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Conserved domains on  [gi|767940213|ref|XP_011512986|]
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fibrocystin isoform X7 [Homo sapiens]

Protein Classification

right-handed parallel beta-helix repeat-containing protein( domain architecture ID 11535905)

right-handed parallel beta-helix repeat-containing protein that may share some similarity with pectate lyases, similar to Bacteroides thetaiotaomicron alpha-1,3-galactosidase B that removes both branched alpha-1,3-linked galactose residues of blood group B antigens and linear alpha-1,3-linked galactose structures

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 1696-1812 4.80e-35

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


:

Pssm-ID: 462971  Cd Length: 121  Bit Score: 131.19  E-value: 4.80e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213  1696 SWFPERLPQDGDNVTVENGQLLLLDTNTSILNLLHIKgGKLIFMAPGPIELRAHAILVSdGGELRIGSEDKPFQGRAQIT 1775
Cdd:pfam10162    1 TWGGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQ-GTLIFDDDKNITLRARYILVQ-GGRLIIGSEDCPFQGKATIT 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 767940213  1776 LYGSSY--STPFFPYGVKFLAVRN-GTLSLHGSLPEVIVT 1812
Cdd:pfam10162   79 LHGRPEldDDDGPNYGSKVIGVRNgGTLELHGQPPTVTWT 118
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 2512-2635 1.61e-31

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


:

Pssm-ID: 462971  Cd Length: 121  Bit Score: 121.17  E-value: 1.61e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213  2512 WGGYNntIPGPGDDVLILPNRTVLVDTDLPFFKGLYVMGTLDFPVDRSNVLSVACMVIAGGELKVGTLENPLekEQKLLI 2591
Cdd:pfam10162    2 WGGGV--VPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQGTLIFDDDKNITLRARYILVQGGRLIIGSEDCPF--QGKATI 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 767940213  2592 LLRASEGvfCDRMNGIHIDPGTIGV--YGKVHLYSAYPKNSWTHLG 2635
Cdd:pfam10162   78 TLHGRPE--LDDDDGPNYGSKVIGVrnGGTLELHGQPPTVTWTKLA 121
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 960-1057 9.18e-14

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 69.41  E-value: 9.18e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213  960 EVFSIEPCCGSLLGGTILSISGIGFSRDPALVWVLVGNRSCDIVNLTEASIWCETLPAPQIPdagaptvPAAVEVWAGNr 1039
Cdd:cd00603     2 VITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPG-------EGPVEVTVDG- 73

                          90
                  ....*....|....*...
gi 767940213 1040 ffARGPSPSLVGKGFTFM 1057
Cdd:cd00603    74 --ANVSARVLSNTTFTYV 89
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 23-102 9.71e-13

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 66.32  E-value: 9.71e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213   23 EILSVFPETGSLGGRTNITITGDFFDNSA---QVTIAGIPCDIRHVSPRKIECTTRApgkdvrLTTPQPGNRGLLFEVGD 99
Cdd:cd00603     2 VITSISPSSGPLSGGTRLTITGSNLGSGSprvRVTVGGVPCKVLNVSSTEIVCRTPA------AATPGEGPVEVTVDGAN 75


                  ...
gi 767940213  100 AVE 102
Cdd:cd00603    76 VSA 78
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1152-1242 3.13e-12

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 65.17  E-value: 3.13e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213 1152 PRIMAIFPSQGSACGGTILTVRGLLLNSRRRSVRVDLsGPFTCVILSLGDHTILCQVSLEGDPLPGasfSLNVTVLVNGL 1231
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTV-GGVPCKVLNVSSTEIVCRTPAAATPGEG---PVEVTVDGANV 76

                          90
                  ....*....|.
gi 767940213 1232 tSECQGNCTLF 1242
Cdd:cd00603    77 -SARVLSNTTF 86
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 782-866 1.26e-09

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 57.46  E-value: 1.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213  782 PRLDMVEPSRAADIGGLWATIRGSSLEGVSL---ILFGSYSCAINVatSNSSRIQCKVPPRGKDG---RIVNVTVIRGDY 855
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPrvrVTVGGVPCKVLN--VSSTEIVCRTPAAATPGegpVEVTVDGANVSA 78

                          90
                  ....*....|.
gi 767940213  856 SAVLPRAFTYV 866
Cdd:cd00603    79 RVLSNTTFTYV 89
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 694-767 5.06e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 55.53  E-value: 5.06e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767940213   694 PCVHSVW-YSIDGDINLMIYITGTGFSGDSQFLQVTVNKTSCKVIFSNQTNVVCQTDLLPVGMHRILMLVRPSGL 767
Cdd:pfam01833    1 PVITSISpSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGI 75
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 871-955 9.18e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 55.15  E-value: 9.18e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213   871 PVIVTLSRNISNIAGGETLVIGVARLmNYTDLDVEVHVQDALAPVHTQSAWGLEVALPPLPAGLHRISVSINGVSIHSQG 950
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNF-GTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSP 79


