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Conserved domains on  [gi|755565528|ref|XP_011245922|]
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fibronectin type III domain containing protein 3C1 isoform X2 [Mus musculus]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 13457450)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
934-1166 6.15e-20

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 95.84  E-value: 6.15e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  934 YEVKGLVPATTYFCRVQAVNIVGVGMFGGTAKVTTPGTVPAMVPVLKEVEskvpakLSSTCIAIRWEEPDchGSPITGYN 1013
Cdd:COG3401   194 DGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATA------DTPGSVTLSWDPVT--ESDATGYR 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528 1014 IEYGDKKVVTVKRI-----TEYVLKDLQPNTTYRIRIQAINHYGL-SPFSPSIRCKTKPLPPEPPQ-LNCVVYGHQSLRL 1086
Cdd:COG3401   266 VYRSNSGDGPFTKVatvttTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSgLTATAVGSSSITL 345

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528 1087 KWGTVSSkktlANFINYNVL-MEDRSGRFSVIYRGPDVT-HKVQKLSEYTEYKFKIQACNEAG-EGPESDIYTFTTTKSP 1163
Cdd:COG3401   346 SWTASSD----ADVTGYNVYrSTSGGGTYTKIAETVTTTsYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAA 421


                  ...
gi 755565528 1164 PTA 1166
Cdd:COG3401   422 SGE 424
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 515-605 3.77e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 72.14  E-value: 3.77e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  515 PDPPLAPTLISRTKNSLSLQWKASNDNGSKISSFLLEWDEGKGEDFKSCYSGRLKQ--HKLFKLNPSTKYSFRLAAKNDF 592
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSEtsYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 755565528  593 GCSNFSETAVFYT 605
Cdd:cd00063    81 GESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 879-968 2.19e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.66  E-value: 2.19e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  879 PSQCGTPVLTCKGPTCVIVSWEIPKCNGAEIIDYRLQWGQVEDSMHLIYTGPC---LRYEVKGLVPATTYFCRVQAVNIV 955
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPgseTSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 755565528  956 GVGMFGGTAKVTT 968
Cdd:cd00063    81 GESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 625-702 6.34e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.42  E-value: 6.34e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755565528  625 SLSLEWCAPTNPNPNDTlTYVLEMEEAKSGLGFK-PKYNGEDLTCTIRNLQRNTMYKFRIFAYNLEGRSNPSGEVKYTT 702
Cdd:cd00063    16 SVTLSWTPPEDDGGPIT-GYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
672-808 6.49e-09

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 60.40  E-value: 6.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  672 NLQRNTMYKFRIFAYNLEGRSNPSGEVKYTTRPARPGCPnKPYVVGTIHAHQVTIGWDlpkDNGGMNISSYSLEVCENSD 751
Cdd:COG3401   198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAP-TGLTATADTPGSVTLSWD---PVTESDATGYRVYRSNSGD 273

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 755565528  752 SAnlWKIIYSGTRQEFLYDDLQAATTYKLRVFCTSPAG-QSRPSDVLTIQTPTLPPES 808
Cdd:COG3401   274 GP--FTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAA 329
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
301-728 1.05e-07

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 56.55  E-value: 1.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  301 CSDNNNNITDSSISNYNQVTYDETHKPPDAKSIPSCTSQSASNPSVSENAHNPSSINDGLRPSDVASISENDHEETEANM 380
Cdd:COG3401    23 VNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGS 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  381 GAGDNKQILGENQKKSQSSNASLKEHNTEDRTQPGcFNIEKPVVSNIQTRSATVSWTRKSNEKYDINSSMTHELALSSNG 460
Cdd:COG3401   103 VGGATNTGLTSSDEVPSPAVGTATTATAVAGGAAT-AGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVA 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  461 KNGTYKNIYTGNGVTVvlhDLQPCMVYFLRVTTIRNAEHRSVSEVVSFTTPGCEPDPPLAPTLISRTKNSLSLQWKASND 540
Cdd:COG3401   182 TTSLTVTSTTLVDGGG---DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTE 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  541 NGskISSFLLEWDEGKGEDFKSCYSGRLKQHKLFKLNPSTKYSFRLAAKNDFGC-SNFSETAVFYTSGKTPPAPLPPKLK 619
Cdd:COG3401   259 SD--ATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSGLTAT 336

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  620 EAGIYSLSLEWCAPTNPnpnDTLTYVLEMEEAKSGLGFKPKYNGEDLTCTIRNLQRNTMYKFRIFAYNLEGR-SNPSGEV 698
Cdd:COG3401   337 AVGSSSITLSWTASSDA---DVTGYNVYRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNeSAPSEEV 413

