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Conserved domains on  [gi|767920176|ref|XP_011510309|]
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major facilitator superfamily domain-containing protein 9 isoform X3 [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 13-320 3.80e-101

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17390:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 350  Bit Score: 301.45  E-value: 3.80e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  13 ALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEDGFYLTAFICFLVFILNAGLVWFFPwreakpgstekglp 92
Cdd:cd17390  106 AYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDGGFYYVALLCSAIFILNAGLVWFLL-------------- 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  93 lrkthvllgrshdtvqeaatsrraraskktaqpwvevvlalrnmknllfSEMWDIFLVRLLMAMAVMLYYSNFVLALEER 172
Cdd:cd17390  172 -------------------------------------------------SKLWDLLLVRFLMGFSVLLFRSNFSLYLEER 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176 173 FGVRPKVTGYLISYSSMLGAVAGLALGPILRLYKHNSQALLLHSSILTCTLLLLYSLAPTMGAVVLSSTLLSFSTAIGRT 252
Cdd:cd17390  203 FDLSPKTIGYLISYSGVLGALSGFLVGRILKLYKNNEYLLLLHSFILLALSLLGLALAPSIWLLVLCLTPLSISSAVLRT 282

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767920176 253 CITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGVAQEVSPCGPPSLGAVLALVAIFIMSLNKR 320
Cdd:cd17390  283 CSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLLQEFSVSGPGLLGAVLALAAILLMLARQR 350
 
Name Accession Description Interval E-value
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 13-320 3.80e-101

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 301.45  E-value: 3.80e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  13 ALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEDGFYLTAFICFLVFILNAGLVWFFPwreakpgstekglp 92
Cdd:cd17390  106 AYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDGGFYYVALLCSAIFILNAGLVWFLL-------------- 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  93 lrkthvllgrshdtvqeaatsrraraskktaqpwvevvlalrnmknllfSEMWDIFLVRLLMAMAVMLYYSNFVLALEER 172
Cdd:cd17390  172 -------------------------------------------------SKLWDLLLVRFLMGFSVLLFRSNFSLYLEER 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176 173 FGVRPKVTGYLISYSSMLGAVAGLALGPILRLYKHNSQALLLHSSILTCTLLLLYSLAPTMGAVVLSSTLLSFSTAIGRT 252
Cdd:cd17390  203 FDLSPKTIGYLISYSGVLGALSGFLVGRILKLYKNNEYLLLLHSFILLALSLLGLALAPSIWLLVLCLTPLSISSAVLRT 282

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767920176 253 CITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGVAQEVSPCGPPSLGAVLALVAIFIMSLNKR 320
Cdd:cd17390  283 CSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLLQEFSVSGPGLLGAVLALAAILLMLARQR 350
MFS_1 pfam07690
Major Facilitator Superfamily;
13-286 1.18e-12

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 67.83  E-value: 1.18e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176   13 ALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELeDGFYLTAFICFLVFILNAGLVWFFPwreakpgstekglp 92
Cdd:pfam07690 108 ALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL-FGWRAAFLILAILSLLAAVLLLLPR-------------- 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176   93 lrkthvllgrshdtvqEAATSRRARASKKTAQPWVEVVLALRNMKNLLfsemwdiFLVRLLMAMAVMLYYSNFVLALEER 172
Cdd:pfam07690 173 ----------------PPPESKRPKPAEEARLSLIVAWKALLRDPVLW-------LLLALLLFGFAFFGLLTYLPLYQEV 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  173 FGVRPKVTGYLISYSSMLGAVAGLALGPILRLYKHNSQALLLHSSILTCTL-LLLYSLAPTMGAVVLSSTLLSFSTAIGR 251
Cdd:pfam07690 230 LGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALgLLLLSLTLSSLWLLLALLLLGFGFGLVF 309

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 767920176  252 TCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAP 286
Cdd:pfam07690 310 PALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
13-281 4.88e-10

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 59.99  E-value: 4.88e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  13 ALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEdGFYLTAFICFLVFILNAGLVWFFpwreakpgstekglp 92
Cdd:COG2814  121 ALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF-GWRWVFLVNAVLALLALLLLLRL--------------- 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  93 lrkthvllgrshdtVQEAATSRRARASKKTAQPWVEVVLALrnmknllfsemwdIFLVRLLMAMAVMLYYSNFVLALEER 172
Cdd:COG2814  185 --------------LPESRPAARARLRGSLRELLRRPRLLL-------------LLLLAFLLGFGFFALFTYLPLYLQEV 237

