASdheihsyIQLYQESIKEFQDTLSKLkeESKKRSL 404
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
388-633 8.91e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 43.74  E-value: 8.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  388 KLEKENQSLQSTIQGLRDTSLALEESSLKYGELEKENQQLSKKIEKLQTQLEREKQSNQDLEtlseeliREKEQLQSGME 467
Cdd:COG4372    67 ELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLE-------QQRKQLEAQIA 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  468 ALKADRARQIKDLEQEKGHLHQAVWSLRERPQVNSTKDVEKENRALHQAVTEAGSKLSQLELEKQQLHRDLEEAKEKGEQ 547
Cdd:COG4372   140 ELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEE 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  548 AEALEKELHRLEKENEQLTKEVTSLKAATEKVEALEHQSQGLELENRSLRKSLDTLQNVSVQLEGLERDKQQLGQENLEL 627
Cdd:COG4372   220 LLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLA 299


                  ....*.
gi 755543021  628 RKMVEA 633
Cdd:COG4372   300 LLLNLA 305
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 425-601 9.09e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 42.99  E-value: 9.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  425 QQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEALKADRARQIKDLEQEKGHLHqavwslRERPQVNSTK 504
Cdd:COG1579    13 QELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIK------KYEEQLGNVR 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  505 DvEKENRALHQAVTEAGSKLSQLElekqqlhrdlEEAKEKGEQAEALEKELHRLEKENEQLTKEVTSLKAA-TEKVEALE 583
Cdd:COG1579    87 N-NKEYEALQKEIESLKRRISDLE----------DEILELMERIEELEEELAELEAELAELEAELEEKKAElDEELAELE 155

                         170
                  ....*....|....*...
gi 755543021  584 HQSQGLELENRSLRKSLD 601
Cdd:COG1579   156 AELEELEAEREELAAKIP 173
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 505-667 9.09e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 42.99  E-value: 9.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  505 DVEKENRALHQAVTEAGSKLSQLELEKQQLHRDLEEAKekgEQAEALEKELHRLEKENEQLTKEVTSLKAATEKV----- 579
Cdd:COG1579    14 ELDSELDRLEHRLKELPAELAELEDELAALEARLEAAK---TELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVrnnke 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  580 -EALEHQSQGLELENRSLRkslDTLQNVSVQLEGLERDKQQLGQENLELRKMVEamrftsAKMAQIETENRQLEREKEEL 658
Cdd:COG1579    91 yEALQKEIESLKRRISDLE---DEILELMERIEELEEELAELEAELAELEAELE------EKKAELDEELAELEAELEEL 161


                  ....*....
gi 755543021  659 RRDVELLKT 667
Cdd:COG1579   162 EAEREELAA 170
PTZ00121 PTZ00121
MAEBL; Provisional
 536-958 1.00e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.36  E-value: 1.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  536 RDLEEAKEKGEQAEAL-EKELHRLEKENEQLTK-----EVTSLKA-----------ATEKVEALEHQSQGLELENRSLRK 598
Cdd:PTZ00121 1027 EKIEELTEYGNNDDVLkEKDIIDEDIDGNHEGKaeakaHVGQDEGlkpsykdfdfdAKEDNRADEATEEAFGKAEEAKKT 1106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  599 SLDTLQNVSVQLEGLERDKQQLGQEnlELRKMVEAMRFTSAKMAQiETENRQLEREKEELRRDVEllktlSKKSERLELS 678
Cdd:PTZ00121 1107 ETGKAEEARKAEEAKKKAEDARKAE--EARKAEDARKAEEARKAE-DAKRVEIARKAEDARKAEE-----ARKAEDAKKA 1178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  679 YQSVSAENLQLQHSLESSTHKSQAlqRELSQLEAERQAlrrdletlqlthKQLEGAEEDRKAleQEVAQLEKDKKLlEKE 758
Cdd:PTZ00121 1179 EAARKAEEVRKAEELRKAEDARKA--EAARKAEEERKA------------EEARKAEDAKKA--EAVKKAEEAKKD-AEE 1241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  759 ARRLwQQVELKDAILDDSAAKLSAAEKESRALDKELARCRDVGSKLKELEKDNrDLTKQVTMHtrtlttlREDLVLEKLK 838
Cdd:PTZ00121 1242 AKKA-EEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKAD-EAKKAEEKK-------KADEAKKKAE 1312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  839 SQQLSSELDKLSQELEKVGLSKDLLLQEDDGHGDGKGKTESALKTTLAMKEEKIVFLEAQVEEKESLSRQLQIELQMIKK 918
Cdd:PTZ00121 1313 EAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKK 1392

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 755543021  919 EHEQLRQTQEGGDKAQNALKRPPGKVTSHQEKEAWEPSHK 958
Cdd:PTZ00121 1393 ADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKK 1432
CCDC144C pfam14915
CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ...
 388-605 1.22e-03

CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ankyrin repeat domain-containing protein 26-like 1 found in eukaryotes. Its function remains unknown, however, it is known to contain a coiled-coil domain which corresponds to this region. The ankyrin repeat which features in this protein is a common amino acid motif.


Pssm-ID: 464371 [Multi-domain]  Cd Length: 304  Bit Score: 43.05  E-value: 1.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   388 KLEKENQSLQSTIQGLRDTsLALEESSLKYGELEKENQQLSKKIE--KLQTQLEREKQSnqdletlseelireKEQLQSG 465
Cdd:pfam14915   28 KYLEDIEILKEKNDDLQKT-LKLNEETLTKTVFQYNGQLNVLKAEntMLNSKLENEKQN--------------KERLETE 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   466 MEALKADRARQIKDLEQ-EKGHLHQAVWSLRERPQVNSTKD--------VEKENRALHQAVTEAGSKLSQLELEkqqLHR 536
Cdd:pfam14915   93 VESYRSRLAAAIQDHEQsQTSKRDLELAFQRERDEWLRLQDkmnfdvsnLRDENEILSQQLSKAESKANSLENE---LHR 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   537 DLEEAKEKG----------EQAEALEKEL-HRLEKENEQLTKevtslkaATEKVEALEHQSQGLELENRSLRKSLDTLQN 605
Cdd:pfam14915  170 TRDALREKTlllesvqrdlSQAQCQKKELeHMYQNEQDKVNK-------YIGKQESLEERLAQLQSENMLLRQQLEDAQN 242
PLN02939 PLN02939
transferase, transferring glycosyl groups
 604-853 1.45e-03

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 43.74  E-value: 1.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  604 QNVSVQLEGLERDKQQLGQENLELRKMVEA--------MRFTSAKMAQIETENRQLeREKEELRRDVELLKT-LSKKSER 674
Cdd:PLN02939  107 AIAAIDNEQQTNSKDGEQLSDFQLEDLVGMiqnaekniLLLNQARLQALEDLEKIL-TEKEALQGKINILEMrLSETDAR 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  675 LELSYQSVS--------AENLQLQHSLESSTHKS--QALQRELSQLEAERQALRRDLETL-------QLTHKQLEGAEED 737
Cdd:PLN02939  186 IKLAAQEKIhveileeqLEKLRNELLIRGATEGLcvHSLSKELDVLKEENMLLKDDIQFLkaelievAETEERVFKLEKE 265

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  738 RKALEQEVAQLEKD--------KKLLEKEARRLWQQVELKDAILDDSAAKlsaAEKESRALDKElarcRDVGSKLKELEK 809
Cdd:PLN02939  266 RSLLDASLRELESKfivaqedvSKLSPLQYDCWWEKVENLQDLLDRATNQ---VEKAALVLDQN----QDLRDKVDKLEA 338

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 755543021  810 DNRDltkqvtMHTRTLTTLREDLVLEKLKSqqLSSELDKLSQEL 853
Cdd:PLN02939  339 SLKE------ANVSKFSSYKVELLQQKLKL--LEERLQASDHEI 374
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
168-440 1.47e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 43.51  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  168 EDKQHLAVELADTKARLRRVRQELEEKTEqLADTRHEVDQL--------VLELQKAKQDNIQLAADARSARAYRDELDSL 239
Cdd:PRK03918  466 KELKEIEEKERKLRKELRELEKVLKKESE-LIKLKELAEQLkeleeklkKYNLEELEKKAEEYEKLKEKLIKLKGEIKSL 544

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  240 REKANRVERLEMDLVRCKEKLHDVDfykarmEELREDNIILIETKAMLEEQLtasrarSDKVHELE---KENLQLKSKLH 316
Cdd:PRK03918  545 KKELEKLEELKKKLAELEKKLDELE------EELAELLKELEELGFESVEEL------EERLKELEpfyNEYLELKDAEK 612

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  317 DLEldrdADKKQIEKLLEEymvLEMAQKQSMKESAhlgwELEQLSKNAdlsDASRKSFVFELNECASSRILKLEKENQSL 396
Cdd:PRK03918  613 ELE----REEKELKKLEEE---LDKAFEELAETEK----RLEELRKEL---EELEKKYSEEEYEELREEYLELSRELAGL 678

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 755543021  397 QSTIQGLRDTSLALEESSLKYGELEKENQQLSKKIEKLQTQLER 440
Cdd:PRK03918  679 RAELEELEKRREEIKKTLEKLKEELEEREKAKKELEKLEKALER 722
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
176-454 1.55e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 42.59  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  176 ELADTKARLRRVRQELEEKTEQLADTRHEVDQLVLELQKAKQDNIQLAAdarSARAYRDELDSLREKANRVERLEMDLVR 255
Cdd:COG1340    37 ELKELAEKRDELNAQVKELREEAQELREKRDELNEKVKELKEERDELNE---KLNELREELDELRKELAELNKAGGSIDK 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  256 CKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLtasrARSDKVHELEKENLQLKSKLHDLELDRDADKKQIEKLLEE 335
Cdd:COG1340   114 LRKEIERLEWRQQTEVLSPEEEKELVEKIKELEKEL----EKAKKALEKNEKLKELRAELKELRKEAEEIHKKIKELAEE 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  336 YMVLemaqKQSMKEsahLGWELEQLSKNADLSDASRKSFVFELNECaSSRILKLEKENQSLQSTIQGLRDTSLALEEssl 415
Cdd:COG1340   190 AQEL----HEEMIE---LYKEADELRKEADELHKEIVEAQEKADEL-HEEIIELQKELRELRKELKKLRKKQRALKR--- 258

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 755543021  416 kygelEKENQQLSKKIEKLQTQLER-EKQSNQDLETLSEE 454
Cdd:COG1340   259 -----EKEKEELEEKAEEIFEKLKKgEKLTTEELKLLQKS 293
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 424-856 1.58e-03

