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Conserved domains on  [gi|767910076|ref|XP_011508142|]
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leucine-rich repeat-containing G-protein coupled receptor 6 isoform X7 [Homo sapiens]

Protein Classification

LRR and 7tmA_LGR6 domain-containing protein( domain architecture ID 11471190)

protein containing domains LRR, LRR_8, and 7tmA_LGR6

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7tmA_LGR6 cd15362
leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane ...
 447-719 1.44e-165

leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs; The leucine-rich repeat containing G-protein coupled receptor LGR5, together with its family members LGR4 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR5 serves as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 is a marker for multipotent stem cells in the hair follicle that generate all skin cell lineages. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


:

Pssm-ID: 320484  Cd Length: 276  Bit Score: 481.60  E-value: 1.44e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 447 WGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVpLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 526
Cdd:cd15362    1 WVVRLGVWAIVLVSVLCNGLVILTVFASPGY-LSPVKFVIGSIAGANLLTGICTGTLALVDALTFGQFAKYGARWETGLG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 527 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYA 606
Cdd:cd15362   80 CRATGFLSVFASEASILLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAAALCCLALSLTAAALPLFSVGEYGASPLCLPSP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 607 PPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 686
Cdd:cd15362  160 LPDGKPSTLGFTVALIMMNTLCFLVITGTYIKLYCDLLKGEFDAIWDCAMIKHVAWLIFTNCLLYCPVAFLTFSSLLNLF 239

                        250       260       270
                 ....*....|....*....|....*....|...
gi 767910076 687 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 719
Cdd:cd15362  240 PISPEVIKSVLLVVLPLPACLNPLLYLLFNPHF 272
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
33-350 9.50e-35

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 137.76  E-value: 9.50e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076  33 NNLTELQPGLFHHLRFLEELRLSGNhlshipgQAFSGLYSLKILMLQNNQLGGIPAEaLWELPSLQSLHLHNNRIQHLGT 112
Cdd:COG4886   82 LSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPE 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 113 hSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEkafmgnpllqtihfydnpiqfvgrsafqylpkl 192
Cdd:COG4886  154 -PLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE--------------------------------- 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 193 htlslngamdiqefpDLKGTTSLEILTLTRAGIRLLPSGMcQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIW 272
Cdd:COG4886  200 ---------------PLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLT 263

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767910076 273 EIgaDTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSF 350
Cdd:COG4886  264 DL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339
LRR_8 pfam13855
Leucine rich repeat;
143-199 1.04e-06

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 1.04e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767910076  143 RLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNG 199
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSG 58
 
Name Accession Description Interval E-value
7tmA_LGR6 cd15362
leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane ...
 447-719 1.44e-165

leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs; The leucine-rich repeat containing G-protein coupled receptor LGR5, together with its family members LGR4 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR5 serves as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 is a marker for multipotent stem cells in the hair follicle that generate all skin cell lineages. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320484  Cd Length: 276  Bit Score: 481.60  E-value: 1.44e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 447 WGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVpLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 526
Cdd:cd15362    1 WVVRLGVWAIVLVSVLCNGLVILTVFASPGY-LSPVKFVIGSIAGANLLTGICTGTLALVDALTFGQFAKYGARWETGLG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 527 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYA 606
Cdd:cd15362   80 CRATGFLSVFASEASILLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAAALCCLALSLTAAALPLFSVGEYGASPLCLPSP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 607 PPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 686
Cdd:cd15362  160 LPDGKPSTLGFTVALIMMNTLCFLVITGTYIKLYCDLLKGEFDAIWDCAMIKHVAWLIFTNCLLYCPVAFLTFSSLLNLF 239

                        250       260       270
                 ....*....|....*....|....*....|...
gi 767910076 687 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 719
Cdd:cd15362  240 PISPEVIKSVLLVVLPLPACLNPLLYLLFNPHF 272
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
33-350 9.50e-35

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 137.76  E-value: 9.50e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076  33 NNLTELQPGLFHHLRFLEELRLSGNhlshipgQAFSGLYSLKILMLQNNQLGGIPAEaLWELPSLQSLHLHNNRIQHLGT 112
Cdd:COG4886   82 LSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPE 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 113 hSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEkafmgnpllqtihfydnpiqfvgrsafqylpkl 192
Cdd:COG4886  154 -PLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE--------------------------------- 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 193 htlslngamdiqefpDLKGTTSLEILTLTRAGIRLLPSGMcQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIW 272
Cdd:COG4886  200 ---------------PLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLT 263

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767910076 273 EIgaDTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSF 350
Cdd:COG4886  264 DL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 29-326 1.53e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 91.06  E-value: 1.53e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076  29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLS-HIPGqAFSGLYSLKILMLQNNQL-GGIPAEalwelpslqsLHLHNN- 105
Cdd:PLN00113 290 DLSDNSLSGEIPELVIQLQNLEILHLFSNNFTgKIPV-ALTSLPRLQVLQLWSNKFsGEIPKN----------LGKHNNl 358

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 106 RIQHLGTHSF-----EGL---HNLETLDLNYNKLQ-EFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDN 176
Cdd:PLN00113 359 TVLDLSTNNLtgeipEGLcssGNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNN 438

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 177 PIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIR-LLPSGMcQQLPRLRVLELSHNQIE-ELPS 254
Cdd:PLN00113 439 NLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKL-GSLSELMQLKLSENKLSgEIPD 517

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767910076 255 -LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQL-TTLPLAG 326
Cdd:PLN00113 518 eLSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLhGSLPSTG 591
LRR_8 pfam13855
Leucine rich repeat;
49-107 1.47e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 68.71  E-value: 1.47e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767910076   49 LEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLHLHNNRI 107
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 52-323 2.46e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 72.90  E-value: 2.46e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076  52 LRLSGNHLSHIPGqaFSGLYSLKILMLQNNQLGGIpaEALWELPSLQSLHLHNNRIQHLGthSFEGLHNLETLDLNYNKl 131
Cdd:cd21340    7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNR- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 132 qefpvaIRTLGRLQELgfhnnnikaipekafmgnPLLQTIHFyDNpiqfvgrsafQYLPKlhtlslngamdiqefpdlkg 211
Cdd:cd21340   80 ------ISVVEGLENL------------------TNLEELHI-EN----------QRLPP-------------------- 104