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176 173 FGVRPKVTGYLISYSSMLGAVAGLALGPILRlyKHNSQALLLHSSILTCTLLLLYSLAPTMGAVVLSSTLLSFSTAIGRT 252
Cdd:COG2814  238 LGLSASAAGLLLALFGLGGVLGALLAGRLAD--RFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFP 315

                        250       260
                 ....*....|....*....|....*....
gi 767920176 253 CITDLQLTVGGAQASGTLIGVGQSVTAVG 281
Cdd:COG2814  316 LLQALVAELAPPEARGRASGLYNSAFFLG 344
 
Name Accession Description Interval E-value
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 13-320 3.80e-101

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 301.45  E-value: 3.80e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  13 ALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEDGFYLTAFICFLVFILNAGLVWFFPwreakpgstekglp 92
Cdd:cd17390  106 AYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDGGFYYVALLCSAIFILNAGLVWFLL-------------- 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  93 lrkthvllgrshdtvqeaatsrraraskktaqpwvevvlalrnmknllfSEMWDIFLVRLLMAMAVMLYYSNFVLALEER 172
Cdd:cd17390  172 -------------------------------------------------SKLWDLLLVRFLMGFSVLLFRSNFSLYLEER 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176 173 FGVRPKVTGYLISYSSMLGAVAGLALGPILRLYKHNSQALLLHSSILTCTLLLLYSLAPTMGAVVLSSTLLSFSTAIGRT 252
Cdd:cd17390  203 FDLSPKTIGYLISYSGVLGALSGFLVGRILKLYKNNEYLLLLHSFILLALSLLGLALAPSIWLLVLCLTPLSISSAVLRT 282

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767920176 253 CITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGVAQEVSPCGPPSLGAVLALVAIFIMSLNKR 320
Cdd:cd17390  283 CSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLLQEFSVSGPGLLGAVLALAAILLMLARQR 350
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 13-317 6.45e-36

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 132.70  E-value: 6.45e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  13 ALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELeDGFYLTAFICFLVFILNAGLVWFFPWReakpgstekglp 92
Cdd:cd17330  109 AYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTP-YGYALPFLVAAALALLNLVLVLFFLPP------------ 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  93 lrkthvllgrshdtvqeaatsrraraskktaqpwvevvlalrnmknllfseMWDIFLVRLLMAMAVMLYYSNFVLALEER 172
Cdd:cd17330  176 ---------------------------------------------------LRRLLLVYFLIALAFAGLESVFSLFLKDR 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176 173 FGVRPKVTGYLISYSSMLGAVAGLALGPILRlYKHNSQALLLHSSILTCTLLLLYSLAPTMGAVVLSSTLLSFSTAIGRT 252
Cdd:cd17330  205 FGFSPSQIGLLLALVGIAGILAQLLLIPRLA-KRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFP 283

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767920176 253 CITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGVA-QEVSPCGPPSLGAVLALVAIFIMSL 317
Cdd:cd17330  284 ALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLySFLGPGVPFLLAAGLLLIALFLLSL 349
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 13-317 2.93e-25

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 104.61  E-value: 2.93e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  13 ALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEdGFYLTAFICFLVFILNAGLVWFFPwreakPGSTekglp 92
Cdd:cd17331  109 MVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKF-GEQAAALVAAVGSLLSIVLVILLI-----PSNT----- 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  93 lrkthvllgrshdtvQEAATSRRARASKKTAQPWVEVVLALRNMKNLlfsemWDIFLVRLLMAMAVMLYYSNFVLALEER 172
Cdd:cd17331  178 ---------------KSKREKEAKESASPPSVFNLKEILRLLRLPGV-----AFLLLVKLLSGLPIGMFQSMFSLVAMDF 237

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176 173 FGVRPKVTGYLISYSSMLGAVAGLALGPILRLyKHNSQALLLHSSILTCTLLLLYSLAPTMGAVVLSSTLLSFSTAIGRT 252
Cdd:cd17331  238 FGLTPEENGYLMSYAGVLGMVVQGLLVGPLTK-RFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYT 316

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767920176 253 CITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGVA-QEVSPCGPPSLGAVLALVAIFIMSL 317
Cdd:cd17331  317 VITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALlQAYGFPSFGLLGAAINGLLTVYLLL 382
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 13-317 1.74e-17

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 82.24  E-value: 1.74e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  13 ALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEdGFYLTAFICFLVFILNAGLVWFFPWREAKPGSTEKGLP 92
Cdd:cd17325  107 ALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL-GYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSA 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  93 LRKTHVLLGRSHDtvqeaatsrraraskktaqpwvevvlalrnmknllfSEMWDIFLVRLLMAMAVMLYYSNFVLALEER 172
Cdd:cd17325  186 ARLRSGLRLLLRD------------------------------------RRLLALFLAIFVLAFAFGALEPFLPLYAAEL 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176 173 FGVRPKVTGYLISYSSMLGAVAGLALGPIlrLYKHNSQALLLHSSILTCTLLLLYSLAPTMGAVVLSSTLLSFSTAIGRT 252
Cdd:cd17325  230 GGLSPAQIGLLFGAQGLASALSQPPAGKL--SDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFP 307

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767920176 253 CITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSG-VAQEVSPCGPPSLGAVLALVAIFIMSL 317
Cdd:cd17325  308 ATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGfLYDAFGFATPFLAAAALLLLAAVLFLL 373
MFS_1 pfam07690
Major Facilitator Superfamily;
13-286 1.18e-12

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 67.83  E-value: 1.18e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176   13 ALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELeDGFYLTAFICFLVFILNAGLVWFFPwreakpgstekglp 92
Cdd:pfam07690 108 ALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL-FGWRAAFLILAILSLLAAVLLLLPR-------------- 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176   93 lrkthvllgrshdtvqEAATSRRARASKKTAQPWVEVVLALRNMKNLLfsemwdiFLVRLLMAMAVMLYYSNFVLALEER 172
Cdd:pfam07690 173 ----------------PPPESKRPKPAEEARLSLIVAWKALLRDPVLW-------LLLALLLFGFAFFGLLTYLPLYQEV 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  173 FGVRPKVTGYLISYSSMLGAVAGLALGPILRLYKHNSQALLLHSSILTCTL-LLLYSLAPTMGAVVLSSTLLSFSTAIGR 251
Cdd:pfam07690 230 LGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALgLLLLSLTLSSLWLLLALLLLGFGFGLVF 309

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 767920176  252 TCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAP 286
Cdd:pfam07690 310 PALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 3-317 1.75e-10

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 61.29  E-value: 1.75e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176   3 FCNSFLAHWWALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEDGFYLTAFICFLVFILNAGLVWFFPWREA 82
Cdd:cd06174   97 GSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDP 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  83 KPGSTEKGlplrkthvllgrshdtvqeaatsrrarASKKTAQPWVEVVLALRNMKnllfseMWDIFLVRLLMAMAVMLYY 162
Cdd:cd06174  177 PESARAKN---------------------------EEASSKSVLKLLKRVLKNPG------LWLLLLAIFLVNLAYYSFS 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176 163 SNFVLALEERFGVRPKVTGYLISYSSMLGAVAGLALGPILRLYKHNSQALLLHSSILTCTLLLLYsLAPTMGAVVLSSTL 242
Cdd:cd06174  224 TLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLL-LAPSLLLLLLLLLL 302

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767920176 243 LSFSTAIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGVAQEVSPCGPPSLGAVLALVAIFIMSL 317
Cdd:cd06174  303 LGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
13-281 4.88e-10

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 59.99  E-value: 4.88e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  13 ALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEdGFYLTAFICFLVFILNAGLVWFFpwreakpgstekglp 92
Cdd:COG2814  121 ALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF-GWRWVFLVNAVLALLALLLLLRL--------------- 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  93 lrkthvllgrshdtVQEAATSRRARASKKTAQPWVEVVLALrnmknllfsemwdIFLVRLLMAMAVMLYYSNFVLALEER 172
Cdd:COG2814  185 --------------LPESRPAARARLRGSLRELLRRPRLLL-------------LLLLAFLLGFGFFALFTYLPLYLQEV 237

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176 173 FGVRPKVTGYLISYSSMLGAVAGLALGPILRlyKHNSQALLLHSSILTCTLLLLYSLAPTMGAVVLSSTLLSFSTAIGRT 252
Cdd:COG2814  238 LGLSASAAGLLLALFGLGGVLGALLAGRLAD--RFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFP 315

                        250       260
                 ....*....|....*....|....*....
gi 767920176 253 CITDLQLTVGGAQASGTLIGVGQSVTAVG 281
Cdd:COG2814  316 LLQALVAELAPPEARGRASGLYNSAFFLG 344
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 13-314 4.73e-09

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 57.20  E-value: 4.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  13 ALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELedGFYLtAFICFLVFILNAGLVWFFpwreakpgstekglp 92
Cdd:cd17474  110 TLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI--SWRY-PFFLLAALIPVAFLAILF--------------- 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  93 lrkthvLLGRSHDTVQEAATSRRARASKKTAQPWVEVVLALRNMKNLLFsemwdiFLVrllmamavmLYYSNFVLalEER 172
Cdd:cd17474  172 ------LLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLY------FAF---------LTYLPFLL--ELL 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176 173 FGVRPKVTGYLISYSSMLGAVAGLALGPILRLyKHNSQALLLHSSILTCTLLLLYSLAPTMGAVVLSSTLLSFSTAIGRT 252
Cdd:cd17474  229 YGISPIIIGLLFAGWSVLLALGSLFVGRLLKK-RFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLP 307

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767920176 253 CITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSG-VAQEVSPCGPPSLGAVLALVAIFI 314
Cdd:cd17474  308 LLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGlLLEIFGLSAPFLVGAAIALAAAVL 370
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 13-315 6.52e-08

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 53.35  E-value: 6.52e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  13 ALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEdgfYLTAFICFLVFILNAGLVWFFPWreakpgstekglp 92
Cdd:cd17473  111 ALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIG---WRAPFLVYLLALPVLILVLLFLP------------- 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  93 lrkthvllgrshDTVQEAATSRRARASKKTAQPWVEVVLALrnmknllfsemwdiflvrLLMAMAVMLYYS---NFVLAL 169
Cdd:cd17473  175 ------------EPARKSKSAASPGAATAAALPWKRVLPIY------------------FLAFLAMLLFYVipiQLPFLL 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176 170 EERFGVRPKVTGYLISYSSMLGAVAGLALGPILRLYKHnsQALLLHSSILTCTLLLLYSLAPTMGAVVLSSTLLSFSTAI 249
Cdd:cd17473  225 QERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGK--RRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGL 302

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767920176 250 GRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSG--VAQEVSPCGPPSLGAVLALVAIFIM 315
Cdd:cd17473  303 LLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGplVNLTGGLSGAFLILGVLALVLAIVL 370
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 13-77 2.45e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 48.73  E-value: 2.45e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767920176  13 ALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEdGFYLTAFICFLVFILNAGLVWFF 77
Cdd:cd17325  311 ALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF-GFATPFLAAAALLLLAAVLFLLL 374
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 13-315 2.75e-06

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 48.40  E-value: 2.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  13 ALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTE--LEDGFYLTAFICFLVFIlnagLVWFFpwreakpgstekg 90
Cdd:cd17388  113 AYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEisPRAPFLVAAGLNGLNFL----LGLFV------------- 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  91 lpLRKTHvllgrshdtvqeaATSRRARASKKTAQPWVEVVlALRNMKNLLFsemwdIFLVRLLMAMAVMLYYSNFVLALE 170
Cdd:cd17388  176 --LPESL-------------PPERRRAFRWRRANPFGSLR-WLTGFPGLLG-----LLAVFFLIQLIGQVPATTWVLFTE 234

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176 171 ERFGVRPKVTGYLISYSSMLGAVA-GLALGPILRlyKHNSQALLLHSSILTCTLLLLYSLAPTmGAVVLSSTLLSFSTAI 249
Cdd:cd17388  235 DRFDWSPTMVGLSLAVFGLLHALFqAFVTGPIAK--RLGEKRAILLGLAADALGFLLLAFATQ-GWMVFPILILLALGGI 311

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176 250 GRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGVAQEVSPCGPPSL----GAVLALVAIFIM 315
Cdd:cd17388  312 AGPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAASPATWPGLawiiGAALYLICLVLA 381
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
13-320 4.72e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 47.56  E-value: 4.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  13 ALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELED---GFYLTAFICFLVFILNaglvwffpwreakpgstek 89
Cdd:COG2271  121 KLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGwraAFLILGLPGLLLALLR------------------- 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  90 glplrkthvllgrshdtvqeaatsrraraskktaqpwvevvlalrnmknllfseMWDIFLVRLLMAMAVMLYYSNFVLAL 169
Cdd:COG2271  182 ------------------------------------------------------FWLLALAYFLVYFALYGFLTWLPTYL 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176 170 EERFGVRPKVTGYLISYSSMLGAVAGLALGPILRLYKHNSQALLLHSSILTCTLLLLYSLAPTMGAVVLSSTLLSFSTAI 249
Cdd:COG2271  208 VEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGG 287

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767920176 250 GRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGVAQEVSPCGPP-SLGAVLALVAIFIMSLNKR 320
Cdd:COG2271  288 AFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAfLLLAALALLAALLALLLLR 359
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 185-315 3.41e-05

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 45.34  E-value: 3.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176 185 SYSSM--------LGAVAGLALGPILRLYKHNSQALLLHSSILTCTL-LLLYSLAPTMGAVVLSSTLLSFSTAIGRTCIT 255
Cdd:cd17389  247 QYTSMqqgkmfffIGIIMALVQGGYVRRIKPGKEKKAVLQGLILLIPaFLLIGWASSVTVLYAGLFLYSFAAATVVPCLT 326

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767920176 256 DLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLL-SGVAQEVSPCGPPSLGAVLALVAIFIM 315
Cdd:cd17389  327 TLVSGYGSDDQKGTVMGIFRSLGALARALGPIVaCTVYWLAGSEACYTIGALLFLLPLLLL 387
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 12-291 4.69e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 44.53  E-value: 4.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  12 WALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLteLEDGFYLTAFICFLVFILNAGLVWFfpwreakpgstekgl 91
Cdd:cd17329  110 EAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLL--LLYSFRLLFLAAAVLFLLAALVLLF--------------- 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  92 plrkthvllgrshdTVQEAATSRRARASKKTAQPWVEVvlaLRNMKNLLFsemwdiFLVRLLMAMAVMLYYSNFVLALEE 171
Cdd:cd17329  173 --------------LLPETRPKRRAAEKTEILRGYKIV---LRDRAFLLF------LLASFLISLIYFQLESTLPVYVVE 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176 172 RFGVRPKVTGYLISYSSMLGAVAGLalgPILRLYKHNSQALLLHSSILTCTL-LLLYSLAPTMGAVVLSSTLLSFSTAIG 250
Cdd:cd17329  230 ILGLGESLLGLLLALNALLIVLLQF---PVARLVERFRLRKILMIGILLFAIgFAVLAFANTLAVLILAMIVLTLGEMLV 306

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 767920176 251 RTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGV 291
Cdd:cd17329  307 FPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGL 347
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
22-317 1.16e-04

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 43.32  E-value: 1.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  22 KERPLVIGHFNTASGVGFILGPVVGGYLTELEDgfYLTAFICFLVFILNAGLVWFFPWREAKPGSTEKGLPLRKTHVLlg 101
Cdd:COG2807  137 DRVGLMTGLYTAAMGLGAALAAGLTVPLAAALG--WRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRSLW-- 212

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176 102 rshdtvqeaatsrraraskKTAQPWvevvlalrnmknllfsemwdifLVRLLMAMAVMLYYSNFVL--ALEERFGVRPKV 179
Cdd:COG2807  213 -------------------RSPLAW----------------------LLTLFFGLQSLLYYAVVAWlpPILRDAGLSAAT 251

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176 180 TGYLISYSSMLGAVAGLALGPILRLYKHNSQALLLhSSILTCTLLLLYSLAPTmGAVVLSSTLLSFSTAIGRT-CITDLQ 258
Cdd:COG2807  252 AGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLL-LGLLGLAGLLGLLLAPG-SLPWLWAVLLGLGQGGLFPlALTLIG 329

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767920176 259 LTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGVAQEVSpcGPPSLGAVLALVAIFIMSL 317
Cdd:COG2807  330 LRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDAT--GSWTAALLLLAALAVLMLV 386
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 2-77 1.49e-04

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 42.94  E-value: 1.49e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767920176   2 AFCNSFLAHWWALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEDGFYLtAFICFLVFILNAGLVWFF 77
Cdd:cd17319  283 FGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTA-AFLFLAAVALLAALLVLL 357
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 13-51 1.52e-04

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 42.94  E-value: 1.52e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 767920176  13 ALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTE 51
Cdd:cd17502  106 IIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTD 144
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 2-78 2.43e-04

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 42.56  E-value: 2.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176   2 AFCNSFLAHWWALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELED---GFYLTAFICFLVFILnagLVWFFP 78
Cdd:cd17323   99 FFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGwrwIFWFLAIISGFCLIL---IFLFLP 175
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
11-314 3.65e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 42.20  E-value: 3.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  11 WWALLSDVVPE-KERPLVIGHFNTASGVGFILGPVVGGYLTEL-----EDGFYLTAFICFLVFILnAGLVWFFPWREAKP 84
Cdd:COG2211  131 YSALGAELTPDyEERTRLSSWRFAFAGLGGLLASVLPPPLVAAfggdaALGYRLTALIFAVLGLL-AFLLTFFGTKERPV 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  85 GSTEKglplrkthvllgrshdtvqeaatsrraraskktaQPWVEVVLALRNMKNLLFsemwdIFLVRLLMAMAVMLYYSN 164
Cdd:COG2211  210 PEEEK----------------------------------VSLKESLKALLKNRPFLL-----LLLAYLLFFLALALVAAL 250

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176 165 FVLALEERFGVRPKVTGYLISYSSMLGAVAGLALGPILRLY-KHNsqALLLHSSILTCTLLLLYSLAPT-----MGAVVL 238
Cdd:COG2211  251 LLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFgKKK--AFIIGLLLAALGLLLLFFLGPGnlwllLVLAAL 328

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176 239 SSTLLSFSTAIGRTCITDL---QLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGVAQEVS---PCGPPSLGAVLALVAI 312
Cdd:COG2211  329 AGIGLGAILVLPWAMLADVvdyDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFgyvAGAAQSPSALTGIRLL 408


                 ..
gi 767920176 313 FI 314
Cdd:COG2211  409 FF 410
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 12-78 5.80e-04

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 41.46  E-value: 5.80e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767920176  12 WALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEDG-----FYLTAFICFLVFILnaGLVWFFP 78
Cdd:cd06179  106 AAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAAgwrwiFYINAIFNALALIL--LFFFYHP 175
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 13-69 6.64e-04

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 41.00  E-value: 6.64e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  13 ALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELED---GFYLTAFICFLVFIL 69
Cdd:cd17321  107 ALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGwrwIFLINVPIGLVALLL 166
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 13-95 8.87e-04

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 40.71  E-value: 8.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  13 ALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELED---GFYLTAFICFLVFIlnagLVWFFPWREAKPGSTEK 89
Cdd:cd17391  111 ALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGirnVFFITGGLLFLAFL----LTLFFVKEDFKPVEKKK 186


                 ....*.
gi 767920176  90 GLPLRK 95
Cdd:cd17391  187 MVSTKE 192
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
13-320 1.58e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 39.86  E-value: 1.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  13 ALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLteLEDGFYLTAFICFLVFILNAGLVWFFPWREAKPGSTEKglp 92
Cdd:COG2223  116 ALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLL--IAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAA--- 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  93 lrkthvllgrshdtvqEAATSRRARASKKTAQPWVevvlalrnmknllfsemwdIFLVRLLMAMAVMLYYSNFVLALEER 172
Cdd:COG2223  191 ----------------AKASLRDQLEALRDPRFWL-------------------LSLLYFGTFGSFIGFSSWLPPYLVDQ 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176 173 FGVRPKVTGYLISYSSMLGAVAGLALGPIL-RLYKHNSQALLLhsSILTCTLLLLYSLAPTMGAVVLSSTLLSFSTAIGR 251
Cdd:COG2223  236 FGLSAATAGLLAALFALLGALGRPLGGWLSdRIGGRRVLLIVF--ALMALGLLLLALALGSLWLFLVLFLLLGLALGGGN 313

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767920176 252 TCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGVAQEVSpcGPPSLG----AVLALVAIFIMSLNKR 320
Cdd:COG2223  314 GAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAT--GSYTAAflvfAVLALVALVLTLLLYR 384
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 11-317 1.67e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 39.91  E-value: 1.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  11 WWALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELeDGFYLTAFICFLVFILNAGLVWFFPWREAKPGSTEKG 90
Cdd:cd06173  113 RQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVAL-LGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSS 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  91 LPLRKTHVLLgrshdtvqeaatsRRARASKktaqpwvevvlalrnmknllfsEMWDIFLVRLLMAMAVMLYYSNFVLALE 170
Cdd:cd06173  192 LLLRDLREGL-------------RYLRRSP----------------------LLRLLLLALALFALLGGALTVLLPLLAK 236

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176 171 ERFGVRPKVTGYLISYSSMLGAVAGLALGPILRLYKHNSqaLLLHSSILTCTLLLLYSLAPTMGAVVLSSTLLSFSTAIG 250
Cdd:cd06173  237 EVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGR--LLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLF 314

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767920176 251 RTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGVAQEVSPCGPP--SLGAVLALVAIFIMSL 317
Cdd:cd06173  315 NVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVflLAGALLLLAALLLLLL 383
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
13-321 2.61e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 39.45  E-value: 2.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  13 ALLSDVVPEKERPLvIGHFNTASGVGFILGPVVGGYLTELEDGFYLTA--FICFLVFILNAGLVWFFPWREAKPGSTEKG 90
Cdd:COG0738  119 PYVAALGPETAASR-LNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLpyLILAVLLLLLALLFLRSKLPEIEEEEEEAA 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  91 LPLRKTHVLLGRSHdtvqeaatsrraraskktaqpwvevvlalrnmknllfseMWDIFLVRLLMAMAVMLYYSNFVLALE 170
Cdd:COG0738  198 GSAASLKSLLKNPR---------------------------------------LLLGGLAIFLYVGAEGAIGDWLPLYLK 238

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176 171 ERFGVRPKVTGYLISYSSMLGAVAGLALGPILRlyKHNSQALLLHSSILTCTLLLLYSLAPTMGAVVLSSTLLSFSTAIG 250
Cdd:COG0738  239 DVLGLSEATAALGLSLFWGGMTIGRFLGGFLLK--RFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLM 316

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767920176 251 RTCITDLQLTVGGAqASGTLIGVGQSVTAVGRIIAPLLSG-VAQEVSPCGPPSLGAVLALVAIFIMSLNKRH 321
Cdd:COG0738  317 FPTIFSLALDGLGK-RTAAAVSAVLIMGIVGGAIGPPLIGfLADAFGLRAAFLVPLVCYLLILLLALALKRK 387
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
148-333 3.32e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 38.80  E-value: 3.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176 148 FLVRLLMAMAVMLYYSNFVL-----ALEERFGVRPKVTGYLISYSSMLGAVAGLALGPILRLYkhNSQALLLHSSILTCT 222
Cdd:COG2814   10 LALLALALGAFLSGLGIGIVlpalpLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRF--GRRRVLLLGLLLFAL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176 223 LLLLYSLAPTMGAVVLSSTLLSFSTAIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGV-AQEVSPCGPP 301
Cdd:COG2814   88 GSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLlADLFGWRWVF 167

                        170       180       190
                 ....*....|....*....|....*....|..
gi 767920176 302 SLGAVLALVAIFIMSLNKRHSSGDGNSKLKSE 333
Cdd:COG2814  168 LVNAVLALLALLLLLRLLPESRPAARARLRGS 199
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 13-102 5.36e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 38.34  E-value: 5.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176  13 ALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEdGFYLTAFICFLVFILNAGLVWFFPWREAKPGSTEKGLP 92
Cdd:cd17489  107 TLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHL-GFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGT 185

                         90
                 ....*....|
gi 767920176  93 LRKTHVLLGR 102
Cdd:cd17489  186 RAFRRLVEKK 195
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
1-83 7.91e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 37.54  E-value: 7.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920176   1 MAFCNSFLAHWWALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELedGFYLTAFICFLVFILNAGLVWFFPWR 80
Cdd:COG2271  282 GFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDA--TGYQAAFLLLAALALLAALLALLLLR 359


                 ...
gi 767920176  81 EAK 83
Cdd:COG2271  360 ETR 362
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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