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 43.29  E-value: 1.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  424 NQQLSKkIEKL------QTQLEREKQSNQDLETLS----EELIREKEQLQSGMEALKAdrARQIKDLEQEKGHLHQAVWS 493
Cdd:PRK04778   47 NDELEK-VKKLnltgqsEEKFEEWRQKWDEIVTNSlpdiEEQLFEAEELNDKFRFRKA--KHEINEIESLLDLIEEDIEQ 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  494 LRErpQVNSTKDVEKENRALHQavteagsklsQLELEKQQLHRDLEEAKEK-GEQAEALEKELHRLEKENEQLTKEVTS- 571
Cdd:PRK04778  124 ILE--ELQELLESEEKNREEVE----------QLKDLYRELRKSLLANRFSfGPALDELEKQLENLEEEFSQFVELTESg 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  572 --LKAAtEKVEALEHQSQGLELENRSLRKSLDTLQNV-SVQLEGLERDKQQLGQEN---------LELRKMVEAMRFTSA 639
Cdd:PRK04778  192 dyVEAR-EILDQLEEELAALEQIMEEIPELLKELQTElPDQLQELKAGYRELVEEGyhldhldieKEIQDLKEQIDENLA 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  640 KMAQI-----ETENRQLEREKEEL----RRDVELLKTLSKKSERLELsyqsvsaenlQLQHSLESSTHksqaLQRELSQL 710
Cdd:PRK04778  271 LLEELdldeaEEKNEEIQERIDQLydilEREVKARKYVEKNSDTLPD----------FLEHAKEQNKE----LKEEIDRV 336

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  711 EaerqalrrdlETLQLTHKQLEgaeeDRKALEQEVAQLEKDKKLLEKEARRlwQQV---ELKDaILDDSAAKLSAAEKES 787
Cdd:PRK04778  337 K----------QSYTLNESELE----SVRQLEKQLESLEKQYDEITERIAE--QEIaysELQE-ELEEILKQLEEIEKEQ 399

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755543021  788 RALDKELARCRDVGS----KLKELEKDNRDLTKQvtMHTRTLTTLREDLVLEKlksQQLSSELDKLSQELEKV 856
Cdd:PRK04778  400 EKLSEMLQGLRKDELeareKLERYRNKLHEIKRY--LEKSNLPGLPEDYLEMF---FEVSDEIEALAEELEEK 467
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 539-789 1.63e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 42.89  E-value: 1.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  539 EEAKEKGEQAEALEKELHRLEKENEQLTKEVTSLKaatEKVEALEHQSQGLELENRSLRKSLDTLQNvsvQLEGLERDKQ 618
Cdd:COG3883    23 KELSELQAELEAAQAELDALQAELEELNEEYNELQ---AELEALQAEIDKLQAEIAEAEAEIEERRE---ELGERARALY 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  619 QLGQENLELRKMVEAMRFTSAkMAQIETENRQLEREKEELRRDVELLKTLSKKSERLElsyqsvsaenlqlqhslesstH 698
Cdd:COG3883    97 RSGGSVSYLDVLLGSESFSDF-LDRLSALSKIADADADLLEELKADKAELEAKKAELE---------------------A 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  699 KSQALQRELSQLEAERQALRRDLETLQlthKQLEGAEEDRKALEQEVAQLEKDKKLLEKEARRLWQQVELKDAILDDSAA 778
Cdd:COG3883   155 KLAELEALKAELEAAKAELEAQQAEQE---ALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAA 231

                         250
                  ....*....|.
gi 755543021  779 KLSAAEKESRA 789
Cdd:COG3883   232 AAAAAAAAAAA 242
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 734-936 1.86e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 42.89  E-value: 1.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  734 AEEDRKALEQEVAQLEKDKKLLEKEARRLWQQVELKDAILDDSAAKLSAAEKESRALDKELARCR-DVGSKLKELEKDNR 812
Cdd:COG3883    14 ADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEaEIEERREELGERAR 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  813 DLTKQ--------VTMHTRTLTTLREDL-VLEKLKSQQlSSELDKLSQELEKVGLSKDLLLQEddghgdgkgktESALKT 883
Cdd:COG3883    94 ALYRSggsvsyldVLLGSESFSDFLDRLsALSKIADAD-ADLLEELKADKAELEAKKAELEAK-----------LAELEA 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 755543021  884 TLAMKEEKIVFLEAQVEEKESLSRQLQIELQMIKKEHEQLRQTQEGGDKAQNA 936
Cdd:COG3883   162 LKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAA 214
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1010-1303 1.94e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 43.19  E-value: 1.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1010 QKQSAFLQEHTTTLQTQ-----TAKLQVENSTLSSQNAALSAQYTVLQSQQAAKEAEHEglqqqQEQLAAVYEALLQDHK 1084
Cdd:pfam17380  239 RKESFNLAEDVTTMTPEytvryNGQTMTENEFLNQLLHIVQHQKAVSERQQQEKFEKME-----QERLRQEKEEKAREVE 313

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1085 HLGTLYECQSSEYEALIRQHSCLK-----TLHRNLELEHKELGERHGDLQQ-RKAELE-ELEKVLSTEREALEREQKtna 1157
Cdd:pfam17380  314 RRRKLEEAEKARQAEMDRQAAIYAeqermAMERERELERIRQEERKRELERiRQEEIAmEISRMRELERLQMERQQK--- 390

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1158 iatseNQRLRGELD---RISFLHQQLKGEYEELHAHTKELKTSLNNS-QLELSRWQ---------VRFDELKEQHQsmdi 1224
Cdd:pfam17380  391 -----NERVRQELEaarKVKILEEERQRKIQQQKVEMEQIRAEQEEArQREVRRLEeeraremerVRLEEQERQQQ---- 461

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755543021  1225 sLTKMDNHCELLSRLKGNLEEENHhllsQIQLLSQQNQMLLEQNMESKEQYHEEQKQyidklnalrrhKEKLEEKIMDQ 1303
Cdd:pfam17380  462 -VERLRQQEEERKRKKLELEKEKR----DRKRAEEQRRKILEKELEERKQAMIEEER-----------KRKLLEKEMEE 524
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 1098-1302 2.06e-03

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 43.19  E-value: 2.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1098 EALIRQHSCLKTLHRNLELEHKELGERHGDLQQRKAELEELEKVLSTEREALEREQKTNAIATSENQRLRGELDRISFLH 1177
Cdd:pfam05557   27 RARIELEKKASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALREQAELNRLKKKYLEALNKKLNEKESQLADAREVI 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1178 QQLKGEyeelhahTKELKTSLNNSQLELSRWQVRFDELKEQHQSMDISLTKMDNHCELLSRLKGNLEEENHHLLSQIQLL 1257
Cdd:pfam05557  107 SCLKNE-------LSELRRQIQRAELELQSTNSELEELQERLDLLKAKASEAEQLRQNLEKQQSSLAEAEQRIKELEFEI 179

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 755543021  1258 SQQNQMLLE-QNMESK-------EQYHEEQKQYIDKLNALRRHKEKLEEKIMD 1302
Cdd:pfam05557  180 QSQEQDSEIvKNSKSElaripelEKELERLREHNKHLNENIENKLLLKEEVED 232
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 189-1344 2.24e-03

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 43.28  E-value: 2.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  189 QELEEKTEQLADTRHEVDQLVLELQKAKQDNIQLAADARSARAYRDELDSLREKANRVERLEMDLVRCKEklhDVDFYKA 268
Cdd:PTZ00440  522 KNIEDYYITIEGLKNEIEGLIELIKYYLQSIETLIKDEKLKRSMKNDIKNKIKYIEENVDHIKDIISLND---EIDNIIQ 598

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  269 RMEELREDNIILIETkamLEEQLTASRAR-SDKVHELEKENLQ--LKSKLHDLE----LDRDADKKQ-IEKLL----EEY 336
Cdd:PTZ00440  599 QIEELINEALFNKEK---FINEKNDLQEKvKYILNKFYKGDLQelLDELSHFLDdhkyLYHEAKSKEdLQTLLntskNEY 675

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  337 MVLEMAQKQSMKESAH-LGWELEQLSknaDLSDASRKSFVFELNECASSRILKLEKENQSLQStiqglrdtslALEESSL 415
Cdd:PTZ00440  676 EKLEFMKSDNIDNIIKnLKKELQNLL---SLKENIIKKQLNNIEQDISNSLNQYTIKYNDLKS----------SIEEYKE 742

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  416 KYGELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQsgmealkaDRARQIKDleqekghlhqavwslr 495
Cdd:PTZ00440  743 EEEKLEVYKHQIINRKNEFILHLYENDKDLPDGKNTYEEFLQYKDTIL--------NKENKISN---------------- 798

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  496 erpQVNSTKDvEKENRAlhqavteagSKLSQLELEKQQLHRDLEEAKEKGEQAEALEKElhrlEKENEQLTKEVTSLKAA 575
Cdd:PTZ00440  799 ---DINILKE-NKKNNQ---------DLLNSYNILIQKLEAHTEKNDEELKQLLQKFPT----EDENLNLKELEKEFNEN 861

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  576 TEKVEALEHQsqgLELENrslrKSLDTLQNVSVQLEGLERDKQQLgqENLeLRKMVEAMRFTSAKMAQIETENRQLEREK 655
Cdd:PTZ00440  862 NQIVDNIIKD---IENMN----KNINIIKTLNIAINRSNSNKQLV--EHL-LNNKIDLKNKLEQHMKIINTDNIIQKNEK 931

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  656 EelrrdvELLKTLSKKSERLE--LSYQSVSAENLQLQHSLESSTHKSQALQRE----LSQLEAER---QALRRDLETLQL 726
Cdd:PTZ00440  932 L------NLLNNLNKEKEKIEkqLSDTKINNLKMQIEKTLEYYDKSKENINGNdgthLEKLDKEKdewEHFKSEIDKLNV 1005

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  727 THKQLEGAEED--RKALEQEVAQLEKDKKLLEKEARrlwQQVELKDAILDDSAAKLSAAEKESralDKELARCRDVGSKL 804
Cdd:PTZ00440 1006 NYNILNKKIDDliKKQHDDIIELIDKLIKEKGKEIE---EKVDQYISLLEKMKTKLSSFHFNI---DIKKYKNPKIKEEI 1079

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  805 KELEKDNRDLTKQVTMHTRTLTTLredlvleKLKSQQLSSELDKLSQE-LEKVGLSKDLLlqeddghGDGKGKTESALKT 883
Cdd:PTZ00440 1080 KLLEEKVEALLKKIDENKNKLIEI-------KNKSHEHVVNADKEKNKqTEHYNKKKKSL-------EKIYKQMEKTLKE 1145

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  884 TLAMKEEKIVFLEaqVEEKESLSRQLQIEL--QMIKKE-------HEQLRQTQEGGDKAQNalkrppgKVTSHQEKEAWE 954
Cdd:PTZ00440 1146 LENMNLEDITLNE--VNEIEIEYERILIDHivEQINNEakksktiMEEIESYKKDIDQVKK-------NMSKERNDHLTT 1216

