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Conserved domains on  [gi|767939288|ref|XP_011512615|]
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lysophospholipid acyltransferase 1 isoform X3 [Homo sapiens]

Protein Classification

membrane-bound O-acyltransferase family protein( domain architecture ID 326)

membrane-bound O-acyltransferase (MBOAT) family protein may be an integral transmembrane enzyme that modifies protective cell-surface polymers, catalyzing the transfer of an acetyl group from acetyl-CoA to its target substrates

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MBOAT super family cl00738
MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) ...
 22-240 2.29e-26

MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) family of membrane proteins contains a variety of acyltransferase enzymes. A conserved histidine has been suggested to be the active site residue.


The actual alignment was detected with superfamily member PLN02332:

Pssm-ID: 445070  Cd Length: 465  Bit Score: 105.91  E-value: 2.29e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939288  22 PLSELLGIPLDQVNFVVCQLVALFAAFWFRIYlrPGTTssdVRHAVATIFGIYFVIFCFGwYSVHLFVLVLMC--YAIMV 99
Cdd:PLN02332   7 SLASAIGVSVPVLRFLLCFVASIPLSALWRFI--PSGT---LRHLYAALSGAFLSYLSFG-FSSNLHFVVPMIagYLAMA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939288 100 tasvsnIHR-----YSFFVAMGYLTICHISRIYIFHYGILTTDFSGPLMIVTQKITTLAFQVHDGLgRRAEDLSAEQHRL 174
Cdd:PLN02332  81 ------LARrrcgaITFLFAFAYLIYCHVFYMSGDAWKEGGIDFTGALMVLTLKVISCAMNYQDGL-LKEEGLREAQKKN 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767939288 175 AIKVKPSFLEYLSYLLNFMSVIAGPCNNFKDYIAFIEGKHIhmkllevnWKRKgfHSLPEPSPTGH 240
Cdd:PLN02332 154 RLIQLPSLIEYLGYCLCCGSHLAGPVFEFRDYLDWTEGKGL--------WDPN--AKGKCPSPYGA 209
 
Name Accession Description Interval E-value
PLN02332 PLN02332
membrane bound O-acyl transferase (MBOAT) family protein
 22-240 2.29e-26

membrane bound O-acyl transferase (MBOAT) family protein


Pssm-ID: 215190  Cd Length: 465  Bit Score: 105.91  E-value: 2.29e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939288  22 PLSELLGIPLDQVNFVVCQLVALFAAFWFRIYlrPGTTssdVRHAVATIFGIYFVIFCFGwYSVHLFVLVLMC--YAIMV 99
Cdd:PLN02332   7 SLASAIGVSVPVLRFLLCFVASIPLSALWRFI--PSGT---LRHLYAALSGAFLSYLSFG-FSSNLHFVVPMIagYLAMA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939288 100 tasvsnIHR-----YSFFVAMGYLTICHISRIYIFHYGILTTDFSGPLMIVTQKITTLAFQVHDGLgRRAEDLSAEQHRL 174
Cdd:PLN02332  81 ------LARrrcgaITFLFAFAYLIYCHVFYMSGDAWKEGGIDFTGALMVLTLKVISCAMNYQDGL-LKEEGLREAQKKN 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767939288 175 AIKVKPSFLEYLSYLLNFMSVIAGPCNNFKDYIAFIEGKHIhmkllevnWKRKgfHSLPEPSPTGH 240
Cdd:PLN02332 154 RLIQLPSLIEYLGYCLCCGSHLAGPVFEFRDYLDWTEGKGL--------WDPN--AKGKCPSPYGA 209
COG5202 COG5202
Predicted membrane protein [Function unknown];
23-210 1.01e-10

Predicted membrane protein [Function unknown];


