|
Name |
Accession |
Description |
Interval |
E-value |
| SLC5sbd_CHT |
cd11474 |
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding ... |
14-411 |
6.48e-173 |
|
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Na+/choline co-transport by CHT is Cl- dependent. Human CHT (also called CHT1) is encoded by the SLC5A7 gene, and is expressed in the central nervous system. hCHT1-mediated choline uptake may be the rate-limiting step in acetylcholine synthesis, and essential for cholinergic transmission. Changes in this choline uptake in cortical neurons may contribute to Alzheimer's dementia. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271368 [Multi-domain] Cd Length: 464 Bit Score: 494.74 E-value: 6.48e-173
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 14 GGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDMHISVIISALIATLYTL 93
Cdd:cd11474 83 GGLFFAKPMRRMGLLTLGDFFRQRYGRRVEVLLSIPAVLSYLGWVAAQLVALGLVLSVILGLPVETGILISAAIVLAYTL 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 94 VGGLYSVAYTDVVQLFCIFVGLWISVPFALSHPAVADIG-FTAVHAKYQKPWLGTVdsSEVYSWLDSFLLLMLGGIPWQA 172
Cdd:cd11474 163 FGGMWSVAYTDVVQLIVIFVGLLVLVPFVLTNPGGVDIAsAAAAGKLRFFPWLGTK--SDWLIWIDAWLTLGLGSIPQQD 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 173 YFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNQTAYGLPDpktteEADMILPIVLQYLCPVYISFFG 252
Cdd:cd11474 241 VFQRVLSAKSEKTAQRLSLLAGVGYLLFAIPPLLIGLAAASIDPSLTQYGLEE-----DAQLILPLLLQYLTPLWVQVLF 315
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 253 LGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWYLSSDLVYIV 332
Cdd:cd11474 316 LGALLSAVMSTADSALLAPSSVFSENIYKPPFRPKASDRELLWVMRISVVVFGAIATLMALTVESIYGLVELASDLVLVG 395
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767919123 333 IFPQLLCVLFVKGTNTYGAVAGYVSGLFLRITGGEPYLYLQPlifypgyypdDNGIYNQKFPFKTLAMVTSFLTNICIS 411
Cdd:cd11474 396 LFVPLLAGLYWKRANTYGALAAIIVGLVLRLLGGELLLGLPA----------DIPPQLQGFPFSTLAMVIGSLLPLAVS 464
|
|
| PutP |
COG0591 |
Na+/proline symporter [Amino acid transport and metabolism]; |
15-383 |
8.53e-64 |
|
Na+/proline symporter [Amino acid transport and metabolism];
Pssm-ID: 440356 [Multi-domain] Cd Length: 476 Bit Score: 214.68 E-value: 8.53e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 15 GLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDMHISVIISALIATLYTLV 94
Cdd:COG0591 88 ALFFAPRLRRLGALTIPEFLEKRFGRGLRLLAAIIILLFLLGYLAAQLVALGKLLEALFGIPYWLGILIGALIVLLYTVL 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 95 GGLYSVAYTDVVQLFCIFVGLWISVPFALSHPAvadiGFTAVHAKYQKP----WLGTVDSSEVYSWLDSFLLLMLGGIPW 170
Cdd:COG0591 168 GGLRAVAWTDVLQGILMLVGLILLLIVALSALG----GFGELFAALPAPgllsLFPGLGFTGWLAFLGLFLAIGLGYFGQ 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 171 QAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIgastdwnqtAYGLPDPKTTEEADMILPIVLQYLCPVYISF 250
Cdd:COG0591 244 PHIVQRFLAAKSEKEARKAALIGGLLYLLFYLLAALIGLL---------ARALFPDLPLADPDLALPLLILELLPPGLAG 314
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 251 FGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTK-TVYGLWYLSSDLV 329
Cdd:COG0591 315 LLLAAILAAAMSTADSQLLAASSVFTRDIYKPFIKPKASDKQLLRVSRLAVLVVGLLALLLALLFPsSILDLVLLAWGGL 394
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 767919123 330 YIVIFPQLLCVLFVKGTNTYGAVAGYVSGLFLRITGgepYLYLQPLIFYPGYYP 383
Cdd:COG0591 395 GAALLPPLLLGLFWKRATKAGALAGMIAGLVVVLLW---KLLGGPLGPFGWLYP 445
|
|
| SLC5sbd |
cd10322 |
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding ... |
15-383 |
5.64e-63 |
|
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.
Pssm-ID: 271357 [Multi-domain] Cd Length: 454 Bit Score: 211.64 E-value: 5.64e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 15 GLFFAKPMRSKGYVTMLD-PFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDMHISVIISALIATLYTL 93
Cdd:cd10322 85 ALFLAPRLRRLGKTTIPEtILERYYSKGLRLLVAIIIIIALIPYLALQLIGGGYILSTLLGIPYTVAVIIAAVIVILYTV 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 94 VGGLYSVAYTDVVQLFCIFVGLWISVPFALSHPAVADIGFTAVHAKYQKPWLGTVDSSEVYSWLDSFLLLMLGGIPWQAY 173
Cdd:cd10322 165 FGGMRAVAWTDVIQGIVMLIGVLVAAIFILSKVGGGGFSALAAALPALLLALGPGGGLGWSTILSLILLTGLGVLALPQV 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 174 FQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNqtayglpdpktTEEADMILPIVLQYLCPVYISFFGL 253
Cdd:cd10322 245 FQRILAAKDEKTARRAFLLAGLLLLLIGFLVALIGLAARALFPD-----------LENPDLALPTLINSLLPPGLAGLVL 313
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 254 GAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWYLSSDLVYIVI 333
Cdd:cd10322 314 AGLLAAAMSTADSLLLAASTLFTRDIYKPLINPKASDKKLLRVSRIAVVVVGVLALLLALLPPSILLLLSLAAGLLAAAL 393
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 767919123 334 FPQLLCVLFVKGTNTYGAVAGYVSGLFLRItggepYLYLQPLIFYPGYYP 383
Cdd:cd10322 394 FPPLLGGLFWKRATKAGAIAGIIVGLIVTL-----VWLLLPLASPLGIDP 438
|
|
| YidK |
COG4146 |
Uncharacterized membrane permease YidK, sodium:solute symporter family [General function ... |
15-361 |
1.18e-30 |
|
Uncharacterized membrane permease YidK, sodium:solute symporter family [General function prediction only];
Pssm-ID: 443317 [Multi-domain] Cd Length: 444 Bit Score: 123.71 E-value: 1.18e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 15 GLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMF-WAAAIFSALGATISVIIDVDMHISVIISALIATLYTL 93
Cdd:COG4146 92 ALFFLPFYLKSGIYTMPEFLEKRYDRRTRTILSILFLVSYVFvNLPSVLYAGALALNTIFGVPLWISVIGLGIIAGIYTI 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 94 VGGLYSVAYTDVVQLFCIFVGLWISVPFALShpAVADIGF-------TAVHAKYQKPWLGtvDSSEVYSWLDSFLLLMLG 166
Cdd:COG4146 172 FGGLKAVAYTDVIQGIGLIIGGLLITVLGLD--AVGDGSVlagwsalLKVPPEKFNMIGP--ADDPDLPWLGIFTGMPIL 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 167 GIP-W---QAYFQRVLSSSSATYAQVLSFLAAFgcLVMAIPAILI--GAIgastdwnqtAYGLpDPKTTEEADMILPIVL 240
Cdd:COG4146 248 NLFyWgtnQYIVQRALGAKNLKEAQKGVLFAGF--LKLLIPFIVVlpGII---------AFVL-FPDGLDNPDQAYPTLV 315
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 241 QYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYG 320
Cdd:COG4146 316 KNLLPVGLKGLVAAALFAAIMSSLASALNSSSTLFTLDIYKKYFNPNASEKQLVKVGRIATVVLAVIAILIAPLIGNADG 395
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 767919123 321 LW-YLSSdlVYIVIFPQLLCV----LFVKGTNTYGAVAGYVSGLFL 361
Cdd:COG4146 396 LFqYIQE--VTGFFSPPILAVfllgLFWKRVTAKAAKVALIAGIVL 439
|
|
| SLC5sbd_PutP |
cd11475 |
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli ... |
16-360 |
7.82e-29 |
|