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 212 TTSLEILTLTRAGIRllpsgmcqqlPRLRVLELSHNQIEELPSLhrcqkleeiglqhnriweigadtfSQLSSLQALDLS 291
Cdd:cd21340  105 GEKLTFDPRSLAALS----------NSLRVLNISGNNIDSLEPL------------------------APLRNLEQLDAS 150

                        250       260       270
                 ....*....|....*....|....*....|....
gi 767910076 292 WNAIRSIHP--EAFSTLHSLVKLDLTDNQLTTLP 323
Cdd:cd21340  151 NNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
143-199 1.04e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 1.04e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767910076  143 RLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNG 199
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSG 58
LRR smart00370
Leucine-rich repeats, outliers;
282-304 4.86e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 4.86e-03
                           10        20
                   ....*....|....*....|...
gi 767910076   282 LSSLQALDLSWNAIRSIHPEAFS 304
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQ 23
 
Name Accession Description Interval E-value
7tmA_LGR6 cd15362
leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane ...
 447-719 1.44e-165

leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs; The leucine-rich repeat containing G-protein coupled receptor LGR5, together with its family members LGR4 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR5 serves as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 is a marker for multipotent stem cells in the hair follicle that generate all skin cell lineages. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320484  Cd Length: 276  Bit Score: 481.60  E-value: 1.44e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 447 WGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVpLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 526
Cdd:cd15362    1 WVVRLGVWAIVLVSVLCNGLVILTVFASPGY-LSPVKFVIGSIAGANLLTGICTGTLALVDALTFGQFAKYGARWETGLG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 527 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYA 606
Cdd:cd15362   80 CRATGFLSVFASEASILLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAAALCCLALSLTAAALPLFSVGEYGASPLCLPSP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 607 PPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 686
Cdd:cd15362  160 LPDGKPSTLGFTVALIMMNTLCFLVITGTYIKLYCDLLKGEFDAIWDCAMIKHVAWLIFTNCLLYCPVAFLTFSSLLNLF 239

                        250       260       270
                 ....*....|....*....|....*....|...
gi 767910076 687 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 719
Cdd:cd15362  240 PISPEVIKSVLLVVLPLPACLNPLLYLLFNPHF 272
7tmA_LRR_GPR cd15138
orphan leucine-rich repeat-containing G protein-coupled receptors, member of the class A ...
 447-719 1.91e-147

orphan leucine-rich repeat-containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4), 5 (LGR5), and 6 (LGR6). These receptors contain a subfamily of receptors related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The RSPO proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320266  Cd Length: 274  Bit Score: 435.05  E-value: 1.91e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 447 WGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPlPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 526
Cdd:cd15138    1 WMIRLTVWFIFLLALFCNLLVILTVFASCTSL-PPSKLFIGLIAVSNLLTGISTGILAFVDAVTFGRFAEFGAWWETGSG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 527 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYA 606
Cdd:cd15138   80 CKVAGFLAVFSSESSVFLLTLAAVERSLSVKDIMKNGKSNHLKSFRVAALLCFLLATVAAAFPLFHRGEYGASPLCLPFP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 607 PpeGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 686
Cdd:cd15138  160 T--GEPPSLGFTVALVLLNSLCFLLMAVAYTKLYCNLEKGDLEENWDCSMVKHVAWLIFTNCILFCPVAFLSFASLITLI 237

                        250       260       270
                 ....*....|....*....|....*....|...
gi 767910076 687 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 719
Cdd:cd15138  238 SISPEIMKSVLLVVFPLPACLNPLLYVLFNPHF 270
7tmA_LGR5 cd15363
leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of ...
 447-719 2.42e-96

leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor LGR6, together with its family members LGR4 and LGR5, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR6 serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages, whereas LGR5 is a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320485  Cd Length: 274  Bit Score: 302.53  E-value: 2.42e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 447 WGIRLAVWAIVLLSVLCNGLVLLTVFAGgPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 526
Cdd:cd15363    1 WLIRIGVWTIAVLALVCNALVTATVFRS-PLYISSIKLLIGLIAIVNMLMGVSSAVLAGVDAFTFGSFAQHGAWWESGVG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 527 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYa 606
Cdd:cd15363   80 CQITGFLSIFASESSVFLLTLAALERGFSVKCSTKFETKSPFLSLKAIILLCFLLALTIAVIPLLGGSEYGASPLCLPL- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 607 pPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 686
Cdd:cd15363  159 -PFGEPSAMGYMVALVLLNSLCFLVMTIAYTKLYCSLEKGELENIWDCSMVKHIALLLFTNCILYCPVAFLSFSSLLNLT 237

                        250       260       270
                 ....*....|....*....|....*....|...
gi 767910076 687 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 719
Cdd:cd15363  238 FISPEVIKFILLVIVPLPACLNPLLYILFNPHF 270
7tmA_LGR4 cd15361
leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of ...
 447-719 1.92e-76

leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor Lgr4 (formerly known as Gpr48), together with its close family members LGR5 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320483  Cd Length: 274  Bit Score: 249.78  E-value: 1.92e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 447 WGIRLAVWAIVLLSVLCNGLVLLTVFAGGpVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 526
Cdd:cd15361    1 WMIRLTVWFIFLVALFFNLLVILTTFASC-TSLPSSKLFVGLIAVSNLFMGVYTGILTFLDTVSWGRFAEFGIWWETGSG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 527 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYa 606
Cdd:cd15361   80 CKVAGFLAVFSSESAIFLLMLAAVERSLSAKDIMKKGKSNRLRQFQIAALLAFLVATAAGCLPLFHGGEYSASPLCLPF- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 607 pPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 686
Cdd:cd15361  159 -PTGETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAI 237

                        250       260       270
                 ....*....|....*....|....*....|...
gi 767910076 687 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 719
Cdd:cd15361  238 SISPEIMKSVTLIFFPLPACLNPVLYVFFNPKF 270
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
 447-719 3.39e-39

