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Conserved domains on  [gi|767930418|ref|XP_011512033|]
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replication factor C subunit 1 isoform X1 [Homo sapiens]

Protein Classification

AAA and RFC1 domain-containing protein; BRCT_RFC1 and RFC1 domain-containing protein( domain architecture ID 13027101)

protein containing domains BRCT_RFC1, AAA, and RFC1; protein containing domains COG5275, BRCT_RFC1, AAA, and RFC1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RFC1 pfam08519
Replication factor RFC1 C terminal domain; This is the C terminal domain of replication factor ...
 745-898 1.03e-78

Replication factor RFC1 C terminal domain; This is the C terminal domain of replication factor C, RFC1. RFC complexes hydrolyse ATP and load sliding clamps such as PCNA (proliferating cell nuclear antigen) onto double-stranded DNA. RFC1 is essential for RFC function in vivo.


:

Pssm-ID: 462507  Cd Length: 158  Bit Score: 253.27  E-value: 1.03e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418  745 ICDGDLVDSQIRSKQNWSLLPAQAIYASVLPGELMRGYMTQFPTFPSWLGKHSSTGKHDRIVQDLALHMSLRTYSSKRTV 824
Cdd:pfam08519   1 ISDGDLVDRMIRGEQQWSLLPTHAVFSSVRPASFMRGSMTGRINFPSWLGKNSKTGKNKRLLQELQYHMRLKTSGDKSEL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767930418  825 NMDYLSLLRDALVQPLTSQGVDGVQDVVALMDTYYLMKEDFENIMEISSWG----GKPSPFSKLDPKVKAAFTRAYNK 898
Cdd:pfam08519  81 RLDYLPLLRKRLTQPLLEEGKDGVDEVIDLMDEYYLTKEDWDNIVELSTWGvgpyGEEDPLKKIDTKVKAAFTRKYNK 158
BRCT_RFC1 cd17752
BRCT domain of replication factor C subunit 1 (RFC1) and similar proteins; RFC1, also termed ...
 402-480 3.59e-46

BRCT domain of replication factor C subunit 1 (RFC1) and similar proteins; RFC1, also termed activator 1 140 kDa subunit, or A1 140 kDa subunit, or activator 1 large subunit, or activator 1 subunit 1, or replication factor C 140 kDa subunit, or RF-C 140 kDa subunit, or RFC140, is the large subunit of replication factor C (RFC), which is a heteropentameric protein essential for DNA replication and repair. RFC1 can bind single- or double-stranded DNA. It could play a role in DNA transcription regulation as well as DNA replication and/or repair. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this family.


:

Pssm-ID: 349383 [Multi-domain]  Cd Length: 79  Bit Score: 159.69  E-value: 3.59e-46
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767930418 402 GAENCLEGLIFVITGVLESIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAAALGTKIIDEDGLLNLIR 480
Cdd:cd17752    1 GAPNCLEGLTFVITGVLESLEREEAEDLIKRYGGKVTGSVSKKTSYLVVGRDAGPSKLEKAKELGTKIIDEDGLFDLIR 79
PRK04195 super family cl35251
replication factor C large subunit; Provisional
 497-833 2.77e-34

replication factor C large subunit; Provisional


The actual alignment was detected with superfamily member PRK04195:

Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 138.13  E-value: 2.77e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418 497 ELGYSYVELNASDTRSKSSLKAIVAESLNNTSIKGFysngaassvstKHALI-MDEVDGMAGNEDRGGIQELIGLIKHTK 575
Cdd:PRK04195  62 DYGWEVIELNASDQRTADVIERVAGEAATSGSLFGA-----------RRKLIlLDEVDGIHGNEDRGGARAILELIKKAK 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418 576 IPIICMCNDRNHPKIRSLVHYCFDLRFQRPRVEQIKGAMMSIAFKEGLKIPPPAMNEIILGANQDIRQVLHNLSMWCARS 655
Cdd:PRK04195 131 QPIILTANDPYDPSLRELRNACLMIEFKRLSTRSIVPVLKRICRKEGIECDDEALKEIAERSGGDLRSAINDLQAIAEGY 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418 656 KALTYDQAKAdshRAKKDIKMGPFDVARKVFA---AGEETAHMSLVDKS-DLFFHdysiaplFVQEN----YIHVKPVAA 727
Cdd:PRK04195 211 GKLTLEDVKT---LGRRDREESIFDALDAVFKarnADQALEASYDVDEDpDDLIE-------WIDENipkeYDDPEDIAR 280

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418 728 GGDMkkhlmlLSRAadsicdgDLVDSQIRSKQNWSLLPaqaiYASvlpgELM------------RGYmTQFpTFPSWLGK 795
Cdd:PRK04195 281 AYDA------LSRA-------DIFLGRVKRTQNYDLWR----YAS----DLMtagvalakekkkRGF-TRY-QPPSYWRL 337

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 767930418 796 HSSTGKHDRIVQDLALHMSLRTYSSKRTVNMDYLSLLR 833
Cdd:PRK04195 338 LSKTKEKRETRDSIAKKIAEKLHTSKRKVRREVLPFLS 375
PTZ00121 super family cl31754
MAEBL; Provisional
 14-404 1.02e-08

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 59.77  E-value: 1.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418   14 KKLVSETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDSESEETLQVKNAKKPPEKLP--- 90
Cdd:PTZ00121 1328 KKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKkka 1407