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  955 PSHKEATMELLRVKDRAIELERSNAALQAERQLLKeQLQHLETQNVSFSSQILTLQKQSAFLQEHTTTLQTQTAKLQVEN 1034
Cdd:PTZ00440 1217 FEYNAYYDKATASYENIEELTTEAKGLKGEANRST-NVDELKEIKLQVFSYLQQVIKENNKMENALHEIKNMYEFLISID 1295

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1035 STLSSQNAALSAQYTVLQSQQAAKEAEHEGlQQQQEQLAAVYEALLQDHKHLGTLYECQSSEYEALIRQ----------- 1103
Cdd:PTZ00440 1296 SEKILKEILNSTKKAEEFSNDAKKELEKTD-NLIKQVEAKIEQAKEHKNKIYGSLEDKQIDDEIKKIEQikeeisnkrke 1374

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1104 -HSCLKTLHRNlelehKELGERHGDLQQR-KAELEELEKvlsteREALERE--QKTNAIATSEN-QRLRGELDRISFLHQ 1178
Cdd:PTZ00440 1375 iNKYLSNIKSN-----KEKCDLHVRNASRgKDKIDFLNK-----HEAIEPSnsKEVNIIKITDNiNKCKQYSNEAMETEN 1444

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1179 QLKGEYEELHAHTKELKTSLNNS------------------------------QLELSRWQVRFDELKEQH--------- 1219
Cdd:PTZ00440 1445 KADENNDSIIKYEKEITNILNNSsilgkktklekkkkeatnimddingehsiiKTKLTKSSEKLNQLNEQPnikregdvl 1524

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1220 ---------QSMDISLTKMDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMESKEQYHEEQKQYIDKLNALR 1290
Cdd:PTZ00440 1525 nndkstiayETIQYNLGRVKHNLLNILNIKDEIETILNKAQDLMRDISKISKIVENKNLENLNDKEADYVKYLDNILKEK 1604

                        1210      1220      1230      1240      1250      1260
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755543021 1291 RHKEKLEEKIMDQYKFYDPAPK-----KKNHWIG----AKALVKLIKPKKEGSRERLKSTTDS 1344
Cdd:PTZ00440 1605 QLMEAEYKKLNEIYSDVDNIEKelkkhKKNYEIGllekVIEINKNIKLYMDSTKESLNSLVNN 1667
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 741-1298 2.52e-03

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 42.81  E-value: 2.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   741 LEQEVAQLEKDKKLLEKEARRlwQQVELkdailddsaakLSAAEKESRALDKELARCRDVGSKLKELEKdnRDLTKQvtm 820
Cdd:pfam05557    7 SKARLSQLQNEKKQMELEHKR--ARIEL-----------EKKASALKRQLDRESDRNQELQKRIRLLEK--REAEAE--- 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   821 htrtlTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLSKDLLLQeddghgdgKGKTESALKTTLAMKEEKivfLEAQVE 900
Cdd:pfam05557   69 -----EALREQAELNRLKKKYLEALNKKLNEKESQLADAREVISC--------LKNELSELRRQIQRAELE---LQSTNS 132

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   901 EKESLSRQLQiELQMIKKEHEQLRQTQEggdkaqnalkrppgkvTSHQEKEAWEPSHKEATMELLRVKDRAIELERSNAA 980
Cdd:pfam05557  133 ELEELQERLD-LLKAKASEAEQLRQNLE----------------KQQSSLAEAEQRIKELEFEIQSQEQDSEIVKNSKSE 195

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   981 LQAERQLLKEqLQHLETQNVSFSSQI---LTLQKQSAFLQ---EHTTTLQTQTAKLQVENSTLSSQnaalsaqytvLQSQ 1054
Cdd:pfam05557  196 LARIPELEKE-LERLREHNKHLNENIenkLLLKEEVEDLKrklEREEKYREEAATLELEKEKLEQE----------LQSW 264

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1055 QaaKEAEHEGLQQQQ-EQLAAVYEALLQDHKhlgtlyecqsseyeALIRQHSCLKTLHRNLELEHKELGErhgDLQQRKA 1133
Cdd:pfam05557  265 V--KLAQDTGLNLRSpEDLSRRIEQLQQREI--------------VLKEENSSLTSSARQLEKARRELEQ---ELAQYLK 325

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1134 ELEELEKVLSTEREALEREQKTNAIATSENQRLRGELDR------ISFLHQQLKGEYEELHAHTKELKTSLNNSQLELSR 1207
Cdd:pfam05557  326 KIEDLNKKLKRHKALVRRLQRRVLLLTKERDGYRAILESydkeltMSNYSPQLLERIEEAEDMTQKMQAHNEEMEAQLSV 405

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1208 WQVRFDELKEQHQSMDISLTKM---DNHCELLSRLKG--NLEEENHHLLSQIQLLSQQNQML------------------ 1264
Cdd:pfam05557  406 AEEELGGYKQQAQTLERELQALrqqESLADPSYSKEEvdSLRRKLETLELERQRLREQKNELemelerrclqgdydpkkt 485

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|
gi 755543021  1265 ----LEQN--MESKEQYHEEQKQYIDKLNALRRHKEKLEE 1298
Cdd:pfam05557  486 kvlhLSMNpaAEAYQQRKNQLEKLQAEIERLKRLLKKLED 525
LCD1 pfam09798
DNA damage checkpoint protein; This is a family of proteins which regulate checkpoint kinases. ...
 703-762 2.58e-03

DNA damage checkpoint protein; This is a family of proteins which regulate checkpoint kinases. In Schizosaccharomyces pombe this protein is called Rad26 and in Saccharomyces cerevisiae it is called LCD1.


Pssm-ID: 462906  Cd Length: 615  Bit Score: 42.69  E-value: 2.58e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755543021   703 LQRELSQLEAERQalrRDLETLQLTHKQLEGA-EEDRKALEQEVAQLEKDKKLLEKEARRL 762
Cdd:pfam09798    2 LRDKLELLQQEKE---KELEKLKNSYEELKSShEEELEKLKQEVQKLEDEKKFLLNELRSL 59
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
417-756 2.99e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.20  E-value: 2.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  417 YGELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEALKADR---ARQIKDLEQEKGHLHQAVWS 493
Cdd:COG4372    16 FGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARselEQLEEELEELNEQLQAAQAE 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  494 LRErpQVNSTKDVEKENRALHQAVTEAGSKLSQLELEKQQLHRDLEEAKEKGEQAealEKELHRLEKENEQLTKEVTSLK 573
Cdd:COG4372    96 LAQ--AQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAER---EEELKELEEQLESLQEELAALE 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  574 AATEKVEALEHQSQGLELENRSLRKSLDTLQNVSVQLEGLERDKQQLGQENLELRKMVEAMRFTSAKMAQIETENRQLER 653
Cdd:COG4372   171 QELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEE 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  654 EKEELRRDVELLKTLSKKSERLELSYQSVSAENLQLQHSLESSTHKSQALQRELSQLEAERQALRRDLETLQLTHKQLEG 733
Cdd:COG4372   251 LLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLEL 330

                         330       340
                  ....*....|....*....|...
gi 755543021  734 AEEDRKALEQEVAQLEKDKKLLE 756
Cdd:COG4372   331 ALAILLAELADLLQLLLVGLLDN 353
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
515-794 3.00e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 41.82  E-value: 3.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  515 QAVTEAGSKLSQLELEKQQLHRDLEEAKEKGEQAEALEKELHR-LEKENEQLTKEVTSLKAATEKVEALEHQSQGLELEN 593
Cdd:COG1340     1 SKTDELSSSLEELEEKIEELREEIEELKEKRDELNEELKELAEkRDELNAQVKELREEAQELREKRDELNEKVKELKEER 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  594 RSLRKSLDTLQNVSVQLEGLERDKQQLGQENLELRKMVEAMRFtsakmaQIETENRQLEREKEELRRDVELLKTLSKKSE 673
Cdd:COG1340    81 DELNEKLNELREELDELRKELAELNKAGGSIDKLRKEIERLEW------RQQTEVLSPEEEKELVEKIKELEKELEKAKK 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  674 RLEL--SYQSVSAENLQLQHSLESSTHKSQALQRELSQLEAERQALRRDLETLQlthKQLEGAEEDRKALEQEVAQLEKD 751
Cdd:COG1340   155 ALEKneKLKELRAELKELRKEAEEIHKKIKELAEEAQELHEEMIELYKEADELR---KEADELHKEIVEAQEKADELHEE 231

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 755543021  752 KKLLEKEARRLwqQVELKDAILDDSAAKLSAAEKESRALDKEL 794
Cdd:COG1340   232 IIELQKELREL--RKELKKLRKKQRALKREKEKEELEEKAEEI 272
Prefoldin_2 pfam01920
Prefoldin subunit; This family includes prefoldin subunits that are not detected by pfam02996.
 699-780 3.10e-03

Prefoldin subunit; This family includes prefoldin subunits that are not detected by pfam02996.


Pssm-ID: 396482 [Multi-domain]  Cd Length: 102  Bit Score: 39.13  E-value: 3.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   699 KSQALQRELSQLEAERQALRRDLETLQLTHKQLEGAEEDRK------------ALEQEVAQLEKDKKLLEKEARRLWQQV 766
Cdd:pfam01920    3 KFQQLQQQLQLLAQQIKQLETQLKELELALEELELLDEDTKvykligdvlvkqDKEEVKEQLEERKETLEKEIKTLEKQL 82

                           90
                   ....*....|....
gi 755543021   767 ELKDAILDDSAAKL 780
Cdd:pfam01920   83 EKLEKELEELKEEL 96
CCCAP pfam15964
Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in ...
 477-866 3.11e-03

Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in eukaryotes. CCCAP is also known as SDCCAG8, serologically defined colon cancer antigen 8. It is associated with the centrosome.


