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Conserved domains on  [gi|767940491|ref|XP_011513103|]
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solute carrier family 22 member 23 isoform X1 [Homo sapiens]

Protein Classification

solute carrier family 22 member 23( domain architecture ID 13024574)

solute carrier family 22 member 23 (SLC22A23) belongs to a family of organic ion transporters that are responsible for the absorption or excretion of many drugs, xenobiotics and endogenous compounds in a variety of tissues

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_SLC22A23 cd17444
Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier ...
 192-629 0e+00

Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier family 22, member 23 (SLC22A23) is an orphan member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It is abundantly expressed in brain and is also found in liver. Single-nucleotide polymorphisms in SLC22A23 are associated with inflammatory bowel disease (IBD) in a Canadian white population. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A23 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 341002 [Multi-domain]  Cd Length: 364  Bit Score: 615.32  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 192 GDNASNCDCRAWDYGIRAGLVQNVVSKccqqqetgalpwdtdtkrwrpelnWDLVCDNAWKVHIAKFSLLVGLIFGYLIT 271
Cdd:cd17444    1 TENASSCQCTERDYRIRAGLVQNIVSK------------------------WDLVCDSSWKVHIAKFSLLVGLIFGYLIT 56

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 272 GCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMA 351
Cdd:cd17444   57 GCLADWFGRRPVLLFSVVFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILSLYALRIELCPPGHRFMITMVASFIAMA 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 352 GQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPeslrwlmatqqfesakrlilhftqknrmnpegdikgvipelek 431
Cdd:cd17444  137 GQFLMPGLAALCRDWQVLQAVIICPFLLMLSYWCIFP------------------------------------------- 173

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 432 elsrrpkkvcivkvvgtrnlwKNIVVLCVNSLTGYGIHHCFARSMMGHEVKVPLLENFYADYYTTASIALVSCLAMCVVV 511
Cdd:cd17444  174 ---------------------KNIVVLCVNSLTGYGIHHCFAKSMMDHEMKGSFLHNFYAEYYTMAVIALASCLAMCPVV 232

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 512 RFLGRRGGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVI 591
Cdd:cd17444  233 GFLGRRGGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGMSDEVKDKFSVTFSIVGMFSSHAVGSLSVFFCAEITPTVI 312

                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 767940491 592 RCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHHIIFA 629
Cdd:cd17444  313 RGGGLGLVLASAGFGMLTAPIMELHNQKGYFLHHIIFA 350
 
Name Accession Description Interval E-value
MFS_SLC22A23 cd17444
Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier ...
 192-629 0e+00

Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier family 22, member 23 (SLC22A23) is an orphan member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It is abundantly expressed in brain and is also found in liver. Single-nucleotide polymorphisms in SLC22A23 are associated with inflammatory bowel disease (IBD) in a Canadian white population. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A23 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341002 [Multi-domain]  Cd Length: 364  Bit Score: 615.32  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 192 GDNASNCDCRAWDYGIRAGLVQNVVSKccqqqetgalpwdtdtkrwrpelnWDLVCDNAWKVHIAKFSLLVGLIFGYLIT 271
Cdd:cd17444    1 TENASSCQCTERDYRIRAGLVQNIVSK------------------------WDLVCDSSWKVHIAKFSLLVGLIFGYLIT 56

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 272 GCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMA 351
Cdd:cd17444   57 GCLADWFGRRPVLLFSVVFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILSLYALRIELCPPGHRFMITMVASFIAMA 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 352 GQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPeslrwlmatqqfesakrlilhftqknrmnpegdikgvipelek 431
Cdd:cd17444  137 GQFLMPGLAALCRDWQVLQAVIICPFLLMLSYWCIFP------------------------------------------- 173

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 432 elsrrpkkvcivkvvgtrnlwKNIVVLCVNSLTGYGIHHCFARSMMGHEVKVPLLENFYADYYTTASIALVSCLAMCVVV 511
Cdd:cd17444  174 ---------------------KNIVVLCVNSLTGYGIHHCFAKSMMDHEMKGSFLHNFYAEYYTMAVIALASCLAMCPVV 232

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 512 RFLGRRGGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVI 591
Cdd:cd17444  233 GFLGRRGGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGMSDEVKDKFSVTFSIVGMFSSHAVGSLSVFFCAEITPTVI 312

                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 767940491 592 RCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHHIIFA 629
Cdd:cd17444  313 RGGGLGLVLASAGFGMLTAPIMELHNQKGYFLHHIIFA 350
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 243-652 5.80e-42

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 159.80  E-value: 5.80e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491  243 WDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGII 322
Cdd:TIGR00898 119 WDLVCEDAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIW 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491  323 LTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFES 402
Cdd:TIGR00898 199 VQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEE 278

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491  403 AKRLILHFTQKNRMNPEGDIKgvIPELEKELSRRPKKVCIVKVVGTRNL-WKNIVVLCV---NSLTGYGIhhcfarsMMG 478
Cdd:TIGR00898 279 ALKILQRIAKINGKKLPAEVL--SLSLEKDLSSSKKQYSFLDLFRTPNLrKTTLCLMMLwftTAFSYYGL-------VLD 349

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491  479 HEVkvpLLENFYADYYTTASIALVSCLAMCVVVRFLGRR----------GGLLLFMILTALASLLQLGLLNLIGKYSqhp 548
Cdd:TIGR00898 350 LGN---LGGNIYLDLFISGLVELPAKLITLLLIDRLGRRytmaaslllaGVALLLLLFVPVDLYFLRTALAVLGKFG--- 423

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491  549 dsgmsdsvkdkFSIAFSIVGMFAshavgslsvffcAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHHIIF 628
Cdd:TIGR00898 424 -----------ITSAFQMVYLYT------------AELYPTVVRNLGVGVCSTMARVGSIISPFLVYLGEKWLFLPLVLF 480

                         410       420
                  ....*....|....*....|....
gi 767940491  629 ACCTLICIICILLLPESRDQNLPE 652
Cdd:TIGR00898 481 GGLALLAGILTLFLPETKGVPLPE 504
Sugar_tr pfam00083
Sugar (and other) transporter;
259-629 8.75e-15

