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Conserved domains on  [gi|755555878|ref|XP_011244564|]
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G1/S-specific cyclin-D3 isoform X3 [Mus musculus]

Protein Classification

cyclin family protein( domain architecture ID 1750054)

cyclin family protein may associate with and activate its cognate cyclin-dependent kinase (CDK)

CATH:  1.10.472.10
Gene Ontology:  GO:0000079|GO:0019901|GO:0007049
PubMed:  14744433|30185601|15269391|15840440
SCOP:  4001102

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_SF super family cl40454
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 108-212 1.95e-68

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


The actual alignment was detected with superfamily member cd20578:

Pssm-ID: 477360  Cd Length: 105  Bit Score: 206.06  E-value: 1.95e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555878 108 IAHDFLALILHRLSLPSDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVLGLGACSMSADELTELLAGITGT 187
Cdd:cd20578    1 IAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGT 80

                         90       100
                 ....*....|....*....|....*
gi 755555878 188 EVDCLRACQEQIEAALRESLREAAQ 212
Cdd:cd20578   81 EVDCLRACQEQIEAALRESLREASQ 105
CYCLIN_SF super family cl40454
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 19-103 3.12e-56

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


The actual alignment was detected with superfamily member cd20575:

Pssm-ID: 477360  Cd Length: 150  Bit Score: 176.72  E-value: 3.12e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555878  19 VCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLG 98
Cdd:cd20575   66 VCEEQKCEEEVFPLAMNYVDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDNSISPRQLLDWEILVLG 145


                 ....*
gi 755555878  99 KLKWD 103
Cdd:cd20575  146 KLKWD 150
 
Name Accession Description Interval E-value
CYCLIN_CCND3_rpt2 cd20578
second cyclin box found in G1/S-specific cyclin-D3 (CCND3); CCND3 is a regulatory component of ...
 108-212 1.95e-68

second cyclin box found in G1/S-specific cyclin-D3 (CCND3); CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410281  Cd Length: 105  Bit Score: 206.06  E-value: 1.95e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555878 108 IAHDFLALILHRLSLPSDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVLGLGACSMSADELTELLAGITGT 187
Cdd:cd20578    1 IAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGT 80

                         90       100
                 ....*....|....*....|....*
gi 755555878 188 EVDCLRACQEQIEAALRESLREAAQ 212
Cdd:cd20578   81 EVDCLRACQEQIEAALRESLREASQ 105
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 19-103 3.12e-56

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 176.72  E-value: 3.12e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555878  19 VCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLG 98
Cdd:cd20575   66 VCEEQKCEEEVFPLAMNYVDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDNSISPRQLLDWEILVLG 145


                 ....*
gi 755555878  99 KLKWD 103
Cdd:cd20575  146 KLKWD 150
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 19-105 1.48e-29

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 107.22  E-value: 1.48e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555878   19 VCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLG 98
Cdd:pfam00134  41 VHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTCLFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILE 120


                  ....*..
gi 755555878   99 KLKWDLA 105
Cdd:pfam00134 121 TLNFDLS 127
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 107-203 1.09e-15

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 70.73  E-value: 1.09e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555878  107 VIAHDFLALILHRLSLPSDRQalVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVLGLGACsmsadELTELLAGITG 186
Cdd:pfam02984   1 PTPLSFLRRFSKAADYLHDLE--LRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLNSP-----EWTETLEHYTG 73

                          90
                  ....*....|....*..
gi 755555878  187 TEVDCLRACQEQIEAAL 203
Cdd:pfam02984  74 YSEEDLKPCVKLLLELL 90
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 19-97 5.07e-12

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 59.91  E-value: 5.07e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755555878    19 VCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVApwQLREWEVLVL 97
Cdd:smart00385   6 VCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGYFTEE--EILRMERLLL 82
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
28-159 3.31e-09

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 56.32  E-value: 3.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555878  28 DVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLGKLKWDLAAV 107
Cdd:COG5024  232 ETLFLAINIIDRFLSSRVVSLEKYQLVGISALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWP 311

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 755555878 108 IAHDFlaliLHRLSLPSDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGS 159
Cdd:COG5024  312 SPMSF----LRRISKASDYDIFSRTPAKFSSEISPVDYKFIQISPSWCAAAA 359
 
