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Conserved domains on  [gi|767930405|ref|XP_011512027|]
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WD repeat-containing protein 19 isoform X2 [Homo sapiens]

Protein Classification

WD40 and WD40_3 domain-containing protein( domain architecture ID 11456978)

WD40 and WD40_3 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40_3 pfam15911
WD domain, G-beta repeat;
486-542 5.15e-30

WD domain, G-beta repeat;


:

Pssm-ID: 464937  Cd Length: 57  Bit Score: 113.07  E-value: 5.15e-30
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767930405   486 VNDYRHPVSVKKIFPDPNGTRLVFIDEKSDGFVYCPVNDATYEIPDFSPTIKGVLWE 542
Cdd:pfam15911    1 VNEYRHSVGIKKLFPNPSGTRLVFIDEKGDGFLYNPVSDELLEIPDFPPTVKGVLWD 57
WD40 COG2319
WD40 repeat [General function prediction only];
21-323 4.35e-10

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.39  E-value: 4.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405   21 WQKTSGNYLAV----TGNCVAMDWDKDGDVLAVIAEKSScIYLWDANTNKTSQLDNGMRDQMSFLLWSKVGSFLAVGTVK 96
Cdd:COG2319   105 WDLATGLLLRTltghTGAVRSVAFSPDGKTLASGSADGT-VRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDD 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405   97 GNLLIYNHQTSRKIPVLGKHTKRITCGCWNAE-NLLALGGEDKMITVSN-QEGDTIRQTQVRSEPSNmqfflmkmddrtS 174
Cdd:COG2319   184 GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgKLLASGSADGTVRLWDlATGKLLRTLTGHSGSVR------------S 251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405  175 AAES----MISVVLGKKTLFFLNLNEPDNPADLEFQQDFGNIVCynWYGDGRIMIGFSCGHFV-VISTHTGELGQEIfqa 249
Cdd:COG2319   252 VAFSpdgrLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVA--FSPDGKLLASGSDDGTVrLWDLATGKLLRTL--- 326

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767930405  250 RNHKDNLTSIAVSQTLNKVATCG-DNCIKiqdLVDLKDMYVILNLDEENKGLGTLSWTDDGQLLALSTQRGSLHV 323
Cdd:COG2319   327 TGHTGAVRSVAFSPDGKTLASGSdDGTVR---LWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 764-982 5.51e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.81  E-value: 5.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405  764 AIQLEFAGDYVNALAHYEKGITGDNkEHDEACLAgVAQMSIRMGDIRRGV---NQALK-HPSRV-LKRDCGAILENMKQF 838
Cdd:COG2956    15 GLNYLLNGQPDKAIDLLEEALELDP-ETVEAHLA-LGNLYRRRGEYDRAIrihQKLLErDPDRAeALLELAQDYLKAGLL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405  839 SEAAQLYEKGL--------YYDKAASVYIRSKNWAKVGDLL-----PHVSSPKIHLQYAKAKEADGRYKEAVVAYENA-- 903
Cdd:COG2956    93 DRAEELLEKLLeldpddaeALRLLAEIYEQEGDWEKAIEVLerllkLGPENAHAYCELAELYLEQGDYDEAIEALEKAlk 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405  904 KQWQSV------IRIYLDHlNNPEKAVNIVRET-----QSLDGAKMVARFFLQLGDYGSAIQFLvmskcnNEAFTLAQQH 972
Cdd:COG2956   173 LDPDCArallllAELYLEQ-GDYEEAIAALERAleqdpDYLPALPRLAELYEKLGDPEEALELL------RKALELDPSD 245

                         250
                  ....*....|
gi 767930405  973 NKMEIYADII 982
Cdd:COG2956   246 DLLLALADLL 255
 
Name Accession Description Interval E-value
WD40_3 pfam15911
WD domain, G-beta repeat;
486-542 5.15e-30

WD domain, G-beta repeat;