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 77.31  E-value: 8.75e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491  259 SLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTL---RFFEGFCLAGIILTLYALRIELCPP 335
Cdd:pfam00083  54 IFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVYQLivgRVLVGIGVGGASVLAPMYISEIAPK 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491  336 GKR-FMITMVASFVAMaGQFLMPGLA---ALCRD---WQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLIl 408
Cdd:pfam00083 134 KLRgALGSLYQLAITF-GILLAYIFGlglNKTSNsdgWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVL- 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491  409 hftqKNRMNPEGDIKGVIPELEK-ELSRRPKKVCIVKVVGTRNLWKNIVVLCV----------NSLTGYGihhcfarSMM 477
Cdd:pfam00083 212 ----AKLRGVPDVDRELDEIKDSlEAGQEAEKASWKELFSTKTRRQRLLIGVMlqifqqltgiNAIFYYS-------TTI 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491  478 GHEVKVPllenfyADYYTTASIALVSCLAMCV---VVRFLGRRgGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGmsd 554
Cdd:pfam00083 281 FENLGLS------DSFLVTIIVGVVNFVFTFIaifLVDRFGRR-PLLLLGAAGMAICFVILGIVALLGVSKSDWAGI--- 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491  555 svkdkFSIAFsIVGMFASHAVGSLSVFF--CAEITPTVIRCGGLGLVLAS---AGF--GMLTAPIIELHNQKGYFlhhII 627
Cdd:pfam00083 351 -----VAIVF-IALFIAFFAMGWGPVPWviVSELFPLSVRSKAMALATAAnwlANFliGFLFPIITDAIGLGYTF---FI 421


                  ..
gi 767940491  628 FA 629
Cdd:pfam00083 422 FA 423
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 261-408 5.19e-12

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 67.14  E-value: 5.19e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 261 LVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFM 340
Cdd:COG0477   59 LLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGR 138

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767940491 341 ITMVASFVAMAGQFLMPGLAALCRD---WQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLIL 408
Cdd:COG0477  139 ALGLWGAAIGLGLALGPLLGGLLVAalgWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLA 209
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
263-356 2.29e-05

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 47.22  E-value: 2.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 263 GLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGK--RFM 340
Cdd:PRK11102  38 GFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAAASVVINALMRDMFPKEEfsRMM 117

                         90       100
                 ....*....|....*....|..
gi 767940491 341 -----ITMVASFVA-MAGQFLM 356
Cdd:PRK11102 118 sfvtlVMTIAPLLApIIGGWLL 139
 
Name Accession Description Interval E-value
MFS_SLC22A23 cd17444
Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier ...
 192-629 0e+00

Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier family 22, member 23 (SLC22A23) is an orphan member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It is abundantly expressed in brain and is also found in liver. Single-nucleotide polymorphisms in SLC22A23 are associated with inflammatory bowel disease (IBD) in a Canadian white population. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A23 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341002 [Multi-domain]  Cd Length: 364  Bit Score: 615.32  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 192 GDNASNCDCRAWDYGIRAGLVQNVVSKccqqqetgalpwdtdtkrwrpelnWDLVCDNAWKVHIAKFSLLVGLIFGYLIT 271
Cdd:cd17444    1 TENASSCQCTERDYRIRAGLVQNIVSK------------------------WDLVCDSSWKVHIAKFSLLVGLIFGYLIT 56

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 272 GCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMA 351
Cdd:cd17444   57 GCLADWFGRRPVLLFSVVFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILSLYALRIELCPPGHRFMITMVASFIAMA 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 352 GQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPeslrwlmatqqfesakrlilhftqknrmnpegdikgvipelek 431
Cdd:cd17444  137 GQFLMPGLAALCRDWQVLQAVIICPFLLMLSYWCIFP------------------------------------------- 173

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 432 elsrrpkkvcivkvvgtrnlwKNIVVLCVNSLTGYGIHHCFARSMMGHEVKVPLLENFYADYYTTASIALVSCLAMCVVV 511
Cdd:cd17444  174 ---------------------KNIVVLCVNSLTGYGIHHCFAKSMMDHEMKGSFLHNFYAEYYTMAVIALASCLAMCPVV 232

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 512 RFLGRRGGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVI 591
Cdd:cd17444  233 GFLGRRGGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGMSDEVKDKFSVTFSIVGMFSSHAVGSLSVFFCAEITPTVI 312

                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 767940491 592 RCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHHIIFA 629
Cdd:cd17444  313 RGGGLGLVLASAGFGMLTAPIMELHNQKGYFLHHIIFA 350
MFS_SLC22A17_like cd17373
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ...
 203-629 3.74e-166

Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340931 [Multi-domain]  Cd Length: 348  Bit Score: 481.25  E-value: 3.74e-166
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 203 WDYGIRAGLVQNVVSKccqqqetgalpwdtdtkrwrpelnWDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIADWVGRRP 282
Cdd:cd17373    1 WDYGIRAGLVQNAVSK------------------------WDLVCDNGWKVHLEQFSLLLGLIFGYLILGCIADRFGRRP 56

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 283 VLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAAL 362
Cdd:cd17373   57 VLLFSLILILIFGLTVALAVSVTMFSTLRFLEGFCLAGIILTLYLLRLELCDPGKRLMITMVASLVAVAGQFLMPGLAAL 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 363 CRDWQVLQALIICPFLLMLLYWSIFPeslrwlmatqqfesakrlilhftqknrmnpegdikgvipelekelsrrpkkvci 442
Cdd:cd17373  137 CRDWRVLQALIICPFLLMLLYWSIFP------------------------------------------------------ 162

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 443 vkvvgtrnlwKNIVVLCVNSLTGYGIHHCFARSMMGHEVkvpllENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLL 522
Cdd:cd17373  163 ----------KNILILGFNSLTGYGIRHCFARSMMGHEP-----ENFYLDYYLTAGIAAVACVFLCVTVDFLGRRGGLLL 227

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 523 FMILTALASLLQLGLLNLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLAS 602
Cdd:cd17373  228 FMILTGLASLLLLGLLNLIGKYSQHPDSGMSDSVKDKFSIAFSVLGLFASHAVGSLSVLFAAEVTPTVIRGGGLGLVLAS 307

                        410       420
                 ....*....|....*....|....*..
gi 767940491 603 AGFGMLTAPIIELHNQKGYFLHHIIFA 629
Cdd:cd17373  308 GGLGMLTGPIIELHNQKGYFLQHVVFA 334
MFS_SLC22A31 cd17443
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ...
 243-629 1.02e-75

Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341001 [Multi-domain]  Cd Length: 343  Bit Score: 247.38  E-value: 1.02e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 243 WDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGII 322
Cdd:cd17443   28 WNLVCDDGWKVPLEKISYLLGWLLGYIILGAGCDRLGRRAAFVLSLVLATLLGVSVALSASPPTFLVLRLLQGGTLAGVF 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 323 LTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSifpeslrwlmatqqFES 402
Cdd:cd17443  108 LSLYIARLELCDPSHRLMVSMGAGFFSVAGELLLPGLAVLCRDWRVLQGVGTLPLLLLLLYWC--------------FPS 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 403 AKRLILHFTqknrmnpegdikgvipelekelsrrpkkvcivkvvgtrnlwknivvlcvnSLTGYGIHHCFARSMMghevk 482
Cdd:cd17443  174 RNGLILGFT--------------------------------------------------AFIGGGIRYCFARNLA----- 198