Name Accession Description Interval E-value
CYCLIN_CCND3_rpt2 cd20578
second cyclin box found in G1/S-specific cyclin-D3 (CCND3); CCND3 is a regulatory component of ...
 108-212 1.95e-68

second cyclin box found in G1/S-specific cyclin-D3 (CCND3); CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410281  Cd Length: 105  Bit Score: 206.06  E-value: 1.95e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555878 108 IAHDFLALILHRLSLPSDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVLGLGACSMSADELTELLAGITGT 187
Cdd:cd20578    1 IAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGT 80

                         90       100
                 ....*....|....*....|....*
gi 755555878 188 EVDCLRACQEQIEAALRESLREAAQ 212
Cdd:cd20578   81 EVDCLRACQEQIEAALRESLREASQ 105
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 19-103 3.12e-56

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 176.72  E-value: 3.12e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555878  19 VCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLG 98
Cdd:cd20575   66 VCEEQKCEEEVFPLAMNYVDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDNSISPRQLLDWEILVLG 145


                 ....*
gi 755555878  99 KLKWD 103
Cdd:cd20575  146 KLKWD 150
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 19-103 8.90e-54

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 170.17  E-value: 8.90e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555878  19 VCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLG 98
Cdd:cd20515   66 VCEEQNCEEEVFPLAVNYLDRFLSLVPIRKSQLQLLGAVCLFLASKLKETIPLTAEKLCIYTDNSITLQELLDWELLVLT 145


                 ....*
gi 755555878  99 KLKWD 103
Cdd:cd20515  146 KLKWD 150
CYCLIN_CCND2_rpt2 cd20577
second cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 110-208 3.95e-47

second cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410280  Cd Length: 105  Bit Score: 151.92  E-value: 3.95e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555878 110 HDFLALILHRLSLPSDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVLGL----GACSMSADELTELLAGIT 185
Cdd:cd20577    3 HDFIEHILRKLPLPKDKLPLIRKHAQTFIALCATDFKFAMYPPSMIATGSVGAAICGLqldrGDSSLSGDSLTELLAKIT 82

                         90       100
                 ....*....|....*....|...
gi 755555878 186 GTEVDCLRACQEQIEAALRESLR 208
Cdd:cd20577   83 NTDVDCLKACQEQIESVLVSNLR 105
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 19-103 7.30e-47

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 152.84  E-value: 7.30e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555878  19 VCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLG 98
Cdd:cd20574   66 VCEEQKCEEEVFPLAMNYLDRFLAVVPTRKCHLQLLGAVCMFLASKLKETIPLTAEKLCIYTDNSIKPQELLEWELVVLG 145


                 ....*
gi 755555878  99 KLKWD 103
Cdd:cd20574  146 KLKWN 150
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 19-103 3.60e-41

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 138.19  E-value: 3.60e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555878  19 VCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLG 98
Cdd:cd20573   65 VCEEQKCEEEVFPLAMNYLDRFLSVEPTKKSRLQLLGATCMFLASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLVLN 144


                 ....*
gi 755555878  99 KLKWD 103
Cdd:cd20573  145 KLKWD 149
CYCLIN_CCND_rpt2 cd20516
second cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 108-204 2.94e-40

second cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410220  Cd Length: 98  Bit Score: 133.89  E-value: 2.94e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555878 108 IAHDFLALILHRLSLPSDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVLGLGACSM-SADELTELLAGITG 186
Cdd:cd20516    1 TPLDFLEHILHRLPLDSEDVDKVRKHAETFIALCATDYKFSSYPPSMIAAASILAALRGLLLHSGnSKEDLLEKLQQLTR 80

                         90
                 ....*....|....*...
gi 755555878 187 TEVDCLRACQEQIEAALR 204
Cdd:cd20516   81 IDEDLLRACQEQIEDLLE 98
CYCLIN_CCND1_rpt2 cd20576
second cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 110-212 2.25e-32

second cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410279  Cd Length: 110  Bit Score: 114.28  E-value: 2.25e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555878 110 HDFLALILHRLSLPSDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVLGLGACS----MSADELTELLAGIT 185
Cdd:cd20576    3 HDFIEHFLSKMPLAEDTKQIIRKHAQTFVALCATDVKFISNPPSMIAAGSVAAAVQGLNLGNtnsfLSYQRLTRFLSQVI 82

                         90       100
                 ....*....|....*....|....*..
gi 755555878 186 GTEVDCLRACQEQIEAALRESLREAAQ 212
Cdd:cd20576   83 KCDPDCLRACQEQIESLLESSLRQAQQ 109
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 19-105 1.48e-29

