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Conserved domains on  [gi|767939881|ref|XP_011512850|]
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zinc finger protein 40 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
2111-2136 1.48e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.90  E-value: 1.48e-05
                           10        20
                   ....*....|....*....|....*.
gi 767939881  2111 MLKKHIRTHTDVRPYHCTYCNFSFKT 2136
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
430-454 1.43e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 1.43e-04
                           10        20
                   ....*....|....*....|....*
gi 767939881   430 LLKHIRSHTGERPYPCVTCGFSFKT 454
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 2097-2119 4.70e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.59  E-value: 4.70e-04
                           10        20
                   ....*....|....*....|...
gi 767939881  2097 YICEECGIRCKKPSMLKKHIRTH 2119
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 2272-2634 1.20e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 1.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939881 2272 AQSDYNRKTLSPGKARQRAARDENDTIP-SVDTSRSPCHQMSVDYPESEEILRSSMAGKAVAITQ----------SPSSV 2340
Cdd:PHA03247 2582 VTSRARRPDAPPQSARPRAPVDDRGDPRgPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVppperprddpAPGRV 2661

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939881 2341 RLP--------PAAAEHSPQ---------TAAGMPSVASPHPDPQEQkqqitlQPTPGLPSPHTHLFSHLPLHSQQQSRT 2403
Cdd:PHA03247 2662 SRPrrarrlgrAAQASSPPQrprrraarpTVGSLTSLADPPPPPPTP------EPAPHALVSATPLPPGPAAARQASPAL 2735

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939881 2404 PYNMVP--VGGIHVVPAGLTYSTFVPLQAGPVQLTIPAVSVVHRTLGTHRNTVTEVSGTTNPAGVAELSSVVPCIPIGqi 2481
Cdd:PHA03247 2736 PAAPAPpaVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLA-- 2813

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939881 2482 RVPGLQNLSTPGLQSLPSLSMETvnivglANTNMAPQVHPPGLALN---AVGLQVLTANPSSQSSPAPQA--HIPglqIL 2556
Cdd:PHA03247 2814 PAAALPPAASPAGPLPPPTSAQP------TAPPPPPGPPPPSLPLGgsvAPGGDVRRRPPSRSPAAKPAApaRPP---VR 2884

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939881 2557 NIALPTLIPSVSQVAV--DAQGAPEMPASQSKACETQPKQTSVASANQvsrtESPQGLPTvqrenakkvlNPPAPAGDHA 2634
Cdd:PHA03247 2885 RLARPAVSRSTESFALppDQPERPPQPQAPPPPQPQPQPPPPPQPQPP----PPPPPRPQ----------PPLAPTTDPA 2950
zf-C2H2_2 super family cl20464
C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger ...
 2125-2190 3.03e-03

C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger domain.


The actual alignment was detected with superfamily member pfam12756:

Pssm-ID: 463690  Cd Length: 98  Bit Score: 39.19  E-value: 3.03e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767939881  2125 YHCTYCNFSFKTKGNLTKHMKSKAHSKkcvdlgvsvglIDEQDTEESDEKQRFsyersgYDLEESD 2190
Cdd:pfam12756   50 NECLYCGKQFKSLEALRQHMRDKGHCK-----------IPYESEEEWLEIAEF------YDFSSSY 98
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
2111-2136 1.48e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.90  E-value: 1.48e-05
                           10        20
                   ....*....|....*....|....*.
gi 767939881  2111 MLKKHIRTHTDVRPYHCTYCNFSFKT 2136
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
430-454 1.43e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 1.43e-04
                           10        20
                   ....*....|....*....|....*
gi 767939881   430 LLKHIRSHTGERPYPCVTCGFSFKT 454
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 2097-2119 4.70e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.59  E-value: 4.70e-04
                           10        20
                   ....*....|....*....|...
gi 767939881  2097 YICEECGIRCKKPSMLKKHIRTH 2119
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2272-2634 1.20e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 1.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939881 2272 AQSDYNRKTLSPGKARQRAARDENDTIP-SVDTSRSPCHQMSVDYPESEEILRSSMAGKAVAITQ----------SPSSV 2340
Cdd:PHA03247 2582 VTSRARRPDAPPQSARPRAPVDDRGDPRgPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVppperprddpAPGRV 2661

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939881 2341 RLP--------PAAAEHSPQ---------TAAGMPSVASPHPDPQEQkqqitlQPTPGLPSPHTHLFSHLPLHSQQQSRT 2403
Cdd:PHA03247 2662 SRPrrarrlgrAAQASSPPQrprrraarpTVGSLTSLADPPPPPPTP------EPAPHALVSATPLPPGPAAARQASPAL 2735

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939881 2404 PYNMVP--VGGIHVVPAGLTYSTFVPLQAGPVQLTIPAVSVVHRTLGTHRNTVTEVSGTTNPAGVAELSSVVPCIPIGqi 2481
Cdd:PHA03247 2736 PAAPAPpaVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLA-- 2813

