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Conserved domains on  [gi|767952814|ref|XP_011515264|]
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mdm2-binding protein isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MTBP_mid pfam14919
MDM2-binding; MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its ...
 294-632 0e+00

MDM2-binding; MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its interaction with p53, plays an important role in the regulation of the G1 checkpoint of the cell cycle. MTBP promotes MDM2-mediated ubiquitination and degradation of p53 and also MDM2 stabilization in an MDM2 RING finger-dependent manner. MTBP differentially regulates the E3 ubiquitin ligase activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells. MTBP inhibits cancer cell migration by interacting with a protein involved in cell motility. This motility protein is alpha-actinin-4 (ACTN4). It is unclear which regions of MTBP interact with which binding-partner. See PF14918, PF14920.


:

Pssm-ID: 464375  Cd Length: 336  Bit Score: 619.73  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952814  294 KVFHYYGPALEFVQMIKLSDLPSCYMSDIEFELGLT-NSTKQNSVLLLEQISSLCSKVGALFVLPCTISNILIPPPNQLS 372
Cdd:pfam14919   1 EVFHYYGPVLDFVQMVKLSDLPSFLMSDSEFELGLTrNNKSQKSKLLLDQLSSLRGKVGALFSLPCTVSNIAIPPASQLS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952814  373 SRKWKEYIAKKPKTISVPDVEVKGECSSYYLLLQGNGNRRCKATLIHSANQINGSFALNLIHGKMKTKTEEAKLSFPFD- 451
Cdd:pfam14919  81 SRKWKEYMAKKPKSISVPDVEVKGESASYYLLVQGNGSGGCKATLLHSASQINGAAALATIHGKLLRETEEASSGFPVDn 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952814  452 -LLSLPHFSGEQIVQREKQLANVQVLALEECLKRRKLAKQPETVSVAELKSLLVLTRKHFLDYFDAVIPKMILRKMDKIK 530
Cdd:pfam14919 161 fLRSLPCLSGEQLVQRERKLAQVQALALKEYLRRRELAKQPSSVSVNELKSLLNLTREQYLKMFDSSLPKAALKQQNCLT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952814  531 TFNILNDFSPVEPnssslmETNPLEWPERHVLQNLETFEKTKQKMRTGSLPHSSEQLLGHKEGPRDSITLLDAKELLKYF 610
Cdd:pfam14919 241 TSQMLNSSELVEL------ETNPLEWPERSVLQNLENLEKAKQKMRTGLLPGSSEQLLGPKDGQRGSSTLLDAKELLKHF 314

                         330       340
                  ....*....|....*....|..
gi 767952814  611 TSDGLPIGDLQPLPIQKGEKTF 632
Cdd:pfam14919 315 TSDGLPVGDLQPLQIQRGENAF 336
MTBP_N pfam14918
MDM2-binding; MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its ...
 1-270 2.72e-156

MDM2-binding; MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its interaction with p53, plays an important role in the regulation of the G1 checkpoint of the cell cycle. MTBP promotes MDM2-mediated ubiquitination and degradation of p53 and also MDM2 stabilization in an MDM2 RING finger-dependent manner. MTBP differentially regulates the E3 ubiquitin ligase activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells. MTBP inhibits cancer cell migration by interacting with a protein involved in cell motility. This motility protein is alpha-actinin-4 (ACTN4). It is unclear which regions of MTBP interact with which binding-partner. See PF14919, PF14920.


:

Pssm-ID: 464374  Cd Length: 254  Bit Score: 450.35  E-value: 2.72e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952814    1 MDRYLLLVIWgegkfpsaasrEAEHGPEVSSGEGTENQPdftaANVYHLLKRSISASINPEDSTFPACSVGGIPGSKKWF 80
Cdd:pfam14918   1 MDRYVLLIIW-----------ERRFDGEFSSFSGLEETP----ENVYELLKRISTVSSNKYDSTFPACSLTGIPGSRKWF 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952814   81 FAVQAIYGFYQFCSSDWQEIHFDTEKDKIEDVLQTNIEECLGAVECFEEEDSNSRESLSLADLYEEAAENLHQLSDKLPA 160
Cdd:pfam14918  66 FAVQAICGSFQFCSSDWEELHFDSEKDDIEESLQTALEECLSALQCQEEEDSNSRESLSLTDLFEEAAENLHQLSDKLPA 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952814  161 PGRAMVDIILLLSDKDPPKLKDYLPTVGALKHLREWYSAKITIAGNHCEInCQKIAEYLSANVVSLEDLRNVIDSKELWR 240
Cdd:pfam14918 146 PGRAMLDVILLCSEPDTPKLKDCLPLIGALKHLKEWHSAKITIVTNHCEG-WQKIAGYLSATVVSLSDIKSCIDSRELWR 224

                         250       260       270
                  ....*....|....*....|....*....|
gi 767952814  241 GKIQIWERKFGFEISFPEFCLKGVTLKNFS 270
Cdd:pfam14918 225 GKIQIWERKFGSEVSFPEFCLRQVSPEKFL 254
MTBP_C super family cl20806
MDM2-binding; MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its ...
 636-660 3.09e-10

MDM2-binding; MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its interaction with p53, plays an important role in the regulation of the G1 checkpoint of the cell cycle. MTBP promotes MDM2-mediated ubiquitination and degradation of p53 and also MDM2 stabilization in an MDM2 RING finger-dependent manner. MTBP differentially regulates the E3 ubiquitin ligase activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells. MTBP inhibits cancer cell migration by interacting with a protein involved in cell motility. This motility protein is alpha-actinin-4 (ACTN4). It is unclear which regions of MTBP interact with which binding-partner. See PF14918, PF14919.


The actual alignment was detected with superfamily member pfam14920:

Pssm-ID: 464376  Cd Length: 257  Bit Score: 61.28  E-value: 3.09e-10
                          10        20
                  ....*....|....*....|....*
gi 767952814  636 PELSPGKLQVLPFEKASVCHYHGIE 660
Cdd:pfam14920   1 PELSPRKLRILPFEKASVCHYHGIE 25
 
Name Accession Description Interval E-value
MTBP_mid pfam14919
MDM2-binding; MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its ...
 294-632 0e+00

MDM2-binding; MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its interaction with p53, plays an important role in the regulation of the G1 checkpoint of the cell cycle. MTBP promotes MDM2-mediated ubiquitination and degradation of p53 and also MDM2 stabilization in an MDM2 RING finger-dependent manner. MTBP differentially regulates the E3 ubiquitin ligase activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells. MTBP inhibits cancer cell migration by interacting with a protein involved in cell motility. This motility protein is alpha-actinin-4 (ACTN4). It is unclear which regions of MTBP interact with which binding-partner. See PF14918, PF14920.


Pssm-ID: 464375  Cd Length: 336  Bit Score: 619.73  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952814  294 KVFHYYGPALEFVQMIKLSDLPSCYMSDIEFELGLT-NSTKQNSVLLLEQISSLCSKVGALFVLPCTISNILIPPPNQLS 372
Cdd:pfam14919   1 EVFHYYGPVLDFVQMVKLSDLPSFLMSDSEFELGLTrNNKSQKSKLLLDQLSSLRGKVGALFSLPCTVSNIAIPPASQLS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952814  373 SRKWKEYIAKKPKTISVPDVEVKGECSSYYLLLQGNGNRRCKATLIHSANQINGSFALNLIHGKMKTKTEEAKLSFPFD- 451
Cdd:pfam14919  81 SRKWKEYMAKKPKSISVPDVEVKGESASYYLLVQGNGSGGCKATLLHSASQINGAAALATIHGKLLRETEEASSGFPVDn 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952814  452 -LLSLPHFSGEQIVQREKQLANVQVLALEECLKRRKLAKQPETVSVAELKSLLVLTRKHFLDYFDAVIPKMILRKMDKIK 530
Cdd:pfam14919 161 fLRSLPCLSGEQLVQRERKLAQVQALALKEYLRRRELAKQPSSVSVNELKSLLNLTREQYLKMFDSSLPKAALKQQNCLT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952814  531 TFNILNDFSPVEPnssslmETNPLEWPERHVLQNLETFEKTKQKMRTGSLPHSSEQLLGHKEGPRDSITLLDAKELLKYF 610
Cdd:pfam14919 241 TSQMLNSSELVEL------ETNPLEWPERSVLQNLENLEKAKQKMRTGLLPGSSEQLLGPKDGQRGSSTLLDAKELLKHF 314

                         330       340
                  ....*....|....*....|..
gi 767952814  611 TSDGLPIGDLQPLPIQKGEKTF 632
Cdd:pfam14919 315 TSDGLPVGDLQPLQIQRGENAF 336
MTBP_N pfam14918
MDM2-binding; MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its ...
 1-270 2.72e-156

MDM2-binding; MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its interaction with p53, plays an important role in the regulation of the G1 checkpoint of the cell cycle. MTBP promotes MDM2-mediated ubiquitination and degradation of p53 and also MDM2 stabilization in an MDM2 RING finger-dependent manner. MTBP differentially regulates the E3 ubiquitin ligase activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells. MTBP inhibits cancer cell migration by interacting with a protein involved in cell motility. This motility protein is alpha-actinin-4 (ACTN4). It is unclear which regions of MTBP interact with which binding-partner. See PF14919, PF14920.


Pssm-ID: 464374  Cd Length: 254  Bit Score: 450.35  E-value: 2.72e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952814    1 MDRYLLLVIWgegkfpsaasrEAEHGPEVSSGEGTENQPdftaANVYHLLKRSISASINPEDSTFPACSVGGIPGSKKWF 80
Cdd:pfam14918   1 MDRYVLLIIW-----------ERRFDGEFSSFSGLEETP----ENVYELLKRISTVSSNKYDSTFPACSLTGIPGSRKWF 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952814   81 FAVQAIYGFYQFCSSDWQEIHFDTEKDKIEDVLQTNIEECLGAVECFEEEDSNSRESLSLADLYEEAAENLHQLSDKLPA 160
Cdd:pfam14918  66 FAVQAICGSFQFCSSDWEELHFDSEKDDIEESLQTALEECLSALQCQEEEDSNSRESLSLTDLFEEAAENLHQLSDKLPA 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952814  161 PGRAMVDIILLLSDKDPPKLKDYLPTVGALKHLREWYSAKITIAGNHCEInCQKIAEYLSANVVSLEDLRNVIDSKELWR 240
Cdd:pfam14918 146 PGRAMLDVILLCSEPDTPKLKDCLPLIGALKHLKEWHSAKITIVTNHCEG-WQKIAGYLSATVVSLSDIKSCIDSRELWR 224

                         250       260       270
                  ....*....|....*....|....*....|
gi 767952814  241 GKIQIWERKFGFEISFPEFCLKGVTLKNFS 270
Cdd:pfam14918 225 GKIQIWERKFGSEVSFPEFCLRQVSPEKFL 254
MTBP_C pfam14920
MDM2-binding; MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its ...
 636-660 3.09e-10

MDM2-binding; MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its interaction with p53, plays an important role in the regulation of the G1 checkpoint of the cell cycle. MTBP promotes MDM2-mediated ubiquitination and degradation of p53 and also MDM2 stabilization in an MDM2 RING finger-dependent manner. MTBP differentially regulates the E3 ubiquitin ligase activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells. MTBP inhibits cancer cell migration by interacting with a protein involved in cell motility. This motility protein is alpha-actinin-4 (ACTN4). It is unclear which regions of MTBP interact with which binding-partner. See PF14918, PF14919.


Pssm-ID: 464376  Cd Length: 257  Bit Score: 61.28  E-value: 3.09e-10
                          10        20
                  ....*....|....*....|....*
gi 767952814  636 PELSPGKLQVLPFEKASVCHYHGIE 660
Cdd:pfam14920   1 PELSPRKLRILPFEKASVCHYHGIE 25
 
Name Accession Description Interval E-value
MTBP_mid pfam14919
MDM2-binding; MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its ...
 294-632 0e+00

MDM2-binding; MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its interaction with p53, plays an important role in the regulation of the G1 checkpoint of the cell cycle. MTBP promotes MDM2-mediated ubiquitination and degradation of p53 and also MDM2 stabilization in an MDM2 RING finger-dependent manner. MTBP differentially regulates the E3 ubiquitin ligase activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells. MTBP inhibits cancer cell migration by interacting with a protein involved in cell motility. This motility protein is alpha-actinin-4 (ACTN4). It is unclear which regions of MTBP interact with which binding-partner. See PF14918, PF14920.


Pssm-ID: 464375  Cd Length: 336  Bit Score: 619.73  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952814  294 KVFHYYGPALEFVQMIKLSDLPSCYMSDIEFELGLT-NSTKQNSVLLLEQISSLCSKVGALFVLPCTISNILIPPPNQLS 372
Cdd:pfam14919   1 EVFHYYGPVLDFVQMVKLSDLPSFLMSDSEFELGLTrNNKSQKSKLLLDQLSSLRGKVGALFSLPCTVSNIAIPPASQLS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952814  373 SRKWKEYIAKKPKTISVPDVEVKGECSSYYLLLQGNGNRRCKATLIHSANQINGSFALNLIHGKMKTKTEEAKLSFPFD- 451
Cdd:pfam14919  81 SRKWKEYMAKKPKSISVPDVEVKGESASYYLLVQGNGSGGCKATLLHSASQINGAAALATIHGKLLRETEEASSGFPVDn 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952814  452 -LLSLPHFSGEQIVQREKQLANVQVLALEECLKRRKLAKQPETVSVAELKSLLVLTRKHFLDYFDAVIPKMILRKMDKIK 530
Cdd:pfam14919 161 fLRSLPCLSGEQLVQRERKLAQVQALALKEYLRRRELAKQPSSVSVNELKSLLNLTREQYLKMFDSSLPKAALKQQNCLT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952814  531 TFNILNDFSPVEPnssslmETNPLEWPERHVLQNLETFEKTKQKMRTGSLPHSSEQLLGHKEGPRDSITLLDAKELLKYF 610
Cdd:pfam14919 241 TSQMLNSSELVEL------ETNPLEWPERSVLQNLENLEKAKQKMRTGLLPGSSEQLLGPKDGQRGSSTLLDAKELLKHF 314

                         330       340
                  ....*....|....*....|..
gi 767952814  611 TSDGLPIGDLQPLPIQKGEKTF 632
Cdd:pfam14919 315 TSDGLPVGDLQPLQIQRGENAF 336
MTBP_N pfam14918
MDM2-binding; MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its ...
 1-270 2.72e-156

MDM2-binding; MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its interaction with p53, plays an important role in the regulation of the G1 checkpoint of the cell cycle. MTBP promotes MDM2-mediated ubiquitination and degradation of p53 and also MDM2 stabilization in an MDM2 RING finger-dependent manner. MTBP differentially regulates the E3 ubiquitin ligase activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells. MTBP inhibits cancer cell migration by interacting with a protein involved in cell motility. This motility protein is alpha-actinin-4 (ACTN4). It is unclear which regions of MTBP interact with which binding-partner. See PF14919, PF14920.


Pssm-ID: 464374  Cd Length: 254  Bit Score: 450.35  E-value: 2.72e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952814    1 MDRYLLLVIWgegkfpsaasrEAEHGPEVSSGEGTENQPdftaANVYHLLKRSISASINPEDSTFPACSVGGIPGSKKWF 80
Cdd:pfam14918   1 MDRYVLLIIW-----------ERRFDGEFSSFSGLEETP----ENVYELLKRISTVSSNKYDSTFPACSLTGIPGSRKWF 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952814   81 FAVQAIYGFYQFCSSDWQEIHFDTEKDKIEDVLQTNIEECLGAVECFEEEDSNSRESLSLADLYEEAAENLHQLSDKLPA 160
Cdd:pfam14918  66 FAVQAICGSFQFCSSDWEELHFDSEKDDIEESLQTALEECLSALQCQEEEDSNSRESLSLTDLFEEAAENLHQLSDKLPA 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952814  161 PGRAMVDIILLLSDKDPPKLKDYLPTVGALKHLREWYSAKITIAGNHCEInCQKIAEYLSANVVSLEDLRNVIDSKELWR 240
Cdd:pfam14918 146 PGRAMLDVILLCSEPDTPKLKDCLPLIGALKHLKEWHSAKITIVTNHCEG-WQKIAGYLSATVVSLSDIKSCIDSRELWR 224

                         250       260       270
                  ....*....|....*....|....*....|
gi 767952814  241 GKIQIWERKFGFEISFPEFCLKGVTLKNFS 270
Cdd:pfam14918 225 GKIQIWERKFGSEVSFPEFCLRQVSPEKFL 254
MTBP_C pfam14920
MDM2-binding; MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its ...
 636-660 3.09e-10

MDM2-binding; MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its interaction with p53, plays an important role in the regulation of the G1 checkpoint of the cell cycle. MTBP promotes MDM2-mediated ubiquitination and degradation of p53 and also MDM2 stabilization in an MDM2 RING finger-dependent manner. MTBP differentially regulates the E3 ubiquitin ligase activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells. MTBP inhibits cancer cell migration by interacting with a protein involved in cell motility. This motility protein is alpha-actinin-4 (ACTN4). It is unclear which regions of MTBP interact with which binding-partner. See PF14918, PF14919.


Pssm-ID: 464376  Cd Length: 257  Bit Score: 61.28  E-value: 3.09e-10
                          10        20
                  ....*....|....*....|....*
gi 767952814  636 PELSPGKLQVLPFEKASVCHYHGIE 660
Cdd:pfam14920   1 PELSPRKLRILPFEKASVCHYHGIE 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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