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 483 vPLLENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLgllnligkysqhpdsGMSDSVKDKFSI 562
Cdd:cd17443  199 -PFVPTFYLPYFLQAGLEALACIFLCLTVDRCGRRGVLLLGTIVTGLSSLLLL---------------ALTQYLHGGLVL 262

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767940491 563 AFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHHIIFA 629
Cdd:cd17443  263 VLSVVGLLASHAVSMLSMFFAAEVLPTVIRGAGLGLIMGAGFLGRAAGPLMELQNKQGYFLHHVVFA 329
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
 200-629 1.80e-67

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 225.42  E-value: 1.80e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 200 CRAWDYGIRAGLVQNVVSKccqqqetgalpwdtdtkrwrpelnWDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIADWVG 279
Cdd:cd17445    9 DAGWNYTGLPGLTNNIVTE------------------------WDLVCSRYWLVPLEQVCFILGFASGYLCLGYTADRLG 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 280 RRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGL 359
Cdd:cd17445   65 RRRTLLLSLTLAVPFGVLVAVAASPSLFMAMRFLLGAALAGVYLTLYLTRLELCDPPQRLLVAMAGGLTMVGGHFLLLGL 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 360 AALCRDWQVLQALIICPFLLMLLYwsifpeslrwlmatqqfesakrlilhftqknrmnpegDIKGVipelekelsrrpkk 439
Cdd:cd17445  145 ALGCGSWRVLQGTITAPLSLFLCY-------------------------------------GCPGV-------------- 173

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 440 vcivkvvgtrnlwKNIVVLCVNSLTGYGIHHCFarSMMGHEVKvPLLENFYADYYTTASIALVSCLAMCVVVRFLGRRGG 519
Cdd:cd17445  174 -------------KNLLILGFTTFIAHAISHCY--QSFSDDVR-GTPSTFYLSYLLSTGTAGLACLFLCATVDRFGRRGI 237

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 520 LLLFMILTALASLLQLgllnligkysqhpdsGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLV 599
Cdd:cd17445  238 LLLAMTLTGIASLILL---------------GLMDYLNDAAIKTFSILGLFSSQAAASLSILFAAEVIPTVIRGSGLGLI 302

                        410       420       430
                 ....*....|....*....|....*....|
gi 767940491 600 LASAGFGMLTAPIIELHNQKGYFLHHIIFA 629
Cdd:cd17445  303 MALGSLGGLSSPLMRLRNQHGYFLHHVVLA 332
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 243-652 5.80e-42

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 159.80  E-value: 5.80e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491  243 WDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGII 322
Cdd:TIGR00898 119 WDLVCEDAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIW 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491  323 LTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFES 402
Cdd:TIGR00898 199 VQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEE 278

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491  403 AKRLILHFTQKNRMNPEGDIKgvIPELEKELSRRPKKVCIVKVVGTRNL-WKNIVVLCV---NSLTGYGIhhcfarsMMG 478
Cdd:TIGR00898 279 ALKILQRIAKINGKKLPAEVL--SLSLEKDLSSSKKQYSFLDLFRTPNLrKTTLCLMMLwftTAFSYYGL-------VLD 349

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491  479 HEVkvpLLENFYADYYTTASIALVSCLAMCVVVRFLGRR----------GGLLLFMILTALASLLQLGLLNLIGKYSqhp 548
Cdd:TIGR00898 350 LGN---LGGNIYLDLFISGLVELPAKLITLLLIDRLGRRytmaaslllaGVALLLLLFVPVDLYFLRTALAVLGKFG--- 423

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491  549 dsgmsdsvkdkFSIAFSIVGMFAshavgslsvffcAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHHIIF 628
Cdd:TIGR00898 424 -----------ITSAFQMVYLYT------------AELYPTVVRNLGVGVCSTMARVGSIISPFLVYLGEKWLFLPLVLF 480

                         410       420
                  ....*....|....*....|....
gi 767940491  629 ACCTLICIICILLLPESRDQNLPE 652
Cdd:TIGR00898 481 GGLALLAGILTLFLPETKGVPLPE 504
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 243-629 5.25e-41

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 152.73  E-value: 5.25e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 243 WDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGII 322
Cdd:cd17317   17 WDLVCDRDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIF 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 323 LTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWsifpeslrWLMatqqfes 402
Cdd:cd17317   97 TVGFVLGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLLL--------WWL------- 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 403 akrlilhftqknrmnpegdikgvipelekelsrrPKKVCIVkvvgtrnlwknIVVLCVNSLTGYGIhhcfarSMMGHEvk 482
Cdd:cd17317  162 ----------------------------------PRRTIIV-----------GLIWFVTSLVYYGL------SLNSSN-- 188

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 483 vpLLENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTAlasllqlGLLNLIGKYSQHPDSgmsdsvkdkFSI 562
Cdd:cd17317  189 --LGGNLYLNFFLSGLVEIPAYFLALLLLDRLGRRWTLSGSLLLAG-------LACLVTALLPDDENT---------LAL 250

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767940491 563 AFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHHIIFA 629
Cdd:cd17317  251 TLALVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIVLLGKIGPLLPLIIFG 317
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 243-628 4.40e-25

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 106.99  E-value: 4.40e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 243 WDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGII 322
Cdd:cd17374   27 WDLVCESQSLKSVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGIS 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 323 LTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYwsifpesLRWLmatqqfes 402
Cdd:cd17374  107 INTLILGTEWTTPRHRALAITLTSCFFSIGQMLLAGLAYAIRDWRLLQLVVSVPFFLFFLY-------SWWL-------- 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 403 akrlilhftqknrmnpegdikgvipelekelsrrPKKVCIvkvvgtrnlwkNIVVLCVNSLTGYGIhhcfarsMMGhevk 482
Cdd:cd17374  172 ----------------------------------PKRTLI-----------LSFVWFANSFSYYGL-------SLD---- 195

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 483 vplLENFYADYYTT-----ASIALVSCLAMcVVVRFLGRRGGLLLFMILTAlaslLQLGLLNLIGKYSQHpdsgmsdsvk 557
Cdd:cd17374  196 ---LQHLGLNVFLLqflfgAVEVPARCLAL-FLLNHMGRRISQAVLLLLAG----LCILANIFVPQEMQT---------- 257

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767940491 558 dkFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHHIIF 628
Cdd:cd17374  258 --LRTVLAVLGKGSSAAAFTISYVYTAELFPTVLRQTGMGLNSMFARIGGILAPLIMLLGVYSPLLPMIIY 326
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
 243-388 3.47e-22

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 98.26  E-value: 3.47e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 243 WDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGII 322
Cdd:cd17446   25 WDLVCNHRALRQLAQSIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMALSGIV 104

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767940491 323 LTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFP 388
Cdd:cd17446  105 LNSVSLNVEWMPTRVRAVVGTLLGYCYTLGQLILAGVAYAIRDWRWLQLAVSLPFFIFFLYSWWFP 170
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 243-395 2.97e-20

