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Conserved domains on  [gi|767949001|ref|XP_011514978|]
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plexin-A4 isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sema_plexin_A4 cd11274
The Sema domain, a protein interacting module, of Plexin A4; Plexin A4 forms a receptor ...
 39-511 0e+00

The Sema domain, a protein interacting module, of Plexin A4; Plexin A4 forms a receptor complex with neuropilins (NRPs) and transduces signals for class 3 semaphorins in the nervous system. It regulates facial nerve development by functioning as a receptor for Sema3A/NRP1. Both plexins A3 and A4 are essential for normal sympathetic development. They function both cooperatively, to regulate the migration of sympathetic neurons, and differentially, to guide sympathetic axons. Plexin A4 is also expressed in lymphoid tissues and functions in the immune system. It negatively regulates T lymphocyte responses. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


:

Pssm-ID: 200535 [Multi-domain]  Cd Length: 473  Bit Score: 1051.85  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001   39 SFVTFRGEPAEGFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPLTTTNNVNKML 118
Cdd:cd11274     1 FITFTGDQTEWTFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHQTGPDEDNPKCYPPRIVQTCNEPLTLTNNINKML 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  119 LIDYKENRLIACGSLYQGICKLLRLEDLFKLGEPYHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYFPT 198
Cdd:cd11274    81 LIDYKENRLIACGSLYQGICKLLRLDDLFKLGEPFHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYFPT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  199 ISSRKLTKNSEADGMFAYVFHDEFVASMIKIPSDTFTIIPDFDIYYVYGFSSGNFVYFLTLQPEMVSPPGSTTKEQVYTS 278
Cdd:cd11274   161 ISSRKLTKNSEADGMFAYVFHDEFVASMIKIPSDTFTIIPDFDIYYIYGFSSGNFVYFLTLQPEMISPPGSTTKEQVYTS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  279 KLVRLCKEDTAFNSYVEVPIGCERSGVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQKRKMKSLDESALCIF 358
Cdd:cd11274   241 KLVRLCKEDTAFNSYVEVPIGCEKNGVEYRLLQAAYLSKAGAILARSLGVGPDDDILFTVFSKGQKRKMKSLDESALCIF 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  359 ILKQINDRIKERLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDDNFCGLDMNAPLGVSDMVRGIPVFTEDRDRMTSVIAY 438
Cdd:cd11274   321 VLKEINDRIKDRLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDDNFCGLDMNAPLGVSEMVRGLPVFTEDRDRMTSVIAY 400

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767949001  439 VYKNHSLAFVGTKSGKLKKIRVDGPRGNALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVPVESCG 511
Cdd:cd11274   401 VYKNHSLAFVGTKSGKLKKIRVDGTTKNALQYETVQVVDTGPILRDMAFSKDHEQLYIMSEKQLTRVPVESCG 473
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1040-1140 8.35e-47

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238586  Cd Length: 99  Bit Score: 162.59  E-value: 8.35e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001 1040 PTIVRIEPEWSIVSGNTPIAVWGTHLDLIQNPQIRAKHGGKEHINiCEVLNATEMTCQAPALALGPDHQsDLTERPEEFG 1119
Cdd:cd01181     1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRVKYGGVEKTS-CKVRNSTLMTCPAPSLALLNRSP-EPGERPVEFG 78

                          90       100
                  ....*....|....*....|.
gi 767949001 1120 FILDNVQSLLILNKTNFTYYP 1140
Cdd:cd01181    79 LDGDNVQSLLILNRTSFSYYP 99
TIG_2 pfam18020
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG ...
 708-802 1.25e-39

TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG domains have an Ig-like fold.


:

Pssm-ID: 465619  Cd Length: 94  Bit Score: 142.03  E-value: 1.25e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001   708 DKILVPVEVIKPITLKAKNLPQPQSGQRGYECILNIQGSEQRVPALRFNSSSVQCQNTSYSYEGMeINNLPVELTVVWNG 787
Cdd:pfam18020    1 GSILVPVGVEREITLKARNLPLFQSGQLGYECVFEIEGATHVVPASRESSDSITCQEHQFSYSGS-SGELPATFYVTWNG 79

                           90
                   ....*....|....*
gi 767949001   788 HFNIDNPAQNKVHLY 802
Cdd:pfam18020   80 GHRLDNPANLQVVLY 94
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 955-1038 1.97e-34

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238584  Cd Length: 85  Bit Score: 126.96  E-value: 1.97e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  955 TLSDLKPSRGPMSGGTQVTITGTNLNAGSNVVVMFGKQPCLFHRRSPSYIVCNTTSSDEVLEMKVSVQVDRAKIHQDLVF 1034
Cdd:cd01179     2 SITSLSPSYGPQSGGTRLTITGKHLNAGSSVRVTVGGQPCKILSVSSSQIVCLTPPSASPGEAPVKVLIDGARRLAPLVF 81


                  ....
gi 767949001 1035 QYVE 1038
Cdd:cd01179    82 TYTE 85
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 858-953 1.22e-26

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238585  Cd Length: 94  Bit Score: 105.09  E-value: 1.22e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  858 PRITEIIPVTGPREGGTKVTIRGENLGLEFRDIASHVKVAGVECSPLVDGYIPAEQIVCEMGEAKPSQHAGFVEICVAVC 937
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRHGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNPVFNGPVEVTVGHG 80

                          90
                  ....*....|....*.
gi 767949001  938 rpEFMARSSQLYYFMT 953
Cdd:cd01180    81 --SFRTESSEGFSFVD 94
TIG_plexin pfam17960
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and ...
 564-654 5.84e-24

TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and Transcription factors) found in plexins.


:

Pssm-ID: 465588  Cd Length: 89  Bit Score: 96.95  E-value: 5.84e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001   564 HPNNISVSQY-NVLLVLEtyNVPELSAGVNCTFEDLSEMDGLVVGNQIQCYSPAAKEVPRIiTENGDHHVVQLQLKSKET 642
Cdd:pfam17960    1 TPDNISRTTAtQLTLTVP--NLPALSEGYSCVFGDLTESPATVHDNGVKCATPPPSQLPPI-PTGQDHVTVKLSLRSSET 77

                           90
                   ....*....|..
gi 767949001   643 GMTFASTSFVFY 654
Cdd:pfam17960   78 GVDFASTNFTFY 89
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
510-548 1.06e-13

domain found in Plexins, Semaphorins and Integrins;


:

Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 66.41  E-value: 1.06e-13
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 767949001    510 CGQYQSCGECLGSGDPHCGWCVLHNTCTRKERCERSKEP 548
Cdd:smart00423    2 CSKYTSCSECLLARDPYCAWCSSQGRCTSGERCDSRRQN 40
RasGAP super family cl02569
Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is ...
 1311-1339 1.68e-11

Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin, among others. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP exhibit no similarity at their amino acid sequence level. RasGTPases function as molecular switches in a large number of signaling pathways. They are in the on state when bound to GTP, and in the off state when bound to GDP. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


The actual alignment was detected with superfamily member cd12790:

Pssm-ID: 470620 [Multi-domain]  Cd Length: 385  Bit Score: 67.83  E-value: 1.68e-11
                          10        20
                  ....*....|....*....|....*....
gi 767949001 1311 GIPFLDYRTYTMRVLFPGIEDHPVLRDLE 1339
Cdd:cd12790     1 GIPFLDYRTYAMRVLFPGIEDHPVLRELE 29
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 804-856 2.98e-08

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


:

Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 51.17  E-value: 2.98e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767949001   804 CGAMReSCGLCLKADpDFACGWCQGPGQCTLRQHCPAQESQWLELSGAKSKCT 856
Cdd:pfam01437    2 CSQYT-SCSSCLAAR-DPYCGWCSSEGRCVRRSACGAPEGNCEEWEQASSKCP 52
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 655-702 1.04e-07

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


:

Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 49.63  E-value: 1.04e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767949001   655 NCSVHNSCLSCVESP-YRCHWCKYRHVCTHdPKTCSFQEGR----VKLPEDCP 702
Cdd:pfam01437    1 RCSQYTSCSSCLAARdPYCGWCSSEGRCVR-RSACGAPEGNceewEQASSKCP 52
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1142-1222 1.17e-06

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 47.83  E-value: 1.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001 1142 PVFEAFGPS-GILElkPGTPIILKGKNLippvagGNVKLNYTVLVGEKPCTVT-VSDVQLLCESP--NLIGRHKVMARVG 1217
Cdd:cd00603     1 PVITSISPSsGPLS--GGTRLTITGSNL------GSGSPRVRVTVGGVPCKVLnVSSTEIVCRTPaaATPGEGPVEVTVD 72


                  ....*
gi 767949001 1218 GMEYS 1222
Cdd:cd00603    73 GANVS 77
 
Name Accession Description Interval E-value
Sema_plexin_A4 cd11274
The Sema domain, a protein interacting module, of Plexin A4; Plexin A4 forms a receptor ...
 39-511 0e+00

The Sema domain, a protein interacting module, of Plexin A4; Plexin A4 forms a receptor complex with neuropilins (NRPs) and transduces signals for class 3 semaphorins in the nervous system. It regulates facial nerve development by functioning as a receptor for Sema3A/NRP1. Both plexins A3 and A4 are essential for normal sympathetic development. They function both cooperatively, to regulate the migration of sympathetic neurons, and differentially, to guide sympathetic axons. Plexin A4 is also expressed in lymphoid tissues and functions in the immune system. It negatively regulates T lymphocyte responses. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200535 [Multi-domain]  Cd Length: 473  Bit Score: 1051.85  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001   39 SFVTFRGEPAEGFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPLTTTNNVNKML 118
Cdd:cd11274     1 FITFTGDQTEWTFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHQTGPDEDNPKCYPPRIVQTCNEPLTLTNNINKML 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  119 LIDYKENRLIACGSLYQGICKLLRLEDLFKLGEPYHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYFPT 198
Cdd:cd11274    81 LIDYKENRLIACGSLYQGICKLLRLDDLFKLGEPFHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYFPT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  199 ISSRKLTKNSEADGMFAYVFHDEFVASMIKIPSDTFTIIPDFDIYYVYGFSSGNFVYFLTLQPEMVSPPGSTTKEQVYTS 278
Cdd:cd11274   161 ISSRKLTKNSEADGMFAYVFHDEFVASMIKIPSDTFTIIPDFDIYYIYGFSSGNFVYFLTLQPEMISPPGSTTKEQVYTS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  279 KLVRLCKEDTAFNSYVEVPIGCERSGVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQKRKMKSLDESALCIF 358
Cdd:cd11274   241 KLVRLCKEDTAFNSYVEVPIGCEKNGVEYRLLQAAYLSKAGAILARSLGVGPDDDILFTVFSKGQKRKMKSLDESALCIF 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  359 ILKQINDRIKERLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDDNFCGLDMNAPLGVSDMVRGIPVFTEDRDRMTSVIAY 438
Cdd:cd11274   321 VLKEINDRIKDRLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDDNFCGLDMNAPLGVSEMVRGLPVFTEDRDRMTSVIAY 400

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767949001  439 VYKNHSLAFVGTKSGKLKKIRVDGPRGNALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVPVESCG 511
Cdd:cd11274   401 VYKNHSLAFVGTKSGKLKKIRVDGTTKNALQYETVQVVDTGPILRDMAFSKDHEQLYIMSEKQLTRVPVESCG 473
Sema smart00630
semaphorin domain;
51-482 1.81e-75

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 256.53  E-value: 1.81e-75
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001     51 FNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRivqtCNEPLTTTNNVNK-MLLIDYKENRLIA 129
Cdd:smart00630    1 LQHLLLDEDNGTLYVGARNRLYQLSLNLILEAELKTGPVLSSPDCEECV----SKGKDPPTDCVNYiRLLLDYNEDRLLV 76

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001    130 CGS-LYQGICKLLRLEDLFklgepyhkkehylsgvnesgsvfgvivsysnlddklfIATAVD--GKPEYFPTISSRKLTK 206
Cdd:smart00630   77 CGTnAFQPVCRLRNLGELY-------------------------------------VGTVADfsGSDPAIPRSLSVRRLK 119

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001    207 NSeadgmfaYVFHDEFVASMIKIPSDtftiipdfdIYYVYGFSSGNFVYFLTLQPEMVsppgSTTKEQVYTSKLVRLCKE 286
Cdd:smart00630  120 GT-------SGVSLRTVLYDSKWLNE---------PNFVYAFESGDFVYFFFRETAVE----DDNCGKAVHSRVARVCKN 179