Pssm-ID: 464937  Cd Length: 57  Bit Score: 113.07  E-value: 5.15e-30
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767930405   486 VNDYRHPVSVKKIFPDPNGTRLVFIDEKSDGFVYCPVNDATYEIPDFSPTIKGVLWE 542
Cdd:pfam15911    1 VNEYRHSVGIKKLFPNPSGTRLVFIDEKGDGFLYNPVSDELLEIPDFPPTVKGVLWD 57
WD40 COG2319
WD40 repeat [General function prediction only];
21-323 4.35e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.39  E-value: 4.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405   21 WQKTSGNYLAV----TGNCVAMDWDKDGDVLAVIAEKSScIYLWDANTNKTSQLDNGMRDQMSFLLWSKVGSFLAVGTVK 96
Cdd:COG2319   105 WDLATGLLLRTltghTGAVRSVAFSPDGKTLASGSADGT-VRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDD 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405   97 GNLLIYNHQTSRKIPVLGKHTKRITCGCWNAE-NLLALGGEDKMITVSN-QEGDTIRQTQVRSEPSNmqfflmkmddrtS 174
Cdd:COG2319   184 GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgKLLASGSADGTVRLWDlATGKLLRTLTGHSGSVR------------S 251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405  175 AAES----MISVVLGKKTLFFLNLNEPDNPADLEFQQDFGNIVCynWYGDGRIMIGFSCGHFV-VISTHTGELGQEIfqa 249
Cdd:COG2319   252 VAFSpdgrLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVA--FSPDGKLLASGSDDGTVrLWDLATGKLLRTL--- 326

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767930405  250 RNHKDNLTSIAVSQTLNKVATCG-DNCIKiqdLVDLKDMYVILNLDEENKGLGTLSWTDDGQLLALSTQRGSLHV 323
Cdd:COG2319   327 TGHTGAVRSVAFSPDGKTLASGSdDGTVR---LWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 32-324 4.32e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.27  E-value: 4.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405   32 TGNCVAMDWDKDGDVLAVIAEkSSCIYLWDANTNKTSQLDNGMRDQMSFLLWSKVGSFLAVGTVKGNLLIYNHQTSRKIP 111
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSG-DGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405  112 VLGKHTKRITCGCWNAEN-LLALGGEDKmitvsnqegdTIRqtqvrsepsnmqfflmkmddrtsaaesmisvvlgkktlf 190
Cdd:cd00200    88 TLTGHTSYVSSVAFSPDGrILSSSSRDK----------TIK--------------------------------------- 118

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405  191 FLNLNEPDNPADLEFQQDFGNIVCYNwyGDGRIMIGFSCGHFV-VISTHTGELGQEIfqaRNHKDNLTSIAVSQTLNKVA 269
Cdd:cd00200   119 VWDVETGKCLTTLRGHTDWVNSVAFS--PDGTFVASSSQDGTIkLWDLRTGKCVATL---TGHTGEVNSVAFSPDGEKLL 193

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767930405  270 TCG-DNCIKIQDLVDLKDMYVilnLDEENKGLGTLSWTDDGQLLALSTQRGSLHVF 324
Cdd:cd00200   194 SSSsDGTIKLWDLSTGKCLGT---LRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 764-982 5.51e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.81  E-value: 5.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405  764 AIQLEFAGDYVNALAHYEKGITGDNkEHDEACLAgVAQMSIRMGDIRRGV---NQALK-HPSRV-LKRDCGAILENMKQF 838
Cdd:COG2956    15 GLNYLLNGQPDKAIDLLEEALELDP-ETVEAHLA-LGNLYRRRGEYDRAIrihQKLLErDPDRAeALLELAQDYLKAGLL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405  839 SEAAQLYEKGL--------YYDKAASVYIRSKNWAKVGDLL-----PHVSSPKIHLQYAKAKEADGRYKEAVVAYENA-- 903
Cdd:COG2956    93 DRAEELLEKLLeldpddaeALRLLAEIYEQEGDWEKAIEVLerllkLGPENAHAYCELAELYLEQGDYDEAIEALEKAlk 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405  904 KQWQSV------IRIYLDHlNNPEKAVNIVRET-----QSLDGAKMVARFFLQLGDYGSAIQFLvmskcnNEAFTLAQQH 972
Cdd:COG2956   173 LDPDCArallllAELYLEQ-GDYEEAIAALERAleqdpDYLPALPRLAELYEKLGDPEEALELL------RKALELDPSD 245