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 92.80  E-value: 2.97e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 243 WDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGII 322
Cdd:cd17379   25 FNLVCEDAWKLDLFQSSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGW 104

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767940491 323 LTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLM 395
Cdd:cd17379  105 MTGYVLVTEFVGSKYRRTVGIVYQMFFTLGLLILPGIAYFIPHWRWLQLAVTLPNFLFLLYYWFIPKHTFILM 177
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
 243-629 1.40e-19

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 90.88  E-value: 1.40e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 243 WDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIAD-WVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGI 321
Cdd:cd17378   25 WGLICAGSFLVGLPQSSFFVGCLIGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTGFGRSGI 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 322 ILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALC-RDWQVLQALIICPFLLMLLYWSIFpeslrwlmatqqf 400
Cdd:cd17378  105 GTCALVLATEPVGPKWRGQVGMSTFFFFVLGFMSLPGIAYLNgSSWRVLYFWTSIPALIYCILVYLF------------- 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 401 esAKRLIlhftqknrmnpegdikgvipelekelsrrpkkvcIVKVVGtrnlwknivvlCVNSLTGYGIhhcfarSMMGHE 480
Cdd:cd17378  172 --ARRLL----------------------------------AVMVIG-----------FGIGMVYYGI------PLAVGN 198

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 481 VKVplleNFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGllnligkysqhpdsgMSDSVKDKF 560
Cdd:cd17378  199 LKF----NIYLSVALNALSELPAFVITAFLLDRFGRRPSLLGFTLLSGASCLLCFV---------------LSIGGTTSL 259

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767940491 561 SIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHHIIFA 629
Cdd:cd17378  260 QIALELVGFFGAAGAFNLLYIYTVELFPTCVRNAALGMLRQALVVGGIFAPFIVSLGRKNAALSFGVFG 328
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
 243-388 2.11e-17

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 84.01  E-value: 2.11e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 243 WDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGII 322
Cdd:cd17447   27 WDLVCDRKGLNQATATFFFAGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMFAITRTLTGFALTGFS 106

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767940491 323 LTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFP 388
Cdd:cd17447  107 IISMVLCVEWVDIEHRTVAGVLISLFWTVGNMLLALVAYLIRDWRWLILAVTLPCAPGIITWWWVP 172
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
 243-388 3.21e-15

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 77.51  E-value: 3.21e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 243 WDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGII 322
Cdd:cd17376   27 WNLVCEDDWKVPLTTSLFFVGVLLGSFISGQLSDRFGRKKVLFATMAVQTGFSFLQIFSPSWEMFTVLFVIVGMGQISNY 106

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767940491 323 LTLYALRIELCPPGKRFMITMVASFVAMA-GQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFP 388
Cdd:cd17376  107 VVAFVLGTEILGKSVRILFSTLGVCIFYAiGYMLLPLFAYFIRDWRMLLLALTLPGVLCVPLWWFIP 173
Sugar_tr pfam00083
Sugar (and other) transporter;
259-629 8.75e-15

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 77.31  E-value: 8.75e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491  259 SLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTL---RFFEGFCLAGIILTLYALRIELCPP 335
Cdd:pfam00083  54 IFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVYQLivgRVLVGIGVGGASVLAPMYISEIAPK 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491  336 GKR-FMITMVASFVAMaGQFLMPGLA---ALCRD---WQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLIl 408
Cdd:pfam00083 134 KLRgALGSLYQLAITF-GILLAYIFGlglNKTSNsdgWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVL- 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491  409 hftqKNRMNPEGDIKGVIPELEK-ELSRRPKKVCIVKVVGTRNLWKNIVVLCV----------NSLTGYGihhcfarSMM 477
Cdd:pfam00083 212 ----AKLRGVPDVDRELDEIKDSlEAGQEAEKASWKELFSTKTRRQRLLIGVMlqifqqltgiNAIFYYS-------TTI 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491  478 GHEVKVPllenfyADYYTTASIALVSCLAMCV---VVRFLGRRgGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGmsd 554
Cdd:pfam00083 281 FENLGLS------DSFLVTIIVGVVNFVFTFIaifLVDRFGRR-PLLLLGAAGMAICFVILGIVALLGVSKSDWAGI--- 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491  555 svkdkFSIAFsIVGMFASHAVGSLSVFF--CAEITPTVIRCGGLGLVLAS---AGF--GMLTAPIIELHNQKGYFlhhII 627
Cdd:pfam00083 351 -----VAIVF-IALFIAFFAMGWGPVPWviVSELFPLSVRSKAMALATAAnwlANFliGFLFPIITDAIGLGYTF---FI 421


                  ..
gi 767940491  628 FA 629
Cdd:pfam00083 422 FA 423
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 261-394 1.91e-14

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 75.86  E-value: 1.91e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491  261 LVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKR-- 338
Cdd:TIGR00895  62 LIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRgt 141

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767940491  339 FMITMVASFV--AMAGQFLMPGLAALcRDWQVLQAL-IICPFLLMLLYWSIFPESLRWL 394
Cdd:TIGR00895 142 AVGLMFCGYPigAAVGGFLAGWLIPV-FGWRSLFYVgGIAPLLLLLLLMRFLPESIDFL 199
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 259-405 4.77e-12

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 68.76  E-value: 4.77e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 259 SLL-VGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGK 337
Cdd:cd17358   48 SLLtLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNV 127

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767940491 338 R----FMITMVASFVAMAGQFLmpglaALCRDWQVLqALIIC--PFLLMLLYWSIfPESLRWLMATQQFESAKR 405
Cdd:cd17358  128 RgalgSLNQLLVNIGILLGYVL-----GSFLPWRTL-ALIGAipPVVFLILLFFI-PESPRWLAKKGREEEAEK 194
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 261-387 4.79e-12

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 68.00  E-value: 4.79e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 261 LVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKR-F 339
Cdd:cd17365   44 LFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRsL 123

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767940491 340 MITMVASFV---AMAGQFLMPGLAALCrDWQVL------QALIICPFLL-MLLYWSIF 387
Cdd:cd17365  124 AVTLMFCGYplgAALGGFLAAALIPAF-GWRSVfllggvPPLILLPLLRgTLLLWVTF 180
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 248-588 4.85e-12

