|
Name |
Accession |
Description |
Interval |
E-value |
| CCDC144C |
pfam14915 |
CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ... |
327-617 |
9.26e-109 |
|
CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ankyrin repeat domain-containing protein 26-like 1 found in eukaryotes. Its function remains unknown, however, it is known to contain a coiled-coil domain which corresponds to this region. The ankyrin repeat which features in this protein is a common amino acid motif.
Pssm-ID: 464371 [Multi-domain] Cd Length: 304 Bit Score: 339.27 E-value: 9.26e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 327 NFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELE 406
Cdd:pfam14915 1 NCMLQDEIAMLRLEIDTIKNQNQEKEKKYLEDIEILKEKNDDLQKTLKLNEETLTKTVFQYNGQLNVLKAENTMLNSKLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 407 KEKHNKERLEAEVESLHSSLATAINEYNEIVERK-DLELVLWRADD--VSRHEKMGSNISQLTDKNELLTEQVHKARVKF 483
Cdd:pfam14915 81 NEKQNKERLETEVESYRSRLAAAIQDHEQSQTSKrDLELAFQRERDewLRLQDKMNFDVSNLRDENEILSQQLSKAESKA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 484 NTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDA 563
Cdd:pfam14915 161 NSLENELHRTRDALREKTLLLESVQRDLSQAQCQKKELEHMYQNEQDKVNKYIGKQESLEERLAQLQSENMLLRQQLEDA 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767954779 564 RKEGDNKE-IVINIHRDC--------LENGKED-LLEERNKELMKEYNYLKEKLLQCEKEKAER 617
Cdd:pfam14915 241 QNKADAKEkTVIDIQDQFqdivkklqAESEKQVlLLEERNKELINECNHLKERLYQYEKEKAER 304
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
39-268 |
9.02e-38 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 143.56 E-value: 9.02e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 39 HRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAI 118
Cdd:COG0666 58 LLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVK 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 119 VLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDN 198
Cdd:COG0666 138 LLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDN 217
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 199 FKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKNKMLKNHLRNDN 268
Cdd:COG0666 218 DGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLT 287
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
29-301 |
1.10e-34 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 134.31 E-value: 1.10e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 29 DIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKA 108
Cdd:COG0666 15 LLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 109 VHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLK 188
Cdd:COG0666 95 ARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLE 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 189 NQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKNKMLKNHLRNDN 268
Cdd:COG0666 175 AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLT 254
|
250 260 270
....*....|....*....|....*....|...
gi 767954779 269 QETAAMKPANLKKRKERAKAEHNLKVASEEKQE 301
Cdd:COG0666 255 ALLLAAAAGAALIVKLLLLALLLLAAALLDLLT 287
|
|
| DUF3496 |
pfam12001 |
Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. ... |
863-969 |
3.33e-33 |
|
Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 110 amino acids in length.
Pssm-ID: 463425 [Multi-domain] Cd Length: 109 Bit Score: 123.62 E-value: 3.33e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 863 LKKKELTLKDVECKFSKMKTAYEEV-TTELEEFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKLFTEKQRMKYFLSTLP 941
Cdd:pfam12001 1 RSQMELRIKDLESELSKMKTSQEDSnKIELEKYKQLYLEELKVRKSLSNKLNKTNERLAEVSTKLLVEKQQNRSLLSTLT 80
|
90 100
....*....|....*....|....*....
gi 767954779 942 TRPEPELPCVENLN-SIELNRKYIPKTAI 969
Cdd:pfam12001 81 TRPVLESPCVGNLNnSLVLNRNFIPRENL 109
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
38-236 |
3.50e-33 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 130.07 E-value: 3.50e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 38 IHRAAIKGDAAEVERCLTRRFrDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACA 117
Cdd:COG0666 91 LHAAARNGDLEIVKLLLEAGA-DVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIV 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 118 IVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVD 197
Cdd:COG0666 170 KLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKD 249
|
170 180 190
....*....|....*....|....*....|....*....
gi 767954779 198 NFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTA 236
Cdd:COG0666 250 KDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
38-204 |
2.17e-24 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 104.65 E-value: 2.17e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 38 IHRAAIKGDAAEVERCLTRRFrDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACA 117
Cdd:COG0666 124 LHLAAYNGNLEIVKLLLEAGA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIV 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 118 IVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVD 197
Cdd:COG0666 203 KLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAAL 282
|
....*..
gi 767954779 198 NFKRTAL 204
Cdd:COG0666 283 LDLLTLL 289
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
54-274 |
3.63e-23 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 100.80 E-value: 3.63e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 54 LTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIY 133
Cdd:COG0666 7 LLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 134 GNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLS 213
Cdd:COG0666 87 GNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNL 166
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767954779 214 SIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKNkmlKNHLRNDNQETAAM 274
Cdd:COG0666 167 EIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA---DVNAKDNDGKTALD 224
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
138-230 |
1.41e-15 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 72.84 E-value: 1.41e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 138 LHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNqANIHAVDNfKRTALILAVQHNLSSIVT 217
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHLEIVK 78
|
90
....*....|...
gi 767954779 218 LLLQQNIRISSQD 230
Cdd:pfam12796 79 LLLEKGADINVKD 91
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
72-164 |
7.60e-15 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 70.92 E-value: 7.60e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 72 LHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECgANPNIEDiYGNTALHYAVYNKGTSLAE 151
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78
|
90
....*....|...
