NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767917985|ref|XP_011509423|]
View 

interleukin-1 receptor antagonist protein isoform X1 [Homo sapiens]

Protein Classification

beta-trefoil_IL1B domain-containing protein( domain architecture ID 10639008)

beta-trefoil_IL1B domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
beta-trefoil_IL1RA cd23297
beta-trefoil domain found in interleukin-1 receptor antagonist protein (IL-1RA) and similar ...
 1-142 7.38e-95

beta-trefoil domain found in interleukin-1 receptor antagonist protein (IL-1RA) and similar proteins; IL-1RA, also called IL-1RN, or IRAP, or ICIL-1RA, or IL1 inhibitor, inhibits the activity of interleukin-1 (IL-1) by binding to receptor IL1R1 and preventing its association with the co-receptor IL1RAP for signaling. It has no IL-1 like activity. IL-1RN binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unknown. IL-1RN contains a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


:

Pssm-ID: 466779  Cd Length: 149  Bit Score: 270.08  E-value: 7.38e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917985   1 MQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPI-----EPHALFLGIHGGKMCLSCVKSGDETRLQLEAVN 75
Cdd:cd23297    3 VFAYRIWDVNQKSLYLRNNQLVAGYLQGPNAALEEKIFWVPNrafepEPLPVILGIHDGSRCLSCVKSGDEPRLQLEDVD 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767917985  76 ITDLSENRKQDKRFAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQED 142
Cdd:cd23297   83 ITDLPRNGKQSARFTFFRSYRDGLWRFESAAHPGWFLCTSMRADQPVSLTNMPDEGVMVTDFYFQLC 149
 
Name Accession Description Interval E-value
beta-trefoil_IL1RA cd23297
beta-trefoil domain found in interleukin-1 receptor antagonist protein (IL-1RA) and similar ...
 1-142 7.38e-95

beta-trefoil domain found in interleukin-1 receptor antagonist protein (IL-1RA) and similar proteins; IL-1RA, also called IL-1RN, or IRAP, or ICIL-1RA, or IL1 inhibitor, inhibits the activity of interleukin-1 (IL-1) by binding to receptor IL1R1 and preventing its association with the co-receptor IL1RAP for signaling. It has no IL-1 like activity. IL-1RN binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unknown. IL-1RN contains a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466779  Cd Length: 149  Bit Score: 270.08  E-value: 7.38e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917985   1 MQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPI-----EPHALFLGIHGGKMCLSCVKSGDETRLQLEAVN 75
Cdd:cd23297    3 VFAYRIWDVNQKSLYLRNNQLVAGYLQGPNAALEEKIFWVPNrafepEPLPVILGIHDGSRCLSCVKSGDEPRLQLEDVD 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767917985  76 ITDLSENRKQDKRFAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQED 142
Cdd:cd23297   83 ITDLPRNGKQSARFTFFRSYRDGLWRFESAAHPGWFLCTSMRADQPVSLTNMPDEGVMVTDFYFQLC 149
IL1 smart00125
Interleukin-1 homologues; Cytokines with various biological functions. Interluekin 1 alpha and ...
 1-140 2.10e-74

Interleukin-1 homologues; Cytokines with various biological functions. Interluekin 1 alpha and beta are also known as hematopoietin and catabolin.


Pssm-ID: 128430  Cd Length: 147  Bit Score: 218.40  E-value: 2.10e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917985     1 MQAFRIWDVNQKTFYLRN-NQLVAGYLQGPNVNLEEKIDVVPIEPHA------LFLGIHGGKMCLSCVKSGDETRLQLEA 73
Cdd:smart00125   3 SQECRLNDANQKSLVLSNpQYLKALHLNGQNLNQEVKFDMSFVQGEEddskipVTLGISGTNLYLSCVKKGDEPTLQLEM 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767917985    74 VNITDLSEnRKQDKRFAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDeGVMVTKFYFQ 140
Cdd:smart00125  83 VDPPKYPK-KEMEKRFVFEKHEIGNKVEFESAAHPNWFISTSQEEDKPVFLGNGPP-SQDITDFQME 147
IL1 pfam00340
Interleukin-1 / 18; This family includes interleukin-1 and interleukin-18.
 26-139 7.66e-53

Interleukin-1 / 18; This family includes interleukin-1 and interleukin-18.


