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Conserved domains on  [gi|767954396|ref|XP_011515978|]
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cyclin-dependent kinase inhibitor 2A isoform X2 [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
16-148 5.44e-19

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 81.54  E-value: 5.44e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954396  16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQV-MMMGSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTL 94
Cdd:COG0666  124 LHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLaAANGNLEIVKLLLEAGADVNARDNDGET-PLHLAAENGHLEIV 202

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767954396  95 VVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLRAAAGGTRGSNHARIDAA 148
Cdd:COG0666  203 KLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTAL 256
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
16-148 5.44e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 81.54  E-value: 5.44e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954396  16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQV-MMMGSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTL 94
Cdd:COG0666  124 LHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLaAANGNLEIVKLLLEAGADVNARDNDGET-PLHLAAENGHLEIV 202

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767954396  95 VVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLRAAAGGTRGSNHARIDAA 148
Cdd:COG0666  203 KLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTAL 256
PHA03095 PHA03095
ankyrin-like protein; Provisional
 24-116 1.06e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 47.33  E-value: 1.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954396  24 RVEEVRALLEAGALPNAPNSYGRRPIQVMMMGS--ARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTLVV--LHR 99
Cdd:PHA03095  62 VKDIVRLLLEAGADVNAPERCGFTPLHLYLYNAttLDVIKLLIKAGADVNAKDKVGRT-PLHVYLSGFNINPKVIrlLLR 140

                         90
                 ....*....|....*..
gi 767954396 100 AGARLDVRDAWGRLPVD 116
Cdd:PHA03095 141 KGADVNALDLYGMTPLA 157
Ank_2 pfam12796
Ankyrin repeats (3 copies);
55-130 1.06e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 42.03  E-value: 1.06e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767954396   55 GSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTLVVLHrAGARLDVRDAwGRLPVDLAEELGHRDVARYL 130
Cdd:pfam12796   8 GNLELVKLLLENGADANLQDKNGRT-ALHLAAKNGHLEIVKLLL-EHADVNLKDN-GRTALHYAARSGHLEIVKLL 80
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
16-148 5.44e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 81.54  E-value: 5.44e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954396  16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQV-MMMGSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTL 94
Cdd:COG0666  124 LHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLaAANGNLEIVKLLLEAGADVNARDNDGET-PLHLAAENGHLEIV 202

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767954396  95 VVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLRAAAGGTRGSNHARIDAA 148
Cdd:COG0666  203 KLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTAL 256
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
16-148 4.52e-15

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 70.75  E-value: 4.52e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954396  16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRP-IQVMMMGSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTL 94
Cdd:COG0666  157 LHLAAANGNLEIVKLLLEAGADVNARDNDGETPlHLAAENGHLEIVKLLLEAGADVNAKDNDGKT-ALDLAAENGNLEIV 235

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767954396  95 VVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLRAAAGGTRGSNHARIDAA 148
Cdd:COG0666  236 KLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
16-130 7.98e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 59.20  E-value: 7.98e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954396  16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRP-IQVMMMGSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTL 94
Cdd:COG0666   58 LLAAALAGDLLVALLLLAAGADINAKDDGGNTLlHAAARNGDLEIVKLLLEAGADVNARDKDGET-PLHLAAYNGNLEIV 136

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 767954396  95 VVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130
Cdd:COG0666  137 KLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLL 172
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
16-133 1.88e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 49.57  E-value: 1.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954396  16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLV 95
Cdd:COG0666   25 LLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVK 104

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767954396  96 VLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLRAA 133
Cdd:COG0666  105 LLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEA 142
PHA03095 PHA03095
ankyrin-like protein; Provisional
 24-116 1.06e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 47.33  E-value: 1.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954396  24 RVEEVRALLEAGALPNAPNSYGRRPIQVMMMGS--ARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTLVV--LHR 99
Cdd:PHA03095  62 VKDIVRLLLEAGADVNAPERCGFTPLHLYLYNAttLDVIKLLIKAGADVNAKDKVGRT-PLHVYLSGFNINPKVIrlLLR 140

                         90
                 ....*....|....*..
gi 767954396 100 AGARLDVRDAWGRLPVD 116
Cdd:PHA03095 141 KGADVNALDLYGMTPLA 157
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 50-130 4.09e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 45.66  E-value: 4.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954396  50 QVMMMGSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARY 129
Cdd:PTZ00322  88 QLAASGDAVGARILLTGGADPNCRDYDGRT-PLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQL 166


                 .
gi 767954396 130 L 130
Cdd:PTZ00322 167 L 167
Ank_2 pfam12796
Ankyrin repeats (3 copies);
55-130 1.06e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 42.03  E-value: 1.06e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767954396   55 GSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTLVVLHrAGARLDVRDAwGRLPVDLAEELGHRDVARYL 130
Cdd:pfam12796   8 GNLELVKLLLENGADANLQDKNGRT-ALHLAAKNGHLEIVKLLL-EHADVNLKDN-GRTALHYAARSGHLEIVKLL 80
Ank_2 pfam12796
Ankyrin repeats (3 copies);
16-108 1.74e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 41.25  E-value: 1.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954396   16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQV-MMMGSARVAELLLLHGAEPNCADPATltrPVHDAAREGFLDTL 94
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLaAKNGHLEIVKLLLEHADVNLKDNGRT---ALHYAARSGHLEIV 77

                          90
                  ....*....|....
gi 767954396   95 VVLHRAGARLDVRD 108
Cdd:pfam12796  78 KLLLEKGADINVKD 91
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 28-118 6.59e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 42.36  E-value: 6.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954396  28 VRALLEAGALPNAPNSYGRRPIQVMMMGSARVAEL--LLLHGAEPNCADPATLTrPVHDAAR-EGFLDTLVVLHRAGARL 104
Cdd:PHA02876 290 VPKLLERGADVNAKNIKGETPLYLMAKNGYDTENIrtLIMLGADVNAADRLYIT-PLHQASTlDRNKDIVITLLELGANV 368

                         90
                 ....*....|....
gi 767954396 105 DVRDAWGRLPVDLA 118
Cdd:PHA02876 369 NARDYCDKTPIHYA 382
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 16-99 7.71e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.19  E-value: 7.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954396  16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVM-MMGSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTL 94
Cdd:PTZ00322  86 LCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIAcANGHVQVVRVLLEFGADPTLLDKDGKT-PLELAEENGFREVV 164


                 ....*
gi 767954396  95 VVLHR 99
Cdd:PTZ00322 165 QLLSR 169
Ank_4 pfam13637
Ankyrin repeats (many copies);
16-64 1.21e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.02  E-value: 1.21e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767954396   16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQ-VMMMGSARVAELLL 64
Cdd:pfam13637   5 LHAAAASGHLELLRLLLEKGADINAVDGNGETALHfAASNGNVEVLKLLL 54
PHA03095 PHA03095
ankyrin-like protein; Provisional
 18-130 1.40e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 41.16  E-value: 1.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954396  18 TAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGS----ARVAELLLLHGAEPNCADPATLTrPVH----DAAREG 89
Cdd:PHA03095  20 LNASNVTVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSsekvKDIVRLLLEAGADVNAPERCGFT-PLHlylyNATTLD 98

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 767954396  90 FLDTLVvlhRAGARLDVRDAWGRLP--VDLAEELGHRDVARYL 130
Cdd:PHA03095  99 VIKLLI---KAGADVNAKDKVGRTPlhVYLSGFNINPKVIRLL 138
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 58-118 1.42e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 41.02  E-value: 1.42e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767954396  58 RVAELLLLHGAEPNCADpATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLA 118
Cdd:PHA02878 182 RLTELLLSYGANVNIPD-KTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHIS 241
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 4-150 1.86e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 41.01  E-value: 1.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954396   4 AAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMM-GSARVAELLLLHGAEPNCADpatltrpV 82
Cdd:PLN03192 614 ASISDPHAAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAeDHVDMVRLLIMNGADVDKAN-------T 686

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767954396  83 HDAAREGFLDTLVVLHRAGARLDVRDAwgrLPVDLaEELGHRDVARYLRAAAGGTRGSNHARIDAAEG 150
Cdd:PLN03192 687 DDDFSPTELRELLQKRELGHSITIVDS---VPADE-PDLGRDGGSRPGRLQGTSSDNQCRPRVSIYKG 750
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 49-130 6.09e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 39.47  E-value: 6.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954396  49 IQVMMMGSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVAR 128
Cdd:PLN03192 530 LTVASTGNAALLEELLKAKLDPDIGDSKGRT-PLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFR 608


                 ..
gi 767954396 129 YL 130
Cdd:PLN03192 609 IL 610
PHA03095 PHA03095
ankyrin-like protein; Provisional
 21-118 1.62e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 38.08  E-value: 1.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954396  21 ARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSARVAEL---LLLHGAEPNCADpATLTRPVHDAAreGFLDTLVVL 97
Cdd:PHA03095 198 FKPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLvlpLLIAGISINARN-RYGQTPLHYAA--VFNNPRACR 274

                         90       100
                 ....*....|....*....|...
gi 767954396  98 H--RAGARLDVRDAWGRLPVDLA 118
Cdd:PHA03095 275 RliALGADINAVSSDGNTPLSLM 297
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 26-130 2.63e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 37.25  E-value: 2.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954396  26 EEVRALLEAGALPNAPNSYGRRPIQ-VMMMGSARVAELLLLHGAEPNCADPATlTRPVHDAAREGFLDTLVVLHRAGARL 104
Cdd:PHA02874 105 DMIKTILDCGIDVNIKDAELKTFLHyAIKKGDLESIKMLFEYGADVNIEDDNG-CYPIHIAIKHNFFDIIKLLLEKGAYA 183

                         90       100
                 ....*....|....*....|....*.
gi 767954396 105 DVRDAWGRLPVDLAEELGHRDVARYL 130
Cdd:PHA02874 184 NVKDNNGESPLHNAAEYGDYACIKLL 209
PHA02946 PHA02946
ankyin-like protein; Provisional
 8-74 7.89e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 36.19  E-value: 7.89e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767954396   8 SMEPSADWL---ATAAARGRVEE-VRALLEAGALPNAPNSYGRRPIQVM-MMGSARVAELLLLHGAEPNCAD 74
Cdd:PHA02946  31 AIEPSGNYHilhAYCGIKGLDERfVEELLHRGYSPNETDDDGNYPLHIAsKINNNRIVAMLLTHGADPNACD 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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