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 147.00  E-value: 3.39e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 447 WGIRLAVWAIVLLSVLCNGLVLLTVF----AGGPVPlppvKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWE 522
Cdd:cd14980    1 ISLRIFIWIIGILALIGNILVIIWHIsskkKKKKVP----KLLIINLAIADFLMGIYLLIIAIADQYYRGRYAQYSEEWL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 523 TGLGCRATGFLAVLGSEASVLLLTLAAVQ----CSVSVSCVRAYGKSP--------SLGSVRAGVLGCLalaglaaalpl 590
Cdd:cd14980   77 RSPPCLLACFLVSLSSLMSVLMMLLITLDryicIVYPFSNKRLSYKSAkiililgwLFSIIFAAIPILY----------- 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 591 aSVGE------YGASPLCLPYAPpeGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAV-----WDCAMVRH 659
Cdd:cd14980  146 -SINQpgdnrlYGYSSICMPSNV--SNPYYRGWLIAYLLLTFIAWIIICILYILIFISVRKSRKSARrssskRDKRIAIR 222

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 660 VAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 719
Cdd:cd14980  223 LALILITDLICWLPYYIVIFSGLLTSTEIDIHVLQFIAILALPLNSAINPYLYTLTTPTF 282
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
 447-719 2.63e-36

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 138.50  E-value: 2.63e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 447 WGIRLAVWAIVLLSVLCNG---LVLLTVFAGGPVPlppvKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWET 523
Cdd:cd15136    1 WWLRIGVWFVFLLALVGNIivlLVLLTSRTKLTVP----RFLMCNLAFADFCMGIYLGLLAIVDAKTLGEYYNYAIDWQT 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 524 GLGCRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCL 603
Cdd:cd15136   77 GAGCKTAGFLAVFSSELSVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALIMALLPLVGVSSYSKTSICL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 604 PYAppEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVW-DCAMVRHVAWLIFADGLLYCPVAFLSFASM 682
Cdd:cd15136  157 PFE--TETPVSKAYVIFLLLFNGLAFLIICGCYIKIYLSVRGSGRAANSnDTRIAKRMALLVFTDFLCWAPIAFFGLTAA 234

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 767910076 683 LGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 719
Cdd:cd15136  235 FGLPLISVSNAKILLVFFYPLNSCANPFLYAIFTKQF 271
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
33-350 9.50e-35

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 137.76  E-value: 9.50e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076  33 NNLTELQPGLFHHLRFLEELRLSGNhlshipgQAFSGLYSLKILMLQNNQLGGIPAEaLWELPSLQSLHLHNNRIQHLGT 112
Cdd:COG4886   82 LSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPE 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 113 hSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEkafmgnpllqtihfydnpiqfvgrsafqylpkl 192
Cdd:COG4886  154 -PLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE--------------------------------- 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 193 htlslngamdiqefpDLKGTTSLEILTLTRAGIRLLPSGMcQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIW 272
Cdd:COG4886  200 ---------------PLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLT 263

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767910076 273 EIgaDTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSF 350
Cdd:COG4886  264 DL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
31-331 6.42e-31

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 126.20  E-value: 6.42e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076  31 SMNNLTELQ---PGLFHHLRFLEELRLSGNHLSHIPgQAFSGLYSLKILMLQNNQLGGIPaEALWELPSLQSLHLHNNRI 107
Cdd:COG4886   94 DLTNLTELDlsgNEELSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQL 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 108 QHLGThSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEkAFMGNPLLQTIHFYDNPIQFVgrSAFQ 187
Cdd:COG4886  172 TDLPE-ELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDL--PELG 247

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 188 YLPKLHTLSLNGaMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQ 267
Cdd:COG4886  248 NLTNLEELDLSN-NQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLL 326

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767910076 268 HNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLM 331
Cdd:COG4886  327 LLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLL 390
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
 449-719 3.38e-26

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 109.22  E-value: 3.38e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 449 IRLAVWAIVLLSVLCNGLVLLTVFAGGpVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCR 528
Cdd:cd15964    3 LRIVVWFVNLLAILGNVFVLLILLTSH-YKLTVPRFLMCNLAFADFCMGIYLLLIASVDLHTRSEYYNHAIDWQTGPGCN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 529 ATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPP 608
Cdd:cd15964   82 TAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHASAIMLGGWVFCFLLALLPLVGVSSYAKVSICLPMDTE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 609 egQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEA-VWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFP 687
Cdd:cd15964  162 --TPLAQAYIVFVLMLNIIAFVIICACYIKIYITVRNPQYKSgDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPL 239

                        250       260       270
                 ....*....|....*....|....*....|..
gi 767910076 688 VTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 719
Cdd:cd15964  240 ITVSNSKILLVLFYPLNSCANPFLYAIFTKAF 271
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
 449-719 3.50e-23

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 100.32  E-value: 3.50e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 449 IRLAVWAIVLLSVLCNgLVLLTVFAGGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCR 528
Cdd:cd15360    3 LRVLIWFINILAITGN-IVVLAILLTSQYKLTVPRFLMCNLAFADLCMGIYLLLIASVDIRTKSQYYNYAIDWQTGAGCA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 529 ATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPP 608
Cdd:cd15360   82 AAGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKVRLRHAAVIMVGGWIFAFTVALLPIFGISSYMKVSICLPMDIE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 609 egQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDF-EAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFP 687
Cdd:cd15360  162 --SPLSQAYIIFILVLNVLAFLIICACYIKIYLTVRNPNFvSSNSDTKIAKRMAVLIFTDFLCMAPISFFAISASLKVPL 239

                        250       260       270
                 ....*....|....*....|....*....|..
gi 767910076 688 VTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 719
Cdd:cd15360  240 ITVSKSKILLVLFYPINSCANPFLYAIFTKTF 271
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
 449-719 1.80e-21

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 95.32  E-value: 1.80e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 449 IRLAVWAIVLLSVLCNGLVLLtVFAGGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCR 528
Cdd:cd15359    3 LRVLIWFINILAIAGNLIVLF-VLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKSQYYNHAIDWQTGSGCS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 529 ATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPP 608
Cdd:cd15359   82 TAGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKLRLRHAILIMLGGWVFSLLIAVLPLVGVSNYMKVSICLPMDIE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 609 EGQPAAlgFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAV-WDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFP 687
Cdd:cd15359  162 TLLSQA--YILLILVLNVIAFLVICACYIKIYLAVQNPELVAKnKDTKIAKRMAILIFTDFTCMAPISFFAISAAFKVPL 239

                        250       260       270
                 ....*....|....*....|....*....|..
gi 767910076 688 VTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 719
Cdd:cd15359  240 ITVTNSKILLVLFYPINSCANPFLYAIFTKAF 271
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
 449-719 1.35e-19