                   ....*
gi 767940213   951 VDLHI 955
Cdd:pfam01833   80 LTFTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1249-1332 6.54e-08

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 52.45  E-value: 6.54e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213  1249 PVMDALSTNTS--GSLTTVLIRGQRLATTADEPMVFVDDQlPCNVTFFNASHVVCQTRDLAPGPHYLSVFYtRNGYACSG 1326
Cdd:pfam01833    1 PVITSISPSSGpaSGGTTITITGSNFGTDSSDLKVTIGGT-PCTVISVSSTTIVCTTPPGTSGLVNVSVTV-GGGGISSS 78


                   ....*.
gi 767940213  1327 NVSRHF 1332
Cdd:pfam01833   79 PLTFTY 84
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1336-1403 8.69e-07

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 49.76  E-value: 8.69e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767940213 1336 PQVFHYFPKNFSLHGGSLLTIEGTGL-RGQNTTSVYIDQQTCLTVNIGAELIRCIVPTGNGSVALEIEV 1403
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLgSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGEGPVEV 69
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 2765-2940 1.85e-06

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


:

Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 50.48  E-value: 1.85e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213  2765 SSVEFSNVSAGSwIISSTLHQSCGGGIHAAASHGVLLNDNIVFGTAGHGIDLEGQAY-TVTNNLvvlmtqpaWSTIWVAG 2843
Cdd:pfam13229    1 SGILLNGSSNAT-IKNNTISNNGGYGIYLRGSSNATIENNTITNNGGDGIEISGSSNnTISNNT--------ISNNGGGG 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213  2844 IKVNQVKDINLHGNVVAGSERLGFHIrghkCSSCELLWSDNVAHS-SLHGLHLYKESG---LDNCTrisgflAFKNFDYG 2919
Cdd:pfam13229   72 IALRGSSNNLIENNTISNNGGAGIYL----SDSSNNTIENNIIHNnGGSGIVIEDSSNnvtISNNT------VTNNKGAG 141

                          170       180
                   ....*....|....*....|.
gi 767940213  2920 amLHVENSveIENITLVDNTI 2940
Cdd:pfam13229  142 --ILIVGG--SSNNTVENNTF 158
NosD super family cl34609
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 1960-2111 1.00e-03

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


The actual alignment was detected with superfamily member COG3420:

Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 44.52  E-value: 1.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213 1960 SQVQLKGVQFQVLGQAFHKHLSSLTLVGAmRESFIQGCTVRNSFSrGLSMCGTLGLKVDSNVFYNIlghallvgtcTEMR 2039
Cdd:COG3420    78 DNVTVRGLTITGSGDSLTDDDAGIYVRGA-DNAVIENNRIENNLF-GIYLEGSDNNVIRNNTISGN----------RDLR 145

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767940213 2040 YISWEAIHGrkddWSGHGNIIRNNVIIQVSGaeglsnpemltpsGIYI-CSPTNVIEGNRVCGAGYGyfFHLM 2111
Cdd:COG3420   146 ADRGNGIHL----WNSPGNVIEGNTISGGRD-------------GIYLeFSDNNVIRNNTIRNLRYG--IHYM 199
 
Name Accession Description Interval E-value
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 1696-1812 4.80e-35

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 131.19  E-value: 4.80e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213  1696 SWFPERLPQDGDNVTVENGQLLLLDTNTSILNLLHIKgGKLIFMAPGPIELRAHAILVSdGGELRIGSEDKPFQGRAQIT 1775
Cdd:pfam10162    1 TWGGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQ-GTLIFDDDKNITLRARYILVQ-GGRLIIGSEDCPFQGKATIT 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 767940213  1776 LYGSSY--STPFFPYGVKFLAVRN-GTLSLHGSLPEVIVT 1812
Cdd:pfam10162   79 LHGRPEldDDDGPNYGSKVIGVRNgGTLELHGQPPTVTWT 118
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 2512-2635 1.61e-31

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 121.17  E-value: 1.61e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213  2512 WGGYNntIPGPGDDVLILPNRTVLVDTDLPFFKGLYVMGTLDFPVDRSNVLSVACMVIAGGELKVGTLENPLekEQKLLI 2591
Cdd:pfam10162    2 WGGGV--VPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQGTLIFDDDKNITLRARYILVQGGRLIIGSEDCPF--QGKATI 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 767940213  2592 LLRASEGvfCDRMNGIHIDPGTIGV--YGKVHLYSAYPKNSWTHLG 2635
Cdd:pfam10162   78 TLHGRPE--LDDDDGPNYGSKVIGVrnGGTLELHGQPPTVTWTKLA 121
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 960-1057 9.18e-14

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 69.41  E-value: 9.18e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213  960 EVFSIEPCCGSLLGGTILSISGIGFSRDPALVWVLVGNRSCDIVNLTEASIWCETLPAPQIPdagaptvPAAVEVWAGNr 1039
Cdd:cd00603     2 VITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPG-------EGPVEVTVDG- 73