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939881 2482 RVPGLQNLSTPGLQSLPSLSMETvnivglANTNMAPQVHPPGLALN---AVGLQVLTANPSSQSSPAPQA--HIPglqIL 2556
Cdd:PHA03247 2814 PAAALPPAASPAGPLPPPTSAQP------TAPPPPPGPPPPSLPLGgsvAPGGDVRRRPPSRSPAAKPAApaRPP---VR 2884

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939881 2557 NIALPTLIPSVSQVAV--DAQGAPEMPASQSKACETQPKQTSVASANQvsrtESPQGLPTvqrenakkvlNPPAPAGDHA 2634
Cdd:PHA03247 2885 RLARPAVSRSTESFALppDQPERPPQPQAPPPPQPQPQPPPPPQPQPP----PPPPPRPQ----------PPLAPTTDPA 2950
zf-C2H2_2 pfam12756
C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger ...
 2125-2190 3.03e-03

C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger domain.


Pssm-ID: 463690  Cd Length: 98  Bit Score: 39.19  E-value: 3.03e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767939881  2125 YHCTYCNFSFKTKGNLTKHMKSKAHSKkcvdlgvsvglIDEQDTEESDEKQRFsyersgYDLEESD 2190
Cdd:pfam12756   50 NECLYCGKQFKSLEALRQHMRDKGHCK-----------IPYESEEEWLEIAEF------YDFSSSY 98
ZnF_C2H2 smart00355
zinc finger;
2125-2146 5.16e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 36.67  E-value: 5.16e-03
                            10        20
                    ....*....|....*....|..
gi 767939881   2125 YHCTYCNFSFKTKGNLTKHMKS 2146
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRT 22
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
2111-2136 1.48e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.90  E-value: 1.48e-05
                           10        20
                   ....*....|....*....|....*.
gi 767939881  2111 MLKKHIRTHTDVRPYHCTYCNFSFKT 2136
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
430-454 1.43e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 1.43e-04
                           10        20
                   ....*....|....*....|....*
gi 767939881   430 LLKHIRSHTGERPYPCVTCGFSFKT 454
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 2097-2119 4.70e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.59  E-value: 4.70e-04
                           10        20
                   ....*....|....*....|...
gi 767939881  2097 YICEECGIRCKKPSMLKKHIRTH 2119
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2272-2634 1.20e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 1.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939881 2272 AQSDYNRKTLSPGKARQRAARDENDTIP-SVDTSRSPCHQMSVDYPESEEILRSSMAGKAVAITQ----------SPSSV 2340
Cdd:PHA03247 2582 VTSRARRPDAPPQSARPRAPVDDRGDPRgPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVppperprddpAPGRV 2661

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939881 2341 RLP--------PAAAEHSPQ---------TAAGMPSVASPHPDPQEQkqqitlQPTPGLPSPHTHLFSHLPLHSQQQSRT 2403
Cdd:PHA03247 2662 SRPrrarrlgrAAQASSPPQrprrraarpTVGSLTSLADPPPPPPTP------EPAPHALVSATPLPPGPAAARQASPAL 2735

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939881 2404 PYNMVP--VGGIHVVPAGLTYSTFVPLQAGPVQLTIPAVSVVHRTLGTHRNTVTEVSGTTNPAGVAELSSVVPCIPIGqi 2481
Cdd:PHA03247 2736 PAAPAPpaVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLA-- 2813

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939881 2482 RVPGLQNLSTPGLQSLPSLSMETvnivglANTNMAPQVHPPGLALN---AVGLQVLTANPSSQSSPAPQA--HIPglqIL 2556
Cdd:PHA03247 2814 PAAALPPAASPAGPLPPPTSAQP------TAPPPPPGPPPPSLPLGgsvAPGGDVRRRPPSRSPAAKPAApaRPP---VR 2884

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939881 2557 NIALPTLIPSVSQVAV--DAQGAPEMPASQSKACETQPKQTSVASANQvsrtESPQGLPTvqrenakkvlNPPAPAGDHA 2634
Cdd:PHA03247 2885 RLARPAVSRSTESFALppDQPERPPQPQAPPPPQPQPQPPPPPQPQPP----PPPPPRPQ----------PPLAPTTDPA 2950
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 2125-2146 1.35e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.05  E-value: 1.35e-03
                           10        20
                   ....*....|....*....|..
gi 767939881  2125 YHCTYCNFSFKTKGNLTKHMKS 2146
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRT 22
zf-C2H2_2 pfam12756
C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger ...
 2125-2190 3.03e-03

C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger domain.


Pssm-ID: 463690  Cd Length: 98  Bit Score: 39.19  E-value: 3.03e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767939881  2125 YHCTYCNFSFKTKGNLTKHMKSKAHSKkcvdlgvsvglIDEQDTEESDEKQRFsyersgYDLEESD 2190
Cdd:pfam12756   50 NECLYCGKQFKSLEALRQHMRDKGHCK-----------IPYESEEEWLEIAEF------YDFSSSY 98
ZnF_C2H2 smart00355
zinc finger;
2125-2146 5.16e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 36.67  E-value: 5.16e-03
                            10        20
                    ....*....|....*....|..
gi 767939881   2125 YHCTYCNFSFKTKGNLTKHMKS 2146
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRT 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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