gi 767954779 152 RLLSHHANIEALN 164
Cdd:pfam12796 79 LLLEKGADINVKD 91
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
60-275 |
1.63e-14 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 76.93 E-value: 1.63e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 60 DLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALH 139
Cdd:PHA02874 116 DVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLH 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 140 YAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQhMVEFLLkNQANIHAVDNFKRTALILAVQHNLS-SIVTL 218
Cdd:PHA02874 196 NAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRS-AIELLI-NNASINDQDIDGSTPLHHAINPPCDiDIIDI 273
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 219 LLQQNIRISSQDMFGQTAEDYAL-----CSDLRSI--------------RQQILEHK----NKMLKNHLRNDNQETAAMK 275
Cdd:PHA02874 274 LLYHKADISIKDNKGENPIDTAFkyinkDPVIKDIianavlikeadklkDSDFLEHIeikdNKEFSDFIKECNEEIEDMK 353
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
105-197 |
8.52e-14 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 67.83 E-value: 8.52e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 105 LMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLShHANIEALNkEGNTPLLFAINSRRQHMVE 184
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78
|
90
....*....|...
gi 767954779 185 FLLKNQANIHAVD 197
Cdd:pfam12796 79 LLLEKGADINVKD 91
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
74-236 |
6.44e-13 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 72.36 E-value: 6.44e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 74 LACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIV---LLECGANPNIEDIYGNTALHYAVYNKGT-SL 149
Cdd:PHA03095 20 LNASNVTVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDIvrlLLEAGADVNAPERCGFTPLHLYLYNATTlDV 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 150 AERLLSHHANIEALNKEGNTPLL-----FAINSRrqhMVEFLLKNQANIHAVDNFKRTAL-ILAVQHNLS-SIVTLLLQQ 222
Cdd:PHA03095 100 IKLLIKAGADVNAKDKVGRTPLHvylsgFNINPK---VIRLLLRKGADVNALDLYGMTPLaVLLKSRNANvELLRLLIDA 176
|
170
....*....|....
gi 767954779 223 NIRISSQDMFGQTA 236
Cdd:PHA03095 177 GADVYAVDDRFRSL 190
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
28-208 |
1.15e-12 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 71.45 E-value: 1.15e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 28 YDIRDWELRKIHRAAIKgdAAEVERCLTRRFRDLDARDR-KDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLM 106
Cdd:PHA02878 129 QTIDLVYIDKKSKDDII--EAEITKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLH 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 107 KAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAV-YNKGTSLAERLLSHHANIEALNK-EGNTPLLFAINSRRQhmVE 184
Cdd:PHA02878 207 HAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVgYCKDYDILKLLLEHGVDVNAKSYiLGLTALHSSIKSERK--LK 284
|
170 180
....*....|....*....|....
gi 767954779 185 FLLKNQANIHAVDNFKRTALILAV 208
Cdd:PHA02878 285 LLLEYGADINSLNSYKLTPLSSAV 308
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
38-131 |
4.37e-12 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 62.83 E-value: 4.37e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 38 IHRAAIKGDAAEVERcLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLhRRCQIDICDRlNRTPLMKAVHSQEEACA 117
Cdd:pfam12796 1 LHLAAKNGNLELVKL-LLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL-EHADVNLKDN-GRTALHYAARSGHLEIV 77
|
90
....*....|....
gi 767954779 118 IVLLECGANPNIED 131
Cdd:pfam12796 78 KLLLEKGADINVKD 91
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
119-229 |
1.65e-11 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 67.60 E-value: 1.65e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 119 VLLECGANPNIEDIY-GNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVD 197
Cdd:PHA02878 152 LLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARD 231
|
90 100 110
....*....|....*....|....*....|...
gi 767954779 198 NFKRTALILAVQHNLS-SIVTLLLQQNIRISSQ 229
Cdd:PHA02878 232 KCGNTPLHISVGYCKDyDILKLLLEHGVDVNAK 264
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
26-192 |
1.74e-11 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 67.32 E-value: 1.74e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 26 PGYDIRDWElRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPL 105
Cdd:PHA02875 61 PDVKYPDIE-SELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPL 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 106 MKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLL-FAINSRRQHMVE 184
Cdd:PHA02875 140 HLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALcYAIENNKIDIVR 219
|
....*...
gi 767954779 185 FLLKNQAN 192
Cdd:PHA02875 220 LFIKRGAD 227
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
30-223 |
2.64e-11 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 67.78 E-value: 2.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 30 IRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHG-RVQVVTLLLHRRCQIDICDRLNRTPLMKA 108
Cdd:PHA02876 269 IDDCKNTPLHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLYITPLHQA 348
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 109 -VHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHM-VEFL 186
Cdd:PHA02876 349 sTLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPYMsVKTL 428
|
170 180 190
....*....|....*....|....*....|....*..