Pssm-ID: 435040 [Multi-domain]  Cd Length: 703  Bit Score: 42.59  E-value: 3.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   477 IKDLEQEKGHLHQAVWSLRErpqvnSTKDVEKENRALHQAVTEAGSKLSQLELEK-------QQLHRDLEEAKEKGEQAE 549
Cdd:pfam15964  302 IERLTKERDDLMSALVSVRS-----SLAEAQQRESSAYEQVKQAVQMTEEANFEKtkaliqcEQLKSELERQKERLEKEL 376

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   550 ALEKELHRLEKE--NEQLTKEVTSLKAA----TEKVEALEHQSQGLELENRSLRKSLDTLQNvsvqleglerdkqQLGQE 623
Cdd:pfam15964  377 ASQQEKRAQEKEalRKEMKKEREELGATmlalSQNVAQLEAQVEKVTREKNSLVSQLEEAQK-------------QLASQ 443

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   624 NLELRKMVEAMRF--TSAKMAQIETE----------NRQLEREKEELRRdveLLKTLSKKSERLELSYQSVS---AENLQ 688
Cdd:pfam15964  444 EMDVTKVCGEMRYqlNQTKMKKDEAEkehreyrtktGRQLEIKDQEIEK---LGLELSESKQRLEQAQQDAArarEECLK 520

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   689 L-------QHSLESSTHKSQALQRELSQlEAERQALRRDLETLQLTHKQLEGAEEDRKALEQEVAQLEKDKKLLEKEARR 761
Cdd:pfam15964  521 LtellgesEHQLHLTRLEKESIQQSFSN-EAKAQALQAQQREQELTQKMQQMEAQHDKTVNEQYSLLTSQNTFIAKLKEE 599

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   762 LWQQVELKDAILDDSAAKLSAAEKESRALDkelarcrdvgSKLKELEKDNRDLTKQVTMHTRTLTTLREDLvleklksQQ 841
Cdd:pfam15964  600 CCTLAKKLEEITQKSRSEVEQLSQEKEYLQ----------DRLEKLQKRNEELEEQCVQHGRMHERMKQRL-------RQ 662

                          410       420
                   ....*....|....*....|....*
gi 755543021   842 LSSELDKLSQELEKVGLSKDLLLQE 866
Cdd:pfam15964  663 LDKHCQATAQQLVQLLSKQNQLFKE 687
FPP pfam05911
Filament-like plant protein, long coiled-coil; FPP is a family of long coiled-coil plant ...
 356-484 3.14e-03

Filament-like plant protein, long coiled-coil; FPP is a family of long coiled-coil plant proteins that are filament-like. It interacts with the nuclear envelope-associated protein, MAF1, the WPP family pfam13943.


Pssm-ID: 461778 [Multi-domain]  Cd Length: 859  Bit Score: 42.74  E-value: 3.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   356 ELEQLSKNADLSDASRKSFVFELNEcassriLKLEKEN--QSLQSTIQGLRDTSLALEESSLKYGELEKENQQLSKKIEK 433
Cdd:pfam05911  668 DGPLVSGSNDLKTEENKRLKEEFEQ------LKSEKENleVELASCTENLESTKSQLQESEQLIAELRSELASLKESNSL 741

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 755543021   434 LQTQLEREKQSNQDLETLSEELIREKEQLQSGMEALKAdrarqikDLEQEK 484
Cdd:pfam05911  742 AETQLKCMAESYEDLETRLTELEAELNELRQKFEALEV-------ELEEEK 785
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 168-463 3.18e-03

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 42.52  E-value: 3.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  168 EDKQHLAVELADtKARLRRVRQELEEKTEQLADTRHEVDQLVLELQKAKQDNIQLAADARSAR-----------AYRDEL 236
Cdd:PRK04778   85 EEQLFEAEELND-KFRFRKAKHEINEIESLLDLIEEDIEQILEELQELLESEEKNREEVEQLKdlyrelrksllANRFSF 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  237 -DSLREKANRVERLEMDLVRCKEKLHDVDFYKARM--EELREDNI-----------ILIETKAMLEEQLTASRARSDK-- 300
Cdd:PRK04778  164 gPALDELEKQLENLEEEFSQFVELTESGDYVEAREilDQLEEELAaleqimeeipeLLKELQTELPDQLQELKAGYRElv 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  301 --------------VHELEKENLQLKSKLHDLELDRDADK-KQIEKLLEE-YMVLEM---AQKQSMKESAHLGWELEQLS 361
Cdd:PRK04778  244 eegyhldhldiekeIQDLKEQIDENLALLEELDLDEAEEKnEEIQERIDQlYDILERevkARKYVEKNSDTLPDFLEHAK 323

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  362 KNAD--LSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDtslALEESSLKYGELEKENQQLSKKIEKLQTQle 439
Cdd:PRK04778  324 EQNKelKEEIDRVKQSYTLNESELESVRQLEKQLESLEKQYDEITE---RIAEQEIAYSELQEELEEILKQLEEIEKE-- 398

                         330       340
                  ....*....|....*....|....
gi 755543021  440 rEKQSNQDLETLSEELIREKEQLQ 463
Cdd:PRK04778  399 -QEKLSEMLQGLRKDELEAREKLE 421
CHASE3 COG5278
Extracytoplasmic sensor domain CHASE3 (specificity unknown) [Signal transduction mechanisms];
196-654 3.20e-03

Extracytoplasmic sensor domain CHASE3 (specificity unknown) [Signal transduction mechanisms];


Pssm-ID: 444089 [Multi-domain]  Cd Length: 530  Bit Score: 42.20  E-value: 3.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  196 EQLADTRHEVDQLVLELQKAKQDNIQLAADARSARA-YRDELDSLREKANRVERLEMDLVRckeKLHDVDFYKARMEELR 274
Cdd:COG5278    79 EPYEEARAEIDELLAELRSLTADNPEQQARLDELEAlIDQWLAELEQVIALRRAGGLEAAL---ALVRSGEGKALMDEIR 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  275 EDNIILIETKAMLEEQLTASRARSDKVHELEKENLQLksklhDLELDRDADKKQIEKLLEEYMVLEMAQKQSMKESAHLG 354
Cdd:COG5278   156 ARLLLLALALAALLLAAAALLLLLLALAALLALAELL-----LLALARALAALLLLLLLEAELAAAAALLAAAAALAALA 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  355 WELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDTSLALEESSLKYGELEKENQQLSKKIEKL 434
Cdd:COG5278   231 ALELLAALALALALLLAALLLALLAALALAALLAAALLALAALLLALAAAAALAAAAALELAAAEALALAELELELLLAA 310

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  435 QTQLEREKQSNQDLETLSEELIREKEQLQSGMEALKADRARQIKDLEQEKGHLHQAVWSLRERPQVNSTKDVEKENRALH 514
Cdd:COG5278   311 AAAAAAAAAAAAAALAALLALALATALAAAAAALALLAALLAEAAAAAAEEAEAAAEAAAAALAGLAEVEAEGAAEAVEL 390

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  515 QAVTEAGSKLSQLELEKQQLHRDLEEAKEKGEQAEALEKELHRLEKENEQLTKEVTSLKAATEKVEALEHQSQGLELENR 594
Cdd:COG5278   391 EVLAIAAAAAAAAAEAAAAAAAAAAASAAEALELAEALAEALALAEEEALALAAASSELAEAGAALALAAAEALAEELAA 470

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  595 SLRKSLDTLQNVSVQLEGLERDKQQLGQENLELRKMVEAMRFTSAKMAQIETENRQLERE 654
Cdd:COG5278   471 VAALAALAAAAAALAEAEAAAALAAAAALSLALALAALLLAAAEAALAAALAAALASAEL 530
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
589-856 3.39e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 42.31  E-value: 3.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  589 LELENRSLRKSLDTLQNVSVQLEGLERDKQQLGQENLeLRKMVEAMRFTSAKMAQIETENRQLERekeeLRRDVELlkTL 668
Cdd:COG3206    59 LLVEPQSSDVLLSGLSSLSASDSPLETQIEILKSRPV-LERVVDKLNLDEDPLGEEASREAAIER----LRKNLTV--EP 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  669 SKKSERLELSYQSVSAE--------------NLQLQHSLESSTHKSQALQRELSQLEAERQALRRDLETLQLTHK----- 729
Cdd:COG3206   132 VKGSNVIEISYTSPDPElaaavanalaeaylEQNLELRREEARKALEFLEEQLPELRKELEEAEAALEEFRQKNGlvdls 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  730 ---------------QLEGAEEDRKALEQEVAQLEKDKKLLEKEARRLwqqveLKDAILDDSAAKLSAAEKEsraLDKEL 794
Cdd:COG3206   212 eeaklllqqlselesQLAEARAELAEAEARLAALRAQLGSGPDALPEL-----LQSPVIQQLRAQLAELEAE---LAELS 283

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755543021  795 ARCRDVGSKLKELEKDNRDLTKQV-TMHTRTLTTLREDLVLEKLKSQQLSSELDKLSQELEKV 856
Cdd:COG3206   284 ARYTPNHPDVIALRAQIAALRAQLqQEAQRILASLEAELEALQAREASLQAQLAQLEARLAEL 346
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1127-1305 3.45e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 42.06  E-value: 3.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1127 DLQQRKAELEELEKVLSTEREALEREQKTNAIATSENQRLRGELDRISFLHQQLKGEYEELHAHTKELKTSLNNSQLELS 1206
Cdd:COG4942    21 AAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELE 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1207 RWQVRFDELKEQHQSMDI-----------SLTKMDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQmLLEQNMESKEQY 1275
Cdd:COG4942   101 AQKEELAELLRALYRLGRqpplalllspeDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRA-ELEAERAELEAL 179

                         170       180       190
                  ....*....|....*....|....*....|
gi 755543021 1276 HEEQKQYIDKLNALRRHKEKLEEKIMDQYK 1305
Cdd:COG4942   180 LAELEEERAALEALKAERQKLLARLEKELA 209
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 895-1198 3.46e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 42.19  E-value: 3.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   895 LEAQVEEKESLSRQLQIELQMIKKEHEQLRQTQEGGDKAQNALKRPPGKVTSHQE------KEAWEPSHK------EATM 962
Cdd:pfam07888   71 WERQRRELESRVAELKEELRQSREKHEELEEKYKELSASSEELSEEKDALLAQRAaheariRELEEDIKTltqrvlERET 150

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   963 ELLRVKDRAIELERSNAALQAERQLLKEQLQHLETQNVSFSSQILTLQKQSAFLQEHTTTLQTQTAKLQVENSTL---SS 1039
Cdd:pfam07888  151 ELERMKERAKKAGAQRKEEEAERKQLQAKLQQTEEELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTAhrkEA 230

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1040 QNAALSAQYTVLQSQQAAKEAEHEGLQQQQEQLAA--------VYEALLQDHKHLGTLYECQSSEYEALIRQHSCLKTLH 1111
Cdd:pfam07888  231 ENEALLEELRSLQERLNASERKVEGLGEELSSMAAqrdrtqaeLHQARLQAAQLTLQLADASLALREGRARWAQERETLQ 310

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1112 RNLELEHKELGERHGDLQQRKAELEELEkvlsTEREALE----REQKTNAIATSENQR----LRGELDRISFLHQQLKGE 1183
Cdd:pfam07888  311 QSAEADKDRIEKLSAELQRLEERLQEER----MEREKLEvelgREKDCNRVQLSESRRelqeLKASLRVAQKEKEQLQAE 386

                          330
                   ....*....|....*
gi 755543021  1184 YEELHAHTKELKTSL 1198
Cdd:pfam07888  387 KQELLEYIRQLEQRL 401
PRK01156 PRK01156
chromosome segregation protein; Provisional
 522-1006 3.46e-03

