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Conserved domains on  [gi|767927290|ref|XP_011511343|]
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sentrin-specific protease 7 isoform X3 [Homo sapiens]

Protein Classification

C48 family peptidase( domain architecture ID 581147)

C48 family peptidase similar to sentrin-specific proteases (SUMO proteases) that catalyze the processing of small ubiquitin-like modifier (SUMO) propeptides

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Peptidase_C48 super family cl23802
Ulp1 protease family, C-terminal catalytic domain; This domain contains the catalytic triad ...
709-946 1.03e-22

Ulp1 protease family, C-terminal catalytic domain; This domain contains the catalytic triad Cys-His-Asn.


The actual alignment was detected with superfamily member pfam02902:

Pssm-ID: 420019  Cd Length: 202  Bit Score: 97.14  E-value: 1.03e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927290  709 EFLNDVIIDFYLKYLI-LEKASDELVERSHIFSSFFYKCLTRKennlteDNPNLSMAQRRHKRVRTWTR--HINIFNKDY 785
Cdd:pfam02902   1 EWLNDTVIDFYLKLLAhRLESEDYKNERVHFLNSFFYSKLTSK------VSFKWGKKKDFYNGVRRWTRknKKWLFDVDI 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927290  786 IFVPVNE-SSHWYLAVICFPwleeavyedfpqtvsqqsqaqqsqndNKTIDndlrttsTLslsaeDSQSTesnmSVPKKM 864
Cdd:pfam02902  75 IYIPINWdGKHWVLLIINLP--------------------------KKTIT-------IL-----DSLIS----LHTDKE 112
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927290  865 CKRPCILILDSLKAASVqNTVQNLREYLEVEWEVklkthrqfsktnmvdlCPKVPKQDNSSDCGVYLLQYVESFFKDPIV 944
Cdd:pfam02902 113 YIRPINAMLPYLMSEAL-KKEQDDPDLTPFEIKR----------------LTKVPQQPNSGDCGPYVLKFIELLAEGVPF 175

                  ..
gi 767927290  945 NF 946
Cdd:pfam02902 176 EF 177
 
Name Accession Description Interval E-value
Peptidase_C48 pfam02902
Ulp1 protease family, C-terminal catalytic domain; This domain contains the catalytic triad ...
709-946 1.03e-22

Ulp1 protease family, C-terminal catalytic domain; This domain contains the catalytic triad Cys-His-Asn.


Pssm-ID: 397169  Cd Length: 202  Bit Score: 97.14  E-value: 1.03e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927290  709 EFLNDVIIDFYLKYLI-LEKASDELVERSHIFSSFFYKCLTRKennlteDNPNLSMAQRRHKRVRTWTR--HINIFNKDY 785
Cdd:pfam02902   1 EWLNDTVIDFYLKLLAhRLESEDYKNERVHFLNSFFYSKLTSK------VSFKWGKKKDFYNGVRRWTRknKKWLFDVDI 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927290  786 IFVPVNE-SSHWYLAVICFPwleeavyedfpqtvsqqsqaqqsqndNKTIDndlrttsTLslsaeDSQSTesnmSVPKKM 864
Cdd:pfam02902  75 IYIPINWdGKHWVLLIINLP--------------------------KKTIT-------IL-----DSLIS----LHTDKE 112
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927290  865 CKRPCILILDSLKAASVqNTVQNLREYLEVEWEVklkthrqfsktnmvdlCPKVPKQDNSSDCGVYLLQYVESFFKDPIV 944
Cdd:pfam02902 113 YIRPINAMLPYLMSEAL-KKEQDDPDLTPFEIKR----------------LTKVPQQPNSGDCGPYVLKFIELLAEGVPF 175

                  ..
gi 767927290  945 NF 946
Cdd:pfam02902 176 EF 177
PLN03189 PLN03189
Protease specific for SMALL UBIQUITIN-RELATED MODIFIER (SUMO); Provisional
697-801 8.89e-09

Protease specific for SMALL UBIQUITIN-RELATED MODIFIER (SUMO); Provisional


Pssm-ID: 215622 [Multi-domain]  Cd Length: 490  Bit Score: 59.09  E-value: 8.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927290 697 VTNEDLECLEEGEFLNDVIIDFYLKYLI-LEKASDELVERSHIFSSFFYKCLTRKENNLTednpnlsmaqrrHKRVRTWT 775
Cdd:PLN03189 290 ITGEILRCLKPGAWLNDEVINLYLELLKeREAREPKKFLKCHFFNTFFYKKLVSGKSGYD------------YKAVRRWT 357
                         90       100       110
                 ....*....|....*....|....*....|
gi 767927290 776 --RHINIFNK--DYIFVPVNESSHWYLAVI 801
Cdd:PLN03189 358 tqKKLGYHLIdcDKIFVPIHQEIHWTLAVI 387
 
Name Accession Description Interval E-value
Peptidase_C48 pfam02902
Ulp1 protease family, C-terminal catalytic domain; This domain contains the catalytic triad ...
709-946 1.03e-22

Ulp1 protease family, C-terminal catalytic domain; This domain contains the catalytic triad Cys-His-Asn.


Pssm-ID: 397169  Cd Length: 202  Bit Score: 97.14  E-value: 1.03e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927290  709 EFLNDVIIDFYLKYLI-LEKASDELVERSHIFSSFFYKCLTRKennlteDNPNLSMAQRRHKRVRTWTR--HINIFNKDY 785
Cdd:pfam02902   1 EWLNDTVIDFYLKLLAhRLESEDYKNERVHFLNSFFYSKLTSK------VSFKWGKKKDFYNGVRRWTRknKKWLFDVDI 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927290  786 IFVPVNE-SSHWYLAVICFPwleeavyedfpqtvsqqsqaqqsqndNKTIDndlrttsTLslsaeDSQSTesnmSVPKKM 864
Cdd:pfam02902  75 IYIPINWdGKHWVLLIINLP--------------------------KKTIT-------IL-----DSLIS----LHTDKE 112
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927290  865 CKRPCILILDSLKAASVqNTVQNLREYLEVEWEVklkthrqfsktnmvdlCPKVPKQDNSSDCGVYLLQYVESFFKDPIV 944
Cdd:pfam02902 113 YIRPINAMLPYLMSEAL-KKEQDDPDLTPFEIKR----------------LTKVPQQPNSGDCGPYVLKFIELLAEGVPF 175

                  ..
gi 767927290  945 NF 946
Cdd:pfam02902 176 EF 177
PLN03189 PLN03189
Protease specific for SMALL UBIQUITIN-RELATED MODIFIER (SUMO); Provisional
697-801 8.89e-09

Protease specific for SMALL UBIQUITIN-RELATED MODIFIER (SUMO); Provisional


Pssm-ID: 215622 [Multi-domain]  Cd Length: 490  Bit Score: 59.09  E-value: 8.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927290 697 VTNEDLECLEEGEFLNDVIIDFYLKYLI-LEKASDELVERSHIFSSFFYKCLTRKENNLTednpnlsmaqrrHKRVRTWT 775
Cdd:PLN03189 290 ITGEILRCLKPGAWLNDEVINLYLELLKeREAREPKKFLKCHFFNTFFYKKLVSGKSGYD------------YKAVRRWT 357
                         90       100       110
                 ....*....|....*....|....*....|
gi 767927290 776 --RHINIFNK--DYIFVPVNESSHWYLAVI 801
Cdd:PLN03189 358 tqKKLGYHLIdcDKIFVPIHQEIHWTLAVI 387
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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