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Conserved domains on  [gi|767919419|ref|XP_011510000|]
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secreted phosphoprotein 24 isoform X1 [Homo sapiens]

Protein Classification

Spp-24 domain-containing protein( domain architecture ID 10538481)

Spp-24 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Spp-24 pfam07448
Secreted phosphoprotein 24 (Spp-24) cystatin-like domain; This family represents a conserved ...
 73-134 1.59e-38

Secreted phosphoprotein 24 (Spp-24) cystatin-like domain; This family represents a conserved region approximately 60 residues long within secreted phosphoprotein 24 (Spp-24), which seems to be restricted to vertebrates. This is a non-collagenous protein found in bone that is related in sequence to the cystatin family of thiol protease inhibitors. This suggests that Spp-24 could function to modulate the thiol protease activities known to be involved in bone turnover. It is also possible that the intact form of Spp-24 found in bone could be a precursor to a biologically active peptide that coordinates an aspect of bone turnover.


:

Pssm-ID: 429466  Cd Length: 64  Bit Score: 127.24  E-value: 1.59e-38
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767919419   73 VLDENNLVMNLEFSIRETTCRKDSGEDPATCAFQRDYYVSTAVCRSTVKVSAQQVQGVHARC 134
Cdd:pfam07448   1 VLDEDSLSMDLEFSIRETTCRRDSGEDPSTCDFQRGYYVPAAVCRSTVQMSAEQVQDVWVRC 62
 
Name Accession Description Interval E-value
Spp-24 pfam07448
Secreted phosphoprotein 24 (Spp-24) cystatin-like domain; This family represents a conserved ...
 73-134 1.59e-38

Secreted phosphoprotein 24 (Spp-24) cystatin-like domain; This family represents a conserved region approximately 60 residues long within secreted phosphoprotein 24 (Spp-24), which seems to be restricted to vertebrates. This is a non-collagenous protein found in bone that is related in sequence to the cystatin family of thiol protease inhibitors. This suggests that Spp-24 could function to modulate the thiol protease activities known to be involved in bone turnover. It is also possible that the intact form of Spp-24 found in bone could be a precursor to a biologically active peptide that coordinates an aspect of bone turnover.


Pssm-ID: 429466  Cd Length: 64  Bit Score: 127.24  E-value: 1.59e-38
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767919419   73 VLDENNLVMNLEFSIRETTCRKDSGEDPATCAFQRDYYVSTAVCRSTVKVSAQQVQGVHARC 134
Cdd:pfam07448   1 VLDEDSLSMDLEFSIRETTCRRDSGEDPSTCDFQRGYYVPAAVCRSTVQMSAEQVQDVWVRC 62
 
Name Accession Description Interval E-value
Spp-24 pfam07448
Secreted phosphoprotein 24 (Spp-24) cystatin-like domain; This family represents a conserved ...
 73-134 1.59e-38

Secreted phosphoprotein 24 (Spp-24) cystatin-like domain; This family represents a conserved region approximately 60 residues long within secreted phosphoprotein 24 (Spp-24), which seems to be restricted to vertebrates. This is a non-collagenous protein found in bone that is related in sequence to the cystatin family of thiol protease inhibitors. This suggests that Spp-24 could function to modulate the thiol protease activities known to be involved in bone turnover. It is also possible that the intact form of Spp-24 found in bone could be a precursor to a biologically active peptide that coordinates an aspect of bone turnover.


Pssm-ID: 429466  Cd Length: 64  Bit Score: 127.24  E-value: 1.59e-38
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767919419   73 VLDENNLVMNLEFSIRETTCRKDSGEDPATCAFQRDYYVSTAVCRSTVKVSAQQVQGVHARC 134
Cdd:pfam07448   1 VLDEDSLSMDLEFSIRETTCRRDSGEDPSTCDFQRGYYVPAAVCRSTVQMSAEQVQDVWVRC 62
Cathelicidins pfam00666
Cathelicidin; A novel protein family, showing a conserved proregion and a variable ...
 39-120 1.45e-03

Cathelicidin; A novel protein family, showing a conserved proregion and a variable carboxyl-terminal antimicrobial domain. This region shows similarity to cystatins.


Pssm-ID: 395539  Cd Length: 101  Bit Score: 36.71  E-value: 1.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919419   39 SLRDALSASVVKVNSQSLSPYLFRAFrsSLKRVEVLDEN-NLVMNLEFSIRETTCRKDSGEDPATCAFQRDYYVStaVCR 117
Cdd:pfam00666   4 SYREAVLRAVDQFNEQSSEANLYRLL--ELDPPPQDDEDpDTPKPVSFRVKETVCPRTTQQPPEQCDFKENGLVK--RCV 79


                  ...
gi 767919419  118 STV 120
Cdd:pfam00666  80 GTV 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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