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001    287 DTA--------FNSYVEVPIGC---ERSGVEYRLLQAAYLSKAGAvlgrtlgvhPDDDLLFTVFSKGQkrkmKSLDESAL 355
Cdd:smart00630  180 DVGgprsldkkWTSFLKARLECsvpGEDPFYFNELQAAFLLPPGS---------ESDDVLYGVFSTSS----NPIPGSAV 246

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001    356 CIFILKQINDRIKERLQSCYRGEGTLDL----AWLKVKDIPC-----SSALLTIDDNFCGLDMNAPLGVSDMVRGIPVFT 426
Cdd:smart00630  247 CAFSLSDINAVFNGPFKECETSTSQWLPysrgKVPYPRPGTCpnkppSSKDLPDETLNFIKSHPLMDEVVQPLTGRPLFV 326

                           410       420       430       440       450       460
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767949001    427 E--DRDRMTSVIAYV---YKNHSLAFVGTKSGKLKKIRVDGPRGN--ALQYETVQVVDPG-PVL 482
Cdd:smart00630  327 KtdSNYLLTSIAVDRvatDGNYTVLFLGTSDGRILKVVLSESSSSseSVVLEEISVFPDGsPIS 390
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1040-1140 8.35e-47

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238586  Cd Length: 99  Bit Score: 162.59  E-value: 8.35e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001 1040 PTIVRIEPEWSIVSGNTPIAVWGTHLDLIQNPQIRAKHGGKEHINiCEVLNATEMTCQAPALALGPDHQsDLTERPEEFG 1119
Cdd:cd01181     1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRVKYGGVEKTS-CKVRNSTLMTCPAPSLALLNRSP-EPGERPVEFG 78

                          90       100
                  ....*....|....*....|.
gi 767949001 1120 FILDNVQSLLILNKTNFTYYP 1140
Cdd:cd01181    79 LDGDNVQSLLILNRTSFSYYP 99
TIG_2 pfam18020
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG ...
 708-802 1.25e-39

TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG domains have an Ig-like fold.


Pssm-ID: 465619  Cd Length: 94  Bit Score: 142.03  E-value: 1.25e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001   708 DKILVPVEVIKPITLKAKNLPQPQSGQRGYECILNIQGSEQRVPALRFNSSSVQCQNTSYSYEGMeINNLPVELTVVWNG 787
Cdd:pfam18020    1 GSILVPVGVEREITLKARNLPLFQSGQLGYECVFEIEGATHVVPASRESSDSITCQEHQFSYSGS-SGELPATFYVTWNG 79

                           90
                   ....*....|....*
gi 767949001   788 HFNIDNPAQNKVHLY 802
Cdd:pfam18020   80 GHRLDNPANLQVVLY 94
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 955-1038 1.97e-34

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 126.96  E-value: 1.97e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  955 TLSDLKPSRGPMSGGTQVTITGTNLNAGSNVVVMFGKQPCLFHRRSPSYIVCNTTSSDEVLEMKVSVQVDRAKIHQDLVF 1034
Cdd:cd01179     2 SITSLSPSYGPQSGGTRLTITGKHLNAGSSVRVTVGGQPCKILSVSSSQIVCLTPPSASPGEAPVKVLIDGARRLAPLVF 81


                  ....
gi 767949001 1035 QYVE 1038
Cdd:cd01179    82 TYTE 85
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
 310-488 4.39e-31

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 120.84  E-value: 4.39e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001   310 LQAAYLSKAGAVLGRtlgvhpdDDLLFTVFSKGQKrkmKSLDESALCIFILKQINDRIKERlqscYRGEGTLDLAWLKV- 388
Cdd:pfam01403    1 LQDVFVLKPGAGDAL-------DTVLYGVFTTQWS---NSIGGSAVCAFSLSDINAVFEGP----FKEQEKSDSKWLPYt 66

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001   389 ------KDIPC--SSALLTIDDNFCGLDMNAPLGVS--DMVRGIPVFTEDRDRMTSVIAY----VYKNHSLAFVGTKSGK 454
Cdd:pfam01403   67 gkvpypRPGTCinDPLRLDLPDSVLNFVKDHPLMDEavQPVGGRPLLVRTGVRLTSIAVDrvqaLDGNYTVLFLGTDDGR 146

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 767949001   455 LKKIrVDGPRGNALQYETVQVVDPG-PVLRDMAFS 488
Cdd:pfam01403  147 LHKV-VLVGSEESHIIEEIQVFPEPqPVLNLLLSS 180
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 858-953 1.22e-26

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 105.09  E-value: 1.22e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  858 PRITEIIPVTGPREGGTKVTIRGENLGLEFRDIASHVKVAGVECSPLVDGYIPAEQIVCEMGEAKPSQHAGFVEICVAVC 937
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRHGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNPVFNGPVEVTVGHG 80

                          90
                  ....*....|....*.
gi 767949001  938 rpEFMARSSQLYYFMT 953
Cdd:cd01180    81 --SFRTESSEGFSFVD 94
TIG_plexin pfam17960
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and ...
 564-654 5.84e-24

TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and Transcription factors) found in plexins.


Pssm-ID: 465588  Cd Length: 89  Bit Score: 96.95  E-value: 5.84e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001   564 HPNNISVSQY-NVLLVLEtyNVPELSAGVNCTFEDLSEMDGLVVGNQIQCYSPAAKEVPRIiTENGDHHVVQLQLKSKET 642
Cdd:pfam17960    1 TPDNISRTTAtQLTLTVP--NLPALSEGYSCVFGDLTESPATVHDNGVKCATPPPSQLPPI-PTGQDHVTVKLSLRSSET 77

                           90
                   ....*....|..
gi 767949001   643 GMTFASTSFVFY 654
Cdd:pfam17960   78 GVDFASTNFTFY 89
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
510-548 1.06e-13

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 66.41  E-value: 1.06e-13
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 767949001    510 CGQYQSCGECLGSGDPHCGWCVLHNTCTRKERCERSKEP 548
Cdd:smart00423    2 CSKYTSCSECLLARDPYCAWCSSQGRCTSGERCDSRRQN 40
IPT smart00429
ig-like, plexins, transcription factors;
1039-1139 2.00e-13

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 67.06  E-value: 2.00e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001   1039 DPTIVRIEPEWSIVSGNTPIAVWGTHLDLIQNPQIRAKHGGKEhiniCEVLN--ATEMTCQAPalalgPDHQSDLTERPE 1116
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEAP----CTFSPssSTAIVCKTP-----PYHNIPGSVPVR 71

                            90       100
                    ....*....|....*....|...
gi 767949001   1117 EFGFILDNVQSLlilnKTNFTYY 1139
Cdd:smart00429   72 TVGLRNGGVPSS----PQPFTYV 90
IPT smart00429
ig-like, plexins, transcription factors;
857-950 3.84e-13

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 66.29  E-value: 3.84e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001    857 NPRITEIIPVTGPREGGTKVTIRGENLGlEFRDIASHVKVAGVECSPLVDGyipAEQIVCEMGEAKPSQHAGFVEiCVAV 936
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLK-SISVVFVEVGVGEAPCTFSPSS---STAIVCKTPPYHNIPGSVPVR-TVGL 75

                            90
                    ....*....|....
gi 767949001    937 CRPEFMARSSQLYY 950
Cdd:smart00429   76 RNGGVPSSPQPFTY 89
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 509-551 5.37e-13

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 64.65  E-value: 5.37e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 767949001   509 SCGQYQSCGECLGSGDPHCGWCVLHNTCTRKERCERSKEPRRF 551
Cdd:pfam01437    1 RCSQYTSCSSCLAARDPYCGWCSSEGRCVRRSACGAPEGNCEE 43
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 954-1036 1.27e-12

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 64.78  E-value: 1.27e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001   954 LTLSDLKPSRGPMSGGTQVTITGTNLNAGS-NVVVMFGKQPCLFHRRSPSYIVCNTTSSDEVLeMKVSVQV-DRAKIHQD 1031
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSsDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGL-VNVSVTVgGGGISSSP 79


                   ....*
gi 767949001  1032 LVFQY 1036
Cdd:pfam01833   80 LTFTY 84
IPT smart00429
ig-like, plexins, transcription factors;
954-1037 1.49e-11

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 62.05  E-value: 1.49e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001    954 LTLSDLKPSRGPMSGGTQVTITGTNLNAGSNVVVMF--GKQPCLFHRRSPSYIVCNTTS-SDEVLEMKVS-VQVDRAKIH 1029
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVgvGEAPCTFSPSSSTAIVCKTPPyHNIPGSVPVRtVGLRNGGVP 81


                    ....*....
gi 767949001   1030 -QDLVFQYV 1037
Cdd:smart00429   82 sSPQPFTYV 90
RasGAP_plexin_A cd12790
Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of ...
 1311-1339 1.68e-11

Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. They are divided into four types (A-D) according to sequence similarity. In vertebrates, there are four type A plexins (A1-A4) that serve as the co-receptors for neuropilins to mediate the signaling of class 3 semaphorins except Sema3E, which signals through Plexin-D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 1 and class 6 semaphorins signal through type A plexins, which mediate diverse biological functions including axon guidance, cardiovascular development, and immune function. Guanylyl cyclase Gyc76C and Off-track kinase (OTK), a putative receptor tyrosine kinase, modulate Sema1a and Plexin-A mediated axon repulsion. In their complex with Sema6s, type A plexins serve as signal-transducing subunits. An increasing number of molecules that interact with the intracellular region of Plexin-A have been identified; among them are IgCAMs (in axon guidance events) and Trem2-DAP12 (in immune responses). Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213350 [Multi-domain]  Cd Length: 385  Bit Score: 67.83  E-value: 1.68e-11
                          10        20
                  ....*....|....*....|....*....
gi 767949001 1311 GIPFLDYRTYTMRVLFPGIEDHPVLRDLE 1339
Cdd:cd12790     1 GIPFLDYRTYAMRVLFPGIEDHPVLRELE 29
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 858-937 8.13e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 59.77  E-value: 8.13e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001   858 PRITEIIPVTGPREGGTKVTIRGENLGLEFRDIasHVKVAGVECSPLvdgYIPAEQIVCEMgeakPSQHAGFVEICVAVC 937
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDL--KVTIGGTPCTVI---SVSSTTIVCTT----PPGTSGLVNVSVTVG 71
Plexin_cytopl pfam08337
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ...
 1311-1343 2.61e-09

Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.


Pssm-ID: 462434 [Multi-domain]  Cd Length: 500  Bit Score: 61.44  E-value: 2.61e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 767949001  1311 GIPFLDYRTYTMRVLFPGIEDHPVLRDLEASVL 1343
Cdd:pfam08337    1 GIPFLDYRTYAMRVLFPGVEDHPLLVLLDVPVT 33
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 804-856 2.98e-08

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 51.17  E-value: 2.98e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767949001   804 CGAMReSCGLCLKADpDFACGWCQGPGQCTLRQHCPAQESQWLELSGAKSKCT 856
Cdd:pfam01437    2 CSQYT-SCSSCLAAR-DPYCGWCSSEGRCVRRSACGAPEGNCEEWEQASSKCP 52
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 655-702 1.04e-07

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 49.63  E-value: 1.04e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767949001   655 NCSVHNSCLSCVESP-YRCHWCKYRHVCTHdPKTCSFQEGR----VKLPEDCP 702
Cdd:pfam01437    1 RCSQYTSCSSCLAARdPYCGWCSSEGRCVR-RSACGAPEGNceewEQASSKCP 52
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
655-702 1.14e-06

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 46.77  E-value: 1.14e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 767949001    655 NCSVHNSCLSCVESPY-RCHWCKYRHVCTHDPkTCSFQEGRVkLPEDCP 702
Cdd:smart00423    1 RCSKYTSCSECLLARDpYCAWCSSQGRCTSGE-RCDSRRQNW-LSGGCP 47
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1142-1222 1.17e-06

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 47.83  E-value: 1.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001 1142 PVFEAFGPS-GILElkPGTPIILKGKNLippvagGNVKLNYTVLVGEKPCTVT-VSDVQLLCESP--NLIGRHKVMARVG 1217
Cdd:cd00603     1 PVITSISPSsGPLS--GGTRLTITGSNL------GSGSPRVRVTVGGVPCKVLnVSSTEIVCRTPaaATPGEGPVEVTVD 72


                  ....*
gi 767949001 1218 GMEYS 1222
Cdd:cd00603    73 GANVS 77
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
806-849 1.77e-06