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 89.95  E-value: 1.35e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 449 IRLAVWAIVLLSVLCNGLVL---LTVFAGGPVPLppvkFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGL 525
Cdd:cd15137    3 LRVFIWVVGIIALLGNLFVLiwrLKYKEENKVHS----FLIKNLAIADFLMGVYLLIIASVDLYYRGVYIKHDEEWRSSW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 526 GCRATGFLAVLGSEASVLLLTLAAVQ---CSVS-VSCVRAygKSPSLGSVRAGVLGCLALAGLAAALPLASVGE-YGASP 600
Cdd:cd15137   79 LCTFAGFLATLSSEVSVLILTLITLDrfiCIVFpFSGRRL--GLRRAIIVLACIWLIGLLLAVLPLLPWDYFGNfYGRSG 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 601 LCLPYAPPEGQPAALGFTVALVM-MNSFCFLVVAGAYIKLYCDLPR-----GDFEAVWDCAMVRHVAWLIFADGLLYCPV 674
Cdd:cd15137  157 VCLPLHITDERPAGWEYSVFVFLgLNFLAFVFILLSYIAMFISIRRtrkaaASRKSKRDMAVAKRFFLIVLTDFLCWIPI 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 767910076 675 AFLSFASMLGlFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 719
Cdd:cd15137  237 IVIGILALSG-VPIPGEVYAWVAVFVLPINSALNPILYTLSTPKF 280
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
94-358 5.60e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 90.38  E-value: 5.60e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076  94 LPSLQSLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIhf 173
Cdd:COG4886    2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSL-- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 174 YDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFpdlkgtTSLEILTLTRAGIRLLPSGMcQQLPRLRVLELSHNQIEELP 253
Cdd:COG4886   80 LLLSLLLLGLTDLGDLTNLTELDLSGNEELSNL------TNLESLDLSGNQLTDLPEEL-ANLTNLKELDLSNNQLTDLP 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 254 SlhrcqkleeiglqhnriweigadTFSQLSSLQALDLSWNAIRSIhPEAFSTLHSLVKLDLTDNQLTTLP--LAGLGGLM 331
Cdd:COG4886  153 E-----------------------PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPepLGNLTNLE 208

                        250       260
                 ....*....|....*....|....*....
gi 767910076 332 HLKLKGNL--ALSQAFSKdsFPKLRILEV 358
Cdd:COG4886  209 ELDLSGNQltDLPEPLAN--LTNLETLDL 235
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 29-326 1.53e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 91.06  E-value: 1.53e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076  29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLS-HIPGqAFSGLYSLKILMLQNNQL-GGIPAEalwelpslqsLHLHNN- 105
Cdd:PLN00113 290 DLSDNSLSGEIPELVIQLQNLEILHLFSNNFTgKIPV-ALTSLPRLQVLQLWSNKFsGEIPKN----------LGKHNNl 358

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 106 RIQHLGTHSF-----EGL---HNLETLDLNYNKLQ-EFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDN 176
Cdd:PLN00113 359 TVLDLSTNNLtgeipEGLcssGNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNN 438

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 177 PIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIR-LLPSGMcQQLPRLRVLELSHNQIE-ELPS 254
Cdd:PLN00113 439 NLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKL-GSLSELMQLKLSENKLSgEIPD 517

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767910076 255 -LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQL-TTLPLAG 326
Cdd:PLN00113 518 eLSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLhGSLPSTG 591
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 30-320 3.04e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 89.91  E-value: 3.04e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076  30 LSMNNLTELQPGLFHHLRFLEELRLSGNHLS-HIPgQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLHLHNNRI- 107
Cdd:PLN00113 267 LYQNKLSGPIPPSIFSLQKLISLDLSDNSLSgEIP-ELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFs 345

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 108 ----QHLGTHSfeglhNLETLDLNYNKLQ-EFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVG 182
Cdd:PLN00113 346 geipKNLGKHN-----NLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGEL 420

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 183 RSAFQYLPKLHTLSLNGAmdiqefpDLKGTTSleiltlTRAgirllpsgmcQQLPRLRVLELSHNQIE-ELPSLHRCQKL 261
Cdd:PLN00113 421 PSEFTKLPLVYFLDISNN-------NLQGRIN------SRK----------WDMPSLQMLSLARNKFFgGLPDSFGSKRL 477

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767910076 262 EEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLT 320
Cdd:PLN00113 478 ENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLS 536
LRR_8 pfam13855
Leucine rich repeat;
49-107 1.47e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 68.71  E-value: 1.47e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767910076   49 LEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLHLHNNRI 107
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 29-338 1.83e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 77.97  E-value: 1.83e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076  29 DLSMNNLTELQPGLFhhLRFLEELRLSGNHLS-------------------------HIPGqAFSGLYSLKILMLQNNQL 83
Cdd:PLN00113 124 NLSNNNFTGSIPRGS--IPNLETLDLSNNMLSgeipndigsfsslkvldlggnvlvgKIPN-SLTNLTSLEFLTLASNQL 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076  84 -GGIPAEaLWELPSLQSLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQ-EFPVAIRTLGRLQELGFHNNNIKA-IPEK 160
Cdd:PLN00113 201 vGQIPRE-LGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSGpIPPS 279

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 161 AFMGNPL-----------------------LQTIHFYDNpiQFVGR--SAFQYLPKLHTLSLNGAMDIQEFP-DLKGTTS 214
Cdd:PLN00113 280 IFSLQKLisldlsdnslsgeipelviqlqnLEILHLFSN--NFTGKipVALTSLPRLQVLQLWSNKFSGEIPkNLGKHNN 357

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 215 LEILTLTRAGIR-LLPSGMCQQlPRLRVLELSHNQIE-ELP-SLHRCQKLEEIGLQHNRI----------------WEIG 275
Cdd:PLN00113 358 LTVLDLSTNNLTgEIPEGLCSS-GNLFKLILFSNSLEgEIPkSLGACRSLRRVRLQDNSFsgelpseftklplvyfLDIS 436

