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Conserved domains on  [gi|767916877|ref|XP_011508987|]
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ankyrin and armadillo repeat-containing protein isoform X7 [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
374-544 4.60e-18

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 86.16  E-value: 4.60e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916877  374 INVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRrfvtFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWM 453
Cdd:COG0666    80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNAR----DKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNT 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916877  454 PIHFAAFYDNVCIIIALCRKDPSLleaEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHT 533
Cdd:COG0666   156 PLHLAAANGNLEIVKLLLEAGADV---NARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNL 232

                         170
                  ....*....|.
gi 767916877  534 EVLKYIIKLNI 544
Cdd:COG0666   233 EIVKLLLEAGA 243
PLN03200 super family cl33659
cellulose synthase-interactive protein; Provisional
 592-797 2.69e-06

cellulose synthase-interactive protein; Provisional


The actual alignment was detected with superfamily member PLN03200:

Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 52.03  E-value: 2.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916877  592 IPALINLLKSSKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVHSRCAVILYDIAQCENKD-----V 666
Cdd:PLN03200   60 MPLLVSLLRSGTLGAKVNAAAVLGVLCKEEDLRVKVLLGGCIPPLLSLLKSGSAEAQKAAAEAIYAVSSGGLSDhvgskI 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916877  667 IAKYNGIPSLINLLN--LNIENVLVN-VMNCIRVLCIGNENNQRAVREHKGLPYLIRFLSSD--------SGLFNLFLNS 735
Cdd:PLN03200  140 FSTEGVVPSLWDQLQpgNKQDKVVEGlLTGALRNLCGSTDGFWSATLEAGGVDILVKLLSSGnsdaqanaASLLARLMMA 219

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767916877  736 FEDVLKAVSSAaiaevgrdnkeiqdaiameGAIPPLVALF-KGKQISVQMKGAMAVESLASHN 797
Cdd:PLN03200  220 FESSISKVLDA-------------------GAVKQLLKLLgQGNEVSVRAEAAGALEALSSQS 263
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
374-544 4.60e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 86.16  E-value: 4.60e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916877  374 INVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRrfvtFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWM 453
Cdd:COG0666    80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNAR----DKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNT 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916877  454 PIHFAAFYDNVCIIIALCRKDPSLleaEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHT 533
Cdd:COG0666   156 PLHLAAANGNLEIVKLLLEAGADV---NARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNL 232

                         170
                  ....*....|.
gi 767916877  534 EVLKYIIKLNI 544
Cdd:COG0666   233 EIVKLLLEAGA 243
Ank_2 pfam12796
Ankyrin repeats (3 copies);
422-517 2.50e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.51  E-value: 2.50e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916877   422 LHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEaeataENQCTPLLLAATSGALD 501
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK-----DNGRTALHYAARSGHLE 75

                           90
                   ....*....|....*.
gi 767916877   502 TIQYLFSIGANWRKTD 517
Cdd:pfam12796   76 IVKLLLEKGADINVKD 91
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 592-797 2.69e-06

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 52.03  E-value: 2.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916877  592 IPALINLLKSSKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVHSRCAVILYDIAQCENKD-----V 666
Cdd:PLN03200   60 MPLLVSLLRSGTLGAKVNAAAVLGVLCKEEDLRVKVLLGGCIPPLLSLLKSGSAEAQKAAAEAIYAVSSGGLSDhvgskI 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916877  667 IAKYNGIPSLINLLN--LNIENVLVN-VMNCIRVLCIGNENNQRAVREHKGLPYLIRFLSSD--------SGLFNLFLNS 735
Cdd:PLN03200  140 FSTEGVVPSLWDQLQpgNKQDKVVEGlLTGALRNLCGSTDGFWSATLEAGGVDILVKLLSSGnsdaqanaASLLARLMMA 219

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767916877  736 FEDVLKAVSSAaiaevgrdnkeiqdaiameGAIPPLVALF-KGKQISVQMKGAMAVESLASHN 797
Cdd:PLN03200  220 FESSISKVLDA-------------------GAVKQLLKLLgQGNEVSVRAEAAGALEALSSQS 263
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
534-696 1.99e-05