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 68.83  E-value: 4.85e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 248 DNAWKVHIAKFslLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALS---VNVTMFSTLRFFEGFClAGIILT 324
Cdd:cd17357   48 DLLWSLIVSIF--FIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSksaKSPELLIFGRFLVGIA-CGLSTG 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 325 LYALRI-ELCPPGKR----FMITMVASFVAMAGQFL-MPGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLMATQ 398
Cdd:cd17357  125 FVPMYLqEISPSELRgalgSLTQIGVTLGILLGQVFgLPSVLGTETLWPYLLFFPGIPALLQLAALPFFPESPKFLLISK 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 399 QFESAKRLILHFTQknrmNPEGDIKGVIPELEKELSR--RPKKVCIVKVVGTRNLWKNIVVLCVNSLTGY--GIHHCFAR 474
Cdd:cd17357  205 GDEEEAEKSLKFLR----GIEDDVDQELEEIKKESEQmgDQKQVSLMQLLRDPSLRLPLLLVLVVSASQQfsGINAIFFY 280

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 475 SM-----MGHEVKVPLLENFYADYYTTASialvSCLAMcVVVRFLGRRGGLLLFMILTAlasllQLGLLNLIGKYSQHPD 549
Cdd:cd17357  281 STfifenAGFSPQLAEWANLGIGIVNVLS----TIVGP-FLIEKVGRRPLLLISLSVCA-----VALLLMSVFLFLSEQN 350

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 767940491 550 SGMSdsvkdKFSIAFSIV-GMFASHAVGSLSVFFCAEITP 588
Cdd:cd17357  351 SWMS-----YGCIVAIFLfIFFFAIGLGPIPWFIGAELFP 385
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 261-408 5.19e-12

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 67.14  E-value: 5.19e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 261 LVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFM 340
Cdd:COG0477   59 LLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGR 138

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767940491 341 ITMVASFVAMAGQFLMPGLAALCRD---WQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLIL 408
Cdd:COG0477  139 ALGLWGAAIGLGLALGPLLGGLLVAalgWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLA 209
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
 233-379 7.19e-12

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 67.47  E-value: 7.19e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 233 DTKRWRPEL--NWDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTL 310
Cdd:cd17375   15 DQSKWESSIvtDWDLVCDREWLAKLIQPIFMLGVLLGAVIFGDIADRIGRRPVLWFTSTGQFVFGIAVAFTFDYYSFVIV 94

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767940491 311 RFFEGFCLAGIILTLYALRIELCPPGKRFMITM-VASFVAmAGQFLMPGLAALCRDW---QVLQALIICPFLL 379
Cdd:cd17375   95 RFLLAMVSSGYLVVVFVYVTEFTGIKARTWASMhVHAFFA-VGIMVVALVGYLVRTWwiyQIILSLVTIPFIL 166
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 259-418 4.20e-11

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 65.14  E-value: 4.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 259 SLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPP--- 335
Cdd:cd06174   39 LFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPErer 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 336 GKRF-MITMVASFVAMAGQFLMPGLA-ALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLILHFTQK 413
Cdd:cd06174  119 GRALgLLQAFGSVGGILGPLLGGILAsSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKR 198


                 ....*
gi 767940491 414 NRMNP 418
Cdd:cd06174  199 VLKNP 203
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
261-392 4.60e-11

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 65.00  E-value: 4.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 261 LVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFM 340
Cdd:COG2814   55 LLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGR 134

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767940491 341 ITMVASFVAMAGQFLMPGLAALCRD---WQVLQALIICPFLLMLLY-WSIFPESLR 392
Cdd:COG2814  135 ALGLLGAGLGLGPALGPLLGGLLADlfgWRWVFLVNAVLALLALLLlLRLLPESRP 190
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 251-523 5.30e-11

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 65.33  E-value: 5.30e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 251 WKVHIAKFSLlvGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTL---RFFEGFClAGIILTLYA 327
Cdd:cd17432   52 WSLTVSIFPL--GGLFGSLLVGPLVIRLGRKGTLLLNNIFAIVAAILMGLSKIAKSFEMIivgRFLVGIN-AGISLNVVP 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 328 LRI-ELCPPGKRFMITMV-ASFVAMA---GQFLmpGLAALC---RDWQVLQALIICPFLLMLLYWSIFPESLRWLMATQQ 399
Cdd:cd17432  129 MYLgESAPKNLRGAVGLVpAIFITLGillGQVL--GLRELLgneEGWPLLLALTGVPALLQLLTLPFFPESPRYLLIEKG 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 400 FESAKRLILHftqknRMNPEGDIKGVIPELEKE----LSRRPKKVCivKVVGTRNL-WKNIVVLCVNSltgyGIHHCFAR 474
Cdd:cd17432  207 DEEAARKALQ-----RLRGKEDVDDEMEEMLEEqraeKGVGTVSVL--ELFRDRSVrWQLISIIVLMA----GQQLCGIN 275

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767940491 475 SMmghevkvplleNFYADY-------------YTTA---SIALVSCLAMCVVVRFLGRRggLLLF 523
Cdd:cd17432  276 AI-----------YFYADSifleagipedkiqYVTVgtgACEVLATITCVLVIERLGRR--PLLI 327
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 261-351 1.07e-10

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 63.77  E-value: 1.07e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 261 LVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKR-F 339
Cdd:cd17316   46 FLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRgF 125

                         90
                 ....*....|..
gi 767940491 340 MITMVASFVAMA 351
Cdd:cd17316  126 ALGLLQSGWALG 137
MFS_1 pfam07690
Major Facilitator Superfamily;
261-389 1.41e-09

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 60.12  E-value: 1.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491  261 LVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKR-F 339
Cdd:pfam07690  42 SLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERgR 121

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767940491  340 MITMVASFVAMaGQFLMPGLAALC---RDWQVLQALIICPFLLMLLYWSIFPE 389
Cdd:pfam07690 122 ALGLVSAGFGL-GAALGPLLGGLLaslFGWRAAFLILAILSLLAAVLLLLPRP 173
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 259-399 1.41e-09

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 60.66  E-value: 1.41e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 259 SLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFC--LAGIILTLYAlrIELCPPG 336
Cdd:cd17359   44 SALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAvgGASALVPMYI--AEVAPAE 121

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767940491 337 KR--------FMIT--MVASFV---AMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYwsIFPESLRWLMATQQ 399
Cdd:cd17359  122 IRgrlvslnqLMIVfgQLLAYIvnyLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGML--FIPESPRWLVSKGK 195
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 259-400 3.37e-09

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 59.12  E-value: 3.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 259 SLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFC--LAGIILTLYalrI-ELCPP 335
Cdd:cd17315   42 SLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGvgLASVLVPLY---IsEIAPA 118

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767940491 336 GKR--------FMITmVASFVAMAGQFLMPGLAALcrDWQVLQALIICPFLLMLLYWSIFPESLRWLMA-----TQQF 400
Cdd:cd17315  119 KIRgalgtlnqLMIT-FGILLAYLLGLALSLSPPG--WWRLMFALAAVPALLQLLLMFFLPESRALLVGvglqlLQQL 193
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 226-467 1.12e-08