                         250
                  ....*....|
gi 767930405  973 NKMEIYADII 982
Cdd:COG2956   246 DLLLALADLL 255
CLH smart00299
Clathrin heavy chain repeat homology;
833-946 1.15e-03

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 40.72  E-value: 1.15e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405    833 ENMKQFSEAAQLYekgLYYDKAASV-YIRSKNwakvgdllPHVSSPKIhlqYAKAKEADGrYKEAVVAYENAKQWQSVIR 911
Cdd:smart00299   39 ENPALQTKLIELY---AKYDPQKEIeRLDNKS--------NHYDIEKV---GKLCEKAKL-YEEAVELYKKDGNFKDAIV 103

                            90       100       110
                    ....*....|....*....|....*....|....*
gi 767930405    912 IYLDHLNNPEKAVNIVRETQSLDGAKMVARFFLQL 946
Cdd:smart00299  104 TLIEHLGNYEKAIEYFVKQNNPELWAEVLKALLDK 138
 
Name Accession Description Interval E-value
WD40_3 pfam15911
WD domain, G-beta repeat;
486-542 5.15e-30

WD domain, G-beta repeat;


Pssm-ID: 464937  Cd Length: 57  Bit Score: 113.07  E-value: 5.15e-30
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767930405   486 VNDYRHPVSVKKIFPDPNGTRLVFIDEKSDGFVYCPVNDATYEIPDFSPTIKGVLWE 542
Cdd:pfam15911    1 VNEYRHSVGIKKLFPNPSGTRLVFIDEKGDGFLYNPVSDELLEIPDFPPTVKGVLWD 57
WD40 COG2319
WD40 repeat [General function prediction only];
21-323 4.35e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.39  E-value: 4.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405   21 WQKTSGNYLAV----TGNCVAMDWDKDGDVLAVIAEKSScIYLWDANTNKTSQLDNGMRDQMSFLLWSKVGSFLAVGTVK 96
Cdd:COG2319   105 WDLATGLLLRTltghTGAVRSVAFSPDGKTLASGSADGT-VRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDD 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405   97 GNLLIYNHQTSRKIPVLGKHTKRITCGCWNAE-NLLALGGEDKMITVSN-QEGDTIRQTQVRSEPSNmqfflmkmddrtS 174
Cdd:COG2319   184 GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgKLLASGSADGTVRLWDlATGKLLRTLTGHSGSVR------------S 251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405  175 AAES----MISVVLGKKTLFFLNLNEPDNPADLEFQQDFGNIVCynWYGDGRIMIGFSCGHFV-VISTHTGELGQEIfqa 249
Cdd:COG2319   252 VAFSpdgrLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVA--FSPDGKLLASGSDDGTVrLWDLATGKLLRTL--- 326

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767930405  250 RNHKDNLTSIAVSQTLNKVATCG-DNCIKiqdLVDLKDMYVILNLDEENKGLGTLSWTDDGQLLALSTQRGSLHV 323
Cdd:COG2319   327 TGHTGAVRSVAFSPDGKTLASGSdDGTVR---LWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 32-324 4.32e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.27  E-value: 4.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405   32 TGNCVAMDWDKDGDVLAVIAEkSSCIYLWDANTNKTSQLDNGMRDQMSFLLWSKVGSFLAVGTVKGNLLIYNHQTSRKIP 111
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSG-DGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405  112 VLGKHTKRITCGCWNAEN-LLALGGEDKmitvsnqegdTIRqtqvrsepsnmqfflmkmddrtsaaesmisvvlgkktlf 190
Cdd:cd00200    88 TLTGHTSYVSSVAFSPDGrILSSSSRDK----------TIK--------------------------------------- 118