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 46.00  E-value: 1.77e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 767949001    806 AMRESCGLCLKAdPDFACGWCQGPGQCTLRQHCPAQESQWLELS 849
Cdd:smart00423    3 SKYTSCSECLLA-RDPYCAWCSSQGRCTSGERCDSRRQNWLSGG 45
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1142-1226 2.22e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 43.97  E-value: 2.22e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  1142 PVFEAFGPSGIlELKPGTPIILKGKNLippvagGNVKLNYTVLVGEKPCTV-TVSDVQLLCESPNL-IGRHKVMARVGGM 1219
Cdd:pfam01833    1 PVITSISPSSG-PASGGTTITITGSNF------GTDSSDLKVTIGGTPCTViSVSSTTIVCTTPPGtSGLVNVSVTVGGG 73


                   ....*..
gi 767949001  1220 EYSPGMV 1226
Cdd:pfam01833   74 GISSSPL 80
IPT smart00429
ig-like, plexins, transcription factors;
1141-1204 3.37e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 40.87  E-value: 3.37e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767949001   1141 NPVFEAFGP-SGILElkPGTPIILKGKNLIPpvaGGNVKlnYTVLVGEKPCTVT-VSDVQLLCESP 1204
Cdd:smart00429    1 DPVITRISPtSGPVS--GGTEITLCGKNLKS---ISVVF--VEVGVGEAPCTFSpSSSTAIVCKTP 59
 
Name Accession Description Interval E-value
Sema_plexin_A4 cd11274
The Sema domain, a protein interacting module, of Plexin A4; Plexin A4 forms a receptor ...
 39-511 0e+00

The Sema domain, a protein interacting module, of Plexin A4; Plexin A4 forms a receptor complex with neuropilins (NRPs) and transduces signals for class 3 semaphorins in the nervous system. It regulates facial nerve development by functioning as a receptor for Sema3A/NRP1. Both plexins A3 and A4 are essential for normal sympathetic development. They function both cooperatively, to regulate the migration of sympathetic neurons, and differentially, to guide sympathetic axons. Plexin A4 is also expressed in lymphoid tissues and functions in the immune system. It negatively regulates T lymphocyte responses. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200535 [Multi-domain]  Cd Length: 473  Bit Score: 1051.85  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001   39 SFVTFRGEPAEGFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPLTTTNNVNKML 118
Cdd:cd11274     1 FITFTGDQTEWTFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHQTGPDEDNPKCYPPRIVQTCNEPLTLTNNINKML 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  119 LIDYKENRLIACGSLYQGICKLLRLEDLFKLGEPYHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYFPT 198
Cdd:cd11274    81 LIDYKENRLIACGSLYQGICKLLRLDDLFKLGEPFHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYFPT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  199 ISSRKLTKNSEADGMFAYVFHDEFVASMIKIPSDTFTIIPDFDIYYVYGFSSGNFVYFLTLQPEMVSPPGSTTKEQVYTS 278
Cdd:cd11274   161 ISSRKLTKNSEADGMFAYVFHDEFVASMIKIPSDTFTIIPDFDIYYIYGFSSGNFVYFLTLQPEMISPPGSTTKEQVYTS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  279 KLVRLCKEDTAFNSYVEVPIGCERSGVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQKRKMKSLDESALCIF 358
Cdd:cd11274   241 KLVRLCKEDTAFNSYVEVPIGCEKNGVEYRLLQAAYLSKAGAILARSLGVGPDDDILFTVFSKGQKRKMKSLDESALCIF 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  359 ILKQINDRIKERLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDDNFCGLDMNAPLGVSDMVRGIPVFTEDRDRMTSVIAY 438
Cdd:cd11274   321 VLKEINDRIKDRLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDDNFCGLDMNAPLGVSEMVRGLPVFTEDRDRMTSVIAY 400

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767949001  439 VYKNHSLAFVGTKSGKLKKIRVDGPRGNALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVPVESCG 511
Cdd:cd11274   401 VYKNHSLAFVGTKSGKLKKIRVDGTTKNALQYETVQVVDTGPILRDMAFSKDHEQLYIMSEKQLTRVPVESCG 473
Sema_plexin_A cd11244
The Sema domain, a protein interacting module, of Plexin A; Plexins serve as receptors of ...
 40-508 0e+00

The Sema domain, a protein interacting module, of Plexin A; Plexins serve as receptors of semaphorins and may be the ancestor of semaphorins. Members of the Plexin A subfamily are receptors for Sema1s, Sema3s, and Sema6s, and they mediate diverse biological functions including axon guidance, cardiovascular development, and immune function. Guanylyl cyclase Gyc76C and Off-track kinase (OTK), a putative receptor tyrosine kinase, modulate Sema1a-Plexin A mediated axon repulsion. Sema3s do not interact directly with plexin A receptors, but instead bind Neuropilin-1 or Neuropilin-2 toactivate neuropilin-plexin A holoreceptor complexes. In contrast to Sema3s, Sema6s do not require neuropilins for plexin A binding. In the complex, plexin As serve as signal-transducing subunits. An increasing number of molecules that interact with the intracellular region of Plexin A have been identified; among them are IgCAMs (in axon guidance events) and Trem2-DAP12 (in immune responses). The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200505 [Multi-domain]  Cd Length: 470  Bit Score: 930.77  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001   40 FVTFRGEP-AEGFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPLTTTNNVNKML 118
Cdd:cd11244     1 FVTFRGEPrDWSFNHLTVHRRTGEVYVGAINRVYKLSSNLTVLVTHETGPVEDNPKCYPPPIVQTCNEPLTTTNNVNKLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  119 LIDYKENRLIACGSLYQGICKLLRLEDLFKLGEPYHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYFPT 198
Cdd:cd11244    81 LIDYSENRLIACGSLYQGVCKLLRLEDLFKLGEPHHKKEHYLSGVNESGTMFGVIVSYSNGDDKLFIGTAVDGKSEYFPT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  199 ISSRKLTKNSEADGMFAYVFHDEFVASMIKIPSDTFTIIPDFDIYYVYGFSSGNFVYFLTLQPEMVSPPGSTTKEQVYTS 278
Cdd:cd11244   161 LSSRKLTADEESDGMFAYVYHDEFVSSQIKIPSDTLSIIPDFDIYYVYGFSSGNFVYFLTLQPETQLTPGDSTGEQFYTS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  279 KLVRLCKEDTAFNSYVEVPIGCERSGVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQKRKMKSLDESALCIF 358
Cdd:cd11244   241 KIVRLCKDDTKFYSYVEFPIGCTRDGVEYRLLQAAYLSKPGKALAQALGISEDEDVLFTIFSKGQKNRMKPPDESALCLF 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  359 ILKQINDRIKERLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDDNFCGLDMNAPLGVSDMVRGIPVFTEDRDRMTSVIAY 438
Cdd:cd11244   321 TLKQINLRIKERLQSCYRGEGKLSLPWLLNKDLPCINAPLQIDDNFCGLDMNQPLGGSDMVEGIPLFTDDRDRMTSVAAY 400

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  439 VYKNHSLAFVGTKSGKLKKIRVDGPRGNALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVPVE 508
Cdd:cd11244   401 VYKGHSVVFVGTKSGKLKKIRVDGPPHNALQYETVQVVEGSPILRDMAFSPDHQYLYIMSERQVTRVPVE 470
Sema_plexin_A2 cd11272
The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor ...
 40-551 0e+00

The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor for class 6 semaphorins. Interactions between Plexin A2, A4 and semaphorins 6A and 6B control the lamina-restricted projection of hippocampal mossy fibers. Sema6B also repels the growth of mossy fibers in a Plexin A4 dependent manner. Plexin A2 does not suppress Sema6B function. In addition, studies have shown that Plexin A2 may be related to anxiety and other psychiatric disorders. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200533 [Multi-domain]  Cd Length: 515  Bit Score: 772.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001   40 FVTFRGEPAE-GFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPLTTTNNVNKML 118
Cdd:cd11272     1 FNTFHSENRDwTFNHLTVHQSTGAVYVGAINRVYKLSGNLTILVAHKTGPEEDNKSCYPPLIVQPCSEVLTLTNNVNKLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  119 LIDYKENRLIACGSLYQGICKLLRLEDLFKLGEPYHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYFPT 198
Cdd:cd11272    81 IIDYSENRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNKTGTMYGVIVRSEGEDGKLFIGTAVDGKQDYFPT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  199 ISSRKLTKNSEADGMFAYVFHDEFVASMIKIPSDTFTIIPDFDIYYVYGFSSGNFVYFLTLQPEmvSPPG---STTKEQV 275
Cdd:cd11272   161 LSSRKLPRDPESSAMLDYELHSDFVSSLIKIPSDTLALVSHFDIFYIYGFASGNFVYFLTVQPE--TPEGvsiNSAGDLF 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  276 YTSKLVRLCKEDTAFNSYVEVPIGCERSGVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQKRKMKSLDESAL 355
Cdd:cd11272   239 YTSRIVRLCKDDPKFHSYVSLPFGCVRGGVEYRLLQAAYLSKPGEVLARSLNITAQEDVLFAIFSKGQKQYHHPPDDSAL 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  356 CIFILKQINDRIKERLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDDNFCGLDMNAPLGVSDMVRGIPVFTEDRDRMTSV 435
Cdd:cd11272   319 CAFPIRAINAQIKERLQSCYQGEGNLELNWLLGKDVQCTKAPVPIDDNFCGLDINQPLGGSTPVEGVTLYTSSRDRLTSV 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  436 IAYVYKNHSLAFVGTKSGKLKKIRVDGPRGNALQYETVQVV-DPGPVLRDMAFSKDHEQLYIMSERQLTRVPVESCGQYQ 514
Cdd:cd11272   399 ASYVYNGYSVVFVGTKSGKLKKIRADGPPHGGVQYEMVSVFkDGSPILRDMAFSIDHKYLYVMSERQVSRVPVESCEQYT 478

                         490       500       510
                  ....*....|....*....|....*....|....*..
gi 767949001  515 SCGECLGSGDPHCGWCVLHNTCTRKERCERSKEPRRF 551
Cdd:cd11272   479 TCGECLSSGDPHCGWCALHNMCSRRDKCQRAWEPFRF 515
Sema_plexin_A1 cd11271
The Sema domain, a protein interacting module, of Plexin A1; Plexin A1 is found in both the ...
 37-508 0e+00

The Sema domain, a protein interacting module, of Plexin A1; Plexin A1 is found in both the nervous and immune systems. Its external Sema domain is also shared by semaphorin proteins. In the nervous system, Plexin A1 mediates Sema3A axon guidance function by interacting with the Sema3A coreceptor neuropilin, resulting in actin depolarization and cell repulsion. In the immune system, Plexin A1 mediates Sema6D signaling by binding to the Sema6D-Trem2-DAP12 complex on immune cells and osteoclasts to promote Rac activation and DAP12 phosphorylation. In gene profiling experiments, Plexin A1 was identified as a CIITA (class II transactivator) regulated gene in primary dendritic cells (DCs). The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200532 [Multi-domain]  Cd Length: 474  Bit Score: 624.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001   37 QRSFVTFRGePAEGFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPLTTTNNVNK 116
Cdd:cd11271     1 QPPFRTFTA-SDWSLTHLVVHNKTGEVYVGAVNRIYKLSNNLTLLRTHVTGPVEDNEKCYPPPSVQSCPHGLGTTNNVNK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  117 MLLIDYKENRLIACGSLYQGICKLLRLEDLFKLGEPYHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYF 196
Cdd:cd11271    80 LLLVDYAANRLIACGSASQGICQFLRLDDLFKLGEPHHRKEHYLSSVNESGTMSGVIIEVGNGQNKLFVGTPIDGKSEYF 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  197 PTISSRKLTKNSEADGMFAYVFHDEFVASMIKIPSDTFTIIPDFDIYYVYGFSSGNFVYFLTLQ--PEMVSPpgSTTKEQ 274
Cdd:cd11271   160 PTLSSRKLMANEENAEMFGFVYQDEFVSSQLKIPSDTLSKFPTFDIYYVYSFSSEQFVYYLTLQldTQLTSP--DSTGEQ 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  275 VYTSKLVRLCKEDTAFNSYVEVPIGCERSGVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQKRKMKSLDESA 354
Cdd:cd11271   238 FFTSKIVRLCVDDPKFYSYVEFPIGCEQDGVEYRLIQDAYLSKPGKALAKQLGISEREDILFTVFSQGQKNRVKPPKESV 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  355 LCIFILKQINDRIKERLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDDNFCGLDMNAPLGVSDMVRGIPVFTEDRDRMTS 434
Cdd:cd11271   318 LCLFTLKKIKDKIKERIQSCYRGEGKLSLPWLLNKELGCINSPLQIDDNFCGQDFNQPLGGTVTIEGTPLFVDKEDGMTS 397