gi 767954779 187 LKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQN 223
Cdd:PHA02876 429 IDRGANVNSKNKDLSTPLHYACKKNCKLDVIEMLLDN 465
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
45-255 |
1.42e-10 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 64.66 E-value: 1.42e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 45 GDAAEVERCLTRRFRDLDARDRKDRTVLHLacahgrvqvvtLLLHRrcqidicdrlNRTPLMKavhsqeeacaiVLLECG 124
Cdd:PHA03095 60 EKVKDIVRLLLEAGADVNAPERCGFTPLHL-----------YLYNA----------TTLDVIK-----------LLIKAG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 125 ANPNIEDIYGNTALHyaVYNKG----TSLAERLLSHHANIEALNKEGNTPLLFAINSRRQ--HMVEFLLKNQANIHAVDN 198
Cdd:PHA03095 108 ADVNAKDKVGRTPLH--VYLSGfninPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNAnvELLRLLIDAGADVYAVDD 185
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767954779 199 FKRTAL--ILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYA--LCSDLRSIRQQILEH 255
Cdd:PHA03095 186 RFRSLLhhHLQSFKPRARIVRELIRAGCDPAATDMLGNTPLHSMatGSSCKRSLVLPLLIA 246
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
42-199 |
2.73e-10 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 63.53 E-value: 2.73e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 42 AIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAH--GRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIV 119
Cdd:PHA03100 80 YNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLKIL 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 120 ------------------LLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQH 181
Cdd:PHA03100 160 kllidkgvdinaknrvnyLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKE 239
|
170
....*....|....*...
gi 767954779 182 MVEFLLKNQANIHAVDNF 199
Cdd:PHA03100 240 IFKLLLNNGPSIKTIIET 257
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
81-227 |
6.06e-10 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 62.38 E-value: 6.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 81 VQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIV--LLECGANPNIEDIYGNTALHYAV-YNKG-TSLAERLLSH 156
Cdd:PHA03100 86 KEIVKLLLEYGANVNAPDNNGITPLLYAISKKSNSYSIVeyLLDNGANVNIKNSDGENLLHLYLeSNKIdLKILKLLIDK 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 157 HANIEALNK----------------EGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLL 220
Cdd:PHA03100 166 GVDINAKNRvnyllsygvpinikdvYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLL 245
|
....*..
gi 767954779 221 QQNIRIS 227
Cdd:PHA03100 246 NNGPSIK 252
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
60-351 |
6.79e-10 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 62.38 E-value: 6.79e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 60 DLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAV---HSQEEACAIV--LLECGANPNIEDIYG 134
Cdd:PHA03100 27 LNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSnikYNLTDVKEIVklLLEYGANVNAPDNNG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 135 NTALHYAVYNKGTS--LAERLLSHHANIEALNKEGNTPLLFAI--NSRRQHMVEFLLKNQANIHAVDNFKR--------- 201
Cdd:PHA03100 107 ITPLLYAISKKSNSysIVEYLLDNGANVNIKNSDGENLLHLYLesNKIDLKILKLLIDKGVDINAKNRVNYllsygvpin 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 202 -------TALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYAlcsdlrsIRQQILEHKNKMLKNHlrndnqetaam 274
Cdd:PHA03100 187 ikdvygfTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIA-------ILNNNKEIFKLLLNNG----------- 248
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767954779 275 kpANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRK 351
Cdd:PHA03100 249 --PSIKTIIETLLYFKDKDLNTITKIKMLKKSIMYMFLLDPGFYKNRKLIENSKSLKDVINECEKEIERMKEIKLNK 323
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
69-222 |
1.24e-09 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 61.55 E-value: 1.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 69 RTVLHLACAHGRVQVVTLLLHRRCQI-DICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGT 147
Cdd:PHA02875 69 ESELHDAVEEGDVKAVEELLDLGKFAdDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDI 148
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767954779 148 SLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVD-NFKRTALILAVQHNLSSIVTLLLQQ 222
Cdd:PHA02875 149 KGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGkNGCVAALCYAIENNKIDIVRLFIKR 224
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
34-240 |
1.61e-09 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 62.00 E-value: 1.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 34 ELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDIC--DRL----------- 100
Cdd:PHA02876 144 EYMKLIKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIalDDLsvlecavdskn 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 101 ----------------NRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTS-LAERLLSHHANIEAL 163
Cdd:PHA02876 224 idtikaiidnrsninkNDLSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLSrLVPKLLERGADVNAK 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 164 NKEGNTPL-LFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILA--VQHNLSSIVTlLLQQNIRISSQDMFGQTAEDYA 240
Cdd:PHA02876 304 NIKGETPLyLMAKNGYDTENIRTLIMLGADVNAADRLYITPLHQAstLDRNKDIVIT-LLELGANVNARDYCDKTPIHYA 382
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
60-211 |
3.40e-09 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 60.42 E-value: 3.40e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 60 DLDARDRKDRTVLHlACAHG---RVQVVTLLLhrRCQIDICDR--LNRTPLMKAVHSQEEACAIV--LLECGANPNIEDI 132
Cdd:PHA03095 109 DVNAKDKVGRTPLH-VYLSGfniNPKVIRLLL--RKGADVNALdlYGMTPLAVLLKSRNANVELLrlLIDAGADVYAVDD 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 133 YGNTALHY-AVYNKG-TSLAERLLSHHANIEALNKEGNTPL-LFAINS--RRQHMVEFLLKNqANIHAVDNFKRTALILA 207
Cdd:PHA03095 186 RFRSLLHHhLQSFKPrARIVRELIRAGCDPAATDMLGNTPLhSMATGSscKRSLVLPLLIAG-ISINARNRYGQTPLHYA 264
|
....
