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Conserved domains on  [gi|767909618|ref|XP_011507965|]
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protoporphyrinogen oxidase isoform X1 [Homo sapiens]

Protein Classification

protoporphyrinogen/coproporphyrinogen oxidase( domain architecture ID 11440906)

protoporphyrinogen/coproporphyrinogen oxidase is a FAD-dependent enzyme that catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX or the oxidation of coproporphyrinogen III to coproporphyrin III, respectively

CATH:  3.50.50.60|3.50.50.60|1.10.3110.10|3.90.660.20
EC:  1.-.-.-
Gene Ontology:  GO:0016491|GO:0009055|GO:0006779|GO:0071949
PubMed:  10944103
SCOP:  4000128|3000055|4000128

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 41-459 5.34e-71

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


:

Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 234.73  E-value: 5.34e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618  41 RTVVVLGGGISGLAASYHLSRAPCppKVVLVESSERLGGWIRSVRGpNGAIFELGPRGI---RPAgalgARTLllacgeq 117
Cdd:COG1232    2 KRVAVIGGGIAGLTAAYRLAKAGH--EVTVLEASDRVGGLIRTVEV-DGFRIDRGPHSFltrDPE----VLEL------- 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 118 VSELGLDSEVLpvrgdHPAAQNRFLYVGGALHALPTGLRGLLRpSPPFSKPLFWAGLRE-LTKPRGKEPDETVHSFAQRR 196
Cdd:COG1232   68 LRELGLGDELV-----WPNTRKSYIYYGGKLHPLPQGPLALLR-SPLLSLAGKLRALLElLAPRRPPGEDESLAEFVRRR 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 197 LGPEVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSillglllgagrtpqpdsaLIRQALAERWSQ------W 270
Cdd:COG1232  142 FGREVYERLVEPLLEGVYAGDPDELSADWAFPRLKRLELEHGS------------------LIKGALALRKGAkagevfG 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 271 SLRGGLEMLPQALETHLtsRGVSVLRGQPVCGLSlQAEGRWKVSLRD-SSLEADHVISAIPASVLSELLPAEAAPLARAL 349
Cdd:COG1232  204 YLRGGLGTLVEALAEAL--EAGEIRLGTRVTAIE-REGGGWRVTTSDgETIEADAVVSATPAPALARLLAPLPPEVAAAL 280

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 350 SAITAVSVAVVNLQYQGAHL-PVQGFGHLVPSSEDPGVLGIVYDSVAFPEQdgSPPGLR-VTVMLGGSWLQTLEAsgcvL 427
Cdd:COG1232  281 AGIPYASVAVVALGFDRPDLpPPDGFGWLVPRDEGVPILAVTFSSNKWPHR--APDGKVlLRLEVGGAGDPELWQ----L 354

                        410       420       430
                 ....*....|....*....|....*....|..
gi 767909618 428 SQELFQQRAQEAAATQLGLKEMPSHCLVHLHK 459
Cdd:COG1232  355 SDEELVALALADLRKLLGIDAEPVDTRVVRWP 386
 
Name Accession Description Interval E-value
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 41-459 5.34e-71

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 234.73  E-value: 5.34e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618  41 RTVVVLGGGISGLAASYHLSRAPCppKVVLVESSERLGGWIRSVRGpNGAIFELGPRGI---RPAgalgARTLllacgeq 117
Cdd:COG1232    2 KRVAVIGGGIAGLTAAYRLAKAGH--EVTVLEASDRVGGLIRTVEV-DGFRIDRGPHSFltrDPE----VLEL------- 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 118 VSELGLDSEVLpvrgdHPAAQNRFLYVGGALHALPTGLRGLLRpSPPFSKPLFWAGLRE-LTKPRGKEPDETVHSFAQRR 196
Cdd:COG1232   68 LRELGLGDELV-----WPNTRKSYIYYGGKLHPLPQGPLALLR-SPLLSLAGKLRALLElLAPRRPPGEDESLAEFVRRR 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 197 LGPEVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSillglllgagrtpqpdsaLIRQALAERWSQ------W 270
Cdd:COG1232  142 FGREVYERLVEPLLEGVYAGDPDELSADWAFPRLKRLELEHGS------------------LIKGALALRKGAkagevfG 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 271 SLRGGLEMLPQALETHLtsRGVSVLRGQPVCGLSlQAEGRWKVSLRD-SSLEADHVISAIPASVLSELLPAEAAPLARAL 349
Cdd:COG1232  204 YLRGGLGTLVEALAEAL--EAGEIRLGTRVTAIE-REGGGWRVTTSDgETIEADAVVSATPAPALARLLAPLPPEVAAAL 280

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 350 SAITAVSVAVVNLQYQGAHL-PVQGFGHLVPSSEDPGVLGIVYDSVAFPEQdgSPPGLR-VTVMLGGSWLQTLEAsgcvL 427
Cdd:COG1232  281 AGIPYASVAVVALGFDRPDLpPPDGFGWLVPRDEGVPILAVTFSSNKWPHR--APDGKVlLRLEVGGAGDPELWQ----L 354