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767949001  435 VIAYVYKNHSLAFVGTKSGKLKKIRVD--GPRGN-ALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVPVE 508
Cdd:cd11271   398 VAAYDYRGRTVVFAGTRSGRIKKILVDlsAPSSRpALQYENVVAHEGSPILRDLVLSPDRQYIYAMTEKQVTRVPVE 474
Sema_plexin_A3 cd11273
The Sema domain, a protein interacting module, of Plexin A3; Plexin-A3 forms a receptor ...
 53-508 0e+00

The Sema domain, a protein interacting module, of Plexin A3; Plexin-A3 forms a receptor complex with neuropilin-2 and transduces signals for class 3 semaphorins in the nervous system. Both plexins A3 and A4 are essential for normal sympathetic neuron development. They function cooperatively to regulate the migration of sympathetic neurons, and differentially to guide sympathetic axons. Both plexins A3 and A4 are not required for guiding neural crest precursors prior to reaching the sympathetic anlagen. Plexin A3 is a major driving force for intraspinal motor growth cone guidance. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200534 [Multi-domain]  Cd Length: 469  Bit Score: 616.56  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001   53 HLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPLTTTNNVNKMLLIDYKENRLIACGS 132
Cdd:cd11273    15 HLAVHRVTGEVFVGAVNRVYKLSANLTELRAHVTGPVEDNARCYPPPSVRVCAHRLAPVDNVNKLLLVDYAGNRLVACGS 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  133 LYQGICKLLRLEDLFKLGEPYHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYFPTISSRKLTKNSEADG 212
Cdd:cd11273    95 IWQGVCQFLRLEDLFKLGEPHHRKEHYLSGAQEPDSMAGVIVEQGKGPSKLFVGTAIDGKSEYFPTLSSRKLISDEDSAD 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  213 MFAYVFHDEFVASMIKIPSDTFTIIPDFDIYYVYGFSSGNFVYFLTLQPEMVSPPGSTTKEQVYTSKLVRLCKEDTAFNS 292
Cdd:cd11273   175 MFSLVYQDEFVSSQIKIPSDTLSLYPAFDIYYVYGFVSASFVYFLTLQLDTQQTLLDTAGEKFFTSKIVRMCANDTEFYS 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  293 YVEVPIGCERSGVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQKRKMKSLDESALCIFILKQINDRIKERLQ 372
Cdd:cd11273   255 YVEFPLGCSKDGVEYRLVQAAHLAKPGLLLAQALGVPEDEDVLFTIFSQGQKNRASPPRETILCLFTLSNINAHIRERIQ 334

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  373 SCYRGEGTLDLAWLKVKDIPCSSALLTIDDNFCGLDMNAPLGVSDMVRGIPVFTEDRDRMTSVIAYVYKNHSLAFVGTKS 452
Cdd:cd11273   335 SCYRGEGTLSLPWLLNKELPCINTPMQINGNFCGLVLNQPLGGLHVIEGLPLLADSTDGMASVAAYTYRQHSVVFIGTRS 414

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767949001  453 GKLKKIRVDGPRgNALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVPVE 508
Cdd:cd11273   415 GSLKKVRVDGFQ-DAHLYETVPVVDGSPILRDMVFSPDHRYIYLLSEKQVSQLPVE 469
Sema_plexin_like cd11236
The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine ...
 51-508 2.66e-126

The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine kinases; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestor of semaphorins. Ligand binding activates signal transduction pathways controlling axon guidance in the nervous system and other developmental processes including cell migration and morphogenesis, immune function, and tumor progression. Plexins are divided into four types (A-D) according to sequence similarity. In vertebrates, type A Plexins serve as the co-receptors for neuropilins to mediate the signalling of class 3 semaphorins except Sema3E, which signals through Plexin D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B. Plexin C1 serves as the receptor of Sema7A and plays regulation roles in both immune and nervous systems. This family also includes the Met and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200497 [Multi-domain]  Cd Length: 401  Bit Score: 397.86  E-value: 2.66e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001   51 FNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRiVQTCNEPLTTTNNVNKMLLIDYKENRLIAC 130
Cdd:cd11236     2 FNHLAVDNSTGRVYVGAVNRLYQLDSSLLLEAEVSTGPVLDSPLCLPPG-CCSCDHPRSPTDNYNKILLIDYSSGRLITC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  131 GSLYQGICKLLRLEDLFKLGEPYHkkeHYLSGVNESGSVFGVI-VSYSNLDDKLFIATAVDGK--PEYFPTISSRKLtkn 207
Cdd:cd11236    81 GSLYQGVCQLRNLSNISVVVERSS---TPVAANDPNASTVGFVgPGPYNNENVLYVGATYTNNgyRDYRPAVSSRSL--- 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  208 sEADGMFAyvFHDEFVASMIKIPSDTftiIPDFDIYYVYGFSSGNFVYFLTLQPEmvsppgSTTKEQVYTSKLVRLCKED 287
Cdd:cd11236   155 -PPDDDFN--AGSLTGGSAISIDDEY---RDRYSIKYVYGFSSGGFSYFVTVQRK------SVDDESPYISRLVRVCQSD 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  288 TAFNSYVEVPIGCE-RSGVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQKRKMKSLDESALCIFILKQINDR 366
Cdd:cd11236   223 SNYYSYTEVPLQCTgGDGTNYNLLQAAYVGKAGSDLARSLGISTDDDVLFGVFSKSKGPSAEPSSKSALCVFSMKDIEAA 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  367 IKErlqscyrgegtldlawlkvkdipcssalltiddnfcgldmNAPLGVSDMVRGIPVFteDRDRMTSVIAYVYKNHSLA 446
Cdd:cd11236   303 FND----------------------------------------NCPLGGGVPITTSAVL--SDSLLTSVAVTTTRNHTVA 340

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767949001  447 FVGTKSGKLKKIRVDGPRgNALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVPVE 508
Cdd:cd11236   341 FLGTSDGQLKKVVLESSS-SATQYETLLVDSGSPILPDMVFDPDGEHLYVMTPKKVTKVPVE 401
Sema_plexin_B2 cd11276
The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor ...
 52-508 1.66e-81

The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor plays important roles in neural tube closure and cerebellar granule cell development. Mice lacking Plexin B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C-Plexin B2 signaling modulates ureteric branching. Plexin B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin B2 results in renal hypoplasia and occasional double ureters. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200537 [Multi-domain]  Cd Length: 449  Bit Score: 275.89  E-value: 1.66e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001   52 NHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEpLTTTNNVNKMLLIDYKENRLIACG 131
Cdd:cd11276     9 NHLVVDPQTGRVYLGAVNALYQLDADLQLESRVETGPKKDNKKCTPPIEENQCTE-AKMTDNYNKLLLLDSANKTLVVCG 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  132 SLYQGICKLLRLEDLFKL-------GEpyhkkEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYFPTISSRKL 204
Cdd:cd11276    88 SLFKGICSLRNLSNISEViyysdtsGE-----KSFVASNDEGVSTVGLISSLKPGNDRVFFVGKGNGSNDNGKIISTRLL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  205 TKNSEADgmfayVFHDEFVASMIKIPsdtftIIPDFDIYYVYGFSSGNFVYFLTLQpemvsPPGSTTKEQVYtskLVRLC 284
Cdd:cd11276   163 QNYDDRE-----VFENYIDAATVKSA-----YVSRYTQQFRYAFEDNNYVYFLFNQ-----QLGHPDKNRTL---IARLC 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  285 KEDTAFNSYVEVPIGCERSGVEYRLLQAAYLSKAGAVLGRTLG-VHPDDDLLFTVFSkgqkRKMKSLDESALCIFILKQI 363
Cdd:cd11276   225 ENDHHYYSYTEMDLNCRDGANAYNKCQAAYVSTPGKELAQNYGnSILSDKVLFAVFS----RDEKDSGESALCMFPLKSI 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  364 NDRIKERLQSCYRGE----GTLDLAWLKVKDIPCSSALLTIDDNF-CGLD-MNAPLGVSDMVRG-IPVFTEDRDRMTSVI 436
Cdd:cd11276   301 NAKMEANREACYTGTiddrDVFYKPFHSQKDIICGSHQQKNSKSFpCGSEhLPYPLGSRDELALtAPVLQRGGLNLTAVT 380

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767949001  437 AYVYKNHSLAFVGTKSGKLKKIRVDGPrgnALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVPVE 508
Cdd:cd11276   381 VAVENGHTVAFLGTSDGRILKVHLSPD---PEEYNSILIEKNKPVNKDLVLDKTLEHLYIMTEDKVFRLPVQ 449
Sema smart00630
semaphorin domain;
51-482 1.81e-75

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 256.53  E-value: 1.81e-75
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001     51 FNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRivqtCNEPLTTTNNVNK-MLLIDYKENRLIA 129
Cdd:smart00630    1 LQHLLLDEDNGTLYVGARNRLYQLSLNLILEAELKTGPVLSSPDCEECV----SKGKDPPTDCVNYiRLLLDYNEDRLLV 76

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001    130 CGS-LYQGICKLLRLEDLFklgepyhkkehylsgvnesgsvfgvivsysnlddklfIATAVD--GKPEYFPTISSRKLTK 206
Cdd:smart00630   77 CGTnAFQPVCRLRNLGELY-------------------------------------VGTVADfsGSDPAIPRSLSVRRLK 119

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001    207 NSeadgmfaYVFHDEFVASMIKIPSDtftiipdfdIYYVYGFSSGNFVYFLTLQPEMVsppgSTTKEQVYTSKLVRLCKE 286
Cdd:smart00630  120 GT-------SGVSLRTVLYDSKWLNE---------PNFVYAFESGDFVYFFFRETAVE----DDNCGKAVHSRVARVCKN 179

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001    287 DTA--------FNSYVEVPIGC---ERSGVEYRLLQAAYLSKAGAvlgrtlgvhPDDDLLFTVFSKGQkrkmKSLDESAL 355
Cdd:smart00630  180 DVGgprsldkkWTSFLKARLECsvpGEDPFYFNELQAAFLLPPGS---------ESDDVLYGVFSTSS----NPIPGSAV 246

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001    356 CIFILKQINDRIKERLQSCYRGEGTLDL----AWLKVKDIPC-----SSALLTIDDNFCGLDMNAPLGVSDMVRGIPVFT 426
Cdd:smart00630  247 CAFSLSDINAVFNGPFKECETSTSQWLPysrgKVPYPRPGTCpnkppSSKDLPDETLNFIKSHPLMDEVVQPLTGRPLFV 326

                           410       420       430       440       450       460
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767949001    427 E--DRDRMTSVIAYV---YKNHSLAFVGTKSGKLKKIRVDGPRGN--ALQYETVQVVDPG-PVL 482
Cdd:smart00630  327 KtdSNYLLTSIAVDRvatDGNYTVLFLGTSDGRILKVVLSESSSSseSVVLEEISVFPDGsPIS 390
Sema_plexin_B cd11245
The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin ...
 51-508 1.37e-70

The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin domains, function as receptors of semaphorins and may be the ancestors of semaphorins. There are three members of the Plexin B subfamily, namely B1, B2 and B3. Plexins B1, B2 and B3 are receptors for Sema4D, Sema4C and Sema4G, and Sema5A, respectively. The activation of plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Plexin B3, the receptor of Sema5A, is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Small GTPases play important roles in plexin B signaling. Plexin B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200506 [Multi-domain]  Cd Length: 440  Bit Score: 244.07  E-value: 1.37e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001   51 FNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPlTTTNNVNKMLLIDYKENRLIAC 130
Cdd:cd11245     2 INHLAQDPQTGRLYLGAVNGLFQLSPNLQLESRADTGPKKDSPQCLPPITAAECPQA-KETDNFNKLLLVNSANGTLVVC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  131 GSLYQGICKLLRLEDLFK-LGEPYHKKE-HYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGK-PEYFPTISSRKLTKN 207
Cdd:cd11245    81 GSLFQGVCELRNLNSVNKpLYRPETPGDkQYVAANEPSVSTVGLISYFKDGLSLLFVGRGYTSSlSGGIPPITTRLLQEH 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  208 SEADgmfayVFHDEFVASMIKipsdtfTIIPDFDIYYVYGFSSGNFVYFLTLQpemvSPPGSTTKEQVYTSklvRLCKED 287
Cdd:cd11245   161 GEMD-----AFSNEVEAKLVV------GSASRYHHDFVYAFADNGYIYFLFSR----RPGTADSTKRTYIS---RLCEND 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  288 TAFNSYVEVPIGCE-RSGVEYRLLQAAYLSKAGAVLgrtlgvhpDDDLLFTVFSKGQKRKMKSLDESALCIFILKQINDR 366
Cdd:cd11245   223 HHYYSYVELPLNCTvNQENTYNLVQAAYLAKPGKVL--------NGKVLFGVFSADEASTAAPDGRSALCMYPLSSVDAR 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  367 IKERLQSCYRGEGTLD----LAWLK--VKDIPCSSALLTIDDNFCGLD-MNAPLGVSDMVRGIPVFTEDrDRMTSVIAYV 439
Cdd:cd11245   295 FERTRESCYTGEGLEDdkpeTAYIEynVKSICKTLPDKNVKAYPCGAEhTPSPLASRYPLAAKPILTRN-DMLTAVAVAV 373