gi 767954779 208 VQHN 211
Cdd:PHA03095 265 AVFN 268
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
60-198 |
3.59e-09 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 60.42 E-value: 3.59e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 60 DLDARDRKDRTVLHLAC--AHGRVQVVTLLLHRRCQIDICDRLNRTPL-MKAVHSQEEACAIV-LLECGANPNIEDIYGN 135
Cdd:PHA03095 179 DVYAVDDRFRSLLHHHLqsFKPRARIVRELIRAGCDPAATDMLGNTPLhSMATGSSCKRSLVLpLLIAGISINARNRYGQ 258
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767954779 136 TALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDN 198
Cdd:PHA03095 259 TPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAKNPSAETVAA 321
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
68-241 |
5.85e-09 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 59.59 E-value: 5.85e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 68 DRTVLHLACAHGrvQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGT 147
Cdd:PHA02874 93 DTSILPIPCIEK--DMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFF 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 148 SLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVtlLLQQNIRIS 227
Cdd:PHA02874 171 DIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAIE--LLINNASIN 248
|
170
....*....|....
gi 767954779 228 SQDMFGQTAEDYAL 241
Cdd:PHA02874 249 DQDIDGSTPLHHAI 262
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
80-230 |
3.01e-08 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 56.98 E-value: 3.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 80 RVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHY-----AVYNKGTSLAERLL 154
Cdd:PHA03100 14 KVKNIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYlsnikYNLTDVKEIVKLLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 155 SHHANIEALNKEGNTPLLFAINSRRQH--MVEFLLKNQANIHAVDNFKRTALILAVQHNL--SSIVTLLLQQNIRISSQD 230
Cdd:PHA03100 94 EYGANVNAPDNNGITPLLYAISKKSNSysIVEYLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLIDKGVDINAKN 173
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
87-220 |
8.10e-08 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 56.41 E-value: 8.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 87 LLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAeRLLSHHANIEALNKE 166
Cdd:PLN03192 544 LLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIF-RILYHFASISDPHAA 622
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 767954779 167 GNTpLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLL 220
Cdd:PLN03192 623 GDL-LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLI 675
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
41-209 |
1.52e-07 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 55.64 E-value: 1.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 41 AAIKGDAAEVERcLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVL 120
Cdd:PLN03192 532 VASTGNAALLEE-LLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRIL 610
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 121 LECGA--NPNIediyGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAV-- 196
Cdd:PLN03192 611 YHFASisDPHA----AGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKAnt 686
|
170
....*....|....
gi 767954779 197 -DNFKRTALILAVQ 209
Cdd:PLN03192 687 dDDFSPTELRELLQ 700
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
49-259 |
1.80e-07 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 55.02 E-value: 1.80e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 49 EVERCLTRRFRDldardrkdrTVLHLACAHGRVQVVTLLLhrRCQ-IDICDR--LNRTPLMKAV-HSQEEAcAIVLLECG 124
Cdd:cd22192 7 ELHLLQQKRISE---------SPLLLAAKENDVQAIKKLL--KCPsCDLFQRgaLGETALHVAAlYDNLEA-AVVLMEAA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 125 A----NPNIEDIY-GNTALHYAVYNKGTSLAERLLSHHA--------------NIEALNKEGNTPLLFAINSRRQHMVEF 185
Cdd:cd22192 75 PelvnEPMTSDLYqGETALHIAVVNQNLNLVRELIARGAdvvspratgtffrpGPKNLIYYGEHPLSFAACVGNEEIVRL 154
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767954779 186 LLKNQANIHAVDNFKRTALilavqHnlssivTLLLQQNIRISSQdMFgqtaeDYALCSDlRSIRQQILEH-KNKM 259
Cdd:cd22192 155 LIEHGADIRAQDSLGNTVL-----H------ILVLQPNKTFACQ-MY-----DLILSYD-KEDDLQPLDLvPNNQ 211
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
119-197 |
2.08e-07 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 54.90 E-value: 2.08e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767954779 119 VLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVD 197
Cdd:PTZ00322 100 ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFELG 178
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
353-898 |
2.39e-07 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 55.07 E-value: 2.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 353 KKYIQEIKSITEINANFEKSVRLNEKMITKTvarySQQLNDLKAENARLNSELEKEKHNKERLEAEVESLhsslaTAINE 432
Cdd:PRK03918 175 KRRIERLEKFIKRTENIEELIKEKEKELEEV----LREINEISSELPELREELEKLEKEVKELEELKEEI-----EELEK 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 433 YNEIVERKDLELVLWRADDVSRHEKMGSNISQLTDKNELLTEQVHKARvKFNTLKGKLRETRDALREKTLALGSVQLDLR 512
Cdd:PRK03918 246 ELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKAE-EYIKLSEFYEEYLDELREIEKRLSRLEEEIN 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 513 QAQHRIKEMKQMHPNGE---AKESQSIGKQNSLEERIRQ-QELENLLLERQLEDARKEGDNKEIVINihrdclengKEDL 588
Cdd:PRK03918 325 GIEERIKELEEKEERLEelkKKLKELEKRLEELEERHELyEEAKAKKEELERLKKRLTGLTPEKLEK---------ELEE 395
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 589 LEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQE----------ELVDHLKTFSISESPLEgTSHCHINLNETWTS 658
Cdd:PRK03918 396 LEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKakgkcpvcgrELTEEHRKELLEEYTAE-LKRIEKELKEIEEK 474
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 659 KKKLFQVEIQPEEKHEEFRKLFELISLlnytADQIRkknrELEEEATGYkkclemtinmlnafanedfschgdlNTDQLK 738
Cdd:PRK03918 475 ERKLRKELRELEKVLKKESELIKLKEL----AEQLK----ELEEKLKKY-------------------------NLEELE 521
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 739 MDI-LFKKLKQKFNDLVAEKEAVSSECvnlakdnevlhqellsmrnvqEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELG 817
Cdd:PRK03918 522 KKAeEYEKLKEKLIKLKGEIKSLKKEL---------------------EKLEELKKKLAELEKKLDELEEELAELLKELE 580
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 818 KLQEYKSELDERAVQEIEKLEEIHLQ-KQAEYEKQLEQlnkdntASLKKKELTLKDVECKFSKMKTAYEEVTTELEEFKE 896
Cdd:PRK03918 581 ELGFESVEELEERLKELEPFYNEYLElKDAEKELEREE------KELKKLEEELDKAFEELAETEKRLEELRKELEELEK 654
|
..