                         410       420       430
                  ....*....|....*....|....*....|
gi 755565528  699 KYTTRPARPGCPNKPYVVGTIHAHQVTIGW 728
Cdd:COG3401   414 SATTASAASGESLTASVDAVPLTDVAGATA 443
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1164-1260 5.18e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.48  E-value: 5.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528 1164 PTALKAPKVHPLNNNSCEIKWESLEPIKGDPIVYCLQVTTGKKAN----QIYKGPNTSFSFSNYHANSRYRFKVCAgrry 1239
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDwkevEVTPGSETSYTLTGLKPGTEYEFRVRA---- 76

                          90       100
                  ....*....|....*....|.
gi 755565528 1240 ETSNGlqelWGPYSPSALFST 1260
Cdd:cd00063    77 VNGGG----ESPPSESVTVTT 93
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
934-1166 6.15e-20

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 95.84  E-value: 6.15e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  934 YEVKGLVPATTYFCRVQAVNIVGVGMFGGTAKVTTPGTVPAMVPVLKEVEskvpakLSSTCIAIRWEEPDchGSPITGYN 1013
Cdd:COG3401   194 DGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATA------DTPGSVTLSWDPVT--ESDATGYR 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528 1014 IEYGDKKVVTVKRI-----TEYVLKDLQPNTTYRIRIQAINHYGL-SPFSPSIRCKTKPLPPEPPQ-LNCVVYGHQSLRL 1086
Cdd:COG3401   266 VYRSNSGDGPFTKVatvttTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSgLTATAVGSSSITL 345

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528 1087 KWGTVSSkktlANFINYNVL-MEDRSGRFSVIYRGPDVT-HKVQKLSEYTEYKFKIQACNEAG-EGPESDIYTFTTTKSP 1163
Cdd:COG3401   346 SWTASSD----ADVTGYNVYrSTSGGGTYTKIAETVTTTsYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAA 421


                  ...
gi 755565528 1164 PTA 1166
Cdd:COG3401   422 SGE 424
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 990-1064 6.83e-17

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 77.15  E-value: 6.83e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  990 LSSTCIAIRWEEPDCHGSPITGYNIEYGDKKVVTVKRI-------TEYVLKDLQPNTTYRIRIQAINHYGLSPFSPSIRC 1062
Cdd:cd00063    12 VTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVevtpgseTSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTV 91


                  ..
gi 755565528 1063 KT 1064
Cdd:cd00063    92 TT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 515-605 3.77e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 72.14  E-value: 3.77e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  515 PDPPLAPTLISRTKNSLSLQWKASNDNGSKISSFLLEWDEGKGEDFKSCYSGRLKQ--HKLFKLNPSTKYSFRLAAKNDF 592
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSEtsYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 755565528  593 GCSNFSETAVFYT 605
Cdd:cd00063    81 GESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
990-1057 7.39e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.13  E-value: 7.39e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755565528   990 LSSTCIAIRWEEPDCHGSPITGYNIEY------GDKKVVTVKR-ITEYVLKDLQPNTTYRIRIQAINHYGLSPFS 1057
Cdd:pfam00041   11 VTSTSLTVSWTPPPDGNGPITGYEVEYrpknsgEPWNEITVPGtTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 991-1054 8.16e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 62.25  E-value: 8.16e-12
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755565528    991 SSTCIAIRWEEP--DCHGSPITGYNIEYGD-----KKVVTVKRITEYVLKDLQPNTTYRIRIQAINHYGLS 1054
Cdd:smart00060   13 TSTSVTLSWEPPpdDGITGYIVGYRVEYREegsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 879-968 2.19e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.66  E-value: 2.19e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  879 PSQCGTPVLTCKGPTCVIVSWEIPKCNGAEIIDYRLQWGQVEDSMHLIYTGPC---LRYEVKGLVPATTYFCRVQAVNIV 955
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPgseTSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 755565528  956 GVGMFGGTAKVTT 968
Cdd:cd00063    81 GESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
516-598 1.06e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 56.27  E-value: 1.06e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528   516 DPPLAPTLISRTKNSLSLQWKASNDNGSKISSFLLE-WDEGKGEDFKSCY-SGRLKQHKLFKLNPSTKYSFRLAAKNDFG 593
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEyRPKNSGEPWNEITvPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 755565528   594 CSNFS 598
Cdd:pfam00041   81 EGPPS 85
fn3 pfam00041
Fibronectin type III domain;
891-960 2.68e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 2.68e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755565528   891 GPTCVIVSWEIPKCNGAEIIDYRLQWGQV---EDSMHLIYTGPCLRYEVKGLVPATTYFCRVQAVNIVGVGMF 960
Cdd:pfam00041   12 TSTSLTVSWTPPPDGNGPITGYEVEYRPKnsgEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 515-595 5.38e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.16  E-value: 5.38e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528    515 PDPPLAPTLISRTKNSLSLQWKASNDNG--SKISSFLLEWDEGKGEDFKSCYSGRLKQHKLFKLNPSTKYSFRLAAKNDF 592
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 755565528    593 GCS 595
Cdd:smart00060   81 GEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 625-702 6.34e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.42  E-value: 6.34e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755565528  625 SLSLEWCAPTNPNPNDTlTYVLEMEEAKSGLGFK-PKYNGEDLTCTIRNLQRNTMYKFRIFAYNLEGRSNPSGEVKYTT 702
Cdd:cd00063    16 SVTLSWTPPEDDGGPIT-GYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
672-808 6.49e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 60.40  E-value: 6.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  672 NLQRNTMYKFRIFAYNLEGRSNPSGEVKYTTRPARPGCPnKPYVVGTIHAHQVTIGWDlpkDNGGMNISSYSLEVCENSD 751
Cdd:COG3401   198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAP-TGLTATADTPGSVTLSWD---PVTESDATGYRVYRSNSGD 273