                          90
                  ....*....|....*...
gi 767940213 1040 ffARGPSPSLVGKGFTFM 1057
Cdd:cd00603    74 --ANVSARVLSNTTFTYV 89
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 23-102 9.71e-13

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 66.32  E-value: 9.71e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213   23 EILSVFPETGSLGGRTNITITGDFFDNSA---QVTIAGIPCDIRHVSPRKIECTTRApgkdvrLTTPQPGNRGLLFEVGD 99
Cdd:cd00603     2 VITSISPSSGPLSGGTRLTITGSNLGSGSprvRVTVGGVPCKVLNVSSTEIVCRTPA------AATPGEGPVEVTVDGAN 75


                  ...
gi 767940213  100 AVE 102
Cdd:cd00603    76 VSA 78
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1152-1242 3.13e-12

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 65.17  E-value: 3.13e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213 1152 PRIMAIFPSQGSACGGTILTVRGLLLNSRRRSVRVDLsGPFTCVILSLGDHTILCQVSLEGDPLPGasfSLNVTVLVNGL 1231
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTV-GGVPCKVLNVSSTEIVCRTPAAATPGEG---PVEVTVDGANV 76

                          90
                  ....*....|.
gi 767940213 1232 tSECQGNCTLF 1242
Cdd:cd00603    77 -SARVLSNTTF 86
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 782-866 1.26e-09

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 57.46  E-value: 1.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213  782 PRLDMVEPSRAADIGGLWATIRGSSLEGVSL---ILFGSYSCAINVatSNSSRIQCKVPPRGKDG---RIVNVTVIRGDY 855
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPrvrVTVGGVPCKVLN--VSSTEIVCRTPAAATPGegpVEVTVDGANVSA 78

                          90
                  ....*....|.
gi 767940213  856 SAVLPRAFTYV 866
Cdd:cd00603    79 RVLSNTTFTYV 89
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1152-1230 2.90e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 56.30  E-value: 2.90e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767940213  1152 PRIMAIFPSQGSACGGTILTVRGLLLNSRRRSVRVDLSGpFTCVILSLGDHTILCQVSlegdplPGASFSLNVTVLVNG 1230
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGG-TPCTVISVSSTTIVCTTP------PGTSGLVNVSVTVGG 72
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 694-767 5.06e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 55.53  E-value: 5.06e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767940213   694 PCVHSVW-YSIDGDINLMIYITGTGFSGDSQFLQVTVNKTSCKVIFSNQTNVVCQTDLLPVGMHRILMLVRPSGL 767
Cdd:pfam01833    1 PVITSISpSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGI 75
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 871-955 9.18e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 55.15  E-value: 9.18e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213   871 PVIVTLSRNISNIAGGETLVIGVARLmNYTDLDVEVHVQDALAPVHTQSAWGLEVALPPLPAGLHRISVSINGVSIHSQG 950
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNF-GTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSP 79


                   ....*
gi 767940213   951 VDLHI 955
Cdd:pfam01833   80 LTFTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1249-1332 6.54e-08

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 52.45  E-value: 6.54e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213  1249 PVMDALSTNTS--GSLTTVLIRGQRLATTADEPMVFVDDQlPCNVTFFNASHVVCQTRDLAPGPHYLSVFYtRNGYACSG 1326
Cdd:pfam01833    1 PVITSISPSSGpaSGGTTITITGSNFGTDSSDLKVTIGGT-PCTVISVSSTTIVCTTPPGTSGLVNVSVTV-GGGGISSS 78


                   ....*.
gi 767940213  1327 NVSRHF 1332
Cdd:pfam01833   79 PLTFTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 24-84 4.35e-07

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 50.14  E-value: 4.35e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767940213    24 ILSVFPETGSLGGRTNITITGDFF---DNSAQVTIAGIPCDIRHVSPRKIECTTRA-PGKDVRLT 84
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGSNFgtdSSDLKVTIGGTPCTVISVSSTTIVCTTPPgTSGLVNVS 67
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1336-1403 8.69e-07

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 49.76  E-value: 8.69e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767940213 1336 PQVFHYFPKNFSLHGGSLLTIEGTGL-RGQNTTSVYIDQQTCLTVNIGAELIRCIVPTGNGSVALEIEV 1403
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLgSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGEGPVEV 69
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 2765-2940 1.85e-06

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 50.48  E-value: 1.85e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213  2765 SSVEFSNVSAGSwIISSTLHQSCGGGIHAAASHGVLLNDNIVFGTAGHGIDLEGQAY-TVTNNLvvlmtqpaWSTIWVAG 2843
Cdd:pfam13229    1 SGILLNGSSNAT-IKNNTISNNGGYGIYLRGSSNATIENNTITNNGGDGIEISGSSNnTISNNT--------ISNNGGGG 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213  2844 IKVNQVKDINLHGNVVAGSERLGFHIrghkCSSCELLWSDNVAHS-SLHGLHLYKESG---LDNCTrisgflAFKNFDYG 2919
Cdd:pfam13229   72 IALRGSSNNLIENNTISNNGGAGIYL----SDSSNNTIENNIIHNnGGSGIVIEDSSNnvtISNNT------VTNNKGAG 141

