NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767929927|ref|XP_011512204|]
View 

prominin-1 isoform X5 [Homo sapiens]

Protein Classification

prominin family protein( domain architecture ID 12063338)

prominin family protein is a pentaspan membrane glycoprotein similar to human prominin-1 that binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in cell differentiation, proliferation, and apoptosis

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Prominin pfam05478
Prominin; The prominins are an emerging family of proteins that among the multispan membrane ...
18-820 0e+00

Prominin; The prominins are an emerging family of proteins that among the multispan membrane proteins display a novel topology. Mouse prominin and human prominin (mouse)-like 1 (PROML1) are predicted to contain five membrane spanning domains, with an N-terminal domain exposed to the extracellular space followed by four, alternating small cytoplasmic and large extracellular, loops and a cytoplasmic C-terminal domain. The exact function of prominin is unknown although in humans defects in PROM1, the gene coding for prominin, cause retinal degeneration.


:

Pssm-ID: 461660 [Multi-domain]  Cd Length: 799  Bit Score: 1072.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929927   18 FSGGQPSSTDAPKAWNYELPATNYETQD-SHKAGPIGILFELVHIFLYVVQPRDFPEDTLRKFLQKAYESKIDYDKPETV 96
Cdd:pfam05478   1 TTHEQLGQTHPPSVLYTEYPPPTYYTADlTYPAGALGPLYNFVHSFLDVVQPNPFPPGYIRKLINKKLALGPKVEKNDWS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929927   97 ILGLKIVYYEAGIILCCVLGLLFIILMPLVGYFFCMCRCCNKCGGEMHQRQKENGPFLRKCFAISLLVICIIISIGIFYG 176
Cdd:pfam05478  81 VLLAEVVRYEAGILVCAVIGLLYIILMPFIGLCFCCCRCCRRCGGEMHQCQKKNDACRRKTLGVSLLLLTLLLLIGIIIA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929927  177 FVANHQVRTRIKRSRKLADSNFKDLRTLLNETPEQIKYILAQ-YNTTKDKAFTDLNSINSVLGGGILDRLRPNIIPVLDE 255
Cdd:pfam05478 161 FVTNQYLDRGIGESTETMRRGLRDLRTFLSDVPQHIDHVLVQnYSELQDHVSDDLDDAGKHIGLDIHDTLESNVYPALAE 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929927  256 IKSMATAIKETKEALENMNSTLKSLHQQSTQLSSSLTSVKTSLRSSLNDPLClvhpSSETCNSIRLSLSQ--LNSNPELR 333
Cdd:pfam05478 241 LERILQNMPEAKDLLEQVNALLKDLRFYGTQLRDGLRGVKRDLNYALSNPLC----TTQECDKFLSSLSIefLDTSACLD 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929927  334 QLPPVDAELDNVNNVLRTDLDGLVQQGYQSLNDIPDRVQRQTTTVVAGIKRVLNSIGSDIDNVTQRLPiQDILSAFSVYV 413
Cdd:pfam05478 317 QLPNVDEFLENVKGVIETNLSSIVQEGLDRFNNIPEKVKNQTAGVVPPLKRALAQIREQIRTLATDIP-RDALSAVSSDI 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929927  414 NNTESYIHRNLPTLEEYDSYWWLGGLVICSLLTLIVIFYYLGLLCGVCGYDRHATPTTRGCVSNTGGVFLMVGVGLSFLF 493
Cdd:pfam05478 396 HNTERSSRTFLDVVEKYGSYRWLIGLILCSLILLIVVCLLLGLLCGICGLRRTATPTDRGCSKNTGARFLMVGVGLSFLF 475
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929927  494 CWILMIIVVLTFVFGANVEKLICEPYTSKELFRVLDTPYLLnedWEYYLSGKLFNKSKMKLTFEQVYSDCKKNRGTYGTL 573
Cdd:pfam05478 476 FWFLMLVVLLYFLVGGNTYTLVCAPWENNELFRFLDTPGLL---PEIDLSRYLPGGLKPNLTISQAYSACKANQSIFTVL 552
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929927  574 HLQNSFNISEHLNINEHTGSISSELESLKVNL-NIFLLGAAGRKNLQDFAACGIDRMNYDSYLAQTGKSPAGVNLLSFAY 652
Cdd:pfam05478 553 RLNNIYDISKLLNISVYTEEIQQELENLKVDLsNIDLLTPEERRDLEALRESGLSTIHYSLYLQQLCKPFTKVNLLTLAD 632
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929927  653 DLEAKANSLPPGNLRNSLKRDAQTIKTIHQQRVLPIEQSLSTLYQSVKILQRTGNGLLERVTRILASLDFAQNFITNNTS 732
Cdd:pfam05478 633 KLEGLANSLPNGNLKVSLQNEAQDLRAIHQEFVLPLQSLVAKLNQSVKELDSSNNDLNNSITNLLDAVERAENFLPNNGS 712
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929927  733 SVIIEETKKYGRTIIGYFEHYLQWIEFSISEKVASCKPVATALDTAVdVFLCSYIIDPLNLFWFGIGKATVFLLPALIFA 812
Cdd:pfam05478 713 SIINNESENLLDRIMGYFEQYIDWVIEEVTENVGHCKPLAYAYDSGV-VLLCDRLVDPINAFWFGLGWCTLLLLPSIIFA 791