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 755565528  752 SAnlWKIIYSGTRQEFLYDDLQAATTYKLRVFCTSPAG-QSRPSDVLTIQTPTLPPES 808
Cdd:COG3401   274 GP--FTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAA 329
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 879-958 6.94e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.16  E-value: 6.94e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528    879 PSQCGTPVLTCKGPTCVIVSWEIPKCNGAE--IIDYRLQWGQVEDS-MHLIYTGPCLRYEVKGLVPATTYFCRVQAVNIV 955
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEwKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 755565528    956 GVG 958
Cdd:smart00060   81 GEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 716-801 6.99e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.42  E-value: 6.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  716 VGTIHAHQVTIGWDLPKDNGGmNISSYSLEVCENSDSAnlWKII--YSGTRQEFLYDDLQAATTYKLRVFCTSPAGQSRP 793
Cdd:cd00063     9 VTDVTSTSVTLSWTPPEDDGG-PITGYVVEYREKGSGD--WKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPP 85


                  ....*...
gi 755565528  794 SDVLTIQT 801
Cdd:cd00063    86 SESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
301-728 1.05e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 56.55  E-value: 1.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  301 CSDNNNNITDSSISNYNQVTYDETHKPPDAKSIPSCTSQSASNPSVSENAHNPSSINDGLRPSDVASISENDHEETEANM 380
Cdd:COG3401    23 VNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGS 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  381 GAGDNKQILGENQKKSQSSNASLKEHNTEDRTQPGcFNIEKPVVSNIQTRSATVSWTRKSNEKYDINSSMTHELALSSNG 460
Cdd:COG3401   103 VGGATNTGLTSSDEVPSPAVGTATTATAVAGGAAT-AGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVA 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  461 KNGTYKNIYTGNGVTVvlhDLQPCMVYFLRVTTIRNAEHRSVSEVVSFTTPGCEPDPPLAPTLISRTKNSLSLQWKASND 540
Cdd:COG3401   182 TTSLTVTSTTLVDGGG---DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTE 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  541 NGskISSFLLEWDEGKGEDFKSCYSGRLKQHKLFKLNPSTKYSFRLAAKNDFGC-SNFSETAVFYTSGKTPPAPLPPKLK 619
Cdd:COG3401   259 SD--ATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSGLTAT 336

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  620 EAGIYSLSLEWCAPTNPnpnDTLTYVLEMEEAKSGLGFKPKYNGEDLTCTIRNLQRNTMYKFRIFAYNLEGR-SNPSGEV 698
Cdd:COG3401   337 AVGSSSITLSWTASSDA---DVTGYNVYRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNeSAPSEEV 413

                         410       420       430
                  ....*....|....*....|....*....|
gi 755565528  699 KYTTRPARPGCPNKPYVVGTIHAHQVTIGW 728
Cdd:COG3401   414 SATTASAASGESLTASVDAVPLTDVAGATA 443
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 625-692 1.63e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.53  E-value: 1.63e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755565528    625 SLSLEWCAPTNPNPNDTLTYVLEMEEAKSGLGFKPKYNGEDLTCTIRNLQRNTMYKFRIFAYNLEGRS 692
Cdd:smart00060   16 SVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
PRK08581 PRK08581
amidase domain-containing protein;
235-473 1.38e-04

amidase domain-containing protein;


Pssm-ID: 236304 [Multi-domain]  Cd Length: 619  Bit Score: 46.32  E-value: 1.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  235 TVDTAPGTNTDNSTSDTYSLNTVLNTCTIDSAPRNMADNIPDTNTTDTITSSSAHTPSISTSNATFCSDNNNNITDSSIS 314
Cdd:PRK08581   21 TSPTAYADDPQKDSTAKTTSHDSKKSNDDETSKDTSSKDTDKADNNNTSNQDNNDKKFSTIDSSTSDSNNIIDFIYKNLP 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  315 NYNQVTYDETHKPPDAKSIPSCTSQSASNPSVSENAHNPSSINDGLRPSDVASISENDHEETEANmgagdNKQILGENQK 394
Cdd:PRK08581  101 QTNINQLLTKNKYDDNYSLTTLIQNLFNLNSDISDYEQPRNSEKSTNDSNKNSDSSIKNDTDTQS-----SKQDKADNQK 175

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755565528  395 KSQSSNASLKEHNTEDRTQPGCFNIEKPVVSNIQTRSATVSwTRKSNEKYDiNSSMTHELALSSNGKNGTYKNiYTGNG 473
Cdd:PRK08581  176 APSSNNTKPSTSNKQPNSPKPTQPNQSNSQPASDDTANQKS-SSKDNQSMS-DSALDSILDQYSEDAKKTQKD-YASQS 251
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 715-791 6.86e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.91  E-value: 6.86e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755565528    715 VVGTIHAHQVTIGWDLPKDNGGMN-ISSYSLEVCENSDSanlWKIIYSGTRQ-EFLYDDLQAATTYKLRVFCTSPAGQS 791
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPDDGITGyIVGYRVEYREEGSE---WKEVNVTPSStSYTLTGLKPGTEYEFRVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
624-695 3.53e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 37.78  E-value: 3.53e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755565528   624 YSLSLEWCAPTNPNPNDTlTYVLEMEEAKSGLGFKPKYNGEDL-TCTIRNLQRNTMYKFRIFAYNLEGRSNPS 695
Cdd:pfam00041   14 TSLTVSWTPPPDGNGPIT-GYEVEYRPKNSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1164-1260 5.18e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.48  E-value: 5.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528 1164 PTALKAPKVHPLNNNSCEIKWESLEPIKGDPIVYCLQVTTGKKAN----QIYKGPNTSFSFSNYHANSRYRFKVCAgrry 1239
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDwkevEVTPGSETSYTLTGLKPGTEYEFRVRA---- 76

                          90       100
                  ....*....|....*....|.
gi 755565528 1240 ETSNGlqelWGPYSPSALFST 1260
Cdd:cd00063    77 VNGGG----ESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1130-1235 8.26e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 40.37  E-value: 8.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528 1130 LSEYTEYKFKIQACNEAGEGPESDIYTFTTTKSPPTALKAPKVHPLNNNSCEIKWES--LEPIKGdPIVYcLQVTTGKKA 1207
Cdd:COG3401   199 IEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPvtESDATG-YRVY-RSNSGDGPF 276

                          90       100
                  ....*....|....*....|....*...
gi 755565528 1208 NQIYKGPNTSFSFSNYHANSRYRFKVCA 1235
Cdd:COG3401   277 TKVATVTTTSYTDTGLTNGTTYYYRVTA 304
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
934-1166 6.15e-20

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 95.84  E-value: 6.15e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  934 YEVKGLVPATTYFCRVQAVNIVGVGMFGGTAKVTTPGTVPAMVPVLKEVEskvpakLSSTCIAIRWEEPDchGSPITGYN 1013
Cdd:COG3401   194 DGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATA------DTPGSVTLSWDPVT--ESDATGYR 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528 1014 IEYGDKKVVTVKRI-----TEYVLKDLQPNTTYRIRIQAINHYGL-SPFSPSIRCKTKPLPPEPPQ-LNCVVYGHQSLRL 1086
Cdd:COG3401   266 VYRSNSGDGPFTKVatvttTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSgLTATAVGSSSITL 345

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528 1087 KWGTVSSkktlANFINYNVL-MEDRSGRFSVIYRGPDVT-HKVQKLSEYTEYKFKIQACNEAG-EGPESDIYTFTTTKSP 1163
Cdd:COG3401   346 SWTASSD----ADVTGYNVYrSTSGGGTYTKIAETVTTTsYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAA 421


                  ...
gi 755565528 1164 PTA 1166
Cdd:COG3401   422 SGE 424
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 990-1064 6.83e-17

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 77.15  E-value: 6.83e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  990 LSSTCIAIRWEEPDCHGSPITGYNIEYGDKKVVTVKRI-------TEYVLKDLQPNTTYRIRIQAINHYGLSPFSPSIRC 1062
Cdd:cd00063    12 VTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVevtpgseTSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTV 91


                  ..
gi 755565528 1063 KT 1064
Cdd:cd00063    92 TT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 515-605 3.77e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 72.14  E-value: 3.77e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  515 PDPPLAPTLISRTKNSLSLQWKASNDNGSKISSFLLEWDEGKGEDFKSCYSGRLKQ--HKLFKLNPSTKYSFRLAAKNDF 592
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSEtsYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 755565528  593 GCSNFSETAVFYT 605
Cdd:cd00063    81 GESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
990-1057 7.39e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.13  E-value: 7.39e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755565528   990 LSSTCIAIRWEEPDCHGSPITGYNIEY------GDKKVVTVKR-ITEYVLKDLQPNTTYRIRIQAINHYGLSPFS 1057
Cdd:pfam00041   11 VTSTSLTVSWTPPPDGNGPITGYEVEYrpknsgEPWNEITVPGtTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
890-1142 6.26e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 70.03  E-value: 6.26e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  890 KGPTCVIVSWEIPKCNGAEiiDYRLQWGQVED-SMHLIYTGPCLRYEVKGLVPATTYFCRVQAVNIVGV-GMFGGTAKVT 967
Cdd:COG3401   244 DTPGSVTLSWDPVTESDAT--GYRVYRSNSGDgPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVT 321

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  968 TPGTVPAmVPVLKEVESKVPAKlsstcIAIRWEEPDchGSPITGYNIEYGDKKVVTVKRI------TEYVLKDLQPNTTY 1041
Cdd:COG3401   322 TDLTPPA-APSGLTATAVGSSS-----ITLSWTASS--DADVTGYNVYRSTSGGGTYTKIaetvttTSYTDTGLTPGTTY 393

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528 1042 RIRIQAINHYGL-SPFSPSIRCKTKPLPPEPPQLNCVVYGHQSLRLKWGTVSSKKTLANFINYNVLMEDRSGRFSVIYRG 1120
Cdd:COG3401   394 YYKVTAVDAAGNeSAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTT 473

                         250       260
                  ....*....|....*....|..
gi 755565528 1121 PDVTHKVQKLSEYTEYKFKIQA 1142
Cdd:COG3401   474 SSTVTATTTDTTTANLSVTTGS 495
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 991-1054 8.16e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 62.25  E-value: 8.16e-12
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755565528    991 SSTCIAIRWEEP--DCHGSPITGYNIEYGD-----KKVVTVKRITEYVLKDLQPNTTYRIRIQAINHYGLS 1054
Cdd:smart00060   13 TSTSVTLSWEPPpdDGITGYIVGYRVEYREegsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
921-1186 2.14e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 68.49  E-value: 2.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  921 DSMHLIYTGPCLRYEVKGLVPATTYFCRVQAVNIVGVGMFGGTAKVTTPGTVPAMVPVLKEVESKVPAKLSStciAIRWE 1000
Cdd:COG3401    88 PPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTT---ASSVA 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528 1001 EPDCHGSPITGYNIEYGDKKVVTVKRITEYVLKDLQPNTTYRIRIQAINHYGLSPFSPSIRCKTKPLPPEPPQ-LNCVVY 1079
Cdd:COG3401   165 GAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTgLTATAD 244

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528 1080 GHQSLRLKWgtvsSKKTLANFINYNVL-MEDRSGRFSVIYRGPDVTHKVQKLSEYTEYKFKIQACNEAG-EGPESDIYTF 1157
Cdd:COG3401   245 TPGSVTLSW----DPVTESDATGYRVYrSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSV 320

                         250       260
                  ....*....|....*....|....*....
gi 755565528 1158 TTTKSPPTALKAPKVHPLNNNSCEIKWES 1186
Cdd:COG3401   321 TTDLTPPAAPSGLTATAVGSSSITLSWTA 349
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 879-968 2.19e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.66  E-value: 2.19e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  879 PSQCGTPVLTCKGPTCVIVSWEIPKCNGAEIIDYRLQWGQVEDSMHLIYTGPC---LRYEVKGLVPATTYFCRVQAVNIV 955
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPgseTSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 755565528  956 GVGMFGGTAKVTT 968
Cdd:cd00063    81 GESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
516-598 1.06e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 56.27  E-value: 1.06e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528   516 DPPLAPTLISRTKNSLSLQWKASNDNGSKISSFLLE-WDEGKGEDFKSCY-SGRLKQHKLFKLNPSTKYSFRLAAKNDFG 593
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEyRPKNSGEPWNEITvPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 755565528   594 CSNFS 598
Cdd:pfam00041   81 EGPPS 85
fn3 pfam00041
Fibronectin type III domain;
891-960 2.68e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 2.68e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755565528   891 GPTCVIVSWEIPKCNGAEIIDYRLQWGQV---EDSMHLIYTGPCLRYEVKGLVPATTYFCRVQAVNIVGVGMF 960
Cdd:pfam00041   12 TSTSLTVSWTPPPDGNGPITGYEVEYRPKnsgEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1068-1159 3.02e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.20  E-value: 3.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528 1068 PPEPPQLNCVVYGHQSLRLKWgtVSSKKTLANFINYNVLMEDRSGRFSVIYRGPDVT---HKVQKLSEYTEYKFKIQACN 1144
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSW--TPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSetsYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|....*
gi 755565528 1145 EAGEGPESDIYTFTT 1159
Cdd:cd00063    79 GGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 515-595 5.38e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.16  E-value: 5.38e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528    515 PDPPLAPTLISRTKNSLSLQWKASNDNG--SKISSFLLEWDEGKGEDFKSCYSGRLKQHKLFKLNPSTKYSFRLAAKNDF 592
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 755565528    593 GCS 595
Cdd:smart00060   81 GEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 625-702 6.34e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.42  E-value: 6.34e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755565528  625 SLSLEWCAPTNPNPNDTlTYVLEMEEAKSGLGFK-PKYNGEDLTCTIRNLQRNTMYKFRIFAYNLEGRSNPSGEVKYTT 702
Cdd:cd00063    16 SVTLSWTPPEDDGGPIT-GYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
672-808 6.49e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 60.40  E-value: 6.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  672 NLQRNTMYKFRIFAYNLEGRSNPSGEVKYTTRPARPGCPnKPYVVGTIHAHQVTIGWDlpkDNGGMNISSYSLEVCENSD 751
Cdd:COG3401   198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAP-TGLTATADTPGSVTLSWD---PVTESDATGYRVYRSNSGD 273

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 755565528  752 SAnlWKIIYSGTRQEFLYDDLQAATTYKLRVFCTSPAG-QSRPSDVLTIQTPTLPPES 808
Cdd:COG3401   274 GP--FTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAA 329
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 879-958 6.94e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.16  E-value: 6.94e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528    879 PSQCGTPVLTCKGPTCVIVSWEIPKCNGAE--IIDYRLQWGQVEDS-MHLIYTGPCLRYEVKGLVPATTYFCRVQAVNIV 955
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEwKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 755565528    956 GVG 958
Cdd:smart00060   81 GEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 716-801 6.99e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.42  E-value: 6.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  716 VGTIHAHQVTIGWDLPKDNGGmNISSYSLEVCENSDSAnlWKII--YSGTRQEFLYDDLQAATTYKLRVFCTSPAGQSRP 793
Cdd:cd00063     9 VTDVTSTSVTLSWTPPEDDGG-PITGYVVEYREKGSGD--WKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPP 85


                  ....*...
gi 755565528  794 SDVLTIQT 801
Cdd:cd00063    86 SESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
576-806 3.27e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 58.09  E-value: 3.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  576 LNPSTKYSFRLAAKNDFGCSNFSETAVFYTSGKTPPAPLPPKLKEAGIYSLSLEWcaptNPNPNDTLT-YVLEMEEAKSG 654
Cdd:COG3401   199 IEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSW----DPVTESDATgYRVYRSNSGDG 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  655 lGFKPKYNGEDLTCTIRNLQRNTMYKFRIFAYNLEG-RSNPSGEVKYTTRPARPGCPnkPYVVGTIHAH-QVTIGWDLPK 732
Cdd:COG3401   275 -PFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAP--SGLTATAVGSsSITLSWTASS 351