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 107.22  E-value: 1.48e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555878   19 VCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLG 98
Cdd:pfam00134  41 VHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTCLFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILE 120


                  ....*..
gi 755555878   99 KLKWDLA 105
Cdd:pfam00134 121 TLNFDLS 127
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 19-101 3.90e-16

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 72.28  E-value: 3.90e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555878  19 VCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLG 98
Cdd:cd20504   45 VAEEYKLVPETLYLAVNYIDRFLSQMSVLRSKLQLVGTACMFIAAKYEEIYPPEVEEFVYITDDTYTKKQVLRMEHLVLK 124


                 ...
gi 755555878  99 KLK 101
Cdd:cd20504  125 VLS 127
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 107-203 1.09e-15

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 70.73  E-value: 1.09e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555878  107 VIAHDFLALILHRLSLPSDRQalVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVLGLGACsmsadELTELLAGITG 186
Cdd:pfam02984   1 PTPLSFLRRFSKAADYLHDLE--LRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLNSP-----EWTETLEHYTG 73

                          90
                  ....*....|....*..
gi 755555878  187 TEVDCLRACQEQIEAAL 203
Cdd:pfam02984  74 YSEEDLKPCVKLLLELL 90
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 19-102 1.24e-15

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 71.19  E-value: 1.24e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555878  19 VCEEQRCEEDVFPLAMNYLDRYLSCVP-TRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVL 97
Cdd:cd20519   47 VCEVYRLHRETFYLAVDFVDRYLSTQTnVPKTQLQLIGITCLFIAAKLEEIYPPKLSEFAYVTDGACTEDEILTMELIIL 126


                 ....*
gi 755555878  98 GKLKW 102
Cdd:cd20519  127 KALNW 131
CYCLIN_vCyC_rpt1 cd20517
first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle ...
 18-102 6.21e-15

first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410221  Cd Length: 99  Bit Score: 68.36  E-value: 6.21e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555878  18 CVCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVL 97
Cdd:cd20517   15 LVCESFELDKNVFPLAVSLLDRLLLKKQGTKETLQKTGAACLLIASKIRTVKPITVSKLTYLSCDCFTNLELINQEKDIL 94


                 ....*
gi 755555878  98 GKLKW 102
Cdd:cd20517   95 EALKW 99
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 19-104 9.88e-15

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 67.73  E-value: 9.88e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555878  19 VCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLG 98
Cdd:cd20542   11 VQEHLELSTQTLHLAVALLDRYLSRQKISLSLLQLLGITCLFIACKFEERFPPEVATLCYLTDDSYSKKQVLRMERRVLR 90


                 ....*.
gi 755555878  99 KLKWDL 104
Cdd:cd20542   91 RLRFDL 96
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 19-103 9.46e-13

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 63.54  E-value: 9.46e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555878  19 VCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLG 98
Cdd:cd20561   47 VGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLK 126


                 ....*
gi 755555878  99 KLKWD 103
Cdd:cd20561  127 VLTFD 131
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 19-103 1.09e-12

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 63.20  E-value: 1.09e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555878  19 VCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLG 98
Cdd:cd20562   52 VAEEYKLVPDTLYLTVSYIDRFLSGNYVNRQRLQLLGVSCMLIASKYEEICAPQVEEFCYITDNTYTKQEVLEMEIDVLN 131


                 ....*
gi 755555878  99 KLKWD 103
Cdd:cd20562  132 ALQFE 136
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 19-103 1.61e-12

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 63.32  E-value: 1.61e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555878  19 VCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLG 98
Cdd:cd20560   79 VGEEYKLQTETLYLAVNYLDRFLSCMSVLRGKLQLVGTAAILLASKYEEIYPPEVDEFVYITDDTYTKKQLLRMEHLLLK 158


                 ....*
gi 755555878  99 KLKWD 103
Cdd:cd20560  159 VLAFD 163
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 19-97 5.07e-12

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 59.91  E-value: 5.07e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755555878    19 VCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVApwQLREWEVLVL 97
Cdd:smart00385   6 VCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGYFTEE--EILRMERLLL 82
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 32-101 6.43e-11

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 58.31  E-value: 6.43e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555878  32 LAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLGKLK 101
Cdd:cd20507   60 LTVNIIDRYLSKKQVPRKKLQLVGVTALLIASKYEEIYPPEIKDFVYITDNAYTREEILQMERDILKTLD 129
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 32-102 1.05e-09

