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Conserved domains on  [gi|767918617|ref|XP_011509680|]
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semaphorin-4C isoform X1 [Homo sapiens]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 10181376)

immunoglobulin (Ig) domain-containing protein adopts a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and pattern recognition; similar to Drosophila melanogaster DIP/Dpr cell recognition proteins, which are members of the Wirin family of IgSF proteins with neuronal wiring functions, and human IgLON proteins, a family of cell adhesion molecules

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Sema_4C cd11258
The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C); Sema4C acts as a ...
42-498 0e+00

The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C); Sema4C acts as a Plexin B2 ligand to regulate the development of cerebellar granule cells and to modulate ureteric branching in the developing kidney. The binding of Sema4C to Plexin B2 results the phosphorylation of downstream regulator ErbB-2 and the plexin protein itself. The cytoplasmic region of Sema4C binds a neurite-outgrowth-related protein SFAP75, suggesting that Sema4C may also play a role in neural function. Sema4C belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


:

Pssm-ID: 200519 [Multi-domain]  Cd Length: 458  Bit Score: 927.29  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  42 VRRFSQTGIQDFLTLTLTEPTGLLYVGAREALFAFSMEALELQGAISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYN 121
Cdd:cd11258    1 VRRFSQVGVSNYTTLTLAEHRGLLYVGAREAIFALSLSNIELQPPISWEAPAEKKTECAQKGKSNQTECFNYIRFLQPYN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 122 ASHLYVCGTYAFQPKCTYVNMLTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNMGPHHSM 201
Cdd:cd11258   81 QSHLYTCGTYAFQPKCAYINMLTFTLDRAEFEDGKGKCPYDPAKGHTGLIVDGELYSATLNNFLGTEPVILRNLGQHYSM 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 202 KTEYLAFWLNEPHFVGSAYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQRKWTTFLKA 281
Cdd:cd11258  161 KTEYLAFWLNEPHFVGSAFVPESVGSFTGDDDKIYFFFSERAVEYDCDSEQVVARVARVCKGDLGGARTLQKKWTTFLKA 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 282 RLACSAPNWQLYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYTDP 361
Cdd:cd11258  241 RLLCSIPEWQLYFNQLKAVFTLEGASWRNTTFFAVFQARWGDMDVSAVCEYQLGEIQQVFEGPYKEYSEQAQKWGRYTDP 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 362 VPSPRPGSCINNWHRRHGYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVADRVTGLDGATYTVLFI 441
Cdd:cd11258  321 VPSPRPGSCINNWHRDHGYTSSLELPDNTLNFVKKHPLMEDRVKPRLGRPLLVPCNSNFTHVVWTRVLGLDGETYSVLFI 400
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767918617 442 GTGDGWLLKAVSLGPWVHLIEELQLFDQEPMRSLVLSQS-KKLLFAGSRSQLVQLPVA 498
Cdd:cd11258  401 GTLDGWLIKAVSLGSWVHMIEELQVFDQEPPESLVVSQSsKKLLFAGSRSELLQLPWA 458
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
563-647 5.31e-20

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05872:

Pssm-ID: 472250  Cd Length: 86  Bit Score: 85.18  E-value: 5.31e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 563 KNITVVAGTDLVLPCHLSSNLAHARWTFGGRDLPAEQPGSFLydaRLQALVVMAAQPRHAGAYHCFSEEQGARLAAEGYL 642
Cdd:cd05872    4 KFRTVVAGADVVLPCQLRSNLASPVWLFNGTPLNAQFSYLRL---GTDGLLILVTSPEHSGTYRCYSEEEGFQQLVASYS 80

                 ....*
gi 767918617 643 VAVVA 647
Cdd:cd05872   81 LNVVE 85
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
499-528 6.35e-09

domain found in Plexins, Semaphorins and Integrins;


:

Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 52.16  E-value: 6.35e-09
                           10        20        30
                   ....*....|....*....|....*....|
gi 767918617   499 DCMKYRSCADCVLARDPYCAWSVNTSRCVA 528
Cdd:smart00423   1 RCSKYTSCSECLLARDPYCAWCSSQGRCTS 30
 
Name Accession Description Interval E-value
Sema_4C cd11258
The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C); Sema4C acts as a ...
42-498 0e+00

The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C); Sema4C acts as a Plexin B2 ligand to regulate the development of cerebellar granule cells and to modulate ureteric branching in the developing kidney. The binding of Sema4C to Plexin B2 results the phosphorylation of downstream regulator ErbB-2 and the plexin protein itself. The cytoplasmic region of Sema4C binds a neurite-outgrowth-related protein SFAP75, suggesting that Sema4C may also play a role in neural function. Sema4C belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200519 [Multi-domain]  Cd Length: 458  Bit Score: 927.29  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  42 VRRFSQTGIQDFLTLTLTEPTGLLYVGAREALFAFSMEALELQGAISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYN 121
Cdd:cd11258    1 VRRFSQVGVSNYTTLTLAEHRGLLYVGAREAIFALSLSNIELQPPISWEAPAEKKTECAQKGKSNQTECFNYIRFLQPYN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 122 ASHLYVCGTYAFQPKCTYVNMLTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNMGPHHSM 201
Cdd:cd11258   81 QSHLYTCGTYAFQPKCAYINMLTFTLDRAEFEDGKGKCPYDPAKGHTGLIVDGELYSATLNNFLGTEPVILRNLGQHYSM 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 202 KTEYLAFWLNEPHFVGSAYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQRKWTTFLKA 281
Cdd:cd11258  161 KTEYLAFWLNEPHFVGSAFVPESVGSFTGDDDKIYFFFSERAVEYDCDSEQVVARVARVCKGDLGGARTLQKKWTTFLKA 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 282 RLACSAPNWQLYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYTDP 361
Cdd:cd11258  241 RLLCSIPEWQLYFNQLKAVFTLEGASWRNTTFFAVFQARWGDMDVSAVCEYQLGEIQQVFEGPYKEYSEQAQKWGRYTDP 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 362 VPSPRPGSCINNWHRRHGYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVADRVTGLDGATYTVLFI 441
Cdd:cd11258  321 VPSPRPGSCINNWHRDHGYTSSLELPDNTLNFVKKHPLMEDRVKPRLGRPLLVPCNSNFTHVVWTRVLGLDGETYSVLFI 400
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767918617 442 GTGDGWLLKAVSLGPWVHLIEELQLFDQEPMRSLVLSQS-KKLLFAGSRSQLVQLPVA 498
Cdd:cd11258  401 GTLDGWLIKAVSLGSWVHMIEELQVFDQEPPESLVVSQSsKKLLFAGSRSELLQLPWA 458
Sema smart00630
semaphorin domain;
53-473 1.35e-144

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 431.41  E-value: 1.35e-144
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617    53 FLTLTLTEPTGLLYVGAREALFAFSMEALELQGA-ISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYNASHLYVCGTY 131
Cdd:smart00630   1 LQHLLLDEDNGTLYVGARNRLYQLSLNLILEAELkTGPVLSSPDCEECVSKGKDPPTDCVNYIRLLLDYNEDRLLVCGTN 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617   132 AFQPKCTYVNMltftlehgefedgkgkcpydpakghagllvdGELYSATLNNFLGTEPIILRNMGPHH-------SMKTE 204
Cdd:smart00630  81 AFQPVCRLRNL-------------------------------GELYVGTVADFSGSDPAIPRSLSVRRlkgtsgvSLRTV 129
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617   205 YLAF-WLNEPHFVGSAYvpesvgsftgDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQRKWTTFLKARL 283
Cdd:smart00630 130 LYDSkWLNEPNFVYAFE----------SGDFVYFFFRETAVEDDNCGKAVHSRVARVCKNDVGGPRSLDKKWTSFLKARL 199
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617   284 ACSAPNW-QLYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRY-TDP 361
Cdd:smart00630 200 ECSVPGEdPFYFNELQAAFLLPPGSESDDVLYGVFSTSSNPIPGSAVCAFSLSDINAVFNGPFKECETSTSQWLPYsRGK 279
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617   362 VPSPRPGSCINNWHrrhgytSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTN--FTHLVADRVTGldGATYTVL 439
Cdd:smart00630 280 VPYPRPGTCPNKPP------SSKDLPDETLNFIKSHPLMDEVVQPLTGRPLFVKTDSNylLTSIAVDRVAT--DGNYTVL 351
                          410       420       430
                   ....*....|....*....|....*....|....*....
gi 767918617   440 FIGTGDGWLLKAVSLGP----WVHLIEELQLF-DQEPMR 473
Cdd:smart00630 352 FLGTSDGRILKVVLSESssssESVVLEEISVFpDGSPIS 390
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
297-479 8.48e-70

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 227.92  E-value: 8.48e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  297 LQAMHTLQ--DTSWHNTTFFGVFQAQWGD-MYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYTDPVPSPRPGSCINN 373
Cdd:pfam01403   1 LQDVFVLKpgAGDALDTVLYGVFTTQWSNsIGGSAVCAFSLSDINAVFEGPFKEQEKSDSKWLPYTGKVPYPRPGTCIND 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  374 WHRrhgytssLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVADRVTGLDGaTYTVLFIGTGDGWLLKAVS 453
Cdd:pfam01403  81 PLR-------LDLPDSVLNFVKDHPLMDEAVQPVGGRPLLVRTGVRLTSIAVDRVQALDG-NYTVLFLGTDDGRLHKVVL 152
                         170       180
                  ....*....|....*....|....*...
gi 767918617  454 LGP-WVHLIEELQLFDQ-EPMRSLVLSQ 479
Cdd:pfam01403 153 VGSeESHIIEEIQVFPEpQPVLNLLLSS 180
Ig_Sema4B_like cd05872
Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B; The members here are ...
563-647 5.31e-20

Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B; The members here are composed of the immunoglobulin (Ig)-like domain of Sema4B and similar proteins. Sema4B is a Class IV semaphorin. Semaphorins are classified based on structural features additional to the Sema domain. Sema4B has extracellular Sema and Ig domains, a transmembrane domain, and a short cytoplasmic domain. Sema4B has been shown to preferentially regulate the development of the postsynaptic specialization at the glutamatergic synapses. This cytoplasmic domain includes a PDZ-binding motif upon which the synaptic localization of Sem4B is dependent. Sema4B is a ligand of CLCP1. CLCP1 was identified in an expression profiling analysis, which compared a highly metastic lung cancer subline with its low metastic parental line. Sema4B was shown to promote CLCP1 endocytosis and their interaction is a potential target for therapeutic intervention of metastasis.


Pssm-ID: 409456  Cd Length: 86  Bit Score: 85.18  E-value: 5.31e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 563 KNITVVAGTDLVLPCHLSSNLAHARWTFGGRDLPAEQPGSFLydaRLQALVVMAAQPRHAGAYHCFSEEQGARLAAEGYL 642
Cdd:cd05872    4 KFRTVVAGADVVLPCQLRSNLASPVWLFNGTPLNAQFSYLRL---GTDGLLILVTSPEHSGTYRCYSEEEGFQQLVASYS 80

                 ....*
gi 767918617 643 VAVVA 647
Cdd:cd05872   81 LNVVE 85
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
499-528 6.35e-09

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 52.16  E-value: 6.35e-09
                           10        20        30
                   ....*....|....*....|....*....|
gi 767918617   499 DCMKYRSCADCVLARDPYCAWSVNTSRCVA 528
Cdd:smart00423   1 RCSKYTSCSECLLARDPYCAWCSSQGRCTS 30
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
499-527 3.07e-08

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 50.40  E-value: 3.07e-08
                          10        20
                  ....*....|....*....|....*....
gi 767918617  499 DCMKYRSCADCVLARDPYCAWSVNTSRCV 527
Cdd:pfam01437   1 RCSQYTSCSSCLAARDPYCGWCSSEGRCV 29
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
562-627 1.43e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 41.34  E-value: 1.43e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767918617   562 PKNITVVAGTDLVLPCHLSSN-LAHARWTFGGRDLPAEQPG-SFLYDARLQALVVMAAQPRHAGAYHC 627
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSpPPEVTWYKQGGKLLAESGRfSVSRSGSTSTLTISNVTPEDSGTYTC 68
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
557-627 7.32e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 39.09  E-value: 7.32e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767918617  557 KVRPTPKNITVVAGTDLVLPCHLSSN-LAHARWTFGGRDLPAEQPGSFLYDARLQALVVMAAQPRHAGAYHC 627
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCEATGSpPPTITWYKNGEPISSGSTRSRSLSGSNSTLTISNVTRSDAGTYTC 74
 
Name Accession Description Interval E-value
Sema_4C cd11258
The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C); Sema4C acts as a ...
42-498 0e+00

The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C); Sema4C acts as a Plexin B2 ligand to regulate the development of cerebellar granule cells and to modulate ureteric branching in the developing kidney. The binding of Sema4C to Plexin B2 results the phosphorylation of downstream regulator ErbB-2 and the plexin protein itself. The cytoplasmic region of Sema4C binds a neurite-outgrowth-related protein SFAP75, suggesting that Sema4C may also play a role in neural function. Sema4C belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200519 [Multi-domain]  Cd Length: 458  Bit Score: 927.29  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  42 VRRFSQTGIQDFLTLTLTEPTGLLYVGAREALFAFSMEALELQGAISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYN 121
Cdd:cd11258    1 VRRFSQVGVSNYTTLTLAEHRGLLYVGAREAIFALSLSNIELQPPISWEAPAEKKTECAQKGKSNQTECFNYIRFLQPYN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 122 ASHLYVCGTYAFQPKCTYVNMLTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNMGPHHSM 201
Cdd:cd11258   81 QSHLYTCGTYAFQPKCAYINMLTFTLDRAEFEDGKGKCPYDPAKGHTGLIVDGELYSATLNNFLGTEPVILRNLGQHYSM 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 202 KTEYLAFWLNEPHFVGSAYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQRKWTTFLKA 281
Cdd:cd11258  161 KTEYLAFWLNEPHFVGSAFVPESVGSFTGDDDKIYFFFSERAVEYDCDSEQVVARVARVCKGDLGGARTLQKKWTTFLKA 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 282 RLACSAPNWQLYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYTDP 361
Cdd:cd11258  241 RLLCSIPEWQLYFNQLKAVFTLEGASWRNTTFFAVFQARWGDMDVSAVCEYQLGEIQQVFEGPYKEYSEQAQKWGRYTDP 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 362 VPSPRPGSCINNWHRRHGYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVADRVTGLDGATYTVLFI 441
Cdd:cd11258  321 VPSPRPGSCINNWHRDHGYTSSLELPDNTLNFVKKHPLMEDRVKPRLGRPLLVPCNSNFTHVVWTRVLGLDGETYSVLFI 400
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767918617 442 GTGDGWLLKAVSLGPWVHLIEELQLFDQEPMRSLVLSQS-KKLLFAGSRSQLVQLPVA 498
Cdd:cd11258  401 GTLDGWLIKAVSLGSWVHMIEELQVFDQEPPESLVVSQSsKKLLFAGSRSELLQLPWA 458
Sema_4 cd11240
The Sema domain, a protein interacting module, of class 4 semaphorins (Sema4); Class 4 ...
45-498 0e+00