Pssm-ID: 395269  Cd Length: 119  Bit Score: 163.00  E-value: 7.66e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917985   26 LQGPNVNLEEKIDVVPIE--------PHALflGIHGGKMCLSCVKSgDETRLQLEAVNITDLSENRKQDKRFAFIRSDSG 97
Cdd:pfam00340   1 LQGQNLNLEVKFDMSFYKgdsddskiPVTL--GIKGKKLYLSCVNK-DEPVLQLEEVNIPKLIKNKESDKRFFFIRSESK 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 767917985   98 PTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYF 139
Cdd:pfam00340  78 NYVEFESAAYPGWFIATKQEEDLPVFLVNTAGGQDSITDFQI 119
PHA02651 PHA02651
IL-1 receptor antagonist; Provisional
 1-142 4.59e-38

IL-1 receptor antagonist; Provisional


Pssm-ID: 165031  Cd Length: 165  Bit Score: 127.07  E-value: 4.59e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917985   1 MQAFRIWDVNQKTFYLRNNQLVAGYLQgpNVNLEEKIDVVPIEPHALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLS 80
Cdd:PHA02651  22 MFMYNIWDVNQKIFYLRNNQLVAGHIQ--DNSLAEKITAKLIDGNDIFLGVKNGEKSLECTEHGDKVTLSLSDKKTNSLD 99

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767917985  81 ENrkQDKRFAFIRSDSGPTTSFESAACPGWFLCTAM-EADQPVSLT-----NMPDEGVMVTKFYFQED 142
Cdd:PHA02651 100 EN--QDKRFAFIRSDNGHTSTFESVAFPGWFLCTSSgDGIEPVGLTykgdkDDNDDDENNIYFYFEED 165
 
Name Accession Description Interval E-value
beta-trefoil_IL1RA cd23297
beta-trefoil domain found in interleukin-1 receptor antagonist protein (IL-1RA) and similar ...
 1-142 7.38e-95

beta-trefoil domain found in interleukin-1 receptor antagonist protein (IL-1RA) and similar proteins; IL-1RA, also called IL-1RN, or IRAP, or ICIL-1RA, or IL1 inhibitor, inhibits the activity of interleukin-1 (IL-1) by binding to receptor IL1R1 and preventing its association with the co-receptor IL1RAP for signaling. It has no IL-1 like activity. IL-1RN binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unknown. IL-1RN contains a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466779  Cd Length: 149  Bit Score: 270.08  E-value: 7.38e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917985   1 MQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPI-----EPHALFLGIHGGKMCLSCVKSGDETRLQLEAVN 75
Cdd:cd23297    3 VFAYRIWDVNQKSLYLRNNQLVAGYLQGPNAALEEKIFWVPNrafepEPLPVILGIHDGSRCLSCVKSGDEPRLQLEDVD 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767917985  76 ITDLSENRKQDKRFAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQED 142
Cdd:cd23297   83 ITDLPRNGKQSARFTFFRSYRDGLWRFESAAHPGWFLCTSMRADQPVSLTNMPDEGVMVTDFYFQLC 149
IL1 smart00125
Interleukin-1 homologues; Cytokines with various biological functions. Interluekin 1 alpha and ...
 1-140 2.10e-74

Interleukin-1 homologues; Cytokines with various biological functions. Interluekin 1 alpha and beta are also known as hematopoietin and catabolin.