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 42.58  E-value: 3.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  522 SKLSQLELEKQQLHRDLEEAKEKGEQAEA----LEKELHRLEKENEQLTKEVTSLKAATEKVEALEHQSQGLELENRSLR 597
Cdd:PRK01156  183 SNIDYLEEKLKSSNLELENIKKQIADDEKshsiTLKEIERLSIEYNNAMDDYNNLKSALNELSSLEDMKNRYESEIKTAE 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  598 KSLDTLQNVSVQLEGLE----------------------RDKQQLGQ-----ENL--ELRKMVEAMRftsaKMAQIETEN 648
Cdd:PRK01156  263 SDLSMELEKNNYYKELEerhmkiindpvyknrnyindyfKYKNDIENkkqilSNIdaEINKYHAIIK----KLSVLQKDY 338

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  649 RQLE---REKEELRRDVELLKT--------------LSKKSERLELSYQSVSAENLQ-----------LQHSLESSTHKS 700
Cdd:PRK01156  339 NDYIkkkSRYDDLNNQILELEGyemdynsylksiesLKKKIEEYSKNIERMSAFISEilkiqeidpdaIKKELNEINVKL 418

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  701 QALQRELSQLEAERQALRRDLETLQLTHKQLEGA----------------------EEDRKALEQEVAQLEKDKKLLEKE 758
Cdd:PRK01156  419 QDISSKVSSLNQRIRALRENLDELSRNMEMLNGQsvcpvcgttlgeeksnhiinhyNEKKSRLEEKIREIEIEVKDIDEK 498

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  759 ARrlwQQVELKDAILDDSAAKLSAAEKESRALDKELARCRDVGSKLKELEKDNRDLTKQV-TMHTRTLTTLREDLVleKL 837
Cdd:PRK01156  499 IV---DLKKRKEYLESEEINKSINEYNKIESARADLEDIKIKINELKDKHDKYEEIKNRYkSLKLEDLDSKRTSWL--NA 573

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  838 KSQQLSSELDKL-SQELEKVGLSKDLL--LQE-DDGHGDGKGKTESALKttlamkeekivfleaQVEEKESLSRQLQIEL 913
Cdd:PRK01156  574 LAVISLIDIETNrSRSNEIKKQLNDLEsrLQEiEIGFPDDKSYIDKSIR---------------EIENEANNLNNKYNEI 638

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  914 QMIKKEHEQLRQTQEGGdKAQNAlkrppgkvtshqEKEAWEPSHKEATMELLRVKDRAIELERSNAALQAERQLLKEQLQ 993
Cdd:PRK01156  639 QENKILIEKLRGKIDNY-KKQIA------------EIDSIIPDLKEITSRINDIEDNLKKSRKALDDAKANRARLESTIE 705

                         570
                  ....*....|...
gi 755543021  994 HLETQNVSFSSQI 1006
Cdd:PRK01156  706 ILRTRINELSDRI 718
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 735-1061 3.75e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.42  E-value: 3.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   735 EEDRKALEQEVAQLEKDKKLLEKEARRLWQQVE-LKDAILDDSAAKLSAAEKESRALDKELARCRDVGSKlKELEKDNRD 813
Cdd:pfam17380  290 QEKFEKMEQERLRQEKEEKAREVERRRKLEEAEkARQAEMDRQAAIYAEQERMAMERERELERIRQEERK-RELERIRQE 368

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   814 ltkQVTMHtrtLTTLREdlvLEKLKSQQLSSElDKLSQELEKVGLSKDLLLQEDDGHGDGKGKTESALKTTLAMKEEKIV 893
Cdd:pfam17380  369 ---EIAME---ISRMRE---LERLQMERQQKN-ERVRQELEAARKVKILEEERQRKIQQQKVEMEQIRAEQEEARQREVR 438

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   894 FLEaqvEEKESLSRQLQIELQMIKKEHEQLRQTQEGGDKAQNALKRppgkvTSHQEKEAWEPSHKEATMELLRVKDRAIE 973
Cdd:pfam17380  439 RLE---EERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELEK-----EKRDRKRAEEQRRKILEKELEERKQAMIE 510

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   974 LERsnaalqaERQLLKEQLQhlETQNVSFSSQ---ILTLQKQSAFLQEHTTTLQTQTAKLQVENSTLSSQNAALSAQYTV 1050
Cdd:pfam17380  511 EER-------KRKLLEKEME--ERQKAIYEEErrrEAEEERRKQQEMEERRRIQEQMRKATEERSRLEAMEREREMMRQI 581

                          330
                   ....*....|.
gi 755543021  1051 LQSQQAAKEAE 1061
Cdd:pfam17380  582 VESEKARAEYE 592
PRK09039 PRK09039
peptidoglycan -binding protein;
684-809 3.80e-03

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 41.88  E-value: 3.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  684 AENLQLQHSLEssthksqALQRELSQLEAERQALRRDLETLQlthKQLEGAEEDRKALEQEVAQLEKdkklLEKEARR-- 761
Cdd:PRK09039   74 QGNQDLQDSVA-------NLRASLSAAEAERSRLQALLAELA---GAGAAAEGRAGELAQELDSEKQ----VSARALAqv 139

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 755543021  762 --LWQQVELKDAILDDSAAKLSAAEKESRALDKELArcrDVGSKL--------KELEK 809
Cdd:PRK09039  140 elLNQQIAALRRQLAALEAALDASEKRDRESQAKIA---DLGRRLnvalaqrvQELNR 194
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
 174-562 4.08e-03

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 42.15  E-value: 4.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   174 AVELADtKARLRRVRQELEEKTEQLADTRHEVDQLvlelqkakqdniqlaadarsarayRDELDSLREKANRVeRLEMDl 253
Cdd:pfam06160   72 AEELND-KYRFKKAKKALDEIEELLDDIEEDIKQI------------------------LEELDELLESEEKN-REEVE- 124

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   254 vRCKEKlhdvdfYKARMEELREDNIILIETKAMLEEQLTASRARSDKVHEL---------EKENLQLKSKLHDLEldrdA 324
Cdd:pfam06160  125 -ELKDK------YRELRKTLLANRFSYGPAIDELEKQLAEIEEEFSQFEELtesgdyleaREVLEKLEEETDALE----E 193

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   325 DKKQIEKLLEEYMVLEMAQkqsmkesahlgweLEQLSKNADlsDASRKSFVFELNEcASSRILKLEKENQSLQSTIqglr 404
Cdd:pfam06160  194 LMEDIPPLYEELKTELPDQ-------------LEELKEGYR--EMEEEGYALEHLN-VDKEIQQLEEQLEENLALL---- 253

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   405 dtslaleeSSLKYGELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEALKAD------------ 472
Cdd:pfam06160  254 --------ENLELDEAEEALEEIEERIDQLYDLLEKEVDAKKYVEKNLPEIEDYLEHAEEQNKELKEElervqqsytlne 325

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   473 ----RARQI-KDLEQEKGHLHQAVWSLRERPQVNStkDVEKENRALHQAVTEAGSKLSQLELEKQQLHRDLEEAKEKGEQ 547
Cdd:pfam06160  326 neleRVRGLeKQLEELEKRYDEIVERLEEKEVAYS--ELQEELEEILEQLEEIEEEQEEFKESLQSLRKDELEAREKLDE 403

                          410
                   ....*....|....*....
gi 755543021   548 aeaLEKELH----RLEKEN 562
Cdd:pfam06160  404 ---FKLELReikrLVEKSN 419
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
610-758 4.45e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 41.77  E-value: 4.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  610 LEGLERDKQqlgqeNLELRKMVEAMRFTSAKMAQIETENRQLEREKEELRRDVELLK-TLSKKSERLElsyqsvsaeNLQ 688
Cdd:COG2433   382 LEELIEKEL-----PEEEPEAEREKEHEERELTEEEEEIRRLEEQVERLEAEVEELEaELEEKDERIE---------RLE 447

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755543021  689 LQHSLESSTHKSQAL-QRELSQLEAERQALRRDLETLqlthkqlegaEEDRKALEQEVAQLEKDKKLLEKE 758
Cdd:COG2433   448 RELSEARSEERREIRkDREISRLDREIERLERELEEE----------RERIEELKRKLERLKELWKLEHSG 508
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 1712-1916 4.52e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.90  E-value: 4.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1712 ASLSRAFSLASADLLRASGPEACRPESPQKPGGHEAAGARETSTHSLQGSHILARERTP---IVGKADSPSPGQGTRGRP 1788
Cdd:PRK07764  591 APGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAApehHPKHVAVPDASDGGDGWP 670

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021 1789 LDTRRFSLAPPkeerlaplqQSATAPALATGCSSGSNPQIQHFSPTVAPAVRTKSKVPQHSGEVATVAPVRPglgtSEGD 1868
Cdd:PRK07764  671 AKAGGAAPAAP---------PPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSP----AADD 737

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 755543021 1869 GGPGHGYSEgLLTKSPGRSSDLPPHVKRGPDDFSQGSSSKSTPASPEP 1916
Cdd:PRK07764  738 PVPLPPEPD-DPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEE 784
hsdR PRK11448
type I restriction enzyme EcoKI subunit R; Provisional
 664-771 4.64e-03

type I restriction enzyme EcoKI subunit R; Provisional


Pssm-ID: 236912 [Multi-domain]  Cd Length: 1123  Bit Score: 42.25  E-value: 4.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  664 LLKTLSKKSERLELSYQSVSAENLQLQHSLESSTHKSQALQRELSQLEAERQALRRDLEtlQLTHKQLEGAEEDRKALEQ 743
Cdd:PRK11448  143 LLHALQQEVLTLKQQLELQAREKAQSQALAEAQQQELVALEGLAAELEEKQQELEAQLE--QLQEKAAETSQERKQKRKE 220

                          90       100
                  ....*....|....*....|....*...
gi 755543021  744 EVAQLEKDKKLLEKEARRLWQQvELKDA 771
Cdd:PRK11448  221 ITDQAAKRLELSEEETRILIDQ-QLRKA 247
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 533-855 5.11e-03

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 41.87  E-value: 5.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  533 QLHRDLEEAKEKGEQAEALEKELHrlEKENEQLTKEVTSLKAATEKVEALEHQSQGLELEnrSLRKSLDTLQNVSVQLEG 612
Cdd:COG5185   211 ETGNLGSESTLLEKAKEIINIEEA--LKGFQDPESELEDLAQTSDKLEKLVEQNTDLRLE--KLGENAESSKRLNENANN 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  613 LERDKQQLGQENLELRKMVEAMRFTSAKMAQIET--ENRQLEREKEELRRDVELLKT-LSKKSERLELSYQSVSAENLQL 689
Cdd:COG5185   287 LIKQFENTKEKIAEYTKSIDIKKATESLEEQLAAaeAEQELEESKRETETGIQNLTAeIEQGQESLTENLEAIKEEIENI 366