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli PutP catalyzes the Na+-coupled uptake of proline with a stoichiometry of 1:1. The putP gene is part of the put operon; this operon in addition encodes a proline dehydrogenase, allowing the use of proline as a source of nitrogen and/or carbon. This subfamily also includes the Bacillus subtilis Na+/proline cotransporter (OpuE) which has an osmoprotective instead of catabolic role. Expression of the opuE gene is under osmotic control and different sigma factors contribute to its regulation; it is also a putative CcpA-activated gene. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271369 Cd Length: 464 Bit Score: 118.77 E-value: 7.82e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 16 LFFAKPMRS----KGYVTMLDPFQQIYGKRMGGLLFIPALM---GEMFWAAAIFSALGATISVIIDVDMHISVIISALIA 88
Cdd:cd11475 84 LFVAKRLRRytekNDSITLPDYLENRFRDKSKLLRILSALIiliFFTIYAAAQLVAGGKLFESLFGIDYSTGLLIGAVVV 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 89 TLYTLVGGLYSVAYTDVVQLFCIFVGLwISVPFAlshpAVADIG-FTAVHAKyqkpwLGTVDSSEVYSWLDSFLLLMLGG 167
Cdd:cd11475 164 VAYTFLGGFLAVSWTDFFQGLLMLLAL-VLVPIV----ALAALGgLSGLVAA-----LAAIDPGLLSPFGGDLGAGGLLA 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 168 IPWQA-----YF------QRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGAstdwnqtAYgLPDPkTTEEADMIL 236
Cdd:cd11475 234 IISLLawglgYFgqphilVRFMAIRSPKEIKKARRIAMVWMILFLLGAVLVGLLGR-------AL-FPDG-LLGDPETVF 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 237 PIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALltk 316
Cdd:cd11475 305 PVLAQELFPPWLAGILLAAILAAIMSTADSQLLVCSSALTEDLYKAFLRKEASDKELVWVSRLAVLVIALIALLIAL--- 381
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 767919123 317 tvyglwYLSSDLVYIVIF----------PQLLCVLFVKGTNTYGAVAGYVSGLF 360
Cdd:cd11475 382 ------NPPSSVFSLVSFawaglgaafgPLLLLSLYWKRTTRQGALAGMIAGAV 429
|
|
| sss |
TIGR00813 |
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ... |
14-358 |
1.15e-28 |
|
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273282 [Multi-domain] Cd Length: 407 Bit Score: 117.40 E-value: 1.15e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 14 GGLFFAKPMRSKGYVTMLDPFQQIYGKR----MGGLLFIPALMGEMfwAAAIFSAlGATISVIIDVDMHISVIISALIAT 89
Cdd:TIGR00813 52 LGWLFVPIFINNGAYTMPEYLEKRFGKRilrgLSVLSLILYIFLYM--SVDLFSG-ALLIELITGLDLYLSLLLLGAITI 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 90 LYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFALShpavaDIGFT-AVHAKYQKPWLGTVDSSEVY------SWLDSFLL 162
Cdd:TIGR00813 129 LYTVFGGLKAVVWTDTIQAVIMILGTFILPVFAFS-----EVGGLgTFVEKASQAAPTNPSPDDLYdffrdpSTSDLPWG 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 163 LMLGGIPW--------QAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGAS--TDWNQtaygLPDPKTTEEA 232
Cdd:TIGR00813 204 AGVFGLPHvalwywtnQVIVQRCLAAKSAKHAKKGCLISGVLKLLPMFGAVLPGLIARAlyTDIDP----ALAGAVNQNS 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 233 DMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNAS-DKEIVWVMRITVFVFGASA-TA 310
Cdd:TIGR00813 280 DQAYPLLVQELMPPGLAGLFLAAILAAVMSTLSSQLNSASTVFTMDLYKKIIRPNASgEKKIVMRGRIAVLVAAVIAgFV 359
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 767919123 311 MALLTKTVYGLWYLSSDLVYIVIFPQLLCVLFVKGTNTYGAVAGYVSG 358
Cdd:TIGR00813 360 AAAQGGQVLQYVQEAFGGLGAPFLPVFLLGIFWKRMNAKGALAGMIAG 407
|
|
| SLC5sbd_u1 |
cd11477 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
43-379 |
2.08e-24 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271371 Cd Length: 493 Bit Score: 106.13 E-value: 2.08e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 43 GGLLFIPALMGEMFWAAAIFSAlgatisVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFA 122
Cdd:cd11477 125 FALLSNVDILAWVFLAAIKVSA------VFGPWDPWLTILILGLITLIYTVIGGLWAVVVTDVVQFVIAMAASIAVAVLA 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 123 LSHPAvadiGFTAVHAKYQKPWLGTVDSSEVYSWLDSFLLLML---------GGIPWqAYFQRVLSSSSATYA-QVLSFL 192
Cdd:cd11477 199 LNAVG----GPGGLFAQLPEGHLDLFGSGLGASGFYITFFFILffgwyplsySGGGW-YLAQRYLSAKSEKAAkAAAWLF 273
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 193 AAfgcLVMAIPAILIGAIGASTDWNqtaYGLPDPKTTEEAdmILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSAS 272
Cdd:cd11477 274 AA---LYLVRPWPWMLPALAALVLY---PDLDDPEADFEL--AYPMMIKEYLPAGLLGLVLAGLLAATMSTVSTHLNWGA 345
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 273 SMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWYLSSDLVYIVIFPQLLCV---LFVKGTNTY 349
Cdd:cd11477 346 AYLVNDIYKRFIKPNASEKHLLKVGRLATVLFGLLSIVVALASDSIGGAFWIVLALGAGLGGPLILPWlwwRFNAWTEIW 425
|
330 340 350
....*....|....*....|....*....|
gi 767919123 350 GAVAGYVSGLFLRITGGEPYLYLQPLIFYP 379
Cdd:cd11477 426 AMIASIIVGLVVSVLLKVFGLPEDFLFSFL 455
|
|
| SLC5sbd_DUR3 |
cd11476 |
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is ... |
38-411 |
1.28e-23 |
|
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is the yeast plasma membrane urea transporter. Saccharomyces cerevisiae DUR3 also transports polyamine. The polyamine uptake of S. cerevisiae DUR3 is activated upon its phosphorylation by polyamine transport protein kinase 2 (PTK2). S. cerevisiae DUR3 also appears to play a role in regulating the cellular boron concentration. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271370 Cd Length: 493 Bit Score: 103.44 E-value: 1.28e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 38 YGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWI 117
Cdd:cd11476 115 YGTAAHLVFLVFALFTNVIVLAMLLLGGSAVVNALTGMPIVAASFLIPLGVLLYTLFGGLRATFLTDYIHTVIILIILLV 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 118 SVPFALSHpavADIG-FTAVHAKYQKPWLGTVDSSEVYSWLD--------SFLLLMLGG----IPWQAYFQRVLSSSSAT 184
Cdd:cd11476 195 FAFAVYTS---SDIGsPSKVYDLLQEAAPDLPVEGNQGSYLTfkskagliFGIINIVGNfgtvFLDQGYWQRAIAARPSA 271
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 185 YAQVlSFLAafGCLVMAIPAILIGAIGASTdwnqTAYGLPDPKTTEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSA 264
Cdd:cd11476 272 AVKG-YFLG--GLAWFAIPFLLATTLGLAA----LALGLNPTFEEVSAGLVLPYVAAALLGKGGAAAVLVLLFMAVTSTA 344
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 265 DSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALltktvyGLWYLSSDLVYI----------VIF 334
Cdd:cd11476 345 SAELIAVSSIVTYDIYRTYINPNATGKQLLRVSRIAVIGFGLFMGGLAV------GLNYIGISLGWLllfmgiligsAVF 418
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767919123 335 PqLLCVLFVKGTNTYGAVAGYVSGLflrITGgepylylqpLIFYPGYYPDDNGIYNQKFPFKTLAMVTSFLTNICIS 411
Cdd:cd11476 419 P-VALGLYWRRQTGTAAVVSPIAGL---VAG---------LAVWLVTAKSYYGEVNVDTTGGNYPMLAGNLVALFSP 482
|
|
| SSF |
pfam00474 |
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ... |
15-358 |
1.25e-22 |
|
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.