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 58.12  E-value: 1.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491  226 GALPWDTDTKRWrPELNWDLVCDNAWKVHIAkfSLLVGLIFGYLITGCIADWVGRRPVLLFSIIFIL---IFGLTVALSV 302
Cdd:TIGR00879  49 GALALPAFEFKF-TSANSDSYSSSLWGLVVS--IFLVGGFIGALFAGWLSDRFGRKKSLLIIALLFVigaILMGLAAFAL 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491  303 NVTMFSTLRFFEGFCLaGIILTLYALRI-ELCPPGKRFMITMVASFVAMAGQFL------MPGLAALCRDWQVLQALIIC 375
Cdd:TIGR00879 126 SVEMLIVGRVLLGIGV-GIASALVPMYLsEIAPKALRGALTSLYQLAITFGILVaygfgsGKVSLNNTLGWRIPLGLQLI 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491  376 PFLLMLLYWSIFPESLRWLMATQQFESAKR-LILHFTQKNRMNPEGDIKGVI-PELEKELSRRPKKVCIVKVVGTRNLWK 453
Cdd:TIGR00879 205 PAGLLFLGLFFLPESPRWLVGKGRVEEARKsLARLRGTSGEDKELLDELELIdIKRSIEKRSVQPSWGSLFSSTRRIRRR 284

                         250       260
                  ....*....|....*....|...
gi 767940491  454 --NIVVLCV-------NSLTGYG 467
Cdd:TIGR00879 285 lfLGVVLQWfqqftgiNAIMYYS 307
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 262-400 4.64e-08

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 55.74  E-value: 4.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 262 VGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFC--LAGIILTLYAlrIELCPPGKRF 339
Cdd:cd17360   46 AGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGvgIASMTVPLYI--AEAAPPRIRG 123

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767940491 340 MITMVASFVAMAGQFLMPGLAA----LCRDWQVLQALIICPFLLMLLYWSIFPESLRW------------LMATQQF 400
Cdd:cd17360  124 RLVTINVLFITGGQFVAYVINGafsyLPGGWRWMLGLAAVPAVLQFIGLLFLPESPRWpstrralivgcgLQAFQQF 200
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 260-389 4.94e-08

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 55.65  E-value: 4.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 260 LLVGLIFGyLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKR- 338
Cdd:cd17474   44 TLPAAVLM-PVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERa 122

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767940491 339 --FMITMVASFVAMAGQFLMPGLAALCrDWQVLQALIICPFLLMLLYWSIFPE 389
Cdd:cd17474  123 kaMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFLLAALIPVAFLAILFLLP 174
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 261-391 1.83e-07

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 53.93  E-value: 1.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491  261 LVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGK--R 338
Cdd:TIGR00710  50 LLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEElsR 129

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491  339 FM-----ITMVASFVA-MAGQFLMPGLAalcrdWQ-VLQALIICPFLLMLLYWSIFPESL 391
Cdd:TIGR00710 130 IYsilmpVLALAPAVApLLGGYILVWLS-----WHaIFAFLSLAGILLSALIFFILPETL 184
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 261-391 2.44e-07

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 53.35  E-value: 2.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 261 LVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKR-- 338
Cdd:cd17320   44 LLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELak 123

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767940491 339 -----FMITMVASFVA-MAGQFLMPGLaalcrDWQ---VLQALIIcpFLLMLLYWSIFPESL 391
Cdd:cd17320  124 ifsllMMILAIAPALApLLGGLLLLFF-----GWRaifVFLALLG--LLLLLLVLLFLPETL 178
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 262-394 3.83e-07

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 53.02  E-value: 3.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 262 VGLIFGYLITGCIADWVGRRPVLLF-SIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKR-- 338
Cdd:cd17356   56 LGSFFGALISSFLSDRIGRKKSIQIgCVIYIIGAIIQVAAIGKWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRgt 135

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767940491 339 ------FMIT---MVASFVAMAGQFLMPGLAalcrdWQVLQALIICPFLLMLLYWSIFPESLRWL 394
Cdd:cd17356  136 lvslyqLAITigiLVAYCINYGTHKLDGSAQ-----WRIPLGLQIVWGLLLLIGMFFLPESPRWL 195
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
261-383 9.89e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 51.41  E-value: 9.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 261 LVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFM 340
Cdd:COG2271   55 FLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGR 134

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 767940491 341 ITMVASFVAMAGQFLMPGLAALC---RDWQVLQALIICPFLLMLLY 383
Cdd:COG2271  135 ALGIFNAGGPLGGALAPPLLGWLlaaFGWRAAFLILGLPGLLLALL 180
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
260-392 1.33e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 51.02  E-value: 1.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 260 LLVGLIFGYLITGCIADWVGRR--PVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGK 337
Cdd:COG2271  225 PFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKA 304

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767940491 338 RFMITMVASFVAMAGQFLMPGLAALCRDWQ----VLQALIICPFLLMLLYWSIFPESLR 392
Cdd:COG2271  305 RGTASGLVNTFGFLGGALGPLLVGYLLDATgyqaAFLLLAALALLAALLALLLLRETRK 363
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 248-398 2.01e-06

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 50.76  E-value: 2.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 248 DNAWKVHIAKFSLLVGLIFGyLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYA 327
Cdd:cd17371   32 DEAEAGLLGTVTLAGGAIGG-ILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAA 110

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767940491 328 LRIELCPPGKR-FMITMVASF------VAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLMATQ 398
Cdd:cd17371  111 LMAEYVPARHRgKALGYVQSGwavgwlLATLLAALLFPLLPPEIAWRVLFLLGALPALLVLFIRRFVKEPPQWQAARA 188
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 243-382 2.70e-06

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 50.16  E-value: 2.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 243 WDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGII 322
Cdd:cd17377   31 WFLVGNAAYKVSLASSFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVMNGGMS 110

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 323 LTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLL 382
Cdd:cd17377  111 LVAFVLLNECVGKSYWALAGSLGGLFFAVGIAQYALLGYFIRSWRTLAVVVNLQGTLVFL 170
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 248-457 7.54e-06

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 48.87  E-value: 7.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 248 DNAWKVHIAKFSllVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTL---RFFEG-FClaGIIL 323
Cdd:cd17431   49 TTLWSLSVAIFS--VGGMIGSFSVGLFVNRFGRRNSMLYNNLLAFAGAALMGLSKLAKSYEMLilgRFIIGlYC--GLTT 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 324 TLYALRI-ELCPPGKRFMI-------TMVASFVAMAgqFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLM 395
Cdd:cd17431  125 GLVPMYIgEISPTALRGALgtlhqlgIVVGILISQI--FGLEFILGTEELWPLLLGFTIVPAILQLALLPFCPESPRYLL 202

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767940491 396 ATQQFESAKRLILhftqkNRMNPEGDIKGVIPELEKELSR--RPKKVCIVKVVGTRNLWKNIVV 457
Cdd:cd17431  203 INRNEEEEAKSVL-----KKLRGTTDVSEDIQEMKEESRQmmREKKVTILELFRSSSYRQPIII 261
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 262-362 9.42e-06

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 48.37  E-value: 9.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 262 VGLIFGYLITGCIADWVGRRPVLLFSIIFILIFG--LTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRF 339
Cdd:cd17316  224 LGALVGALIAGLLSDRIGRKKTLVIGLILSGILAlpLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRA 303

                         90       100
                 ....*....|....*....|...
gi 767940491 340 MITMVASFVAMAGQFLMPGLAAL 362
Cdd:cd17316  304 TGVGLSYNLGRLGGGGAPPLIAL 326
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
258-613 1.27e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 47.95  E-value: 1.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 258 FSLLVGL-----IFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIEL 332
Cdd:COG2223   42 LGLLFAIpvlvgALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKW 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 333 CPPGKRFMIT----MVASFVAMAGQFLMPGLAALcRDWQ-VLQALIICPFLLMLLYWSIFPEslrwlmatqqfesakrli 407
Cdd:COG2223  122 FPPDRRGLALglaaGGGNLGAAVAAFLAPLLIAA-FGWRnAFLILGILLLVVAVLAWLFLRD------------------ 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 408 lhftqknrmnpegdikgvIPELEKELSRRPKKVcIVKVVGTRNLWKNIVVLCVNSLTGYGIHhcfarSMMGhevkvPLLE 487
Cdd:COG2223  183 ------------------PPAGAAAAAKASLRD-QLEALRDPRFWLLSLLYFGTFGSFIGFS-----SWLP-----PYLV 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 488 NFYADYYTTASIALVSCLAMCVVVRFL--------GRRGGLLLFMILTALASLLQLGLLNLIGkysqhpdsgmsdsvkdK 559
Cdd:COG2223  234 DQFGLSAATAGLLAALFALLGALGRPLggwlsdriGGRRVLLIVFALMALGLLLLALALGSLW----------------L 297

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767940491 560 FSIAFSIVGMFAShaVGSLSVF-FCAEITPTVIRCGGLGLVLASAGFGMLTAPII 613
Cdd:COG2223  298 FLVLFLLLGLALG--GGNGAVFaLVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLL 350
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 258-382 1.30e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 47.96  E-value: 1.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 258 FSLLVGLIFGYLitgciADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGK 337
Cdd:cd17325  247 ASALSQPPAGKL-----SDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEG 321

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 767940491 338 RFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLL 382
Cdd:cd17325  322 RGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLL 366
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 260-317 1.34e-05

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 47.96  E-value: 1.34e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767940491 260 LLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFC 317
Cdd:cd17323   43 FVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFF 100
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 258-384 1.94e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 47.42  E-value: 1.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 258 FSLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGK 337
Cdd:cd06174  247 LFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEI 326

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767940491 338 RFMITMVASFVAMAGQFLMPGLAALCRDWQ-----VLQALIICPFLLMLLYW 384
Cdd:cd06174  327 RGTAFGLLNTFGFLGGAIGPLLAGFLLAATfgltgAFLVLAVLLLLAAILLL 378
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
263-356 2.29e-05

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 47.22  E-value: 2.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 263 GLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGK--RFM 340
Cdd:PRK11102  38 GFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAAASVVINALMRDMFPKEEfsRMM 117

                         90       100
                 ....*....|....*....|..
gi 767940491 341 -----ITMVASFVA-MAGQFLM 356
Cdd:PRK11102 118 sfvtlVMTIAPLLApIIGGWLL 139
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 262-352 2.36e-05

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 47.16  E-value: 2.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 262 VGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKR-FM 340
Cdd:cd17324   45 LGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRgRA 124

                         90
                 ....*....|..
gi 767940491 341 ITMVASFVAMAG 352
Cdd:cd17324  125 IGLVFSGLTLGL 136
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 262-390 2.87e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 46.80  E-value: 2.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 262 VGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMI 341
Cdd:cd17325   42 LAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRA 121

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767940491 342 TMVASFVAMAGQFLMPGLAALCRDWQVLQAL-IIC---PFLLMLLYWSIFPES 390
Cdd:cd17325  122 MGIFSSAIGLGFLIGPLLGGLLADALGYRAPfLVCaalALLALVLALLLLPEP 174
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
262-357 3.78e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 46.51  E-value: 3.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 262 VGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRfmi 341
Cdd:COG2814  254 LGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEAR--- 330

                         90
                 ....*....|....*.
gi 767940491 342 TMVASFVAMAGQFLMP 357
Cdd:COG2814  331 GRASGLYNSAFFLGGP 346
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
261-327 4.25e-05

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 46.47  E-value: 4.25e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767940491 261 LVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYA 327
Cdd:PRK15402  58 LAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYA 124
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
261-322 1.10e-04

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 45.27  E-value: 1.10e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767940491 261 LVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFE--GFCLAGII 322
Cdd:PRK11043  51 LAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQavGVCSAAVI 114
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 243-388 1.14e-04

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 45.22  E-value: 1.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 243 WDLvcdNAWKVHIAKFSLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAG-- 320
Cdd:cd17372   29 WNL---SAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVGLGLGGgp 105

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767940491 321 IILTLYAlriELCPPGKRFMITMVASFVAMAGQFLMPGLAALCR---DWQVLQALIICPFLLMLLYWSIFP 388
Cdd:cd17372  106 QLASWYL---EFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMprlGWRWLLAFSSVPSSLLLVFYRWTP 173
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 236-399 1.68e-04

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 44.57  E-value: 1.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 236 RWRPELNWDlVCDNAWKVHIAKFSLLVGLIFGylitGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEG 315
Cdd:PRK11551  40 RMAQEFGLD-VAQMGWAFSAGILGLLPGALLG----GRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTG 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 316 FCLAGIILTLYALRIELCPPGKR-----FMIT------MVASFVAMagqflmpgLAALCRDWQV------LQALIICPFL 378
Cdd:PRK11551 115 VGLGGALPNLIALTSEAVGPRLRgtavsLMYCgvpfggALASVIGV--------LAAGDAAWRHifyvggVGPLLLVPLL 186

                        170       180
                 ....*....|....*....|.
gi 767940491 379 LMLLywsifPESLRWLMATQQ 399
Cdd:PRK11551 187 MRWL-----PESRAFAQAAGA 202
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
 262-468 3.08e-04

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 43.75  E-value: 3.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 262 VGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKR--- 338
Cdd:cd17440   45 LGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGYGLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREKRgeh 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 339 ----FMITMVASFVAMA---------GQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAkR 405
Cdd:cd17440  125 lswlCMFWMIGGIYASAmawaiiphyGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEA-W 203