                  ....*...
gi 767929927  813 VKLAKYYR 820
Cdd:pfam05478 792 VKLAKYYR 799
 
Name Accession Description Interval E-value
Prominin pfam05478
Prominin; The prominins are an emerging family of proteins that among the multispan membrane ...
18-820 0e+00

Prominin; The prominins are an emerging family of proteins that among the multispan membrane proteins display a novel topology. Mouse prominin and human prominin (mouse)-like 1 (PROML1) are predicted to contain five membrane spanning domains, with an N-terminal domain exposed to the extracellular space followed by four, alternating small cytoplasmic and large extracellular, loops and a cytoplasmic C-terminal domain. The exact function of prominin is unknown although in humans defects in PROM1, the gene coding for prominin, cause retinal degeneration.


Pssm-ID: 461660 [Multi-domain]  Cd Length: 799  Bit Score: 1072.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929927   18 FSGGQPSSTDAPKAWNYELPATNYETQD-SHKAGPIGILFELVHIFLYVVQPRDFPEDTLRKFLQKAYESKIDYDKPETV 96
Cdd:pfam05478   1 TTHEQLGQTHPPSVLYTEYPPPTYYTADlTYPAGALGPLYNFVHSFLDVVQPNPFPPGYIRKLINKKLALGPKVEKNDWS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929927   97 ILGLKIVYYEAGIILCCVLGLLFIILMPLVGYFFCMCRCCNKCGGEMHQRQKENGPFLRKCFAISLLVICIIISIGIFYG 176
Cdd:pfam05478  81 VLLAEVVRYEAGILVCAVIGLLYIILMPFIGLCFCCCRCCRRCGGEMHQCQKKNDACRRKTLGVSLLLLTLLLLIGIIIA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929927  177 FVANHQVRTRIKRSRKLADSNFKDLRTLLNETPEQIKYILAQ-YNTTKDKAFTDLNSINSVLGGGILDRLRPNIIPVLDE 255
Cdd:pfam05478 161 FVTNQYLDRGIGESTETMRRGLRDLRTFLSDVPQHIDHVLVQnYSELQDHVSDDLDDAGKHIGLDIHDTLESNVYPALAE 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929927  256 IKSMATAIKETKEALENMNSTLKSLHQQSTQLSSSLTSVKTSLRSSLNDPLClvhpSSETCNSIRLSLSQ--LNSNPELR 333
Cdd:pfam05478 241 LERILQNMPEAKDLLEQVNALLKDLRFYGTQLRDGLRGVKRDLNYALSNPLC----TTQECDKFLSSLSIefLDTSACLD 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929927  334 QLPPVDAELDNVNNVLRTDLDGLVQQGYQSLNDIPDRVQRQTTTVVAGIKRVLNSIGSDIDNVTQRLPiQDILSAFSVYV 413