Pssm-ID: 109527 [Multi-domain] Cd Length: 406 Bit Score: 99.72 E-value: 1.25e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 15 GLFFAKPMRSKGYVTMLDPFQQIYGKR--------MGGLLFIPALMGEMFWAAAIFsalgatISVIIDVDMHISVIISAL 86
Cdd:pfam00474 56 LWLFAPRLRNLGAYTMPDYLRKRFGGKrilvylsaLSLLLYFFTYMSVQIVGGARL------IELALGLNYYTAVLLLGA 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 87 IATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFALSHPAvadiGFTAVHAKYQKPWLGTVDSSEVYSW--------LD 158
Cdd:pfam00474 130 LTAIYTFFGGFLAVSWTDTIQAVLMLFGTIILMIIVFHEVG----GYSSAVEKYMTADPNGVDLYTPDGLhilrdpltGL 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 159 SF-LLLMLGGIPWQAYFQRVLSSSSATYAqVLSFLAAFGCLVMaipaILIGAIGASTDWNQTAYGLPDPKTTE--EADMI 235
Cdd:pfam00474 206 SLwPGLVLGTTGLPHILQRCLAAKDAKCI-RCGVLILTPMFII----VMPGMISRGLFAIALAGANPRACGTVvgCSNIA 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 236 LPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQN-ASDKEIVWVMRITVFVFGASATAMALL 314
Cdd:pfam00474 281 YPTLAVKLGPPGLAGIMLAVMLAAIMSTLTSQLLSSSSAFTHDLYKNIRRKAsATEKELVGRSRIIVLVVISLAILLAVQ 360
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 767919123 315 TKTVYGLWYLSSDLVYI--VIFPQLLCVLFVKGTNTYGAVAGYVSG 358
Cdd:pfam00474 361 PAQMGIAFLVQLAFAGLgsAFLPVILLAIFWKRVNEQGALWGMIIG 406
|
|
| SLC5sbd_SGLT1-like |
cd10329 |
Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily ... |
15-413 |
9.11e-22 |
|
Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily includes the solute-binding domain of SGLT proteins that cotransport Na+ with various solutes. Its members include: the human glucose (SGLT1, -2, -4, -5 ), chiro-inositol (SGLT5), and myo-inositol (SMIT) cotransporters. It also includes human SGLT3 which has been characterized as a glucose sensor and not a transporter. It belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271363 Cd Length: 538 Bit Score: 98.42 E-value: 9.11e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 15 GLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMF-WAAAIFSALGATISVIIDVDMHISVIISALIATLYTL 93
Cdd:cd10329 84 GWVFLPFYIRSGVSTMPEFLEKRFGGRSRVYLSVLSLILYVFtKISVDLYAGALVIKQLLGWDLYLSIIVLLVITAIYTI 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 94 VGGLYSVAYTDVVQLFCIFVGLWISVPFALSHpavADIGFTAVHAKY-QKPWLGTV--DSSEVYSWLDSFLLLMLGGIpW 170
Cdd:cd10329 164 AGGLKAVIYTDTLQAVILIIGSAILMFLAFNE---VGGGWSAYMAAIpSGTAFHLFrpPDDPDLPWPGLLLGYPILGI-W 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 171 -----QAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNQTAYGLPDPKTTEEADMILPIVLQYLCP 245
Cdd:cd10329 240 ywctdQVIVQRVLAAKNLKHARRGALFAGYLKLLPLFLMVLPGMIARALFPDLVACVVPCGNGVGCSDIAYPTLVTELLP 319
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 246 VYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLsFRQNASDKEIVWVMRI-TVFVFGASATAMALLTKTVYGLW-Y 323
Cdd:cd10329 320 VGLRGLVLAVLLAALMSSLTSIFNSASTLFTMDIYKR-LRPEASEKELVRVGRIaTLVVVVISILWAPIIQAQGGSLFnY 398
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 324 LSSDLVYIVifPQLLCV----LFVKGTNTYGAVAGYVSGLFLRITGGEPYLYLQPLIFYPGYYPDDNGIYnqkfpFKTLA 399
Cdd:cd10329 399 IQSVLSYLA--PPIAAVfllgIFWKRTNEQGAFWGLIAGLVLGLVRLILEFAYGEPDTRPAIIGGIHFLY-----FAFLL 471
|
410
....*....|....
gi 767919123 400 MVTSFLTNICISYL 413
Cdd:cd10329 472 FVVSVIVTVIVSLL 485
|
|
| SLC5sbd_u3 |
cd11479 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
15-358 |
2.15e-21 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271373 Cd Length: 454 Bit Score: 96.52 E-value: 2.15e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 15 GLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDMHISVIISALIATLYTLV 94
Cdd:cd11479 85 SLLLAKRIARLKVYTVSEVLELRYGPSARVISALVMLAYTLMVAVTSTIAIGTVFSVLFGLPRTLSILVGGGIVVLYSVL 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 95 GGLYSVAYTDVVQLFCIFVGLW-ISVPFALSHPAvadiGFTAVHAKYQKPW--LGTVDSSEVYSWldsFLLLMLGGIPWQ 171
Cdd:cd11479 165 GGMWSITLTDIIQFVIKTIGIFlLLLPLALSKAG----GLSGLQEKLPASYfdLTSIGWDTIVTY---FLLYFFGILIGQ 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 172 AYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTdwnqtaygLPDPKTTEEAdmiLPIVLQYLCPVYISFF 251
Cdd:cd11479 238 DIWQRVFTARSEKVARWGGVAAGLYCVLYGVAGALIGMAAAVL--------LPDLANPQNA---FATMAQEVLPVGLRGL 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 252 GLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWYLSSDLVYI 331
Cdd:cd11479 307 VLAAALAAMMSTASGALLASSTVLTNDVLPRLRRKNESERSEVRLSRLFTLLLGVVVIVIAVLVNDVVAALTIAYAILVG 386
|
330 340
....*....|....*....|....*..
gi 767919123 332 VIFPQLLCVLFVKGTNTYGAVAGYVSG 358
Cdd:cd11479 387 GLLVPILGGLFWKRATGAGALASMVAG 413
|
|
| SLC5sbd_NIS-like_u2 |
cd11494 |
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
53-379 |
2.16e-19 |
|
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters, SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271385 [Multi-domain] Cd Length: 473 Bit Score: 90.74 E-value: 2.16e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 53 GEMFWAAAIFsalgatISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFALSHPAVAdiG 132
Cdd:cd11494 129 GVTIYAPAII------LSTILGWSLWLTILLIGGITIIYTVLGGIKAVIWTDVIQMVIIWAGLFIAFGLLLKLLPVG--F 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 133 FTAVHAKYQKPWLGTVDSSevYSWLDSFLLL--MLGGI-PWQAYF-------QRVLSSSSATYAQVLSFLAAFGCLVMAI 202
Cdd:cd11494 201 VDALLVAGKSGRLNALDFS--FDLSDTYTFWsgLIGGFfLYLSYFgtdqsqvQRYLTAKSIKEARKSLLLNGFLKFPMQF 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 203 PAILIGAI--------GASTDWNQTAYGLPDPKtteeaDMILPIVLQYLCPVYISFFgLGAVSAAVMSSADSSILSASSM 274
Cdd:cd11494 279 FILLIGVLvfvfyqfnPFPVSFNPAEDETKDTN-----YIFLRFVLNYLPPGVIGLL-IAAIFAAAMSSIDSALNSLATV 352
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 275 FARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMAL---LTKTVYGLWYLSSDLVYIVIFPQLLCVLFVKGTNTYGA 351
Cdd:cd11494 353 TVIDIYRRFFKKDASDEHYLKVSRLLTVFWGLLAIVFALfagLAGSLIEAVNKLGSLFYGPILGVFLLAFFTKKANGKGV 432
|
330 340
....*....|....*....|....*...