The Sema domain, a protein interacting module, of class 4 semaphorins (Sema4); Class 4 semaphorins (Sema4s) are transmembrane regulator molecules involved in the development of the nervous system, immune response, cytoskeletal organization, angiogenesis, and cell-cell interactions. There are 7 distinct subfamilies in class 4 semaphorins, named 4A to 4G. Several class 4 subfamilies play important roles in the immune system and are called "immune semaphorins". Sema4A plays critical roles in T cell-DC interactions in the immune response. Sema4D/CD100, expressed by lymphocytes, promotes the aggregation and survival of B lymphocytes and inhibits cytokine-induced migration of immune cells in vitro. It is required for normal activation of B and T lymphocytes. Sema4B negatively regulates basophil functions through T cell-basophil contacts and significantly inhibits IL-4 and IL-6 production from basophils in response to various stimuli, including IL-3 and papain. Sema4s not only influence the activation state of cells but also modulate their migration and survival. The effects of Sema4s on nonlymphoid cells are mediated by plexin D1 and plexin Bs. The Sema4G and Sema4C genes are expressed in the developing cerebellar cortex and are involved in neural tube closure and development of cerebellar granules cells through receptor plexin B2. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200501 [Multi-domain]  Cd Length: 456  Bit Score: 789.68  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  45 FSQTGIQDFLTLTLTEPTGLLYVGAREALFAFSMEAL--ELQGAISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYNA 122
Cdd:cd11240    1 FSQEGIQNYSTLLLSEDEGTLYVGAREALFALNVSDIstELKDKIKWEASEDKKKECANKGKDNQTDCFNFIRILQFYNS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 123 SHLYVCGTYAFQPKCTYVNMLTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNMGPHHSMK 202
Cdd:cd11240   81 THLYVCGTFAFSPRCTYINLSDFSLSSIKFEDGKGRCPFDPAQRYTAIMVDGELYSATVNNFLGSEPVISRNHSEGNVLK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 203 TEYLAFWLNEPHFVGSAYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQRKWTTFLKAR 282
Cdd:cd11240  161 TENTLRWLNEPAFVGSAHIRESIDSPDGDDDKIYFFFTETAVEYDFYEKVTVSRVARVCKGDLGGQRTLQKKWTTFLKAQ 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 283 LACSAPNWQLYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYTDPV 362
Cdd:cd11240  241 LVCSQPDSGLPFNVLRDVFVLSPDSWDATIFYGVFTSQWNVSGLSAVCAYSLEDIKKVFSGKYKEFNRETSKWSRYTGPV 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 363 PSPRPGSCINNWHRRHGYTSSLELPDNILNFVKKHPLMEEQVGPRwSRPLLVKKGTNFTHLVADRVTGLDGATYTVLFIG 442
Cdd:cd11240  321 PDPRPGACITNSARSQGITSSLNLPDNVLTFVKDHPLMDEQVHPI-NRPLLVKSGVNYTRIAVHRVQALDGQTYTVLFLG 399
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767918617 443 TGDGWLLKAVSLGPWVHLIEELQLFDQ-EPMRSLVLSQSKKLLFAGSRSQLVQLPVA 498
Cdd:cd11240  400 TEDGFLHKAVSLDGGMHIIEEIQLFDQpQPVKNLLLSSSKGVLYVGSSSGVVQVPLS 456
Sema_4G cd11262
The Sema domain, a protein interacting module, of semaphorin 4G (Sema4G); The Sema4G and ...
43-497 0e+00

The Sema domain, a protein interacting module, of semaphorin 4G (Sema4G); The Sema4G and Sema4C genes are expressed in the developing cerebellar cortex. Sema4G and Sema4C proteins specifically bind to Plexin B2 expressed in the cerebellar granule cells. Sema4G and Sema4C are involved in neural tube closure and cerebellar granule cell development through Plexin B2.Sema4G belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200523 [Multi-domain]  Cd Length: 457  Bit Score: 585.19  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  43 RRFSqTGIQDFLTLTLTEPTGLLYVGAREALFAFSMEALE--LQGAISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPY 120
Cdd:cd11262    1 RRFR-GPAQNYSTLLLEDESGRLYVGARGAIFSLNASDISdsSALTIDWEASPEQKHQCLKKGKNNQTECFNHVRFLQRF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 121 NASHLYVCGTYAFQPKCTYVNMLTFTLEhGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTePIILRNMgPHHS 200
Cdd:cd11262   80 NSTHLYTCGTHAFRPLCAYIDAERFTLS-SQFEEGKEKCPYDPAKGYTGLIVDGQLYTASQYEFRSF-PDIRRNS-PQPT 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 201 MKTEYLAF-WLNEPHFVGSAYVPESVGSFTGDDDKVYFFFRERAVE-SDCYAEQVVARVARVCKGDMGGARTLQRKWTTF 278
Cdd:cd11262  157 LRTEEAPTrWLNDADFVGSVLVRESMNSSVGDDDKIYFFFTERSQEeTAYFSQSRVARVARVCKGDRGGKKTLQRKWTSF 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 279 LKARLACSAPNWQLYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRY 358
Cdd:cd11262  237 LKARLVCYIPEYEFLFNVLRSVFVLWGSTPQDTVFYGIFGLEWKNVKASAICRYSLSDIQTAFEGPYMEYQDSSSKWSRY 316
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 359 TDPVPSPRPGSCINNWHRRHGYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVADRVTGLDGATYTV 438
Cdd:cd11262  317 TGKVPEPRPGSCITDEHRSQGINSSQDLPDNVLDFVRRHPLMAEQVLPVEGRPLLFKRNVIYTKIAVQTVRGLDGRVYDV 396
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 439 LFIGTGDGWLLKAVSLGPWVHLIEELQLFDQ-EPMRSLVLSQSKKLLFAGSRSQLVQLPV 497
Cdd:cd11262  397 LFLGTDEGWLHKAVVIGSAVHIIEELQVFREpQPVENLVISKKQNSLYVGARSGVVQVPL 456
Sema_4B cd11257
The Sema domain, a protein interacting module, of semaphorin 4B (Sema4B); Sema4B, expressed in ...
44-498 3.23e-174

The Sema domain, a protein interacting module, of semaphorin 4B (Sema4B); Sema4B, expressed in T and B cells, is an immune semaphorin. It functions as a negative regulatory of basophils through T cell-basophil contacts and it significantly inhibits IL-4 and IL-6 production from basophils in response to various stimuli, including IL-3 and papain. In addition, T cell-derived Sema4B suppresses basophil-mediated Th2 skewing and humoral memory responses. Sema4B may be also involved in lung cancer cell mobility by inducing the degradation of CLCP1 (CUB, LCCL-homology, coagulation factor V/VIII homology domains protein). Sema4B is characterized by a PDZ-binding motif at the carboxy-terminus, which mediates interaction with the post-synaptic density protein PSD-95/SAP90, which is thought to play a central role during synaptogenesis and in the structure and function of post-synaptic specializations of excitatory synapses. Sema4B belongs to class 4 transmembrane semaphorin family proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200518 [Multi-domain]  Cd Length: 464  Bit Score: 510.56  E-value: 3.23e-174
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  44 RFSQTGIQDFLTLTLTEPTGLLYVGAREALFAFSMEAL---ELQGAISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPY 120
Cdd:cd11257    1 RFEAEGVSNYTALLLSKDGNMLYVGARETLFALSSNDIsptGEQQELTWSADEEKKQECSFKGKDPQRDCQNYIKILLRL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 121 NASHLYVCGTYAFQPKCTYVNMLTFTLEHGE-----FEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNM 195
Cdd:cd11257   81 NSTHLFTCGTYAFSPICTYIVMTNFSLERDEkgeplLEDGKGRCPFDPEYKSTAIMVDGELYTGTVSNFQGNDPIIYRSL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 196 GPHHSMKTEYLAFWLNEPHFVGSAYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQRKW 275
Cdd:cd11257  161 GSGTPLKTENSLNWLQDPAFVGSAYIQESLPKLVGDDDKIYFFFSETGKEFDFFENTIVSRIARVCKGDEGGERVLQKRW 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 276 TTFLKARLACSAPNWQLYFNQLQAMHTL--QDTSWHNTTFFGVFQAQW--GDMYLSAICEYQLEEIQRVFEGPYKEYHEE 351
Cdd:cd11257  241 TTFLKAQLLCSLPDDGFPFNVLQDVFVLtpSPEDWKDTLFYGVFTSQWhkGTAGSSAVCVFTMDQVQRAFNGLYKEVNRE 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 352 AQKWDRYTDPVPSPRPGSCINNWHRRHGYTSSLELPDNILNFVKKHPLMEEQVGprwSRPLLVKKGTNFTHLVADRVTGL 431
Cdd:cd11257  321 TQQWYTYTHPVPEPRPGACITNSARERKINSSLHMPDRVLNFVKDHFLMDGQVR---SQPLLLQPQVRYTQIAVHRVKGL 397
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767918617 432 DgATYTVLFIGTGDGWLLKAVSLGPWVHLIEELQLF-DQEPMRSLVLSQSKKLLFAGSRSQLVQLPVA 498
Cdd:cd11257  398 H-KTYDVLFLGTDDGRLHKAVSVGPMVHIIEELQIFsEGQPVQNLLLDTHKGLLYASSHSGVVQVPVA 464
Sema_4D cd11259
The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100); ...
45-498 3.96e-171

The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100); Sema4D/CD100 is expressed in immune cells and plays critical roles in immune response; it is thus termed an "immune semaphorin". It is expressed by lymphocytes and promotes the aggregation and survival of B lymphocytes and inhibits cytokine-induced migration of immune cells in vitro. Sema4D/CD100 knock-out mice demonstrate that Sema4D is required for normal activation of B and T lymphocytes. Sema4D increases B-cell and DC function using either Plexin B1 or CD72 as receptors. The function of Sema4D in immune response implicates its role in infectious and noninfectious diseases. Sema4D belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200520 [Multi-domain]  Cd Length: 471  Bit Score: 502.85  E-value: 3.96e-171
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  45 FSQTGIQDFLTLTLTEPTGLLYVGAREALFAFS-MEALELQGAISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYNAS 123
Cdd:cd11259   12 FHEPDVSNYSTLLLSEDKDVLYVGAREAVFALNaLNISEKQHELYWKVSEDKRTKCAVKGKSKQTECRNYIRVLQPLNDT 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 124 HLYVCGTYAFQPKCTYVNMLTFTLEhGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNMgPHHSMKT 203
Cdd:cd11259   92 FLYVCGTNAFQPTCDYLNLTSFRLL-GKNEDGKGRCPFDPAQSYTSVMVDGELYSGTSYNFLGSEPIISRNS-SQSPLRT 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 204 EYLAFWLNEPHFVGSAYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQRKWTTFLKARL 283
Cdd:cd11259  170 EYAIPWLNEPSFVFADVIRADPDSPDGEDDKIYFFFTEVSVEYEFVGKLLIPRIARVCKGDQGGLRTLQKKWTSFLKARL 249
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 284 ACSAPNWQLYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVF-EGPYKEYHEEAQ---KWDRYT 359
Cdd:cd11259  250 ICSIPDKNLVFNVVNDVFILKSPTLKEPVIYGVFTPQLNNVGLSAVCAYNLSTVEEVFsKGKYMQSATVEQshtKWVRYN 329
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 360 DPVPSPRPGSCINNWHRRHGYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVADRVTGLDGATYTVL 439
Cdd:cd11259  330 GEVPKPRPGACINNEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIGNRPRLIKKDVNYTQIVVDRVQALDGTIYDVM 409
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767918617 440 FIGTGDGWLLKAVSLGPWVHLIEELQLF-DQEPMRSLVLS--QSKKLLFAGSRSQLVQLPVA 498
Cdd:cd11259  410 FISTDRGALHKAISLENEVHIIEETQLFpDFEPVQTLLLSskKGRRFLYAGSNSGVVQSPLA 471
Sema_4E cd11260
The Sema domain, a protein interacting module, of semaphorin 4E (Sema4E); Sema4E is expressed ...
45-498 1.35e-159

The Sema domain, a protein interacting module, of semaphorin 4E (Sema4E); Sema4E is expressed in the epithelial cells that line the pharyngeal arches in zebrafish. It may act as a guidance molecule to restrict the branchiomotor axons to the mesenchymal cells. Gain-of-function and loss-of-function studies demonstrate that Sema4E is essential for the guidance of facial axons from the hindbrain into their pharyngeal arch targets and is sufficient for guidance of gill motor axons. Sema4E guides facial motor axons by a repulsive action. Sema4E belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200521 [Multi-domain]  Cd Length: 456  Bit Score: 472.85  E-value: 1.35e-159
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  45 FSQTGIQDFLTLTLTEPTGLLYVGAREALFAFSMEALELQGA-ISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYNAS 123
Cdd:cd11260    1 FKEQGIWNYSTMLLREDLGLLVLGAREAVFALDLNDISVKRAkVLWEVTEEKQKDCTNKGKHADIDCHNYIRILHKMNDS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 124 HLYVCGTYAFQPKCTYVNML--TFTLEhGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNmgPHHSM 201
Cdd:cd11260   81 RMYVCGTNAFSPTCDYISYDdgQLTLE-GKQEDGKGKCPFDPFQRYSSVMVDQDLYSATSMNFLGSEPVIMRS--SPITI 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 202 KTEYLAFWLNEPHFVGSAYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQRKWTTFLKA 281
Cdd:cd11260  158 RTEFKSSWLNEPNFIYMAAVPESEDSPEGDDDKIYLFFSETAVEYDFYNKLVVSRVARVCKGDLGGQRTLQKKWTSFLKA 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 282 RLACSAPNWQLYFNQLQAMHTLQDtSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVF-EGPYK-EYHEEAQ--KWDR 357
Cdd:cd11260  238 RLDCSVPEPSLPYVIQDVFHVCHQ-DWRKCVFYAVFTSQSDSSQSSAVCAYNVTDISNVFsRGKFKtPVAVETSfvKWVM 316
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 358 YTDPVPSPRPGSCINNWHRRHGYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVADRVTGLDGATYT 437
Cdd:cd11260  317 YSGELPVPRPGACINNAARTSGIKKSLNLPDKTLQFVKDKPLMDQAVHPITGKPLLVKRGALFTRIVVDMVTAADGQSYP 396
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767918617 438 VLFIGTGDGWLLKAVSLGPWVHLIEELQLFD-QEPMRSLVLSQskKLLFAGSRSQLVQLPVA 498
Cdd:cd11260  397 VMFIGTANGYVLKAVNYDGEMHIIEEVQLFEpEEPIDILRLSQ--NQLYAGSASGVVQMPVS 456
Sema_semaphorin cd11235
The Sema domain, a protein interacting module, of semaphorins; Semaphorins are regulator ...
52-498 2.04e-146

The Sema domain, a protein interacting module, of semaphorins; Semaphorins are regulator molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. They can be divided into 7 classes. Vertebrates have members in classes 3-7, whereas classes 1 and 2 are known only in invertebrates. Class 2 and 3 semaphorins are secreted proteins; classes 1 and 4 through 6 are transmembrane proteins; and class 7 is membrane associated via glycosylphosphatidylinositol (GPI) linkage. The semaphorins exert their function through their receptors, the neuropilin and plexin families. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200496 [Multi-domain]  Cd Length: 437  Bit Score: 438.00  E-value: 2.04e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  52 DFLTLTLTEPTGLLYVGAREALFAFSMEALELQGAISWEAPVEKKTECIQKGKNnQTECFNFIRFLQPYNASHLYVCGTY 131
Cdd:cd11235    2 KYHTKLLHEDRSTLYVGARDRVYLVDLDSLYTEQKVAWPSSPDDVDTCYLKGKS-KDDCRNFIKVLEKNSDDSLLVCGTN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 132 AFQPKCTYVNMLTFTLEhGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNMGPHHSMKTEY-LAFWL 210
Cdd:cd11235   81 AFNPSCRNYNVETFELV-GKEESGRGKCPYDPDHNSTALFADGELYSGTSADFLGTDPVIYRTLGHNPPLRTEYhDSKWL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 211 NEPHFVGSAYVPesvgsftgddDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQRKWTTFLKARLACSAP-N 289
Cdd:cd11235  160 NEPQFVGAFDIG----------DYVYFFFREIAVEYINCGKAVYSRVARVCKNDQGGSRSLEKKWTTFLKARLNCSVPgE 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 290 WQLYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYTD-PVPSPRPG 368
Cdd:cd11235  230 FPFYFNELQDVFDLPSPSNKEKIFYAVFTTPYNSIPGSAVCAYSLSDIEAVFNGPFKEQHSSNSAWLPVPDeRVPEPRPG 309
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 369 SCinnwhrrhgYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTN--FTHLVADRVTGLDGATYTVLFIGTGDG 446
Cdd:cd11235  310 TC---------VDDSSPLPDDTLNFIKSHPLMDEAVTPILNRPLFIKTDVNyrFTKIAVDRVQAKLGQTYDVLFVGTDRG 380
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767918617 447 WLLKAVSLGPW----VHLIEELQLFDQ-EPMRSLVLSQSKKLLFAGSRSQLVQLPVA 498
Cdd:cd11235  381 IILKVVSLPEQglqaSNILEEMPVGPPpEPIQTMQLSRKRRSLYVGSETGVLQVPLA 437
Sema smart00630
semaphorin domain;
53-473 1.35e-144