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767910076 276 ADTFS--------QLSSLQALDLSWNAIRSIHPEAFSTlHSLVKLDLTDNQLT-TLP--LAGLGGLMHLKLKGN 338
Cdd:PLN00113 437 NNNLQgrinsrkwDMPSLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSgAVPrkLGSLSELMQLKLSEN 509
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 52-323 2.46e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 72.90  E-value: 2.46e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076  52 LRLSGNHLSHIPGqaFSGLYSLKILMLQNNQLGGIpaEALWELPSLQSLHLHNNRIQHLGthSFEGLHNLETLDLNYNKl 131
Cdd:cd21340    7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNR- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 132 qefpvaIRTLGRLQELgfhnnnikaipekafmgnPLLQTIHFyDNpiqfvgrsafQYLPKlhtlslngamdiqefpdlkg 211
Cdd:cd21340   80 ------ISVVEGLENL------------------TNLEELHI-EN----------QRLPP-------------------- 104

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 212 TTSLEILTLTRAGIRllpsgmcqqlPRLRVLELSHNQIEELPSLhrcqkleeiglqhnriweigadtfSQLSSLQALDLS 291
Cdd:cd21340  105 GEKLTFDPRSLAALS----------NSLRVLNISGNNIDSLEPL------------------------APLRNLEQLDAS 150

                        250       260       270
                 ....*....|....*....|....*....|....
gi 767910076 292 WNAIRSIHP--EAFSTLHSLVKLDLTDNQLTTLP 323
Cdd:cd21340  151 NNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
259-319 3.64e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 67.55  E-value: 3.64e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767910076  259 QKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQL 319
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 191-338 9.10e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 71.36  E-value: 9.10e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 191 KLHTLSLNGaMDIQEFPDLKGTTSLEILTLTRAGIRLLPSgmCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNR 270
Cdd:cd21340    3 RITHLYLND-KNITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 271 IWEI-GADTFSQLS---------------------------SLQALDLSWNAIRSIHPeaFSTLHSLVKLDLTDNQLT-- 320
Cdd:cd21340   80 ISVVeGLENLTNLEelhienqrlppgekltfdprslaalsnSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISdl 157

                        170       180
                 ....*....|....*....|.
gi 767910076 321 ---TLPLAGLGGLMHLKLKGN 338
Cdd:cd21340  158 eelLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
72-131 4.88e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.47  E-value: 4.88e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076   72 SLKILMLQNNQLGGIPAEALWELPSLQSLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKL 131
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
95-154 1.21e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 63.31  E-value: 1.21e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767910076   95 PSLQSLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNI 154
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 33-158 2.56e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.04  E-value: 2.56e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076  33 NNLTELQPglFHHLRFLEELRLSGNHLSHIPGqaFSGLYSLKILMLQNNQLGgiPAEAL--------WELPSLQSLHLHN 104
Cdd:cd21340   56 NQIEKIEN--LENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRLP--PGEKLtfdprslaALSNSLRVLNISG 129

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767910076 105 NRIQHLgtHSFEGLHNLETLDLNYNKLQEFP---VAIRTLGRLQELGFHNNNIKAIP 158
Cdd:cd21340  130 NNIDSL--EPLAPLRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGNPVCKKP 184
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 42-277 3.99e-11

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 65.07  E-value: 3.99e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076  42 LFHHLRFLEELRLSGNHLSHIPGQA-FSGL---YSLKILMLQNNQLGGIPA------EALWELPSLQSLHLHNNRIQHLG 111
Cdd:cd00116   18 LLPKLLCLQVLRLEGNTLGEEAAKAlASALrpqPSLKELCLSLNETGRIPRglqsllQGLTKGCGLQELDLSDNALGPDG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 112 THSFEGLH---NLETLDLNYNKLQEFPVAI--RTLG----RLQELGFHNNNIKAIP----EKAFMGNPLLQTIHFYDNPI 178
Cdd:cd00116   98 CGVLESLLrssSLQELKLNNNGLGDRGLRLlaKGLKdlppALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGI 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 179 QFVG-RSAFQYLP---KLHTLSLN-------GAMDIQE-FPDLKgttSLEILTL-----TRAGIRLLPSGMCQQLPRLRV 241
Cdd:cd00116  178 GDAGiRALAEGLKancNLEVLDLNnngltdeGASALAEtLASLK---SLEVLNLgdnnlTDAGAAALASALLSPNISLLT 254

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 767910076 242 LELSHNQIEELPSLHRCQ------KLEEIGLQHNRIWEIGAD 277
Cdd:cd00116  255 LSLSCNDITDDGAKDLAEvlaekeSLLELDLRGNKFGEEGAQ 296
7tmA_RXFP2_LGR8 cd15966
relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G ...
 492-719 1.00e-10

relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural similarity, but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. INSL3 is the endogenous ligand for RXFP2, which couples to the G(s) protein to increase intracellular cAMP levels, but also to the GoB protein to decrease cAMP formation. RXFP2 (or LGR8) is expressed in various tissues including the brain, kidney, muscle, testis, thyroid, uterus, and peripheral blood cells, among others.


Pssm-ID: 320632  Cd Length: 287  Bit Score: 63.65  E-value: 1.00e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 492 ANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSV----SCVRAyGKSPS 567
Cdd:cd15966   45 ADCLMGVYLFFVGIFDVKYRGEYNKYALLWMESLQCRIIGFLAMLSTEVSVLLLTYLTLEKYLVIvfpfSNIRP-GKCQT 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 568 LgSVRAGVLGCLALAGLAAALPLASVGE-YGASPLCLP-YAPPEGQPAALGFTVALVM-MNSFCFLVVAGAYIKLYCDLP 644
Cdd:cd15966  124 L-IILISIWLVGFIIAVIPFWNEDFFGNyYGKNGVCFPlHSDQTEKIGAKGYSTGIFLgLNLLAFIIIVFSYSSMFCSIQ 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 645 RGDFEAV-------WDCAMVRHVAWLIFADGLLYCPVAFLsfaSMLGLFPV-TPEAVKS-VLLVVLPLPACLNPLLYLLF 715
Cdd:cd15966  203 KTGLQTTevrshihRDVAVANRFFFIVFSDAICWIPIFLL---KILSLFQVeIPGTITSwIVIFILPINSALNPILYTLT 279


                 ....
gi 767910076 716 NPHF 719
Cdd:cd15966  280 TSFF 283
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 29-296 9.18e-10

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 61.73  E-value: 9.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076  29 DLSMNNLTELQPGLFHHLRFLEEL-------------RLSGNHLSHIPGQAFSGLY-----SLKILMLQNNQLGGIPAEA 90
Cdd:COG5238  120 RRIMAKTLEDSLILYLALPRRINLiqvlkdplggnavHLLGLAARLGLLAAISMAKalqnnSVETVYLGCNQIGDEGIEE 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076  91 LWEL----PSLQSLHLHNNRIQHLGTHSF----EGLHNLETLDLNYNK-----LQEFPVAIRTLGRLQELGFHNNNI--- 154
Cdd:COG5238  200 LAEAltqnTTVTTLWLKRNPIGDEGAEILaealKGNKSLTTLDLSNNQigdegVIALAEALKNNTTVETLYLSGNQIgae 279

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 155 --KAIpEKAFMGNPLLQTIHFYDNPIQFVGRSAFQylpklhtlslngamdiqefPDLKGTTSLEILTLTRAGIRllPSGM 232
Cdd:COG5238  280 gaIAL-AKALQGNTTLTSLDLSVNRIGDEGAIALA-------------------EGLQGNKTLHTLNLAYNGIG--AQGA 337

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767910076 233 ------CQQLPRLRVLELSHNQI-----EEL-PSLHRCQKLEEIGLQHNRIWEIGADTF---SQLSSLQALDLSWNAIR 296
Cdd:COG5238  338 ialakaLQENTTLHSLDLSDNQIgdegaIALaKYLEGNTTLRELNLGKNNIGKQGAEALidaLQTNRLHTLILDGNLIG 416
LRR_8 pfam13855
Leucine rich repeat;
29-83 1.07e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.84  E-value: 1.07e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767910076   29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQL 83
Cdd:pfam13855   7 DLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
8-323 1.64e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.17  E-value: 1.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076   8 RSARAGQNLSRAGSARRgaPRDLSMNNLTEL---QPGLFHHLRFLEE----LRLSGNHLSHIPgQAFSGlySLKILMLQN 80
Cdd:PRK15370 155 KEAPAKEAANREEAVQR--MRDCLKNNKTELrlkILGLTTIPACIPEqittLILDNNELKSLP-ENLQG--NIKTLYANS 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076  81 NQLGGIPAEalweLP-SLQSLHLHNNRIQHLGTHSFEGLhnlETLDLNYNKLQEFPVAIRTlgRLQELGFHNNNIKAIPE 159
Cdd:PRK15370 230 NQLTSIPAT----LPdTIQEMELSINRITELPERLPSAL---QSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPA 300

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 160 KAFMGnpllqTIHFydnpiqFVGRSAFQYLPKlhTLSLNgamdiqefpdlkgttsLEILTLTRAGIRLLPSGMCqqlPRL 239
Cdd:PRK15370 301 HLPSG-----ITHL------NVQSNSLTALPE--TLPPG----------------LKTLEAGENALTSLPASLP---PEL 348

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 240 RVLELSHNQIEELPslhrcqkleeiglqhnriweigaDTFSqlSSLQALDLSWNAIRSIhPEAFSTlhSLVKLDLTDNQL 319
Cdd:PRK15370 349 QVLDVSKNQITVLP-----------------------ETLP--PTITTLDVSRNALTNL-PENLPA--ALQIMQASRNNL 400


                 ....
gi 767910076 320 TTLP 323
Cdd:PRK15370 401 VRLP 404
LRR_8 pfam13855
Leucine rich repeat;
283-339 2.02e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.37  E-value: 2.02e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076  283 SSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP---LAGLGGLMHLKLKGNL 339
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgaFSGLPSLRYLDLSGNR 60
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 115-320 2.08e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 56.98  E-value: 2.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 115 FEGLHNLETLDLNYNKLQE------------FPVAIRTLGRLQELGFHNNNIKAIPEkAFMGNPLLQTIHFYDNPIQFVG 182
Cdd:cd00116   19 LPKLLCLQVLRLEGNTLGEeaakalasalrpQPSLKELCLSLNETGRIPRGLQSLLQ-GLTKGCGLQELDLSDNALGPDG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 183 RSAFQYL---PKLHTLSLN--------GAMDIQEFPDLKgtTSLEILTLTRagiRLLPSGMCQQL-------PRLRVLEL 244
Cdd:cd00116   98 CGVLESLlrsSSLQELKLNnnglgdrgLRLLAKGLKDLP--PALEKLVLGR---NRLEGASCEALakalranRDLKELNL 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 245 SHNQIEE------LPSLHRCQKLEEIGLQHNRIWEIG----ADTFSQLSSLQALDLSWNAIRS-----IHPEAFSTLHSL 309
Cdd:cd00116  173 ANNGIGDagiralAEGLKANCNLEVLDLNNNGLTDEGasalAETLASLKSLEVLNLGDNNLTDagaaaLASALLSPNISL 252

                        250
                 ....*....|.
gi 767910076 310 VKLDLTDNQLT 320
Cdd:cd00116  253 LTLSLSCNDIT 263
LRR_8 pfam13855
Leucine rich repeat;
237-295 2.27e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.37  E-value: 2.27e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767910076  237 PRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAI 295
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDdgAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 138-327 4.03e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 55.82  E-value: 4.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 138 IRTLGRLQELGFHNNNI-----KAIPEKAfMGNPLLQTIHFYDNPIQFVGR------SAFQYLPKLHTLSLN----GAMD 202
Cdd:cd00116   19 LPKLLCLQVLRLEGNTLgeeaaKALASAL-RPQPSLKELCLSLNETGRIPRglqsllQGLTKGCGLQELDLSdnalGPDG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 203 IQEFPDLKGTTSLEILTLTRAGI-----RLLPSGMCQQLPRLRVLELSHNQIE---------ELPSLhrcQKLEEIGLQH 268
Cdd:cd00116   98 CGVLESLLRSSSLQELKLNNNGLgdrglRLLAKGLKDLPPALEKLVLGRNRLEgascealakALRAN---RDLKELNLAN 174

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767910076 269 NRIWEIGADT----FSQLSSLQALDLSWNAIR----SIHPEAFSTLHSLVKLDLTDNQLTTLPLAGL 327
Cdd:cd00116  175 NGIGDAGIRAlaegLKANCNLEVLDLNNNGLTdegaSALAETLASLKSLEVLNLGDNNLTDAGAAAL 241
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 48-338 1.78e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 54.41  E-value: 1.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076  48 FLEELRLSGNHLSHIPGQAFSGLySLKILMLQNNQLGGIPAEALWELPSL---QSLHLHNNRIQHLGTHS---FEGLHNL 121
Cdd:COG5238  104 ALAETATAVATPPPDLRRIMAKT-LEDSLILYLALPRRINLIQVLKDPLGgnaVHLLGLAARLGLLAAISmakALQNNSV 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 122 ETLDLNYNKLQEfpVAIRTLGrlqelgfhnnnikaipeKAFMGNPLLQTIHFYDNPIQFVGRSAF----QYLPKLHTLSL 197
Cdd:COG5238  183 ETVYLGCNQIGD--EGIEELA-----------------EALTQNTTVTTLWLKRNPIGDEGAEILaealKGNKSLTTLDL 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 198 N-------GAMDIQEFpdLKGTTSLEILTL-----TRAGIRLLPSGMcQQLPRLRVLELSHNQIEE------LPSLHRCQ 259
Cdd:COG5238  244 SnnqigdeGVIALAEA--LKNNTTVETLYLsgnqiGAEGAIALAKAL-QGNTTLTSLDLSVNRIGDegaialAEGLQGNK 320

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767910076 260 KLEEIGLQHNRIWEIGADTFSQlsSLQALdlswnairsihpeafSTLHSLvklDLTDNQLTTlplAGLGGLMHLkLKGN 338
Cdd:COG5238  321 TLHTLNLAYNGIGAQGAIALAK--ALQEN---------------TTLHSL---DLSDNQIGD---EGAIALAKY-LEGN 375
7tmA_RXFP1_LGR7 cd15965
relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G ...
 492-714 6.51e-07

relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. Relaxin is the endogenous ligand for RXFP1, which has a large extracellular N-terminal domain containing 10 leucine-rich repeats and a unique low-density lipoprotein type A (LDLa) module which is necessary for receptor activation. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP and nitric oxide. RXFP1 is expressed in various tissues including uterus, ovary, placenta, cerebral cortex, heart, lung and kidney, among others.


Pssm-ID: 320631 [Multi-domain]  Cd Length: 287  Bit Score: 51.79  E-value: 6.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 492 ANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQ---CSV-SVSCVRAyGKSPS 567
Cdd:cd15965   45 ADCLMGIYLFVIGAFDLKYRGEYNKHAQLWMDSTQCQLVGSLAILSTEVSVLLLTYLTLEkyiCIVyPFRCLTP-GKCRT 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 568 LGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPY--APPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPR 645
Cdd:cd15965  124 ITILILIWIIGFIIAFIPLSNKEFFRNYYGTNGVCFPLhsEQPESTGAQIYSVVIFLGLNLAAFIIIVFSYGSMFYSIHQ 203

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767910076 646 GDFEAVW-------DCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLfpVTPEAVKS-VLLVVLPLPACLNPLLYLL 714
Cdd:cd15965  204 TAIMATEisnhikkEMTLAKRFFFIVFTDALCWIPIFILKLLSLLQV--EIPGTISSwVVIFILPINSALNPILYTL 278
LRR_8 pfam13855
Leucine rich repeat;
143-199 1.04e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 1.04e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767910076  143 RLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNG 199
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSG 58
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 52-358 2.45e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.39  E-value: 2.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076  52 LRLSGNHLSHIPGQAFSGLYSLKILMLQNNQL-GGIPAEALWELPSLQSLHLHNNRIQhlGTHSFEGLHNLETLDLNYNK 130
Cdd:PLN00113  74 IDLSGKNISGKISSAIFRLPYIQTINLSNNQLsGPIPDDIFTTSSSLRYLNLSNNNFT--GSIPRGSIPNLETLDLSNNM 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 131 LQ-EFPvairtlgrlQELGFHNNnikaipekafmgnpllqtihfydnpiqfvgrsafqylpkLHTLSLNGAMDIQEFP-D 208
Cdd:PLN00113 152 LSgEIP---------NDIGSFSS---------------------------------------LKVLDLGGNVLVGKIPnS 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 209 LKGTTSLEILTLTRagiRLLPSGMCQQLPRLRVLE---LSHNQIE-ELP-SLHRCQKLEEIGLQHNRIWEIGADTFSQLS 283
Cdd:PLN00113 184 LTNLTSLEFLTLAS---NQLVGQIPRELGQMKSLKwiyLGYNNLSgEIPyEIGGLTSLNHLDLVYNNLTGPIPSSLGNLK 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 284 SLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTtlplaglGGLMHLKLK-GNLALSQAFSKD----------SFPK 352
Cdd:PLN00113 261 NLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLS-------GEIPELVIQlQNLEILHLFSNNftgkipvaltSLPR 333


                 ....*.
gi 767910076 353 LRILEV 358
Cdd:PLN00113 334 LQVLQL 339
PLN03150 PLN03150
hypothetical protein; Provisional
 257-330 2.18e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 48.27  E-value: 2.18e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767910076 257 RCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGL 330
Cdd:PLN03150 440 KLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAALGGR 513
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 237-269 3.60e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 41.46  E-value: 3.60e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 767910076  237 PRLRVLELSHNQIEELPSLHRCQKLEEIGLQHN 269
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGN 33
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 96-188 4.83e-05

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 43.69  E-value: 4.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076   96 SLQSLHLHNNrIQHLGTHSFEGLHNLETLDLNYNklqefpvaIRTLGR-------LQELGFhNNNIKAIPEKAFMGNPLL 168
Cdd:pfam13306  12 SLTSITIPSS-LTSIGEYAFSNCTSLKSITLPSS--------LTSIGSyafyncsLTSITI-PSSLTSIGEYAFSNCSNL 81

                          90       100
                  ....*....|....*....|
gi 767910076  169 QTIHFYDNpIQFVGRSAFQY 188
Cdd:pfam13306  82 KSITLPSN-LTSIGSYAFSN 100
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 95-131 8.89e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 40.69  E-value: 8.89e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 767910076   95 PSLQSLHLHNNRIQHLGthSFEGLHNLETLDLNYNKL 131
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNK 35
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
218-366 1.03e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.84  E-value: 1.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 218 LTLTRAGIRLLPSGMCQQLPRLRVLElshNQIEELPSLHRcQKLEEIGLQHNRIWEIGadtfSQL-SSLQALDLSWNAIR 296
Cdd:PRK15370 204 LILDNNELKSLPENLQGNIKTLYANS---NQLTSIPATLP-DTIQEMELSINRITELP----ERLpSALQSLDLFHNKIS 275

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767910076 297 SIhPEAFStlHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNlalSQAFSKDSFP-KLRILEV-PYAYQCCP 366
Cdd:PRK15370 276 CL-PENLP--EELRYLSVYDNSIRTLPAHLPSGITHLNVQSN---SLTALPETLPpGLKTLEAgENALTSLP 341
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 49-192 1.53e-04

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 42.15  E-value: 1.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076   49 LEELRLSgNHLSHIPGQAFSGLYSLKILMLQNNqLGGIPAEALWELpSLQSLHLHNNrIQHLGTHSFEGLHNLETLDLny 128
Cdd:pfam13306  13 LTSITIP-SSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNC-SLTSITIPSS-LTSIGEYAFSNCSNLKSITL-- 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767910076  129 nklqefpvairtlgrlqelgfhNNNIKAIPEKAFMGNPlLQTIHFYDNpIQFVGRSAFQYLPKL 192
Cdd:pfam13306  87 ----------------------PSNLTSIGSYAFSNCS-LKSITIPSS-VTTIGSYAFSNCSNL 126
PLN03150 PLN03150
hypothetical protein; Provisional
 277-338 1.73e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 45.19  E-value: 1.73e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767910076 277 DTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLK---LKGN 338
Cdd:PLN03150 436 NDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRilnLNGN 500
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
 455-716 4.05e-04

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 43.05  E-value: 4.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 455 AIVLLSVLCNGLVLLTVFAGgPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQfseygarWETGLGCRATGFLA 534
Cdd:cd00637    7 LIFVVGLVGNLLVILVILRN-RRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRW-------WFGDALCKLLGFLQ 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 535 VLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAA 614
Cdd:cd00637   79 SVSLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLS 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076 615 LGFTVALVMMNSF-CFLVVAGAYIKLYCDL-------------PRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFA 680
Cdd:cd00637  159 KAYTIFLFVLLFLlPLLVIIVCYVRIFRKLrrhrrrirssssnSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLLL 238

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 767910076 681 SMLGLFPV-TPEAVKSVLLVVLPLPACLNPLLYLLFN 716
Cdd:cd00637  239 DVFGPDPSpLPRILYFLALLLAYLNSAINPIIYAFFN 275
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 61-351 5.23e-04

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 43.71  E-value: 5.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076   61 HIPGQAFSGLYSLKILMLQNNQLGGiPAEALWELPS--------LQSLHLHNNRIQHLGThSFEGlHNLETLDLNYNKLQ 132
Cdd:PLN03210  548 HIHENAFKGMRNLLFLKFYTKKWDQ-KKEVRWHLPEgfdylppkLRLLRWDKYPLRCMPS-NFRP-ENLVKLQMQGSKLE 624

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076  133 EFPVAIRTLGRLQELGFH-NNNIKAIPEKAFMGNplLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKG 211
Cdd:PLN03210  625 KLWDGVHSLTGLRNIDLRgSKNLKEIPDLSMATN--LETLKLSDCSSLVELPSSIQYLNKLEDLDMSRCENLEILPTGIN 702

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076  212 TTSLEILTLTR-AGIRLLPSGMCQqlprLRVLELSHNQIEELPSLHRCQKLEEIGL---QHNRIWE---IGADTFSQLS- 283
Cdd:PLN03210  703 LKSLYRLNLSGcSRLKSFPDISTN----ISWLDLDETAIEEFPSNLRLENLDELILcemKSEKLWErvqPLTPLMTMLSp 778

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767910076  284 SLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTD-NQLTTLPLAglgglMHLKLKGNLALSQAFSKDSFP 351
Cdd:PLN03210  779 SLTRLFLSDIPSLVELPSSIQNLHKLEHLEIENcINLETLPTG-----INLESLESLDLSGCSRLRTFP 842
PLN03150 PLN03150
hypothetical protein; Provisional
 76-177 5.50e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.65  E-value: 5.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076  76 LMLQNNQLGGIPAEALWELPSLQSLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQ-EFPVAIRTLGRLQELGFHNNNI 154
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502

                         90       100
                 ....*....|....*....|....
gi 767910076 155 KAIPEKAFMGNPLLQTI-HFYDNP 177
Cdd:PLN03150 503 SGRVPAALGGRLLHRASfNFTDNA 526
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 72-110 6.36e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.00  E-value: 6.36e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 767910076   72 SLKILMLQNNQLGGIPAeaLWELPSLQSLHL-HNNRIQHL 110
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP--LAKLPNLETLDLsGNNKITDL 39
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 29-161 6.80e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.85  E-value: 6.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910076  29 DLSMNNLTElqPG---LFHHLRF---LEELRLSGNHLSHiPG-----QAFSGLYSLKILMLQNNQL---GGIP-AEALWE 93
Cdd:COG5238  270 YLSGNQIGA--EGaiaLAKALQGnttLTSLDLSVNRIGD-EGaialaEGLQGNKTLHTLNLAYNGIgaqGAIAlAKALQE 346

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767910076  94 LPSLQSLHLHNNRIQHLGT----HSFEGLHNLETLDLNYNKL--QEFPVAIRTL--GRLQELGFHNNNIKAIPEKA 161
Cdd:COG5238  347 NTTLHSLDLSDNQIGDEGAialaKYLEGNTTLRELNLGKNNIgkQGAEALIDALqtNRLHTLILDGNLIGAEAQQR 422
LRR smart00370
Leucine-rich repeats, outliers;
282-304 4.86e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 4.86e-03
                           10        20
                   ....*....|....*....|...
gi 767910076   282 LSSLQALDLSWNAIRSIHPEAFS 304
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQ 23
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
282-304 4.86e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 4.86e-03
                           10        20
                   ....*....|....*....|...
gi 767910076   282 LSSLQALDLSWNAIRSIHPEAFS 304
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQ 23
LRR smart00370
Leucine-rich repeats, outliers;
46-69 8.85e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 8.85e-03
                           10        20
                   ....*....|....*....|....
gi 767910076    46 LRFLEELRLSGNHLSHIPGQAFSG 69
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
46-69 8.85e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 8.85e-03
                           10        20
                   ....*....|....*....|....
gi 767910076    46 LRFLEELRLSGNHLSHIPGQAFSG 69
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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