gi 767919123 352 VAGYVSGLFLRItggepYLYLQPLIFYP 379
Cdd:cd11494 433 FAGAILGVIVVI-----VLWLFPDVSWL 455
|
|
| SLC5sbd_u2 |
cd11478 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
53-415 |
3.93e-19 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271372 Cd Length: 496 Bit Score: 90.04 E-value: 3.93e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 53 GEMFWAAAIFsalgatISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFALSHPA----- 127
Cdd:cd11478 130 GINLYALALV------LNVLLGWPLWLSIILSAAIVLAYTTLGGLTSAIYNEVLQFFLIVAGLIPLVIIGLIKVGgwdgl 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 128 VADIGFTAVHAKYQKPWLGTVDSSEVYSWLDSFLLLMLGGIPWQAYF-------QRVLSSSSATYAQVLSFLAAFgcLVM 200
Cdd:cd11478 204 SEKIDANGPPGWNGLSWGPQGSQSTNPMGVNLGLVFGLGFVLSFGYWttnflevQRAMAAKDLSAARRTPLIAAF--PKM 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 201 AIPAILI--GAIGASTDWNQTAYGLPDPktteeaDMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARN 278
Cdd:cd11478 282 FIPFLVIlpGLIALVLVPELGASGGLDY------NQALPYLMAKYLPPGLLGLGITALLAAFMSGMAGNVSAFNTVFTYD 355
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 279 IYQLSFRQNASDKEIVWVMRITVFVfgasATAMALLTKtvyglwYLSSDLVYIVIFPQLLCVLFV-------------KG 345
Cdd:cd11478 356 IYQTYIVKDAPDKHYLKVGRIATVV----GVLISIGTA------YIASSFNNIMDYLQLLFSFFNaplfatfllgmfwKR 425
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 346 TNTYGAVAGYVSGlflriTGGEPYLYlqplIFYPGYYPDDNGIYNQKFPFKTLAMVTSFLTNICISYLAK 415
Cdd:cd11478 426 ATPWGGFWGLLAG-----TASAIVLY----GLYELGLIVYHSDMAPNFYGAWWAFVVCFVVTVLVSLLTK 486
|
|
| SLC5sbd_vSGLT |
cd10325 |
Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute ... |
15-361 |
1.14e-18 |
|
Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; vSGLT transports D-galactose, D-glucose, and alpha-D-fucose, with a sugar specificity in the order of D-galactose >D-fucose >D-glucose. It transports one Na+ ion for each sugar molecule, and appears to function as a monomer. vSGLT has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271360 Cd Length: 523 Bit Score: 88.90 E-value: 1.14e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 15 GLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGA-TISVIIDVDMHISVIISALIATLYTL 93
Cdd:cd10325 86 AKFFLPIFLKNGIYTMPQFLEERYDGRVRTIMAVFWLLLYVFVNLTSVLYLGAlAIETITGIPLTYSIIGLALFAAAYSI 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 94 VGGLYSVAYTDVVQLFCIFVGLWISVPFALSHPAVADIGFTAVHAKYQKPW------LGTVDSSEVYSWLDSfLLLMLGG 167
Cdd:cd10325 166 YGGLKAVAWTDVIQVVFLVLGGLVTTYIALSLLGGGEGVFAGFTLLAAEAPehfhmiLDKSNPEDAYKDLPG-IAVLLGG 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 168 IpWQAYF----------QRVLSSSSATYAQVLSFLAAFGCLVM----AIPAILIGAIGASTDwnqtaygLPDPKTTEEAD 233
Cdd:cd10325 245 L-WVANLsywgfnqyiiQRALAAKSLSEAQKGIVFAAFLKLLIpfivVIPGIAAYVLASNLL-------LPAATGIEKPD 316
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 234 MILPIVLQYLcPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMAL 313
Cdd:cd10325 317 QAYPWLLRNL-PTGLKGLVFAALTAAIVSSLASMLNSISTIFTMDIYKKYIPKKASEKQLVNVGRLAAVIALIIAALIAP 395
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 767919123 314 LtktvygLWYLSSDLVYI-----VIFPQLLCV----LFVKGTNTYGAVAGYVSGLFL 361
Cdd:cd10325 396 P------LLGLDQAFQYIqeytgFISPGILAIfllgLFWKRATSAGALVAAILSIVL 446
|
|
| SLC5sbd_NIS-like_u3 |
cd11495 |
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
41-359 |
2.47e-16 |
|
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271386 [Multi-domain] Cd Length: 473 Bit Score: 81.43 E-value: 2.47e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 41 RMGGLLFIPALMgemfwaaaifsalgatISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQ--------LFCIF 112
Cdd:cd11495 130 RMGIVLYLPALA----------------LSAVTGINPYIIIILMGVLCIIYTVLGGIEAVIWTDVIQgvvllggaLLCLI 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 113 VGLWiSVPFALSHpaVADIGFTAvhakyQKPWLGTVDSSEVYSwldSFLLLMLGGIPW--------QAYFQRVLSSSSAT 184
Cdd:cd11495 194 ILLF-SIPGGFGE--VFDIAIAN-----GKFSLGDFSFSLTES---TIWVIFIGGIFNnlqsytsdQDVVQRYLTTKSIK 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 185 YAQVLSFLAAfgclVMAIPAILI-GAIGAS--TDWNQTAyglPDPKTTEEADMILP-IVLQYLcPVYISFFGLGAVSAAV 260
Cdd:cd11495 263 EAKKSLWTNA----LLALPVALLfFGIGTAlyVFYQQHP---ELLPAGINGDAVFPyFIVTQL-PVGVAGLIIAAIFAAA 334
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 261 MSSADSSILSASSMFARNIYQlSFRQNASDKEIVWVMRITVFVFGASATAMALL-----TKTVYGLWYLSSDLVYIVIFP 335
Cdd:cd11495 335 MSTISSSLNSVATCITTDFYK-RLSPDPSDKQYLKVARLITLLVGLLGTLVALYlanagVKSLLDAFNTLTGLFGGGLAG 413
|
330 340
....*....|....*....|....
gi 767919123 336 QLLCVLFVKGTNTYGAVAGYVSGL 359
Cdd:cd11495 414 LFLLGIFTKRANAKGALVGIIVSI 437
|
|
| SLC5sbd_u4 |
cd11480 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
16-413 |
7.20e-16 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271374 Cd Length: 488 Bit Score: 79.86 E-value: 7.20e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 16 LFFAKPMRSKGYVTMLDpF--QQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDMHISVIISALIATLYTL 93
Cdd:cd11480 84 LLVAEPLRNFGKYTVPD-FlgARLGSRPVRLVAAVSTLVISFFYLVAQMVGAGLLLSLLLGIPYEVGVVVVGALMIVYVV 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 94 VGGLYSVAYTDVVQLFCIFVGL------------WISVPFALSHPAVADIGFTAVHAKYQKPWLGTVDSSEVYSWLdsfL 161
Cdd:cd11480 163 LGGMRATTWVQIIQYVLLLGAFlvpailvlarfgGNPLGAGPGLLGLAAAAASGAGEAYLAPGLLLTDPLDVISLT---L 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 162 LLMLG--GIPwqAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNQTAYGLPDPKTTEEADMILPIV 239
Cdd:cd11480 240 ALMLGtaGLP--HVLMRFYTVPDARAARKSVVWALGFIGLFYLLAPALGFGARALVGPDVIGAPIAGELDGGGDMAVLLL 317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 240 LQYLCPVYIsFFGL---GAVsAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTK 316
Cdd:cd11480 318 PEIAGLGDL-LLALvaaGAF-AAILATVAGLLLAAASALAHDLYAGVIRPGASERREVRVARIAAVVVGVIAILLALLFP 395
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 317 TvyglwylsSDLVYIV----------IFPQLLCVLFVKGTNTYGAVAGYVSGLFLRITggepYLYLQPLIFYPGYYPDDN 386
Cdd:cd11480 396 P--------QNVAFLValafaiaasaFFPVLVLGIFWRRFTTRGAIAGMLVGLLVSLV----LIVLSPAVSGAPPGHDFA 463
|
410 420 430
....*....|....*....|....*....|
gi 767919123 387 GiynqkFPFKTLAMVT---SFLTNICISYL 413
Cdd:cd11480 464 G-----FPLTNPGLVSvplGFLVAIVVSLL 488
|
|
| PanF |
COG4145 |
Na+/panthothenate symporter [Coenzyme transport and metabolism]; |
18-359 |
2.47e-15 |
|
Na+/panthothenate symporter [Coenzyme transport and metabolism];
Pssm-ID: 443316 Cd Length: 484 Bit Score: 78.34 E-value: 2.47e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 18 FAKPMRSKGYVTMLDPFQQIYGKR----MGGLLFIPALMGEMfwaAAIFSALGATISVIIDVDMHISVIISALIATLYTL 93
Cdd:COG4145 99 FAILGRKYNAVTLADWLRARYQSKalvlLAALLLLLFFIAFM---VAQFVGGARLLETVTGISYTTGLLIFGVTVVLYTT 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 94 VGGLYSVAYTDVVQLFCIFVGLWISVPFALshpaVADIGFTAV--HAKYQKPWLGT---VDSSEVYSWLDSF-LLLMLGG 167
Cdd:COG4145 176 IGGFRAVVLTDAIQGIIMLVGTVLLLIGVI----SAGGGIENImsTLAAIDPNLVSptgPDGFLPRPFVISFwILVGFGV 251
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 168 IPWQAYFQRVLSS-SSATYAQVLsFLAAFGCLVMAIPAILIGAIGASTdwnqtaygLPDpktTEEADMILPIVLQYLCPV 246
Cdd:COG4145 252 IGLPHTAVRCMAYkDSKSLHRAM-IIGTIVVGLLMFGMHLIGVLGRAV--------LPD---LTVPDQVIPTLMVKVLPP 319
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 247 YISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNAS--DKEIVWVMRITVFVFGASATAMALLTKTVygLWYL 324
Cdd:COG4145 320 FLAGIFLAGPLAAIMSTVDSLLLQASSTIVKDLYLNYINPKASenEKKLKRLSKLVTLVLGLIVFLLALNPPDL--IIWL 397
|
330 340 350
....*....|....*....|....*....|....*...