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418   91 --VSSKPGKISRQDPVTYISETDEEDDFMCKKA--ASKSKENGRSTNSHLGTSNMKKNEENTKTKNKplSPIKLTPTSVL 166
Cdd:PTZ00121 1408 deLKKAAAAKKKADEAKKKAEEKKKADEAKKKAeeAKKADEAKKKAEEAKKAEEAKKKAEEAKKADE--AKKKAEEAKKA 1485

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418  167 DYFGTGSVQRSNKKMVASKRKELSQNTDESGLNDEA-IAKQLQLDEDAELERQLHEDEEF--ARTLAMLDEEPKTKKARK 243
Cdd:PTZ00121 1486 DEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAkKADEAKKAEEAKKADEAKKAEEKkkADELKKAEELKKAEEKKK 1565

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418  244 DTEAGETFSSVQANLSKAEKHKyphKVKTAQVSDERKSYSPRKQSKYESSKESQQhSKSSADKIGEVSSPKasSKLAIMK 323
Cdd:PTZ00121 1566 AEEAKKAEEDKNMALRKAEEAK---KAEEARIEEVMKLYEEEKKMKAEEAKKAEE-AKIKAEELKKAEEEK--KKVEQLK 1639

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418  324 RKEESSYKEIEPVASKRKENAIKLKGETKTPKKTKSspaKKESVSPEDSEKKRTNYQayrsyLNREGPKALGSKEIPKGA 403
Cdd:PTZ00121 1640 KKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKK---KAEEAKKAEEDEKKAAEA-----LKKEAEEAKKAEELKKKE 1711


                  .
gi 767930418  404 E 404
Cdd:PTZ00121 1712 A 1712
 
Name Accession Description Interval E-value
RFC1 pfam08519
Replication factor RFC1 C terminal domain; This is the C terminal domain of replication factor ...
 745-898 1.03e-78

Replication factor RFC1 C terminal domain; This is the C terminal domain of replication factor C, RFC1. RFC complexes hydrolyse ATP and load sliding clamps such as PCNA (proliferating cell nuclear antigen) onto double-stranded DNA. RFC1 is essential for RFC function in vivo.


Pssm-ID: 462507  Cd Length: 158  Bit Score: 253.27  E-value: 1.03e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418  745 ICDGDLVDSQIRSKQNWSLLPAQAIYASVLPGELMRGYMTQFPTFPSWLGKHSSTGKHDRIVQDLALHMSLRTYSSKRTV 824
Cdd:pfam08519   1 ISDGDLVDRMIRGEQQWSLLPTHAVFSSVRPASFMRGSMTGRINFPSWLGKNSKTGKNKRLLQELQYHMRLKTSGDKSEL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767930418  825 NMDYLSLLRDALVQPLTSQGVDGVQDVVALMDTYYLMKEDFENIMEISSWG----GKPSPFSKLDPKVKAAFTRAYNK 898
Cdd:pfam08519  81 RLDYLPLLRKRLTQPLLEEGKDGVDEVIDLMDEYYLTKEDWDNIVELSTWGvgpyGEEDPLKKIDTKVKAAFTRKYNK 158
BRCT_RFC1 cd17752
BRCT domain of replication factor C subunit 1 (RFC1) and similar proteins; RFC1, also termed ...
 402-480 3.59e-46

BRCT domain of replication factor C subunit 1 (RFC1) and similar proteins; RFC1, also termed activator 1 140 kDa subunit, or A1 140 kDa subunit, or activator 1 large subunit, or activator 1 subunit 1, or replication factor C 140 kDa subunit, or RF-C 140 kDa subunit, or RFC140, is the large subunit of replication factor C (RFC), which is a heteropentameric protein essential for DNA replication and repair. RFC1 can bind single- or double-stranded DNA. It could play a role in DNA transcription regulation as well as DNA replication and/or repair. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this family.


Pssm-ID: 349383 [Multi-domain]  Cd Length: 79  Bit Score: 159.69  E-value: 3.59e-46
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767930418 402 GAENCLEGLIFVITGVLESIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAAALGTKIIDEDGLLNLIR 480
Cdd:cd17752    1 GAPNCLEGLTFVITGVLESLEREEAEDLIKRYGGKVTGSVSKKTSYLVVGRDAGPSKLEKAKELGTKIIDEDGLFDLIR 79
PRK04195 PRK04195
replication factor C large subunit; Provisional
 497-833 2.77e-34

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 138.13  E-value: 2.77e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418 497 ELGYSYVELNASDTRSKSSLKAIVAESLNNTSIKGFysngaassvstKHALI-MDEVDGMAGNEDRGGIQELIGLIKHTK 575
Cdd:PRK04195  62 DYGWEVIELNASDQRTADVIERVAGEAATSGSLFGA-----------RRKLIlLDEVDGIHGNEDRGGARAILELIKKAK 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418 576 IPIICMCNDRNHPKIRSLVHYCFDLRFQRPRVEQIKGAMMSIAFKEGLKIPPPAMNEIILGANQDIRQVLHNLSMWCARS 655
Cdd:PRK04195 131 QPIILTANDPYDPSLRELRNACLMIEFKRLSTRSIVPVLKRICRKEGIECDDEALKEIAERSGGDLRSAINDLQAIAEGY 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418 656 KALTYDQAKAdshRAKKDIKMGPFDVARKVFA---AGEETAHMSLVDKS-DLFFHdysiaplFVQEN----YIHVKPVAA 727
Cdd:PRK04195 211 GKLTLEDVKT---LGRRDREESIFDALDAVFKarnADQALEASYDVDEDpDDLIE-------WIDENipkeYDDPEDIAR 280