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767949001  440 YKNHSLAFVGTKSGKLKKIRVDGprGNALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVPVE 508
Cdd:cd11245   374 ENGHTIAFLGDSGGQLHKVYLDP--NHTDFYSTIPGDQDSAVNKDLLFDSTLNHLYVMTGKKISKVPVQ 440
Sema cd09295
The Sema domain, a protein interacting module, of semaphorins and plexins; Both semaphorins ...
 51-508 3.78e-65

The Sema domain, a protein interacting module, of semaphorins and plexins; Both semaphorins and plexins have a Sema domain on their N-termini. Plexins function as receptors for the semaphorins. Evolutionarily, plexins may be the ancestor of semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems, and cancer. Semaphorins can be divided into 7 classes. Vertebrates have members in classes 3-7, whereas classes 1 and 2 are known only in invertebrates. Class 2 and 3 semaphorins are secreted; classes 1 and 4 through 6 are transmembrane proteins; and class 7 is membrane associated via glycosylphosphatidylinositol (GPI) linkage. Plexins are a large family of transmembrane proteins, which are divided into four types (A-D) according to sequence similarity. In vertebrates, type A plexins serve as co-receptors for neuropilins to mediate the signalling of class 3 semaphorins. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B plexins. This family also includes the MET and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves to recognize and bind receptors.


Pssm-ID: 200495 [Multi-domain]  Cd Length: 392  Bit Score: 226.70  E-value: 3.78e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001   51 FNHLVVDERTGHIYLGAVNRIYKLSSDLKVL------VTHETGPDEDNPKCYPPrivqtCNEPLTTTNNVNKMLLIDYKE 124
Cdd:cd09295     2 DDKILVSFRKDTIYVGAIARIYKVDGGGTRLllscisPELNFGFNEDQKAFCPL-----RRGKWTECINYIKVLQQKGDL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  125 NRLIACGSLY-QGICKLLRLEDLFKLGEPYHKKEHYLSGVNESGSVFGVIVsysnlDDKLFIATAVDGKPEYFPTISSRK 203
Cdd:cd09295    77 DILAVCGSNAaQPSCGSYRLDVLVELGKVRWPSGRPRCPIDNKHSNMGVNV-----DSKLYSATDHDFKDGDRPALSRRS 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  204 LTKNSeadgmfayvfhdefvaSMIKIPSDTFTiipdFDIYYVYGFSSG---NFVYFLTLQPemvsPPGSTTKEQVYTSKL 280
Cdd:cd09295   152 SNVHY----------------LRIVVDSSTGL----DEITFVYAFVSGdddDEVYFFFRQE----PVEYLKKGMVYVPRI 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  281 VRLCKEDTA--------FNSYVEVPIGCER--SGVEYRLLQAAYLSKAGAvlgrtlgvhpDDDLLFTVFSKGQkrkmKSL 350
Cdd:cd09295   208 ARVCKLDVGgchrlkkkLTSFLKADLNCSRpqSGFAFNLLQDATGDTKNL----------IQDVKFAIFSSCL----NKS 273

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  351 DESALCIFILKQINdrikerlqscyrgegtldlawlkvkdipcssalLTIDDNFCGLDmNAPLGVSDMVrgipvftedRD 430
Cdd:cd09295   274 VESAVCAYLFTDIN---------------------------------NVFDDPVEAIN-NRPLYAHQNQ---------RS 310

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  431 RMTSVIAYVYK----NHSLAFVGTKSGKLKKIRVDGPRGNALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVP 506
Cdd:cd09295   311 RLTSIAVDATKqksvGYQVVFLGLKLGSLGKALAFFFLYKGHIIEEWKVFKDSSRITNLDLSRPPLYLYVGSESGVLGVP 390


                  ..
gi 767949001  507 VE 508
Cdd:cd09295   391 VQ 392
Sema_plexin_B3 cd11277
The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of ...
 47-507 1.07e-58

The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The stimulation of plexin B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200538 [Multi-domain]  Cd Length: 434  Bit Score: 209.28  E-value: 1.07e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001   47 PAEGFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPlTTTNNVNKMLLIDYKENR 126
Cdd:cd11277     4 PNATFNHLALDPGSGTLYVGAVNRLYQLSPDLQLLGEAVTGPVLDSPDCLPFRDPADCPQA-RLTDNANKLLLVSERAGE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  127 LIACGSLYQGICKLLRLED----LFKLGEPyhkKEHYLSGVNESG-SVFGVIVSYSNLdDKLFIATAVDGK-PEYFPTIS 200
Cdd:cd11277    83 LVACGQVRQGVCEKRRLGNvaqvLYQAEDP---GDGQFVAANDPGvATVGLVVEAPGR-DLLLVGRGLTGKlSAGIPPLT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  201 SRKLTKnseadgmfAYVFHDEFVASMikipsdtftIIPDFDIY---YVYGFSSGNFVYFLtlqpemVSPPGSTTKEQvYT 277
Cdd:cd11277   159 IRQLAG--------AQAFSSEGLGKL---------VVGDFSDYnnsYVGAFAHNGYVYFL------FRRRGARAQAE-YR 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  278 SKLVRLCKEDTAFNSYVEVPIGCERSgveYRLLQAAYLSkagavlgrtlgvhPDDDLLFTVFSKGQKRKMKSLDESALCI 357
Cdd:cd11277   215 TYVARVCLGDTNLYSYVEVPLVCQGG---YNLAQAAYLA-------------PGQGTLFVVFAAGQGSTPTPTDQTALCA 278

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  358 FILKQINDRIKERLQSCYRGEGtldlawlkvKDIP--------------CSSALLTIDDNF-CGLDMN-APLGVSDMVRG 421
Cdd:cd11277   279 YPLVELDSAMERARRLCYTAGG---------GGPNgkeeatieygvtsrCVNLPKDSPESYpCGDEHTpSPIASRQPLEA 349

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  422 IPVFTeDRDRMTSVIAYVYKNHSLAFVGTKSGKLKKIRVDGPRGNAlqYETVQVVDPG-PVLRDMAFSKDHEQLYIMSER 500
Cdd:cd11277   350 EPLLT-LTPPLTAVAALQEDGHTIAFLGDTQGQLHKVFLNGSAGQV--YSSQPVGPPGsAVNPDLLLDATGSHLYVLTAR 426


                  ....*..
gi 767949001  501 QLTRVPV 507
Cdd:cd11277   427 QVTKVPV 433
Sema_plexin_B1 cd11275
The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the ...
 51-507 1.22e-57

The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D-plexin B signaling complex regulates dendritic and axonal complexity. The activation of Plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200536 [Multi-domain]  Cd Length: 461  Bit Score: 207.12  E-value: 1.22e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001   51 FNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPlTTTNNVNKMLLIDYKENRLIAC 130
Cdd:cd11275     8 FLHLSMDPESGTLYLGATNFLFQLTPDLLLENMVQTGPVLDSKDCLPPVSKLECPQA-QHTNNHNKLLLVNPVQKELIVC 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  131 GSLYQGICKLLRLEDLfklgepyhkkEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYF-------------- 196
Cdd:cd11275    87 GSVHQGICEKRRLGSI----------DHVLFRPERPGDTQYVAANDPNVTTVGLVAYSKDGVPLLFvgrgytsrgvgggi 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  197 PTISSRKLTKNSEADGMFAYVFHDEFVASMikipsdTFTIIPDFDIYYVYGFSSGNFVYFLTLQPEMVSppgsttKEQVY 276
Cdd:cd11275   157 PPITTRNLRAHGDDATDSHSIFSYEETAKL------AVGRLSEYNHHFIKAFTYGSSVYFLFYRRDLKS------QSREY 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  277 TSKLVRLCKEDTAFNSYVEVPIGCERSGVEYRLLQAAYLSKAGAVLGRTLGVhPDDDLLFTVFSKGQKRKMKSLDESALC 356
Cdd:cd11275   225 KTYISRICLDDSHYYSYVELPLLCQSKANTYSLLQAAYVTQPGERLAQGQLD-TDGEVLFAAFSAWQASSGKLSEESALC 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  357 IFILKQINDRIKERLQSCY----RGEGTLDLAWLKVkDIPCSSALL---TIDDNFCGLDMN-APLGVSDMVRGIPVFTED 428
Cdd:cd11275   304 AYPMDEVDRLTNWTRDVCYtrdgKAEDGTEVAYIEY-DVSSNCVQLpadTLDAYPCGSDHTpSPMASRVPLEATPLLEWT 382

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767949001  429 RDRMTSVIAYVYKNHSLAFVGTKSGKLKKIRVdGPRGNALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVPV 507
Cdd:cd11275   383 EIRLTAVAVNVEDGHTIAFLGDSRGRLHKVYL-GAGGDAHTYSSQSIQQNSAVSGDLLFDQLQEHLYVMTQSTVLKVPI 460
Sema_MET_like cd11248
The Sema domain, a protein interacting module, of MET and RON receptor tyrosine kinases; This ...
 54-507 4.40e-48

The Sema domain, a protein interacting module, of MET and RON receptor tyrosine kinases; This family includes MET and RON receptor tyrosine kinases. MET is encoded by the c-met protooncogene. MET is the receptor for hepatocyte growth factor/scatter factor (HGF/SF). HGF/SF and MET regulates multiple cellular events and are essential for the development of several tissues and organs, including the placenta, liver, and several groups of skeletal muscles. RON receptor tyrosine kinase is a Macrophage-stimulating protein (MSP) receptor. Upon binding of MSP, RON is activated via autophosphorylation within its kinase catalytic domain, resulting in a variety of effects including proliferation, tubular morphogenesis, angiogenesis, cellular motility and invasiveness. By interacting with downstream signaling molecules, it regulates macrophage migration, phagocytosis, and nitric oxide production. MET and RON receptors have been implicated in cancer development and migration. They are composed of alpha-beta heterodimers. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a Sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic tyrosine kinase domain. The Sema domain is necessary for receptor dimerization and activation.