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 431.41  E-value: 1.35e-144
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617    53 FLTLTLTEPTGLLYVGAREALFAFSMEALELQGA-ISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYNASHLYVCGTY 131
Cdd:smart00630   1 LQHLLLDEDNGTLYVGARNRLYQLSLNLILEAELkTGPVLSSPDCEECVSKGKDPPTDCVNYIRLLLDYNEDRLLVCGTN 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617   132 AFQPKCTYVNMltftlehgefedgkgkcpydpakghagllvdGELYSATLNNFLGTEPIILRNMGPHH-------SMKTE 204
Cdd:smart00630  81 AFQPVCRLRNL-------------------------------GELYVGTVADFSGSDPAIPRSLSVRRlkgtsgvSLRTV 129
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617   205 YLAF-WLNEPHFVGSAYvpesvgsftgDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQRKWTTFLKARL 283
Cdd:smart00630 130 LYDSkWLNEPNFVYAFE----------SGDFVYFFFRETAVEDDNCGKAVHSRVARVCKNDVGGPRSLDKKWTSFLKARL 199
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617   284 ACSAPNW-QLYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRY-TDP 361
Cdd:smart00630 200 ECSVPGEdPFYFNELQAAFLLPPGSESDDVLYGVFSTSSNPIPGSAVCAFSLSDINAVFNGPFKECETSTSQWLPYsRGK 279
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617   362 VPSPRPGSCINNWHrrhgytSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTN--FTHLVADRVTGldGATYTVL 439
Cdd:smart00630 280 VPYPRPGTCPNKPP------SSKDLPDETLNFIKSHPLMDEVVQPLTGRPLFVKTDSNylLTSIAVDRVAT--DGNYTVL 351
                          410       420       430
                   ....*....|....*....|....*....|....*....
gi 767918617   440 FIGTGDGWLLKAVSLGP----WVHLIEELQLF-DQEPMR 473
Cdd:smart00630 352 FLGTSDGRILKVVLSESssssESVVLEEISVFpDGSPIS 390
Sema_3 cd11239
The Sema domain, a protein interacting module, of class 3 semaphorins; Class 3 semaphorins ...
49-500 3.76e-143

The Sema domain, a protein interacting module, of class 3 semaphorins; Class 3 semaphorins (Sema3s) are secreted regulator molecules involved in the development of the nervous system, vasculogenesis, angiogenesis,and tumorigenesis. There are 7 distinct subfamilies named Sema3A to 3G. Sema3s function as repellent signals during axon guidance by repelling neurons away from the source of Sema3s. However, Sema3s that are secreted by tumor cells play an inhibitory role in tumor growth and angiogenesis (specifically Sema3B and Sema3F). Sema3s functions by forming complexes with neuropilins and A-type plexins, where neuropilins serve as the ligand binding moiety and the plexins function as signal transduction component. Sema3s primarily inhibit the cell motility and migration of tumor and endothelial cells by inducing collapse of the actin cytoskeleton via neuropilins and plexins. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200500 [Multi-domain]  Cd Length: 471  Bit Score: 431.01  E-value: 3.76e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  49 GIQDFLTLTLTEPTGLLYVGAREALFAFSMEALELQG-AISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYNASHLYV 127
Cdd:cd11239    6 NSLDYRSLLLDEDRDRLYVGGKDHILSLSLDNINQDPkKIYWPASPERIEECKMAGKDPNTECANFVRVLQPYNRTHLYA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 128 CGTYAFQPKCTYVNM------LTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNMGPHHSM 201
Cdd:cd11239   86 CGTGAFHPICAFINVgrrledPIFKLDDSSLESGRGKCPFDPNQPFASVLIDGELYSGTAIDFMGRDAAIFRSLGHRHYI 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 202 KTE-YLAFWLNEPHFVGSAYVPESvgsFTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQRKWTTFLK 280
Cdd:cd11239  166 RTEqYDSRWLNEPKFVGAYLIPDS---DNPDDDKVYFFFREKAVEAEGSGKAIYSRVGRICKNDVGGQRSLVNKWSTFLK 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 281 ARLACSAPN---WQLYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPY--KEYHEeaQKW 355
Cdd:cd11239  243 ARLVCSVPGpdgIDTYFDELEDVFLLPTRDPKNPLIYGVFTTSSNVFKGSAVCVYSMADIRAAFNGPFahKEGPN--YQW 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 356 DRYTDPVPSPRPGSCINNWHRRhGYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTN--FTHLVADRVTGLDG 433
Cdd:cd11239  321 VEYQGKVPYPRPGTCPSKTYGP-LYKSTKDFPDDVISFARSHPLMYNPVYPLHGRPLLIRTNVPyrLTQIAVDRVEAEDG 399
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767918617 434 aTYTVLFIGTGDGWLLKAVSL--GPWVH---LIEELQLF-DQEPMRSLVLSQSKKLLFAGSRSQLVQLPVADC 500
Cdd:cd11239  400 -QYDVLFIGTDSGTVLKVVSLpkENWEMeevILEELQVFkHPSPITSMEISSKRQQLYVGSAEGVVQLPLHRC 471
Sema_4A cd11256
The Sema domain, a protein interacting module, of semaphorin 4A (Sema4A); Sema4A is expressed ...
44-521 6.01e-142

The Sema domain, a protein interacting module, of semaphorin 4A (Sema4A); Sema4A is expressed in immune cells and is thus termed an "immune semaphorin". It plays critical roles in T cell-DC interactions in the immune response. It has been reported to enhance activation and differentiation of T cells in vitro and generation of antigen-specific T cells in vivo. The function of Sema4A in the immune response implicates its role in infectious and noninfectious diseases. Sema4A exerts its function through three receptors, namely Plexin B, Plexin D1, and Tim-2. Sema4A belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. TThe Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200517 [Multi-domain]  Cd Length: 447  Bit Score: 427.02  E-value: 6.01e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  44 RFSQTGIQDFLTLTLTEPTGLLYVGAREALFAFSME---ALELQGAISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPY 120
Cdd:cd11256    1 RFRQENVHNYDQLLLSPDETTLYVGARDNILALGIRtpgPIRLKHQIPWPANDSKISECAFKKKSNETECFNFIRVLVPV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 121 NASHLYVCGTYAFQPKCTYVNMLTFTL--EHGE--FEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNMG 196
Cdd:cd11256   81 NGTHLYTCGTYAFSPACTYIELDHFSLppPNGTiiTMDGKGQSPFDPQHNYTAILVDGELYTGTMNNFRGNEPIIFRNLG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 197 PHHSMKTEYLAFWLN-EPHFVGSAYVPEsvgsftgdDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQRKW 275
Cdd:cd11256  161 TKVSLKTDGFLRWLNaDAVFVASFNPQG--------DSKVYFFFEETAREFDFFEKLTVARVARVCKNDVGGEKLLQKKW 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 276 TTFLKARLACSAPNwQLYFNQLQAMHTLQDTSWHNTTFFGVFQAQW--GDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQ 353
Cdd:cd11256  233 TTFLKAQLTCSQQG-HFPFNVIHHVALLNQPDPNNSVFYAVFTSQWqlGGRRSSAVCAYKLNDIEKVFNGKYKELNKESS 311
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 354 KWDRYTDPVPSPRPGSCinnwhrrhgytSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVADRVTGLDG 433
Cdd:cd11256  312 RWTRYMGPVSDPRPGSC-----------SGGKSSDKALNFMKDHFLMDEVVLPGAGRPLLVKSNVQYTRIAVDSVQGVSG 380
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 434 ATYTVLFIGTGDGWLLKAVSLGPWV-HLIEELQLF-DQEPMRSLVLSQSKkllfagsrsqlvqlpvadcmkyrscaDCVL 511
Cdd:cd11256  381 HNYTVMFLGTDKGFLHKAVLMGGSEsHIIEEIELLtPPEPVENLLLAANE--------------------------GVVY 434
                        490
                 ....*....|
gi 767918617 512 ARDPYCAWSV 521
Cdd:cd11256  435 IGYSAGVWRV 444
Sema_4F cd11261
The Sema domain, a protein interacting module, of semaphorin 4F (Sema4F); Sema4F plays role in ...
44-498 1.08e-140

The Sema domain, a protein interacting module, of semaphorin 4F (Sema4F); Sema4F plays role in heterotypic cell-cell contacts and controls cell proliferation and suppresses tumorigenesis. In neurofibromatosis type 1 (NF1) patients, reduced Sema4F level disrupts Schwann cell/axonal interactions. Experiments using a yeast two-hybrid system show that the extreme C-terminus of Sema4F interacts with the PDZ domains of post-synaptic density protein SAP90/PSD-95, indicating possible functional involvement of Semas4F at glutamatergic synapses. Recent work also suggests a role for Sema4F in the injury response of intramedullary axotomized motoneuron. Sema4F belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulator molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200522 [Multi-domain]  Cd Length: 460  Bit Score: 424.30  E-value: 1.08e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  44 RFSQTGIQDFLTLTLTEPTGLLYVGAREALFAFSMEALELQGA-ISWEAPVEKKTECIQKGKNnQTECFNFIRFLQPYNA 122
Cdd:cd11261    5 RFSAPHTYNYSVLLVDPASHTLYVGARDAIFALTLPFSGERPRrIDWMVPEAHRQNCRKKGKK-EAECHNFIRILAIANA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 123 SHLYVCGTYAFQPKCTYVNMLTF-TLEHgeFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNMG-PHHS 200
Cdd:cd11261   84 SHLLTCGTFAFDPKCGVIDVSSFqQVER--LESGRGKCPFEPAQRSAAIMAGGVLYAATVKNFLGTEPIISRAVGrAEEW 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 201 MKTEYLAFWLNEPHFVGSAYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQRKWTTFLK 280
Cdd:cd11261  162 IRTETLPSWLNAPAFVAAVFLSPAEWGDEDGDDEIYFFFTETAREYDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLK 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 281 ARLACSAPNWQLYFNQLQAMHTLQDTSWHNTT-FFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYT 359
Cdd:cd11261  242 ADLLCPGPEHGRASSILQDVTTLRPLPGAGTPiFYGIFSSQWEGASISAVCAFRPQDIRRVMNGPFREFKHDCNRGLPVM 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 360 DP-VPSPRPGSCINNWHRRHGYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVADRVTGLDGATYTV 438
Cdd:cd11261  322 DSdVPQPRPGECITNNMKLLGFGSSLSLPDRVLTFVRDHPLMDRPVFPADGHPLLVTTDTAYLRVAAHRVTSLSGKEYDV 401
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767918617 439 LFIGTGDGWLLKAVSLGPWVHLIEELQLF-DQEPMRSLVLSQSkkLLFAGSRSQLVQLPVA 498
Cdd:cd11261  402 LYLGTEDGHLHRAVRIGAQLSVLEDLALFpEPQPVENLQLHHN--WLLVGSDTEVTQINTS 460
Sema_3B cd11250
The Sema domain, a protein interacting module, of semaphorin 3B (Sema3B); Sema3B is ...
53-500 1.31e-120

The Sema domain, a protein interacting module, of semaphorin 3B (Sema3B); Sema3B is coexpressed with semaphorin 3F and both proteins are candidate tumor suppressors. Both Sema3B and Sema3F show high levels of expression in normal tissues and low-grade tumors but are down-regulated in highly metastatic tumors in the lung, melanoma cells, bladder carcinoma cells and prostate carcinoma. They are upregulated by estrogen and inhibit cell motility and invasiveness through decreased FAK phosphorylation and inhibition of MMP-2 and MMP-9 expression. Two receptor families, the neuropilins (NP) and plexins, have been implicated in mediating the actions of semaphorins 3B and 3F. Sema3B is a member of the class 3 semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200511 [Multi-domain]  Cd Length: 471  Bit Score: 372.71  E-value: 1.31e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  53 FLTLTLTEPTGLLYVGAREALFAFSMEALELQG-AISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYNASHLYVCGTY 131
Cdd:cd11250   10 YDALLLDEERGRLFVGAKNYLASLSLDNISKQEkKIYWPAPVEWREECNWAGKDINTDCMNYVKILHHYNRTHLYACGTG 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 132 AFQPKCTYVNM------LTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNMGPHHSMKTE- 204
Cdd:cd11250   90 AFHPTCAFVEVgqrmedHVFRLDPSRVEDGKGKSPYDPRHTAASVLVGDELYSGVATDLMGRDFTIFRSLGQRPSLRTEq 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 205 YLAFWLNEPHFVGSAYVPESVGSftgDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQRKWTTFLKARLA 284
Cdd:cd11250  170 HDSRWLNEPKFVKVFWIPESENP---DDDKIYFFFRETAVEAAGLGKQSYSRIGQICRNDMGGQRSLVNKWTTFLKARLV 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 285 CSAPNWQL---YFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYTDP 361
Cdd:cd11250  247 CSVPGNEGgdtHFDELRDVFLLQTRDKRNPLIYAVFSTSSSVFQGSAVCVYTMNDVRRAFLGPFAHKEGPNYQWVSYQGK 326
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 362 VPSPRPGSCINnwhRRHG-YTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTN--FTHLVADRVTGLDGAtYTV 438
Cdd:cd11250  327 VPYPRPGMCPS---KTFGsFESTKDFPDDVIQFARNHPLMFNPVLPLGGRPLFLRTGIPytFTQIAVDRVAAADGH-YDV 402
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767918617 439 LFIGTGDGWLLKAVSL--GPWVH----LIEELQLF-DQEPMRSLVLSQSKKLLFAGSRSQLVQLPVADC 500
Cdd:cd11250  403 MFIGTDVGSVLKVISVpkGSWPSneelLLEELHVFkDSSPITSMQISSKRQQLYVGSRSGVSQLPLHRC 471
Sema_3A cd11249
The Sema domain, a protein interacting module, of semaphorin 3A (Sema3A); Sema3A has been ...
26-500 1.35e-120

The Sema domain, a protein interacting module, of semaphorin 3A (Sema3A); Sema3A has been reported to inhibit the growth of certain experimental tumors and to regulate endothelial cell migration and apoptosis in vitro, as well as arteriogenesis in the muscle, skin vessel permeability, and tumor angiogenesis in vivo. The function of Sema3A is mediated through receptors neuropilin-1 (NP1) and plexins, although little is known about the requirement of specific plexins in its receptor complex. It is known however that Plexin-A4 is the receptor for Sema3A in the Toll-like receptor- and sepsis-induced cytokine storm during immune response. Sema3A is a member of the Class 3 semaphorin family of secreted proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200510 [Multi-domain]  Cd Length: 493  Bit Score: 373.18  E-value: 1.35e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  26 NLVPRKTVSSGELATVVRRFSQTGIQD---FLTLTLTEPTGLLYVGAREALFAFSMEALELQGAISWEAPVEKKTECIQK 102
Cdd:cd11249    2 NNVPRLKLSYKEMLESNNLITFNGLANsssYHTFLLDEERGRLYVGAKDHIFSFNLVNIKDFQKIVWPVSPSRRDECKWA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 103 GKNNQTECFNFIRFLQPYNASHLYVCGTYAFQPKCTYVNM------LTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGEL 176
Cdd:cd11249   82 GKDILKECANFIKVLKAYNQTHLYACGTGAFHPVCTYIEVghhpedNIFRLEDSHFENGRGKSPYDPKLLTASLLIDGEL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 177 YSATLNNFLGTEPIILRNMGPHHSMKTE-YLAFWLNEPHFVGSAYVPESVGSftgDDDKVYFFFRERAVESDCYAEQVVA 255
Cdd:cd11249  162 YSGTAADFMGRDFAIFRTLGHHHPIRTEqHDSRWLNDPRFISAHLIPESDNP---EDDKIYFFFRENAIDGEHTGKATHA 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 256 RVARVCKGDMGGARTLQRKWTTFLKARLACSAP---NWQLYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEY 332
Cdd:cd11249  239 RIGQLCKNDFGGHRSLVNKWTTFLKARLICSVPgpnGIDTHFDELQDVFLMNSKDPKNPIVYAVFTTSSNIFKGSAVCMY 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 333 QLEEIQRVFEGPYKEYHEEAQKWDRYTDPVPSPRPGSCINNWHrrHGYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPL 412
Cdd:cd11249  319 SMTDIRRVFLGPYAHRDGPNYQWVPFQGRVPYPRPGTCPSKTF--GGFDSTKDLPDDVITFARSHPAMYNPVFPINNRPI 396
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 413 LVKKGTN--FTHLVADRVTGLDGaTYTVLFIGTGDGWLLKAVSL--GPWVH----LIEELQLFdQEP--MRSLVLSQSKK 482
Cdd:cd11249  397 IIKTDVDyqFTQIVVDRVEAEDG-QYDVMFIGTDMGTVLKVVSIpkETWHDleevLLEEMTVF-REPtaISAMELSTKQQ 474
                        490
                 ....*....|....*...
gi 767918617 483 LLFAGSRSQLVQLPVADC 500
Cdd:cd11249  475 QLYIGSAIGVSQLPLHRC 492
Sema_3F cd11254
The Sema domain, a protein interacting module, of semaphorin 3F (Sema3F); Sema3F is ...
52-500 1.11e-115