                          170       180
                   ....*....|....*....|.
gi 767940213  2920 amLHVENSveIENITLVDNTI 2940
Cdd:pfam13229  142 --ILIVGG--SSNNTVENNTF 158
IPT smart00429
ig-like, plexins, transcription factors;
23-74 2.14e-06

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 48.57  E-value: 2.14e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 767940213     23 EILSVFPETGSLGGRTNITITGDFFDNSAQVTI----AGIPCDIRHVSPRKIECTT 74
Cdd:smart00429    3 VITRISPTSGPVSGGTEITLCGKNLKSISVVFVevgvGEAPCTFSPSSSTAIVCKT 58
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1341-1405 1.23e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 46.29  E-value: 1.23e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767940213  1341 YFPKNFSLHGGSLLTIEGTGLR-GQNTTSVYIDQQTCLTVNIGAELIRCIVPTG-NGSVALEIEVDG 1405
Cdd:pfam01833    6 ISPSSGPASGGTTITITGSNFGtDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGtSGLVNVSVTVGG 72
IPT smart00429
ig-like, plexins, transcription factors;
960-1057 4.48e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 42.02  E-value: 4.48e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213    960 EVFSIEPCCGSLLGGTILSISGIGFSRDPALVWVL-VGNRSCDIVNLTEASIWCETLPAPQIPdagaptvpaaVEVWAGN 1038
Cdd:smart00429    3 VITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVgVGEAPCTFSPSSSTAIVCKTPPYHNIP----------GSVPVRT 72

                            90
                    ....*....|....*....
gi 767940213   1039 RFFARGPSPSLvGKGFTFM 1057
Cdd:smart00429   73 VGLRNGGVPSS-PQPFTYV 90
NosD COG3420
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 2780-2942 4.49e-04

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 45.68  E-value: 4.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213 2780 SSTLHQSCGGGIHAAASHGVLLNDNIVFGTAgHGIDLEGQAY-TVTNNLVVlmTQPAWSTIWVAGIKVNQVKDINLHGNV 2858
Cdd:COG3420    90 SGDSLTDDDAGIYVRGADNAVIENNRIENNL-FGIYLEGSDNnVIRNNTIS--GNRDLRADRGNGIHLWNSPGNVIEGNT 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213 2859 VAGSeRLGFHIrghkCSSCELLWSDNVAHSSLHGLHLYKESG--------LDNCT----------RISGFLAFKNFDYGA 2920
Cdd:COG3420   167 ISGG-RDGIYL----EFSDNNVIRNNTIRNLRYGIHYMYSNDnlvegntfRDNGAgialmyskgnTVRGNTILGNSGYGI 241

                         170       180
                  ....*....|....*....|..
gi 767940213 2921 MLHVENSVEIENITLVDNTIGL 2942
Cdd:COG3420   242 LLKESSDSVIEGNTISGNGKGI 263
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 963-1018 9.22e-04

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 40.89  E-value: 9.22e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 767940213   963 SIEPCCGSLLGGTILSISGIGFSRDPALVWVLVGNRSCDIVNLTEASIWCETLPAP 1018
Cdd:pfam01833    5 SISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGT 60
NosD COG3420
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 1960-2111 1.00e-03

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 44.52  E-value: 1.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213 1960 SQVQLKGVQFQVLGQAFHKHLSSLTLVGAmRESFIQGCTVRNSFSrGLSMCGTLGLKVDSNVFYNIlghallvgtcTEMR 2039
Cdd:COG3420    78 DNVTVRGLTITGSGDSLTDDDAGIYVRGA-DNAVIENNRIENNLF-GIYLEGSDNNVIRNNTISGN----------RDLR 145

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767940213 2040 YISWEAIHGrkddWSGHGNIIRNNVIIQVSGaeglsnpemltpsGIYI-CSPTNVIEGNRVCGAGYGyfFHLM 2111
Cdd:COG3420   146 ADRGNGIHL----WNSPGNVIEGNTISGGRD-------------GIYLeFSDNNVIRNNTIRNLRYG--IHYM 199
IPT smart00429
ig-like, plexins, transcription factors;
1152-1208 1.73e-03

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 40.10  E-value: 1.73e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 767940213   1152 PRIMAIFPSQGSACGGTILTVRGLLLNS-RRRSVRVDLSGPFtCVILSLGDHTILCQV 1208
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSiSVVFVEVGVGEAP-CTFSPSSSTAIVCKT 58
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 782-865 7.14e-03

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 38.20  E-value: 7.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213   782 PRLDMVEPSRAADIGGLWATIRGSSLEGVS---LILFGSYSCAINvaTSNSSRIQCKVPPRGKDGRIVNVTViRGDYSAV 858
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSsdlKVTIGGTPCTVI--SVSSTTIVCTTPPGTSGLVNVSVTV-GGGGISS 77