                        410       420       430
                 ....*....|....*....|....*....|..
gi 767909618 428 SQELFQQRAQEAAATQLGLKEMPSHCLVHLHK 459
Cdd:COG1232  355 SDEELVALALADLRKLLGIDAEPVDTRVVRWP 386
proto_IX_ox TIGR00562
protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a ...
 41-415 4.43e-58

protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a precursor of heme and chlorophyll. Bacillus subtilis HemY also has coproporphyrinogen III to coproporphyrin III oxidase activity in a heterologous expression system, although the role for this activity in vivo is unclear. This protein is a flavoprotein and has a beta-alpha-beta dinucleotide binding motif near the amino end. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 213540 [Multi-domain]  Cd Length: 462  Bit Score: 200.83  E-value: 4.43e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618   41 RTVVVLGGGISGLAASYHLS--RAPCPPKVVLVESSERLGGWIRSVRgPNGAIFELGPRGIRPAGAlGARTLllacgeqV 118
Cdd:TIGR00562   3 KHVVIIGGGISGLCAAYYLEkeIPELPVELTLVEASDRVGGKIQTVK-EDGYLIERGPDSFLERKK-SAPDL-------V 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618  119 SELGLDsevlPVRGDHPAAQnRFLYV-GGALHALPTglrgllRPSPPFSKPLFWAG-----LRELTKPRGKEPDETVHSF 192
Cdd:TIGR00562  74 KDLGLE----HVLVSDATGQ-RYVLVnRGKLMPVPT------KIAPFVKTGLFSLGgklraGMDFIRPASPGKDESVEEF 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618  193 AQRRLGPEVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSILLGLLlgagRTPQPDSALIRQALAERWSQW-- 270
Cdd:TIGR00562 143 VRRRFGDEVVENLIEPLLSGIYAGDPSKLSLKSTFPKFYQTEQKHGSLILGMK----KTRNLPQGSGLQLTAKKQGQDfq 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618  271 SLRGGLEMLPQALETHLtsRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIPASVLSELLPAEAAPLARALS 350
Cdd:TIGR00562 219 TLATGLETLPEEIEKRL--KLTKVYKGTKVTKLSHRGSNYTLELDNGVTVETDSVVVTAPHKAAAGLLSELSNSASSHLD 296

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767909618  351 AITAVSVAVVNLQY-----QGAHlpvQGFGHLVPSSEDPGVLGIVYDSVAFPEQdgSPPG-LRVTVMLGGS 415
Cdd:TIGR00562 297 KIHSPPVANVNLGFpegsvDGEL---EGFGFLISRSSKFAILGCIFTSKLFPNR--APPGkTLLTAYIGGA 362
PRK11883 PRK11883
protoporphyrinogen oxidase; Reviewed
 41-399 3.65e-46

protoporphyrinogen oxidase; Reviewed


Pssm-ID: 237009 [Multi-domain]  Cd Length: 451  Bit Score: 168.10  E-value: 3.65e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618  41 RTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRgPNGAIFELGPRGIrpagaLGARTLLLACgeqVSE 120
Cdd:PRK11883   1 KKVAIIGGGITGLSAAYRLHKKGPDADITLLEASDRLGGKIQTVR-KDGFPIELGPESF-----LARKPSAPAL---VKE 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 121 LGLDSEVLpvrgdHPAAQNRFLYVGGALHALPTG-LRGLlrpsPPFSKPLFWAGL----------RELTKPRGK-EPDET 188
Cdd:PRK11883  72 LGLEDELV-----ANTTGQSYIYVNGKLHPIPPGtVMGI----PTSIAPFLFAGLvspigklraaADLRPPRWKpGQDQS 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 189 VHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSIllglLLGAGRTPQPDSALIRQALAerws 268
Cdd:PRK11883 143 VGAFFRRRFGDEVVENLIEPLLSGIYAGDIDTLSLRATFPQLAQAEDKYGSL----LRGMRKALPKEKKKTKGVFG---- 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 269 qwSLRGGLEMLPQALETHLtsRGVSVLRGQPVCGLSLQAEGrWKVSLRDSS-LEADHVISAIPASVLSELLPAEAAplAR 347
Cdd:PRK11883 215 --TLKGGLQSLIEALEEKL--PAGTIHKGTPVTKIDKSGDG-YEIVLSNGGeIEADAVIVAVPHPVLPSLFVAPPA--FA 287

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767909618 348 ALSAITAVSVAVVNLQYQGAHLPV-QGFGHLVPSSEDPGVLGIVYDSVAFPEQ 399
Cdd:PRK11883 288 LFKTIPSTSVATVALAFPESATNLpDGTGFLVARNSDYTITACTWTSKKWPHT 340
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 50-445 6.09e-39