gi 767919123 325 SSDLVY---IVIFPQLLCVLFVKGTNTYGAVAGYVSGL 359
Cdd:COG4145 398 NLFAFGgleAAFFWPLVLGLYWKRANATGAIASMLVGV 435
|
|
| ActP |
COG4147 |
Na+(or H+)/acetate symporter ActP [Energy production and conversion]; |
66-415 |
3.10e-15 |
|
Na+(or H+)/acetate symporter ActP [Energy production and conversion];
Pssm-ID: 443318 Cd Length: 526 Bit Score: 77.89 E-value: 3.10e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 66 GATISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQ----LFCIFVG-LWISVPFALSHPAVAD--IGFTAVHA 138
Cdd:COG4147 149 GVLISLLLGVDYEVAVVIVGVLMIVYVVLGGMKGTTWVQIIKavllIFAYTVPaVLVLAQFGFNPLPLLAkaAEVHDLGA 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 139 KYQKPWLGtvdsseVYSWLDSFLL---LMLG--GIPW---------QAYFQRvlssSSATYAQVLSFLAAFGCLVMAIPA 204
Cdd:COG4147 229 AYLEPGGL------VKSPLDFISLglaLMLGtaGLPHilmrfftvpDAKEAR----KSVGWALGFIGLFYLTAPALGFGA 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 205 ILIgaIGASTDWNQTAYGLPDPKTTEEADMILPIVLQyLCPVYISFFGLGAVsAAVMSSADSSILSASSMFARNIYQLSF 284
Cdd:COG4147 299 RAL--VGPLPEWFDTGLIGAADGGGNMAVLALAEIAG-GGNWLLGLVAAGAF-ATILAVVAGLLLAIASAISHDLYANVI 374
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 285 RQNASDKEIVWVMRITVFVFGASATAMALLTKT--VYGLWYLSSDLVYIVIFPQLLCVLFVKGTNTYGAVAGYVSGLFLR 362
Cdd:COG4147 375 KGKATEKEELRVARIAAVVIGVVAILLGINAPPqnVAFLVALAFALAASANFPVLLLSIFWKRFNTRGAVAGMLVGLISA 454
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 767919123 363 ITggepYLYLQPLIFYPGYypdDNGIynqkFPFK---TLAMVTSFLTNICISYLAK 415
Cdd:COG4147 455 LV----LIVLSPFVWVLGV---DAAL----FPLEnpgLVSMPLGFLVAIVVSLLTP 499
|
|
| SLC5sbd_NIS-like |
cd10326 |
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ... |
41-376 |
2.49e-13 |
|
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and 2. SMCT1(the product of the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (product of the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271361 [Multi-domain] Cd Length: 472 Bit Score: 71.82 E-value: 2.49e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 41 RMGGLLFIPALMGEMFwaaaIFSALGATISVIidvdmhisVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVP 120
Cdd:cd10326 126 GAGIRLYLVALVLQQF----LFDSLGIPFWLT--------VLITGLLIWLYTFRGGIKTVVWTDTLQTVFLLVGLVLTII 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 121 FALSHpavADIGF-TAVHAKYQKPWLGTVDSSEVYSWLdSFLLLMLGGIPW--------QAYFQRVLSSSSATYAQVLSF 191
Cdd:cd10326 194 IISNS---LGLGFgEAISAAGESGYSRIFNFDDDNSRR-TFWKQFLGGIFItiamtgldQDMMQRNLSCKNLKDAQKNML 269
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 192 LAAFGCLVMaipAILIGAIGASTDWNQTAYGLPDPKttEEADMILP-IVLQYLCPVYISFFGLGAVSAAvMSSADSSILS 270
Cdd:cd10326 270 TFGVILVPV---NLLFLLLGVLLYTYAQKNGIALPA--KDSDQLFPyFALNGLPPGVSGLFVAGIIAAA-MSSADSALTA 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 271 ASSMFARNIYQLSFRQN--ASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWYLSSDLVYIVIFPQLLCVLFVKGTNT 348
Cdd:cd10326 344 LTTSFCVDILNRFKRKSekKSERKYVHIAFSLTFVLGILVFGSASNSGSLIDAIFKVAGYTYGPLLGLFAFGLFTKRAVK 423
|
330 340 350
....*....|....*....|....*....|....*..
gi 767919123 349 --YGAVAG-------YVSGLFLRITGGEPYLYLQPLI 376
Cdd:cd10326 424 dkWVPLVGllapvlsYLLVSNSEGFFGYKFGFELLII 460
|
|
| SLC5sbd_SGLT2 |
cd11487 |
Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 ... |
15-361 |
5.52e-12 |
|
Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 (hSGLT2) is a high-capacity, low-affinity glucose transporter, that plays an important role in renal glucose reabsorption. It is encoded by the SLC5A2 gene and expressed almost exclusively in renal proximal tubule cells. Mutations in hSGLT2 cause Familial Renal Glucosuria (FRG), a rare autosomal defect in glucose transport. hSGLT2 is a major drug target for regulating blood glucose levels in diabetes. hSGLT2 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 212056 [Multi-domain] Cd Length: 583 Bit Score: 68.02 E-value: 5.52e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 15 GLFFAKPMRSKGYVTMLDPFQQIYG-KRMGGLLFIPALMGEMFWAAAIFSALGAT-ISVIIDVDMHISVIISALIATLYT 92
Cdd:cd11487 87 GWLFVPVYLTAGVITMPQYLKKRFGgQRIRLYLSVLSLFLYIFTKISVDMFSGAVfIQQALGWNIYASVIALLGITMIYT 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 93 LVGGLYSVAYTDVVQLFCIFVGLWISVPFALSHPAvadiGFTAVHAKYQK----------PWLGTVDSSEVYSWLDSFLL 162
Cdd:cd11487 167 VTGGLAALMYTDTVQTFVIIGGACVLMGYAFHEVG----GYSALFEKYLKavpsltvsedPAVGNISSSCYRPRPDSYHL 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 163 L---MLGGIPW------------------QAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNQTAY 221
Cdd:cd11487 243 LrdpVTGDLPWpalilgltivsswywcsdQVIVQRCLAARSLTHVKAGCILCGYLKLLPMFLMVMPGMISRVLYPDEVAC 322
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 222 GLPDPKT----TEE--ADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQlSFRQNASDKEIVW 295
Cdd:cd11487 323 VEPSVCLrvcgTEVgcSNIAYPKLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIWT-RLRPQAGDKELLL 401
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767919123 296 VMRI-TVFVFGASATAMALLTKTVYGLWYLSSDLVYIVIFPQLLCV----LFVKGTNTYGAVAGYVSGLFL 361
Cdd:cd11487 402 VGRVwVVCIVAVSVAWIPVVQAAQGGQLFDYIQSVSSYLAPPIAAVfflaLFVKRVNEPGAFWGLIGGLLM 472
|
|
| SLC5sbd_SGLT1 |
cd11486 |
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a ... |
26-363 |
9.94e-12 |
|
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a high-affinity/low-capacity glucose transporter, which can also transport galactose. In the transport mechanism, two Na+ ions first bind to the extracellular side of the transporter and induce a conformational change in the glucose binding site. This results in an increased affinity for glucose. A second conformational change in the transporter follows, bringing the Na+ and glucose binding sites to the inner surface of the membrane. Glucose is then released, followed by the Na+ ions. In the process, hSGLT1 is also able to transport water and urea and may be a major pathway for transport of these across the intestinal brush-border membrane. hSGLT1 is encoded by the SLC5A1 gene and expressed mostly in the intestine, but also in the trachea, kidney, heart, brain, testis, and prostate. The WHO/UNICEF oral rehydration solution (ORS) for the treatment of secretory diarrhea contains salt and glucose. The glucose, along with sodium ions, is transported by hSGLT1 and water is either co-transported along with these or follows by osmosis. Mutations in SGLT1 are associated with intestinal glucose galactose malabsorption (GGM). Up-regulation of intestinal SGLT1 may protect against enteric infections. SGLT1 is expressed in colorectal, head and neck, and prostate tumors. Epidermal growth factor receptor (EGFR) functions in cell survival by stabilizing SGLT1, and thereby maintaining intracellular glucose levels. SGLT1 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5)transporter family.