                   ....*..
gi 767940213   859 LPRAFTY 865
Cdd:pfam01833   78 SPLTFTY 84
 
Name Accession Description Interval E-value
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 1696-1812 4.80e-35

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 131.19  E-value: 4.80e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213  1696 SWFPERLPQDGDNVTVENGQLLLLDTNTSILNLLHIKgGKLIFMAPGPIELRAHAILVSdGGELRIGSEDKPFQGRAQIT 1775
Cdd:pfam10162    1 TWGGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQ-GTLIFDDDKNITLRARYILVQ-GGRLIIGSEDCPFQGKATIT 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 767940213  1776 LYGSSY--STPFFPYGVKFLAVRN-GTLSLHGSLPEVIVT 1812
Cdd:pfam10162   79 LHGRPEldDDDGPNYGSKVIGVRNgGTLELHGQPPTVTWT 118
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 2512-2635 1.61e-31

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 121.17  E-value: 1.61e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213  2512 WGGYNntIPGPGDDVLILPNRTVLVDTDLPFFKGLYVMGTLDFPVDRSNVLSVACMVIAGGELKVGTLENPLekEQKLLI 2591
Cdd:pfam10162    2 WGGGV--VPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQGTLIFDDDKNITLRARYILVQGGRLIIGSEDCPF--QGKATI 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 767940213  2592 LLRASEGvfCDRMNGIHIDPGTIGV--YGKVHLYSAYPKNSWTHLG 2635
Cdd:pfam10162   78 TLHGRPE--LDDDDGPNYGSKVIGVrnGGTLELHGQPPTVTWTKLA 121
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 960-1057 9.18e-14

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 69.41  E-value: 9.18e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213  960 EVFSIEPCCGSLLGGTILSISGIGFSRDPALVWVLVGNRSCDIVNLTEASIWCETLPAPQIPdagaptvPAAVEVWAGNr 1039
Cdd:cd00603     2 VITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPG-------EGPVEVTVDG- 73

                          90
                  ....*....|....*...
gi 767940213 1040 ffARGPSPSLVGKGFTFM 1057
Cdd:cd00603    74 --ANVSARVLSNTTFTYV 89
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 23-102 9.71e-13

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 66.32  E-value: 9.71e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213   23 EILSVFPETGSLGGRTNITITGDFFDNSA---QVTIAGIPCDIRHVSPRKIECTTRApgkdvrLTTPQPGNRGLLFEVGD 99
Cdd:cd00603     2 VITSISPSSGPLSGGTRLTITGSNLGSGSprvRVTVGGVPCKVLNVSSTEIVCRTPA------AATPGEGPVEVTVDGAN 75


                  ...
gi 767940213  100 AVE 102
Cdd:cd00603    76 VSA 78
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1152-1242 3.13e-12

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 65.17  E-value: 3.13e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213 1152 PRIMAIFPSQGSACGGTILTVRGLLLNSRRRSVRVDLsGPFTCVILSLGDHTILCQVSLEGDPLPGasfSLNVTVLVNGL 1231
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTV-GGVPCKVLNVSSTEIVCRTPAAATPGEG---PVEVTVDGANV 76

                          90
                  ....*....|.
gi 767940213 1232 tSECQGNCTLF 1242
Cdd:cd00603    77 -SARVLSNTTF 86
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1152-1242 1.36e-10

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 60.17  E-value: 1.36e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213 1152 PRIMAIFPSQGSACGGTILTVRGLLLNSRRRsVRVDLSGPFTCVILSLGDHTILCQVSLEGDPLPGasfslNVTVLVNGL 1231
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGSN-LRVTFGGGVPCSVLSVSSTAIVCTTPPYANPGPG-----PVEVTVDRG 74

                          90
                  ....*....|.
gi 767940213 1232 TSECQGNCTLF 1242
Cdd:cd00102    75 NGGITSSPLTF 85
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 782-866 1.26e-09

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 57.46  E-value: 1.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213  782 PRLDMVEPSRAADIGGLWATIRGSSLEGVSL---ILFGSYSCAINVatSNSSRIQCKVPPRGKDG---RIVNVTVIRGDY 855
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPrvrVTVGGVPCKVLN--VSSTEIVCRTPAAATPGegpVEVTVDGANVSA 78

                          90
                  ....*....|.
gi 767940213  856 SAVLPRAFTYV 866
Cdd:cd00603    79 RVLSNTTFTYV 89
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1152-1230 2.90e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 56.30  E-value: 2.90e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767940213  1152 PRIMAIFPSQGSACGGTILTVRGLLLNSRRRSVRVDLSGpFTCVILSLGDHTILCQVSlegdplPGASFSLNVTVLVNG 1230
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGG-TPCTVISVSSTTIVCTTP------PGTSGLVNVSVTVGG 72
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 23-76 2.90e-09