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  690 QHSLESSThksqaLQRELSQLEAERQALRRDLETLqltHKQLEGAEEDrkaleqEVAQLEKDKKLLEKEARRLWQQVElk 769
Cdd:COG5185   367 VGEVELSK-----SSEELDSFKDTIESTKESLDEI---PQNQRGYAQE------ILATLEDTLKAADRQIEELQRQIE-- 430

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  770 daildDSAAKLSAAEKESRALDKELARCRDvgsklKELEKDNRDLTKQVTMHTRTLTTLREDLvleKLKSQQLSSELDKL 849
Cdd:COG5185   431 -----QATSSNEEVSKLLNELISELNKVMR-----EADEESQSRLEEAYDEINRSVRSKKEDL---NEELTQIESRVSTL 497


                  ....*.
gi 755543021  850 SQELEK 855
Cdd:COG5185   498 KATLEK 503
FtsB COG2919
Cell division protein FtsB [Cell cycle control, cell division, chromosome partitioning];
713-761 5.13e-03

Cell division protein FtsB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442163 [Multi-domain]  Cd Length: 96  Bit Score: 38.32  E-value: 5.13e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 755543021  713 ERQALRRDLETLQlthKQLEGAEEDRKALEQEVAQLEKDKKLLEKEARR 761
Cdd:COG2919    30 AYRELRQEIAELE---AENAKLKARNAELEAEVADLKDGPDYIEERARE 75
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 575-789 5.19e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 41.35  E-value: 5.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  575 ATEKVEALEHQSQGLELENRSLRKSLDTLQNvsvQLEGLERDKQQLGQENLELRKMVEAMRftsakmAQIETENRQLERE 654
Cdd:COG3883    14 ADPQIQAKQKELSELQAELEAAQAELDALQA---ELEELNEEYNELQAELEALQAEIDKLQ------AEIAEAEAEIEER 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  655 KEELRRDVELLKTLSKKSERLEL------------SYQSVSAENLQLQHSLESSTHKSQALQRELSQLEAERQALRRDLE 722
Cdd:COG3883    85 REELGERARALYRSGGSVSYLDVllgsesfsdfldRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKA 164

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755543021  723 TLQLTHKQLEGAEEDRKA----LEQEVAQLEKDKKLLEKEARRLWQQVELKDAILDDSAAKLSAAEKESRA 789
Cdd:COG3883   165 ELEAAKAELEAQQAEQEAllaqLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAA 235
TMCO5 pfam14992
TMCO5 family; The TMCO5 family includes human transmembrane and coiled-coil domain-containing ...
 613-811 5.98e-03

TMCO5 family; The TMCO5 family includes human transmembrane and coiled-coil domain-containing proteins 5A and 5B.


Pssm-ID: 464427 [Multi-domain]  Cd Length: 278  Bit Score: 40.86  E-value: 5.98e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   613 LERDKQQLGQENLE-LRKMVE---AMRFTSAKMAQIETENRQLEREKEE--LRRDVELLKTLSKKSERLELSYQSVSAEN 686
Cdd:pfam14992    8 LEKDLQRLDEANQVlLLKIQEkeeEIQSLEREITLTRSLAEDEEREELNftIMEKEDALQELELETAKLEKKNEILVKSV 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   687 LQLQHSLESSTHKSQALQRE-LSQLEAERQA-LRRDLETLQLTHKQLEGAEEDRkaleQEVAQLEKDKKLLEKEARRLWQ 764
Cdd:pfam14992   88 MELQRKLSRKSDKNTGLEQEtLKQMLEELKVkLQQSEESCADQEKELAKVESDY----QSVHQLCEDQALCIKKYQEILR 163

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 755543021   765 QVElkdailddsaaklsaAEKESRALDKELARCRDVGSKLKELEKDN 811
Cdd:pfam14992  164 KME---------------EEKETRLLEKEVSKAQSNSSQRVKLVETI 195
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 719-1299 6.07e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 41.70  E-value: 6.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   719 RDLETLQLTHKQLEGAEEDRKALEQEVAQLEKDKKLLEKEARRLWQQVELKDAILDDSA---AKLSAAEKESRALDKELA 795
Cdd:pfam01576    2 RQEEEMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQAETELCAEAEemrARLAARKQELEEILHELE 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   796 rcrdvgSKLKELEKDNRDLTKQVTMHTRTLTTLREDLVLEKLKSQQLssELDKLSQELEKVGLSKDLLLQEDDGHGDGKG 875
Cdd:pfam01576   82 ------SRLEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKL--QLEKVTTEAKIKKLEEDILLLEDQNSKLSKE 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   876 KTE-----SALKTTLAMKEEKIVFLEAQVEEKESLSRQLQIELqmikKEHEQLRQTQEggdkaqNALKRPPGKVTSHQEK 950
Cdd:pfam01576  154 RKLleeriSEFTSNLAEEEEKAKSLSKLKNKHEAMISDLEERL----KKEEKGRQELE------KAKRKLEGESTDLQEQ 223

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   951 EAwepshkeatmellRVKDRAIELERSNAALQAERQLLKEQLQHLETQNVSFSSQILTLQKQSAFLQEHTTTLQTQTAKL 1030
Cdd:pfam01576  224 IA-------------ELQAQIAELRAQLAKKEEELQAALARLEEETAQKNNALKKIRELEAQISELQEDLESERAARNKA 290

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1031 QVENSTLSSQNAALSAQY-------TVLQSQQAAKEAEHEGLQQQQEQLAAVYEALLQD--HKHLGTLYECQsSEYEALI 1101
Cdd:pfam01576  291 EKQRRDLGEELEALKTELedtldttAAQQELRSKREQEVTELKKALEEETRSHEAQLQEmrQKHTQALEELT-EQLEQAK 369

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1102 RQHSCLKTLHRNLELEHKELGERHGDLQQRKAELEELEKVL------------STEREALEREQKTnaiatsenQRLRGE 1169
Cdd:pfam01576  370 RNKANLEKAKQALESENAELQAELRTLQQAKQDSEHKRKKLegqlqelqarlsESERQRAELAEKL--------SKLQSE 441

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  1170 LDRISFLHQQLKGEYEELHAHTKELKTSLNNSQLELSrwqvrfdelKEQHQSMDISlTKMDNHCELLSRLKGNLEEE--- 1246
Cdd:pfam01576  442 LESVSSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQ---------EETRQKLNLS-TRLRQLEDERNSLQEQLEEEeea 511

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 755543021  1247 NHHLLSQIQLLSQQNQML---LEQNMESKEQYHEEQKQYIDKLNALRrhkEKLEEK 1299
Cdd:pfam01576  512 KRNVERQLSTLQAQLSDMkkkLEEDAGTLEALEEGKKRLQRELEALT---QQLEEK 564
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 411-679 6.60e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 41.45  E-value: 6.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  411 EESSLKYGELEKENQQLSKKIEKLQTQLEREKqsnqdleTLSEELIREKEQlqsGMEALkadrarqIKDLEQEKGhlhqa 490
Cdd:PRK05771   39 ELSNERLRKLRSLLTKLSEALDKLRSYLPKLN-------PLREEKKKVSVK---SLEEL-------IKDVEEELE----- 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  491 vwslrerpqvnstkDVEKENRALHQAVTEAGSKLSQLELEKQQLhrdleeakekgEQAEALEKELHRLekeneqLTKEVT 570
Cdd:PRK05771   97 --------------KIEKEIKELEEEISELENEIKELEQEIERL-----------EPWGNFDLDLSLL------LGFKYV 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  571 SLKAAT---EKVEALEHQSQGLELENRSLRKSLDT--LQNVSVQLEGLERDKQQLGQENLELRKMVEAmrftSAKMAQIE 645
Cdd:PRK05771  146 SVFVGTvpeDKLEELKLESDVENVEYISTDKGYVYvvVVVLKELSDEVEEELKKLGFERLELEEEGTP----SELIREIK 221

                         250       260       270
                  ....*....|....*....|....*....|....
gi 755543021  646 TENRQLEREKEELRRDvelLKTLSKKSERLELSY 679
Cdd:PRK05771  222 EELEEIEKERESLLEE---LKELAKKYLEELLAL 252
PRK12704 PRK12704
phosphodiesterase; Provisional
 368-483 6.69e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 41.30  E-value: 6.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  368 DASRKSFVFELNECASSRILKLEKENQSLQSTIQGLrDTSLALEESSL--KYGELEKENQQLSKKIEKLQTQLEREKQSN 445
Cdd:PRK12704   52 EAIKKEALLEAKEEIHKLRNEFEKELRERRNELQKL-EKRLLQKEENLdrKLELLEKREEELEKKEKELEQKQQELEKKE 130

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 755543021  446 QDLETLSEELIRE------------KEQLQSGMEA-LKADRARQIKDLEQE 483
Cdd:PRK12704  131 EELEELIEEQLQElerisgltaeeaKEILLEKVEEeARHEAAVLIKEIEEE 181
46 PHA02562
endonuclease subunit; Provisional
 464-751 6.72e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 41.15  E-value: 6.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  464 SGMEALKADRAR----QIKDLEQEKGHLHQavwslrerpQVNSTKDVEKENRALH-QAVTEAGSKLSQLelekqqlhrdL 538
Cdd:PHA02562  166 SEMDKLNKDKIRelnqQIQTLDMKIDHIQQ---------QIKTYNKNIEEQRKKNgENIARKQNKYDEL----------V 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  539 EEAKEKGEQAEALEKELHRLEKENEQLTKEVTSLKAATEKVEAlehqsqglelenrslrkSLDTLQNVSVQLEglERD-- 616
Cdd:PHA02562  227 EEAKTIKAEIEELTDELLNLVMDIEDPSAALNKLNTAAAKIKS-----------------KIEQFQKVIKMYE--KGGvc 287

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  617 ---KQQLGQENlelrKMVEAMRftsAKMAQIETENRQLEREKEELRRDVELLKTLSKKSERLELSYQsvsaenlQLQHSL 693
Cdd:PHA02562  288 ptcTQQISEGP----DRITKIK---DKLKELQHSLEKLDTAIDELEEIMDEFNEQSKKLLELKNKIS-------TNKQSL 353

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755543021  694 ESSTHKSQALQRELSQLEAERQALRRDLETLQlthKQLEGAEEDRKALEQE------VAQLEKD 751
Cdd:PHA02562  354 ITLVDKAKKVKAAIEELQAEFVDNAEELAKLQ---DELDKIVKTKSELVKEkyhrgiVTDLLKD 414
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
 539-721 6.76e-03