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405  191 FLNLNEPDNPADLEFQQDFGNIVCYNwyGDGRIMIGFSCGHFV-VISTHTGELGQEIfqaRNHKDNLTSIAVSQTLNKVA 269
Cdd:cd00200   119 VWDVETGKCLTTLRGHTDWVNSVAFS--PDGTFVASSSQDGTIkLWDLRTGKCVATL---TGHTGEVNSVAFSPDGEKLL 193

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767930405  270 TCG-DNCIKIQDLVDLKDMYVilnLDEENKGLGTLSWTDDGQLLALSTQRGSLHVF 324
Cdd:cd00200   194 SSSsDGTIKLWDLSTGKCLGT---LRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 32-140 1.10e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.03  E-value: 1.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405   32 TGNCVAMDWDKDGDVLAVIAEkSSCIYLWDANTNKTSQLDNGMRDQMSFLLWSKVGSFLAVGTVKGNLLIYNHQTSRKIP 111
Cdd:cd00200   177 TGEVNSVAFSPDGEKLLSSSS-DGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQ 255

                          90       100       110
                  ....*....|....*....|....*....|
gi 767930405  112 VLGKHTKRITCGCWNAE-NLLALGGEDKMI 140
Cdd:cd00200   256 TLSGHTNSVTSLAWSPDgKRLASGSADGTI 285
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 764-982 5.51e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.81  E-value: 5.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405  764 AIQLEFAGDYVNALAHYEKGITGDNkEHDEACLAgVAQMSIRMGDIRRGV---NQALK-HPSRV-LKRDCGAILENMKQF 838
Cdd:COG2956    15 GLNYLLNGQPDKAIDLLEEALELDP-ETVEAHLA-LGNLYRRRGEYDRAIrihQKLLErDPDRAeALLELAQDYLKAGLL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405  839 SEAAQLYEKGL--------YYDKAASVYIRSKNWAKVGDLL-----PHVSSPKIHLQYAKAKEADGRYKEAVVAYENA-- 903
Cdd:COG2956    93 DRAEELLEKLLeldpddaeALRLLAEIYEQEGDWEKAIEVLerllkLGPENAHAYCELAELYLEQGDYDEAIEALEKAlk 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405  904 KQWQSV------IRIYLDHlNNPEKAVNIVRET-----QSLDGAKMVARFFLQLGDYGSAIQFLvmskcnNEAFTLAQQH 972
Cdd:COG2956   173 LDPDCArallllAELYLEQ-GDYEEAIAALERAleqdpDYLPALPRLAELYEKLGDPEEALELL------RKALELDPSD 245

                         250
                  ....*....|
gi 767930405  973 NKMEIYADII 982
Cdd:COG2956   246 DLLLALADLL 255
WD40 COG2319
WD40 repeat [General function prediction only];
43-323 7.07e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 53.38  E-value: 7.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405   43 DGDVLAVIAEKSScIYLWDANTNKTSQLDNGMRDQMSFLLWSKVGSFLAVGTVKGNLLIYNHQTSRKIPVLGKHTKRITC 122
Cdd:COG2319    89 DGRLLASASADGT-VRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTS 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405  123 GCWNAE-NLLALGGEDKMITV-SNQEGDTIRQTQVRSEP-SNMQFflmkmddrtSAAESMISVVLGKKTLFFLNLNEPDN 199
Cdd:COG2319   168 VAFSPDgKLLASGSDDGTVRLwDLATGKLLRTLTGHTGAvRSVAF---------SPDGKLLASGSADGTVRLWDLATGKL 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405  200 PADLEFQQDFGNIVCYNwyGDGRIMIGFSCGHFV-VISTHTGELGQEIfqaRNHKDNLTSIAVSQTLNKVATCGDNC-IK 277
Cdd:COG2319   239 LRTLTGHSGSVRSVAFS--PDGRLLASGSADGTVrLWDLATGELLRTL---TGHSGGVNSVAFSPDGKLLASGSDDGtVR 313