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 56.70  E-value: 2.90e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767940213   23 EILSVFPETGSLGGRTNITITGDFFDNSAQVTI---AGIPCDIRHVSPRKIECTTRA 76
Cdd:cd00102     2 VITSISPSSGPVSGGTEVTITGSNFGSGSNLRVtfgGGVPCSVLSVSSTAIVCTTPP 58
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 694-767 5.06e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 55.53  E-value: 5.06e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767940213   694 PCVHSVW-YSIDGDINLMIYITGTGFSGDSQFLQVTVNKTSCKVIFSNQTNVVCQTDLLPVGMHRILMLVRPSGL 767
Cdd:pfam01833    1 PVITSISpSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGI 75
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 871-955 9.18e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 55.15  E-value: 9.18e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213   871 PVIVTLSRNISNIAGGETLVIGVARLmNYTDLDVEVHVQDALAPVHTQSAWGLEVALPPLPAGLHRISVSINGVSIHSQG 950
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNF-GTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSP 79


                   ....*
gi 767940213   951 VDLHI 955
Cdd:pfam01833   80 LTFTY 84
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 960-1057 1.60e-08

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 54.39  E-value: 1.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213  960 EVFSIEPCCGSLLGGTILSISGIGFSRDPALVWVLVGNRSCDIVNLTEASIWCETLPAPQIPdagaptvPAAVEVWAGNR 1039
Cdd:cd00102     2 VITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTFGGGVPCSVLSVSSTAIVCTTPPYANPG-------PGPVEVTVDRG 74

                          90
                  ....*....|....*...
gi 767940213 1040 FFARGPSPslvgKGFTFM 1057
Cdd:cd00102    75 NGGITSSP----LTFTYV 88
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1249-1332 6.54e-08

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 52.45  E-value: 6.54e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213  1249 PVMDALSTNTS--GSLTTVLIRGQRLATTADEPMVFVDDQlPCNVTFFNASHVVCQTRDLAPGPHYLSVFYtRNGYACSG 1326
Cdd:pfam01833    1 PVITSISPSSGpaSGGTTITITGSNFGTDSSDLKVTIGGT-PCTVISVSSTTIVCTTPPGTSGLVNVSVTV-GGGGISSS 78


                   ....*.
gi 767940213  1327 NVSRHF 1332
Cdd:pfam01833   79 PLTFTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 24-84 4.35e-07

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 50.14  E-value: 4.35e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767940213    24 ILSVFPETGSLGGRTNITITGDFF---DNSAQVTIAGIPCDIRHVSPRKIECTTRA-PGKDVRLT 84
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGSNFgtdSSDLKVTIGGTPCTVISVSSTTIVCTTPPgTSGLVNVS 67
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 23-79 8.01e-07

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 49.62  E-value: 8.01e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767940213   23 EILSVFPETGSLGGRTNITITG-----DFFDNSAQVTIAGIPCDI---RHVSPRKIECTTRAPGK 79
Cdd:cd01180     2 VITEFFPLSGPLEGGTRLTICGsnlglRKNDVRHGVRVGGVPCNPeppEYSSSEKIVCTTGPAGN 66
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1336-1403 8.69e-07

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 49.76  E-value: 8.69e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767940213 1336 PQVFHYFPKNFSLHGGSLLTIEGTGL-RGQNTTSVYIDQQTCLTVNIGAELIRCIVPTGNGSVALEIEV 1403
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLgSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGEGPVEV 69
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 782-867 1.14e-06

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 49.38  E-value: 1.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213  782 PRLDMVEPSRAADIGGLWATIRGSSLEGVSLI---LFGSYSCAINVatSNSSRIQCKVPPRGKDGRI-VNVTVIRGDYSA 857
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLrvtFGGGVPCSVLS--VSSTAIVCTTPPYANPGPGpVEVTVDRGNGGI 78

                          90
                  ....*....|.
gi 767940213  858 VL-PRAFTYVS 867
Cdd:cd00102    79 TSsPLTFTYVP 89
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 24-76 1.82e-06

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 48.37  E-value: 1.82e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767940213   24 ILSVFPETGSLGGRTNITITGDFFD--NSAQVTIAGIPCDIRHVSPRKIECTTRA 76
Cdd:cd01179     3 ITSLSPSYGPQSGGTRLTITGKHLNagSSVRVTVGGQPCKILSVSSSQIVCLTPP 57
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 2765-2940 1.85e-06

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 50.48  E-value: 1.85e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213  2765 SSVEFSNVSAGSwIISSTLHQSCGGGIHAAASHGVLLNDNIVFGTAGHGIDLEGQAY-TVTNNLvvlmtqpaWSTIWVAG 2843
Cdd:pfam13229    1 SGILLNGSSNAT-IKNNTISNNGGYGIYLRGSSNATIENNTITNNGGDGIEISGSSNnTISNNT--------ISNNGGGG 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213  2844 IKVNQVKDINLHGNVVAGSERLGFHIrghkCSSCELLWSDNVAHS-SLHGLHLYKESG---LDNCTrisgflAFKNFDYG 2919
Cdd:pfam13229   72 IALRGSSNNLIENNTISNNGGAGIYL----SDSSNNTIENNIIHNnGGSGIVIEDSSNnvtISNNT------VTNNKGAG 141