Pssm-ID: 200509 [Multi-domain]  Cd Length: 467  Bit Score: 179.15  E-value: 4.40e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001   54 LVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPdEDNPKCypprivQTCN------EPLTTTNNVNKMLLID-YKENR 126
Cdd:cd11248    13 IVLNEGSTEVYVAAQNVIYALNPDLQKVWEYKTGP-VGSPDC------QTCQdcssgaDPGVPKDTDNMVLVLEtYYDDY 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  127 LIACGSLYQGICKLLRLEDLFKLGEP----YHKKE---HYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDgkPEYFP-- 197
Cdd:cd11248    86 LYSCGSTQNGVCYRHVLEDGADIQSEvhclFSKKNnspSYCPDCVASPLGTKVTNVESGRTIYFFVANSVN--SSLAGsf 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  198 ---TISSRKLtKNSEaDGmfayvFHDEFvASMIKIPS--DTFTIipdfdiYYVYGFSSGNFVYFLTLQPEMVSPPGSTtk 272
Cdd:cd11248   164 pphSISVRRL-KEDG-FG-----FLSDQ-SYLDVLPSlrDSYPI------KYVYSFHSGPFVYFLTVQRESLTKPSSA-- 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  273 eqvYTSKLVRLCKEDTAFNSYVEVPIGC------ERSGVE----YRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKG 342
Cdd:cd11248   228 ---FHTRLVRLCSSDSEIWRYREMPLECiftpkrRRRSTEedvvYNVLQAAHVSKVGADLADELGASEGDDILFGVFARS 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  343 QKRKMKSLDESALCIFILKQINDRIKERLQSC--------YRGEGtldlawlkvKDIPCSSalLTIDDNFCGLDMNA-PL 413
Cdd:cd11248   305 KPDSGEPMPNSALCAFPIKYVNDAIEKGVEKCctsglehfSGSLC---------HFQPCPT--CPGESSSCEATCKEyRT 373

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  414 GVSDMVRGIPVFT-EDRD-RMTSVIAYVYKNHSLAFVGTKSGKLKKIRVD--GPRGNAlQYEtvqvVDPGPVLRDMAFSK 489
Cdd:cd11248   374 EVTKPYQRVDLFNgQMSNvLLTSILVTTIGNHTVAHLGTSDGRVLQVVLSrsGPIPHV-NFS----LDSQPVSREVAVLS 448

                         490
                  ....*....|....*...
gi 767949001  490 DHEQLYIMSERQLTRVPV 507
Cdd:cd11248   449 SNGSLLFVTGDKITKVPL 466
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1040-1140 8.35e-47

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238586  Cd Length: 99  Bit Score: 162.59  E-value: 8.35e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001 1040 PTIVRIEPEWSIVSGNTPIAVWGTHLDLIQNPQIRAKHGGKEHINiCEVLNATEMTCQAPALALGPDHQsDLTERPEEFG 1119
Cdd:cd01181     1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRVKYGGVEKTS-CKVRNSTLMTCPAPSLALLNRSP-EPGERPVEFG 78

                          90       100
                  ....*....|....*....|.
gi 767949001 1120 FILDNVQSLLILNKTNFTYYP 1140
Cdd:cd01181    79 LDGDNVQSLLILNRTSFSYYP 99
TIG_2 pfam18020
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG ...
 708-802 1.25e-39

TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG domains have an Ig-like fold.


Pssm-ID: 465619  Cd Length: 94  Bit Score: 142.03  E-value: 1.25e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001   708 DKILVPVEVIKPITLKAKNLPQPQSGQRGYECILNIQGSEQRVPALRFNSSSVQCQNTSYSYEGMeINNLPVELTVVWNG 787
Cdd:pfam18020    1 GSILVPVGVEREITLKARNLPLFQSGQLGYECVFEIEGATHVVPASRESSDSITCQEHQFSYSGS-SGELPATFYVTWNG 79

                           90
                   ....*....|....*
gi 767949001   788 HFNIDNPAQNKVHLY 802
Cdd:pfam18020   80 GHRLDNPANLQVVLY 94
Sema_MET cd11278
The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor ...
 61-365 4.89e-39

The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR); MET is encoded by the c-met protooncogene. MET is a receptor tyrosine kinase that binds its ligand, hepatocyte growth factor/scatter factor (HGF/SF). HGF/SF and MET are essential for the development of several tissues and organs, including the placenta, liver, and several groups of skeletal muscles. It also plays a major role in the abnormal migration of cancer cells as a result of overexpression or MET mutations. MET is composed of an alpha-beta heterodimer. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a Sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic tyrosine kinase domain. The cytoplasmic C-terminal region acts as a docking site for multiple protein substrates, including Grb2, Gab1, STAT3, Shc, SHIP-1 and Src. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. The Sema domain of Met is necessary for receptor dimerization and activation.


Pssm-ID: 200539 [Multi-domain]  Cd Length: 492  Bit Score: 153.10  E-value: 4.89e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001   61 GHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPpriVQTCNEPLTTTN-----NVNKMLLI-DYKENRLIACGSLY 134
Cdd:cd11278    36 HHIYVGAVNKIYVLNEDLQKVSEYKTGPVLEHPDCFP---CQDCSDKANLSNgvwkdNVNMALFVeTYYDDQLISCGSVN 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  135 QGICKllrlEDLFKLGEPYHKKEH----YLSGVNESG--------SVFG--VIVSYSNLDDKLFIATAVDG---KPEYFP 197
Cdd:cd11278   113 RGTCQ----RHVFPHDHPADIQSEvhciYSPQIEEEPdqcpdcvvSTLGskVLVTVKDRFVNFFVGNTINSsyfPDHPLH 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  198 TISSRKLTKNSeaDGmFAYVFHDEFVasmikipsdtfTIIPDF-DIY---YVYGFSSGNFVYFLTLQPEmvsppgsTTKE 273
Cdd:cd11278   189 SISVRRLKETQ--DG-FEFLTDQSYI-----------DVLPEFrDSYpikYVHAFESNNFVYFLTVQRE-------SLDS 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  274 QVYTSKLVRLCKEDTAFNSYVEVPIGC-------ERS--GVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQK 344
Cdd:cd11278   248 QTFHTRIIRFCSIDSELRSYMEMPLECiftekrrKRStkKEVFNILQAAYVSKPGAQLAREMGASLNDDILFGVFAQSKP 327

                         330       340
                  ....*....|....*....|.
gi 767949001  345 RKMKSLDESALCIFILKQIND 365
Cdd:cd11278   328 DSAEPMNRSAVCAVSIKTINE 348
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 955-1038 1.97e-34

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 126.96  E-value: 1.97e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  955 TLSDLKPSRGPMSGGTQVTITGTNLNAGSNVVVMFGKQPCLFHRRSPSYIVCNTTSSDEVLEMKVSVQVDRAKIHQDLVF 1034
Cdd:cd01179     2 SITSLSPSYGPQSGGTRLTITGKHLNAGSSVRVTVGGQPCKILSVSSSQIVCLTPPSASPGEAPVKVLIDGARRLAPLVF 81


                  ....
gi 767949001 1035 QYVE 1038
Cdd:cd01179    82 TYTE 85
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
 310-488 4.39e-31

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 120.84  E-value: 4.39e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001   310 LQAAYLSKAGAVLGRtlgvhpdDDLLFTVFSKGQKrkmKSLDESALCIFILKQINDRIKERlqscYRGEGTLDLAWLKV- 388
Cdd:pfam01403    1 LQDVFVLKPGAGDAL-------DTVLYGVFTTQWS---NSIGGSAVCAFSLSDINAVFEGP----FKEQEKSDSKWLPYt 66

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001   389 ------KDIPC--SSALLTIDDNFCGLDMNAPLGVS--DMVRGIPVFTEDRDRMTSVIAY----VYKNHSLAFVGTKSGK 454
Cdd:pfam01403   67 gkvpypRPGTCinDPLRLDLPDSVLNFVKDHPLMDEavQPVGGRPLLVRTGVRLTSIAVDrvqaLDGNYTVLFLGTDDGR 146

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 767949001   455 LKKIrVDGPRGNALQYETVQVVDPG-PVLRDMAFS 488
Cdd:pfam01403  147 LHKV-VLVGSEESHIIEEIQVFPEPqPVLNLLLSS 180
Sema_RON cd11279
The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase; RON receptor ...
 54-507 8.47e-29

The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase; RON receptor tyrosine kinase is a Macrophage-stimulating protein (MSP) receptor. Upon binding of MSP, RON is activated via autophosphorylation within its kinase catalytic domain, resulting in a wide range of effects, including proliferation, tubular morphogenesis, angiogenesis, cellular motility and invasiveness. By interacting with downstream signaling molecules, it regulates macrophage migration, phagocytosis, and nitric oxide production. RON has been implicated in cancers of the breast, colon, pancreas and ovaries because both splice variants and receptor overexpression have been identified in these tumors. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as ligand recognition and binding model. RON is composed of an alpha-beta heterodimer. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a Sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic tyrosine kinase domain. The Sema domain of RON may be necessary for receptor dimerization and activation.


Pssm-ID: 200540 [Multi-domain]  Cd Length: 493  Bit Score: 122.20  E-value: 8.47e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001   54 LVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPdEDNPKCYPPRIVQTCNEPLTTTNNVNKMLLIDYKENRLIACGSL 133
Cdd:cd11279    32 IVSYEDASAVFVATRNHLHVLNPELKLLQNLVTGP-TGSPGCQICALCPPGPPGPSPEDTDNKVLVLDPEEPWLYSCGSS 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  134 YQGICKLLRLE---DLFKLGEP---YHKKEHYLSGVNES-GSVFG--VIVSYSNLDDKLFIATAVDGK--PEYFPT-ISS 201
Cdd:cd11279   111 LHGRCFLHELEsrgSAVHIASTaclFSANANKPSDCPDCvASPLGtrVTVVEQSHTSYFYVASTLNSSvaASYSPRsVSI 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  202 RKLtkNSEADGmFAYVFHdefvasmikipsdTFTIIPDF----DIYYVYGFSSGNFVYFLTLQPEmvSPPGSTtkeqvYT 277
Cdd:cd11279   191 RRL--KSDQDG-FAPGFH-------------SLTVLPKYldsyPIHYVHSFTSGDFVYFLTVQPE--SPDSSA-----YH 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  278 SKLVRLCKEDTAFNSYVEVPIGC------------ERSGVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQKR 345
Cdd:cd11279   248 TRLVRLSAKEPELRDYRELVLDCrfepkrrrrrrpAEREVPYNVLQAAHAAPVGSKLAVELGISEGQEVLFGVFAESQPG 327

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  346 KMKSLDESALCIFILKQINDRIKERLQSC---------YRGegtldLAWLKVK----DIPCSSALLTidDNFCgldMNAP 412
Cdd:cd11279   328 SPVPQKNSAVCAFPISLLNEAIDEGMEKCcsssnsdrlFRG-----LDFFQPQsycpHPPNLSAAVS--NTSC---WNFP 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  413 LGVSDMVRGIPVFTEDRD--RMTSVIAYVYKNHSLAFVGTKSGKLKKIRVDGPRGNALQYETVQVVDPGPVLRDMAFSKD 490
Cdd:cd11279   398 TLVSTSSFRVDLFNGHLSgvLLTSIYVTVLDNVTVAHLGTSDGRILQVVLQRSLNYLLYVSNFSLGDGQPVQRDVSRLGD 477

                         490
                  ....*....|....*..
gi 767949001  491 HeqLYIMSERQLTRVPV 507
Cdd:cd11279   478 S--LLFASGNQVFKVNI 492
Sema_plexin_D1 cd11247
The Sema domain, a protein interacting module, of Plexin D1; Plexins are known as semaphorin ...
 52-507 1.04e-27

The Sema domain, a protein interacting module, of Plexin D1; Plexins are known as semaphorin receptors and Plexin D1 has been identified as the receptor of Sema3E. It binds to Sema3E directly with high affinity. Sema3E is implicated in axonal path finding and inhibition of developmental and post-ischemic angiogenesis. Plexin D1 is broadly expressed on tumor vessels and tumor cells in a number of different types of human tumors. Plexin D1-Sema3E interaction inhibits tumor growth but promotes invasiveness and metastasis. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200508 [Multi-domain]  Cd Length: 483  Bit Score: 118.80  E-value: 1.04e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001   52 NHLVVDERTGHIYLGAVNRIYKLS-SDLKVLVTHETGPDEDNPKCYPPRIVQ-TCNEPLTTTNNVNKMLLIDYKENRLIA 129
Cdd:cd11247    12 NNFALDGGRGRLYLAAVNRLYQLSgLVLALEAEAAVGPVLDSPLCHAPQLPQaTCEHPRTLTDNYNKILQPDPEQGVLVV 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  130 CGSLYQGICKLLRLEDLFKLGEPYHKK-----EHYLS--GVNESGSVFGVIVSYSN--LDDKLFIATAVDGK-PEYF--- 196
Cdd:cd11247    92 CGSIYQGLCQLRRLYNISAVAVRFPVDgdtvfPSMLNvaANHPNASTVGLVLWPRGggGGLRLLVGATYTGYgSGFFprn 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  197 -----------PTISSRKLTKNSEADGMFAYVFHdefvasmikiPSDT--FTIIPDFDIYYVYGFSSGNFVYFltLQP-- 261
Cdd:cd11247   172 rsledhrfentPEIAIRALNTRGDLAKLFTFDIN----------PSDDniFKIKQGAKARHKLSFVRAFLQHF--LQPya 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  262 --EMVSPPGSTTKEQVYTSKLVRLCKEDTAFN----------SYVEVPIGCERSGveyrllqaaylskagavlGRTLGVH 329
Cdd:cd11247   240 ylAMNGEANAAGKESQPPSLLARICLPGRAPPppgeakklteSYIQLGLRCEGAY------------------TRLVSVF 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  330 P---DDDLLFTVFSKGQKrkmkslDESALCIFILKQINDRIKERLQSCYRGEGTLDLAWL----KVKDIPCSSAL---LT 399
Cdd:cd11247   302 ParvEEEQLFAVFERAGG------APAALCAFRFAEVEEPIRAARTACFVSPAAGVVTVLdsvvQGTGPACERKLniqLQ 375

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  400 IDDNFCG-LDMNAPLGVSDMVRGIPVFTEdrDRMTSVIAYVYKNHSLAFVGTKSGKLKKIRVDGPRgNALQYETVQVVDP 478
Cdd:cd11247   376 PEQLDCGaAHLQHPLAILQPLKATPVFRA--PGLTSVAVASVNNYTVVFLGTVSGRLLKINLDESM-QVVSRRSVTVAYG 452

                         490       500       510
                  ....*....|....*....|....*....|
gi 767949001  479 GPVLRDMAFS-KDHEQLYIMSERQLTRVPV 507
Cdd:cd11247   453 EPVHHVMQFDpSDSTYLYLMTSHQMTRVKV 482
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 858-953 1.22e-26

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 105.09  E-value: 1.22e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  858 PRITEIIPVTGPREGGTKVTIRGENLGLEFRDIASHVKVAGVECSPLVDGYIPAEQIVCEMGEAKPSQHAGFVEICVAVC 937
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRHGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNPVFNGPVEVTVGHG 80

                          90
                  ....*....|....*.
gi 767949001  938 rpEFMARSSQLYYFMT 953
Cdd:cd01180    81 --SFRTESSEGFSFVD 94
TIG_plexin pfam17960
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and ...
 564-654 5.84e-24

TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and Transcription factors) found in plexins.