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 148.41  E-value: 6.09e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618   50 ISGLAASYHLSRAPcpPKVVLVESSERLGGWIRSVRGPnGAIFELGPRGIRPAGALgARTLLlacgeqvSELGLDSEVlp 129
Cdd:pfam01593   1 LAGLAAARELLRAG--HDVTVLEARDRVGGRIRTVRDD-GFLIELGAMWFHGAQPP-LLALL-------KELGLEDRL-- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618  130 vRGDHPAAQNRFLYVGG-----ALHALPTGLRGLLRPSPPFS---------KPLFWAGLRELtKPRGKEPDETVHSFAQR 195
Cdd:pfam01593  68 -VLPDPAPFYTVLFAGGrrypgDFRRVPAGWEGLLEFGRLLSipeklrlglAALASDALDEF-DLDDFSLAESLLFLGRR 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618  196 RLGP--------EVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSIllglllgagrtpqpdsalirqalaerw 267
Cdd:pfam01593 146 GPGDvevwdrliDPELFAALPFASGAFAGDPSELSAGLALPLLWALLGEGGSL--------------------------- 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618  268 sqWSLRGGLEMLPQALETHLtsRGVSVLRGQPVCGLSLQAEGRwKVSLRD-SSLEADHVISAIPASVLS--ELLPAEAAP 344
Cdd:pfam01593 199 --LLPRGGLGALPDALAAQL--LGGDVRLNTRVRSIDREGDGV-TVTLTDgEVIEADAVIVTVPLGVLKriLFTPPLPPE 273

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618  345 LARALSAITAVSVAVVNLQYQGAHLPVQgfGHLVPSSEDPGVLGIVYDSVAFPEQDGSPPGLRVTVMLG-GSWLQTLEAs 423
Cdd:pfam01593 274 KARAIRNLGYGPVNKVHLEFDRKFWPDL--GLLGLLSELLTGLGTAFSWLTFPNRAPPGKGLLLLVYVGpGDRARELEG- 350

                         410       420
                  ....*....|....*....|..
gi 767909618  424 gcvLSQELFQQRAQEAAATQLG 445
Cdd:pfam01593 351 ---LSDEELLQAVLRDLRKLFG 369
 
Name Accession Description Interval E-value
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 41-459 5.34e-71

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 234.73  E-value: 5.34e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618  41 RTVVVLGGGISGLAASYHLSRAPCppKVVLVESSERLGGWIRSVRGpNGAIFELGPRGI---RPAgalgARTLllacgeq 117
Cdd:COG1232    2 KRVAVIGGGIAGLTAAYRLAKAGH--EVTVLEASDRVGGLIRTVEV-DGFRIDRGPHSFltrDPE----VLEL------- 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 118 VSELGLDSEVLpvrgdHPAAQNRFLYVGGALHALPTGLRGLLRpSPPFSKPLFWAGLRE-LTKPRGKEPDETVHSFAQRR 196
Cdd:COG1232   68 LRELGLGDELV-----WPNTRKSYIYYGGKLHPLPQGPLALLR-SPLLSLAGKLRALLElLAPRRPPGEDESLAEFVRRR 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 197 LGPEVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSillglllgagrtpqpdsaLIRQALAERWSQ------W 270
Cdd:COG1232  142 FGREVYERLVEPLLEGVYAGDPDELSADWAFPRLKRLELEHGS------------------LIKGALALRKGAkagevfG 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 271 SLRGGLEMLPQALETHLtsRGVSVLRGQPVCGLSlQAEGRWKVSLRD-SSLEADHVISAIPASVLSELLPAEAAPLARAL 349
Cdd:COG1232  204 YLRGGLGTLVEALAEAL--EAGEIRLGTRVTAIE-REGGGWRVTTSDgETIEADAVVSATPAPALARLLAPLPPEVAAAL 280

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 350 SAITAVSVAVVNLQYQGAHL-PVQGFGHLVPSSEDPGVLGIVYDSVAFPEQdgSPPGLR-VTVMLGGSWLQTLEAsgcvL 427
Cdd:COG1232  281 AGIPYASVAVVALGFDRPDLpPPDGFGWLVPRDEGVPILAVTFSSNKWPHR--APDGKVlLRLEVGGAGDPELWQ----L 354