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755565528  733 DNggmNISSYSLEVCENSDSAnlWKIIYSGTRQEFLYD-DLQAATTYKLRVFCTSPAG-QSRPSDVLTIQTPTLPP 806
Cdd:COG3401   352 DA---DVTGYNVYRSTSGGGT--YTKIAETVTTTSYTDtGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAAS 422
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
229-746 5.51e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 57.32  E-value: 5.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  229 DSLCPYTVDTAPGTNTDNSTSDTYSLNTVLNTCTIDSAPRNMADNIPDT--------NTTDTITSSSAHTPSISTSNATF 300
Cdd:COG3401    38 VYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAapptatglTTLTGSGSVGGATNTGLTSSDEV 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  301 CSD---NNNNITDSSISNYNQVTYDETHKPPDAKSIPSCTSQSASNPSVSENAHNPSSINDGLrPSDVASISENDHEETE 377
Cdd:COG3401   118 PSPavgTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAV-ATTSLTVTSTTLVDGG 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  378 ANMGAGDNKQILGENQKKSQSSNASLKEHNTEDRTQPgcfniEKP---VVSNIQTRSATVSWTRKSNE---KYDInssmt 451
Cdd:COG3401   197 GDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPP-----SAPtglTATADTPGSVTLSWDPVTESdatGYRV----- 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  452 helaLSSNGKNGTYKNIYTGNGVTVVLHDLQPCMVYFLRVTTIRNAEHRSV-SEVVSFTTPGCEPDPPLAPTLISRTKNS 530
Cdd:COG3401   267 ----YRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESApSNVVSVTTDLTPPAAPSGLTATAVGSSS 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  531 LSLQWKASNDNGskISSFLLEWDEGKGEDFKSCYSGRLK-QHKLFKLNPSTKYSFRLAAKNDFGCSNFSETAVFYTSGKT 609
Cdd:COG3401   343 ITLSWTASSDAD--VTGYNVYRSTSGGGTYTKIAETVTTtSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASA 420

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  610 PPAPLPPKLKEAGIYSLSLEWCAPTNPNPNDTLTYVLEMEEAKSGLGFKPKYNGEDLTCTIRNLQRNTMYKFRIFAYNLE 689
Cdd:COG3401   421 ASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGS 500

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 755565528  690 GRSNPSGEVKYttrparPGCPNKPYVVGTIHAHQVTIGWDLPKDNGGMNISSYSLEV 746
Cdd:COG3401   501 GASSVTNSVSV------IGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDLV 551
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
301-728 1.05e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 56.55  E-value: 1.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  301 CSDNNNNITDSSISNYNQVTYDETHKPPDAKSIPSCTSQSASNPSVSENAHNPSSINDGLRPSDVASISENDHEETEANM 380
Cdd:COG3401    23 VNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGS 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  381 GAGDNKQILGENQKKSQSSNASLKEHNTEDRTQPGcFNIEKPVVSNIQTRSATVSWTRKSNEKYDINSSMTHELALSSNG 460
Cdd:COG3401   103 VGGATNTGLTSSDEVPSPAVGTATTATAVAGGAAT-AGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVA 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  461 KNGTYKNIYTGNGVTVvlhDLQPCMVYFLRVTTIRNAEHRSVSEVVSFTTPGCEPDPPLAPTLISRTKNSLSLQWKASND 540
Cdd:COG3401   182 TTSLTVTSTTLVDGGG---DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTE 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  541 NGskISSFLLEWDEGKGEDFKSCYSGRLKQHKLFKLNPSTKYSFRLAAKNDFGC-SNFSETAVFYTSGKTPPAPLPPKLK 619
Cdd:COG3401   259 SD--ATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSGLTAT 336

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  620 EAGIYSLSLEWCAPTNPnpnDTLTYVLEMEEAKSGLGFKPKYNGEDLTCTIRNLQRNTMYKFRIFAYNLEGR-SNPSGEV 698
Cdd:COG3401   337 AVGSSSITLSWTASSDA---DVTGYNVYRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNeSAPSEEV 413

                         410       420       430
                  ....*....|....*....|....*....|
gi 755565528  699 KYTTRPARPGCPNKPYVVGTIHAHQVTIGW 728
Cdd:COG3401   414 SATTASAASGESLTASVDAVPLTDVAGATA 443
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1068-1149 2.12e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.92  E-value: 2.12e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528   1068 PPEPPQLNCVVYGHQSLRLKWGTVSSKKTLANFINYNVLMEDRSGRFSVIYRGPDVT-HKVQKLSEYTEYKFKIQACNEA 1146
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 755565528   1147 GEG 1149
Cdd:smart00060   81 GEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 625-692 1.63e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.53  E-value: 1.63e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755565528    625 SLSLEWCAPTNPNPNDTLTYVLEMEEAKSGLGFKPKYNGEDLTCTIRNLQRNTMYKFRIFAYNLEGRS 692
Cdd:smart00060   16 SVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
PRK08581 PRK08581
amidase domain-containing protein;
235-473 1.38e-04

amidase domain-containing protein;


Pssm-ID: 236304 [Multi-domain]  Cd Length: 619  Bit Score: 46.32  E-value: 1.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  235 TVDTAPGTNTDNSTSDTYSLNTVLNTCTIDSAPRNMADNIPDTNTTDTITSSSAHTPSISTSNATFCSDNNNNITDSSIS 314
Cdd:PRK08581   21 TSPTAYADDPQKDSTAKTTSHDSKKSNDDETSKDTSSKDTDKADNNNTSNQDNNDKKFSTIDSSTSDSNNIIDFIYKNLP 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  315 NYNQVTYDETHKPPDAKSIPSCTSQSASNPSVSENAHNPSSINDGLRPSDVASISENDHEETEANmgagdNKQILGENQK 394
Cdd:PRK08581  101 QTNINQLLTKNKYDDNYSLTTLIQNLFNLNSDISDYEQPRNSEKSTNDSNKNSDSSIKNDTDTQS-----SKQDKADNQK 175

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755565528  395 KSQSSNASLKEHNTEDRTQPGCFNIEKPVVSNIQTRSATVSwTRKSNEKYDiNSSMTHELALSSNGKNGTYKNiYTGNG 473
Cdd:PRK08581  176 APSSNNTKPSTSNKQPNSPKPTQPNQSNSQPASDDTANQKS-SSKDNQSMS-DSALDSILDQYSEDAKKTQKD-YASQS 251
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 715-791 6.86e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.91  E-value: 6.86e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755565528    715 VVGTIHAHQVTIGWDLPKDNGGMN-ISSYSLEVCENSDSanlWKIIYSGTRQ-EFLYDDLQAATTYKLRVFCTSPAGQS 791
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPDDGITGyIVGYRVEYREEGSE---WKEVNVTPSStSYTLTGLKPGTEYEFRVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
1069-1152 9.87e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 39.32  E-value: 9.87e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528  1069 PEPPQLNCVVYGHQSLRLKWGTVSSKKtlANFINYNVLMEDRSG-----RFSViyRGPDVTHKVQKLSEYTEYKFKIQAC 1143
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGN--GPITGYEVEYRPKNSgepwnEITV--PGTTTSVTLTGLKPGTEYEVRVQAV 76


                   ....*....
gi 755565528  1144 NEAGEGPES 1152
Cdd:pfam00041   77 NGGGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
624-695 3.53e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 37.78  E-value: 3.53e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755565528   624 YSLSLEWCAPTNPNPNDTlTYVLEMEEAKSGLGFKPKYNGEDL-TCTIRNLQRNTMYKFRIFAYNLEGRSNPS 695
Cdd:pfam00041   14 TSLTVSWTPPPDGNGPIT-GYEVEYRPKNSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1164-1260 5.18e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.48  E-value: 5.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528 1164 PTALKAPKVHPLNNNSCEIKWESLEPIKGDPIVYCLQVTTGKKAN----QIYKGPNTSFSFSNYHANSRYRFKVCAgrry 1239
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDwkevEVTPGSETSYTLTGLKPGTEYEFRVRA---- 76

                          90       100
                  ....*....|....*....|.
gi 755565528 1240 ETSNGlqelWGPYSPSALFST 1260
Cdd:cd00063    77 VNGGG----ESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1130-1235 8.26e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 40.37  E-value: 8.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755565528 1130 LSEYTEYKFKIQACNEAGEGPESDIYTFTTTKSPPTALKAPKVHPLNNNSCEIKWES--LEPIKGdPIVYcLQVTTGKKA 1207
Cdd:COG3401   199 IEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPvtESDATG-YRVY-RSNSGDGPF 276

                          90       100
                  ....*....|....*....|....*...
gi 755565528 1208 NQIYKGPNTSFSFSNYHANSRYRFKVCA 1235
Cdd:COG3401   277 TKVATVTTTSYTDTGLTNGTTYYYRVTA 304
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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