Pssm-ID: 465588  Cd Length: 89  Bit Score: 96.95  E-value: 5.84e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001   564 HPNNISVSQY-NVLLVLEtyNVPELSAGVNCTFEDLSEMDGLVVGNQIQCYSPAAKEVPRIiTENGDHHVVQLQLKSKET 642
Cdd:pfam17960    1 TPDNISRTTAtQLTLTVP--NLPALSEGYSCVFGDLTESPATVHDNGVKCATPPPSQLPPI-PTGQDHVTVKLSLRSSET 77

                           90
                   ....*....|..
gi 767949001   643 GMTFASTSFVFY 654
Cdd:pfam17960   78 GVDFASTNFTFY 89
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 955-1038 2.43e-20

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 86.74  E-value: 2.43e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  955 TLSDLKPSRGPMSGGTQVTITGTNLNAGS-NVVVMFGKQPCLFHRRSPSYIVCNTTSSDEVLEMKVSVQVDRA----KIH 1029
Cdd:cd00603     2 VITSISPSSGPLSGGTRLTITGSNLGSGSpRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGEGPVEVTVDGAnvsaRVL 81


                  ....*....
gi 767949001 1030 QDLVFQYVE 1038
Cdd:cd00603    82 SNTTFTYVE 90
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 954-1038 7.76e-18

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 79.81  E-value: 7.76e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  954 LTLSDLKPSRGPMSGGTQVTITGTNLNAGSNVVVMF-GKQPCLFHRRSPSYIVCNTTSSDEVLEMKVSVQVDRA---KIH 1029
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTFgGGVPCSVLSVSSTAIVCTTPPYANPGPGPVEVTVDRGnggITS 80


                  ....*....
gi 767949001 1030 QDLVFQYVE 1038
Cdd:cd00102    81 SPLTFTYVP 89
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 858-952 2.25e-15

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 72.87  E-value: 2.25e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  858 PRITEIIPVTGPREGGTKVTIRGENLGLEFRDIAshVKVAGVECSPLVDGyipAEQIVCEMGEAKPSQHAGfVEICVAVC 937
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVR--VTVGGVPCKVLNVS---STEIVCRTPAAATPGEGP-VEVTVDGA 74

                          90
                  ....*....|....*
gi 767949001  938 RPEFMARSSQLYYFM 952
Cdd:cd00603    75 NVSARVLSNTTFTYV 89
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
510-548 1.06e-13

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 66.41  E-value: 1.06e-13
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 767949001    510 CGQYQSCGECLGSGDPHCGWCVLHNTCTRKERCERSKEP 548
Cdd:smart00423    2 CSKYTSCSECLLARDPYCAWCSSQGRCTSGERCDSRRQN 40
IPT smart00429
ig-like, plexins, transcription factors;
1039-1139 2.00e-13

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 67.06  E-value: 2.00e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001   1039 DPTIVRIEPEWSIVSGNTPIAVWGTHLDLIQNPQIRAKHGGKEhiniCEVLN--ATEMTCQAPalalgPDHQSDLTERPE 1116
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEAP----CTFSPssSTAIVCKTP-----PYHNIPGSVPVR 71

                            90       100
                    ....*....|....*....|...
gi 767949001   1117 EFGFILDNVQSLlilnKTNFTYY 1139
Cdd:smart00429   72 TVGLRNGGVPSS----PQPFTYV 90
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1040-1140 2.75e-13

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 66.71  E-value: 2.75e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001 1040 PTIVRIEPEWSIVSGNTPIAVWGTHLDLIQnPQIRAKHGGKEhiniCEVL--NATEMTCQAPALALGPdhqsdltERPEE 1117
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGS-PRVRVTVGGVP----CKVLnvSSTEIVCRTPAAATPG-------EGPVE 68

                          90       100
                  ....*....|....*....|...
gi 767949001 1118 FGFILDNVqSLLILNKTNFTYYP 1140
Cdd:cd00603    69 VTVDGANV-SARVLSNTTFTYVE 90
IPT smart00429
ig-like, plexins, transcription factors;
857-950 3.84e-13

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 66.29  E-value: 3.84e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001    857 NPRITEIIPVTGPREGGTKVTIRGENLGlEFRDIASHVKVAGVECSPLVDGyipAEQIVCEMGEAKPSQHAGFVEiCVAV 936
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLK-SISVVFVEVGVGEAPCTFSPSS---STAIVCKTPPYHNIPGSVPVR-TVGL 75

                            90
                    ....*....|....
gi 767949001    937 CRPEFMARSSQLYY 950
Cdd:smart00429   76 RNGGVPSSPQPFTY 89
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 509-551 5.37e-13

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 64.65  E-value: 5.37e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 767949001   509 SCGQYQSCGECLGSGDPHCGWCVLHNTCTRKERCERSKEPRRF 551
Cdd:pfam01437    1 RCSQYTSCSSCLAARDPYCGWCSSEGRCVRRSACGAPEGNCEE 43
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 954-1036 1.27e-12

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 64.78  E-value: 1.27e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001   954 LTLSDLKPSRGPMSGGTQVTITGTNLNAGS-NVVVMFGKQPCLFHRRSPSYIVCNTTSSDEVLeMKVSVQV-DRAKIHQD 1031
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSsDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGL-VNVSVTVgGGGISSSP 79


                   ....*
gi 767949001  1032 LVFQY 1036
Cdd:pfam01833   80 LTFTY 84
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 858-950 6.83e-12

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 62.86  E-value: 6.83e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  858 PRITEIIPVTGPREGGTKVTIRGENLGLEFRdiaSHVKV-AGVECSPLVDGyipAEQIVCEMGEAKPSQHagfVEICVAV 936
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGSN---LRVTFgGGVPCSVLSVS---STAIVCTTPPYANPGP---GPVEVTV 71

                          90
                  ....*....|....
gi 767949001  937 CRPEFMARSSQLYY 950
Cdd:cd00102    72 DRGNGGITSSPLTF 85
IPT smart00429
ig-like, plexins, transcription factors;
954-1037 1.49e-11

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 62.05  E-value: 1.49e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001    954 LTLSDLKPSRGPMSGGTQVTITGTNLNAGSNVVVMF--GKQPCLFHRRSPSYIVCNTTS-SDEVLEMKVS-VQVDRAKIH 1029
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVgvGEAPCTFSPSSSTAIVCKTPPyHNIPGSVPVRtVGLRNGGVP 81


                    ....*....
gi 767949001   1030 -QDLVFQYV 1037
Cdd:smart00429   82 sSPQPFTYV 90
RasGAP_plexin_A cd12790
Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of ...
 1311-1339 1.68e-11

Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. They are divided into four types (A-D) according to sequence similarity. In vertebrates, there are four type A plexins (A1-A4) that serve as the co-receptors for neuropilins to mediate the signaling of class 3 semaphorins except Sema3E, which signals through Plexin-D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 1 and class 6 semaphorins signal through type A plexins, which mediate diverse biological functions including axon guidance, cardiovascular development, and immune function. Guanylyl cyclase Gyc76C and Off-track kinase (OTK), a putative receptor tyrosine kinase, modulate Sema1a and Plexin-A mediated axon repulsion. In their complex with Sema6s, type A plexins serve as signal-transducing subunits. An increasing number of molecules that interact with the intracellular region of Plexin-A have been identified; among them are IgCAMs (in axon guidance events) and Trem2-DAP12 (in immune responses). Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213350 [Multi-domain]  Cd Length: 385  Bit Score: 67.83  E-value: 1.68e-11
                          10        20
                  ....*....|....*....|....*....
gi 767949001 1311 GIPFLDYRTYTMRVLFPGIEDHPVLRDLE 1339
Cdd:cd12790     1 GIPFLDYRTYAMRVLFPGIEDHPVLRELE 29
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 858-937 8.13e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 59.77  E-value: 8.13e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001   858 PRITEIIPVTGPREGGTKVTIRGENLGLEFRDIasHVKVAGVECSPLvdgYIPAEQIVCEMgeakPSQHAGFVEICVAVC 937
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDL--KVTIGGTPCTVI---SVSSTTIVCTT----PPGTSGLVNVSVTVG 71
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1040-1140 5.56e-10

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 57.47  E-value: 5.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001 1040 PTIVRIEPEWSIVSGNTPIAVWGTHLDliQNPQIRAKHGGKEHINIcEVLNATEMTCQAPALALGPDHQSDLTerpeefg 1119
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFG--SGSNLRVTFGGGVPCSV-LSVSSTAIVCTTPPYANPGPGPVEVT------- 70

                          90       100
                  ....*....|....*....|.
gi 767949001 1120 fiLDNVQSLLILNKTNFTYYP 1140
Cdd:cd00102    71 --VDRGNGGITSSPLTFTYVP 89
Sema_semaphorin cd11235
The Sema domain, a protein interacting module, of semaphorins; Semaphorins are regulator ...
 53-507 6.46e-10

The Sema domain, a protein interacting module, of semaphorins; Semaphorins are regulator molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. They can be divided into 7 classes. Vertebrates have members in classes 3-7, whereas classes 1 and 2 are known only in invertebrates. Class 2 and 3 semaphorins are secreted proteins; classes 1 and 4 through 6 are transmembrane proteins; and class 7 is membrane associated via glycosylphosphatidylinositol (GPI) linkage. The semaphorins exert their function through their receptors, the neuropilin and plexin families. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200496 [Multi-domain]  Cd Length: 437  Bit Score: 63.20  E-value: 6.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001   53 HLVVDERTGHIYLGAVNRIYKLS----SDLKVLVTHETGPDEDnpKCYPPRIVQT-CnepltttNNVNKMLLiDYKENRL 127
Cdd:cd11235     5 TKLLHEDRSTLYVGARDRVYLVDldslYTEQKVAWPSSPDDVD--TCYLKGKSKDdC-------RNFIKVLE-KNSDDSL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  128 IACGS-LYQGICKLLRLED---LFKLGE-----PYHKKEHYLSgvnesgsvfgvIVSysnlDDKLFIATAVD---GKPEY 195
Cdd:cd11235    75 LVCGTnAFNPSCRNYNVETfelVGKEESgrgkcPYDPDHNSTA-----------LFA----DGELYSGTSADflgTDPVI 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  196 FPTISSRKLTKNSEADgmfayvfhdefvasmikipsDTFTIIPDFdiyyVYGFSSGNFVYFLTLQpemVSPPGSTTKEQV 275
Cdd:cd11235   140 YRTLGHNPPLRTEYHD--------------------SKWLNEPQF----VGAFDIGDYVYFFFRE---IAVEYINCGKAV 192

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  276 YtSKLVRLCKEDT--------AFNSYVEVPIGCERSG---VEYRLLQAAYLSKAGAvlgrtlgvhPDDDLLFTVFSKgqk 344
Cdd:cd11235   193 Y-SRVARVCKNDQggsrslekKWTTFLKARLNCSVPGefpFYFNELQDVFDLPSPS---------NKEKIFYAVFTT--- 259

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  345 rKMKSLDESALCIFILKQINdrikERLQSCYRGEGTLDLAWLKVKD-IPCSSALLT-IDD--NFCGLDMN----APLgVS 416
Cdd:cd11235   260 -PYNSIPGSAVCAYSLSDIE----AVFNGPFKEQHSSNSAWLPVPDeRVPEPRPGTcVDDssPLPDDTLNfiksHPL-MD 333

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  417 DMVRGI---PVF--TEDRDRMTSVI-----AYVYKNHSLAFVGTKSGKLKKIRVdgPRGNALQ----YETVQVVDPGPVL 482
Cdd:cd11235   334 EAVTPIlnrPLFikTDVNYRFTKIAvdrvqAKLGQTYDVLFVGTDRGIILKVVS--LPEQGLQasniLEEMPVGPPPEPI 411

                         490       500
                  ....*....|....*....|....*
gi 767949001  483 RDMAFSKDHEQLYIMSERQLTRVPV 507
Cdd:cd11235   412 QTMQLSRKRRSLYVGSETGVLQVPL 436
Plexin_cytopl pfam08337
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ...
 1311-1343 2.61e-09

Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.