Pssm-ID: 227529  Cd Length: 512  Bit Score: 61.14  E-value: 1.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939288  23 LSELLGIPLDQVNFVVCQLVAL-FAAFWFRIYLRPGTtssdvRHAVATIFGIYFVIFCFGWYSVH--LFVLVLMCYAIMV 99
Cdd:COG5202   12 IKKLSGVNYLELRFLACLLLTLpFVSILKRNPTRIRT-----HNLFSISLILFYLFGVRHLVSGAyiLASISLFTYLLRY 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939288 100 TASVSNIHRYSFFVAMGYLTICHISRiYIFHYGILTTDFSGPLMIVTQKITTLAFQVHDGlGRRAEDLSAEQHRLAIKVK 179
Cdd:COG5202   87 FYRSAYMPTVLFIVILGHYKIFHAAQ-LFEERISTSFDITGSQMVLTMKLTSFAWSYYDG-KEYSSDLTEHQKSRARRGT 164

                        170       180       190
                 ....*....|....*....|....*....|.
gi 767939288 180 PSFLEYLSYLLNFMSVIAGPCNNFKDYIAFI 210
Cdd:COG5202  165 PTVLDFLSYIFFIPGLLLGPAFDYADFDSWL 195
 
Name Accession Description Interval E-value
PLN02332 PLN02332
membrane bound O-acyl transferase (MBOAT) family protein
 22-240 2.29e-26

membrane bound O-acyl transferase (MBOAT) family protein


Pssm-ID: 215190  Cd Length: 465  Bit Score: 105.91  E-value: 2.29e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939288  22 PLSELLGIPLDQVNFVVCQLVALFAAFWFRIYlrPGTTssdVRHAVATIFGIYFVIFCFGwYSVHLFVLVLMC--YAIMV 99
Cdd:PLN02332   7 SLASAIGVSVPVLRFLLCFVASIPLSALWRFI--PSGT---LRHLYAALSGAFLSYLSFG-FSSNLHFVVPMIagYLAMA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939288 100 tasvsnIHR-----YSFFVAMGYLTICHISRIYIFHYGILTTDFSGPLMIVTQKITTLAFQVHDGLgRRAEDLSAEQHRL 174
Cdd:PLN02332  81 ------LARrrcgaITFLFAFAYLIYCHVFYMSGDAWKEGGIDFTGALMVLTLKVISCAMNYQDGL-LKEEGLREAQKKN 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767939288 175 AIKVKPSFLEYLSYLLNFMSVIAGPCNNFKDYIAFIEGKHIhmkllevnWKRKgfHSLPEPSPTGH 240
Cdd:PLN02332 154 RLIQLPSLIEYLGYCLCCGSHLAGPVFEFRDYLDWTEGKGL--------WDPN--AKGKCPSPYGA 209
COG5202 COG5202
Predicted membrane protein [Function unknown];
23-210 1.01e-10

Predicted membrane protein [Function unknown];


Pssm-ID: 227529  Cd Length: 512  Bit Score: 61.14  E-value: 1.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939288  23 LSELLGIPLDQVNFVVCQLVAL-FAAFWFRIYLRPGTtssdvRHAVATIFGIYFVIFCFGWYSVH--LFVLVLMCYAIMV 99
Cdd:COG5202   12 IKKLSGVNYLELRFLACLLLTLpFVSILKRNPTRIRT-----HNLFSISLILFYLFGVRHLVSGAyiLASISLFTYLLRY 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939288 100 TASVSNIHRYSFFVAMGYLTICHISRiYIFHYGILTTDFSGPLMIVTQKITTLAFQVHDGlGRRAEDLSAEQHRLAIKVK 179
Cdd:COG5202   87 FYRSAYMPTVLFIVILGHYKIFHAAQ-LFEERISTSFDITGSQMVLTMKLTSFAWSYYDG-KEYSSDLTEHQKSRARRGT 164

                        170       180       190
                 ....*....|....*....|....*....|.
gi 767939288 180 PSFLEYLSYLLNFMSVIAGPCNNFKDYIAFI 210
Cdd:COG5202  165 PTVLDFLSYIFFIPGLLLGPAFDYADFDSWL 195
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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