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Conserved domains on  [gi|767909689|ref|XP_011507992|]
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G patch domain-containing protein 2 isoform X2 [Homo sapiens]

Protein Classification

G patch domain-containing protein( domain architecture ID 10481954)

G patch domain-containing protein similar to Saccharomyces cerevisiae protein PXR1 that is involved in rRNA-processing at A0, A1 and A2 sites through its action in U18 and U24 snoRNA 3'-end final trimming, and pre-mRNA-splicing factor SPP382 that is involved in pre-mRNA splicing and spliceosome disassembly

Gene Ontology:  GO:0003676
PubMed:  10470032|33857358

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 454-495 6.02e-15

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


:

Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 68.69  E-value: 6.02e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 767909689  454 NNIGNRMLQNMGWTPGSGLGRDGKGISEPIQAMQRPKGLGLG 495
Cdd:pfam01585   2 SNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLG 43
 
Name Accession Description Interval E-value
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 454-495 6.02e-15

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 68.69  E-value: 6.02e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 767909689  454 NNIGNRMLQNMGWTPGSGLGRDGKGISEPIQAMQRPKGLGLG 495
Cdd:pfam01585   2 SNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLG 43
G_patch smart00443
glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in ...
 451-496 5.37e-13

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.


Pssm-ID: 197727 [Multi-domain]  Cd Length: 47  Bit Score: 63.33  E-value: 5.37e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 767909689   451 ILENNIGNRMLQNMGWTPGSGLGRDGKGISEPIQAMQRPKGLGLGF 496
Cdd:smart00443   1 ISTSNIGAKLLRKMGWKEGQGLGKNEQGIVEPISAEIKKDRKGLGA 46
 
Name Accession Description Interval E-value
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 454-495 6.02e-15

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 68.69  E-value: 6.02e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 767909689  454 NNIGNRMLQNMGWTPGSGLGRDGKGISEPIQAMQRPKGLGLG 495
Cdd:pfam01585   2 SNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLG 43
G_patch smart00443
glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in ...
 451-496 5.37e-13

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.


Pssm-ID: 197727 [Multi-domain]  Cd Length: 47  Bit Score: 63.33  E-value: 5.37e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 767909689   451 ILENNIGNRMLQNMGWTPGSGLGRDGKGISEPIQAMQRPKGLGLGF 496
Cdd:smart00443   1 ISTSNIGAKLLRKMGWKEGQGLGKNEQGIVEPISAEIKKDRKGLGA 46
G-patch_2 pfam12656
G-patch domain; Yeast Spp2, a G-patch protein and spliceosome component, interacts with the ...
 455-496 1.52e-08

G-patch domain; Yeast Spp2, a G-patch protein and spliceosome component, interacts with the ATP-dependent DExH-box splicing factor Prp2. As this interaction involves the G-patch sequence in Spp2 and is required for the recruitment of Prp2 to the spliceosome before the first catalytic step of splicing, it is proposed that Spp2 might be an accessory factor that confers spliceosome specificity on Prp2.


Pssm-ID: 432700 [Multi-domain]  Cd Length: 61  Bit Score: 51.12  E-value: 1.52e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 767909689  455 NIGNRMLQNMGWTPGSGLGRDGKGISEPIQAMQRPKGLGLGF 496
Cdd:pfam12656  16 EFGAAMLRGMGWKPGQGIGKNKKGDVKPKEYKRRPGGLGLGA 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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