                        410       420       430
                 ....*....|....*....|....*....|..
gi 767909618 428 SQELFQQRAQEAAATQLGLKEMPSHCLVHLHK 459
Cdd:COG1232  355 SDEELVALALADLRKLLGIDAEPVDTRVVRWP 386
proto_IX_ox TIGR00562
protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a ...
 41-415 4.43e-58

protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a precursor of heme and chlorophyll. Bacillus subtilis HemY also has coproporphyrinogen III to coproporphyrin III oxidase activity in a heterologous expression system, although the role for this activity in vivo is unclear. This protein is a flavoprotein and has a beta-alpha-beta dinucleotide binding motif near the amino end. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 213540 [Multi-domain]  Cd Length: 462  Bit Score: 200.83  E-value: 4.43e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618   41 RTVVVLGGGISGLAASYHLS--RAPCPPKVVLVESSERLGGWIRSVRgPNGAIFELGPRGIRPAGAlGARTLllacgeqV 118
Cdd:TIGR00562   3 KHVVIIGGGISGLCAAYYLEkeIPELPVELTLVEASDRVGGKIQTVK-EDGYLIERGPDSFLERKK-SAPDL-------V 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618  119 SELGLDsevlPVRGDHPAAQnRFLYV-GGALHALPTglrgllRPSPPFSKPLFWAG-----LRELTKPRGKEPDETVHSF 192
Cdd:TIGR00562  74 KDLGLE----HVLVSDATGQ-RYVLVnRGKLMPVPT------KIAPFVKTGLFSLGgklraGMDFIRPASPGKDESVEEF 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618  193 AQRRLGPEVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSILLGLLlgagRTPQPDSALIRQALAERWSQW-- 270
Cdd:TIGR00562 143 VRRRFGDEVVENLIEPLLSGIYAGDPSKLSLKSTFPKFYQTEQKHGSLILGMK----KTRNLPQGSGLQLTAKKQGQDfq 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618  271 SLRGGLEMLPQALETHLtsRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIPASVLSELLPAEAAPLARALS 350
Cdd:TIGR00562 219 TLATGLETLPEEIEKRL--KLTKVYKGTKVTKLSHRGSNYTLELDNGVTVETDSVVVTAPHKAAAGLLSELSNSASSHLD 296

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767909618  351 AITAVSVAVVNLQY-----QGAHlpvQGFGHLVPSSEDPGVLGIVYDSVAFPEQdgSPPG-LRVTVMLGGS 415
Cdd:TIGR00562 297 KIHSPPVANVNLGFpegsvDGEL---EGFGFLISRSSKFAILGCIFTSKLFPNR--APPGkTLLTAYIGGA 362
PRK11883 PRK11883
protoporphyrinogen oxidase; Reviewed
 41-399 3.65e-46

protoporphyrinogen oxidase; Reviewed


Pssm-ID: 237009 [Multi-domain]  Cd Length: 451  Bit Score: 168.10  E-value: 3.65e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618  41 RTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRgPNGAIFELGPRGIrpagaLGARTLLLACgeqVSE 120
Cdd:PRK11883   1 KKVAIIGGGITGLSAAYRLHKKGPDADITLLEASDRLGGKIQTVR-KDGFPIELGPESF-----LARKPSAPAL---VKE 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 121 LGLDSEVLpvrgdHPAAQNRFLYVGGALHALPTG-LRGLlrpsPPFSKPLFWAGL----------RELTKPRGK-EPDET 188
Cdd:PRK11883  72 LGLEDELV-----ANTTGQSYIYVNGKLHPIPPGtVMGI----PTSIAPFLFAGLvspigklraaADLRPPRWKpGQDQS 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 189 VHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSIllglLLGAGRTPQPDSALIRQALAerws 268
Cdd:PRK11883 143 VGAFFRRRFGDEVVENLIEPLLSGIYAGDIDTLSLRATFPQLAQAEDKYGSL----LRGMRKALPKEKKKTKGVFG---- 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 269 qwSLRGGLEMLPQALETHLtsRGVSVLRGQPVCGLSLQAEGrWKVSLRDSS-LEADHVISAIPASVLSELLPAEAAplAR 347
Cdd:PRK11883 215 --TLKGGLQSLIEALEEKL--PAGTIHKGTPVTKIDKSGDG-YEIVLSNGGeIEADAVIVAVPHPVLPSLFVAPPA--FA 287

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767909618 348 ALSAITAVSVAVVNLQYQGAHLPV-QGFGHLVPSSEDPGVLGIVYDSVAFPEQ 399
Cdd:PRK11883 288 LFKTIPSTSVATVALAFPESATNLpDGTGFLVARNSDYTITACTWTSKKWPHT 340
PLN02576 PLN02576
protoporphyrinogen oxidase
 40-415 5.37e-44