                          170       180
                   ....*....|....*....|.
gi 767940213  2920 amLHVENSveIENITLVDNTI 2940
Cdd:pfam13229  142 --ILIVGG--SSNNTVENNTF 158
IPT smart00429
ig-like, plexins, transcription factors;
23-74 2.14e-06

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 48.57  E-value: 2.14e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 767940213     23 EILSVFPETGSLGGRTNITITGDFFDNSAQVTI----AGIPCDIRHVSPRKIECTT 74
Cdd:smart00429    3 VITRISPTSGPVSGGTEITLCGKNLKSISVVFVevgvGEAPCTFSPSSSTAIVCKT 58
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1341-1405 1.23e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 46.29  E-value: 1.23e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767940213  1341 YFPKNFSLHGGSLLTIEGTGLR-GQNTTSVYIDQQTCLTVNIGAELIRCIVPTG-NGSVALEIEVDG 1405
Cdd:pfam01833    6 ISPSSGPASGGTTITITGSNFGtDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGtSGLVNVSVTVGG 72
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1336-1403 5.73e-05

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 44.37  E-value: 5.73e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767940213 1336 PQVFHYFPKNFSLHGGSLLTIEGTGLRGQNTTSVYI-DQQTCLTVNIGAELIRCIVPTGNGSVALEIEV 1403
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTFgGGVPCSVLSVSSTAIVCTTPPYANPGPGPVEV 69
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 960-1057 7.70e-05

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 44.23  E-value: 7.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213  960 EVFSIEPCCGSLLGGTILSISGIGFSRDPALVW--VLVGNRSCdIVNLTEASIW----CETlpapqiPDAGAPTVPAAVE 1033
Cdd:cd01180     2 VITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRhgVRVGGVPC-NPEPPEYSSSekivCTT------GPAGNPVFNGPVE 74

                          90       100
                  ....*....|....*....|....
gi 767940213 1034 VWAGNRFFaRGPSPslvgKGFTFM 1057
Cdd:cd01180    75 VTVGHGSF-RTESS----EGFSFV 93
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1350-1405 1.79e-04

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 42.98  E-value: 1.79e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 767940213 1350 GGSLLTIEGTGLRGQNTTSVYIDQQTCLTVNIGAELIRCIVP--TGNGSVALEIEVDG 1405
Cdd:cd01179    15 GGTRLTITGKHLNAGSSVRVTVGGQPCKILSVSSSQIVCLTPpsASPGEAPVKVLIDG 72
IPT smart00429
ig-like, plexins, transcription factors;
960-1057 4.48e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 42.02  E-value: 4.48e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213    960 EVFSIEPCCGSLLGGTILSISGIGFSRDPALVWVL-VGNRSCDIVNLTEASIWCETLPAPQIPdagaptvpaaVEVWAGN 1038
Cdd:smart00429    3 VITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVgVGEAPCTFSPSSSTAIVCKTPPYHNIP----------GSVPVRT 72

                            90
                    ....*....|....*....
gi 767940213   1039 RFFARGPSPSLvGKGFTFM 1057
Cdd:smart00429   73 VGLRNGGVPSS-PQPFTYV 90
NosD COG3420
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 2780-2942 4.49e-04

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 45.68  E-value: 4.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213 2780 SSTLHQSCGGGIHAAASHGVLLNDNIVFGTAgHGIDLEGQAY-TVTNNLVVlmTQPAWSTIWVAGIKVNQVKDINLHGNV 2858
Cdd:COG3420    90 SGDSLTDDDAGIYVRGADNAVIENNRIENNL-FGIYLEGSDNnVIRNNTIS--GNRDLRADRGNGIHLWNSPGNVIEGNT 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213 2859 VAGSeRLGFHIrghkCSSCELLWSDNVAHSSLHGLHLYKESG--------LDNCT----------RISGFLAFKNFDYGA 2920
Cdd:COG3420   167 ISGG-RDGIYL----EFSDNNVIRNNTIRNLRYGIHYMYSNDnlvegntfRDNGAgialmyskgnTVRGNTILGNSGYGI 241

                         170       180
                  ....*....|....*....|..
gi 767940213 2921 MLHVENSVEIENITLVDNTIGL 2942
Cdd:COG3420   242 LLKESSDSVIEGNTISGNGKGI 263
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 963-1018 9.22e-04

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 40.89  E-value: 9.22e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 767940213   963 SIEPCCGSLLGGTILSISGIGFSRDPALVWVLVGNRSCDIVNLTEASIWCETLPAP 1018
Cdd:pfam01833    5 SISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGT 60
NosD COG3420
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 1960-2111 1.00e-03

