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probable E3 SUMO-protein ligase RNF212 isoform X6 [Homo sapiens]
RING-HC_RNF212 domain-containing protein( domain architecture ID 11616577)
RING-HC_RNF212 domain-containing protein
List of domain hits
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Name | Accession | Description | Interval | E-value | ||
RING-HC_RNF212 | cd16746 | RING finger, HC subclass, found in RING finger protein 212 (RNF212) and similar proteins; ... |
4-50 | 1.07e-20 | ||
RING finger, HC subclass, found in RING finger protein 212 (RNF212) and similar proteins; RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis. It plays a central role in designating crossover sites and coupling chromosome synapsis to the formation of crossover-specific recombination complexes. It also functions as an E3 ligase for SUMO modification. RNF212 contains an N-terminal C3HC4-type RING-HC finger. : Pssm-ID: 438404 Cd Length: 48 Bit Score: 80.94 E-value: 1.07e-20
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Name | Accession | Description | Interval | E-value | ||
RING-HC_RNF212 | cd16746 | RING finger, HC subclass, found in RING finger protein 212 (RNF212) and similar proteins; ... |
4-50 | 1.07e-20 | ||
RING finger, HC subclass, found in RING finger protein 212 (RNF212) and similar proteins; RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis. It plays a central role in designating crossover sites and coupling chromosome synapsis to the formation of crossover-specific recombination complexes. It also functions as an E3 ligase for SUMO modification. RNF212 contains an N-terminal C3HC4-type RING-HC finger. Pssm-ID: 438404 Cd Length: 48 Bit Score: 80.94 E-value: 1.07e-20
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zf-RING_5 | pfam14634 | zinc-RING finger domain; |
6-46 | 2.16e-07 | ||
zinc-RING finger domain; Pssm-ID: 434085 [Multi-domain] Cd Length: 43 Bit Score: 45.88 E-value: 2.16e-07
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COG5236 | COG5236 | Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]; |
10-62 | 3.48e-03 | ||
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]; Pssm-ID: 227561 [Multi-domain] Cd Length: 493 Bit Score: 37.69 E-value: 3.48e-03
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Name | Accession | Description | Interval | E-value | ||
RING-HC_RNF212 | cd16746 | RING finger, HC subclass, found in RING finger protein 212 (RNF212) and similar proteins; ... |
4-50 | 1.07e-20 | ||
RING finger, HC subclass, found in RING finger protein 212 (RNF212) and similar proteins; RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis. It plays a central role in designating crossover sites and coupling chromosome synapsis to the formation of crossover-specific recombination complexes. It also functions as an E3 ligase for SUMO modification. RNF212 contains an N-terminal C3HC4-type RING-HC finger. Pssm-ID: 438404 Cd Length: 48 Bit Score: 80.94 E-value: 1.07e-20
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RING-HC_RNF212-like | cd16560 | RING finger, HC subclass, found in RING finger proteins RNF212, RNF212B and similar proteins; ... |
5-46 | 1.87e-16 | ||
RING finger, HC subclass, found in RING finger proteins RNF212, RNF212B and similar proteins; This subfamily includes RING finger protein RNF212, RNF212B, and their homologs. RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis. It plays a central role in designating crossover sites and coupling chromosome synapsis to the formation of crossover-specific recombination complexes. It also functions as an E3 ligase for small ubiquitin-related modifier (SUMO) modification. RNF212B shows high sequence similarity with RNF212, but its biological function remains unclear. Members of this subfamily contain an N-terminal C3HC4-type RING-HC finger. Also included are two homologs of RNF212, meiotic procrossover factors Zip3 and ZHP-3, which have been identified in Saccharomyces cerevisiae and Caenorhabditis elegans, respectively. Budding yeast Zip3 is a small ubiquitin-related modifier (SUMO) E3 ligase implicated in the SUMO pathway of post-translational modification. It sumoylates chromosome axis proteins, thus promoting synaptonemal complex polymerization. It also acts as an Smt3 E3 ligase. Zip3 includes a SUMO Interacting Motif (SIM) and a modified C3HCHC2-type RING-HC finger that are important for Zip3 in vitro E3 ligase activity and necessary for SC polymerization and correct sporulation. ZHP-3 acts at crossovers to couple meiotic recombination with synaptonemal complex disassembly and chiasma formation in Caenorhabditis elegans. It possesses a C3HC4-type RING-HC finger. Pssm-ID: 438222 Cd Length: 42 Bit Score: 69.88 E-value: 1.87e-16
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zf-RING_5 | pfam14634 | zinc-RING finger domain; |
6-46 | 2.16e-07 | ||
zinc-RING finger domain; Pssm-ID: 434085 [Multi-domain] Cd Length: 43 Bit Score: 45.88 E-value: 2.16e-07
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RING-HC_RNF212B | cd16747 | RING finger, HC subclass, found in RING finger protein 212B (RNF212B) and similar proteins; ... |
7-46 | 1.35e-03 | ||
RING finger, HC subclass, found in RING finger protein 212B (RNF212B) and similar proteins; RNF212B is an uncharacterized protein with high sequence similarity with RNF212, a dosage-sensitive regulator of crossing-over during mammalian meiosis. RNF212B contains an N-terminal C3HC4-type RING-HC finger. Pssm-ID: 438405 Cd Length: 37 Bit Score: 35.46 E-value: 1.35e-03
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RING-HC_BARD1 | cd16496 | RING finger, HC subclass, found in BRCA1-associated RING domain protein 1 (BARD-1) and similar ... |
7-78 | 1.80e-03 | ||
RING finger, HC subclass, found in BRCA1-associated RING domain protein 1 (BARD-1) and similar proteins; BARD-1 is a critical factor in BRCA1-mediated tumor suppression and may also serve as a target for tumorigenic lesions in some human cancers. It associates with BRCA1 (breast cancer-1) to form a heterodimeric BRCA1/BARD1 complex that is responsible for maintaining genomic stability through nuclear functions involving DNA damage signaling and repair, transcriptional regulation, and cell cycle control. The BRCA1/BARD1 complex catalyzes autoubiquitination of BRCA1 and trans ubiquitination of other protein substrates. Its E3 ligase activity is dramatically reduced in the presence of UBX domain protein 1 (UBXN1). BARD-1 contains an C3HC4-type RING-HC finger that binds BRCA1 at its N-terminus and three tandem ankyrin repeats and tandem BRCT repeat domains at its C-terminus. The BRCT repeats bind CstF-50 (cleavage stimulation factor) to modulate mRNA processing and RNAP II stability in response to DNA damage. Pssm-ID: 438159 [Multi-domain] Cd Length: 86 Bit Score: 36.16 E-value: 1.80e-03
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COG5236 | COG5236 | Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]; |
10-62 | 3.48e-03 | ||
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]; Pssm-ID: 227561 [Multi-domain] Cd Length: 493 Bit Score: 37.69 E-value: 3.48e-03
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