protoporphyrinogen oxidase


Pssm-ID: 215314 [Multi-domain]  Cd Length: 496  Bit Score: 163.26  E-value: 5.37e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618  40 GRTVVVLGGGISGLAASYHLSRAPCPpKVVLVESSERLGGWIRSVRGpNGAIFELGPRGIRPAGALgartLLLACgeqvs 119
Cdd:PLN02576  12 SKDVAVVGAGVSGLAAAYALASKHGV-NVLVTEARDRVGGNITSVSE-DGFIWEEGPNSFQPSDPE----LTSAV----- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 120 ELGL-DSEVLPVrgdhPAAqNRFLYVGGALHALPTGLRGLlrpspPFSKPLFWAG-LRELTKP----RGKEPD--ETVHS 191
Cdd:PLN02576  81 DSGLrDDLVFPD----PQA-PRYVVWNGKLRPLPSNPIDL-----PTFDLLSAPGkIRAGLGAfgwkRPPPPGreESVGE 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 192 FAQRRLGPEVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSI-----LLGLLLGAGRTPQP-DSALIRQalaE 265
Cdd:PLN02576 151 FVRRHLGDEVFERLIDPFVSGVYAGDPSSLSMKAAFPKLWNLEKRGGSIiggaiKAIQEAKKNPKPEPrDPRLPKP---K 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 266 RWSQWSLRGGLEMLPQALETHLTSRGVSVlrGQPVCGLSLQAEGRWKVSLRD----SSLEADHVISAIPASVLSELLPAE 341
Cdd:PLN02576 228 GQTVGSFRGGLQTLPDALAKRLGKDKVKL--NWKVLSLSKNDDGGYSLTYDTpegkVNVTAKAVVMTAPLYVVSEMLRPK 305

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 342 AAPLARALSAITAVSVAVVNLQY--------QGAHLPVQGFGHLVPSSEDPGVLGIVYDSVAFPeqDGSPPGLRV-TVML 412
Cdd:PLN02576 306 SPAAADALPEFYYPPVAAVTTSYpkeavkreRLIDGPLEGFGQLHPRKQGVKTLGTIYSSSLFP--DRAPEGRVLlLNYI 383


                 ...
gi 767909618 413 GGS 415
Cdd:PLN02576 384 GGS 386
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 50-445 6.09e-39

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 148.41  E-value: 6.09e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618   50 ISGLAASYHLSRAPcpPKVVLVESSERLGGWIRSVRGPnGAIFELGPRGIRPAGALgARTLLlacgeqvSELGLDSEVlp 129
Cdd:pfam01593   1 LAGLAAARELLRAG--HDVTVLEARDRVGGRIRTVRDD-GFLIELGAMWFHGAQPP-LLALL-------KELGLEDRL-- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618  130 vRGDHPAAQNRFLYVGG-----ALHALPTGLRGLLRPSPPFS---------KPLFWAGLRELtKPRGKEPDETVHSFAQR 195
Cdd:pfam01593  68 -VLPDPAPFYTVLFAGGrrypgDFRRVPAGWEGLLEFGRLLSipeklrlglAALASDALDEF-DLDDFSLAESLLFLGRR 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618  196 RLGP--------EVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSIllglllgagrtpqpdsalirqalaerw 267
Cdd:pfam01593 146 GPGDvevwdrliDPELFAALPFASGAFAGDPSELSAGLALPLLWALLGEGGSL--------------------------- 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618  268 sqWSLRGGLEMLPQALETHLtsRGVSVLRGQPVCGLSLQAEGRwKVSLRD-SSLEADHVISAIPASVLS--ELLPAEAAP 344
Cdd:pfam01593 199 --LLPRGGLGALPDALAAQL--LGGDVRLNTRVRSIDREGDGV-TVTLTDgEVIEADAVIVTVPLGVLKriLFTPPLPPE 273

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618  345 LARALSAITAVSVAVVNLQYQGAHLPVQgfGHLVPSSEDPGVLGIVYDSVAFPEQDGSPPGLRVTVMLG-GSWLQTLEAs 423
Cdd:pfam01593 274 KARAIRNLGYGPVNKVHLEFDRKFWPDL--GLLGLLSELLTGLGTAFSWLTFPNRAPPGKGLLLLVYVGpGDRARELEG- 350

                         410       420
                  ....*....|....*....|..
gi 767909618  424 gcvLSQELFQQRAQEAAATQLG 445
Cdd:pfam01593 351 ---LSDEELLQAVLRDLRKLFG 369
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
38-364 1.87e-23

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 103.08  E-value: 1.87e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618  38 RMGRTVVVLGGGISGLAASYHLSRAPCppKVVLVESSERLGGWIRSVRGP-NGAIFELGPRGIRPagalgARTLLLAcge 116
Cdd:COG1231    5 ARGKDVVIVGAGLAGLAAARELRKAGL--DVTVLEARDRVGGRVWTLRFGdDGLYAELGAMRIPP-----SHTNLLA--- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 117 QVSELGLDSEVLPvrgdhPAAQNRFLYVGGALHALPTGLRGLLRPSPPFSK---PLFwAGLRELTKPRGKEPDETVHSFA 193
Cdd:COG1231   75 LARELGLPLEPFP-----NENGNALLYLGGKRVRAGEIAADLRGVAELLAKllrALA-AALDPWAHPAAELDRESLAEWL 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 194 QRRLGPEVASLAMDSLCRGVFAGNSRELSIrscfpslfqaeqthrsillglllgagrtpqpdSALIRQALAERWS--QWS 271
Cdd:COG1231  149 RRNGASPSARRLLGLLGAGEYGADPDELSL--------------------------------LDLLRYAASAGGGaqQFR 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 272 LRGGLEMLPQALETHLTSRgvsVLRGQPVCGLSlQAEGRWKVSLRD-SSLEADHVISAIPASVLS--ELLPAEAAPLARA 348
Cdd:COG1231  197 IVGGMDQLPRALAAELGDR---IRLGAPVTRIR-QDGDGVTVTTDDgGTVRADAVIVTVPPSVLRriEFDPPLPAAKRAA 272