gi 767954779 897 AF 898
Cdd:PRK03918 655 KY 656
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
120-174 |
2.89e-07 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 48.11 E-value: 2.89e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 767954779 120 LLECG-ANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFA 174
Cdd:pfam13857 1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
134-187 |
4.95e-07 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 47.27 E-value: 4.95e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 767954779 134 GNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLL 187
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
460-907 |
9.28e-07 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 53.15 E-value: 9.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 460 SNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQmhpngeaKESQSIGKQ 539
Cdd:TIGR02169 667 LFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQ-------EEEKLKERL 739
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 540 NSLEERIRQQELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKEYNYLKEkllqcekEKAEREV 619
Cdd:TIGR02169 740 EELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAELSKLEE-------EVSRIEA 812
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 620 IVREFQEELVDHLKTFSISESplegtshchinlnetwtSKKKLFQVEIQPEEKHEEFRKLFELISLlnytadQIRKKNRE 699
Cdd:TIGR02169 813 RLREIEQKLNRLTLEKEYLEK-----------------EIQELQEQRIDLKEQIKSIEKEIENLNG------KKEELEEE 869
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 700 LEEeatgykkclemtinmLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFNDLVAEKEavssecvnlaKDNEVLHQELL 779
Cdd:TIGR02169 870 LEE---------------LEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIE----------KKRKRLSELKA 924
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 780 SMRNVQEKCEKLEKDKKMLEEEVLNLkthmekdmVELGKLQEYKSELDERavqeIEKLEEIHLQKQAEYEKQLEQLNkdn 859
Cdd:TIGR02169 925 KLEALEEELSEIEDPKGEDEEIPEEE--------LSLEDVQAELQRVEEE----IRALEPVNMLAIQEYEEVLKRLD--- 989
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 767954779 860 taSLKKKELTLKdveckfsKMKTAYEEVTTELEEFK-EAFAGAVKANNS 907
Cdd:TIGR02169 990 --ELKEKRAKLE-------EERKAILERIEEYEKKKrEVFMEAFEAINE 1029
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
330-628 |
9.62e-07 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 53.14 E-value: 9.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 330 LKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKsVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEK 409
Cdd:TIGR02168 696 LEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLAR-LEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAE 774
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 410 HNKERLEAEVESLHSSLATAINEyneiverkdlelvlwraddvsrhekMGSNISQLTDknellteqvhkarvkfntLKGK 489
Cdd:TIGR02168 775 EELAEAEAEIEELEAQIEQLKEE-------------------------LKALREALDE------------------LRAE 811
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 490 LRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQqelenllLERQLEDARKEGDN 569
Cdd:TIGR02168 812 LTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEE-------LESELEALLNERAS 884
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767954779 570 KEIVINIHRDCLENGKEDL--LEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQEEL 628
Cdd:TIGR02168 885 LEEALALLRSELEELSEELreLESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERL 945
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
42-123 |
1.59e-06 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 52.21 E-value: 1.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 42 AIKGDAAEVeRCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLL 121
Cdd:PTZ00322 90 AASGDAVGA-RILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
|
..
gi 767954779 122 EC 123
Cdd:PTZ00322 169 RH 170
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
277-934 |
4.10e-06 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 50.83 E-value: 4.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 277 ANLKKRKERAKAE-HNLKVASEEKQERLQRSENKQPQDSQSYGkkkdamygnfMLKKDIAMLKEELYAIKNDsLRKEKKY 355
Cdd:TIGR02168 298 SRLEQQKQILRERlANLERQLEELEAQLEELESKLDELAEELA----------ELEEKLEELKEELESLEAE-LEELEAE 366
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 356 IQEIKSIteINANFEKSVRLNEKmitktVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAineyne 435
Cdd:TIGR02168 367 LEELESR--LEELEEQLETLRSK-----VAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEA------ 433
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 436 ivERKDLElvlwraddvsrhekmgsniSQLTDKNELLTEQVHkarvKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQ 515
Cdd:TIGR02168 434 --ELKELQ-------------------AELEELEEELEELQE----ELERLEEALEELREELEEAEQALDAAERELAQLQ 488
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 516 HRIKEMKQMHpngEAKESQSIGKQNSLEERIRQQELENLLLErQLEDARKEGDNKEIVinihrdcLENGKEDLLEERNKE 595
Cdd:TIGR02168 489 ARLDSLERLQ---ENLEGFSEGVKALLKNQSGLSGILGVLSE-LISVDEGYEAAIEAA-------LGGRLQAVVVENLNA 557
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 596 LMKEYNYLKEKLLQ-----------------CEKEKAEREVIVREFQEELVDHLKTFSISESPLEGTSHCHINLNETWTS 658
Cdd:TIGR02168 558 AKKAIAFLKQNELGrvtflpldsikgteiqgNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVLVVDDLDNALEL 637
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 659 KKKL-------------------------------FQVEIQPEEKHEEFRKLFELISLLNYTADQIRKKNRELEEEATGY 707
Cdd:TIGR02168 638 AKKLrpgyrivtldgdlvrpggvitggsaktnssiLERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQL 717
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 708 KKCLEmtinmlnafanedfschgDLNTDQLKMDILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRnvqEK 787
Cdd:TIGR02168 718 RKELE------------------ELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAE---EE 776
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 788 CEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDERAVQEIEKLEEiHLQKQAEYEKQLEQLNKdntaSLKKKE 867
Cdd:TIGR02168 777 LAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLES-LERRIAATERRLEDLEE----QIEELS 851
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767954779 868 LTLKDVECKFSKMKTAYEEVTTELEEFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKLFTEKQRMK 934
Cdd:TIGR02168 852 EDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELE 918
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
167-220 |
7.73e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 44.19 E-value: 7.73e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 767954779 167 GNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLL 220
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
69-121 |
9.14e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 43.80 E-value: 9.14e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 767954779 69 RTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLL 121
Cdd:pfam13637 2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
117-274 |
9.54e-06 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 48.80 E-value: 9.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 117 AIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAV 196
Cdd:COG0666 4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767954779 197 DNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKnkmLKNHLRNDNQETAAM 274
Cdd:COG0666 84 DDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAG---ADVNAQDNDGNTPLH 158
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
275-903 |
1.07e-05 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 49.75 E-value: 1.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 275 KPANLKKRKERAKAEHNLKVASEEKQ--ERLQRSENKQPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKE 352
Cdd:PTZ00121 1291 KADEAKKAEEKKKADEAKKKAEEAKKadEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAE 1370
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 353 KKYIQEIKSITEINANFEKSVRLNEkmITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINE 432
Cdd:PTZ00121 1371 KKKEEAKKKADAAKKKAEEKKKADE--AKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADE 1448
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 433 YNEIVERKDlelvlwRADDVSRHEKMGSNISQLTDKNELlTEQVHKARVKFNTLKGKLRETRDALREKTLALgsvqlDLR 512
Cdd:PTZ00121 1449 AKKKAEEAK------KAEEAKKKAEEAKKADEAKKKAEE-AKKADEAKKKAEEAKKKADEAKKAAEAKKKAD-----EAK 1516
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 513 QAQHRIK--EMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNKEIVINiHRDCLENGKEDLLE 590
Cdd:PTZ00121 1517 KAEEAKKadEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALR-KAEEAKKAEEARIE 1595
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 591 ERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQEelvdhlktfsisesplegtshchinlnetwtsKKKLFQVEIQPE 670
Cdd:PTZ00121 1596 EVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEE--------------------------------KKKVEQLKKKEA 1643
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 671 E---KHEEFRKLFELISLlnyTADQIRKKNRELEEEATGYKKclemtinmlnafANEDfschgdlntDQLKMDILFKKlk 747
Cdd:PTZ00121 1644 EekkKAEELKKAEEENKI---KAAEEAKKAEEDKKKAEEAKK------------AEED---------EKKAAEALKKE-- 1697
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 748 qkfndlvaEKEAVSSECVNLAKDNEVLHQELLSmRNVQEKCEKLEKDKKMLEEEvlnlkthmEKDMVELGKLQEYKSELD 827
Cdd:PTZ00121 1698 --------AEEAKKAEELKKKEAEEKKKAEELK-KAEEENKIKAEEAKKEAEED--------KKKAEEAKKDEEEKKKIA 1760
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767954779 828 ERAVQEIEKLEEIHLQKQAEYEkqlEQLNKDNTASLKKKELTLKDVECKFSKMKTAYEEVTTELEEFKEAFAGAVK 903
Cdd:PTZ00121 1761 HLKKEEEKKAEEIRKEKEAVIE---EELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSKEMEDSAIK 1833
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
42-255 |
1.09e-05 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 49.11 E-value: 1.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 42 AIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLL 121
Cdd:PHA02878 44 AVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYTLVAIKDAFNNRNVEIFKIILTN 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 122 ECGANPNIEDIYGNTALHYAVYNkgTSLAERLLSHHANIEALNKE-GNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFK 200
Cdd:PHA02878 124 RYKNIQTIDLVYIDKKSKDDIIE--AEITKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPDKTN 201
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 767954779 201 RTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLR-SIRQQILEH 255
Cdd:PHA02878 202 NSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYCKDyDILKLLLEH 257
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
330-837 |
1.48e-05 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 48.91 E-value: 1.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 330 LKKDIAMLKEELYAIKnDSLRKEKKYIQE----IKSITEINANFEKSVRLNEKM---------ITKTVARYSQQLNDLKA 396
Cdd:PRK03918 250 LEGSKRKLEEKIRELE-ERIEELKKEIEEleekVKELKELKEKAEEYIKLSEFYeeyldelreIEKRLSRLEEEINGIEE 328
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 397 ENARLNSELEKEKHNKERLEaEVESLHSSLATAINEYNEIVERKDLELVLWRADDVSRHEKMGSNISQLTDKNELLTEQV 476
Cdd:PRK03918 329 RIKELEEKEERLEELKKKLK-ELEKRLEELEERHELYEEAKAKKEELERLKKRLTGLTPEKLEKELEELEKAKEEIEEEI 407
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 477 HKARVKFNTLKGKLRETRDA--------------------------LREKTLALGSVQLDLRQAQHRIKEMKQMHPN--G 528
Cdd:PRK03918 408 SKITARIGELKKEIKELKKAieelkkakgkcpvcgrelteehrkelLEEYTAELKRIEKELKEIEEKERKLRKELREleK 487
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 529 EAKESQSIGKQNSLEERIR--QQELENLLLERQLEDARKEGDNKEIVINIHRDcLENGKEDLleERNKELMKEYNYLKEK 606
Cdd:PRK03918 488 VLKKESELIKLKELAEQLKelEEKLKKYNLEELEKKAEEYEKLKEKLIKLKGE-IKSLKKEL--EKLEELKKKLAELEKK 564
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 607 LLQCEKEKAEREVIVREFQEELVDHLktfsisESPLEGTSHCHINLNETWTSKKKLFQVEIQPEEKHEEFRKLFELISLL 686
Cdd:PRK03918 565 LDELEEELAELLKELEELGFESVEEL------EERLKELEPFYNEYLELKDAEKELEREEKELKKLEEELDKAFEELAET 638
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 687 NYTADQIRKKNRELEEEatgykkclemtinmlnaFANEDFSchgdlntdqlKMDILFKKLKQKFNDLVAEKEAVSSECVN 766
Cdd:PRK03918 639 EKRLEELRKELEELEKK-----------------YSEEEYE----------ELREEYLELSRELAGLRAELEELEKRREE 691
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767954779 767 LAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVlnlkthmekdmvelGKLQEYKSELDERAVQEIEKL 837
Cdd:PRK03918 692 IKKTLEKLKEELEEREKAKKELEKLEKALERVEELR--------------EKVKKYKALLKERALSKVGEI 748
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
34-88 |
1.55e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 43.03 E-value: 1.55e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 767954779 34 ELRKIHRAAIKGDAAEVERCLTRRFrDLDARDRKDRTVLHLACAHGRVQVVTLLL 88
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGA-DINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
153-207 |
2.11e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 42.72 E-value: 2.11e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 767954779 153 LLSH-HANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILA 207
Cdd:pfam13857 1 LLEHgPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| SMC_N |
pfam02463 |
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ... |
277-931 |
8.54e-05 |
|
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.
Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 46.50 E-value: 8.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 277 ANLKKRKERA----------KAEHNLKVASEEKQERLQRSENKQPQDSQSYGKKKDAMYGNFMLK---KDIAMLKEELYA 343
Cdd:pfam02463 165 SRLKRKKKEAlkklieetenLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLdylKLNEERIDLLQE 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 344 IKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESLH 423
Cdd:pfam02463 245 LLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKK 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 424 SSLATAINEYNEIVERKDLELVLWRADdvsrhEKMGSNISQLTDKNELLTEQVHKARVKFnTLKGKLRETRDALREKTLA 503
Cdd:pfam02463 325 KAEKELKKEKEEIEELEKELKELEIKR-----EAEEEEEEELEKLQEKLEQLEEELLAKK-KLESERLSSAAKLKEEELE 398
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 504 LGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNKEivinihrdclEN 583
Cdd:pfam02463 399 LKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELE----------LK 468
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 584 GKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVIVRE---FQEELVDHLKTFSISESPLEGTSHCHINLNETWTSKK 660
Cdd:pfam02463 469 KSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGlkvLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTA 548
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 661 KLFQVEIQPEEKHEEFRKLFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANEdFSCHGDLNTDQLKMD 740
Cdd:pfam02463 549 VIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKAT-LEADEDDKRAKVVEG 627
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 741 ILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHqeLLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQ 820
Cdd:pfam02463 628 ILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKS--EVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKE 705
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 821 EYKSELDERAVQEIEKLEEIHLQ--------KQAEYEKQLEQLNKDNTASLKKKELTLKDVECKFSKMKTAYEEVTTELE 892
Cdd:pfam02463 706 QREKEELKKLKLEAEELLADRVQeaqdkineELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEK 785
|
650 660 670
....*....|....*....|....*....|....*....
gi 767954779 893 EFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKLFTEKQ 931
Cdd:pfam02463 786 LKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLI 824
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
60-175 |
8.58e-05 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 46.60 E-value: 8.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 60 DLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAI-VLLECGANPNIEDIYGNTAL 138
Cdd:PHA02876 367 NVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPYMSVkTLIDRGANVNSKNKDLSTPL 446
|
90 100 110
....*....|....*....|....*....|....*...
gi 767954779 139 HYAVYNK-GTSLAERLLSHHANIEALNKEGNTPLLFAI 175
Cdd:PHA02876 447 HYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIAL 484
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
54-105 |
8.94e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 41.18 E-value: 8.94e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 767954779 54 LTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPL 105
Cdd:pfam13857 2 LEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
101-154 |
9.38e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 41.11 E-value: 9.38e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 767954779 101 NRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLL 154
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| DUF3584 |
pfam12128 |
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ... |
221-672 |
1.11e-04 |
|
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.