The Sema domain, a protein interacting module, of semaphorin 3F (Sema3F); Sema3F is coexpressed with semaphorin3B. Both Sema3B and Sema3F proteins are candidate tumor suppressors that are down-regulated in highly metastatic tumors. Two receptor families, the neuropilins and plexins, have been implicated in mediating the actions of semaphorins 3B and 3F. Sema3F is a member of the class 3 semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200515 [Multi-domain]  Cd Length: 470  Bit Score: 359.52  E-value: 1.11e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  52 DFLTLTLTEPTGLLYVGAREALFAFSMEALELQG-AISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYNASHLYVCGT 130
Cdd:cd11254    9 DYRILLKDEDHDRMYVGSKDYVLSLDLHDINREPlIIHWPASPQRIEECILSGKGSNGECGNFIRLIQPWNRTHLYVCGT 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 131 YAFQPKCTYVNM------LTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNMGPHHSMKTE 204
Cdd:cd11254   89 GAYNPVCAYINRgrraedYMFRLEPDKLESGKGKCPYDPKQDSVSALINGELYAGVYIDFMGTDAAIFRTMGKQPAMRTD 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 205 -YLAFWLNEPHFVGSAYVPESVGSftgDDDKVYFFFRERAVESDcYAEQVVARVARVCKGDMGGARTLQRKWTTFLKARL 283
Cdd:cd11254  169 qYNSRWLNDPAFVHAHLIPDSSEK---NDDKLYFFFREKSLEAP-QSPAVLSRIGRVCLNDDGGHCCLVNKWSTFLKARL 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 284 ACSAPNW---QLYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYTD 360
Cdd:cd11254  245 VCSVPGAdgiETHFDELRDVFIQPTQDTKNPVIYAVFSTSGSVFKGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPYTG 324
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 361 PVPSPRPGSCINNWHRRhGYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTN--FTHLVADRVTGLDGaTYTV 438
Cdd:cd11254  325 KIPYPRPGTCPGGTFTP-SMKSTKDYPDEVINFMRTHPLMYNAVYPVHRRPLVVRTNVNyrFTTIAVDQVDAADG-RYEV 402
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767918617 439 LFIGTGDGWLLKAVSLGPWVHLIEELQLFDQE------PMRSLVLSQSKKLLFAGSRSQLVQLPVADC 500
Cdd:cd11254  403 LFLGTDRGTVQKVIVLPKDDLETEELTLEEVEvfkvpaPIKTMKISSKRQQLYVSSAVGVTHLSLHRC 470
Sema_3D cd11252
The Sema domain, a protein interacting module, of semaphorin 3D (Sema3D); Sema3D is a secreted ...
51-500 1.89e-115

The Sema domain, a protein interacting module, of semaphorin 3D (Sema3D); Sema3D is a secreted semaphorin expressed during the development of the nervous system. In zebrafish, Sema3D is expressed in the ventral tectum. It guides retinal axons along the dorsoventral axis of the tectum and guides the laterality of retinal ganglion cell (RGC) projections. Both Sema3D knockdown or its ubiquitous overexpression induced aberrant ipsilateral projections. Proper balance of Sema3D is needed at the midline for the progression of RGC axons from the chiasm midline into the contralateral optic tract. Sema3D is a member of the class 3 semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200513 [Multi-domain]  Cd Length: 474  Bit Score: 359.22  E-value: 1.89e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  51 QDFLTLTLTEPTGLLYVGAREALFAFSMEALELQ-GAISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYNASHLYVCG 129
Cdd:cd11252    8 LDFQTLLLDEERGRLLLGAKDHIYLLDLVDLNKNpKKIYWPAAKERVELCKLAGKDANTECANFIRVLHPYNRTHVYVCG 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 130 TYAFQPKCTYVNMLT------FTLEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNMGP---HHS 200
Cdd:cd11252   88 TGAFHPTCGYIELGThkedriFLLDTQNLESGRLKCPFDPQQPFASVMTDEYLYAGTASDFLGKDTTFTRSLGPtpdHHY 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 201 MKTEYLA-FWLNEPHFVGSAYVPESvgsFTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQRKWTTFL 279
Cdd:cd11252  168 IRTDISEhYWLNGAKFIGTFPIPDT---YNPDDDKIYFFFREASQDGSTSDKSVLSRVGRVCKNDVGGQRSLINKWTTFL 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 280 KARLACSAPNWQ---LYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWD 356
Cdd:cd11252  245 KARLVCSIPGPDgadTHFDELQDIFLLPTRDERNPVVYGVFTTTSSIFKGSAVCVYSMADIRAVFNGPYAHKESPDHRWV 324
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 357 RYTDPVPSPRPGSCINNWHRRHgYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNF--THLVADRVTGLDGa 434
Cdd:cd11252  325 QYEGRIPYPRPGTCPSKTYDPL-IKSTKDFPDEVISFIKRHPLMYKSVYPLTGGPVFTRINVDYrlTQIVVDHVAAEDG- 402
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767918617 435 TYTVLFIGTGDGWLLKAVSLGP--WVH---LIEELQLFDQ-EPMRSLVLSQSKKLLFAGSRSQLVQLPVADC 500
Cdd:cd11252  403 QYDVMFLGTDIGTVLKVVSITKekWTMeevVLEELQIFKHpSPILNMELSLKQQQLYIGSRDGLVQLSLHRC 474
Sema_3G cd11255
The Sema domain, a protein interacting module, of semaphorin 3G (Sema3G); Semaphorin 3G is ...
49-500 5.51e-111

The Sema domain, a protein interacting module, of semaphorin 3G (Sema3G); Semaphorin 3G is identified as a primarily endothelial cell- expressed class 3 semaphorin that controls endothelial and smooth muscle cell functions in autocrine and paracrine manners, respectively. It is mainly expressed in the lung and kidney, and a little in the brain. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200516 [Multi-domain]  Cd Length: 474  Bit Score: 347.67  E-value: 5.51e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  49 GIQDFLTLTLTEPTGLLYVGAREALFAFSMEALELQG-AISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYNASHLYV 127
Cdd:cd11255    6 GDLHLSAVYLDEYRDRLFLGGKDVLYSLRLDQTHPDAkEIHWPPLPGQREECIRKGKDPETECANFVRVLQPFNRTHLLA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 128 CGTYAFQPKCTYVNM-----LTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNMGPHHSMK 202
Cdd:cd11255   86 CGTGAFQPVCALINVghrgeHVFSLDPTTVESGRGRCPHEPKRPFASTFTGGELYTGLTADFLGRDSVIFRGFGTRSPLR 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 203 TEYLAFWLNEPHFVGSAYVPESVGSftgDDDKVYFFFRERAVESDCYAEQV-VARVARVCKGDMGGARTLQRKWTTFLKA 281
Cdd:cd11255  166 TETDQRLLHEPRFVAAHLIPDNADR---DNDKVYFFFTERATETAEDDDGAiHSRVGRLCANDAGGQRVLVNKWSTFIKA 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 282 RLACSAP---NWQLYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRY 358
Cdd:cd11255  243 RLVCSVPgphGIQTHFDQLEDVFLLRTKDGKSPEIYALFSTISNVFQGFAVCVYSMADIWEVFNGPFAHKDGPDHQWGPY 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 359 TDPVPSPRPGSCINNWHRRHG--YTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGT--NFTHLVADRVTGLDGa 434
Cdd:cd11255  323 EGKVPYPRPGVCPSKITAQPGraFRSTKDYPDEVLQFARAHPLMWRPVYPSHRRPVLVKTGLpyRLTQIVVDRVEAEDG- 401
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767918617 435 TYTVLFIGTGDGWLLKAVSLG------PWVHLIEELQLFD-QEPMRSLVLSQSKKLLFAGSRSQLVQLPVADC 500
Cdd:cd11255  402 YYDVMFIGTDSGSVLKVIVLQkgnsaaGEEVTLEELQVFKvPTPITEMEISVKRQMLYVGSRTGVAQVPLHRC 474
Sema_1A cd11237
The Sema domain, a protein interacting module, of semaphorin 1A (Sema1A); Sema1A is a ...
52-500 1.78e-109

The Sema domain, a protein interacting module, of semaphorin 1A (Sema1A); Sema1A is a transmembrane protein. It has been shown to mediate the defasciculation of motor axon bundles at specific choice points. Sema1A binds to its receptor plexin A (PlexA), which in turn triggers downstream signaling events involving the receptor tyrosine kinase Otk, the evolutionarily conserved flavoprotein monooxygenase molecule interacting with CasL (MICAL), and the A kinase anchoring protein Nervy, leading to repulsive growth-cone response. Sema1A has also been shown to be involved in synaptic formation. It is a member of the semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200498 [Multi-domain]  Cd Length: 446  Bit Score: 342.77  E-value: 1.78e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  52 DFLTLTLTEPTGLLyVGAREALFAFSMEALELQGAISWEAPVEKKTECIQKGKNnQTECFNFIRFLQPYNASHLYVCGTY 131
Cdd:cd11237    5 DHFKLLDQDGNSLL-VGARNAVYNISLSDLTENQRIEWPSSDAHREMCLLKGKS-EDDCQNYIRVLAKKSAGRLLVCGTN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 132 AFQPKCTYVNMLTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNmgphhSMKTE-YLAFWL 210
Cdd:cd11237   83 AYKPLCREYTVKDGGYRVEREFDGQGLCPYDPKHNSTAVYADGQLYSATVADFSGADPLIYRE-----PLRTErYDLKQL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 211 NEPHFVGSAYvpesvgsftgDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQRKWTTFLKARLACSAP-N 289
Cdd:cd11237  158 NAPNFVSSFA----------YGDYVYFFFRETAVEYINCGKAIYSRVARVCKNDKGGPHPFRDRWTSFLKARLNCSVPgE 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 290 WQLYFNQLQAMHTL---QDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEyHEEAQK-WDRY-TDPVPS 364
Cdd:cd11237  228 YPFYFNEIQSTSDIvegGYGGKSAKLIYGVFTTPVNSISGSAVCAFSLQDILEVFDGSFKE-QQDINSnWLPVpSNKVPE 306
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 365 PRPGSCINNwhrrhgytsSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTN--FTHLVAD-RVTGLDGATYTVLFI 441
Cdd:cd11237  307 PRPGQCVND---------SRTLPDVTVNFIKSHPLMDEAVPSFFGRPILVRTSLQyrFTQIAVDpQVKALDGKYYDVLFI 377
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 442 GTGDGWLLKAV--------SLGPWVHlIEELQLFDQ-EPMRSLVLSQSKKL--LFAGSRSQLVQLPVADC 500
Cdd:cd11237  378 GTDDGKVLKAVniasadtvDKVSPVV-IEETQVFPRgVPIRNLLIVRGKDDgrLVVVSDDEIVSIPLHRC 446
Sema_3E cd11253
The Sema domain, a protein interacting module, of semaphorin 3E (Sema3E); Sema3E is a secreted ...
46-500 5.86e-99

The Sema domain, a protein interacting module, of semaphorin 3E (Sema3E); Sema3E is a secreted molecule implicated in axonal path finding and inhibition of developmental and postischemic angiogenesis. It is also highly expressed in metastatic cancer cells. Sema3E signaling, through its high affinity functional receptor Plexin D1, drives cancer cell invasiveness and metastatic spreading. Sema3E is a member of the class 3 semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200514 [Multi-domain]  Cd Length: 471  Bit Score: 316.02  E-value: 5.86e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  46 SQTGIQDFLTLTLTEPTGLLYVGAREALFAFSMEAL-ELQGAISWEAPVEKKTECIQKGKNnQTECFNFIRFLQPYNASH 124
Cdd:cd11253    3 SPFGFLDLHTMLLDEYQERLFVGGRDLLYSLSLERIsANYKEIHWPSTQLQVEDCIMKGRD-KPECANYIRVLHHYNRTH 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 125 LYVCGTYAFQPKCTYVNM------LTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNMGPH 198
Cdd:cd11253   82 LLACGTGAFDPVCAFIRVgrgsedHLFQLESDKFERGRGRCPFDPNSSFISTLIGGELFVGLYSDYWGRDAAIFRTMNHL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 199 HSMKTEYLA-FWLNEPHFVGSAYVPESVGSftgDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQRKWTT 277
Cdd:cd11253  162 AHIRTEHDDeRLLKEPKFVGSYMIPDNEDP---DDNKVYFFFTEKALEAEGGNHAIYTRVGRVCANDQGGQRMLVNKWST 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 278 FLKARLACSAPNWQ---LYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQK 354
Cdd:cd11253  239 FLKTRLICSVPGPNgidTHFDELEDVFLLRTRDNKNPEIFGLFSTTSNIFKGYAICVYHMASIRAAFNGPFAHKEGPEYH 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 355 WDRYTDPVPSPRPGSC---INNWHrrhgYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKK--GTNFTHLVADRVT 429
Cdd:cd11253  319 WSVYEGKVPYPRPGSCaskVNGGH----YGTTKDYPDEALRFARSHPLMYQAVKPVHKRPILVKTdgKYNLKQIAVDRVE 394
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767918617 430 GLDGaTYTVLFIGTGDGWLLKAVSLGPWVH------LIEELQLF-DQEPMRSLVLSQSKKLLFAGSRSQLVQLPVADC 500
Cdd:cd11253  395 AEDG-QYDVLFIGTDNGIVLKVITIYNQETetmeevILEELQVFkVPVPIISMEISSKRQQLYIGSESGVAQIRFHQC 471
Sema_6 cd11242
The Sema domain, a protein interacting module, of class 6 semaphorins (Sema6); Class 6 ...
50-498 1.85e-96

The Sema domain, a protein interacting module, of class 6 semaphorins (Sema6); Class 6 semaphorins (Sema6s) are membrane associated semaphorins. There are 6 subfamilies named 6A to 6D. Sema6s bind to plexin As in a neuropilin independent fashion. Sema6-plexin A signaling plays important roles in lamina-specific axon projections. Interactions between plexin A2, plexin A4, and Sema6A control lamina-restricted projection of hippocampal mossy fibers. Interactions between Sema6C, Sema6D and plexin A1 shape the stereotypic trajectories of sensory axons in the spinal cord. In addition to axon targeting, Sema6D-plexin A1 interactions influence a wide range of other biological processes. During cardiac development, Sema6D attracts or repels endothelial cells in the cardiac tube depending on the expression patterns of specific coreceptors in addition to plexin A1. Furthermore, Sema6D binds a receptor complex comprising of plexin A1, Trem2 (triggering receptor expressed on myeloid cells 2), and DAP12 on dendritic cells and osteoclasts to mediate T-cell-DC interactions and to control bone development, respectively. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200503 [Multi-domain]  Cd Length: 465  Bit Score: 309.06  E-value: 1.85e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  50 IQDFLTLTLTeptglLYVGAREALFAFSMEALELQG-----AISWEAPVEKKTECIQKGKNnQTECFNFIRFLQPYNASH 124
Cdd:cd11242   11 FQRMLRINRT-----LYIAARDHVYTVDLDASHTEEivpskKLTWRSRQADVENCRMKGKH-KDECHNFIKVLVPRNDET 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 125 LYVCGTYAFQPKCTYVNMLTFTLEhGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNMGPHHSMKT- 203
Cdd:cd11242   85 LFVCGTNAFNPVCRNYRIDTLEQD-GEEISGMARCPFDAKQANVALFADGKLYSATVTDFLASDAVIYRSLGDSPTLRTv 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 204 EYLAFWLNEPHFVGSAyvpeSVGSFtgdddkVYFFFRERAVESDCYAEQVVARVARVCKGDMGGA-RTLQRKWTTFLKAR 282
Cdd:cd11242  164 KYDSKWLKEPHFVHAV----EYGDY------VYFFFREIAVEYNTLGKVVFSRVARVCKNDMGGSpRVLEKQWTSFLKAR 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 283 LACSAP-NWQLYFNQLQAMHTLQDTSwHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYT-D 360
Cdd:cd11242  234 LNCSVPgDSHFYFDVLQAVTDVIRIN-GRPVVLGVFTTQYNSIPGSAVCAFDMDDIEKVFEGRFKEQKSPDSAWTPVPeD 312
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 361 PVPSPRPGSCINNwHRRHGYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNF--THLVADRVTGLDGaTYTV 438
Cdd:cd11242  313 RVPKPRPGCCAGS-GSAEKYKTSNDFPDDTLNFIKTHPLMDEAVPSIINRPWFTRTMVRYrlTQIAVDNAAGPYQ-NYTV 390
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767918617 439 LFIGTGDGWLLKAV-----SLGPWVHLIEELQLFD--------QEPMR--SLVLSQSKKLLFAGSRSQLVQLPVA 498
Cdd:cd11242  391 VFLGSEAGTVLKFLarigpSGSNGSVFLEEIDVYNpakcsydgEEDRRiiGLELDRASHALFVAFSGCVIRVPLS 465
Sema_3C cd11251
The Sema domain, a protein interacting module, of semaphorin 3C (Sema3C); Sema3C is a secreted ...
52-500 7.02e-92