                        330
                 ....*....|....*.
gi 767909618 349 LSAITAVSVAVVNLQY 364
Cdd:COG1231  273 IQRLPYGAAIKVFLQF 288
COG3349 COG3349
Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function ...
 39-374 5.69e-16

Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function prediction only];


Pssm-ID: 442577 [Multi-domain]  Cd Length: 445  Bit Score: 80.28  E-value: 5.69e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618  39 MGRTVVVLGGGISGLAASYHLSRAPCPpkVVLVESSERLGGWIRSVRGPN-GAIFELGPRgirpagalgartLLLACGEQ 117
Cdd:COG3349    2 MPPRVVVVGGGLAGLAAAVELAEAGFR--VTLLEARPRLGGRARSFPDPDtGLPIDNGQH------------VLLGCYRN 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 118 VSELgldSEVLPVRgDHPAAQNRFLYvggalhALPTGLRGLLRPSPPfskPLFWAGLRELTKPRGKEPDEtvhsfaqrRL 197
Cdd:COG3349   68 TLDL---LRRIGAA-DNLVGPEPLQF------PLPGGRRWTLRAPRL---PAPLHLLRALLRAPGLSLAD--------RL 126

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 198 GpeVASLAMDSLCRGVFAGnsRELSIRSCFPSLFQAEQTHRSILLGLLLGAGRTPqPDSA-------LIRQALA---ERW 267
Cdd:COG3349  127 A--LLRLLTACRERRWREL--DDISVADWLRRHGQSPRLIRRLWEPLLLAALNTP-PEQAsarlaltVLRETLLagpAAS 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 268 SQWSLRGGL-EMLPQALETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRD-SSLEADHVISAIPASVLSELLPA-EAAP 344
Cdd:COG3349  202 DLLVPRGPLsELFVDPALAYLEARGGEVRLGTRVRALEFDGGRVTGLVLADgETVPADAVVLAVPPEVAARLLPElARLP 281

                        330       340       350
                 ....*....|....*....|....*....|....
gi 767909618 345 LARALSAITAVSVAVVNLQYQG----AHLPVQGF 374
Cdd:COG3349  282 ELGLLAPLEYSPIVNVHLWLDRpvtlGPPPFAGL 315
PRK12416 PRK12416
protoporphyrinogen oxidase; Provisional
 41-383 2.92e-15

protoporphyrinogen oxidase; Provisional


Pssm-ID: 183516  Cd Length: 463  Bit Score: 78.33  E-value: 2.92e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618  41 RTVVVLGGGISGLAASYHLSRAP----CPPKVVLVESSERLGGWIRSVRGpNGAIFELGprgirpAGALGARTLLLAcgE 116
Cdd:PRK12416   2 KTVVVIGGGITGLSTMFYLEKLKkdynIDLNLILVEKEEYLGGKIHSVEE-KDFIMESG------ADSIVARNEHVM--P 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 117 QVSELGLDSEVLpvrgdHPAAQNRFLYVGGALH--------ALPTGLRGLLRPSPPFSKPLFWAGLRELTKPRGKEPDET 188
Cdd:PRK12416  73 LVKDLNLEEEMV-----YNETGISYIYSDNTLHpipsdtifGIPMSVESLFSSTLVSTKGKIVALKDFITKNKEFTKDTS 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 189 VHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSILlglllgagrtpqpdsalirQALAERWS 268
Cdd:PRK12416 148 LALFLESFLGKELVERQIAPVLSGVYSGKLNELTMASTLPYLLDYKNKYGSII-------------------KGFEENKK 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 269 QW---------SLRGGLEMLPQALETHLTSrgVSVLRGQPVCGLSLQAEgRWKVSLRD-SSLEADHVISAIPASVLSELL 338
Cdd:PRK12416 209 QFqsagnkkfvSFKGGLSTIIDRLEEVLTE--TVVKKGAVTTAVSKQGD-RYEISFANhESIQADYVVLAAPHDIAETLL 285

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 767909618 339 paEAAPLARALSAITAVSVAVVNLQYQ--GAHLPVQGFGHLVPSSED 383
Cdd:PRK12416 286 --QSNELNEQFHTFKNSSLISIYLGFDilDEQLPADGTGFIVTENSD 330
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 39-362 1.21e-11