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418 728 GGDMkkhlmlLSRAadsicdgDLVDSQIRSKQNWSLLPaqaiYASvlpgELM------------RGYmTQFpTFPSWLGK 795
Cdd:PRK04195 281 AYDA------LSRA-------DIFLGRVKRTQNYDLWR----YAS----DLMtagvalakekkkRGF-TRY-QPPSYWRL 337

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 767930418 796 HSSTGKHDRIVQDLALHMSLRTYSSKRTVNMDYLSLLR 833
Cdd:PRK04195 338 LSKTKEKRETRDSIAKKIAEKLHTSKRKVRREVLPFLS 375
Lig COG0272
NAD-dependent DNA ligase [Replication, recombination and repair];
398-479 8.48e-28

NAD-dependent DNA ligase [Replication, recombination and repair];


Pssm-ID: 440042 [Multi-domain]  Cd Length: 668  Bit Score: 120.13  E-value: 8.48e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418 398 EIPKGAENCLEGLIFVITGVLESIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGqSKSDKAAALGTKIIDEDGLLN 477
Cdd:COG0272  587 EAEAAADSPLAGKTFVLTGTLETMTRDEAKELIEALGGKVSGSVSKKTDYVVAGENAG-SKLDKAEELGVPILDEAEFLE 665


                 ..
gi 767930418 478 LI 479
Cdd:COG0272  666 LL 667
ligA PRK07956
NAD-dependent DNA ligase LigA; Validated
 392-479 1.71e-25

NAD-dependent DNA ligase LigA; Validated


Pssm-ID: 236137 [Multi-domain]  Cd Length: 665  Bit Score: 112.91  E-value: 1.71e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418 392 KALGSKEIPKGAENCLEGLIFVITGVLESIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGqSKSDKAAALGTKIID 471
Cdd:PRK07956 576 LEAGVNMEYKGEEVDLAGKTVVLTGTLEQLSRDEAKEKLEALGAKVSGSVSKKTDLVVAGEAAG-SKLAKAQELGIEVLD 654


                 ....*...
gi 767930418 472 EDGLLNLI 479
Cdd:PRK07956 655 EEEFLRLL 662
BRCT pfam00533
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ...
 404-479 3.84e-15

BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.


Pssm-ID: 425736 [Multi-domain]  Cd Length: 75  Bit Score: 71.17  E-value: 3.84e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767930418  404 ENCLEGLIFVITGvLESIERDEAKSLIERYGGKVTGNVSKKTNYLVMgrDSGQSKSDKAAALGTKIIDEDGLLNLI 479
Cdd:pfam00533   3 EKLFSGKTFVITG-LDGLERDELKELIEKLGGKVTDSLSKKTTHVIV--EARTKKYLKAKELGIPIVTEEWLLDCI 75
BRCT smart00292
breast cancer carboxy-terminal domain;
404-479 1.95e-13

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 66.24  E-value: 1.95e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767930418   404 ENCLEGLIFVITGVLESIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAAA--LGTKIIDEDGLLNLI 479
Cdd:smart00292   1 PKLFKGKTFYITGSFDKEERDELKELIEALGGKVTSSLSSKTTTHVIVGSPEGGKLELLKAiaLGIPIVKEEWLLDCL 78
HLD_clamp_RFC cd18140
helical lid domain of replication factor C subunit; Replication factor C (RFC) is five-protein ...
 605-661 2.60e-10

helical lid domain of replication factor C subunit; Replication factor C (RFC) is five-protein clamp loader complex that forms a stable ATP-dependent complex with the sliding clamp, PCNA, which binds specifically to primed DNA. RFC subunits belong to the clamp loader clade of the AAA+ superfamily.


Pssm-ID: 350842 [Multi-domain]  Cd Length: 63  Bit Score: 56.77  E-value: 2.60e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767930418 605 PRVEQIKGAMMSIAFKEGLKIPPPAMNEIILGANQDIRQVLHNLSMWCARSKALTYD 661
Cdd:cd18140    1 LSKEQIVKRLREICKKEGVKIDEEALEAIAEKSEGDMRKAINDLQAAAAGGGVITEE 57
PTZ00121 PTZ00121
MAEBL; Provisional
 14-404 1.02e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 59.77  E-value: 1.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418   14 KKLVSETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDSESEETLQVKNAKKPPEKLP--- 90
Cdd:PTZ00121 1328 KKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKkka 1407

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418   91 --VSSKPGKISRQDPVTYISETDEEDDFMCKKA--ASKSKENGRSTNSHLGTSNMKKNEENTKTKNKplSPIKLTPTSVL 166
Cdd:PTZ00121 1408 deLKKAAAAKKKADEAKKKAEEKKKADEAKKKAeeAKKADEAKKKAEEAKKAEEAKKKAEEAKKADE--AKKKAEEAKKA 1485