The Sema domain, a protein interacting module, of semaphorin 3C (Sema3C); Sema3C is a secreted semaphorin expressed in and adjacent to cardiac neural crest cells, and causes impaired migration of neural crest cells to the developing cardiac outflow tract, resulting in the interruption of the aortic arch and persistent truncus arteriosus. It has been proposed that Sema3C acts as a guidance molecule, regulating migration of neural crest cells that express semaphorin receptors such as plexin A2. Sema3C may also participate in tumor progression. The cleavage of Sema3C induced by ADAMTS1 promotes the migration of breast cancer cells. Sema3C is a member of the class 3 semaphorin family of secreted proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200512 [Multi-domain]  Cd Length: 470  Bit Score: 297.19  E-value: 7.02e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  52 DFLTLTLTEPTGLLYVGAREALFAFSMEALElQGAIS--WEAPVEKKTECIQKGKNNQTECFNFIRFLQPYNASHLYVCG 129
Cdd:cd11251    9 DYRILFMDEDQDRIYVGSKDHILSLNINNIS-QDALSifWPASASKVEECKMAGKDPTHGCGNFVRVIQPYNRTHLYVCG 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 130 TYAFQPKCTYVNM------LTFTLEHgEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNMGPHHSMKT 203
Cdd:cd11251   88 SGAFSPVCVYVNRgrrseeQVFHIDS-KAESGKGRCSFNPNVNTVSVMINEELFSGMYIDFMGTDAAIFRSLTKRNAVRT 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 204 -EYLAFWLNEPHFVGSAYVPESVGSftgDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQRKWTTFLKAR 282
Cdd:cd11251  167 dQHNSKWLSEPIFVDAHLIPDGTDP---NDAKLYFFLKERLTDNSGSTKQIHSMIARVCPNDTGGQRSLVNKWTTFLKAR 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 283 LACSAPN---WQLYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYT 359
Cdd:cd11251  244 LVCSVMDedgTETHFDELEDVFLLETDNPRTTLVYGIFTTSSSVFKGSAVCVYHMSDIQTVFNGPFAHKEGPNHQLIAYQ 323
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 360 DPVPSPRPGSCINNWHRRHgYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTN--FTHLVADRVTGLDGaTYT 437
Cdd:cd11251  324 GRIPYPRPGTCPGGAFTPN-MQSTKEFPDDVVTFIRNHPLMFNPIYPIGRRPLLVRTGTDykYTKIAVDRVNAADG-RYH 401
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767918617 438 VLFIGTGDGWLLKAVSL--GPWVH---LIEELQLF-DQEPMRSLVLSQSKKLLFAGSRSQLVQLPVADC 500
Cdd:cd11251  402 VLFLGTDKGTVQKVVVLptNGSLSgelILEELEVFkNHAPITNMKISSKKQQLYVSSEEGISQVSLHRC 470
Sema_5 cd11241
The Sema domain, a protein interacting module, of semaphorin 5 (Sema5); Class 5 semaphorins ...
45-497 1.07e-82

The Sema domain, a protein interacting module, of semaphorin 5 (Sema5); Class 5 semaphorins are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. There are three subfamilies in class 5 semaphorins, namely 5A, 5B and 5C. Sema5A and Sema5B function as guidance cues for optic and corticofugal nerve development, respectively. Sema5A-induced cell migration requires Met signaling. Sema5C is an early development gene and may play a role in odor-guided behavior. Sema5A is also implicated in cancer. In a screening model for metastasis, the Drosophila Sema5A ortholog, Dsema-5C, has been found to be required in tumorigenicity and metastasis. Sema5A is highly expressed in human pancreatic cancer cells and is associated with tumor growth, invasion and metastasis. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200502 [Multi-domain]  Cd Length: 438  Bit Score: 271.73  E-value: 1.07e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  45 FSQTGIQDFLTLTLTEPTGLLYVGAREALFAFSMEALELQGAISWEAPVEKKTECIQKGKNNQtECFNFIRFLQPYNASh 124
Cdd:cd11241    1 FEIEYVSDFSRLVLDPTHDQLIVGARNYLFRLRLQSLSLLQAVPWNSDEDTKRQCQSKGKSVE-ECQNYVRVLLVVGKN- 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 125 LYVCGTYAFQPKCTYVNMLTFTLEHGEFeDGKGKCPYDPAKGHAGLLV-DGELYSATLNNFLGTEPIILRNMGPHHSMKT 203
Cdd:cd11241   79 LFTCGTYAFSPVCTIRKLSNLTQILDTI-SGVARCPYSPAHNSTALISaSGELYAGTVYDFSGRDPAIYRSLGGKPPLRT 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 204 -EYLAFWLNEPHFVGSayvpESVGSFTgdddkvYFFFRERAVE-SDCyAEQVVARVARVCKGDMGGARTLQRKWTTFLKA 281
Cdd:cd11241  158 aQYNSKWLNEPNFVGS----YEIGNHT------YFFFRENAVEhQDC-GKTVYSRIARVCKNDIGGRFLLEDTWTTFMKA 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 282 RLACSAP-NWQLYFNQLQAMHTLQDTSwhntTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKeYHEEAQKWDRytd 360
Cdd:cd11241  227 RLNCSLPgEFPFYYNEIQGTFYLPETD----LIYAVFTTNVNGIAGSAICAFNLSAINQAFNGPFK-YQENNGSAWL--- 298
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 361 PVPSPRPGSCINNWHRRHGYTSSLE--LPDNilnfvKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVADRVTGLDGATYTV 438
Cdd:cd11241  299 PTPNPHPNFQCTTSIDRGQPANTTErdLQDA-----QKYQLMAEVVQPVTKIPLVTMDDVRFSKLAVDVVQGRGTQLVHI 373
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767918617 439 LFIGTGDGWLLKAVSLGPWVHL--IEELQLF---DQEPMRSLVLSQSKKLLFAGSRSQLVQLPV 497
Cdd:cd11241  374 FYVGTDYGTILKMYQPHRSQKSctLEEIKILpamKGEPITSLQFLKSEKSLFVGLETGVLRIPL 437
Sema_5B cd11264
The Sema domain, a protein interacting module, of semaphorin 5B (Sema5B); Sema5B is expressed ...
45-498 1.12e-82

The Sema domain, a protein interacting module, of semaphorin 5B (Sema5B); Sema5B is expressed in regions of the basal telencephalon in rat. Sema5B is an inhibitory cue for corticofugal axons and acts as a source of repulsion for the appropriate guidance of cortical axons away from structures such as the ventricular zone as they navigate toward and within subcortical regions. In addition to its role as a guidance cue, Sema5B regulates the development and maintenance of synapse size and number in hippocampal neurons. In addition, the sema domain of Sema5B can be cleaved of the whole protein and exerts its function in regulation of synapse morphology. Sema5B belongs to the class 5 semaphorin family of proteins, which are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200525 [Multi-domain]  Cd Length: 437  Bit Score: 271.86  E-value: 1.12e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  45 FSQTGIQDFLTLTLTEPTGLLYVGAREALFAFSMEALELQGAISWEAPVEKKTECIQKGKNnQTECFNFIRFLQpYNASH 124
Cdd:cd11264    1 FTYPGVRDFSQLALDLNRNQLIVGARNYLFRLSLHNVSLIQATEWGSDEDTRRSCQSKGKT-EEECQNYVRVLI-VYGKK 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 125 LYVCGTYAFQPKCT--YVNMLTFTLEHgefEDGKGKCPYDPAKGHAGLLVD-GELYSATLNNFLGTEPIILRNMGPHHSM 201
Cdd:cd11264   79 VFTCGTNAFSPVCTsrQVGNLSKVIER---INGVARCPYDPRHNSTAVITSrGELYAATVIDFSGRDPAIYRSLGSVPPL 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 202 KT-EYLAFWLNEPHFVgSAYvpeSVGSFTgdddkvYFFFRERAVESDCyAEQVVARVARVCKGDMGGARTLQRKWTTFLK 280
Cdd:cd11264  156 RTaQYNSKWLNEPNFI-AAY---DIGLFT------YFFFRENAVEHDC-GKTVYSRVARVCKNDIGGRFLLEDTWTTFMK 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 281 ARLACSAP-NWQLYFNQLQAMHTL--QDtswhntTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDR 357
Cdd:cd11264  225 ARLNCSRPgEIPFYYNELQSTFYLpeQD------LIYGVFTTNVNSIAASAVCAFNLSAITQAFNGPFRYQENPRSAWLP 298
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 358 YTDPVPSPRPGSCINNwhrrhgyTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVADRVTGLDgATYT 437
Cdd:cd11264  299 TANPIPNFQCGTLSDD-------SPNENLTERSLQDAQRLFLMNDVVQPVTVDPLVTQDSVRFSKLVVDIVQGKD-TLYH 370
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767918617 438 VLFIGTGDGWLLKAVSL-GPWVH--LIEELQLF---DQEPMRSLVLSQSKKLLFAGSRSQLVQLPVA 498
Cdd:cd11264  371 VMYIGTEYGTILKALSTtNRSLRscYLEEMQILppgQREPIRSLQILHSDRSLFVGLNNGVLKIPLE 437
Sema_6D cd11269
The Sema domain, a protein interacting module, of semaphorin 6D (Sema6D); Sema6D is expressed ...
52-498 1.15e-82

The Sema domain, a protein interacting module, of semaphorin 6D (Sema6D); Sema6D is expressed predominantly in the nervous system during embryogenesis and it uses Plexin-A1 as a receptor. It displays repellent activity for dorsal root ganglion axons. Sema6D also acts as a regulator of late phase primary immune responses. In addition, Sema6D is overexpressed in gastric carcinoma, indicating that it may have an important role in the occurrence and development of the cancer. Sema6D is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200530 [Multi-domain]  Cd Length: 465  Bit Score: 272.67  E-value: 1.15e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  52 DFLTLTLTEPTglLYVGAREALFAFSMEAL---ELQGA--ISWEAPVEKKTECIQKGKNnQTECFNFIRFLQPYNASHLY 126
Cdd:cd11269   10 DFQLMLKIRDT--LYIAGRDQVYTVNLNEVpktEVTPSrkLTWRSRQQDRENCAMKGKH-KDECHNFIKVFVPRNDEMVF 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 127 VCGTYAFQPKCTYVNMLTFTLEhGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNMGPHHSMKT-EY 205
Cdd:cd11269   87 VCGTNAFNPMCRYYRLSTLEYD-GEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTiKY 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 206 LAFWLNEPHFVGSAyvpeSVGSFtgdddkVYFFFRERAVESDCYAEQVVARVARVCKGDMGGA-RTLQRKWTTFLKARLA 284
Cdd:cd11269  166 DSKWIKEPHFLHAI----EYGNY------VYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSqRVLEKHWTSFLKARLN 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 285 CSAPNWQ-LYFNQLQAMHTLQDTSwHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRY-TDPV 362
Cdd:cd11269  236 CSVPGDSfFYFDVLQSITDIIEIN-GIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVpEDKV 314
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 363 PSPRPGSCInnwhrRHG----YTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNF--THLVADRVTGlDGATY 436
Cdd:cd11269  315 PKPRPGCCA-----KHGlaeaYKTSIDFPDETLSFIKSHPLMDSAVPSIIEEPWFTKTRVRYrlTAIAVDHAAG-PHQNY 388
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767918617 437 TVLFIGTGDGWLLKAV------SLGPWVhLIEELQLFDQ-------EPMR---SLVLSQSKKLLFAGSRSQLVQLPVA 498
Cdd:cd11269  389 TVIFVGSEAGVVLKILaktspfSLNDSV-LLEEIEAYNHakcsaenEEDRrviSLQLDRDHHALFVAFSSCVVRIPLS 465
Sema_6B cd11267
The Sema domain, a protein interacting module, of semaphorin 6B (Sema6B); Sema6B functions as ...
50-498 1.48e-82

The Sema domain, a protein interacting module, of semaphorin 6B (Sema6B); Sema6B functions as repellents for axon growth; this repulsive activity is mediated by its receptor Plexin A4. Sema6B is expressed in CA3, and repels mossy fibers in a Plexin A4 dependent manner. In human, it was shown that peroxisome proliferator-activated receptors (PPARs) and 9-cis-retinoic acid receptor (RXR) regulate human semaphorin 6B (Sema6B) gene expression. Sema6B is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200528 [Multi-domain]  Cd Length: 466  Bit Score: 272.48  E-value: 1.48e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  50 IQDFLTLTLTeptglLYVGAREALFAFSMEA-----LELQGAISWEAPVEKKTECIQKGKNnQTECFNFIRFLQPYNASH 124
Cdd:cd11267   11 IQRVLRVNRT-----LYIGDRDNLYRVELDPtagteMRYHKKLTWRSNKNDINVCRMKGKH-EGECRNFIKVLLLRDYGT 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 125 LYVCGTYAFQPKCTyvNMLTFTLEH-GEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNMGPHHSMKT 203
Cdd:cd11267   85 LFVCGTNAFNPVCA--NYSIDTLEPvGDNISGMARCPYDPKHANVALFADGMLFTATVTDFLAIDAVIYRSLGDSPALRT 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 204 -EYLAFWLNEPHFVGSAYVPEsvgsftgdddKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGA-RTLQRKWTTFLKA 281
Cdd:cd11267  163 vKHDSKWFKEPYFVHAVEWGS----------HVYFFFREIAMEFNYLEKVVVSRVARVCKNDMGGSqRVLEKQWTSFLKA 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 282 RLACSAP-NWQLYFNQLQAMHTLQDTSWHNTTfFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYTD 360
Cdd:cd11267  233 RLNCSVPgDSHFYFNVLQAVSDILNLGGRPVV-LAVFSTPTNSIPGSAVCAFDMTQVAAVFEGRFREQKSPESIWTPVPE 311
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 361 P-VPSPRPGSCINNWHRrhgYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNF--THLVADRVTGLDGaTYT 437
Cdd:cd11267  312 ElVPRPRPGCCAAPGMR---YNSSSTLPDEVLNFVKTHPLMDEAVPSLGHAPWIVRTMTRYqlTHMVVDTEAGPHG-NHT 387
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 438 VLFIGTGDGWLLK--------AVSLGPWVHLIEELQLF-----------DQEPMRSLVLSQSKKLLFAGSRSqLVQLPVA 498
Cdd:cd11267  388 VVFLGSTRGTVLKfliipnasSSEISNQSVFLEELETYnpercgwdspqAQKLLSLELDKGSGGLLLAFPSC-VVRVPVA 466
Sema_5A cd11263
The Sema domain, a protein interacting module, of semaphorin 5A (Sema5A); Originally, mouse ...
45-497 6.98e-81

The Sema domain, a protein interacting module, of semaphorin 5A (Sema5A); Originally, mouse Sema5A was identified as a protein that induces inhibitory responses during optic nerve development. Recent studies show that Sema5A controls innate immunity in mice. It also has been identified as a candidate gene for causing idiopathic autism in humans. Plexin B3 functions as a binding partner and receptor for Sema5A. Furthermore, Sema5A is also implicated in cancer. The role of the Drosophila Sema5A ortholog, Dsema-5C, in tumorigenicity and metastasis has been reported. Sema5A is highly expressed in human pancreatic cancer cells and is associated with tumor growth, invasion and metastasis. Sema5A belongs to class 5 semaphorin family of proteins, which are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200524 [Multi-domain]  Cd Length: 436  Bit Score: 266.90  E-value: 6.98e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  45 FSQTGIQDFLTLTLTEPTGLLYVGAREALFAFSMEALELQGAISWEAPVEKKTECIQKGKNNQtECFNFIRFLQpYNASH 124
Cdd:cd11263    1 FRAENAVDFSQLTFDPGQKELIVGARNYLFRLQLEDLSLIQAVEWECDEATKKACYSKGKSKE-ECQNYIRVLL-VGGDR 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 125 LYVCGTYAFQPKCTYVNMLTFTLEHGEFEdGKGKCPYDPAKGHAGLLV-DGELYSATLNNFLGTEPIILRNMGPHHSMKT 203
Cdd:cd11263   79 LFTCGTNAFTPICTNRTLNNLTEIHDQIS-GMARCPYSPQHNSTALLTsSGELYAATAMDFPGRDPAIYRSLGILPPLRT 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 204 -EYLAFWLNEPHFVgSAYvpeSVGSFTgdddkvYFFFRERAVESDCyAEQVVARVARVCKGDMGGARTLQRKWTTFLKAR 282
Cdd:cd11263  158 aQYNSKWLNEPNFV-SSY---DIGNFT------YFFFRENAVEHDC-GKTVFSRAARVCKNDIGGRFLLEDTWTTFMKAR 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 283 LACSAP-NWQLYFNQLQAMHTLQDTSwhntTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYTDP 361
Cdd:cd11263  227 LNCSRPgEIPFYYNELQSTFFLPELD----LIYGIFTTNVNSIAASAVCVFNLSAISQAFNGPFKYQENSRSAWLPYPNP 302
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 362 VPSPRPGSCINNWHrrhgytssLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVADRVTGLDgATYTVLFI 441
Cdd:cd11263  303 NPNFQCGTMDQGLY--------VNLTERNLQDAQKFILMHEVVQPVTPVPYFMEDNSRFSHVAVDVVQGKD-MLFHIIYL 373
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767918617 442 GTGDGWLLKAvsLGPWVH-----LIEELQLF---DQEPMRSLVLSQSKKLLFAGSRSQLVQLPV 497
Cdd:cd11263  374 ATDYGTIKKV--LAPLNQsssscLLEEIELFpkrQREPIRSLQILHSQSVLFVGLQEHVIKIPL 435
Sema_2A cd11238
The Sema domain, a protein interacting module, of semaphorin 2A (Sema2A); Sema2A, a secreted ...
53-498 2.26e-79

