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DENN domain-containing protein 3 isoform X1 [Homo sapiens]
DENN and dDENN domain-containing protein( domain architecture ID 13071475)
protein containing domains DENN, dDENN, and WD40
List of domain hits
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Name | Accession | Description | Interval | E-value | ||||
DENN | pfam02141 | DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ... |
185-371 | 2.68e-52 | ||||
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways. : Pssm-ID: 460461 Cd Length: 186 Bit Score: 181.62 E-value: 2.68e-52
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dDENN | smart00801 | Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ... |
435-497 | 1.07e-13 | ||||
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity. : Pssm-ID: 129037 Cd Length: 69 Bit Score: 66.93 E-value: 1.07e-13
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WD40 super family | cl29593 | WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1019-1120 | 6.19e-07 | ||||
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment. The actual alignment was detected with superfamily member cd00200: Pssm-ID: 475233 [Multi-domain] Cd Length: 289 Bit Score: 52.72 E-value: 6.19e-07
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uDENN super family | cl04085 | uDENN domain; This region is always found associated with pfam02141. It is predicted to form ... |
108-158 | 2.54e-04 | ||||
uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain. The actual alignment was detected with superfamily member pfam03456: Pssm-ID: 470944 Cd Length: 59 Bit Score: 40.29 E-value: 2.54e-04
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Name | Accession | Description | Interval | E-value | ||||
DENN | pfam02141 | DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ... |
185-371 | 2.68e-52 | ||||
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways. Pssm-ID: 460461 Cd Length: 186 Bit Score: 181.62 E-value: 2.68e-52
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DENN | smart00799 | Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ... |
186-371 | 1.28e-49 | ||||
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity. Pssm-ID: 214823 Cd Length: 183 Bit Score: 173.92 E-value: 1.28e-49
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dDENN | smart00801 | Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ... |
435-497 | 1.07e-13 | ||||
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity. Pssm-ID: 129037 Cd Length: 69 Bit Score: 66.93 E-value: 1.07e-13
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WD40 | cd00200 | WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1019-1120 | 6.19e-07 | ||||
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment. Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 52.72 E-value: 6.19e-07
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WD40 | COG2319 | WD40 repeat [General function prediction only]; |
1004-1117 | 9.10e-06 | ||||
WD40 repeat [General function prediction only]; Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 49.52 E-value: 9.10e-06
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dDENN | pfam03455 | dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ... |
464-501 | 1.71e-04 | ||||
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4. Pssm-ID: 460925 Cd Length: 48 Bit Score: 40.25 E-value: 1.71e-04
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uDENN | pfam03456 | uDENN domain; This region is always found associated with pfam02141. It is predicted to form ... |
108-158 | 2.54e-04 | ||||
uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain. Pssm-ID: 460926 Cd Length: 59 Bit Score: 40.29 E-value: 2.54e-04
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Name | Accession | Description | Interval | E-value | ||||
DENN | pfam02141 | DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ... |
185-371 | 2.68e-52 | ||||
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways. Pssm-ID: 460461 Cd Length: 186 Bit Score: 181.62 E-value: 2.68e-52
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DENN | smart00799 | Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ... |
186-371 | 1.28e-49 | ||||
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity. Pssm-ID: 214823 Cd Length: 183 Bit Score: 173.92 E-value: 1.28e-49
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dDENN | smart00801 | Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ... |
435-497 | 1.07e-13 | ||||
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity. Pssm-ID: 129037 Cd Length: 69 Bit Score: 66.93 E-value: 1.07e-13
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WD40 | cd00200 | WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1019-1120 | 6.19e-07 | ||||
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment. Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 52.72 E-value: 6.19e-07
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WD40 | cd00200 | WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
982-1186 | 1.87e-06 | ||||
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment. Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 51.18 E-value: 1.87e-06
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WD40 | cd00200 | WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
981-1134 | 4.87e-06 | ||||
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment. Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 50.03 E-value: 4.87e-06
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WD40 | COG2319 | WD40 repeat [General function prediction only]; |
1004-1117 | 9.10e-06 | ||||
WD40 repeat [General function prediction only]; Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 49.52 E-value: 9.10e-06
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WD40 | COG2319 | WD40 repeat [General function prediction only]; |
1004-1120 | 2.36e-05 | ||||
WD40 repeat [General function prediction only]; Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 48.37 E-value: 2.36e-05
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WD40 | COG2319 | WD40 repeat [General function prediction only]; |
997-1187 | 2.36e-05 | ||||
WD40 repeat [General function prediction only]; Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 48.37 E-value: 2.36e-05
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WD40 | cd00200 | WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1002-1097 | 2.68e-05 | ||||
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment. Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 47.71 E-value: 2.68e-05
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WD40 | COG2319 | WD40 repeat [General function prediction only]; |
1004-1120 | 3.87e-05 | ||||
WD40 repeat [General function prediction only]; Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 47.60 E-value: 3.87e-05
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dDENN | pfam03455 | dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ... |
464-501 | 1.71e-04 | ||||
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4. Pssm-ID: 460925 Cd Length: 48 Bit Score: 40.25 E-value: 1.71e-04
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uDENN | pfam03456 | uDENN domain; This region is always found associated with pfam02141. It is predicted to form ... |
108-158 | 2.54e-04 | ||||
uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain. Pssm-ID: 460926 Cd Length: 59 Bit Score: 40.29 E-value: 2.54e-04
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WD40 | COG2319 | WD40 repeat [General function prediction only]; |
1000-1117 | 6.79e-04 | ||||
WD40 repeat [General function prediction only]; Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 43.75 E-value: 6.79e-04
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SPA | pfam08616 | Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque ... |
283-377 | 4.67e-03 | ||||
Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque of the spindle pole body. In Aspergillus nidulans the protein member is necessary for stabilization of the polarity axes during septation. and in S. cerevisiae it functions as a polarization-specific docking factor. Pssm-ID: 400783 Cd Length: 113 Bit Score: 38.04 E-value: 4.67e-03
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WD40 | cd00200 | WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1058-1132 | 5.66e-03 | ||||
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment. Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 40.40 E-value: 5.66e-03
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Blast search parameters | ||||
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