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418  167 DYFGTGSVQRSNKKMVASKRKELSQNTDESGLNDEA-IAKQLQLDEDAELERQLHEDEEF--ARTLAMLDEEPKTKKARK 243
Cdd:PTZ00121 1486 DEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAkKADEAKKAEEAKKADEAKKAEEKkkADELKKAEELKKAEEKKK 1565

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418  244 DTEAGETFSSVQANLSKAEKHKyphKVKTAQVSDERKSYSPRKQSKYESSKESQQhSKSSADKIGEVSSPKasSKLAIMK 323
Cdd:PTZ00121 1566 AEEAKKAEEDKNMALRKAEEAK---KAEEARIEEVMKLYEEEKKMKAEEAKKAEE-AKIKAEELKKAEEEK--KKVEQLK 1639

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418  324 RKEESSYKEIEPVASKRKENAIKLKGETKTPKKTKSspaKKESVSPEDSEKKRTNYQayrsyLNREGPKALGSKEIPKGA 403
Cdd:PTZ00121 1640 KKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKK---KAEEAKKAEEDEKKAAEA-----LKKEAEEAKKAEELKKKE 1711


                  .
gi 767930418  404 E 404
Cdd:PTZ00121 1712 A 1712
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 497-606 3.13e-04

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 41.81  E-value: 3.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418  497 ELGYSYVELNASDTRSKsslkaIVAESLNNtsIKGFYSNgaASSVStKHALIMDEVDGMAGNEDRGGIQELIGLI----- 571
Cdd:pfam00004  21 ELGAPFIEISGSELVSK-----YVGESEKR--LRELFEA--AKKLA-PCVIFIDEIDALAGSRGSGGDSESRRVVnqllt 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 767930418  572 -------KHTKIPIICMCNdrNHPKIRSLVHYCFDLRFQRPR 606
Cdd:pfam00004  91 eldgftsSNSKVIVIAATN--RPDKLDPALLGRFDRIIEFPL 130
 
Name Accession Description Interval E-value
RFC1 pfam08519
Replication factor RFC1 C terminal domain; This is the C terminal domain of replication factor ...
 745-898 1.03e-78

Replication factor RFC1 C terminal domain; This is the C terminal domain of replication factor C, RFC1. RFC complexes hydrolyse ATP and load sliding clamps such as PCNA (proliferating cell nuclear antigen) onto double-stranded DNA. RFC1 is essential for RFC function in vivo.


Pssm-ID: 462507  Cd Length: 158  Bit Score: 253.27  E-value: 1.03e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418  745 ICDGDLVDSQIRSKQNWSLLPAQAIYASVLPGELMRGYMTQFPTFPSWLGKHSSTGKHDRIVQDLALHMSLRTYSSKRTV 824
Cdd:pfam08519   1 ISDGDLVDRMIRGEQQWSLLPTHAVFSSVRPASFMRGSMTGRINFPSWLGKNSKTGKNKRLLQELQYHMRLKTSGDKSEL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767930418  825 NMDYLSLLRDALVQPLTSQGVDGVQDVVALMDTYYLMKEDFENIMEISSWG----GKPSPFSKLDPKVKAAFTRAYNK 898
Cdd:pfam08519  81 RLDYLPLLRKRLTQPLLEEGKDGVDEVIDLMDEYYLTKEDWDNIVELSTWGvgpyGEEDPLKKIDTKVKAAFTRKYNK 158
BRCT_RFC1 cd17752
BRCT domain of replication factor C subunit 1 (RFC1) and similar proteins; RFC1, also termed ...
 402-480 3.59e-46

BRCT domain of replication factor C subunit 1 (RFC1) and similar proteins; RFC1, also termed activator 1 140 kDa subunit, or A1 140 kDa subunit, or activator 1 large subunit, or activator 1 subunit 1, or replication factor C 140 kDa subunit, or RF-C 140 kDa subunit, or RFC140, is the large subunit of replication factor C (RFC), which is a heteropentameric protein essential for DNA replication and repair. RFC1 can bind single- or double-stranded DNA. It could play a role in DNA transcription regulation as well as DNA replication and/or repair. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this family.


Pssm-ID: 349383 [Multi-domain]  Cd Length: 79  Bit Score: 159.69  E-value: 3.59e-46
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767930418 402 GAENCLEGLIFVITGVLESIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAAALGTKIIDEDGLLNLIR 480
Cdd:cd17752    1 GAPNCLEGLTFVITGVLESLEREEAEDLIKRYGGKVTGSVSKKTSYLVVGRDAGPSKLEKAKELGTKIIDEDGLFDLIR 79
PRK04195 PRK04195
replication factor C large subunit; Provisional
 497-833 2.77e-34

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 138.13  E-value: 2.77e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418 497 ELGYSYVELNASDTRSKSSLKAIVAESLNNTSIKGFysngaassvstKHALI-MDEVDGMAGNEDRGGIQELIGLIKHTK 575
Cdd:PRK04195  62 DYGWEVIELNASDQRTADVIERVAGEAATSGSLFGA-----------RRKLIlLDEVDGIHGNEDRGGARAILELIKKAK 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418 576 IPIICMCNDRNHPKIRSLVHYCFDLRFQRPRVEQIKGAMMSIAFKEGLKIPPPAMNEIILGANQDIRQVLHNLSMWCARS 655
Cdd:PRK04195 131 QPIILTANDPYDPSLRELRNACLMIEFKRLSTRSIVPVLKRICRKEGIECDDEALKEIAERSGGDLRSAINDLQAIAEGY 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418 656 KALTYDQAKAdshRAKKDIKMGPFDVARKVFA---AGEETAHMSLVDKS-DLFFHdysiaplFVQEN----YIHVKPVAA 727
Cdd:PRK04195 211 GKLTLEDVKT---LGRRDREESIFDALDAVFKarnADQALEASYDVDEDpDDLIE-------WIDENipkeYDDPEDIAR 280