Cdd:pfam05478 317 QLPNVDEFLENVKGVIETNLSSIVQEGLDRFNNIPEKVKNQTAGVVPPLKRALAQIREQIRTLATDIP-RDALSAVSSDI 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929927  414 NNTESYIHRNLPTLEEYDSYWWLGGLVICSLLTLIVIFYYLGLLCGVCGYDRHATPTTRGCVSNTGGVFLMVGVGLSFLF 493
Cdd:pfam05478 396 HNTERSSRTFLDVVEKYGSYRWLIGLILCSLILLIVVCLLLGLLCGICGLRRTATPTDRGCSKNTGARFLMVGVGLSFLF 475
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929927  494 CWILMIIVVLTFVFGANVEKLICEPYTSKELFRVLDTPYLLnedWEYYLSGKLFNKSKMKLTFEQVYSDCKKNRGTYGTL 573
Cdd:pfam05478 476 FWFLMLVVLLYFLVGGNTYTLVCAPWENNELFRFLDTPGLL---PEIDLSRYLPGGLKPNLTISQAYSACKANQSIFTVL 552
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929927  574 HLQNSFNISEHLNINEHTGSISSELESLKVNL-NIFLLGAAGRKNLQDFAACGIDRMNYDSYLAQTGKSPAGVNLLSFAY 652
Cdd:pfam05478 553 RLNNIYDISKLLNISVYTEEIQQELENLKVDLsNIDLLTPEERRDLEALRESGLSTIHYSLYLQQLCKPFTKVNLLTLAD 632
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929927  653 DLEAKANSLPPGNLRNSLKRDAQTIKTIHQQRVLPIEQSLSTLYQSVKILQRTGNGLLERVTRILASLDFAQNFITNNTS 732
Cdd:pfam05478 633 KLEGLANSLPNGNLKVSLQNEAQDLRAIHQEFVLPLQSLVAKLNQSVKELDSSNNDLNNSITNLLDAVERAENFLPNNGS 712
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929927  733 SVIIEETKKYGRTIIGYFEHYLQWIEFSISEKVASCKPVATALDTAVdVFLCSYIIDPLNLFWFGIGKATVFLLPALIFA 812
Cdd:pfam05478 713 SIINNESENLLDRIMGYFEQYIDWVIEEVTENVGHCKPLAYAYDSGV-VLLCDRLVDPINAFWFGLGWCTLLLLPSIIFA 791

                  ....*...
gi 767929927  813 VKLAKYYR 820
Cdd:pfam05478 792 VKLAKYYR 799
 
Name Accession Description Interval E-value
Prominin pfam05478
Prominin; The prominins are an emerging family of proteins that among the multispan membrane ...
18-820 0e+00

Prominin; The prominins are an emerging family of proteins that among the multispan membrane proteins display a novel topology. Mouse prominin and human prominin (mouse)-like 1 (PROML1) are predicted to contain five membrane spanning domains, with an N-terminal domain exposed to the extracellular space followed by four, alternating small cytoplasmic and large extracellular, loops and a cytoplasmic C-terminal domain. The exact function of prominin is unknown although in humans defects in PROM1, the gene coding for prominin, cause retinal degeneration.