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 767930405  278 IQDLVDLKdmyVILNLDEENKGLGTLSWTDDGQLLALSTQRGSLHV 323
Cdd:COG2319   314 LWDLATGK---LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRL 356
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 651-903 3.03e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 50.50  E-value: 3.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405  651 NDEAAWNELARACLHHMEVEFAIRVYRRIgnvgivmsLEQIKGIEDYNLLAGHLAMFTNDYNLAQDLY--LASSCP--IA 726
Cdd:COG2956    40 ETVEAHLALGNLYRRRGEYDRAIRIHQKL--------LERDPDRAEALLELAQDYLKAGLLDRAEELLekLLELDPddAE 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405  727 ALEVWQQMRRDLQHWDSALQLAKHLAP--DQIPFISKEYAIQLEFAGDYVNALAHYEKGITgDNKEHDEACLAgVAQMSI 804
Cdd:COG2956   112 ALRLLAEIYEQEGDWEKAIEVLERLLKlgPENAHAYCELAELYLEQGDYDEAIEALEKALK-LDPDCARALLL-LAELYL 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405  805 RMGDirrgVNQALKHPSRVLKRDcgaiLENMKQFSEAAQLYEKGLYYDKAASVYIRsknwakvgdLLPHVSSPKIHLQYA 884
Cdd:COG2956   190 EQGD----YEEAIAALERALEQD----PDYLPALPRLAELYEKLGDPEEALELLRK---------ALELDPSDDLLLALA 252

                         250
                  ....*....|....*....
gi 767930405  885 KAKEADGRYKEAVVAYENA 903
Cdd:COG2956   253 DLLERKEGLEAALALLERQ 271
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 697-945 9.73e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 49.99  E-value: 9.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405  697 YNLLAGHLAMFTNDYNLAQDLYLASSCPIAALEVWQQMRRDLQHWDSALQLAKHLAPDQIPFISKEYAIQLEfAGDYVNA 776
Cdd:COG3914    19 AAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQA-LGRYEEA 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405  777 LAHYEKGITGDNKEHDEACLAGVAQMsiRMGDIrrgvNQALKHPSRVLKRD---------CGAILENMKQFSEAAQLYEK 847
Cdd:COG3914    98 LALYRRALALNPDNAEALFNLGNLLL--ALGRL----EEALAALRRALALNpdfaeaylnLGEALRRLGRLEEAIAALRR 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405  848 GLyydkaasvyirsknwakvgDLLPHvsSPKIHLQYAKAKEADGRYKEAVVAYENAKQ--------WQSVIRIYLDHLNN 919
Cdd:COG3914   172 AL-------------------ELDPD--NAEALNNLGNALQDLGRLEEAIAAYRRALEldpdnadaHSNLLFALRQACDW 230

                         250       260
                  ....*....|....*....|....*.
gi 767930405  920 PEKAVNIVRETQSLDGAKMVARFFLQ 945
Cdd:COG3914   231 EVYDRFEELLAALARGPSELSPFALL 256
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 32-280 1.62e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.49  E-value: 1.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405   32 TGNCVAMDWDKDGDVLAVIAEKSSCIyLWDANTNKTSQLDNGMRDQMSFLLWSKVGSFLAVGTVKGNLLIYNHQTSRKIP 111
Cdd:cd00200    93 TSYVSSVAFSPDGRILSSSSRDKTIK-VWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405  112 VLGKHTKRITCGCWNAEN-LLALGGEDKMITVSN-QEGDTIRQtqvrsepsnmqfflmkmddrtsaaesmisvvlgkktl 189
Cdd:cd00200   172 TLTGHTGEVNSVAFSPDGeKLLSSSSDGTIKLWDlSTGKCLGT------------------------------------- 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405  190 fflnlnepdnpadLEFQQDFgnIVCYNWYGDGRIMIGFSC-GHFVVISTHTGELGQEIfqaRNHKDNLTSIAVSQTLNKV 268
Cdd:cd00200   215 -------------LRGHENG--VNSVAFSPDGYLLASGSEdGTIRVWDLRTGECVQTL---SGHTNSVTSLAWSPDGKRL 276