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 44.52  E-value: 1.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213 1960 SQVQLKGVQFQVLGQAFHKHLSSLTLVGAmRESFIQGCTVRNSFSrGLSMCGTLGLKVDSNVFYNIlghallvgtcTEMR 2039
Cdd:COG3420    78 DNVTVRGLTITGSGDSLTDDDAGIYVRGA-DNAVIENNRIENNLF-GIYLEGSDNNVIRNNTISGN----------RDLR 145

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767940213 2040 YISWEAIHGrkddWSGHGNIIRNNVIIQVSGaeglsnpemltpsGIYI-CSPTNVIEGNRVCGAGYGyfFHLM 2111
Cdd:COG3420   146 ADRGNGIHL----WNSPGNVIEGNTISGGRD-------------GIYLeFSDNNVIRNNTIRNLRYG--IHYM 199
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 782-866 1.45e-03

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 40.38  E-value: 1.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213  782 PRLDMVEPSRAADIGGLWATIRGSSLeGVSL------ILFGSYSCAINVAT-SNSSRIQCKVPPRGKDGR--IVNVTVIR 852
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGSNL-GLRKndvrhgVRVGGVPCNPEPPEySSSEKIVCTTGPAGNPVFngPVEVTVGH 79

                          90
                  ....*....|....
gi 767940213  853 GDYSAVLPRAFTYV 866
Cdd:cd01180    80 GSFRTESSEGFSFV 93
IPT smart00429
ig-like, plexins, transcription factors;
1152-1208 1.73e-03

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 40.10  E-value: 1.73e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 767940213   1152 PRIMAIFPSQGSACGGTILTVRGLLLNS-RRRSVRVDLSGPFtCVILSLGDHTILCQV 1208
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSiSVVFVEVGVGEAP-CTFSPSSSTAIVCKT 58
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 961-1038 1.93e-03

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 39.90  E-value: 1.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213  961 VFSIEPCCGSLLGGTILSISG----IGFSRDpalvwVLVGNRSCDIVNLTEASIWCETLPAPQIPdagaptvPAAVEVWA 1036
Cdd:cd01179     3 ITSLSPSYGPQSGGTRLTITGkhlnAGSSVR-----VTVGGQPCKILSVSSSQIVCLTPPSASPG-------EAPVKVLI 70


                  ..
gi 767940213 1037 GN 1038
Cdd:cd01179    71 DG 72
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1152-1230 2.88e-03

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 39.51  E-value: 2.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213 1152 PRIMAIFPSQGSACGGTILTVRGLLLNS-RRRSVRVdlsGPFTCVILSLGDHTILCQVSLEGDPLPGasfslNVTVLVNG 1230
Cdd:cd01179     1 PSITSLSPSYGPQSGGTRLTITGKHLNAgSSVRVTV---GGQPCKILSVSSSQIVCLTPPSASPGEA-----PVKVLIDG 72
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 2754-2872 5.76e-03

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 40.47  E-value: 5.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213  2754 VEIQNFGSPLYSSVEFSNV---------SAGSWIISSTLHQSCGGGIHAAASHGVLLNDNIVFGTAGHGIDLEGQAY-TV 2823
Cdd:pfam13229   26 IYLRGSSNATIENNTITNNggdgieisgSSNNTISNNTISNNGGGGIALRGSSNNLIENNTISNNGGAGIYLSDSSNnTI 105

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 767940213  2824 TNNLVVLMTQpawstiwvAGIKVNQVKD-INLHGNVVAGSERLGFHIRGH 2872
Cdd:pfam13229  106 ENNIIHNNGG--------SGIVIEDSSNnVTISNNTVTNNKGAGILIVGG 147
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1152-1225 6.22e-03

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 38.84  E-value: 6.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213 1152 PRIMAIFPSQGSACGGTILTVRG----LLLNSRRRSVRVdlsGPFTCVILSLGDHT---ILCQVSLEGDPLPGASFSLNV 1224
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGsnlgLRKNDVRHGVRV---GGVPCNPEPPEYSSsekIVCTTGPAGNPVFNGPVEVTV 77


                  .
gi 767940213 1225 T 1225
Cdd:cd01180    78 G 78
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1152-1216 6.64e-03

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238586  Cd Length: 99  Bit Score: 38.94  E-value: 6.64e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767940213 1152 PRIMAIFPSQGSACGGTILTVRGLLLNS-RRRSVRVDLSGPFT--CVILSlgDHTILCQV-SLEGDPLP 1216
Cdd:cd01181     1 PTITRIEPEWSFLSGGTPITVTGTNLNTvQEPRIRVKYGGVEKtsCKVRN--STLMTCPApSLALLNRS 67
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 782-865 7.14e-03

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 38.20  E-value: 7.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940213   782 PRLDMVEPSRAADIGGLWATIRGSSLEGVS---LILFGSYSCAINvaTSNSSRIQCKVPPRGKDGRIVNVTViRGDYSAV 858
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSsdlKVTIGGTPCTVI--SVSSTTIVCTTPPGTSGLVNVSVTV-GGGGISS 77


                   ....*..
gi 767940213   859 LPRAFTY 865
Cdd:pfam01833   78 SPLTFTY 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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