Pssm-ID: 462434 [Multi-domain]  Cd Length: 500  Bit Score: 61.44  E-value: 2.61e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 767949001  1311 GIPFLDYRTYTMRVLFPGIEDHPVLRDLEASVL 1343
Cdd:pfam08337    1 GIPFLDYRTYAMRVLFPGVEDHPLLVLLDVPVT 33
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 804-856 2.98e-08

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 51.17  E-value: 2.98e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767949001   804 CGAMReSCGLCLKADpDFACGWCQGPGQCTLRQHCPAQESQWLELSGAKSKCT 856
Cdd:pfam01437    2 CSQYT-SCSSCLAAR-DPYCGWCSSEGRCVRRSACGAPEGNCEEWEQASSKCP 52
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 655-702 1.04e-07

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 49.63  E-value: 1.04e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767949001   655 NCSVHNSCLSCVESP-YRCHWCKYRHVCTHdPKTCSFQEGR----VKLPEDCP 702
Cdd:pfam01437    1 RCSQYTSCSSCLAARdPYCGWCSSEGRCVR-RSACGAPEGNceewEQASSKCP 52
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 958-1038 3.03e-07

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 49.62  E-value: 3.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  958 DLKPSRGPMSGGTQVTITGTNLN---AGSNVVVMFGKQPC--LFHRRSPS-YIVCNT-TSSDEVLEMKVSVQVDR--AKI 1028
Cdd:cd01180     5 EFFPLSGPLEGGTRLTICGSNLGlrkNDVRHGVRVGGVPCnpEPPEYSSSeKIVCTTgPAGNPVFNGPVEVTVGHgsFRT 84

                          90
                  ....*....|
gi 767949001 1029 HQDLVFQYVE 1038
Cdd:cd01180    85 ESSEGFSFVD 94
Sema_2A cd11238
The Sema domain, a protein interacting module, of semaphorin 2A (Sema2A); Sema2A, a secreted ...
 51-505 4.65e-07

The Sema domain, a protein interacting module, of semaphorin 2A (Sema2A); Sema2A, a secreted semaphorin, signals through its receptor plexin B (PlexB) to regulate central and peripheral axon pathfinding. In the Drosophila embryo, Sema2A secreted by oenocytes interacts with PlexB to guide sensory axons. Sema2A is a member of the semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200499 [Multi-domain]  Cd Length: 452  Bit Score: 53.97  E-value: 4.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001   51 FNHLVVDERTGHIYLGAVNRIYKLSSDLkvlVTHETGPDEDNPKCYPPRIVQTC-----NEPLTTTNNVNKMLLIDyKEN 125
Cdd:cd11238     3 YRTLLLDEKRNALYVGAMDRVFRLNLYN---INDTGNNCARDELTLSPSDVSECvskgkDEEYECRNHVRVIQPMG-DGQ 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  126 RLIACGSlyQGICKLLRLEDLFKLGEPyhkkeHYLSGVnesGSVFGVIVSysnldDKLFIATAV---DGKPEYFPTISSR 202
Cdd:cd11238    79 TLYVCST--NAMNPKDRVLDANLLHLP-----EYVPGP---GNGIGKCPY-----DPDDNSTAVwveWGNPGDLPALYSG 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  203 KLTKNSEADgmfAYVFH--------DEFVASMIKIPSDTFTII-PDFdiyyVYGFSSGNFVYFL--TLQPEMVSPpgstt 271
Cdd:cd11238   144 TRTEFTKAN---TVIYRpplynntkGRHESFMRTLKYDSKWLDePNF----VGSFDIGDYVYFFfrETAVEYINC----- 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  272 kEQVYTSKLVRLCKEDTA--------FNSYVEVPIGCERSGvEYRL----LQAAYlskagAVLGRtlgvhpDDDLLFTVF 339
Cdd:cd11238   212 -GKVVYSRVARVCKKDTGgknvlrqnWTTFLKARLNCSISG-EFPFyfneIQSVY-----KVPGR------DDTLFYATF 278

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  340 SKGQkrkmKSLDESALCIFILKQINDRIkerLQSCYRGEGTLDLAWLKV--KDIP------CSSALLTIDDNFCGLDMNA 411
Cdd:cd11238   279 TTSE----NGFTGSAVCVFTLSDINAAF---DTGKFKEQASSSSAWLPVlsSEVPeprpgtCVNDSATLSDTVLHFARTH 351

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  412 PLGVSDMVRGIPVFTEDRDRMTSVIAYVYKNHSLAFV----GTKSGKLKKIrVDGPRGNALQYETVQV--VDPGPVLRDM 485
Cdd:cd11238   352 PLMDDAVSHGPPLLYLRDVVFTHLVVDKLRIDDQEYVvfyaGSNDGKVYKI-VHWKDAGESKSNLLDVfeLTPGEPIRAM 430

                         490       500
                  ....*....|....*....|
gi 767949001  486 AFSKdHEQLYIMSERQLTRV 505
Cdd:cd11238   431 ELLP-GEFLYVASDHRVSQI 449
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
655-702 1.14e-06

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 46.77  E-value: 1.14e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 767949001    655 NCSVHNSCLSCVESPY-RCHWCKYRHVCTHDPkTCSFQEGRVkLPEDCP 702
Cdd:smart00423    1 RCSKYTSCSECLLARDpYCAWCSSQGRCTSGE-RCDSRRQNW-LSGGCP 47
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1142-1222 1.17e-06

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 47.83  E-value: 1.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001 1142 PVFEAFGPS-GILElkPGTPIILKGKNLippvagGNVKLNYTVLVGEKPCTVT-VSDVQLLCESP--NLIGRHKVMARVG 1217
Cdd:cd00603     1 PVITSISPSsGPLS--GGTRLTITGSNL------GSGSPRVRVTVGGVPCKVLnVSSTEIVCRTPaaATPGEGPVEVTVD 72


                  ....*
gi 767949001 1218 GMEYS 1222
Cdd:cd00603    73 GANVS 77
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
806-849 1.77e-06

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 46.00  E-value: 1.77e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 767949001    806 AMRESCGLCLKAdPDFACGWCQGPGQCTLRQHCPAQESQWLELS 849
Cdd:smart00423    3 SKYTSCSECLLA-RDPYCAWCSSQGRCTSGERCDSRRQNWLSGG 45
RasGAP_plexin cd12205
Ras-GTPase Activating Domain of plexins; Plexins form a conserved family of transmembrane ...
 1311-1345 4.01e-06

Ras-GTPase Activating Domain of plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Ligand binding activates signal transduction pathways controlling axon guidance in the nervous system and other developmental processes, including cell migration and morphogenesis, immune function, and tumor progression. Plexins are divided into four types (A-D) according to sequence similarity. In vertebrates, type A Plexins serve as the co-receptors for neuropilins to mediate the signaling of class 3 semaphorins except Sema3E, which signals through Plexin D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B. Plexin C1 serves as the receptor of Sema7A and plays regulation roles in both immune and nervous systems. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Other proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213344 [Multi-domain]  Cd Length: 382  Bit Score: 50.68  E-value: 4.01e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767949001 1311 GIPFLDYRTYTMRVLFPGIEDHPVLRDLEASVLDF 1345
Cdd:cd12205     1 GIPFLDFREYIIRVLFPGVNDHPVLLSKFVHGSRR 35
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1142-1226 2.22e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 43.97  E-value: 2.22e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949001  1142 PVFEAFGPSGIlELKPGTPIILKGKNLippvagGNVKLNYTVLVGEKPCTV-TVSDVQLLCESPNL-IGRHKVMARVGGM 1219
Cdd:pfam01833    1 PVITSISPSSG-PASGGTTITITGSNF------GTDSSDLKVTIGGTPCTViSVSSTTIVCTTPPGtSGLVNVSVTVGGG 73


                   ....*..
gi 767949001  1220 EYSPGMV 1226
Cdd:pfam01833   74 GISSSPL 80
RasGAP_plexin_B1 cd12793
Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane ...
 1311-1339 1.49e-04

Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D and plexin-B1 signaling complex regulates dendritic and axonal complexity. The activation of Plexin-B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin-B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin-B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin-B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213353 [Multi-domain]  Cd Length: 394  Bit Score: 45.79  E-value: 1.49e-04
                          10        20
                  ....*....|....*....|....*....
gi 767949001 1311 GIPFLDYRTYTMRVLFPGIEDHPVLRDLE 1339
Cdd:cd12793     1 GIPFLDYRMYAERIFFPGHRESPLRRDLD 29
PSI_integrin pfam17205
Integrin plexin domain; This short disulphide rich domain is found at the N-terminus of ...
 508-542 1.72e-04

Integrin plexin domain; This short disulphide rich domain is found at the N-terminus of integrin beta chains.


Pssm-ID: 465380  Cd Length: 47  Bit Score: 40.61  E-value: 1.72e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 767949001   508 ESC-GQYQSCGECLGSGdPHCGWCVLHNTCTRKERC 542
Cdd:pfam17205    1 NRCtSASTSCEECIQSG-PDCAWCTDENFTSGSPRC 35
RasGAP_plexin_B3 cd12791
Ras-GTPase Activating Domain of plexin-B3; Plexins form a conserved family of transmembrane ...
 1311-1339 1.74e-04

Ras-GTPase Activating Domain of plexin-B3; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin-B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin-B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The protein and mRNA expression of Sema5A and its receptor plexin-B3 increased gradually in non-neoplastic mucosa, primary gastric carcinoma, and lymph node metastasis, and their expression is correlated. The stimulation of plexin-B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213351 [Multi-domain]  Cd Length: 397  Bit Score: 45.60  E-value: 1.74e-04
                          10        20
                  ....*....|....*....|....*....
gi 767949001 1311 GIPFLDYRTYTMRVLFPGIEDHPVLRDLE 1339
Cdd:cd12791     1 GIPFLDYRTYAERVFFPGHGGCPLQPSLE 29
RasGAP_plexin_B cd12787
Ras-GTPase Activating Domain of type B plexins; Plexins form a conserved family of ...
 1311-1344 2.61e-04

Ras-GTPase Activating Domain of type B plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity.There are three members of the Plexin-B subfamily, namely B1, B2 and B3. Plexins-B1, B2 and B3 are receptors for Sema4D, Sema4C and Sema4G, and Sema5A, respectively. The activation of plexin-B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. By signaling the effect of Sema4C and Sema4G, the plexin-B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Plexin-B3, the receptor of Sema5A, is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin-B3 has been linked to verbal performance and white matter volume in human brain. Small GTPases play important roles in plexin-B signaling. Plexin-B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin-B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213347 [Multi-domain]  Cd Length: 391  Bit Score: 45.30  E-value: 2.61e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 767949001 1311 GIPFLDYRTYTMRVLFPGIEDHPVLRDLEASVLD 1344
Cdd:cd12787     1 GIPFLDYKTYAERVFFPGHKDGPLDVMIKLDIPE 34
IPT smart00429
ig-like, plexins, transcription factors;
1141-1204 3.37e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 40.87  E-value: 3.37e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767949001   1141 NPVFEAFGP-SGILElkPGTPIILKGKNLIPpvaGGNVKlnYTVLVGEKPCTVT-VSDVQLLCESP 1204
Cdd:smart00429    1 DPVITRISPtSGPVS--GGTEITLCGKNLKS---ISVVF--VEVGVGEAPCTFSpSSSTAIVCKTP 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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