The Sema domain, a protein interacting module, of semaphorin 2A (Sema2A); Sema2A, a secreted semaphorin, signals through its receptor plexin B (PlexB) to regulate central and peripheral axon pathfinding. In the Drosophila embryo, Sema2A secreted by oenocytes interacts with PlexB to guide sensory axons. Sema2A is a member of the semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200499 [Multi-domain]  Cd Length: 452  Bit Score: 263.52  E-value: 2.26e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  53 FLTLTLTEPTGLLYVGAREALFAFSMEALELQGAI----SWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYN-ASHLYV 127
Cdd:cd11238    3 YRTLLLDEKRNALYVGAMDRVFRLNLYNINDTGNNcardELTLSPSDVSECVSKGKDEEYECRNHVRVIQPMGdGQTLYV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 128 CGTYAFQPK--CTYVNMLTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDG-------ELYSATLNNFLGTEPIILR----- 193
Cdd:cd11238   83 CSTNAMNPKdrVLDANLLHLPEYVPGPGNGIGKCPYDPDDNSTAVWVEWgnpgdlpALYSGTRTEFTKANTVIYRpplyn 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 194 -NMGPHH-SMKT-EYLAFWLNEPHFVGSAyvpeSVGSFtgdddkVYFFFRERAVE-SDCyaEQVV-ARVARVCKGDMGGA 268
Cdd:cd11238  163 nTKGRHEsFMRTlKYDSKWLDEPNFVGSF----DIGDY------VYFFFRETAVEyINC--GKVVySRVARVCKKDTGGK 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 269 RTLQRKWTTFLKARLACSAP-NWQLYFNQLQAMHTLQDTSwhNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVF-EGPYK 346
Cdd:cd11238  231 NVLRQNWTTFLKARLNCSISgEFPFYFNEIQSVYKVPGRD--DTLFYATFTTSENGFTGSAVCVFTLSDINAAFdTGKFK 308
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 347 EYHEEAQKW-DRYTDPVPSPRPGSCINNwhrrhgytsSLELPDNILNFVKKHPLMEEQVGPrwSRPLLVKKGTNFTHLVA 425
Cdd:cd11238  309 EQASSSSAWlPVLSSEVPEPRPGTCVND---------SATLSDTVLHFARTHPLMDDAVSH--GPPLLYLRDVVFTHLVV 377
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 426 DRVTGlDGATYTVLFIGTGDGWLLKAVSlgpWVH-------LIEELQLFDQEPMRSLVLSQSKKlLFAGSRSQLVQLPVA 498
Cdd:cd11238  378 DKLRI-DDQEYVVFYAGSNDGKVYKIVH---WKDagesksnLLDVFELTPGEPIRAMELLPGEF-LYVASDHRVSQIDLA 452
Sema_6A cd11266
The Sema domain, a protein interacting module, of semaphorins 6A (Sema6A); In the cerebellum, ...
43-450 9.15e-78

The Sema domain, a protein interacting module, of semaphorins 6A (Sema6A); In the cerebellum, Sema6A-plexin A2 signaling modulates granule cell migration by controlling centrosome positioning. Besides plexin A2, plexin A4 is also found to be a receptor of Sema6A. Interactions between plexin A2, plexin A4, and Sema6A control lamina-restricted projection of hippocampal mossy fibers. It is required for the clustering of boundary cap cells at the PNS/CNS interface and thus, prevents motoneurons from streaming out of the ventral spinal cord. At the dorsal root entry site, it organizes the segregation of dorsal roots. Sema6A may also be involved in axonal pathfinding processes in the periinfarct and homotopic contralateral cortex. Sema6A is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200527 [Multi-domain]  Cd Length: 466  Bit Score: 259.58  E-value: 9.15e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  43 RRFSQTGIQDFLTLTLTEPTglLYVGAREALFAFSM-----EALELQGAISWEAPVEKKTECIQKGKNnQTECFNFIRFL 117
Cdd:cd11266    1 RNTTQRHRLDIQMIMIMNRT--LYIAARDHIYTVDIdtshtEEIYFSKKLTWKSRQADVDTCRMKGKH-KDECHNFIKVL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 118 QPYNASHLYVCGTYAFQPKCTYVNMLTFTLEHGEFEdGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNMGP 197
Cdd:cd11266   78 LKRNDDTLFVCGTNAFNPSCRNYKMDTLEFFGDEFS-GMARCPYDAKHANVALFADGKLYSATVTDFLAIDAVIYRSLGD 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 198 HHSMKT-EYLAFWLNEPHFVGSAyvpeSVGSFtgdddkVYFFFRERAVESDCYAEQVVARVARVCKGDMGGA-RTLQRKW 275
Cdd:cd11266  157 SPTLRTvKHDSKWLKEPYFVQAV----DYGDY------IYFFFREIAVEYNSMGKVVFPRVAQVCKNDMGGSqRVLEKQW 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 276 TTFLKARLACSAP-NWQLYFNQLQAMHTLQDTSWHNTTfFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQK 354
Cdd:cd11266  227 TSFLKARLNCSVPgDSHFYFNILQAVTDVIHINGRDVV-LATFSTPYNSIPGSAVCAYDMLDIASVFTGRFKEQKSPDST 305
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 355 WDRYTDP-VPSPRPGSCINNwHRRHGYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNF--THLVADRVTGl 431
Cdd:cd11266  306 WTPVPDErVPKPRPGCCAGS-SSLEKYATSNEFPDDTLNFIKTHPLMDEAVPSIINRPWFLRTMVRYrlTKIAVDNAAG- 383
                        410
                 ....*....|....*....
gi 767918617 432 DGATYTVLFIGTGDGWLLK 450
Cdd:cd11266  384 PYQNHTVVFLGSEKGIILK 402
Sema_6C cd11268
The Sema domain, a protein interacting module, of semaphorin 6C (Sema6C, also called ...
51-467 2.40e-75

The Sema domain, a protein interacting module, of semaphorin 6C (Sema6C, also called semaphorin Y); Sema6C is highly expressed in adult brain and skeletal muscle and it shows growth cone collapsing activity. It may play a role in the maintenance and remodelling of neuronal connections. In adult skeletal muscle, this role includes prevention of motor neuron sprouting and uncontrolled motor neuron growth. The expression of Sema6C in adult skeletal muscle is down-regulated following denervation. Sema6C is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200529 [Multi-domain]  Cd Length: 465  Bit Score: 253.08  E-value: 2.40e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  51 QDFLTLTLTeptglLYVGAREALFAFSMEALElQGA-------ISWEApvEKKTECIQKGKNNQtECFNFIRFLQPYNAS 123
Cdd:cd11268   12 QRFLTLNRT-----LLVAARDHVFSFDLQAEE-EGEglvpnkyLTWRS--QDVENCAVRGKLTD-ECYNYIRVLVPWDSQ 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 124 HLYVCGTYAFQPKCTYVNMLTFTLEhGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNMGPHHSMKT 203
Cdd:cd11268   83 TLLACGTNSFSPVCRSYGITSLQQE-GEELSGQARCPFDATQSNVAIFAEGSLYSATAADFQASDAVVYRSLGPQPPLRS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 204 -EYLAFWLNEPHFVGSayvpesvgsfTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGA-RTLQRKWTTFLKA 281
Cdd:cd11268  162 aKYDSKWLREPHFVQA----------LEHGDHVYFFFREVSVEDARLGRVQFSRVARVCKRDMGGSpRALDRHWTSFLKL 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 282 RLACSAP-NWQLYFNQLQAMhtLQDTSWH-NTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYT 359
Cdd:cd11268  232 RLNCSVPgDSTFYFDVLQAL--TGPVNLHgRSALFGVFTTQTNSIPGSAVCAFYLDEIERGFEGKFKEQRSLDGAWTPVS 309
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 360 -DPVPSPRPGSCINNWHRRHgYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVAdrVTGLDG--ATY 436
Cdd:cd11268  310 eDRVPSPRPGSCAGVGGAAL-FSSSRDLPDDVLTFIKAHPLLDPAVPPVTHQPLLTLTSRALLTQVA--VDGMAGphSNI 386
                        410       420       430
                 ....*....|....*....|....*....|....*.
gi 767918617 437 TVLFIGTGDGWLLKAV-----SLGPWVHLIEELQLF 467
Cdd:cd11268  387 TVMFLGSNDGTVLKVLppggrSGGPEPILLEEIDAY 422
Sema_5C cd11265
The Sema domain, a protein interacting module, of semaphorin 5C (sema5C); In Drosophila, ...
67-496 4.01e-75

The Sema domain, a protein interacting module, of semaphorin 5C (sema5C); In Drosophila, Sema5C was identified as an early development gene, which is expressed in stage 2 embryos with a striped pattern emerging at later stages. Sema5c may play a role in odor-guided behavior and in tumorigenesis. Sema5C belongs to class 5 semaphorin family of proteins, which are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200526 [Multi-domain]  Cd Length: 433  Bit Score: 251.24  E-value: 4.01e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  67 VGAREALFAFSMEALELQGAISWEAPVEKKTECIQKGKNNQtECFNFIRFLQPYnASHLYVCGTYAFQPKCTYVNMLTFT 146
Cdd:cd11265   23 VGARDNLYRLSLDGLELLERASWPAAESKVALCQNKGQSEE-DCHNYVKVLLSY-GKQLFACGTNAFSPRCSWREMENLT 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 147 LEHGEfEDGKGKCPYDPAKGHAGLLV-DGELYSATLNNFLGTEPIILRNMGP--HHSMKT-EYLAFWLNEPHFVGSAyvp 222
Cdd:cd11265  101 SVTEW-DSGVAKCPYSPHANITALLSsSGQLFVGSPTDFSGSDSAIYRTLGTsnKSFLRTkQYNSKWLNEPQFVGSF--- 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 223 ESvgsftgdDDKVYFFFRERAVE-SDCyAEQVVARVARVCKGDMGGARTLQR-KWTTFLKARLACSAP-NWQLYFNQLQA 299
Cdd:cd11265  177 ET-------GNFVYFLFRESAVEyMNC-GKVIYSRIARVCKNDVGGGTMLLKdNWTTFLKARLNCSLPgEYPFYFDEIQG 248
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 300 MHTLQDTSwhntTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYtdpvpsprpgsciNNWHRRHG 379
Cdd:cd11265  249 MTYLPDEG----ILYATFTTPENSIAGSAVCAFNLSSINAAFDGPFKHQESSGAAWERV-------------NVNHRDHF 311
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 380 YTSSLELPDNILNfVKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVADRVTGLDGATYTVLFIGTGDGwLLKAVSLGP--- 456
Cdd:cd11265  312 NQCSSSSSSHLLE-SSRYQLMDEAVQPITLEPLHHAKLERFSHIAVDVIPTKIHQSVHVLYVATTGG-LIKKISVLPrtq 389
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 767918617 457 ---WVHLIEELQLFDQEPMRSLVLSQSKKlLFAGSRSQLVQLP 496
Cdd:cd11265  390 etcLVEIWQPLPTPDSPIKTMQYLKVTDS-LYVGTELALMRIP 431
Sema_6E cd11270
The Sema domain, a protein interacting module, semaphorin 6E (sema6E); Sema6E is expressed ...
65-498 2.52e-74

The Sema domain, a protein interacting module, semaphorin 6E (sema6E); Sema6E is expressed predominantly in the nervous system during embryogenesis. It binds Plexin A1 and might utilize it as a receptor to repel axons of specific types during development. Sema6E acts as a repellent to dorsal root ganglion axons as well as sympathetic axons. Sema6E is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200531 [Multi-domain]  Cd Length: 462  Bit Score: 250.03  E-value: 2.52e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  65 LYVGAREALFAFSM----EALELQGAISWEApvEKKTECIQKGKNnQTECFNFIRFLQPYNASHLYVCGTYAFQPKCTYV 140
Cdd:cd11270   21 VYIAARDHVFAINLsaslERIVPQQKLTWKT--KDVEKCTVRGKN-SDECYNYIKVLVPRNDETLFACGTNAFNPTCRNY 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 141 NMLTFTLEHGEFeDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNMGPHHSM--KTEYLAFWLNEPHFVGS 218
Cdd:cd11270   98 KMSSLEQDGEEV-IGQARCPFESRQSNVGLFAGGDFYSATMTDFLASDAVIYRSLGESSPVlrTVKYDSKWLREPHFLHA 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 219 AyvpeSVGSFtgdddkVYFFFRERAVESDCYAEQVVARVARVCKGDMGGA-RTLQRKWTTFLKARLACSAP-NWQLYFNQ 296
Cdd:cd11270  177 I----EYGNY------VYFFLSEIAVEYTTLGKVVFSRVARVCKNDNGGSpRVLERYWTSFLKARLNCSVPgDSFFYFDV 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 297 LQAMHTLQDTSwHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRY-TDPVPSPRPGSCInNWH 375
Cdd:cd11270  247 LQSLTNVMQIN-HRPAVLGVFTTQANSITGSAVCAFYMDDIEKVFNGKFKEQRNSESAWTPVpDEAVPKPRPGSCA-GDG 324
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 376 RRHGYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNF--THLVADRVTGLDGaTYTVLFIGTGDGWLLKAVS 453
Cdd:cd11270  325 PAAGYKSSTNFPDETLTFIKSYPLMDEAVPSVNNRPCFTRTTSRFklTQIAVDTAAGPYK-NYTVVFLGSENGHVLKVLA 403
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767918617 454 LGPWVHLIEELQLFD------------QEPMR--SLVLSQSKKLLFAGSRSQLVQLPVA 498
Cdd:cd11270  404 SMHPNSSYSTQVLEDidvynpnkcnvrGEDRRilGLELDKDHHALFVAFTGCVIRVPLS 462
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
297-479 8.48e-70

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 227.92  E-value: 8.48e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  297 LQAMHTLQ--DTSWHNTTFFGVFQAQWGD-MYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYTDPVPSPRPGSCINN 373
Cdd:pfam01403   1 LQDVFVLKpgAGDALDTVLYGVFTTQWSNsIGGSAVCAFSLSDINAVFEGPFKEQEKSDSKWLPYTGKVPYPRPGTCIND 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  374 WHRrhgytssLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVADRVTGLDGaTYTVLFIGTGDGWLLKAVS 453
Cdd:pfam01403  81 PLR-------LDLPDSVLNFVKDHPLMDEAVQPVGGRPLLVRTGVRLTSIAVDRVQALDG-NYTVLFLGTDDGRLHKVVL 152
                         170       180
                  ....*....|....*....|....*...
gi 767918617  454 LGP-WVHLIEELQLFDQ-EPMRSLVLSQ 479
Cdd:pfam01403 153 VGSeESHIIEEIQVFPEpQPVLNLLLSS 180
Sema_7A cd11243
The Sema domain, a protein interacting module, of semaphorin 7A (Sema7A, also called CD108); ...
61-498 1.42e-69

The Sema domain, a protein interacting module, of semaphorin 7A (Sema7A, also called CD108); Sema7A plays regulatory roles in both immune and nervous systems. Unlike other semaphorins, which act as repulsive guidance cues, Sema7A enhances central and peripheral axon growth and is required for proper axon tract formation during embryonic development. Sema7A also plays a critical role in the negative regulation of T cell activation and function. Sema7A is a membrane-anchored member of the semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200504 [Multi-domain]  Cd Length: 414  Bit Score: 235.90  E-value: 1.42e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  61 PTGLLYVGAREALFAFSMEAlelqGAISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYNAShLYVCGTYAFQPKCtyv 140
Cdd:cd11243   12 GSSSVYVGGQGALYLLDFTG----SAVIVKKIPDEKTEKDCKKRATLDDCENYITLIKKLDYR-LLVCGTNAGSPKC--- 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 141 nmltFTLEHGEFE---DGKGKCPYDPAKGHAGLLVDGELYSAtlNNFLGTEPIILRNMGPHHSMKTEylAFWLNEPHFVG 217
Cdd:cd11243   84 ----WFLVNQTLVtlsADRGVAPFLPDENSLVLIEGNNVYST--ISGKKGNIPRFRRYGGKKELYTS--DTVMQKPQFVK 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 218 SAYVPESvgsfTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQ-RKWTTFLKARLACSAPNWQLYFNQ 296
Cdd:cd11243  156 ATLLPED----EQYQDKIYYFFREDNEDKGPEAEPNISRVARLCKEDQGGTSSLStSKWSTFLKARLVCGDPATPMNFNR 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 297 LQAMHTLQDTSWHNTTFFGVFQAQWGDmylSAICEYQLEEIQRVFegpykeyheEAQKWDRYTDPVPSPRPGSCInnwhr 376
Cdd:cd11243  232 LQDVFLLPKEEWREAVVYGVFSNTWGS---SAVCSYSLGDIDKVF---------RTSSLKGYSGSLPNPRPGTCV----- 294
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 377 rhgyTSSLELPDNILNFVKKHPLMEEQVGPRWSRPL-LVKKGTNFTHLVADRVTGLDGATYTVLFIGTGDGWLLKAVSLG 455
Cdd:cd11243  295 ----PPEQTHPSETFSFADEHPELDDRIEPDEPRKLpVFQNKDHYQKVVVDEVRASDGVSYDVLYLATDKGKIHKVVESK 370
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 767918617 456 PWVHLIEELQLF-DQEPMRSLVLSQSKKLLFAGSRSQLVQLPVA 498
Cdd:cd11243  371 GQTHNIMEIQPFkEQEPIQSMILDAERSHLYVGTKAEVTRLPLD 414
Sema cd09295
The Sema domain, a protein interacting module, of semaphorins and plexins; Both semaphorins ...
52-498 1.64e-66

The Sema domain, a protein interacting module, of semaphorins and plexins; Both semaphorins and plexins have a Sema domain on their N-termini. Plexins function as receptors for the semaphorins. Evolutionarily, plexins may be the ancestor of semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems, and cancer. Semaphorins can be divided into 7 classes. Vertebrates have members in classes 3-7, whereas classes 1 and 2 are known only in invertebrates. Class 2 and 3 semaphorins are secreted; classes 1 and 4 through 6 are transmembrane proteins; and class 7 is membrane associated via glycosylphosphatidylinositol (GPI) linkage. Plexins are a large family of transmembrane proteins, which are divided into four types (A-D) according to sequence similarity. In vertebrates, type A plexins serve as co-receptors for neuropilins to mediate the signalling of class 3 semaphorins. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B plexins. This family also includes the MET and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves to recognize and bind receptors.


Pssm-ID: 200495 [Multi-domain]  Cd Length: 392  Bit Score: 226.70  E-value: 1.64e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  52 DFLTLTLTEPTGLLYVGAREALFAF-----SMEALELQGAISWEaPVEKKTECIQKGKNNQTECFNFIRFLQPYNAS-HL 125
Cdd:cd09295    1 DDDKILVSFRKDTIYVGAIARIYKVdgggtRLLLSCISPELNFG-FNEDQKAFCPLRRGKWTECINYIKVLQQKGDLdIL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 126 YVCGTYAFQPKC-TYVNMLTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFL-GTEPIILRNMGPHHSMKT 203
Cdd:cd09295   80 AVCGSNAAQPSCgSYRLDVLVELGKVRWPSGRPRCPIDNKHSNMGVNVDSKLYSATDHDFKdGDRPALSRRSSNVHYLRI 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 204 EYL-AFWLNEPHFV-GSAYvpesvgsfTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQRKWTTFLKA 281
Cdd:cd09295  160 VVDsSTGLDEITFVyAFVS--------GDDDDEVYFFFRQEPVEYLKKGMVYVPRIARVCKLDVGGCHRLKKKLTSFLKA 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 282 RLACSAPNWQLYFNQLQAMHTLQDTSWHNtTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEgpykeyheeaqkwdrytDP 361
Cdd:cd09295  232 DLNCSRPQSGFAFNLLQDATGDTKNLIQD-VKFAIFSSCLNKSVESAVCAYLFTDINNVFD-----------------DP 293
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 362 VPSprpgscINNwhrrhgytsslelpdnilnfvkkhplmeeqvgprwsRPLLVKKGT--NFTHLVADRvTGLDGATYTVL 439
Cdd:cd09295  294 VEA------INN------------------------------------RPLYAHQNQrsRLTSIAVDA-TKQKSVGYQVV 330
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767918617 440 FIGTGDGWLLKAVSLGPWV--HLIEELQLF-DQEPMRSLVLSQSKKLLFAGSRSQLVQLPVA 498
Cdd:cd09295  331 FLGLKLGSLGKALAFFFLYkgHIIEEWKVFkDSSRITNLDLSRPPLYLYVGSESGVLGVPVQ 392
Ig_Sema4B_like cd05872
Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B; The members here are ...
563-647 5.31e-20

Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B; The members here are composed of the immunoglobulin (Ig)-like domain of Sema4B and similar proteins. Sema4B is a Class IV semaphorin. Semaphorins are classified based on structural features additional to the Sema domain. Sema4B has extracellular Sema and Ig domains, a transmembrane domain, and a short cytoplasmic domain. Sema4B has been shown to preferentially regulate the development of the postsynaptic specialization at the glutamatergic synapses. This cytoplasmic domain includes a PDZ-binding motif upon which the synaptic localization of Sem4B is dependent. Sema4B is a ligand of CLCP1. CLCP1 was identified in an expression profiling analysis, which compared a highly metastic lung cancer subline with its low metastic parental line. Sema4B was shown to promote CLCP1 endocytosis and their interaction is a potential target for therapeutic intervention of metastasis.


Pssm-ID: 409456  Cd Length: 86  Bit Score: 85.18  E-value: 5.31e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 563 KNITVVAGTDLVLPCHLSSNLAHARWTFGGRDLPAEQPGSFLydaRLQALVVMAAQPRHAGAYHCFSEEQGARLAAEGYL 642
Cdd:cd05872    4 KFRTVVAGADVVLPCQLRSNLASPVWLFNGTPLNAQFSYLRL---GTDGLLILVTSPEHSGTYRCYSEEEGFQQLVASYS 80

                 ....*
gi 767918617 643 VAVVA 647
Cdd:cd05872   81 LNVVE 85
Sema cd09295
The Sema domain, a protein interacting module, of semaphorins and plexins; Both semaphorins ...
231-520 1.16e-18

The Sema domain, a protein interacting module, of semaphorins and plexins; Both semaphorins and plexins have a Sema domain on their N-termini. Plexins function as receptors for the semaphorins. Evolutionarily, plexins may be the ancestor of semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems, and cancer. Semaphorins can be divided into 7 classes. Vertebrates have members in classes 3-7, whereas classes 1 and 2 are known only in invertebrates. Class 2 and 3 semaphorins are secreted; classes 1 and 4 through 6 are transmembrane proteins; and class 7 is membrane associated via glycosylphosphatidylinositol (GPI) linkage. Plexins are a large family of transmembrane proteins, which are divided into four types (A-D) according to sequence similarity. In vertebrates, type A plexins serve as co-receptors for neuropilins to mediate the signalling of class 3 semaphorins. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B plexins. This family also includes the MET and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves to recognize and bind receptors.


Pssm-ID: 200495 [Multi-domain]  Cd Length: 392  Bit Score: 89.19  E-value: 1.16e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 231 DDDKVYFFFRERAVesdcyaeqVVARVARVCKGDMGGARTLqrkwttflkarLACSAPNWQLYFNQLQ-AMHTLQDTSWH 309
Cdd:cd09295    1 DDDKILVSFRKDTI--------YVGAIARIYKVDGGGTRLL-----------LSCISPELNFGFNEDQkAFCPLRRGKWT 61
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 310 NTTFFGVFQAQWGDMYLSAICEYQLEE-IQRVFEGPYKEYHEEAQKwdrytdpvPSPRPGSCINNWHRRHGYTSslelpD 388
Cdd:cd09295   62 ECINYIKVLQQKGDLDILAVCGSNAAQpSCGSYRLDVLVELGKVRW--------PSGRPRCPIDNKHSNMGVNV-----D 128
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 389 NILNFVKKHPLMEEqvgprwSRPLLVKKGTN--FTHLVADRVTGLDGATYTVLFIGTGDgwllkavslgpwvhlIEELQL 466
Cdd:cd09295  129 SKLYSATDHDFKDG------DRPALSRRSSNvhYLRIVVDSSTGLDEITFVYAFVSGDD---------------DDEVYF 187
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767918617 467 FDQEPMrslVLSQSKKLLFAGSRSQLVQLPVADCMKYRSCADCVLARDPYCAWS 520
Cdd:cd09295  188 FFRQEP---VEYLKKGMVYVPRIARVCKLDVGGCHRLKKKLTSFLKADLNCSRP 238
Ig_Semaphorin_C cd04979
Immunoglobulin (Ig)-like domain at the C-terminus of semaphorins; The members here are ...
561-633 5.93e-12

Immunoglobulin (Ig)-like domain at the C-terminus of semaphorins; The members here are composed of the immunoglobulin (Ig)-like domain in semaphorins. Semaphorins are transmembrane protein that have important roles in a variety of tissues. Functionally, semaphorins were initially characterized for their importance in the development of the nervous system and in axonal guidance. Later they have been found to be important for the formation and functioning of the cardiovascular, endocrine, gastrointestinal, hepatic, immune, musculoskeletal, renal, reproductive, and respiratory systems. Semaphorins function through binding to their receptors and transmembrane semaphorins also serves as receptors themselves. Although molecular mechanism of semaphorins is poorly understood, the Ig-like domains may be involved in ligand binding or dimerization.


Pssm-ID: 409368  Cd Length: 88  Bit Score: 62.09  E-value: 5.93e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767918617 561 TPKNITVVAGTDLVLPCHLSSNLAHARWTFGGRDLPAEQPGSFLYDARlQALVVMAAQPRHAGAYHCFSEEQG 633
Cdd:cd04979    2 SFKQISVKEGDTVILSCSVKSNNAPVTWIHNGKKVPRYRSPRLVLKTE-RGLLIRSAQEADAGVYECHSGERV 73
Sema_plexin_B cd11245
The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin ...
62-498 8.56e-12

The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin domains, function as receptors of semaphorins and may be the ancestors of semaphorins. There are three members of the Plexin B subfamily, namely B1, B2 and B3. Plexins B1, B2 and B3 are receptors for Sema4D, Sema4C and Sema4G, and Sema5A, respectively. The activation of plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Plexin B3, the receptor of Sema5A, is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Small GTPases play important roles in plexin B signaling. Plexin B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200506 [Multi-domain]  Cd Length: 440  Bit Score: 68.03  E-value: 8.56e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  62 TGLLYVGAREALFAFSMEaLELQGAISwEAPVEKKTECI------QKGKNNQTECFNFIRFLQPYNAShLYVCGTyAFQP 135
Cdd:cd11245   11 TGRLYLGAVNGLFQLSPN-LQLESRAD-TGPKKDSPQCLppitaaECPQAKETDNFNKLLLVNSANGT-LVVCGS-LFQG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 136 KCTYVNMltftlehGEFE------DGKGKCPY----DPAKGHAG----------LLVDGELYSATLNNflGTEPIILRNM 195
Cdd:cd11245   87 VCELRNL-------NSVNkplyrpETPGDKQYvaanEPSVSTVGlisyfkdglsLLFVGRGYTSSLSG--GIPPITTRLL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 196 GPHHSMkteylAFWLNEPH---FVGSA--YVPESVGSFTgDDDKVYFFFRERAVESDcyaEQVVARVARVCKGDmggart 270
Cdd:cd11245  158 QEHGEM-----DAFSNEVEaklVVGSAsrYHHDFVYAFA-DNGYIYFLFSRRPGTAD---STKRTYISRLCEND------ 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 271 lqRKWTTFLKARLACSAPNWQLYfNQLQAMHTLQDTSW-HNTTFFGVFQAQWGDMYL----SAICEYQLEEIQRVFEGPY 345
Cdd:cd11245  223 --HHYYSYVELPLNCTVNQENTY-NLVQAAYLAKPGKVlNGKVLFGVFSADEASTAApdgrSALCMYPLSSVDARFERTR 299
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 346 KEYHEEAQKWDRYTDPVPSPRPGSCINNwhrrhgytsslELPDNIlnfVKKHPLMEEQV-GPRWSRPLLVKKG--TNFTH 422
Cdd:cd11245  300 ESCYTGEGLEDDKPETAYIEYNVKSICK-----------TLPDKN---VKAYPCGAEHTpSPLASRYPLAAKPilTRNDM 365
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 423 LVADRVTGLDGatYTVLFIGTGDGWLLKaVSLGPwvhliEELQLFDQEPM-------RSLVLSQSKKLLFAGSRSQLVQL 495
Cdd:cd11245  366 LTAVAVAVENG--HTIAFLGDSGGQLHK-VYLDP-----NHTDFYSTIPGdqdsavnKDLLFDSTLNHLYVMTGKKISKV 437

                 ...
gi 767918617 496 PVA 498
Cdd:cd11245  438 PVQ 440
Sema_plexin_B2 cd11276
The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor ...
56-497 6.98e-10

The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor plays important roles in neural tube closure and cerebellar granule cell development. Mice lacking Plexin B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C-Plexin B2 signaling modulates ureteric branching. Plexin B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin B2 results in renal hypoplasia and occasional double ureters. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200537 [Multi-domain]  Cd Length: 449  Bit Score: 62.10  E-value: 6.98e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  56 LTLTEPTGLLYVGAREALFAFSMEALELQGAISweAPVEKKTECIQKGKNNQ------TECFNFIRFLQPYNAShLYVCG 129
Cdd:cd11276   11 LVVDPQTGRVYLGAVNALYQLDADLQLESRVET--GPKKDNKKCTPPIEENQcteakmTDNYNKLLLLDSANKT-LVVCG 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 130 TYaFQPKCTYVNmLTFTLEHGEFEDGKGKCPYdPAKGHAGLLVDGELYSATLNN----FLGtepiilRNMGPHHSMK--- 202
Cdd:cd11276   88 SL-FKGICSLRN-LSNISEVIYYSDTSGEKSF-VASNDEGVSTVGLISSLKPGNdrvfFVG------KGNGSNDNGKiis 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 203 TEYLAFWLNEPHF--------VGSAYVPESVGSFT---GDDDKVYFFFRERAVESDcyaeQVVARVARVCKGDMGgartl 271
Cdd:cd11276  159 TRLLQNYDDREVFenyidaatVKSAYVSRYTQQFRyafEDNNYVYFLFNQQLGHPD----KNRTLIARLCENDHH----- 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 272 qrkWTTFLKARLACSAPNWQlyFNQLQAMH----------TLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVF 341
Cdd:cd11276  230 ---YYSYTEMDLNCRDGANA--YNKCQAAYvstpgkelaqNYGNSILSDKVLFAVFSRDEKDSGESALCMFPLKSINAKM 304
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 342 EGPYKE-YHEEAQKWDRYTDPVPSPRPGSCINnwHRRHGYTS----SLELPdnilnfvkkHPLMEEQvGPRWSRPLLVKK 416
Cdd:cd11276  305 EANREAcYTGTIDDRDVFYKPFHSQKDIICGS--HQQKNSKSfpcgSEHLP---------YPLGSRD-ELALTAPVLQRG 372
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 417 GTNFThlvADRVTGLDGatYTVLFIGTGDGWLLKavslgpwVHLIEELQLFDQEPM-------RSLVLSQSKKLLFAGSR 489
Cdd:cd11276  373 GLNLT---AVTVAVENG--HTVAFLGTSDGRILK-------VHLSPDPEEYNSILIeknkpvnKDLVLDKTLEHLYIMTE 440

                 ....*...
gi 767918617 490 SQLVQLPV 497
Cdd:cd11276  441 DKVFRLPV 448
Sema_plexin_A2 cd11272
The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor ...
426-526 1.42e-09