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 67.18  E-value: 1.21e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618  39 MGRTVVVLGGGISGLAASYHLSRAPCppKVVLVESSERLGGWIRSVRGPnGAIFELGPRGIRPAGALgartlllacgEQV 118
Cdd:COG1233    2 MMYDVVVIGAGIGGLAAAALLARAGY--RVTVLEKNDTPGGRARTFERP-GFRFDVGPSVLTMPGVL----------ERL 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 119 -SELGLDSEV----LPVRGDHPAAQNRFLYV------------------GGALHAL--------PTGLRGLL-RPSPPFS 166
Cdd:COG1233   69 fRELGLEDYLelvpLDPAYRVPFPDGRALDLprdlertaaelerlfpgdAEAYRRFlaelrrlyDALLEDLLyRPLLSLR 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 167 KPLFWAGLRELtkprGKEPDETVHSFAQRRLGPEVAslamdslcRGVFAgnsrelsirscFPSLFqaeqthrsillglll 246
Cdd:COG1233  149 DLLRPLALARL----LRLLLRSLRDLLRRYFKDPRL--------RALLA-----------GQALY--------------- 190

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 247 gAGRTPQPDSAL--IRQALAERWSQWSLRGGLEMLPQALETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRD-SSLEAD 323
Cdd:COG1233  191 -LGLSPDRTPALyaLIAYLEYAGGVWYPKGGMGALADALARLAEELGGEIRTGAEVERILVEGGRATGVRLADgEEIRAD 269

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 767909618 324 HVISAI-PASVLSELLPAEAAP--LARALSAIT-AVSVAVVNL 362
Cdd:COG1233  270 AVVSNAdPAHTYLRLLGEEALParYRRRLERFRySPSAFKLYL 312
PRK07233 PRK07233
hypothetical protein; Provisional
 42-360 3.32e-10

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 62.21  E-value: 3.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618  42 TVVVLGGGISGLAASYHLSRAPCppKVVLVESSERLGGWirsvrgpnGAIFELGprgirpaG----------ALGARTLL 111
Cdd:PRK07233   1 KIAIVGGGIAGLAAAYRLAKRGH--EVTVFEADDQLGGL--------AASFEFG-------GlpierfyhhiFKSDEALL 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 112 lacgEQVSELGLDSEVLPVRGdhpaaQNRFlYVGGALHALPTGLRgLLRpSPPFS--------KPLFWAGLRELTKPRGK 183
Cdd:PRK07233  64 ----ELLDELGLEDKLRWRET-----KTGY-YVDGKLYPLGTPLE-LLR-FPHLSlidkfrlgLLTLLARRIKDWRALDK 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 184 EPDETvhsFAQRRLGPEVASLAMDSLCRGVFAGNSRELS---------IRScfpslfqaeqthRSillglllgagrtpqp 254
Cdd:PRK07233 132 VPAEE---WLRRWSGEGVYEVFWEPLLESKFGDYADDVSaawlwsrikRRG------------NR--------------- 181

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 255 DSALIRQALAerwsqwSLRGGLEMLPQALETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIPASVL 334
Cdd:PRK07233 182 RYSLFGEKLG------YLEGGFATLIDALAEAIEARGGEIRLGTPVTSVVIDGGGVTGVEVDGEEEDFDAVISTAPPPIL 255

                        330       340
                 ....*....|....*....|....*.
gi 767909618 335 SELLPAEAAPLARALSAITAVSVAVV 360
Cdd:PRK07233 256 ARLVPDLPADVLARLRRIDYQGVVCM 281
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
45-111 2.12e-09

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 53.69  E-value: 2.12e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767909618   45 VLGGGISGLAASYHLSRAPCppKVVLVESSERLGGWIRSVRgPNGAIFELGPRGIRPAGALGARTLL 111
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGF--RVLVLEKRDRLGGNAYSYR-VPGYVFDYGAHIFHGSDEPNVRDLL 64
PLN02268 PLN02268
probable polyamine oxidase
 42-81 1.08e-05

probable polyamine oxidase


Pssm-ID: 177909 [Multi-domain]  Cd Length: 435  Bit Score: 48.15  E-value: 1.08e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 767909618  42 TVVVLGGGISGLAASYHLSRAPCppKVVLVESSERLGGWI 81
Cdd:PLN02268   2 SVIVIGGGIAGIAAARALHDASF--KVTLLESRDRIGGRV 39
PRK07208 PRK07208
hypothetical protein; Provisional
 278-351 4.69e-05

hypothetical protein; Provisional


Pssm-ID: 235967 [Multi-domain]  Cd Length: 479  Bit Score: 46.04  E-value: 4.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618 278 MLPQALETHLTSRGVSVLRGQPVCGLSLQAEGR-WKVSLRDS-----SLEADHVISAIPASVLSELLPAEAAPLARALSA 351
Cdd:PRK07208 219 QLWETAAEKLEALGGKVVLNAKVVGLHHDGDGRiAVVVVNDTdgteeTVTADQVISSMPLRELVAALDPPPPPEVRAAAA 298
Ppro0129 COG2907
Predicted flavin-containing amine oxidase [General function prediction only];
39-79 5.02e-05

Predicted flavin-containing amine oxidase [General function prediction only];


Pssm-ID: 442151 [Multi-domain]  Cd Length: 423  Bit Score: 45.88  E-value: 5.02e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 767909618  39 MGRTVVVLGGGISGLAASYHLSRApcpPKVVLVESSERLGG 79
Cdd:COG2907    2 ARMRIAVIGSGISGLTAAWLLSRR---HDVTLFEANDRLGG 39
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 43-80 1.21e-04

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 44.47  E-value: 1.21e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 767909618  43 VVVLGGGISGLAASYHLSRApCPPkVVLVESSERLGG-W 80
Cdd:COG2072    9 VVVIGAGQAGLAAAYHLRRA-GID-FVVLEKADDVGGtW 45
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
41-82 1.33e-04

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 44.85  E-value: 1.33e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 767909618  41 RTVVVLGGGISGLAASYHLSRAPCppKVVLVESSERLGGWIR 82
Cdd:COG1148  141 KRALVIGGGIAGMTAALELAEQGY--EVYLVEKEPELGGRAA 180
HpnE TIGR03467
squalene-associated FAD-dependent desaturase; The sequences in this family are members of the ...
 287-367 1.62e-04

squalene-associated FAD-dependent desaturase; The sequences in this family are members of the pfam01593 superfamily of flavin-containing amine oxidases which include the phytoene desaturases. These sequences also include a FAD-dependent oxidoreductase domain, pfam01266. The genes of the family modeled here are generally in the same locus with genes involved in the biosynthesis and elaboration of squalene, the condensation product of the polyisoprenoid farnesyl pyrophosphate. This gene and its association with hopene biosynthesis in Zymomonas mobilis has been noted in the literature where the gene symbol hpnE was assigned. This gene is also found in contexts where the downstream conversion of squalene to hopenes is not evidence. The precise nature of the reaction catalyzed by this enzyme is unknown at this time.


Pssm-ID: 274593 [Multi-domain]  Cd Length: 419  Bit Score: 44.28  E-value: 1.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909618  287 LTSRGVSVLRGQPVCGLSLQAEG-RWKVSLRDSSLEADHVISAIPASVLSELLPAEAAPlaRALSAITAVSVAVVNLQYQ 365
Cdd:TIGR03467 207 LDSRGGEVRLGTRVRSIEANAGGiRALVRSGGETLPADAVVLAVPPRHAASLLPGEDLG--ALLTALGYSPITTVHLRLD 284


                  ..
gi 767909618  366 GA 367
Cdd:TIGR03467 285 RA 286
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 43-83 9.61e-04

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 41.61  E-value: 9.61e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 767909618   43 VVVLGGGISGLAASYHLSRApcPPKVVLVESSERLG--------GWIRS 83
Cdd:pfam01266   2 VVVIGGGIVGLSTAYELARR--GLSVTLLERGDDPGsgasgrnaGLIHP 48
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
43-100 1.22e-03

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 41.43  E-value: 1.22e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767909618  43 VVVLGGGISGLAASYHLSRAPCppKVVLVE-------SSERLGGWIRSVRGP--NGAIFELGPRGIR 100
Cdd:COG0665    5 VVVIGGGIAGLSTAYHLARRGL--DVTVLErgrpgsgASGRNAGQLRPGLAAlaDRALVRLAREALD 69
PRK12771 PRK12771
putative glutamate synthase (NADPH) small subunit; Provisional
 30-82 2.63e-03

putative glutamate synthase (NADPH) small subunit; Provisional


Pssm-ID: 237198 [Multi-domain]  Cd Length: 564  Bit Score: 40.63  E-value: 2.63e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767909618  30 VTLAGPGFRMGRTVVVLGGGISGLAASYHLSRApcPPKVVLVESSERLGGWIR 82
Cdd:PRK12771 127 WKFPAPAPDTGKRVAVIGGGPAGLSAAYHLRRM--GHAVTIFEAGPKLGGMMR 177
YdhS COG4529
Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];
41-78 4.44e-03

Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];


Pssm-ID: 443597 [Multi-domain]  Cd Length: 466  Bit Score: 39.55  E-value: 4.44e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 767909618  41 RTVVVLGGGISGLAASYHLSR-APCPPKVVLVESSERLG 78
Cdd:COG4529    6 KRIAIIGGGASGTALAIHLLRrAPEPLRITLFEPRPELG 44
PRK04965 PRK04965
NADH:flavorubredoxin reductase NorW;
278-329 7.78e-03

NADH:flavorubredoxin reductase NorW;


Pssm-ID: 179902 [Multi-domain]  Cd Length: 377  Bit Score: 38.74  E-value: 7.78e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909618 278 MLP----QALETHLTSRGVSVLRGQPVCGLSLQAEGrWKVSLRDS-SLEADHVISAI 329
Cdd:PRK04965 180 LMPpevsSRLQHRLTEMGVHLLLKSQLQGLEKTDSG-IRATLDSGrSIEVDAVIAAA 235
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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