Pssm-ID: 461660 [Multi-domain]  Cd Length: 799  Bit Score: 1072.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929927   18 FSGGQPSSTDAPKAWNYELPATNYETQD-SHKAGPIGILFELVHIFLYVVQPRDFPEDTLRKFLQKAYESKIDYDKPETV 96
Cdd:pfam05478   1 TTHEQLGQTHPPSVLYTEYPPPTYYTADlTYPAGALGPLYNFVHSFLDVVQPNPFPPGYIRKLINKKLALGPKVEKNDWS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929927   97 ILGLKIVYYEAGIILCCVLGLLFIILMPLVGYFFCMCRCCNKCGGEMHQRQKENGPFLRKCFAISLLVICIIISIGIFYG 176
Cdd:pfam05478  81 VLLAEVVRYEAGILVCAVIGLLYIILMPFIGLCFCCCRCCRRCGGEMHQCQKKNDACRRKTLGVSLLLLTLLLLIGIIIA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929927  177 FVANHQVRTRIKRSRKLADSNFKDLRTLLNETPEQIKYILAQ-YNTTKDKAFTDLNSINSVLGGGILDRLRPNIIPVLDE 255
Cdd:pfam05478 161 FVTNQYLDRGIGESTETMRRGLRDLRTFLSDVPQHIDHVLVQnYSELQDHVSDDLDDAGKHIGLDIHDTLESNVYPALAE 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929927  256 IKSMATAIKETKEALENMNSTLKSLHQQSTQLSSSLTSVKTSLRSSLNDPLClvhpSSETCNSIRLSLSQ--LNSNPELR 333
Cdd:pfam05478 241 LERILQNMPEAKDLLEQVNALLKDLRFYGTQLRDGLRGVKRDLNYALSNPLC----TTQECDKFLSSLSIefLDTSACLD 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929927  334 QLPPVDAELDNVNNVLRTDLDGLVQQGYQSLNDIPDRVQRQTTTVVAGIKRVLNSIGSDIDNVTQRLPiQDILSAFSVYV 413
Cdd:pfam05478 317 QLPNVDEFLENVKGVIETNLSSIVQEGLDRFNNIPEKVKNQTAGVVPPLKRALAQIREQIRTLATDIP-RDALSAVSSDI 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929927  414 NNTESYIHRNLPTLEEYDSYWWLGGLVICSLLTLIVIFYYLGLLCGVCGYDRHATPTTRGCVSNTGGVFLMVGVGLSFLF 493
Cdd:pfam05478 396 HNTERSSRTFLDVVEKYGSYRWLIGLILCSLILLIVVCLLLGLLCGICGLRRTATPTDRGCSKNTGARFLMVGVGLSFLF 475
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929927  494 CWILMIIVVLTFVFGANVEKLICEPYTSKELFRVLDTPYLLnedWEYYLSGKLFNKSKMKLTFEQVYSDCKKNRGTYGTL 573
Cdd:pfam05478 476 FWFLMLVVLLYFLVGGNTYTLVCAPWENNELFRFLDTPGLL---PEIDLSRYLPGGLKPNLTISQAYSACKANQSIFTVL 552
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929927  574 HLQNSFNISEHLNINEHTGSISSELESLKVNL-NIFLLGAAGRKNLQDFAACGIDRMNYDSYLAQTGKSPAGVNLLSFAY 652
Cdd:pfam05478 553 RLNNIYDISKLLNISVYTEEIQQELENLKVDLsNIDLLTPEERRDLEALRESGLSTIHYSLYLQQLCKPFTKVNLLTLAD 632
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929927  653 DLEAKANSLPPGNLRNSLKRDAQTIKTIHQQRVLPIEQSLSTLYQSVKILQRTGNGLLERVTRILASLDFAQNFITNNTS 732
Cdd:pfam05478 633 KLEGLANSLPNGNLKVSLQNEAQDLRAIHQEFVLPLQSLVAKLNQSVKELDSSNNDLNNSITNLLDAVERAENFLPNNGS 712
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929927  733 SVIIEETKKYGRTIIGYFEHYLQWIEFSISEKVASCKPVATALDTAVdVFLCSYIIDPLNLFWFGIGKATVFLLPALIFA 812
Cdd:pfam05478 713 SIINNESENLLDRIMGYFEQYIDWVIEEVTENVGHCKPLAYAYDSGV-VLLCDRLVDPINAFWFGLGWCTLLLLPSIIFA 791

                  ....*...
gi 767929927  813 VKLAKYYR 820
Cdd:pfam05478 792 VKLAKYYR 799
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH