regulator of G-protein signaling 22 isoform X10 [Homo sapiens]
Protein Classification
regulator of G-protein signaling domain-containing protein( domain architecture ID 446)
regulator of G-protein signaling (RGS) domain-containing protein belongs to a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs)
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| RGS super family | cl02565 | Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ... |
670-722 | 3.35e-28 | ||
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision. The actual alignment was detected with superfamily member cd08727: Pssm-ID: 470619 Cd Length: 116 Bit Score: 109.45 E-value: 3.35e-28
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| Name | Accession | Description | Interval | E-value | ||
| RGS_RGS22_2 | cd08727 | Regulator of G protein signaling domain RGS_RGS22_2; The RGS (Regulator of G-protein Signaling) ... |
670-722 | 3.35e-28 | ||
Regulator of G protein signaling domain RGS_RGS22_2; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis. Pssm-ID: 188682 Cd Length: 116 Bit Score: 109.45 E-value: 3.35e-28
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| Name | Accession | Description | Interval | E-value | ||
| RGS_RGS22_2 | cd08727 | Regulator of G protein signaling domain RGS_RGS22_2; The RGS (Regulator of G-protein Signaling) ... |
670-722 | 3.35e-28 | ||
Regulator of G protein signaling domain RGS_RGS22_2; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis. Pssm-ID: 188682 Cd Length: 116 Bit Score: 109.45 E-value: 3.35e-28
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