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418 728 GGDMkkhlmlLSRAadsicdgDLVDSQIRSKQNWSLLPaqaiYASvlpgELM------------RGYmTQFpTFPSWLGK 795
Cdd:PRK04195 281 AYDA------LSRA-------DIFLGRVKRTQNYDLWR----YAS----DLMtagvalakekkkRGF-TRY-QPPSYWRL 337

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 767930418 796 HSSTGKHDRIVQDLALHMSLRTYSSKRTVNMDYLSLLR 833
Cdd:PRK04195 338 LSKTKEKRETRDSIAKKIAEKLHTSKRKVRREVLPFLS 375
Lig COG0272
NAD-dependent DNA ligase [Replication, recombination and repair];
398-479 8.48e-28

NAD-dependent DNA ligase [Replication, recombination and repair];


Pssm-ID: 440042 [Multi-domain]  Cd Length: 668  Bit Score: 120.13  E-value: 8.48e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418 398 EIPKGAENCLEGLIFVITGVLESIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGqSKSDKAAALGTKIIDEDGLLN 477
Cdd:COG0272  587 EAEAAADSPLAGKTFVLTGTLETMTRDEAKELIEALGGKVSGSVSKKTDYVVAGENAG-SKLDKAEELGVPILDEAEFLE 665


                 ..
gi 767930418 478 LI 479
Cdd:COG0272  666 LL 667
ligA PRK07956
NAD-dependent DNA ligase LigA; Validated
 392-479 1.71e-25

NAD-dependent DNA ligase LigA; Validated


Pssm-ID: 236137 [Multi-domain]  Cd Length: 665  Bit Score: 112.91  E-value: 1.71e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418 392 KALGSKEIPKGAENCLEGLIFVITGVLESIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGqSKSDKAAALGTKIID 471
Cdd:PRK07956 576 LEAGVNMEYKGEEVDLAGKTVVLTGTLEQLSRDEAKEKLEALGAKVSGSVSKKTDLVVAGEAAG-SKLAKAQELGIEVLD 654


                 ....*...
gi 767930418 472 EDGLLNLI 479
Cdd:PRK07956 655 EEEFLRLL 662
BRCT_DNA_ligase_like cd17748
BRCT domain of bacterial NAD-dependent DNA ligase (LigA) and similar proteins; LigA, also ...
 407-478 3.73e-24

BRCT domain of bacterial NAD-dependent DNA ligase (LigA) and similar proteins; LigA, also called NAD(+)-dependent polydeoxyribonucleotide synthase, catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this family.


Pssm-ID: 349379 [Multi-domain]  Cd Length: 76  Bit Score: 96.78  E-value: 3.73e-24
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767930418 407 LEGLIFVITGVLESIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSD----KAAALGTKIIDEDGLLNL 478
Cdd:cd17748    1 LAGKTFVFTGTLSSMSRDEAEELIEALGGKVQSSVSKKTDYLVVGDNAGSKLKKgeelKAKGLGIKIISEEEFLDL 76
BRCT pfam00533
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ...
 404-479 3.84e-15

BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.


Pssm-ID: 425736 [Multi-domain]  Cd Length: 75  Bit Score: 71.17  E-value: 3.84e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767930418  404 ENCLEGLIFVITGvLESIERDEAKSLIERYGGKVTGNVSKKTNYLVMgrDSGQSKSDKAAALGTKIIDEDGLLNLI 479
Cdd:pfam00533   3 EKLFSGKTFVITG-LDGLERDELKELIEKLGGKVTDSLSKKTTHVIV--EARTKKYLKAKELGIPIVTEEWLLDCI 75
BRCT smart00292
breast cancer carboxy-terminal domain;
404-479 1.95e-13

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 66.24  E-value: 1.95e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767930418   404 ENCLEGLIFVITGVLESIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAAA--LGTKIIDEDGLLNLI 479
Cdd:smart00292   1 PKLFKGKTFYITGSFDKEERDELKELIEALGGKVTSSLSSKTTTHVIVGSPEGGKLELLKAiaLGIPIVKEEWLLDCL 78
HLD_clamp_RFC cd18140
helical lid domain of replication factor C subunit; Replication factor C (RFC) is five-protein ...
 605-661 2.60e-10

helical lid domain of replication factor C subunit; Replication factor C (RFC) is five-protein clamp loader complex that forms a stable ATP-dependent complex with the sliding clamp, PCNA, which binds specifically to primed DNA. RFC subunits belong to the clamp loader clade of the AAA+ superfamily.


Pssm-ID: 350842 [Multi-domain]  Cd Length: 63  Bit Score: 56.77  E-value: 2.60e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767930418 605 PRVEQIKGAMMSIAFKEGLKIPPPAMNEIILGANQDIRQVLHNLSMWCARSKALTYD 661
Cdd:cd18140    1 LSKEQIVKRLREICKKEGVKIDEEALEAIAEKSEGDMRKAINDLQAAAAGGGVITEE 57
BRCT cd00027
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ...
 410-473 6.76e-09

C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.