Pssm-ID: 271379 Cd Length: 636 Bit Score: 67.27 E-value: 9.94e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 26 GYVTMLDPFQQIYG-KRMGGLLFIPALMGEMFW--AAAIFSalGAT-ISVIIDVDMHISVIISALIATLYTLVGGLYSVA 101
Cdd:cd11486 98 GVVTMPEYLRKRFGgQRIQVYLSVLSLCLYIFTkiSADIFS--GAIfINLALGLNLYLAIVILLAITALYTITGGLAAVI 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 102 YTDVVQLFCIFVGLWISVPFALSHPAvadiGFTAVHAKYQK--PWLGTVDSSEVYSWL-----DSFLLL---MLGGIPW- 170
Cdd:cd11486 176 YTDTLQTIIMVVGSFILMGFAFNEVG----GYDAFMEKYMTaiPSVIGTGNSTSQEKCytpraDSFHIFrdpITGDLPWp 251
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 171 -----------------QAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNQTAYGLPDP------K 227
Cdd:cd11486 252 gllfglsiltlwywctdQVIVQRCLSAKNMSHVKAGCILCGYLKLLPMFIMVMPGMISRILYTDEIACVVPDEckavcgT 331
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 228 TTEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQlSFRQNASDKEIVWVMRITVFVFGAS 307
Cdd:cd11486 332 EVGCTNIAYPKLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYT-KVRKKASEKELMIAGRLFMLVLIGI 410
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767919123 308 ATAMALLTKTVYG---LWYLSSDLVYIV--IFPQLLCVLFVKGTNTYGAVAGYVSGLFLRI 363
Cdd:cd11486 411 SIAWVPIVQSAQSgqlFDYIQSITSYLGppIAAVFLLAIFCKRVNEPGAFWGLCVGLLVGL 471
|
|
| SLC5sbd_SGLT4 |
cd11488 |
Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 ... |
15-364 |
4.40e-11 |
|
Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 (hSGLT4) has been reported to be a low-affinity glucose transporter with unusual sugar selectivity: it transports D-mannose but not galactose or 3-O-methyl-D-glucoside. It is encoded by the SLC5A9 gene and is expressed in intestine, kidney, liver, brain, lung, trachea, uterus, and pancreas. hSLGT4 is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5 )transporter family.
Pssm-ID: 271380 Cd Length: 605 Bit Score: 65.34 E-value: 4.40e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 15 GLFFAKPMRSKGYVTMLDPFQ--------QIYGKRMGGLLFIPALMGEMFWAAAIFsalgatISVIIDVDMHISVIISAL 86
Cdd:cd11488 86 GWIFVPVYIAAGVVTMPEYLKkrfggqriRIYMSVLSLILYIFTKISTDIFSGALF------IQVSLGWNLYLSTVILLA 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 87 IATLYTLVGGLYSVAYTDVVQLFCIFVGlwisvPFALSHPAVADIG-FTAVHAKYQK--PWLGTVDSSEVYSWLDSFLLL 163
Cdd:cd11488 160 VTALYTIAGGLTAVIYTDALQTVIMVIG-----AFVLMFIAFDKVGwYPGLEQQYEKaiPALTVPNTTCHLPRSDAFHIF 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 164 ---MLGGIPW------------------QAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNQTayG 222
Cdd:cd11488 235 rdpVTGDIPWpglifgltvlatwvwctdQVIVQRSLSAKNLSHAKGGSVLGGYLKILPMFFVVMPGMISRALFPDEV--G 312
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 223 LPDPKTTEE--------ADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQlSFRQNASDKEIV 294
Cdd:cd11488 313 CVDPDECQKicgakvgcSNIAYPKLVVELMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTMDVWQ-RIRRRASEQELM 391
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767919123 295 WVMRI-TVFVFGASATAMALLTKTVYGLW--YLSSDLVYIV--IFPQLLCVLFVKGTNTYGAVAGYVSGLFLRIT 364
Cdd:cd11488 392 VVGRVfILLLVVISILWIPIIQTANSGQLfdYIQAVTSYLSppITAVFILAIFWKRVNEPGAFWGLMVGLVVGLV 466
|
|
| SLC5sbd_PanF |
cd10327 |
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute ... |
28-359 |
6.06e-11 |
|
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; PanF catalyzes the Na+-coupled uptake of extracellular pantothenate for coenzyme A biosynthesis in cells. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 212037 Cd Length: 472 Bit Score: 64.53 E-value: 6.06e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 28 VTMLDPFQQIYGKRmgGLLFIPALMGEMFWAAAIFSAL--GAT-ISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTD 104
Cdd:cd10327 106 VTIIDYLRARYNSK--ALVVLSSLALIVFFIAAMVAQFigGARlLEAVTGLSYVTGLLIFGLTVILYTTIGGFRAVALTD 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 105 VVQLFCIFVG---LWISVPFALSHPAVADIGFTAVHAKYQKPWLGTVDSSevySWLDSF-LLLMLG--GIPWQAyfQRVL 178
Cdd:cd10327 184 AIQGIVMIIGtvlLLVGVLAAGGGMEAIMATLAEIDPNLLTPFGPGFLSP---PYILSFwVLVGFGviGLPQTA--VRCM 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 179 S---SSSATYAQVLSflaAFGCLVMAIPAILIGAIGASTdwnqtaygLPDPkttEEADMILPIVLQYLCPVYISFFGLGA 255
Cdd:cd10327 259 GykdSKSMHRAMIIG---TVVVGFLMLGMHLAGVLGRAV--------LPDL---EVPDKVIPTLALKVLPPWLAGLFLAG 324
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 256 VSAAVMSSADSSILSASSMFARNIYQLSFR--QNASDKEIVWVMRITVFVFGASATAMALLTKTVyglwylssdLVYIVI 333
Cdd:cd10327 325 PLAAIMSTVDSQLILASSAIVKDLYLNYKNkeKKTSEKKVKRISLIITIILGLLVFLLAINPPDL---------IVWLNL 395
|
330 340 350
....*....|....*....|....*....|....*.
gi 767919123 334 FP----------QLLCVLFVKGTNTYGAVAGYVSGL 359
Cdd:cd10327 396 FAfggleaaffwPLVLGLYWKRANATGALASMVVGL 431
|
|
| SLC5sbd_SGLT6 |
cd11490 |
Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human ... |
57-447 |
2.63e-10 |
|
Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human SGLT6 (also called KST1, SMIT2) is a chiro-inositol transporter, which also transports myo-inositol. It is encoded by the SLC5A11 gene. Xenopus Na1-glucose cotransporter type 1 (SGLT-1)-like protein is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271381 Cd Length: 602 Bit Score: 62.62 E-value: 2.63e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 57 WAAAIFsalgatISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFALSHPAvadiGFTAV 136
Cdd:cd11490 136 YAGAVF------IQQALQWDLYLAVVGLLGITALYTVAGGLAAVIYTDALQTIIMVIGALILMGYSFAEVG----GFEAL 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 137 HAKYQK--PWLGTVDSSEVYSWLDSFLLL---MLGGIPW------------------QAYFQRVLSSSSATYAQVLSFLA 193
Cdd:cd11490 206 LEKYFQaiPSIRSPNSTCGIPREDAFHIFrdpVTSDLPWpgvllgmsipslwywctdQVIVQRSLAAKNLSHAKGGSLLA 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 194 AFGCLVMAIPAILIGAIGASTDWNQTAYGlpDPKTTEE--------ADMILPIVLQYLCPVYISFFGLGAVSAAVMSSAD 265
Cdd:cd11490 286 AYLKVLPLFMMVIPGMISRILFPDQVACA--DPEVCKEicgnpsgcSDIAYPKLVMELLPTGLRGLMMAVMLAALMSSLT 363
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 266 SSILSASSMFARNIYQlSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYG---LWYLSSDLVYI-----VIFpql 337
Cdd:cd11490 364 SIFNSASTIFTMDLWR-HIRPRASEWELMIVGRVFVLVLVVVSILWIPLVQASQGgqlFIYIQSISSYLqppvaVVF--- 439
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 338 LCVLFVKGTNTYGAVAGYVSGLFLRITGGE-PYLYLQPLIfypgYYPDDNGIYNQKFPFKTLAMVTSFLTNICISYLAKY 416
Cdd:cd11490 440 IAGCFWKRTNEKGAFWGLMVGLAVGLTRMVlDFIYVTPQC----DQPDTRPDIVKYVHYLYFSMILTILTLVVVVCVSLA 515
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 767919123 417 lfesgTLPPKLDV---------FDAVVarhSEENMDKTIL 447
Cdd:cd11490 516 -----TEPPSKEMisrltwftrFDAVV---ESEELKKAIL 547
|
|
| SLC5sbd_SGLT5 |
cd11489 |
Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is ... |
24-364 |
7.09e-10 |
|
Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is a glucose transporter, which also transports galactose. It is encoded by the SLC5A10 gene, and is exclusively expressed in the renal cortex. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 212058 Cd Length: 604 Bit Score: 61.49 E-value: 7.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 24 SKGYVTMLDPFQQIYG-KRMGGLLFIPALMGEMFWAAAIFSALGAT-ISVIIDVDMHISVIISALIATLYTLVGGLYSVA 101
