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Conserved domains on  [gi|767919364|ref|XP_011509980|]
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aquaporin-12B isoform X12 [Homo sapiens]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 239)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  8849412|11473620|11964478
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIP super family cl00200
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 89-242 2.55e-04

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


The actual alignment was detected with superfamily member cd00333:

Pssm-ID: 444743  Cd Length: 228  Bit Score: 41.09  E-value: 2.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919364  89 GASANPTVSLQEFLMAEESLPGTLLKLAAQGLGMQAACTLTRLCWA---WELSDLHLLQSLMAQSCSSALRTSVpHGALV 165
Cdd:cd00333   57 GGHINPAVTLALAVGGRFPLIRVIPYIIAQLLGAILGAALLYGLYYglyLEFLGANNIVAGIFGTYPSPGVSNG-NAFFV 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919364 166 EAACAFCFHLTLLHL-----RHSPPAYSGPAVALLVTVTAYTAGPFTSAFFNPALAASVTFACSGHTLLEYVQVYWLGPL 240
Cdd:cd00333  136 EFIGTFILVLVVFATtddpnGPPPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLARHWHYFWVYWVGPL 215


                 ..
gi 767919364 241 TG 242
Cdd:cd00333  216 IG 217
 
Name Accession Description Interval E-value
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 89-242 2.55e-04

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 41.09  E-value: 2.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919364  89 GASANPTVSLQEFLMAEESLPGTLLKLAAQGLGMQAACTLTRLCWA---WELSDLHLLQSLMAQSCSSALRTSVpHGALV 165
Cdd:cd00333   57 GGHINPAVTLALAVGGRFPLIRVIPYIIAQLLGAILGAALLYGLYYglyLEFLGANNIVAGIFGTYPSPGVSNG-NAFFV 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919364 166 EAACAFCFHLTLLHL-----RHSPPAYSGPAVALLVTVTAYTAGPFTSAFFNPALAASVTFACSGHTLLEYVQVYWLGPL 240
Cdd:cd00333  136 EFIGTFILVLVVFATtddpnGPPPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLARHWHYFWVYWVGPL 215


                 ..
gi 767919364 241 TG 242
Cdd:cd00333  216 IG 217
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 152-242 4.22e-04

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 40.50  E-value: 4.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919364 152 SSALRTSVPHGALVEAACAFCFHLTLLHL---RHSPPAYSGPAVALLVTVTAYTAGPFTSAFFNPA--LA-ASVTFACSG 225
Cdd:COG0580  123 SPAIGYSLGAAFLTEIIGTFVLVFVILGItdkRAAPGGLAPLAIGLLVAAIGLSLGPLTGYAINPArdLGpRLFHALGKG 202

                         90
                 ....*....|....*..
gi 767919364 226 HTLLEYVQVYWLGPLTG 242
Cdd:COG0580  203 GSDWGYLWVPIVAPILG 219
 
Name Accession Description Interval E-value
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 89-242 2.55e-04

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 41.09  E-value: 2.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919364  89 GASANPTVSLQEFLMAEESLPGTLLKLAAQGLGMQAACTLTRLCWA---WELSDLHLLQSLMAQSCSSALRTSVpHGALV 165
Cdd:cd00333   57 GGHINPAVTLALAVGGRFPLIRVIPYIIAQLLGAILGAALLYGLYYglyLEFLGANNIVAGIFGTYPSPGVSNG-NAFFV 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919364 166 EAACAFCFHLTLLHL-----RHSPPAYSGPAVALLVTVTAYTAGPFTSAFFNPALAASVTFACSGHTLLEYVQVYWLGPL 240
Cdd:cd00333  136 EFIGTFILVLVVFATtddpnGPPPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLARHWHYFWVYWVGPL 215


                 ..
gi 767919364 241 TG 242
Cdd:cd00333  216 IG 217
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 152-242 4.22e-04

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 40.50  E-value: 4.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919364 152 SSALRTSVPHGALVEAACAFCFHLTLLHL---RHSPPAYSGPAVALLVTVTAYTAGPFTSAFFNPA--LA-ASVTFACSG 225
Cdd:COG0580  123 SPAIGYSLGAAFLTEIIGTFVLVFVILGItdkRAAPGGLAPLAIGLLVAAIGLSLGPLTGYAINPArdLGpRLFHALGKG 202

                         90
                 ....*....|....*..
gi 767919364 226 HTLLEYVQVYWLGPLTG 242
Cdd:COG0580  203 GSDWGYLWVPIVAPILG 219
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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