Pssm-ID: 349339 [Multi-domain]  Cd Length: 68  Bit Score: 53.13  E-value: 6.76e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767930418 410 LIFVITGvLESIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAAALGTKIIDED 473
Cdd:cd00027    1 LVICFSG-LDDEEREELKKLIEALGGKVSESLSSKVTHLIAKSPSGEKYYLAALAWGIPIVSPE 63
PTZ00121 PTZ00121
MAEBL; Provisional
 14-404 1.02e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 59.77  E-value: 1.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418   14 KKLVSETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDSESEETLQVKNAKKPPEKLP--- 90
Cdd:PTZ00121 1328 KKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKkka 1407

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418   91 --VSSKPGKISRQDPVTYISETDEEDDFMCKKA--ASKSKENGRSTNSHLGTSNMKKNEENTKTKNKplSPIKLTPTSVL 166
Cdd:PTZ00121 1408 deLKKAAAAKKKADEAKKKAEEKKKADEAKKKAeeAKKADEAKKKAEEAKKAEEAKKKAEEAKKADE--AKKKAEEAKKA 1485

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418  167 DYFGTGSVQRSNKKMVASKRKELSQNTDESGLNDEA-IAKQLQLDEDAELERQLHEDEEF--ARTLAMLDEEPKTKKARK 243
Cdd:PTZ00121 1486 DEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAkKADEAKKAEEAKKADEAKKAEEKkkADELKKAEELKKAEEKKK 1565

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418  244 DTEAGETFSSVQANLSKAEKHKyphKVKTAQVSDERKSYSPRKQSKYESSKESQQhSKSSADKIGEVSSPKasSKLAIMK 323
Cdd:PTZ00121 1566 AEEAKKAEEDKNMALRKAEEAK---KAEEARIEEVMKLYEEEKKMKAEEAKKAEE-AKIKAEELKKAEEEK--KKVEQLK 1639

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418  324 RKEESSYKEIEPVASKRKENAIKLKGETKTPKKTKSspaKKESVSPEDSEKKRTNYQayrsyLNREGPKALGSKEIPKGA 403
Cdd:PTZ00121 1640 KKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKK---KAEEAKKAEEDEKKAAEA-----LKKEAEEAKKAEELKKKE 1711


                  .
gi 767930418  404 E 404
Cdd:PTZ00121 1712 A 1712
PRK06195 PRK06195
DNA polymerase III subunit epsilon; Validated
 326-480 2.25e-08

DNA polymerase III subunit epsilon; Validated


Pssm-ID: 235735 [Multi-domain]  Cd Length: 309  Bit Score: 56.71  E-value: 2.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418 326 EESSYKEIEPVASKRKENAIKLKGETKTPKKTKSSPAKKESvsPEDSEKKRtnyqayrsylnregpkalgsKEIPKGAEN 405
Cdd:PRK06195 162 KELNSKDINEISKLLGVTLGYVNENGYKPSSRKGRILKRSN--RQAPRKKK--------------------KIIESFGFT 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418 406 CLEGLIFVITGVLESIERDEAKSLIERYGGKVTGNVSKKTNYLVMG--------RDSGQSKSDKAAAL-----GTKIIDE 472
Cdd:PRK06195 220 AFKEEVVVFTGGLASMTRDEAMILVRRLGGTVGSSVTKKTTYLVTNtkdiedlnREEMSNKLKKAIDLkkkgqNIKFLNE 299


                 ....*...
gi 767930418 473 DGLLNLIR 480
Cdd:PRK06195 300 EEFLQKCK 307
PTZ00121 PTZ00121
MAEBL; Provisional
 14-405 1.16e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 52.84  E-value: 1.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418   14 KKLVSETVKKNEKTKSDEETLKA---KKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDS--ESEETLQVKNAKKPPEK 88
Cdd:PTZ00121 1496 KKKADEAKKAAEAKKKADEAKKAeeaKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEElkKAEEKKKAEEAKKAEED 1575

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418   89 LPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKengRSTNSHLGTSNMKKNEENTKtknkplspikltptsvldy 168
Cdd:PTZ00121 1576 KNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAK---KAEEAKIKAEELKKAEEEKK------------------- 1633

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418  169 fgtgSVQRSNKKMVASKRK--ELSQNTDESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKKAR--KD 244
Cdd:PTZ00121 1634 ----KVEQLKKKEAEEKKKaeELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEelKK 1709

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418  245 TEAGETFSSVQANLSKAEKHKYPHKVKTAQVSDERKSYSPRKQSkyESSKESQQHSKSSADKIGEVSSPKASSKLAIMKR 324
Cdd:PTZ00121 1710 KEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDE--EEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDE 1787

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418  325 KEESSYKEIEpvaskRKENAIKLKGETKTPKKTKSSPAKKESVSPEDSEKKRTnyqAYRSYLNREGPKALGSKEIPKGAE 404
Cdd:PTZ00121 1788 EDEKRRMEVD-----KKIKDIFDNFANIIEGGKEGNLVINDSKEMEDSAIKEV---ADSKNMQLEEADAFEKHKFNKNNE 1859


                  .
gi 767930418  405 N 405
Cdd:PTZ00121 1860 N 1860
PTZ00121 PTZ00121
MAEBL; Provisional
 14-375 1.70e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 52.45  E-value: 1.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418   14 KKLVSETVKKNEKTKSDEETLK----AKKGIKEI--KVNSSRKEDDFKQKQPSKKKRIIYDSDSESE-ETLQVKNAKKPP 86
Cdd:PTZ00121 1301 KKKADEAKKKAEEAKKADEAKKkaeeAKKKADAAkkKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEaAEKKKEEAKKKA 1380

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418   87 EKLpvSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRSTnshlgtsnmKKNEENTKT---KNKPLSPIKLTPT 163
Cdd:PTZ00121 1381 DAA--KKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAK---------KKAEEKKKAdeaKKKAEEAKKADEA 1449

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418  164 SVLDYFGTGSVQRSNKKMVASKRKELSQNTDESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKKARK 243
Cdd:PTZ00121 1450 KKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKK 1529

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418  244 DTEAGETFSSVQA-NLSKAEKHKYPHKVKTAQ---VSDERKSYSPRKQSKYESSKESQQHSKSSADKIGEVSSPKASSKL 319
Cdd:PTZ00121 1530 AEEAKKADEAKKAeEKKKADELKKAEELKKAEekkKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKA 1609

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767930418  320 AIMKRKEESSYKEIEpvasKRKENAIKLKGEtKTPKKTKSSPAKKESVSPEDSEKK 375
Cdd:PTZ00121 1610 EEAKKAEEAKIKAEE----LKKAEEEKKKVE-QLKKKEAEEKKKAEELKKAEEENK 1660
BRCT_PARP1 cd17747
BRCT domain of poly [ADP-ribose] polymerase 1 (PARP-1) and similar proteins; PARP-1 (EC 2.4.2. ...
 407-473 5.58e-06

BRCT domain of poly [ADP-ribose] polymerase 1 (PARP-1) and similar proteins; PARP-1 (EC 2.4.2.30), also termed ADP-ribosyltransferase diphtheria toxin-like 1 (ARTD1), or NAD(+) ADP-ribosyltransferase 1 (ADPRT 1), or poly[ADP-ribose] synthase 1, is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism.


Pssm-ID: 349378 [Multi-domain]  Cd Length: 76  Bit Score: 45.21  E-value: 5.58e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418 407 LEGLIFVITGVLeSIERDEAKSLIERYGGKVTGNVSKKTNYLV---MGRDSGQSKSDKAAALGTKIIDED 473
Cdd:cd17747    1 LTGMKFALIGKL-SKSKDELKKLIEKLGGKVASKVTKKVTLCIstkAEVEKMSKKMKEAKEAGVPVVSED 69
BRCT_TopBP1_rpt2_like cd17731
second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 407-456 1.29e-05

second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the second BRCT domain.


Pssm-ID: 349363 [Multi-domain]  Cd Length: 77  Bit Score: 44.07  E-value: 1.29e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 767930418 407 LEGLIFVITGvLESIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQ 456
Cdd:cd17731    3 FKGLVICVTG-FDSEERKEIQQLVEQNGGSYSPDLSKNCTHLIAGSPSGQ 51
PTZ00121 PTZ00121
MAEBL; Provisional
 18-404 2.29e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 48.60  E-value: 2.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418   18 SETVKKNEKTKSDEETLKA---KKGIKEIKVNSSRKEDDFKQKQPSKKkriiYDSDSESEETLQVKNAKKPPEKlpvsSK 94
Cdd:PTZ00121 1172 AEDAKKAEAARKAEEVRKAeelRKAEDARKAEAARKAEEERKAEEARK----AEDAKKAEAVKKAEEAKKDAEE----AK 1243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418   95 PGKISRQDPVTYISETDEEDDFMCKKAASKSKEnGRSTNSHLGTSNMKKNEENTKTKNKPLS---PIKLTPTSVLDYFGT 171
Cdd:PTZ00121 1244 KAEEERNNEEIRKFEEARMAHFARRQAAIKAEE-ARKADELKKAEEKKKADEAKKAEEKKKAdeaKKKAEEAKKADEAKK 1322

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418  172 GSVQRSNKKMVASKRKELSQNTDESG-LNDEAIAKQLQLDEDAELERQLHEDEEF--ARTLAMLDEEPKT-----KKARK 243
Cdd:PTZ00121 1323 KAEEAKKKADAAKKKAEEAKKAAEAAkAEAEAAADEAEAAEEKAEAAEKKKEEAKkkADAAKKKAEEKKKadeakKKAEE 1402

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418  244 DTEAGETFSSVQANLSKAEKHKYPHKVKTAQVSDERKSYSPRKQSKYESSKESQQHSKSSADKIGEVSSPKASSKLAIMK 323
Cdd:PTZ00121 1403 DKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEA 1482

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418  324 RKEESSYKEIEPvASKRKENAIKLKGETKTPKKTKSSPAKKESVSPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGA 403
Cdd:PTZ00121 1483 KKADEAKKKAEE-AKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAE 1561


                  .
gi 767930418  404 E 404
Cdd:PTZ00121 1562 E 1562
PTZ00121 PTZ00121
MAEBL; Provisional
 25-404 3.00e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 48.21  E-value: 3.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418   25 EKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRiiyDSDSESEETLQVKNAKKPPE-KLPVSSKPGKISRQDP 103
Cdd:PTZ00121 1085 EDNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKA---EDARKAEEARKAEDARKAEEaRKAEDAKRVEIARKAE 1161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418  104 VTYISETDEEDDFMCKKAASKSKENGRSTNSHLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKKMVA 183
Cdd:PTZ00121 1162 DARKAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEE 1241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418  184 SKRKELSQNTDESGLNDEAIAKQL---QLDEDAELERQLHE---------DEEFARTLAMLDEEPKTKKARKDTEAGETF 251
Cdd:PTZ00121 1242 AKKAEEERNNEEIRKFEEARMAHFarrQAAIKAEEARKADElkkaeekkkADEAKKAEEKKKADEAKKKAEEAKKADEAK 1321

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418  252 SSVQANLSKAE--KHKYPHKVKTAQVSDERKSYSPRKQSKYESSKESQQHSKSSADKIGEVSSPKASS--KLAIMKRKEE 327
Cdd:PTZ00121 1322 KKAEEAKKKADaaKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEkkKADEAKKKAE 1401

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418  328 SSYKEIEPV----ASKRKENAIKLKGETKtpKKTKSSPAKKESVSPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGA 403
Cdd:PTZ00121 1402 EDKKKADELkkaaAAKKKADEAKKKAEEK--KKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKA 1479


                  .
gi 767930418  404 E 404
Cdd:PTZ00121 1480 E 1480
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 174-398 9.90e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 46.22  E-value: 9.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418 174 VQRSNKKMvASKRKELSQNTDESGLNDEAIAKQLQLDEDAELERQLHEDEEFArtlamldEEPKTKKARKDTEAGEtfss 253
Cdd:PTZ00449 489 IKKSKKKL-APIEEEDSDKHDEPPEGPEASGLPPKAPGDKEGEEGEHEDSKES-------DEPKEGGKPGETKEGE---- 556

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418 254 VQANLSKAEKHKyPHKVK--TAQVSDERKSYSPRKQSKYESSKESQQHSKSSADKigevsSPK--ASSKLAIMKRKEESS 329
Cdd:PTZ00449 557 VGKKPGPAKEHK-PSKIPtlSKKPEFPKDPKHPKDPEEPKKPKRPRSAQRPTRPK-----SPKlpELLDIPKSPKRPESP 630

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767930418 330 YKEIEPVASKRKENAIKLKGeTKTPKKTKSSPAKKESVSPEDSEKkrtnyqAYRSYLNregpKALGSKE 398
Cdd:PTZ00449 631 KSPKRPPPPQRPSSPERPEG-PKIIKSPKPPKSPKPPFDPKFKEK------FYDDYLD----AAAKSKE 688
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 497-606 3.13e-04

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 41.81  E-value: 3.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418  497 ELGYSYVELNASDTRSKsslkaIVAESLNNtsIKGFYSNgaASSVStKHALIMDEVDGMAGNEDRGGIQELIGLI----- 571
Cdd:pfam00004  21 ELGAPFIEISGSELVSK-----YVGESEKR--LRELFEA--AKKLA-PCVIFIDEIDALAGSRGSGGDSESRRVVnqllt 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 767930418  572 -------KHTKIPIICMCNdrNHPKIRSLVHYCFDLRFQRPR 606
Cdd:pfam00004  91 eldgftsSNSKVIVIAATN--RPDKLDPALLGRFDRIIEFPL 130
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 491-602 3.69e-04

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 41.75  E-value: 3.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418 491 IAVETEELGYSYVELNASDTRSKsslkAIVAESLNNTSIKGFYSNGAASSVSTkhaLIMDEVDGMAGNEDRGGIQEL--- 567
Cdd:cd00009   39 IANELFRPGAPFLYLNASDLLEG----LVVAELFGHFLVRLLFELAEKAKPGV---LFIDEIDSLSRGAQNALLRVLetl 111

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 767930418 568 -IGLIKHTKIPIICMCNDRNHPKIRSLVHYCFDLRF 602
Cdd:cd00009  112 nDLRIDRENVRVIGATNRPLLGDLDRALYDRLDIRI 147
PTZ00121 PTZ00121
MAEBL; Provisional
 18-317 3.34e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.67  E-value: 3.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418   18 SETVKKNEKtKSDEETLKAKKGIKEIKVNSSRKEDDFK------QKQPSKKKRIIYDSDSESEETLQVKNAKKPPEKLPV 91
Cdd:PTZ00121 1583 AEEAKKAEE-ARIEEVMKLYEEEKKMKAEEAKKAEEAKikaeelKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKI 1661

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418   92 SSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRSTNSHlgtsNMKKNEENTKTKNKPLSPIKltptsvldyfgt 171
Cdd:PTZ00121 1662 KAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAE----ELKKKEAEEKKKAEELKKAE------------ 1725

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930418  172 gSVQRSNKKMVASKRKELSQNTDESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKKARKDTEAGETF 251
Cdd:PTZ00121 1726 -EENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIF 1804

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767930418  252 SSVqANLSKAEKHKYPHKVKTAQVSD-ERKSYSPRKQSKYESSKESQQHSKSSADKIGEVSSPKASS 317
Cdd:PTZ00121 1805 DNF-ANIIEGGKEGNLVINDSKEMEDsAIKEVADSKNMQLEEADAFEKHKFNKNNENGEDGNKEADF 1870
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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