Pssm-ID: 128430  Cd Length: 147  Bit Score: 218.40  E-value: 2.10e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917985     1 MQAFRIWDVNQKTFYLRN-NQLVAGYLQGPNVNLEEKIDVVPIEPHA------LFLGIHGGKMCLSCVKSGDETRLQLEA 73
Cdd:smart00125   3 SQECRLNDANQKSLVLSNpQYLKALHLNGQNLNQEVKFDMSFVQGEEddskipVTLGISGTNLYLSCVKKGDEPTLQLEM 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767917985    74 VNITDLSEnRKQDKRFAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDeGVMVTKFYFQ 140
Cdd:smart00125  83 VDPPKYPK-KEMEKRFVFEKHEIGNKVEFESAAHPNWFISTSQEEDKPVFLGNGPP-SQDITDFQME 147
beta-trefoil_IL36RA cd23303
beta-trefoil domain found in interleukin-36 receptor antagonist protein (IL-36RA) and similar ...
 4-140 2.49e-54

beta-trefoil domain found in interleukin-36 receptor antagonist protein (IL-36RA) and similar proteins; IL-36RA, also called FIL1 delta, or IL-1-related protein 3, or IL-1RP3, or interleukin-1 HY1, or IL-1HY1, or interleukin-1 delta, or IL-1 delta, or interleukin-1 family member 5, or IL-1F5, or interleukin-1 receptor antagonist homolog 1, or IL-1ra homolog 1, or interleukin-1-like protein 1, or IL-1L1, inhibits the activity of interleukin-36 (IL36 alpha,IL36 beta and IL36 gamma) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. It is part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; like the IL-1 system with which it shares the coreceptor. It may play a role in skin inflammation, as well as in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. It may activate an anti-inflammatory signaling pathway by recruiting SIGIRR. IL-36RA contains a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466785  Cd Length: 146  Bit Score: 167.61  E-value: 2.49e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917985   4 FRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVP---IEPH--ALFLGIHGGKMCLSCvKSGDETRLQLEAVNITD 78
Cdd:cd23303    5 FRMRDTALKVLYLHNNQLVAGGLHAGKNIKGEEISVVPnrfLDRRlsPIILGVQGGSQCLSC-GTGQEPTLQLEPVNIMD 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767917985  79 LSENRKQDKRFAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVmVTKFYFQ 140
Cdd:cd23303   84 LYLSAKEAKSFTFYRTDMGLTHRFESAAYPGWFLCTSPEADQPVRLTNRLGEAP-ITDFYFQ 144
IL1 pfam00340
Interleukin-1 / 18; This family includes interleukin-1 and interleukin-18.
 26-139 7.66e-53

Interleukin-1 / 18; This family includes interleukin-1 and interleukin-18.


Pssm-ID: 395269  Cd Length: 119  Bit Score: 163.00  E-value: 7.66e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917985   26 LQGPNVNLEEKIDVVPIE--------PHALflGIHGGKMCLSCVKSgDETRLQLEAVNITDLSENRKQDKRFAFIRSDSG 97
Cdd:pfam00340   1 LQGQNLNLEVKFDMSFYKgdsddskiPVTL--GIKGKKLYLSCVNK-DEPVLQLEEVNIPKLIKNKESDKRFFFIRSESK 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 767917985   98 PTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYF 139
Cdd:pfam00340  78 NYVEFESAAYPGWFIATKQEEDLPVFLVNTAGGQDSITDFQI 119
beta-trefoil_IL1 cd00100
beta-trefoil domain found in the interleukin-1 (IL-1) family of cytokines; The IL-1 family of ...
 1-139 5.29e-44

beta-trefoil domain found in the interleukin-1 (IL-1) family of cytokines; The IL-1 family of cytokines comprises 11 members, including 7 pro-inflammatory agonists (IL-1alpha, IL-1beta, IL-18, IL-33, IL-36alpha, IL-36beta, IL-36gamma) and 4 defined or putative antagonists (IL-1R antagonist (IL-1Ra), IL-36Ra, IL-37, and IL-38) exerting anti-inflammatory activities. These members can have complimentary or distinct biological functions. All family members share a common structure at the C-terminus, which is comprised by of a typical beta-trefoil fold consisting of 12-beta-strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466776  Cd Length: 145  Bit Score: 141.30  E-value: 5.29e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917985   1 MQAFRIWDVNQKTFYLR-NNQLVAGYLQgpNVNLEEKIDVVPIEP--------HALFLGIHGGKMCLSCVKSGDETRLQL 71
Cdd:cd00100    2 KRNFVIRDSNDKSLYLRgNNELVAEDLS--DVEKSAKITIYYYKSdsdedfkgIPVVLNFTGTNCFLSCVKEGDKPSLQL 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767917985  72 EAVNITDLSENRKQDKRFAFIRSDS-GPTTSFESAACPGWFLCTAMeaDQPVSLTNMPDeGVMVTKFYF 139
Cdd:cd00100   80 EECNKEELKNGDEEEWPFVFYMKAShDNTCRFESAAHPGWFICTKK--DQPVGLTKELG-KTEDTDFYF 145
PHA02651 PHA02651
IL-1 receptor antagonist; Provisional
 1-142 4.59e-38

IL-1 receptor antagonist; Provisional


Pssm-ID: 165031  Cd Length: 165  Bit Score: 127.07  E-value: 4.59e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917985   1 MQAFRIWDVNQKTFYLRNNQLVAGYLQgpNVNLEEKIDVVPIEPHALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLS 80
Cdd:PHA02651  22 MFMYNIWDVNQKIFYLRNNQLVAGHIQ--DNSLAEKITAKLIDGNDIFLGVKNGEKSLECTEHGDKVTLSLSDKKTNSLD 99

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767917985  81 ENrkQDKRFAFIRSDSGPTTSFESAACPGWFLCTAM-EADQPVSLT-----NMPDEGVMVTKFYFQED 142
Cdd:PHA02651 100 EN--QDKRFAFIRSDNGHTSTFESVAFPGWFLCTSSgDGIEPVGLTykgdkDDNDDDENNIYFYFEED 165
beta-trefoil_IL1B cd23296
beta-trefoil domain found in interleukin-1 beta (IL-1 beta) and similar proteins; IL-1 beta, ...
 1-130 1.30e-37

beta-trefoil domain found in interleukin-1 beta (IL-1 beta) and similar proteins; IL-1 beta, also called catabolin, is a potent inflammatory cytokine that activates the inflammatory process. It was initially discovered as the major endogenous pyrogen. It induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. IL-1 beta promotes Th17 differentiation of T-cells and synergizes with IL12/interleukin-12 to induce IFN-gamma synthesis from T-helper 1 (Th1) cells. It plays a role in angiogenesis by inducing vascular endothelial growth factor (VEGF) production synergistically with tumor necrosis factor (TNF) and IL-6. IL-1 beta contains a C-terminal beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466778  Cd Length: 150  Bit Score: 125.04  E-value: 1.30e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917985   1 MQAFRIWDVNQKTFYLRNN-QLVAGYLQGPNVNLEEKIDVV---------PIEPHALflGIHGGKMCLSCVKSGDETRLQ 70
Cdd:cd23296    4 SLSCTIRDSEQKSLVLSGPyQLVALHLQGPNSSQEVKLNMSfyrspesngGKIPVAL--GIKGKNLYLSCVKKGDKPTLQ 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767917985  71 LEAVNITDLSENrKQDKRFAFIRSDSGP-TTSFESAACPGWFLCTAMEADQPVSLTNMPDE 130
Cdd:cd23296   82 LEEVDPKNDSKS-KDLKRFLFYKIESIGsTTTFESAAFPGWYISTSQAENQPVFLGNQKGQ 141
beta-trefoil_IL38 cd23302
beta-trefoil domain found in interleukin-38 (IL-38) and similar proteins; IL-38, also called ...
 6-141 1.12e-32