Cdd:cd11489 98 SSGIVTMPEYLQRRFGgERIRMYLSVLSLLLSVFTKISTDLYSGALfVQVCLGWNLYLSTVLMLVVTALYTIAGGLAAVI 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 102 YTDVVQLFCIFVGLWIsvpfaLSHPAVADIGFtavHAKYQKPWLGTVDSSEV---------YSWLDSFLLLMLGGIPW-- 170
Cdd:cd11489 178 YTDALQTLIMVIGAVI-----LTIKAFNQIGG---YSNLEEAYLQAVPSKIIpnttchlprADAMHLFRDPVTGDLPWtg 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 171 ----------------QAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIgaSTDWNQTAYGLPDPKTTEEA-- 232
Cdd:cd11489 250 mtfgltimatwywctdQVIVQRSLSARSLSHAKGGSILASYLKMLPMGLIIMPGMI--SRALFPDDVACVDPEECLRVcg 327
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 233 ------DMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQlSFRQNASDKEIVWVMRI-TVFVFG 305
Cdd:cd11489 328 aevgcsNIAYPKLVMELMPSGLRGLMIAVMMAALMSSLTSIFNSSSTLFTMDIWR-RLRPGASERELLLVGRLvTVILVG 406
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767919123 306 ASATAMALLTKTVYGLWYLSSDLVYIVIFPQLLCV----LFVKGTNTYGAVAGYVSGLFLRIT 364
Cdd:cd11489 407 VSVVWIPILQSSNSGQLYIYIQSVTSYLAPPVTAVfvlaVFWRRANEQGAFWGLMAGLVVGLT 469
|
|
| SLC5sbd_NIS-like_u1 |
cd11493 |
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
69-314 |
3.12e-09 |
|
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271384 [Multi-domain] Cd Length: 479 Bit Score: 59.15 E-value: 3.12e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 69 ISVIIDVD-----MHISVIISALIATLYTLVGGLYSVAYTDVVQlFCIFVGLWISVPFALSHPAVADIGFTAVHAkyQKP 143
Cdd:cd11493 138 VSMILGADgvalsYIASILIISVVTLLYTYFGGIRAVVWTDVIQ-LVVYIGGAVAALAYLLGALPADWLQIAAAA--GKF 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 144 WLGTVDS-----SEVYSwldsFLLLMLGGIPW--------QAYFQRVLSSSSATYAQvlsfLAAFGCLVMAIP-AILIGA 209
Cdd:cd11493 215 HLFDLSDlilglTSPYT----FWAAIIGGALLsmashgtdQLMVQRLLACRNLRDAQ----KALIGSGVVVFPqFALFLL 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 210 IGASTdWnqTAYGLPDP--KTTEEADMILP-IVLQYLcPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQ 286
Cdd:cd11493 287 IGLLL-Y--VYYGGASLaaLGLGSPDEVFPyFIVHEL-PAGLRGLLIAGILAAAMSTLSSALNSLASSTVQDLYQPWKRR 362
|
250 260
....*....|....*....|....*...
gi 767919123 287 NASDKEIVWVMRITVFVFGASATAMALL 314
Cdd:cd11493 363 RLSDEKLLRASRLLTLVWAVVLVGIALL 390
|
|
| SLC5sbd_NIS-SMVT |
cd11492 |
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ... |
68-380 |
6.73e-09 |
|
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (encoded by the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (encoded by the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and -2. SMCT1(encoded by the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (encoded by the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271383 [Multi-domain] Cd Length: 522 Bit Score: 58.27 E-value: 6.73e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 68 TISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFALSHPavadIGFTAVhakyqkpWLGT 147
Cdd:cd11492 141 ALSQVTGINLHIIILVVGIVCIFYTTLGGLKAVVWTDVFQVVVMFGGVLAVIILGTIDV----GGFSEV-------WEIA 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 148 VDSSEVYSW---LD-----SFLLLMLGG-IPW-------QAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIG 211
Cdd:cd11492 210 EEGGRLEFFnfdPDptvrhTFWSLVIGGtFTWlslygvnQTQVQRYLSLPSLKSAKKALWLNIVGLILILSLCCFTGLVI 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 212 ASTDWNqtayglPDPKTT---EEADMILP-IVLQYLcPVYISFFGL---GAVSAAvMSSADSSILSASSMFARNIYQLSF 284
Cdd:cd11492 290 YAKYHD------CDPLTAgliKKPDQLLPyFVMDVL-GHLPGLPGLfvaGIFSAA-LSTLSSGLNSLAAVILEDFIKPFF 361
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 285 RQNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWYLSSDLVYIVIFPqLLCV----LFVKGTNTYGAVAGYVSGLF 360
Cdd:cd11492 362 KKKLSERQATNIMKLLVVVFGLLCIGLAFLVEKLGGVLQLSLSIFGITGGP-LLGIftlgMFFPWANSKGALVGLLVGLI 440
|
330 340
....*....|....*....|..
gi 767919123 361 --LRITGGEPYLYLQPLIFYPG 380
Cdd:cd11492 441 fmLWIGIGGQIAIAPGPLSFPP 462
|
|
| SLC5sbd_YidK |
cd10328 |
uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; ... |
79-361 |
4.62e-08 |
|
uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Uncharacterized subfamily of the solute binding domain of the solute carrier 5 (SLC5) transporter family (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily includes the uncharacterized Escherichia coli YidK protein, and belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271362 Cd Length: 472 Bit Score: 55.23 E-value: 4.62e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 79 ISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGlWISVPF----ALSHPAVADIGFTAVHAKYQK-PWLGTVDSSEV 153
Cdd:cd10328 157 LLVWLIGIIGAIYAIFGGLKAVAVSDTINGVGLLIG-GLLIPIlgliALGDGSFLAGLDTLLTAHPEKlNAIGGADSPVP 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 154 YSWLdsFLLLMLGGI-PW---QAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIgastdwnqtAYGLPdPKTT 229
Cdd:cd10328 236 FSTL--FTGMLLVNLfYWctnQAIIQRALAAKNLKEGQKGVLLAGFFKLLVPLILVLPGII---------AFHLY-GDGL 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 230 EEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASAT 309
Cdd:cd10328 304 ENADMAYPTLVADVLPKWLSGFFAAVLFGAILSSFNSALNSAATLFSLDIYKPIINKNATDKQLVKVGKIFGIVLALISM 383
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 767919123 310 AMA-LLTKTVYGLWYL---SSDLVYIVIFPQLLCVLFVKGTNTYGAVAGYVSGLFL 361
Cdd:cd10328 384 IIApFIAYAPEGLFNYlqqFNGFFSIPILAIVLVGFFTKRVPALAAKIALIFGVIL 439
|
|
| PRK15419 |
PRK15419 |
sodium/proline symporter PutP; |
85-312 |
3.69e-07 |
|
sodium/proline symporter PutP;
Pssm-ID: 185317 Cd Length: 502 Bit Score: 52.71 E-value: 3.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 85 ALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFALshpaVADIGFTAVHAKYQKPWLGTVDSSEVYSWLdSFLLLM 164
Cdd:PRK15419 168 AAATILYTFIGGFLAVSWTDTVQASLMIFALILTPVIVI----ISVGGFGDSLEVIKQKSIENVDMLKGLNFV-AIISLM 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 165 LGGIPW------QAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNQTAyglpdpKTTEEADMILPI 238
Cdd:PRK15419 243 GWGLGYfgqphiLARFMAADSHHSIVHARRISMTWMILCLAGAVAVGFFGIAYFNEHPAVAG------AVNQNAERVFIE 316
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767919123 239 VLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMA 312
Cdd:PRK15419 317 LAQILFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKHASQKELVWVGRVMVLVVALVAIALA 390
|
|
| PRK10484 |
PRK10484 |
putative transporter; Provisional |
79-365 |
3.76e-07 |
|
putative transporter; Provisional
Pssm-ID: 236699 [Multi-domain] Cd Length: 523 Bit Score: 52.58 E-value: 3.76e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 79 ISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFALShpAVADIGF-------TAVHA-KYQKpwLGTVDS 150
Cdd:PRK10484 163 LLVWLIGIIGAIYAVFGGLKAVAVSDTINGIGLLIGGLLVPVFGLI--ALGDGSFmqgleqlTTVHPeKLNS--IGGATD 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 151 SevYSWLDSFLLLMLGGI-PW---QAYFQRVLSSSSATYAQ----VLSFLAAFGCLVMAIPAILigaigastdwnqtAYG 222
Cdd:PRK10484 239 P--VPFPTLFTGLILVNLfYWctnQSIVQRALGAKNLAEGQkgalLAAFFKLLGPLILVLPGII-------------AFH 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 223 LPdPKTTEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVF 302
Cdd:PRK10484 304 LY-GDGLPNADMAYPTLVNDVLPVPLVGFFAAVLFGAILSTFNGFLNSASTLFSLDIYKPIINPNASEKQLVKVGKKFGF 382
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767919123 303 VFGASATAMA-LLTKTVYGLWYLSSDLVYIVIFPQLLCVL---FVKGTNTYGAVAGYVSGLFLRITG 365
Cdd:PRK10484 383 VLAIISMIVApLIANAPQGLYSYLQQLNGIYNVPILAIIIvgfFTKRVPALAAKVALGFGIILYIII 449
|
|
| SLC5sbd_SMIT |
cd11491 |
Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT ... |
76-361 |
1.31e-06 |
|
Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT is a high-affinity myo-inositol transporter, and is expressed in brain, heart, kidney, and lung. Inhibition of myo-inositol uptake, through down-regulation of SMIT, may be a common mechanism of action of mood stabilizers, including lithium, carbamazepine, and valproate. SMIT is encoded by the SLC5A3 gene, which is a candidate gene for pathogenesis of nervous system dysfunction in Down syndrome (DS). The SNP, 21q22 near SLC5A3-MRPS6-KCNE2, has been associated with coronary heart disease, cardiovascular disease, and myocardial infarction. SMIT may also be involved in the pathogeneisis of congenital cataract. SMIT also plays roles in osteogenesis, bone formation, and bone mineral density determination. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271382 Cd Length: 609 Bit Score: 51.02 E-value: 1.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 76 DMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFALSHPAvadiGFTAVHAKYQKPWLGTVDSSEVYS 155
Cdd:cd11491 149 NLYVSIILLLGLTALLTVTGGLAAVIYTDTLQAFLMIIGALTLMIISMMEIG----GFEGVKSRYMLASPNVTSILLTYN 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 156 WL-----------DSFLLL---MLGGIPW------------------QAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIP 203
Cdd:cd11491 225 LSntnsccvhpkkDAFKLLrdpTDEDVPWpgfilgqtpasiwywcadQVIVQRVLAAKSLSHAQGATLMAGFIKLLPLFI 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 204 AILIGAIGASTDWNQTAYGLPDP------KTTEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFAR 277
Cdd:cd11491 305 IVIPGMISRILFPDDIACINPEHcmqvcgSRAGCSNIAYPRLVMKIMPSGLRGLMMAVMIAALMSDLTSIFNSASTLFTL 384
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 278 NIYQLsFRQNASDKEIVWVMRITV-FVFGASATAMALLTKTVYGLWYLSSDLVYIVIFPQL----LCVLFVKGTNTYGAV 352
Cdd:cd11491 385 DVYKL-IRKKASSRELMIVGRIFVaVMVVISIAWIPVIQEMQGGQLYLYIQEVAAYLTPPVaslyLLAIFWKRTTEQGAF 463
|
....*....
gi 767919123 353 AGYVSGLFL 361
Cdd:cd11491 464 YGGMAGFVL 472
|
|
| SLC5sbd_SMVT |
cd11504 |
Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain; This ... |
16-361 |
3.02e-06 |
|
Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain; This multivitamin transporter SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate, and is essential for mediating biotin uptake into mammalian cells. SMVT is expressed in the placenta, intestine, heart, brain, lung, liver, kidney and pancreas. Biotin may regulate its own cellular uptake through participation in holocarboxylase synthetase-dependent chromatin remodeling events at SMVT promoter loci. The cis regulatory elements, Kruppel-like factor 4 and activator protein-2, regulate the activity of the human SMVT promoter in the intestine. Glycosylation of the hSMVT is important for its transport function. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271394 [Multi-domain] Cd Length: 527 Bit Score: 49.88 E-value: 3.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 16 LFFAKPMRSKGYVTMLdpFQQIYgkRMGGLLFIPALmgemfwaaaifsalgaTISVIIDVDMHISVIISALIATLYTLVG 95
Cdd:cd11504 112 LRFNKTVRICGTVTFI--FQMVI--YMGVVLYAPAL----------------ALNAVTGFNLWISVLAMGVVCTFYTALG 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 96 GLYSVAYTDVVQLFCIFVG-LWISVPFALSHPAVADIGFTAVHAKYQKPWLGTVDSSEVYS-WL----DSFLLLMLGGIP 169
Cdd:cd11504 172 GLKAVIWTDVFQTVVMFAGqLAVIIVGSIEAGGIARVWRVAAESDRIDGFNLSPDPTIRHTfWTlvvgGVFNMLALYGVN 251
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 170 wQAYFQRVLSSSSATYAqVLSFLAAFGCLVMAIPAI-LIGAIGASTdwnqtaYGLPDPKTTEEADMILPIVLQYLCPVYI 248
Cdd:cd11504 252 -QAQVQRYLSSRTEKQA-KRSCYLVFPGQQLSLCIGcLCGLVMFAR------YHECDPLKNGIVARSDQLVPYFVMDVLD 323
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 249 SFFGL-GAVSAAVMSSADSSILSASSMFA----RNIYQLSFRqNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWY 323
Cdd:cd11504 324 GLPGLpGLFIACLFSGALSTISSAFNSLAtvtmEDLIVPKFP-DMTEERATLLSKGLAVGYGLLCLLMAYLASTMGQVLQ 402
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 767919123 324 LSSDLVYIVIFP--QLLCV-LFVKGTNTYGAVAGYVSGLFL 361
Cdd:cd11504 403 AANSIFGMIGGPllGLFCLgMFFPCANSAGAVVGLLAGLFM 443
|
|
| PRK12488 |
PRK12488 |
cation/acetate symporter; |
66-360 |
7.21e-04 |
|
cation/acetate symporter;
Pssm-ID: 237114 [Multi-domain] Cd Length: 549 Bit Score: 42.09 E-value: 7.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 66 GATISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFALSH----PAVADIGFTAVHAKYQ 141
Cdd:PRK12488 169 GKLIELLFGISYLYAVVIVGALMVLYVTFGGMLATTWVQIIKAVLLLSGTSFMAFMVLKHfgfsTEAMFASAVAVHAKGQ 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 142 KPWLGTVDSSEVYSWLDSFLLLMLGGIPWQAYFQRVLSSSSATYAQVlSFLAAFG--------CLVMAIPAILIgaIGAs 213
Cdd:PRK12488 249 AILAPGGLLSNPIDAISLGLGMMFGTAGLPHILMRFFTVSDAREARK-SVLYATGfigyfyllIIVVGFGAIVM--VGT- 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919123 214 tdwnQTAYGLPDPKTTEEADMilpiVLQYLCPVYISFFGLGAVSAAVMSSADSSI----LSASSMFARNIYQLSFRQ-NA 288
Cdd:PRK12488 325 ----EPSYRDAGGKIIGGGNM----VAVHLAQAVGGNLFLGFISAVAFATILAVVaglaLSGASAVSHDLYACVIRKgQA 396
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767919123 289 SDKEIVWVMRITVFVFGASATAMALL--TKTVYGLWYLSSDLVYIVIFPQLLCVLFVKGTNTYGAVAGYVSGLF 360
Cdd:PRK12488 397 SEAQEMRVSKIATLGIGLLAVVLGLMfeSQNIAFLSGLVLAIAASVNFPVLFLSMFWKGLTTRGAVAGSYAGLV 470
|
|
| SLC5sbd_NIS |
cd11503 |
Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of ... |
51-117 |
1.01e-03 |
|
Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. NIS is expressed in the thyroid, colon, ovary, and in human breast cancers. It mediates the active transport and the concentration of iodide from the blood into thyroid follicular cells, a fundamental step in thyroid hormone biosynthesis, and is the basis of radioiodine therapy for thyroid cancer. Mutation in the SLC5A5 gene can result in a form of thyroid hormone dysgenesis. Human NIS exists mainly as a dimer stabilized by a disulfide bridge. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271393 Cd Length: 535 Bit Score: 41.75 E-value: 1.01e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767919123 51 LMGEMFWAAAIFSALGATISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWI 117
Cdd:cd11503 124 IVATMLYTGIVIYAPALILNQVTGLDIWASLFSTGIICTFYTTVGGMKAVIWTDVFQVVVMLSGFWA 190
|
|
| |