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 54.25  E-value: 1.05e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755555878  32 LAMNYLDRYLSCVPTRKAQ---LQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAV-APWQLREWEVLVLGKLKW 102
Cdd:cd20543   25 LAVNYLDRFLSSYDLPKDKpwmLQLLAVACLSLAAKMEETDVPLLVDLQVEEPKYVfEAKTIQRMELLVLSTLEW 99
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
28-159 3.31e-09

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 56.32  E-value: 3.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555878  28 DVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLGKLKWDLAAV 107
Cdd:COG5024  232 ETLFLAINIIDRFLSSRVVSLEKYQLVGISALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWP 311

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 755555878 108 IAHDFlaliLHRLSLPSDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGS 159
Cdd:COG5024  312 SPMSF----LRRISKASDYDIFSRTPAKFSSEISPVDYKFIQISPSWCAAAA 359
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 32-102 9.78e-09

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 52.73  E-value: 9.78e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755555878  32 LAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLGKLKW 102
Cdd:cd20567   77 LTVNLIDRFLSVKQVPRKELQLVGVTAMLIASKYEEIWAPEVNDFVYISDNAYTRKQILVMEKTMLNTLEF 147
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 19-102 1.20e-08

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 52.19  E-value: 1.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555878  19 VCEEQRCEEDVFPLAMNYLDRYLSCVPTR-KAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVL 97
Cdd:cd20579   53 VCEVYKLHRETFYLAQDFFDRFMATQENVvKTRLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIM 132


                 ....*
gi 755555878  98 GKLKW 102
Cdd:cd20579  133 KALKW 137
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 19-93 1.70e-08

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 50.49  E-value: 1.70e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755555878  19 VCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLREtTPLTIEKLCIYTDqaVAPWQLREWE 93
Cdd:cd00043    9 LCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEE-LPRTLKEIAKVSG--VSEKELRKAE 80
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 37-102 2.73e-08

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 51.02  E-value: 2.73e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755555878  37 LDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLGKLKW 102
Cdd:cd20566   68 MDRFLQVQPVSRKKLQLVGVTALLLASKYEEMYSPEIGDFVYITDNAYTKAQIREMEMLILKELNF 133
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 25-100 3.15e-08

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 50.02  E-value: 3.15e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755555878  25 CEEDVFpLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLGKL 100
Cdd:cd20536   19 SQETLF-LAVNILDRFLATTPVARDCFQLLGVTSLLIACKQEEIYPPEVKDLLALCCGAYTREQICNLECIILTKL 93
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 19-102 1.06e-07

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 49.46  E-value: 1.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555878  19 VCEEQRCEEDVFPLAMNYLDRY-LSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVL 97
Cdd:cd20580   53 VCEVYTLHRETFYLAQDFFDRFmLTQKNINKSMLQLIGITSLFIASKLEEIYPPKLHEFAYVTDGACSEDDILDMELIIL 132


                 ....*
gi 755555878  98 GKLKW 102
Cdd:cd20580  133 KALKW 137
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 28-103 1.34e-07

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 48.15  E-value: 1.34e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755555878  28 DVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTP--LTIEKLCIYTDQAVAPWQLREWEVLVLGKLKWD 103
Cdd:cd20559   18 QTFFLSVNLIDRYCSKRIVLKKHYQLVGCTCLWIASKFWESKArvPLLSELSKMCCNSYGEELFIQMEMHILNTLNWD 95
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 37-102 1.93e-07

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 48.72  E-value: 1.93e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755555878  37 LDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLGKLKW 102
Cdd:cd20565   64 IDRFLQNNPVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALDF 129
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 32-102 2.93e-06

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 45.36  E-value: 2.93e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755555878  32 LAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLGKLKW 102
Cdd:cd20568   64 LAVNIIDRFLSKRVVSLNKLQLVGISALFIASKYEEVNSPSIKNFAYMTDGAYTVEDILRAERYMLNTLEF 134
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 32-103 3.87e-06

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 45.32  E-value: 3.87e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755555878  32 LAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLGKLKWD 103
Cdd:cd20508   71 LAVKLVDLYLSKKVVKKEKLQLLGATAILIASKFDERCPPCVDDFLYICDDAYTREELLKMEREILKTLDFD 142
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 18-102 4.95e-06