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 39.89  E-value: 6.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   539 EEAKEKGEQAEALEKELHRLEKENEQLTKEvtsLKAATEKVEALEHQSQGLELENRSlrksldtLQNVSVQLEGLERDKQ 618
Cdd:pfam13851   33 EEIAELKKKEERNEKLMSEIQQENKRLTEP---LQKAQEEVEELRKQLENYEKDKQS-------LKNLKARLKVLEKELK 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   619 QLGQENLELRkmveaMRFTsakmaqietenrQLEREKEEL-RRDVELLKTLSKKSE--------RLELSYQSVSAENLQL 689
Cdd:pfam13851  103 DLKWEHEVLE-----QRFE------------KVERERDELyDKFEAAIQDVQQKTGlknlllekKLQALGETLEKKEAQL 165

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 755543021   690 QHSLESS---THKSQALQRELSQLEAERQALRRDL 721
Cdd:pfam13851  166 NEVLAAAnldPDALQAVTEKLEDVLESKNQLIKDL 200
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 176-336 7.18e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 40.29  E-value: 7.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  176 ELADTKARLRRVRQELEEKTEQLADTRHEVDQLVLELQKAK------QDNIQLAADARSARAYRDELDSLREkanRVERL 249
Cdd:COG1579    32 ELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEarikkyEEQLGNVRNNKEYEALQKEIESLKR---RISDL 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  250 EMDLVRCKEKLHDVDFYKARMEELREDniilietkamLEEQLTASRArsdkvhELEKENLQLKSKLHDLELDRDADKKQI 329
Cdd:COG1579   109 EDEILELMERIEELEEELAELEAELAE----------LEAELEEKKA------ELDEELAELEAELEELEAEREELAAKI 172


                  ....*...
gi 755543021  330 EK-LLEEY 336
Cdd:COG1579   173 PPeLLALY 180
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
117-297 7.41e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 41.44  E-value: 7.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  117 LRRLIDERDECTELIVDLTQERDYLQTQQPpspgkfsspDSTPSPTSSLSSEDKQHLAVELADTKARLRRVRQ---ELEE 193
Cdd:COG4913   619 LAELEEELAEAEERLEALEAELDALQERRE---------ALQRLAEYSWDEIDVASAEREIAELEAELERLDAssdDLAA 689

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  194 KTEQLADTRHEVDQLVLELQKAKQDNIQLAADARSARAYRDELDSLREKANRVERLEMDLvRCKEKLHDVDFYKAR---M 270
Cdd:COG4913   690 LEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRA-LLEERFAAALGDAVErelR 768

                         170       180
                  ....*....|....*....|....*..
gi 755543021  271 EELREDNIILIETKAMLEEQLTASRAR 297
Cdd:COG4913   769 ENLEERIDALRARLNRAEEELERAMRA 795
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 169-293 7.58e-03

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 41.22  E-value: 7.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  169 DKqhlAVELADTKARlrRVRQELEEKTEQLADTRHEVDQLVLELQKAKQDniQLAADARSARAYRDELDSLREKAnrvER 248
Cdd:COG0542   389 DK---AIDLIDEAAA--RVRMEIDSKPEELDELERRLEQLEIEKEALKKE--QDEASFERLAELRDELAELEEEL---EA 458

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 755543021  249 LEMDLVRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTA 293
Cdd:COG0542   459 LKARWEAEKELIEEIQELKEELEQRYGKIPELEKELAELEEELAE 503
ZapB COG3074
Cell division protein ZapB, interacts with FtsZ [Cell cycle control, cell division, chromosome ...
 419-475 7.60e-03

Cell division protein ZapB, interacts with FtsZ [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442308 [Multi-domain]  Cd Length: 79  Bit Score: 37.26  E-value: 7.60e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 755543021  419 ELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEALKADRAR 475
Cdd:COG3074     8 ELEAKVQQAVDTIELLQMEVEELKEKNEELEQENEELQSENEELQSENEQLKTENAE 64
COG4026 COG4026
Uncharacterized conserved protein, contains TOPRIM domain, potential nuclease [General ...
 506-603 7.74e-03

Uncharacterized conserved protein, contains TOPRIM domain, potential nuclease [General function prediction only];


Pssm-ID: 443204 [Multi-domain]  Cd Length: 287  Bit Score: 40.48  E-value: 7.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  506 VEKEnraLHQAVTEAGSKLSQLELEKQQLHRDLEEAKEK----GEQAEALEKELHRLEKENEQLTKEVTSLKaatEKVEA 581
Cdd:COG4026   108 VRKE---IKNAIIRAGLKSLQNIPEYNELREELLELKEKideiAKEKEKLTKENEELESELEELREEYKKLR---EENSI 181

                          90       100
                  ....*....|....*....|..
gi 755543021  582 LEHQSQGLELENRSLRKSLDTL 603
Cdd:COG4026   182 LEEEFDNIKSEYSDLKSRFEEL 203
Jnk-SapK_ap_N pfam09744
JNK_SAPK-associated protein-1; This is the N-terminal 200 residues of a set of proteins ...
 410-519 7.87e-03

JNK_SAPK-associated protein-1; This is the N-terminal 200 residues of a set of proteins conserved from yeasts to humans. Most of the proteins in this entry have an RhoGEF pfam00621 domain at their C-terminal end.


Pssm-ID: 462875 [Multi-domain]  Cd Length: 150  Bit Score: 38.75  E-value: 7.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   410 LEESSLKYGELEKENQQLSKKIEKLQTQLEREKQ----SNQDLETLSEELIREKEQLQSGMEALKadraRQIKDLEQEKg 485
Cdd:pfam09744   38 LESLASRNQEHNVELEELREDNEQLETQYEREKAlrkrAEEELEEIEDQWEQETKDLLSQVESLE----EENRRLEADH- 112

                           90       100       110
                   ....*....|....*....|....*....|....
gi 755543021   486 hlhqaVWSLRERPQvnstkDVEKENRALHQAVTE 519
Cdd:pfam09744  113 -----VSRLEEKEA-----ELKKEYSKLHERETE 136
AAA_13 pfam13166
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ...
 353-774 8.00e-03

AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. This family includes the PrrC protein that is thought to be the active component of the anticodon nuclease.


Pssm-ID: 463796 [Multi-domain]  Cd Length: 712  Bit Score: 41.20  E-value: 8.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   353 LGWELEQLSKNADLSDASRKSFVFELNECASSRILKLE--KENQSLQSTIQGLrdtslaleessLKYGELEKENQqlsKK 430
Cdd:pfam13166   32 LSRLLRSLELGEPHPKFANGKFEWTNGQPLDIRVFNRDfvEENLSEQGEIKPI-----------FTLGEESIEIQ---EK 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   431 IEKLQTQLerekqsnQDLETLSEELIREKEQLQSGMEALKADRARQIKDLEQEKGH--LHQAVWSLR--ERPQVNSTKDV 506
Cdd:pfam13166   98 IAKLKKEI-------KDHEEKLDAAEANLQKLDKEKEKLEADFLDECWKKIKRKKNsaLSEALNGFKyeANFKSRLLREI 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   507 EKENRAlhqavteAGSKLSQlELEKQQLHRDLEEAKEKGEQAEALEKELHRLEKENEQLTKEVTSLKAATEKVEALEHQS 586
Cdd:pfam13166  171 EKDNFN-------AGVLLSD-EDRKAALATVFSDNKPEIAPLTFNVIDFDALEKAEILIQKVIGKSSAIEELIKNPDLAD 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   587 ---QGLELEN--------------RSLRKSLDT---------LQNVSVQLEGLERDKQQLGQenlELRKMVEAMRFTSA- 639
Cdd:pfam13166  243 wveQGLELHKahldtcpfcgqplpAERKAALEAhfddeftefQNRLQKLIEKVESAISSLLA---QLPAVSDLASLLSAf 319

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   640 --KMAQIETENRQLEREKEELRRDVEllktlSKKSERLELSYQSVSAENLQLQHSLESSTHKSQALQRELSQ-LEAERQA 716
Cdd:pfam13166  320 elDVEDIESEAEVLNSQLDGLRRALE-----AKRKDPFKSIELDSVDAKIESINDLVASINELIAKHNEITDnFEEEKNK 394

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755543021   717 LRRDLE--TLQLTHKQLEGAEEDRKALEQEVAQLEKDKKLLEKEARRLWQQV-ELKDAILD 774
Cdd:pfam13166  395 AKKKLRlhLVEEFKSEIDEYKDKYAGLEKAINSLEKEIKNLEAEIKKLREEIkELEAQLRD 455
TPR_MLP1_2 pfam07926
TPR/MLP1/MLP2-like protein; The sequences featured in this family are similar to a region of ...
 638-768 8.05e-03

TPR/MLP1/MLP2-like protein; The sequences featured in this family are similar to a region of human TPR protein and to yeast myosin-like proteins 1 (MLP1) and 2 (MLP2). These proteins share a number of features; for example, they all have coiled-coil regions and all three are associated with nuclear pores. TPR is thought to be a component of nuclear pore complex- attached intra-nuclear filaments, and is implicated in nuclear protein import. Moreover, its N-terminal region is involved in the activation of oncogenic kinases, possibly by mediating the dimerization of kinase domains or by targeting these kinases to the nuclear pore complex. MLP1 and MLP2 are involved in the process of telomere length regulation, where they are thought to interact with proteins such as Tel1p and modulate their activity.


Pssm-ID: 462316 [Multi-domain]  Cd Length: 129  Bit Score: 38.39  E-value: 8.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   638 SAKMAQIETENRQLEREKEELRRDVELLKTLSKKSERlELSYQSVSAENLQlqhslessthksqALQRELSQLEAERQAL 717
Cdd:pfam07926   11 KRLKEEAADAEAQLQKLQEDLEKQAEIAREAQQNYER-ELVLHAEDIKALQ-------------ALREELNELKAEIAEL 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 755543021   718 RRDLETLQLTHKQLEGA-EEDRKALEQEVAQLEKDKKLLEKEARRLWQQVEL 768
Cdd:pfam07926   77 KAEAESAKAELEESEESwEEQKKELEKELSELEKRIEDLNEQNKLLHDQLES 128
PLN02939 PLN02939
transferase, transferring glycosyl groups
 305-592 8.21e-03

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 41.04  E-value: 8.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  305 EKENLQL-KSKLHDLEldrDADK--KQIEKLLEEYMVLEM-------AQKQSMKESAH---LGWELEQLSKNADLSDASR 371
Cdd:PLN02939  141 EKNILLLnQARLQALE---DLEKilTEKEALQGKINILEMrlsetdaRIKLAAQEKIHveiLEEQLEKLRNELLIRGATE 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  372 KSFVFELnecaSSRILKLEKENQSLQSTIQGLRDTSLALEESSLKYGELEKENQQLSKKIEKLQTQLEREKQSNQDLETL 451
Cdd:PLN02939  218 GLCVHSL----SKELDVLKEENMLLKDDIQFLKAELIEVAETEERVFKLEKERSLLDASLRELESKFIVAQEDVSKLSPL 293