beta-trefoil domain found in interleukin-38 (IL-38) and similar proteins; IL-38, also called interleukin-1 family member 10, or IL-1F10, or family of interleukin 1-theta, or FIL1 theta, or interleukin-1 HY2, or IL-1HY2, or interleukin-1 theta, or IL-1 theta, acts as cytokine with immunomodulatory activity. Alone, it does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. It also reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. It increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). IL-38 contains a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466784  Cd Length: 149  Bit Score: 112.83  E-value: 1.12e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917985   6 IWDVNQKTFYLRNNQLVAGYLQGPNVNlEEKIDVVPIE-----PHALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLS 80
Cdd:cd23302   10 IKYADQKALYTRDGQLLVGDPVADNCC-AEKICILPNRgldrtKVPIFLGIQGGSRCLACVETEEGPSLQLEDVNIEELY 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767917985  81 ENRKQDKRFAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNmPDEGVMVTKFYFQE 141
Cdd:cd23302   89 KGGEEATRFTFFQSSSGSAFRLEAAAWPGWFLCGPAEPQQPVQLTK-ESEPSARTKFYFEQ 148
beta-trefoil_IL36 cd23300
beta-trefoil domain found in the family of interleukin-36 (IL-36) and similar proteins; The ...
 4-140 4.92e-31

beta-trefoil domain found in the family of interleukin-36 (IL-36) and similar proteins; The IL-36 family includes three members, IL-36 alpha (also called FIL1 epsilon, or interleukin-1 epsilon, or IL-1 epsilon, or interleukin-1 family member 6, or IL-1F6), IL-36 beta (also called FIL1 eta, or interleukin-1 eta, or IL-1 eta, or interleukin-1 family member 8, or IL-1F8, or interleukin-1 homolog 2, or IL-1H2), and IL-36 gamma (also called IL-1-related protein 2, or IL-1RP2, or interleukin-1 epsilon, or IL-1 epsilon, or interleukin-1 family member 9, or IL-1F9, or interleukin-1 homolog 1, or IL-1H1). They act as cytokines that bind to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. They are parts of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; like the IL-1 system with which they share the co-receptor IL1RAP. They may be involved in skin inflammatory response by acting on keratinocytes, dendritic cells, and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. Members in this family contain a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466782  Cd Length: 148  Bit Score: 108.53  E-value: 4.92e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917985   4 FRIWDVNQKTFYLRNNQLVAGYLqgpnvnleeKIDVVPIEPH----------------ALFLGIHGGKMCLSCVKSGDET 67
Cdd:cd23300    5 RHIRDLNQQVWVLQGNTLIAVPR---------SDNVTPVTLAlipcrdteflekdkgnPIYLGIKGPELCLFCEEIGGQP 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767917985  68 RLQLEAVNITDLSENRKQDKRFAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVmVTKFYFQ 140
Cdd:cd23300   76 TLQLKEKNIMDLYNEPEAVKPFLFYHNQTGSTSTFESAAYPGWFIASSSEGGQPIILTKERGKTY-NTNFYLD 147
beta-trefoil_IL37 cd23301
beta-trefoil domain found in interleukin-37 (IL-37) and similar proteins; IL-37, also called ...
 2-125 4.87e-18

beta-trefoil domain found in interleukin-37 (IL-37) and similar proteins; IL-37, also called FIL1 zeta, or IL-1X, or interleukin-1 family member 7, or IL-1F7, or interleukin-1 homolog 4, or IL-1H, or IL-1H4, or interleukin-1 zeta, or IL-1 zeta, or interleukin-1-related protein, or IL-1RP1, or interleukin-23, or IL-23, acts as a suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. It suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A, and IL1RN, but spares anti-inflammatory cytokines and inhibits dendritic cell activation. IL-37 contains a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466783  Cd Length: 151  Bit Score: 75.15  E-value: 4.87e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917985   2 QAFRIWDVNQKTFYLRNNQLVAgyLQGPNVNLEEKIDVVP--------IEPHALFLGIHGGKMCLSC--VKSGDETRLQL 71
Cdd:cd23301    4 KKFIIRDTNQQVLVLDSGNLVA--VPDKSYIKPETFYVLAshlrsaseEKGNPIFLAVSKGELCLCCekVKGQKHPSLQL 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767917985  72 EAVNITDLSENRKQDKR-FAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLT 125
Cdd:cd23301   82 KKKKINELNSQKEKELLpFTFYKEKVGSYFTLESAANPGYFICTSNTPGQPVGVT 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH