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Conserved domains on  [gi|767953332|ref|XP_011515481|]
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solute carrier family 45 member 4 isoform X13 [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 304-516 1.72e-55

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17313:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 421  Bit Score: 194.00  E-value: 1.72e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953332 304 LWLSMLKMPRELMRLCLCHLLTWFSVIAEAVFYTDFMGQVIFEGdpkapsNSTAWQAYNAGVKMGCWGLVIYAATGAICS 383
Cdd:cd17313  225 LLKLLKIMPRSLLRLLLVIFFWWIAFFPFELFFTDYMGEEVYHG------TSAASSHYGAGVRMGAWGLLIFSLAFLIFS 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953332 384 ALLQKYLDNYdlSVRVIYVLGTLGFSVGTAVMAMFPNVYVAMVTISTMGIVSMSISYCPYALLGQYHDikqyihhspgNS 463
Cdd:cd17313  299 LPIGKLGKKI--GRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHS----------ES 366

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767953332 464 KRGFGIDCAILSCQVYISQILVASALGGV--VDAVGTVRVIPMVASVGSFLGFLT 516
Cdd:cd17313  367 GRGQGTDTGLLNLAISLAQILVSLLAGPIidVKGYGTVFPVAAVASFLSLVGALF 421
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-77 6.35e-19

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17313:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 421  Bit Score: 89.61  E-value: 6.35e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767953332   1 MALNIHAFSAGLGGAIGYVLGGLDWTQTFLGSWFRTQNQVLFFFAAIIFTVSVALHLFSIDEEQYSPQQERSAEEPG 77
Cdd:cd17313  141 KANGIINFMGGLGGVLGYLLGAILWDHNWFGFALGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSPEAGEHSENPS 217
 
Name Accession Description Interval E-value
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 304-516 1.72e-55

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 194.00  E-value: 1.72e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953332 304 LWLSMLKMPRELMRLCLCHLLTWFSVIAEAVFYTDFMGQVIFEGdpkapsNSTAWQAYNAGVKMGCWGLVIYAATGAICS 383
Cdd:cd17313  225 LLKLLKIMPRSLLRLLLVIFFWWIAFFPFELFFTDYMGEEVYHG------TSAASSHYGAGVRMGAWGLLIFSLAFLIFS 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953332 384 ALLQKYLDNYdlSVRVIYVLGTLGFSVGTAVMAMFPNVYVAMVTISTMGIVSMSISYCPYALLGQYHDikqyihhspgNS 463
Cdd:cd17313  299 LPIGKLGKKI--GRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHS----------ES 366

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767953332 464 KRGFGIDCAILSCQVYISQILVASALGGV--VDAVGTVRVIPMVASVGSFLGFLT 516
Cdd:cd17313  367 GRGQGTDTGLLNLAISLAQILVSLLAGPIidVKGYGTVFPVAAVASFLSLVGALF 421
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 1-77 6.35e-19

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 89.61  E-value: 6.35e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767953332   1 MALNIHAFSAGLGGAIGYVLGGLDWTQTFLGSWFRTQNQVLFFFAAIIFTVSVALHLFSIDEEQYSPQQERSAEEPG 77
Cdd:cd17313  141 KANGIINFMGGLGGVLGYLLGAILWDHNWFGFALGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSPEAGEHSENPS 217
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
306-533 6.05e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 49.13  E-value: 6.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953332 306 LSMLKMPRELMRLCLCHLLTWFSVIAEAVFYTDFMGQVIfegdpkapSNSTAWQAynagvkmgcWGLVIYAATGAICSAL 385
Cdd:COG2211  221 LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVL--------GLSAALVG---------LLLALYFLAALLGAPL 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953332 386 LQKYLDNYdlSVRVIYVLGTLGFSVGTAVMAMFP--NVYVAMVTISTMGIVSMSISYCPYALLGqyhDIKQYIHHSPGns 463
Cdd:COG2211  284 WPRLAKRF--GKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLA---DVVDYDEWKTG-- 356

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953332 464 KRGFGIDCAILSCQVYISQILVASALGGVVDAVG----------TVRVIPMVASVGSFLGFLTATFLVIYPNVSEEAKEE 533
Cdd:COG2211  357 RRREGLYFGIFTFAIKLGQALAGALAGLLLALFGyvagaaqspsALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAE 436
GPH_sucrose TIGR01301
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in ...
 306-526 2.27e-04

GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in plants, from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2) to sucrose sinks such as the tap root of the carrot.


Pssm-ID: 273545 [Multi-domain]  Cd Length: 477  Bit Score: 44.02  E-value: 2.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953332  306 LSMLKMPRELMRLCLChlLTWFSVIAEAVFYTDFMGQVIFEGDPKAPsnstawQAYNAGVKMGCWGLVIYAATGAICSAL 385
Cdd:TIGR01301 253 FKYLPRPVWILLLVTC--LNWIAWFPFILFDTDWMGREVYGGSVNQG------AKYDDGVRAGAFGLMLNSVVLGITSIG 324

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953332  386 LQKYLDNYDLSVR---VIYVLGTLGFSVGTAVMAMFPN-----------------VYVAMVTISTMGIvSMSISYC-PYA 444
Cdd:TIGR01301 325 MEKLCRGWGAGKRlwgIVNIILAICLAATVLVTYVAKNsryydgdgeslppptgiKASALIVFAILGI-PLAITYSiPFA 403

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953332  445 LLGQYHDikqyihhspgNSKRGFGIDCAILSCQVYISQILVaSALGGVVDAVGTVRVIP--MVASVGSFLGFLTATFLVI 522
Cdd:TIGR01301 404 LASIRSS----------NLGAGQGLSMGVLNLAIVIPQIIV-SLGSGPWDQLFGGGNLPafVVGAVAAFVSGLLALILLP 472


                  ....
gi 767953332  523 YPNV 526
Cdd:TIGR01301 473 RPRV 476
 
Name Accession Description Interval E-value
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 304-516 1.72e-55

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 194.00  E-value: 1.72e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953332 304 LWLSMLKMPRELMRLCLCHLLTWFSVIAEAVFYTDFMGQVIFEGdpkapsNSTAWQAYNAGVKMGCWGLVIYAATGAICS 383
Cdd:cd17313  225 LLKLLKIMPRSLLRLLLVIFFWWIAFFPFELFFTDYMGEEVYHG------TSAASSHYGAGVRMGAWGLLIFSLAFLIFS 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953332 384 ALLQKYLDNYdlSVRVIYVLGTLGFSVGTAVMAMFPNVYVAMVTISTMGIVSMSISYCPYALLGQYHDikqyihhspgNS 463
Cdd:cd17313  299 LPIGKLGKKI--GRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHS----------ES 366

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767953332 464 KRGFGIDCAILSCQVYISQILVASALGGV--VDAVGTVRVIPMVASVGSFLGFLT 516
Cdd:cd17313  367 GRGQGTDTGLLNLAISLAQILVSLLAGPIidVKGYGTVFPVAAVASFLSLVGALF 421
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 1-77 6.35e-19

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 89.61  E-value: 6.35e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767953332   1 MALNIHAFSAGLGGAIGYVLGGLDWTQTFLGSWFRTQNQVLFFFAAIIFTVSVALHLFSIDEEQYSPQQERSAEEPG 77
Cdd:cd17313  141 KANGIINFMGGLGGVLGYLLGAILWDHNWFGFALGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSPEAGEHSENPS 217
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
306-533 6.05e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 49.13  E-value: 6.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953332 306 LSMLKMPRELMRLCLCHLLTWFSVIAEAVFYTDFMGQVIfegdpkapSNSTAWQAynagvkmgcWGLVIYAATGAICSAL 385
Cdd:COG2211  221 LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVL--------GLSAALVG---------LLLALYFLAALLGAPL 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953332 386 LQKYLDNYdlSVRVIYVLGTLGFSVGTAVMAMFP--NVYVAMVTISTMGIVSMSISYCPYALLGqyhDIKQYIHHSPGns 463
Cdd:COG2211  284 WPRLAKRF--GKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLA---DVVDYDEWKTG-- 356

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953332 464 KRGFGIDCAILSCQVYISQILVASALGGVVDAVG----------TVRVIPMVASVGSFLGFLTATFLVIYPNVSEEAKEE 533
Cdd:COG2211  357 RRREGLYFGIFTFAIKLGQALAGALAGLLLALFGyvagaaqspsALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAE 436
GPH_sucrose TIGR01301
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in ...
 306-526 2.27e-04

GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in plants, from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2) to sucrose sinks such as the tap root of the carrot.


Pssm-ID: 273545 [Multi-domain]  Cd Length: 477  Bit Score: 44.02  E-value: 2.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953332  306 LSMLKMPRELMRLCLChlLTWFSVIAEAVFYTDFMGQVIFEGDPKAPsnstawQAYNAGVKMGCWGLVIYAATGAICSAL 385
Cdd:TIGR01301 253 FKYLPRPVWILLLVTC--LNWIAWFPFILFDTDWMGREVYGGSVNQG------AKYDDGVRAGAFGLMLNSVVLGITSIG 324

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953332  386 LQKYLDNYDLSVR---VIYVLGTLGFSVGTAVMAMFPN-----------------VYVAMVTISTMGIvSMSISYC-PYA 444
Cdd:TIGR01301 325 MEKLCRGWGAGKRlwgIVNIILAICLAATVLVTYVAKNsryydgdgeslppptgiKASALIVFAILGI-PLAITYSiPFA 403

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953332  445 LLGQYHDikqyihhspgNSKRGFGIDCAILSCQVYISQILVaSALGGVVDAVGTVRVIP--MVASVGSFLGFLTATFLVI 522
Cdd:TIGR01301 404 LASIRSS----------NLGAGQGLSMGVLNLAIVIPQIIV-SLGSGPWDQLFGGGNLPafVVGAVAAFVSGLLALILLP 472


                  ....
gi 767953332  523 YPNV 526
Cdd:TIGR01301 473 RPRV 476
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 318-543 5.41e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 42.80  E-value: 5.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953332 318 LCLCHLLTWFSVIAEAVFYTDFMGQVIFegdpkapsnSTAWQAYNAGVKMGcwglvIYAATGAICSALLQKYldnydlSV 397
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGL---------SASQLGLLFALFSL-----GYALLQPLAGLLADRF------GR 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953332 398 RVIYVLGTLGFSVGTAVMAMFPNVYVAMVTISTMGIVSMSISYCPYALLGQYHDIKQyihhspgnskrgFGIDCAILSCQ 477
Cdd:cd06174   61 RPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERE------------RGRALGLLQAF 128

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767953332 478 VYISQILVASALGGVVDAVG-TVRVIPMVASVGSFLGFLTATFLVIYPNVSEEAKEEQKGLSSPLAG 543
Cdd:cd06174  129 GSVGGILGPLLGGILASSLGfGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKL 195
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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