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 48.73  E-value: 1.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916877  534 EVLKYIIKLNIPelpvwKTLVEMLQCESYKRRMMAVMSLEVICLANDQYWRCILDAGTIPALINLLKSSKIKLQCKTVGL 613
Cdd:COG5064   276 EKIQAVLDVGIP-----GRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKENIRKEACWT 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916877  614 LSNIST-HKSAVHALVEAGGIPSLINLLVCDEPEVHSR-CAVILYDIAQCENKDVIAKY---NG-IPSLINLLNLNIENV 687
Cdd:COG5064   351 ISNITAgNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEaCWAISNATSGGLNRPDIIRYlvsQGfIKPLCDLLDVVDNKI 430


                  ....*....
gi 767916877  688 LVNVMNCIR 696
Cdd:COG5064   431 IEVALDAIE 439
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 579-619 2.05e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 42.83  E-value: 2.05e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767916877   579 NDQYWRCILDAGTIPALINLLKSSKIKLQCKTVGLLSNIST 619
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 586-618 1.24e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 40.49  E-value: 1.24e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 767916877    586 ILDAGTIPALINLLKSSKIKLQCKTVGLLSNIS 618
Cdd:smart00185    8 VVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 385-512 2.72e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 44.98  E-value: 2.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916877  385 FHHAALHNRVSIICQLCNANFKVNQrrfVTFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNV 464
Cdd:PHA02875   72 LHDAVEEGDVKAVEELLDLGKFADD---VFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDI 148

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767916877  465 CIIialcrkdPSLLEAEATAENQ----CTPLLLAATSGALDTIQYLFSIGAN 512
Cdd:PHA02875  149 KGI-------ELLIDHKACLDIEdccgCTPLIIAMAKGDIAICKMLLDSGAN 193
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
374-544 4.60e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 86.16  E-value: 4.60e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916877  374 INVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRrfvtFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWM 453
Cdd:COG0666    80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNAR----DKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNT 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916877  454 PIHFAAFYDNVCIIIALCRKDPSLleaEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHT 533
Cdd:COG0666   156 PLHLAAANGNLEIVKLLLEAGADV---NARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNL 232

                         170
                  ....*....|.
gi 767916877  534 EVLKYIIKLNI 544
Cdd:COG0666   233 EIVKLLLEAGA 243
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
374-544 2.74e-15

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 78.07  E-value: 2.74e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916877  374 INVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRfvtfSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWM 453
Cdd:COG0666   113 VNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQD----NDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGET 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916877  454 PIHFAAFYDNVCIIIALCRKDPSLleaEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHT 533
Cdd:COG0666   189 PLHLAAENGHLEIVKLLLEAGADV---NAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAA 265

                         170
                  ....*....|.
gi 767916877  534 EVLKYIIKLNI 544
Cdd:COG0666   266 LIVKLLLLALL 276
Ank_2 pfam12796
Ankyrin repeats (3 copies);
422-517 2.50e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.51  E-value: 2.50e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916877   422 LHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEaeataENQCTPLLLAATSGALD 501
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK-----DNGRTALHYAARSGHLE 75

                           90
                   ....*....|....*.
gi 767916877   502 TIQYLFSIGANWRKTD 517
Cdd:pfam12796   76 IVKLLLEKGADINVKD 91
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 592-797 2.69e-06

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 52.03  E-value: 2.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916877  592 IPALINLLKSSKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVHSRCAVILYDIAQCENKD-----V 666
Cdd:PLN03200   60 MPLLVSLLRSGTLGAKVNAAAVLGVLCKEEDLRVKVLLGGCIPPLLSLLKSGSAEAQKAAAEAIYAVSSGGLSDhvgskI 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916877  667 IAKYNGIPSLINLLN--LNIENVLVN-VMNCIRVLCIGNENNQRAVREHKGLPYLIRFLSSD--------SGLFNLFLNS 735
Cdd:PLN03200  140 FSTEGVVPSLWDQLQpgNKQDKVVEGlLTGALRNLCGSTDGFWSATLEAGGVDILVKLLSSGnsdaqanaASLLARLMMA 219

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767916877  736 FEDVLKAVSSAaiaevgrdnkeiqdaiameGAIPPLVALF-KGKQISVQMKGAMAVESLASHN 797
Cdd:PLN03200  220 FESSISKVLDA-------------------GAVKQLLKLLgQGNEVSVRAEAAGALEALSSQS 263
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 553-806 4.27e-06