The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor for class 6 semaphorins. Interactions between Plexin A2, A4 and semaphorins 6A and 6B control the lamina-restricted projection of hippocampal mossy fibers. Sema6B also repels the growth of mossy fibers in a Plexin A4 dependent manner. Plexin A2 does not suppress Sema6B function. In addition, studies have shown that Plexin A2 may be related to anxiety and other psychiatric disorders. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200533 [Multi-domain]  Cd Length: 515  Bit Score: 61.49  E-value: 1.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 426 DRVTGLDGATY---TVLFIGTGDGWLLKAVSLGPwVH---LIEELQLF-DQEP-MRSLVLSQSKKLLFAGSRSQLVQLPV 497
Cdd:cd11272  393 DRLTSVASYVYngySVVFVGTKSGKLKKIRADGP-PHggvQYEMVSVFkDGSPiLRDMAFSIDHKYLYVMSERQVSRVPV 471
                         90       100
                 ....*....|....*....|....*....
gi 767918617 498 ADCMKYRSCADCVLARDPYCAWSVNTSRC 526
Cdd:cd11272  472 ESCEQYTTCGECLSSGDPHCGWCALHNMC 500
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
499-528 6.35e-09

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 52.16  E-value: 6.35e-09
                           10        20        30
                   ....*....|....*....|....*....|
gi 767918617   499 DCMKYRSCADCVLARDPYCAWSVNTSRCVA 528
Cdd:smart00423   1 RCSKYTSCSECLLARDPYCAWCSSQGRCTS 30
Sema_plexin_B1 cd11275
The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the ...
45-498 1.52e-08

The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D-plexin B signaling complex regulates dendritic and axonal complexity. The activation of Plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200536 [Multi-domain]  Cd Length: 461  Bit Score: 58.05  E-value: 1.52e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  45 FSQTGIQdFLTLTLTEPTGLLYVGAREALFAFSmEALELQGAIS----WEA----PVEKKTECIQKGKNNQTecfNFIRF 116
Cdd:cd11275    1 FSPNGTK-FLHLSMDPESGTLYLGATNFLFQLT-PDLLLENMVQtgpvLDSkdclPPVSKLECPQAQHTNNH---NKLLL 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 117 LQPyNASHLYVCGTyAFQPKCTYVNMLtfTLEHGEFE-DGKGKCPY----DPAKGHAGLLVDGELYSATLnnFL------ 185
Cdd:cd11275   76 VNP-VQKELIVCGS-VHQGICEKRRLG--SIDHVLFRpERPGDTQYvaanDPNVTTVGLVAYSKDGVPLL--FVgrgyts 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 186 -----GTEPIILRNMGPHHSMKTEYLAFWLNEPH---FVG--SAYVPESVGSFTgDDDKVYFFFRERAVESDCYAEQvvA 255
Cdd:cd11275  150 rgvggGIPPITTRNLRAHGDDATDSHSIFSYEETaklAVGrlSEYNHHFIKAFT-YGSSVYFLFYRRDLKSQSREYK--T 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 256 RVARVCKGDmggartlqRKWTTFLKARLACSAPNWQlyFNQLQAMHTLQDTSW--------HNTTFFGVFqAQW-----G 322
Cdd:cd11275  227 YISRICLDD--------SHYYSYVELPLLCQSKANT--YSLLQAAYVTQPGERlaqgqldtDGEVLFAAF-SAWqassgK 295
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 323 DMYLSAICEYQLEEIQRVF----------EGPYKEYHEEAQ-KWDRYTDPVPSPRPGSCINNWHRRHgyTSSlelPdnil 391
Cdd:cd11275  296 LSEESALCAYPMDEVDRLTnwtrdvcytrDGKAEDGTEVAYiEYDVSSNCVQLPADTLDAYPCGSDH--TPS---P---- 366
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 392 nfvkkhplMEEQVgPRWSRPLLVKKGTNFThlvADRVTGLDGatYTVLFIGTGDGWLLKaVSLGPW--VHLIEELQ-LFD 468
Cdd:cd11275  367 --------MASRV-PLEATPLLEWTEIRLT---AVAVNVEDG--HTIAFLGDSRGRLHK-VYLGAGgdAHTYSSQSiQQN 431
                        490       500       510
                 ....*....|....*....|....*....|
gi 767918617 469 QEPMRSLVLSQSKKLLFAGSRSQLVQLPVA 498
Cdd:cd11275  432 SAVSGDLLFDQLQEHLYVMTQSTVLKVPIA 461
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
499-527 3.07e-08

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 50.40  E-value: 3.07e-08
                          10        20
                  ....*....|....*....|....*....
gi 767918617  499 DCMKYRSCADCVLARDPYCAWSVNTSRCV 527
Cdd:pfam01437   1 RCSQYTSCSSCLAARDPYCGWCSSEGRCV 29
Ig_Sema4D_like cd05873
Immunoglobulin (Ig)-like domain of semaphorin 4D (Sema4D) and similar proteins; The members ...
562-632 6.31e-07

Immunoglobulin (Ig)-like domain of semaphorin 4D (Sema4D) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain of semaphorin 4D (Sema4D) and similar proteins. Sema4D is a Class IV semaphorin. Semaphorins are classified based on structural features additional to the Sema domain. Sema4D has extracellular Sema and Ig domains, a transmembrane domain, and a short cytoplasmic domain. Sema4D plays a part in the development of GABAergic synapses. Sema4D in addition is an immune semaphorin. It is abundant on resting T cells; its expression is weak on resting B cells and antigen presenting cells (APCs), but is upregulated by various stimuli. The receptor used by Sema4D in the immune system is CD72. Sem4D enhances the activation of B cells and DCs through binding CD72, perhaps by reducing CD72s inhibitory signals. The receptor used by Sema4D in the non-lymphatic tissues is plexin-B1. Sem4D is anchored to the cell surface but its extracellular domain can be released from the cell surface by a metalloprotease-dependent process. Sem4D may mediate its effects in its membrane-bound form and/or its cleaved form.


Pssm-ID: 409457  Cd Length: 87  Bit Score: 47.89  E-value: 6.31e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767918617 562 PKNITVVAGTDLVLPCHLSSNLAHARWTFGGRDLPAEQPGSFLYDarlQALVVMAAQPRHAGAYHCFSEEQ 632
Cdd:cd05873    3 PRQRTFKLGGNAELKCSPKSNLARVVWKFQGKVLKAESPKYGLYG---DGLLIFNASEADAGRYQCLSVEK 70
Sema_plexin_B3 cd11277
The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of ...
56-498 3.18e-06

The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The stimulation of plexin B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200538 [Multi-domain]  Cd Length: 434  Bit Score: 50.58  E-value: 3.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617  56 LTLTEPTGLLYVGAREALFAFSMEaLELQGAIS----WEAP----VEKKTECIQKGKNNQTECFnfirFLQPYNASHLYV 127
Cdd:cd11277   11 LALDPGSGTLYVGAVNRLYQLSPD-LQLLGEAVtgpvLDSPdclpFRDPADCPQARLTDNANKL----LLVSERAGELVA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 128 CGTyAFQPKCTY-----VNMLTFTLEhgEFEDGKGKCPYDP----------AKGHAGLLVdGELYSATLNNflGTEPIIL 192
Cdd:cd11277   86 CGQ-VRQGVCEKrrlgnVAQVLYQAE--DPGDGQFVAANDPgvatvglvveAPGRDLLLV-GRGLTGKLSA--GIPPLTI 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 193 RNMGPHHSMKTEYLAFWLnephfVG--SAYVPESVGSFTgDDDKVYFFFRERAVESdcyaeQVVAR--VARVCKGDMgga 268
Cdd:cd11277  160 RQLAGAQAFSSEGLGKLV-----VGdfSDYNNSYVGAFA-HNGYVYFLFRRRGARA-----QAEYRtyVARVCLGDT--- 225
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 269 rtlqrKWTTFLKARLACsapnwQLYFNQLQAMHtlqdTSWHNTTFFGVFQAQWGDMYL----SAICEYQLEEIQRVFEGP 344
Cdd:cd11277  226 -----NLYSYVEVPLVC-----QGGYNLAQAAY----LAPGQGTLFVVFAAGQGSTPTptdqTALCAYPLVELDSAMERA 291
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 345 YKEYHEEAQKwdrytdpVPSPRPGSCInnwhrRHGYTSS-LELPDNILnfvKKHPLMEEQV-GPRWSR------PLLvkk 416
Cdd:cd11277  292 RRLCYTAGGG-------GPNGKEEATI-----EYGVTSRcVNLPKDSP---ESYPCGDEHTpSPIASRqpleaePLL--- 353
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 417 gTNFTHLVAdrVTGLDGATYTVLFIGTGDGWLLKAVSLGPWVHLIEELQLfdqEPMRS-----LVLSQSKKLLFAGSRSQ 491
Cdd:cd11277  354 -TLTPPLTA--VAALQEDGHTIAFLGDTQGQLHKVFLNGSAGQVYSSQPV---GPPGSavnpdLLLDATGSHLYVLTARQ 427

                 ....*..
gi 767918617 492 LVQLPVA 498
Cdd:cd11277  428 VTKVPVA 434
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
562-627 1.43e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 41.34  E-value: 1.43e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767918617   562 PKNITVVAGTDLVLPCHLSSN-LAHARWTFGGRDLPAEQPG-SFLYDARLQALVVMAAQPRHAGAYHC 627
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSpPPEVTWYKQGGKLLAESGRfSVSRSGSTSTLTISNVTPEDSGTYTC 68
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
557-627 7.32e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 39.09  E-value: 7.32e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767918617  557 KVRPTPKNITVVAGTDLVLPCHLSSN-LAHARWTFGGRDLPAEQPGSFLYDARLQALVVMAAQPRHAGAYHC 627
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCEATGSpPPTITWYKNGEPISSGSTRSRSLSGSNSTLTISNVTRSDAGTYTC 74
I-set pfam07679
Immunoglobulin I-set domain;
562-627 8.49e-04

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 39.16  E-value: 8.49e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767918617  562 PKNITVVAGTDLVLPCHLSSN-LAHARWTFGGRDLPAEQPGSFLYDARLQALVVMAAQPRHAGAYHC 627
Cdd:pfam07679   7 PKDVEVQEGESARFTCTVTGTpDPEVSWFKDGQPLRSSDRFKVTYEGGTYTLTISNVQPDDSGKYTC 73
Ig6_Contactin-4 cd05853
Sixth immunoglobulin (Ig) domain of contactin-4; The members here are composed of the sixth ...
557-649 1.12e-03

Sixth immunoglobulin (Ig) domain of contactin-4; The members here are composed of the sixth immunoglobulin (Ig) domain of the neural cell adhesion molecule contactin-4. Contactins are neural cell adhesion molecules, and are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. The different contactins show different expression patterns in the central nervous system. Highest expression of contactin-4 is in testes, thyroid, small intestine, uterus, and brain. Contactin-4 plays a role in the response of neuroblastoma cells to differentiating agents, such as retinoids. The contactin 4 gene is associated with cerebellar degeneration in spinocerebellar ataxia type 16.


Pssm-ID: 409439  Cd Length: 102  Bit Score: 39.22  E-value: 1.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 557 KVRPTPKNITVVAGTDLVLPCHLSSNlaHA-----RWTFGGRDLPAEQPGSFLYDARLQA----LVVMAAQPRHAGAYHC 627
Cdd:cd05853    4 RVMVPPSSMDVTVGESIVLPCQVSHD--HSldivfTWSFNGHLIDFQKDGDHFERVGGQDsagdLMIRSIQLKHAGKYVC 81
                         90       100
                 ....*....|....*....|..
gi 767918617 628 FSEEQGARLAAEGYLvaVVAGP 649
Cdd:cd05853   82 MVQTSVDKLSAAADL--IVRGP 101
IgI_5_Dscam cd20958
Fifth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; ...
558-596 1.34e-03

Fifth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fifth immunoglobulin domain of the Drosophila melanogaster Down syndrome cell adhesion molecule (DSCAM) protein and similar proteins. Down syndrome cell adhesion molecule (DSCAM) is a cell adhesion molecule that plays critical roles in neural development, including axon guidance and branching, axon target recognition, self-avoidance and synaptic formation. DSCAM belongs to the immunoglobulin superfamily and contributes to defects in the central nervous system in Down syndrome patients. Vertebrate DSCAMs differ from Drosophila Dscam1 in that they lack the extensive alternative splicing that occurs in the insect gene. Drosophila melanogaster Dscam has 38,016 isoforms generated by the alternative splicing of four variable exon clusters, which allows every neuron in the fly to display a distinctive set of Dscam proteins on its cell surface. Drosophila Dscam1 is a cell-surface protein that plays important roles in neural development and axon tiling of neurons. It is shown that thousands of isoforms bind themselves through specific homophilic (self-binding) interactions, a process which mediates cellular self-recognition. Drosophila Dscam2 is also alternatively spliced and plays a key role in the development of two visual system neurons, monopolar cells L1 and L2. This group is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand.


Pssm-ID: 409550 [Multi-domain]  Cd Length: 89  Bit Score: 38.70  E-value: 1.34e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 767918617 558 VRPTPkNITVVAGTDLVLPCHLSSNLAHA-RWTFGGRDLP 596
Cdd:cd20958    4 IRPMG-NLTAVAGQTLRLHCPVAGYPISSiTWEKDGRRLP 42
Sema_plexin_A3 cd11273
The Sema domain, a protein interacting module, of Plexin A3; Plexin-A3 forms a receptor ...
423-497 2.34e-03

The Sema domain, a protein interacting module, of Plexin A3; Plexin-A3 forms a receptor complex with neuropilin-2 and transduces signals for class 3 semaphorins in the nervous system. Both plexins A3 and A4 are essential for normal sympathetic neuron development. They function cooperatively to regulate the migration of sympathetic neurons, and differentially to guide sympathetic axons. Both plexins A3 and A4 are not required for guiding neural crest precursors prior to reaching the sympathetic anlagen. Plexin A3 is a major driving force for intraspinal motor growth cone guidance. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200534 [Multi-domain]  Cd Length: 469  Bit Score: 41.46  E-value: 2.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 423 LVADRVTGLDG-ATYT-----VLFIGTGDGWLLKAVSLGPW-VHLIEELQLFDQEP-MRSLVLSQSKKLLFAGSRSQLVQ 494
Cdd:cd11273  386 LLADSTDGMASvAAYTyrqhsVVFIGTRSGSLKKVRVDGFQdAHLYETVPVVDGSPiLRDMVFSPDHRYIYLLSEKQVSQ 465

                 ...
gi 767918617 495 LPV 497
Cdd:cd11273  466 LPV 468
Ig6_Contactin cd04970
Sixth immunoglobulin (Ig) domain of contactin; The members here are composed of the sixth ...
557-649 4.66e-03

Sixth immunoglobulin (Ig) domain of contactin; The members here are composed of the sixth immunoglobulin (Ig) domain of contactins. Contactins are neural cell adhesion molecules and are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. The first four Ig domains form the intermolecular binding fragment, which arranges as a compact U-shaped module via contacts between Ig domains 1 and 4, and between Ig domains 2 and 3. Contactin-2 (TAG-1, axonin-1) may play a part in the neuronal processes of neurite outgrowth, axon guidance and fasciculation, and neuronal migration. This group also includes contactin-1 and contactin-5. The different contactins show different expression patterns in the central nervous system. During development and in adulthood, contactin-2 is transiently expressed in subsets of central and peripheral neurons. Contactin-5 is expressed specifically in the rat postnatal nervous system, peaking at about 3 weeks postnatal, and a lack of contactin-5 (NB-2) results in an impairment of neuronal activity in the rat auditory system. Contactin-5 is highly expressed in the adult human brain in the occipital lobe and in the amygdala. Contactin-1 is differentially expressed in tumor tissues and may, through a RhoA mechanism, facilitate invasion and metastasis of human lung adenocarcinoma.


Pssm-ID: 409359  Cd Length: 102  Bit Score: 37.53  E-value: 4.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918617 557 KVRPTPKNITVVAGTDLVLPCHLSSNLAHA---RWTFGGRDLPAEQP-GSFLYDARLQA---LVVMAAQPRHAGAYHCFS 629
Cdd:cd04970    4 RITLAPSNADITVGENATLQCHASHDPTLDltfTWSFNGVPIDLEKIeGHYRRRYGKDSngdLEIVNAQLKHAGRYTCTA 83
                         90       100
                 ....*....|....*....|
gi 767918617 630 EEQGARLAAEGYLvaVVAGP 649
Cdd:cd04970   84 QTVVDSDSASATL--VVRGP 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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