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767940491 406 LILHFTQKNRMNPEGdikgvipelekelsrRPKKVCIVKVVGTRNLWKNIVVLCVNSLTGYGI 468
Cdd:cd17440  204 MILKQIHDTNMRARG---------------QPEKVFTVNRIKKDNTIKLTIVWLTLSFGYYGL 251
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 259-396 3.75e-04

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 43.25  E-value: 3.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 259 SLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEG--FCLAGIILTLYAlrIELCPPG 336
Cdd:cd17435   44 SLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCSVSYTVLIVGRIAIGvsISLSSIATCVYI--AEIAPQH 121

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767940491 337 KRFMITMVASFVAMAGQFLMPGL----AALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLMA 396
Cdd:cd17435  122 RRGLLVSLNELMIVIGILLAYISnyafANVSNGWKYMFGLVIPLAALQAIAMYFLPPSPRFLVM 185
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 269-382 5.32e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 42.97  E-value: 5.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 269 LITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKR----FMITMv 344
Cdd:cd17489   49 PFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRgegiGYYGL- 127

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767940491 345 ASFVAMAgqfLMPGLAALCRDWQVLQALIICPFLLMLL 382
Cdd:cd17489  128 ATTLAMA---LGPALGLFLYQHLGFAVLFIVAAVLALL 162
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 258-338 7.81e-04

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 42.26  E-value: 7.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 258 FSLLVGLIFGYL------ITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFClAGIILTLYALRIE 331
Cdd:cd17389   65 FGGLIGSLFSLLqflsspITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGIS-KGNVSLSTAIVAD 143


                 ....*..
gi 767940491 332 LCPPGKR 338
Cdd:cd17389  144 VTSPKKR 150
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 261-322 8.14e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 42.18  E-value: 8.14e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767940491 261 LVGLIFGYLItGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGII 322
Cdd:cd17330   45 LGQFLASPLW-GRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVS 105
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
254-315 9.04e-04

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 42.32  E-value: 9.04e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767940491 254 HIAkFSL-LVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEG 315
Cdd:PRK10473  41 HIA-FSVyLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQG 102
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 270-359 1.31e-03

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 41.79  E-value: 1.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 270 ITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVA 349
Cdd:cd17503   50 LSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVI 129

                         90
                 ....*....|
gi 767940491 350 MAGQFLMPGL 359
Cdd:cd17503  130 LLAPAIGPTL 139
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
261-383 1.37e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 41.76  E-value: 1.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 261 LVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFM 340
Cdd:COG0738  256 WGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAA 335

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 767940491 341 ITMVASFvAMAGQFLMPGLAALCRDWQVLQA---LIICPFLLMLLY 383
Cdd:COG0738  336 VSAVLIM-GIVGGAIGPPLIGFLADAFGLRAaflVPLVCYLLILLL 380
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 258-385 1.64e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 41.39  E-value: 1.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 258 FSLLVGLIFGYLItGCIADWVGRRPVLLFSIIFILIFGLTVALsvnVTMFSTLRFFEGFCLAGIILTLYALRIELCppGK 337
Cdd:cd17477  231 AFVLGGLLLQWPL-GWLADRFDRRRVLLGCALLGALAALLLPL---VPGLPLALLVLLFLWGGAAGPLYTLALALA--GD 304

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767940491 338 RF----MITMVASFVAM--AGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWS 385
Cdd:cd17477  305 RLpgdeLVAANAALLLLygLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLL 358
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 259-393 1.90e-03

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 41.18  E-value: 1.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 259 SLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTV--ALSVNVTMFSTLRFFEGFCLAGIILTLYAlrIELCPPG 336
Cdd:cd17362   47 GSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTglAPSYPVLLVGRLIYGVGIGLAMHAAPVYI--AETSPSH 124

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767940491 337 KR-FMITMVASFVA---MAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLRW 393
Cdd:cd17362  125 IRgLLVSLKELFIVlgiLLGYVSGYAFADVVGGWRYMYGLAAPPALLLGIGMWFLPPSPRW 185
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 258-338 2.76e-03

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 40.75  E-value: 2.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 258 FSLLVGLIFGYLITGCIADWVGRRP-VLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPG 336
Cdd:cd17371  252 VVTILGGFLGYLAGGFLADRIGRRNnFALFALGSAISILLYFFLPLSPTLILILGFPLGFFASGPFSGMGAYLTELFPTA 331


                 ..
gi 767940491 337 KR 338
Cdd:cd17371  332 VR 333
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
258-388 3.03e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 40.61  E-value: 3.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 258 FSLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGK 337
Cdd:COG0738   50 FAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETA 129

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767940491 338 RFMITMVASFVAMAGqFLMPGLAALC------RDWQVLQALIICPFLLMLLYWSIFP 388
Cdd:COG0738  130 ASRLNLLHAFFSLGA-LLGPLLGGLLillglsLSWHLPYLILAVLLLLLALLFLRSK 185
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
 250-394 3.13e-03

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 40.57  E-value: 3.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 250 AWKVHIAKFSLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGI--ILTLYA 327
Cdd:cd17441   33 SWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWILVLRGLVGFGIGGVpqSVTLYA 112

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767940491 328 lriELCPPGKRFM-ITMVASFVAMAGQF-------LMPGLAalcrdWQVLQALIICPFLL--MLLYWsiFPESLRWL 394
Cdd:cd17441  113 ---EFLPMKSRAKcILLIEVFWALGTVFevllavfVMPTLG-----WRWLLILSALPLLIfaVLCFW--LPESARYW 179
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 255-394 5.70e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 39.48  E-value: 5.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 255 IAKFSLLVGLIfgylitgciADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGII---LTLYALRIE 331
Cdd:cd17473   48 IALFAPLAGWL---------ADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMtlaTALIGDYFE 118

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767940491 332 lcppGK---RFM--ITMVASFVAMAGQFLMPGLAALcrDWQVlqaliicPFLLMLLYWSIFPESLRWL 394
Cdd:cd17473  119 ----GEeraKMLglQSAAMSLGGVVFLLLGGALAEI--GWRA-------PFLVYLLALPVLILVLLFL 173
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 262-384 5.90e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 39.50  E-value: 5.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 262 VGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMi 341
Cdd:cd17489  238 IALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGA- 316

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 767940491 342 TMVASFVAM-----AGQFLMPGLAALCRDWQVLQALIICPFLLMLLYW 384
Cdd:cd17489  317 ANGTFFIFFdlgigLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYI 364
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 258-400 8.43e-03

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 39.09  E-value: 8.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940491 258 FSLLVGLIF-GYLIT----GCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRF----FEGFCLAGIILTLYal 328
Cdd:cd17319   40 YGLIASAFFlGYALFqvpgGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFllgvAEAGFFPGAIKALA-- 117

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767940491 329 riELCPPGKR---FMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLrWLMATQQF 400
Cdd:cd17319  118 --EWFPARERgraTGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQV-WGLALGYF 189
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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