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 44.13  E-value: 4.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555878  18 CVCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLT--IEKLCIYTDQAVAPWQ-LREWEV 94
Cdd:cd20528   16 VVSERLKLSDTTLHLAVYLLDRFMDRYDISEDQLHLVALTCLLLAAKFEELDDNIpkISDLNRYLCNSVYSKQeYLQMEL 95


                 ....*...
gi 755555878  95 LVLGKLKW 102
Cdd:cd20528   96 LILEFFQW 103
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 32-81 8.05e-06

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 43.46  E-value: 8.05e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 755555878  32 LAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTD 81
Cdd:cd20521   27 VAVSCVDRYLMVRKVPRSKLQLLGIACMVIATRFLGKDILTIREAAWLTD 76
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 30-104 2.22e-05

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 42.30  E-value: 2.22e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755555878  30 FPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTP--LTIEKLCIYTDQAVAPWQLREWEVLVLGKLKWDL 104
Cdd:cd20526   23 FALAVSILDRFLASVKARPKYLRCIAISCLFLAAKTNEEDEviPSTKDLVRVSKCGCSVAEVLRMERIILDKLHWDL 99
CYCLIN_AtCycD-like_rpt2 cd20544
second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant ...
 107-199 2.38e-04

second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410247  Cd Length: 90  Bit Score: 38.83  E-value: 2.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555878 107 VIAHDFLALILHRLSLPSDRQALVKKHAQTFLALCAtDYTFAMYPPSMIATGSIGAAVLGLGACSMSADELTELLAGItg 186
Cdd:cd20544    1 VTPFSFLDYFISKIGLSDSREELLSRATELLLSTTK-DIRFLEYRPSVIAAAAILCALDELPPDDADDASSRLSLLLS-- 77

                         90
                 ....*....|...
gi 755555878 187 TEVDCLRACQEQI 199
Cdd:cd20544   78 PNKEKVKKCYELM 90
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 32-160 9.40e-04

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 39.72  E-value: 9.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555878  32 LAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTP-LTIEKLCIYTDQAVAPWQLR----EWEVLVLGKLKWDLAA 106
Cdd:COG5333   68 TAILFFSRFYLKNSVEEISLYSVVTTCVYLACKVEDTPRdISIESFEARDLWSEEPKSSRerilEYEFELLEALDFDLHV 147

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 755555878 107 VIAHDFLALILH--RLSLPSDRQALVKKHAQTFLALcatdYTFAMYPPSMIATGSI 160
Cdd:COG5333  148 HHPYKYLEGFLKdlQEKDKYKLLQIAWKIINDALRT----DLCLLYPPHIIALAAL 199
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 109-199 1.56e-03

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 36.90  E-value: 1.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555878 109 AHDFLALILHRLSLPSDRQALvkkhAQTFLALCATDYTFAMYPPSMIATGSIgaaVLGLGACSMSADElTELLAGITGTE 188
Cdd:cd20537    3 PLSFLRRYLSLLGLDEKVRHL----ARYLLELSLLDYEFLKYRPSLIAAAAL---YLARKILGEPPPS-PQLLQLVTGYS 74

                         90
                 ....*....|.
gi 755555878 189 VDCLRACQEQI 199
Cdd:cd20537   75 ENDLQECAKEL 85
CYCLIN_vCyC_rpt2 cd20518
second cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle ...
 108-205 2.63e-03

second cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410222  Cd Length: 100  Bit Score: 36.38  E-value: 2.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555878 108 IAHDFLALILHRLSLPSDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVLGLGACSMSADELTELLAGITGT 187
Cdd:cd20518    1 LATDVTSPLLLKLKGGSDQLDALHHAVNTLITKALVDPNTGSLPPSLISAAGCLLLVPANVTPQTHSGGVLPRLASILGC 80

                         90
                 ....*....|....*...
gi 755555878 188 EVDCLRACQEQIEAALRE 205
Cdd:cd20518   81 SVSTLQAAVEQVLTSLSD 98
CYCLIN_CCNG cd20523
cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 ...
 28-68 6.51e-03

cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 and CCNG2. CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410227  Cd Length: 94  Bit Score: 35.02  E-value: 6.51e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 755555878  28 DVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRET 68
Cdd:cd20523   20 ETFALAVNLLDRFLSKVKVKPKHLACITVSCFHIAIKSVEE 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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