                         250
                  ....*....|...
gi 767930405  269 ATCG-DNCIKIQD 280
Cdd:cd00200   277 ASGSaDGTIRIWD 289
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 762-905 1.98e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 42.87  E-value: 1.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405  762 EYAIQLEFAGDYVNALAHYEKGITgDNKEHDEAcLAGVAQMSIRMGDIRRGV---NQALK-HP-SRVLKRDCGAILENMK 836
Cdd:COG4783     9 ALAQALLLAGDYDEAEALLEKALE-LDPDNPEA-FALLGEILLQLGDLDEAIvllHEALElDPdEPEARLNLGLALLKAG 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767930405  837 QFSEAAQLYEKGLYYDKaasvyirsknwakvgdllphvSSPKIHLQYAKAKEADGRYKEAVVAYENAKQ 905
Cdd:COG4783    87 DYDEALALLEKALKLDP---------------------EHPEAYLRLARAYRALGRPDEAIAALEKALE 134
COG4700 COG4700
Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];
829-903 2.60e-04

Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];


Pssm-ID: 443735 [Multi-domain]  Cd Length: 249  Bit Score: 44.10  E-value: 2.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405  829 GAILENMKQFSEAAQLYEK---GLYYD------KAASVYIRSKNWAKVGDLL-------PHVSSPKIHLQYAKAKEADGR 892
Cdd:COG4700    96 ADALLELGRYDEAIELYEEaltGIFADdphillGLAQALFELGRYAEALETLekliaknPDFKSSDAHLLYARALEALGD 175

                          90
                  ....*....|.
gi 767930405  893 YKEAVVAYENA 903
Cdd:COG4700   176 LEAAEAELEAL 186
COG5290 COG5290
IkappaB kinase complex, IKAP component [Transcription];
814-912 4.72e-04

IkappaB kinase complex, IKAP component [Transcription];


Pssm-ID: 227610 [Multi-domain]  Cd Length: 1243  Bit Score: 44.61  E-value: 4.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405  814 NQALKHpsrvLKRDCGAILENMKqFSEAAQLYEKGLYYDKaasvYIRSKNWAKVGDLLPHVSSPKIHLQYAKAKEADGRY 893
Cdd:COG5290   881 ESALGH----LNEDLNVIREVMK-YICRHDLYDFLLLLYR----YDGELQKFKINIFAGNLVDNLYHISAAKAYEVEGKY 951

                          90
                  ....*....|....*....
gi 767930405  894 KEAVVAYENAKQWQSVIRI 912
Cdd:COG5290   952 IEAHGAYDSALMWRECGSI 970
CLH smart00299
Clathrin heavy chain repeat homology;
833-946 1.15e-03

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 40.72  E-value: 1.15e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405    833 ENMKQFSEAAQLYekgLYYDKAASV-YIRSKNwakvgdllPHVSSPKIhlqYAKAKEADGrYKEAVVAYENAKQWQSVIR 911
Cdd:smart00299   39 ENPALQTKLIELY---AKYDPQKEIeRLDNKS--------NHYDIEKV---GKLCEKAKL-YEEAVELYKKDGNFKDAIV 103

                            90       100       110
                    ....*....|....*....|....*....|....*
gi 767930405    912 IYLDHLNNPEKAVNIVRETQSLDGAKMVARFFLQL 946
Cdd:smart00299  104 TLIEHLGNYEKAIEYFVKQNNPELWAEVLKALLDK 138
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
771-903 3.79e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 40.76  E-value: 3.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930405  771 GDYVNALAHYEKGITGDNKEHDEACLAGVAQMsiRMGDIRrgvnQALKHPSRVLKRD---------CGAILENMKQFSEA 841
Cdd:COG0457    22 GRYEEAIEDYEKALELDPDDAEALYNLGLAYL--RLGRYE----EALADYEQALELDpddaealnnLGLALQALGRYEEA 95

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767930405  842 AQLYEKGLyydkaasvyirsknwakvgDLLPhvSSPKIHLQYAKAKEADGRYKEAVVAYENA 903
Cdd:COG0457    96 LEDYDKAL-------------------ELDP--DDAEALYNLGLALLELGRYDEAIEAYERA 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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