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  452 SEELIREK-EQLQSGMEALKaDRARQIKDLEQEKGHLHqavwslrerpqvnstKDVEKENRALHQAVTeagSKLSQLELE 530
Cdd:PLN02939  294 QYDCWWEKvENLQDLLDRAT-NQVEKAALVLDQNQDLR---------------DKVDKLEASLKEANV---SKFSSYKVE 354

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755543021  531 -KQQLHRDLEEAKEKGEQaealekELHRLEKENEQLTKE----VTSLKAATEKvEALEHQSQGLELE 592
Cdd:PLN02939  355 lLQQKLKLLEERLQASDH------EIHSYIQLYQESIKEfqdtLSKLKEESKK-RSLEHPADDMPSE 414
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 168-351 8.28e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 40.58  E-value: 8.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  168 EDKQHLAVELADTKARLRRVRQELEEKTEQLADTRHEVDQLVLELQKAKQDNIQLAADARSARA-YRDELDSLREKANRV 246
Cdd:COG3883    23 KELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREeLGERARALYRSGGSV 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  247 ERLEM--------DLVRCKEKLHDV-DFYKARMEELREDNIILIETKAMLEEQLTASRAR----SDKVHELEKENLQLKS 313
Cdd:COG3883   103 SYLDVllgsesfsDFLDRLSALSKIaDADADLLEELKADKAELEAKKAELEAKLAELEALkaelEAAKAELEAQQAEQEA 182

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 755543021  314 KLHDLELDRDADKKQIEKLLEEYMVLEMAQKQSMKESA 351
Cdd:COG3883   183 LLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAA 220
PRK05431 PRK05431
seryl-tRNA synthetase; Provisional
 706-773 8.72e-03

seryl-tRNA synthetase; Provisional


Pssm-ID: 235461 [Multi-domain]  Cd Length: 425  Bit Score: 40.82  E-value: 8.72e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755543021  706 ELSQLEAERQALRRDLETLQLTHK-------QLEGAEEDRKALEQEVAQLEKDKKLLEKEARRLwqQVELKDAIL 773
Cdd:PRK05431   29 ELLELDEERRELQTELEELQAERNalskeigQAKRKGEDAEALIAEVKELKEEIKALEAELDEL--EAELEELLL 101
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
 419-590 8.82e-03

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 39.50  E-value: 8.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   419 ELEKENQQLSKKIEKLQTQLErekqsnqdletlseELIREKEQLQSGMEALKADRARqIKDLEQEKghlhqavwslrerp 498
Cdd:pfam13851   51 EIQQENKRLTEPLQKAQEEVE--------------ELRKQLENYEKDKQSLKNLKAR-LKVLEKEL-------------- 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   499 qvnstKDVEKENRALHQavteagsKLSQLELEKQQLHRDLEEA----KEK-GEQAEALEKELHRLEKENEQLTKEVTS-L 572
Cdd:pfam13851  102 -----KDLKWEHEVLEQ-------RFEKVERERDELYDKFEAAiqdvQQKtGLKNLLLEKKLQALGETLEKKEAQLNEvL 169

                          170
                   ....*....|....*...
gi 755543021   573 KAATEKVEALEHQSQGLE 590
Cdd:pfam13851  170 AAANLDPDALQAVTEKLE 187
DUF4515 pfam14988
Domain of unknown function (DUF4515); This family of proteins is found in bacteria and ...
 420-623 8.85e-03

Domain of unknown function (DUF4515); This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 198 and 469 amino acids in length. There are two completely conserved L residues that may be functionally important.


Pssm-ID: 405647 [Multi-domain]  Cd Length: 206  Bit Score: 39.75  E-value: 8.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   420 LEKENQQLSKKIEKLQTQLEREKqsnqdletlsEELIREKEQLQSGMEALKADRARQIKDLEQEKGHLHQAVWSLRERPQ 499
Cdd:pfam14988    9 LAKKTEEKQKKIEKLWNQYVQEC----------EEIERRRQELASRYTQQTAELQTQLLQKEKEQASLKKELQALRPFAK 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   500 VNSTKDVEKENRALHQAVTEAGSKLSQLELEKQQLHRDLEEAKEKGEQaealeKELHRLEKENEQLTKEVTSLKAATEKv 579
Cdd:pfam14988   79 LKESQEREIQDLEEEKEKVRAETAEKDREAHLQFLKEKALLEKQLQEL-----RILELGERATRELKRKAQALKLAAKQ- 152

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 755543021   580 eALEHQSQGLELENRSLRKSLDTL----QNVSVQLEGLERDKQQLGQE 623
Cdd:pfam14988  153 -ALSEFCRSIKRENRQLQKELLQLiqetQALEAIKSKLENRKQRLKEE 199
PRK11281 PRK11281
mechanosensitive channel MscK;
187-601 8.90e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 41.05  E-value: 8.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  187 VRQELEEKTEQLADTrhevdqlvlelQKAKQDNIQL---AADA-RSARAYRDELDSLREKANR----------VERLEMD 252
Cdd:PRK11281   61 VQQDLEQTLALLDKI-----------DRQKEETEQLkqqLAQApAKLRQAQAELEALKDDNDEetretlstlsLRQLESR 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  253 LVRCKEKLHDVDfykarmEELREDNIILIETKAMLEE---QLTASRARSDKVhelekeNLQLKSKLHDLELDRDAdkkQI 329
Cdd:PRK11281  130 LAQTLDQLQNAQ------NDLAEYNSQLVSLQTQPERaqaALYANSQRLQQI------RNLLKGGKVGGKALRPS---QR 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  330 EKLLEEYMVLEMAQKQSMKEsahlgweLEQLSKNADLSDASRksfvfelnECASSRILKLEKENQSLQSTIQGLRdtsLA 409
Cdd:PRK11281  195 VLLQAEQALLNAQNDLQRKS-------LEGNTQLQDLLQKQR--------DYLTARIQRLEHQLQLLQEAINSKR---LT 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  410 LEESSLKygelEKENQQLSKKIEK---LQTQLEREKQSNQDL-------ETLSEELIREKEQLQSgmeALKADRA--RQI 477
Cdd:PRK11281  257 LSEKTVQ----EAQSQDEAARIQAnplVAQELEINLQLSQRLlkateklNTLTQQNLRVKNWLDR---LTQSERNikEQI 329

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  478 KDLeqeKGHL------HQAVWSLrerPQVNSTKDVEKE--NRALHQ-AVTEAGSKLSQLE-----LEKQQ-------LHR 536
Cdd:PRK11281  330 SVL---KGSLllsrilYQQQQAL---PSADLIEGLADRiaDLRLEQfEINQQRDALFQPDayidkLEAGHksevtdeVRD 403

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755543021  537 DLEE-AKEKGEQAEALEKELhrlekeNEQLTKEVTslkaatekveaLEHQSQGLELENRSLRKSLD 601
Cdd:PRK11281  404 ALLQlLDERRELLDQLNKQL------NNQLNLAIN-----------LQLNQQQLLSVSDSLQSTLT 452
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
 271-617 9.11e-03

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 40.82  E-value: 9.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   271 EELREDNIILIETKAMLEEQLTASRArsdkvhelekenlqLKSKLHDLELDRDADKKQIEKLLEEYMVLEMAQKQSMKES 350
Cdd:pfam19220   41 RELPQAKSRLLELEALLAQERAAYGK--------------LRRELAGLTRRLSAAEGELEELVARLAKLEAALREAEAAK 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   351 AHLGWELEQlsKNADLSDASRKSFVfelnecASSRILKLEKENQSLQSTIQGLrDTSLALEESSL-----KYGELEKENQ 425
Cdd:pfam19220  107 EELRIELRD--KTAQAEALERQLAA------ETEQNRALEEENKALREEAQAA-EKALQRAEGELatareRLALLEQENR 177

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   426 QLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEALKADRARQIKDLEQEKGHLHQAVWSLRER-----PQV 500
Cdd:pfam19220  178 RLQALSEEQAAELAELTRRLAELETQLDATRARLRALEGQLAAEQAERERAEAQLEEAVEAHRAERASLRMKlealtARA 257

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021   501 NSTKDVEKENRALHQAVTEAG----SKLSQLELEKQQLHRDLEEAKEKGEQAEALEKELHR----LEKENEQLTKEVTS- 571
Cdd:pfam19220  258 AATEQLLAEARNQLRDRDEAIraaeRRLKEASIERDTLERRLAGLEADLERRTQQFQEMQRaraeLEERAEMLTKALAAk 337

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*....
gi 755543021   572 ---LKAATEKVEALehQSQGLELENRSLRKSLDTLQNVSVQLEGLERDK 617
Cdd:pfam19220  338 daaLERAEERIASL--SDRIAELTKRFEVERAALEQANRRLKEELQRER 384
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
419-580 9.74e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 40.28  E-value: 9.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  419 ELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEALKADRA--RQIKDLEQEKGHLHQAVWSLRE 496
Cdd:COG1340    82 ELNEKLNELREELDELRKELAELNKAGGSIDKLRKEIERLEWRQQTEVLSPEEEKElvEKIKELEKELEKAKKALEKNEK 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  497 -RPQVNSTKDVEKENRALHQAVTEAGSKLSQLELEKQQLHRDLEE-----------AKEKGEQAEALEKELHRLEKENEQ 564
Cdd:COG1340   162 lKELRAELKELRKEAEEIHKKIKELAEEAQELHEEMIELYKEADElrkeadelhkeIVEAQEKADELHEEIIELQKELRE 241

                         170
                  ....*....|....*.
gi 755543021  565 LTKEVTSLKAATEKVE 580
Cdd:COG1340   242 LRKELKKLRKKQRALK 257
46 PHA02562
endonuclease subunit; Provisional
 649-871 9.95e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 40.77  E-value: 9.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  649 RQLEREKEELRRDVELLKTLSKKSERLELSYQSVSAENLQ-LQHSLESSTHKSQALQRELSQLEAERQALRRDLETLQLT 727
Cdd:PHA02562  177 RELNQQIQTLDMKIDHIQQQIKTYNKNIEEQRKKNGENIArKQNKYDELVEEAKTIKAEIEELTDELLNLVMDIEDPSAA 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755543021  728 HKQLEGAEEDRKAleqEVAQLEKDKKLLEK--EARRLWQQVELKDAILDDSAAKLSAAEKESRALDKELARCRDVGSKLK 805
Cdd:PHA02562  257 LNKLNTAAAKIKS---KIEQFQKVIKMYEKggVCPTCTQQISEGPDRITKIKDKLKELQHSLEKLDTAIDELEEIMDEFN 333

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755543021  806 ELEKDNRDLTKQVTMHTRTLTTLREDL-----VLEKLKSQQL--SSELDKLSQELEKVGLSKDLLLQEDDGHG 871
Cdd:PHA02562  334 EQSKKLLELKNKISTNKQSLITLVDKAkkvkaAIEELQAEFVdnAEELAKLQDELDKIVKTKSELVKEKYHRG 406
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH