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Conserved domains on  [gi|767926952|ref|XP_011511212|]
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interleukin-20 receptor subunit beta isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 33-129 1.06e-29

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


:

Pssm-ID: 460067  Cd Length: 107  Bit Score: 109.01  E-value: 1.06e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926952   33 SGDEVAILPAPQNLSVLSTNMKHLLMWSPVIAPGETVYYSVEYQgeyesLYTSHIWIPSSWCSLTEGPECDVTDDIT-AT 111
Cdd:pfam01108  15 SAAGGPSLPAPQNVTFQSTNFKNILTWEPGPNSPPDVVYTVQYK-----IYGSGDWKNVPNCTNITRTECDLTDETSdLT 89

                          90
                  ....*....|....*...
gi 767926952  112 VPYNLRVRATLGSQTSAW 129
Cdd:pfam01108  90 ETYYARVRAVSGGGTSSW 107
Interfer-bind super family cl46366
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 141-230 8.06e-04

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


The actual alignment was detected with superfamily member pfam09294:

Pssm-ID: 480706  Cd Length: 103  Bit Score: 38.09  E-value: 8.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926952  141 TILTRPGMEITKDGFHLVI-------------ELEDLGPQFEFLVAYWR-REPGAEEHVKMVRSGgipVHLETMEPGAAY 206
Cdd:pfam09294   1 TIIGPPEVELEVEGGSLNVtvkdpetregknlSLRDLYGSLQYRVSYWKnSSNGEKKNTTSTNSF---VVLSDLEPGTTY 77

                          90       100
                  ....*....|....*....|....
gi 767926952  207 CVKAQTFVKAIGRYSAFSQTECVE 230
Cdd:pfam09294  78 CVSVQAFSPLDNKSSQRSPPQCIR 101
 
Name Accession Description Interval E-value
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 33-129 1.06e-29

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 109.01  E-value: 1.06e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926952   33 SGDEVAILPAPQNLSVLSTNMKHLLMWSPVIAPGETVYYSVEYQgeyesLYTSHIWIPSSWCSLTEGPECDVTDDIT-AT 111
Cdd:pfam01108  15 SAAGGPSLPAPQNVTFQSTNFKNILTWEPGPNSPPDVVYTVQYK-----IYGSGDWKNVPNCTNITRTECDLTDETSdLT 89

                          90
                  ....*....|....*...
gi 767926952  112 VPYNLRVRATLGSQTSAW 129
Cdd:pfam01108  90 ETYYARVRAVSGGGTSSW 107
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 141-230 8.06e-04

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 38.09  E-value: 8.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926952  141 TILTRPGMEITKDGFHLVI-------------ELEDLGPQFEFLVAYWR-REPGAEEHVKMVRSGgipVHLETMEPGAAY 206
Cdd:pfam09294   1 TIIGPPEVELEVEGGSLNVtvkdpetregknlSLRDLYGSLQYRVSYWKnSSNGEKKNTTSTNSF---VVLSDLEPGTTY 77

                          90       100
                  ....*....|....*....|....
gi 767926952  207 CVKAQTFVKAIGRYSAFSQTECVE 230
Cdd:pfam09294  78 CVSVQAFSPLDNKSSQRSPPQCIR 101
 
Name Accession Description Interval E-value
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 33-129 1.06e-29

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 109.01  E-value: 1.06e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926952   33 SGDEVAILPAPQNLSVLSTNMKHLLMWSPVIAPGETVYYSVEYQgeyesLYTSHIWIPSSWCSLTEGPECDVTDDIT-AT 111
Cdd:pfam01108  15 SAAGGPSLPAPQNVTFQSTNFKNILTWEPGPNSPPDVVYTVQYK-----IYGSGDWKNVPNCTNITRTECDLTDETSdLT 89

                          90
                  ....*....|....*...
gi 767926952  112 VPYNLRVRATLGSQTSAW 129
Cdd:pfam01108  90 ETYYARVRAVSGGGTSSW 107
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 141-230 8.06e-04

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 38.09  E-value: 8.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926952  141 TILTRPGMEITKDGFHLVI-------------ELEDLGPQFEFLVAYWR-REPGAEEHVKMVRSGgipVHLETMEPGAAY 206
Cdd:pfam09294   1 TIIGPPEVELEVEGGSLNVtvkdpetregknlSLRDLYGSLQYRVSYWKnSSNGEKKNTTSTNSF---VVLSDLEPGTTY 77

                          90       100
                  ....*....|....*....|....
gi 767926952  207 CVKAQTFVKAIGRYSAFSQTECVE 230
Cdd:pfam09294  78 CVSVQAFSPLDNKSSQRSPPQCIR 101
fn3 pfam00041
Fibronectin type III domain;
41-130 2.89e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 36.24  E-value: 2.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926952   41 PAPQNLSVLSTNMKHL-LMWSPVIAPGETV-YYSVEYQGEYESLYTSHIWIPSSWCSLTegpecdVTdDITATVPYNLRV 118
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLtVSWTPPPDGNGPItGYEVEYRPKNSGEPWNEITVPGTTTSVT------LT-GLKPGTEYEVRV 73

                          90
                  ....*....|..
gi 767926952  119 RATLGSQTSAWS 130
Cdd:pfam00041  74 QAVNGGGEGPPS 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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