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 51.64  E-value: 4.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916877  553 LVEMLQCESYKRRMMAVMSLEVICLANDQYWRCILDAGTIPALINLLKSSKIKLQ---CKTVGLLsnISTHKSAVhalve 629
Cdd:PLN03200  493 LVQLLETGSQKAKEDSATVLWNLCCHSEDIRACVESAGAVPALLWLLKNGGPKGQeiaAKTLTKL--VRTADAAT----- 565

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916877  630 aggIPSLINLLVCDEPEvhSRCAVIlyDIAQC-----ENKDVI----AKYNGIPSLINLLNLNIE-------NVLVNVMN 693
Cdd:PLN03200  566 ---ISQLTALLLGDLPE--SKVHVL--DVLGHvlsvaSLEDLVregsAANDALRTLIQLLSSSKEetqekaaSVLADIFS 638

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916877  694 CIRVLCigneNNQRAVrehKGLPYLIRFLSSDSglfnlflnsfeDVLKAVSSAAIAEVGRDNKEIQD-AIAMEGAIPPLV 772
Cdd:PLN03200  639 SRQDLC----ESLATD---EIINPCIKLLTNNT-----------EAVATQSARALAALSRSIKENRKvSYAAEDAIKPLI 700

                         250       260       270
                  ....*....|....*....|....*....|....
gi 767916877  773 ALFKGKQISVQMKGAMAVESLASHNALIQKAFLE 806
Cdd:PLN03200  701 KLAKSSSIEVAEQAVCALANLLSDPEVAAEALAE 734
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 558-793 6.51e-06

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 50.87  E-value: 6.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916877  558 QCESYKRRMMAVMSLEViclaNDQYWrCILDAGTIPALINLLKSSKIKLQCKTVGLLSNISTHKSAVHALVE-AGGIPSL 636
Cdd:PLN03200  461 QQQEYAVALLAILTDEV----DESKW-AITAAGGIPPLVQLLETGSQKAKEDSATVLWNLCCHSEDIRACVEsAGAVPAL 535

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916877  637 INLLVCDEPEVHSRCAVILYDIAQCENKDVIAKyngipsLINLLNLNIENVLVNVMNCIR-VLCIGNENN--QRAVREHK 713
Cdd:PLN03200  536 LWLLKNGGPKGQEIAAKTLTKLVRTADAATISQ------LTALLLGDLPESKVHVLDVLGhVLSVASLEDlvREGSAAND 609

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916877  714 GLPYLIRFLSSdsglfnlflnSFEDVlKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQISVQMKGAMAVESL 793
Cdd:PLN03200  610 ALRTLIQLLSS----------SKEET-QEKAASVLADIFSSRQDLCESLATDEIINPCIKLLTNNTEAVATQSARALAAL 678
Ank_4 pfam13637
Ankyrin repeats (many copies);
489-540 1.93e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.03  E-value: 1.93e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 767916877   489 TPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYII 540
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
534-696 1.99e-05

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 48.73  E-value: 1.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916877  534 EVLKYIIKLNIPelpvwKTLVEMLQCESYKRRMMAVMSLEVICLANDQYWRCILDAGTIPALINLLKSSKIKLQCKTVGL 613
Cdd:COG5064   276 EKIQAVLDVGIP-----GRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKENIRKEACWT 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916877  614 LSNIST-HKSAVHALVEAGGIPSLINLLVCDEPEVHSR-CAVILYDIAQCENKDVIAKY---NG-IPSLINLLNLNIENV 687
Cdd:COG5064   351 ISNITAgNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEaCWAISNATSGGLNRPDIIRYlvsQGfIKPLCDLLDVVDNKI 430


                  ....*....
gi 767916877  688 LVNVMNCIR 696
Cdd:COG5064   431 IEVALDAIE 439
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 579-619 2.05e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 42.83  E-value: 2.05e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767916877   579 NDQYWRCILDAGTIPALINLLKSSKIKLQCKTVGLLSNIST 619
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 586-618 1.24e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 40.49  E-value: 1.24e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 767916877    586 ILDAGTIPALINLLKSSKIKLQCKTVGLLSNIS 618
Cdd:smart00185    8 VVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 571-678 1.32e-04

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 46.63  E-value: 1.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916877  571 SLEVICLANDQYWRCILDAGTIPALINLLKSSKIKLQCKTVGLLSN-ISTHKSAVHALVEAGGIPSLINLLVC-DEPEVH 648
Cdd:PLN03200  170 ALRNLCGSTDGFWSATLEAGGVDILVKLLSSGNSDAQANAASLLARlMMAFESSISKVLDAGAVKQLLKLLGQgNEVSVR 249

                          90       100       110
                  ....*....|....*....|....*....|..
gi 767916877  649 SRCAVILYDI-AQC-ENKDVIAKYNGIPSLIN 678
Cdd:PLN03200  250 AEAAGALEALsSQSkEAKQAIADAGGIPALIN 281
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
419-541 1.71e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 44.94  E-value: 1.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916877  419 PTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDpslLEAEATAENQCTPLLLAATSG 498
Cdd:COG0666    22 ALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAG---ADINAKDDGGNTLLHAAARNG 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 767916877  499 ALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 541
Cdd:COG0666    99 DLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLE 141
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 385-512 2.72e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 44.98  E-value: 2.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916877  385 FHHAALHNRVSIICQLCNANFKVNQrrfVTFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNV 464
Cdd:PHA02875   72 LHDAVEEGDVKAVEELLDLGKFADD---VFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDI 148

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767916877  465 CIIialcrkdPSLLEAEATAENQ----CTPLLLAATSGALDTIQYLFSIGAN 512
Cdd:PHA02875  149 KGI-------ELLIDHKACLDIEdccgCTPLIIAMAKGDIAICKMLLDSGAN 193
Ank_2 pfam12796
Ankyrin repeats (3 copies);
491-541 2.83e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 41.25  E-value: 2.83e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767916877   491 LLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 541
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE 51
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 369-484 2.87e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 44.95  E-value: 2.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916877  369 TSSSTINVSDEAGYTIFHHAALHNRvSIICQLCNaNFKVNqrrfVTFSQGPTPLHLAAQ-ACSLETTVCLLCSKADYTLS 447
Cdd:PHA02874  211 DHGNHIMNKCKNGFTPLHNAIIHNR-SAIELLIN-NASIN----DQDIDGSTPLHHAINpPCDIDIIDILLYHKADISIK 284

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 767916877  448 EKRGWMPIHFAAFYDNvciiialcrKDPSLLEAEATA 484
Cdd:PHA02874  285 DNKGENPIDTAFKYIN---------KDPVIKDIIANA 312
Ank_4 pfam13637
Ankyrin repeats (many copies);
420-470 3.99e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.57  E-value: 3.99e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767916877   420 TPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIAL 470
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
Ank_2 pfam12796
Ankyrin repeats (3 copies);
374-446 4.98e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 40.48  E-value: 4.98e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767916877   374 INVSDEAGYTIFHHAALHNRVSIICQLCNanfKVNQRRfvtFSQGPTPLHLAAQACSLETTVCLLCSKADYTL 446
Cdd:pfam12796   23 ANLQDKNGRTALHLAAKNGHLEIVKLLLE---HADVNL---KDNGRTALHYAARSGHLEIVKLLLEKGADINV 89
Ank_5 pfam13857
Ankyrin repeats (many copies);
374-425 6.75e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.17  E-value: 6.75e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 767916877   374 INVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFvtfsQGPTPLHLA 425
Cdd:pfam13857    9 LNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDE----EGLTALDLA 56
HEAT COG1413
HEAT repeat [General function prediction only];
549-659 6.90e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 38.46  E-value: 6.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916877  549 VWKTLVEMLQCESYKRRMMAVMSLEVIClandqywrcilDAGTIPALINLLKSSKIKLQCKTVGLLSNISTHKS------ 622
Cdd:COG1413    17 AVPALIAALADEDPDVRAAAARALGRLG-----------DPRAVPALLEALKDPDPEVRAAAAEALGRIGDPEAvpalia 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767916877  623 ------------AVHALVEAGG---IPSLINLLVCDEPEVHSRCAVILYDIA 659
Cdd:COG1413    86 alkdedpevrraAAEALGRLGDpaaVPALLEALKDPDWEVRRAAARALGRLG 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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