Pssm-ID: 432349 [Multi-domain] Cd Length: 1191 Bit Score: 46.37 E-value: 1.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 221 QQNIRISSQDMFGQTAEDYALcsdlrsirQQILEHKNKMLKNHLRNDNQETAAMKPANLKkrkeRAKAEHNLKVAS--EE 298
Cdd:pfam12128 213 PPKSRLNRQQVEHWIRDIQAI--------AGIMKIRPEFTKLQQEFNTLESAELRLSHLH----FGYKSDETLIASrqEE 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 299 KQERLQRSENKQPQDSQSYGKKKDAMYGN-FMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNE 377
Cdd:pfam12128 281 RQETSAELNQLLRTLDDQWKEKRDELNGElSAADAAVAKDRSELEALEDQHGAFLDADIETAAADQEQLPSWQSELENLE 360
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 378 KMI-----------TKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVES--------LHSSLATAINEYNEIVE 438
Cdd:pfam12128 361 ERLkaltgkhqdvtAKYNRRRSKIKEQNNRDIAGIKDKLAKIREARDRQLAVAEDdlqaleseLREQLEAGKLEFNEEEY 440
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 439 RKDL----------------ELVLWRADDVSRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTL 502
Cdd:pfam12128 441 RLKSrlgelklrlnqatatpELLLQLENFDERIERAREEQEAANAEVERLQSELRQARKRRDQASEALRQASRRLEERQS 520
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 503 ALGSVQLDLRQAQHRIKEMKqmhpNGEAKE-SQSIGKQNSLEERIRQQelenllLERQLEDARKEGDNKEIVINIHRDCL 581
Cdd:pfam12128 521 ALDELELQLFPQAGTLLHFL----RKEAPDwEQSIGKVISPELLHRTD------LDPEVWDGSVGGELNLYGVKLDLKRI 590
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 582 ENGK----EDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQEELVDHLKTFSISESPLEGTSHCHINL----N 653
Cdd:pfam12128 591 DVPEwaasEEELRERLDKAEEALQSAREKQAAAEEQLVQANGELEKASREETFARTALKNARLDLRRLFDEKQSEkdkkN 670
|
490
....*....|....*....
gi 767954779 654 ETWTSKKKLFQVEIQPEEK 672
Cdd:pfam12128 671 KALAERKDSANERLNSLEA 689
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
133-165 |
1.23e-04 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 39.97 E-value: 1.23e-04
10 20 30
....*....|....*....|....*....|....
gi 767954779 133 YGNTALHYAVYNKG-TSLAERLLSHHANIEALNK 165
Cdd:pfam00023 1 DGNTPLHLAAGRRGnLEIVKLLLSKGADVNARDK 34
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
279-901 |
1.25e-04 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 46.20 E-value: 1.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 279 LKKRKERAKAE-HNLKVASEEKQERLQRSENKQPQDSQSYGKKKDAMYgnfMLKKDIAMLKEELYAIKNDSLRKEKKyiq 357
Cdd:TIGR02168 230 LVLRLEELREElEELQEELKEAEEELEELTAELQELEEKLEELRLEVS---ELEEEIEELQKELYALANEISRLEQQ--- 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 358 eiksITEINANFEKSVRlNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESLHS---SLATAINEYN 434
Cdd:TIGR02168 304 ----KQILRERLANLER-QLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAeleELESRLEELE 378
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 435 EIVE---RKDLELVLWRADDVSRHEKMGSNISQLTDKNELLTEQVHKA-----RVKFNTLKGKLRETRDALREKTLALGS 506
Cdd:TIGR02168 379 EQLEtlrSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELlkkleEAELKELQAELEELEEELEELQEELER 458
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 507 VQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNKEIVINI------HRDC 580
Cdd:TIGR02168 459 LEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELisvdegYEAA 538
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 581 LEN----GKEDLLEERNKELMKEYNYLKEKLLQ-----------------CEKEKAEREVIVREFQEELVDHLKTFSISE 639
Cdd:TIGR02168 539 IEAalggRLQAVVVENLNAAKKAIAFLKQNELGrvtflpldsikgteiqgNDREILKNIEGFLGVAKDLVKFDPKLRKAL 618
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 640 SPLEGTSHCHINLNETWTSKKKL-------------------------------FQVEIQPEEKHEEFRKLFELISLLNY 688
Cdd:TIGR02168 619 SYLLGGVLVVDDLDNALELAKKLrpgyrivtldgdlvrpggvitggsaktnssiLERRREIEELEEKIEELEEKIAELEK 698
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 689 TADQIRKKNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFNDLVAEKEAVSSECVNLA 768
Cdd:TIGR02168 699 ALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELA 778
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 769 KDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTH----------MEKDMVELGKLQEYKSELDERAVQEIEKLE 838
Cdd:TIGR02168 779 EAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEaanlrerlesLERRIAATERRLEDLEEQIEELSEDIESLA 858
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767954779 839 EIHLQKQAEYEKQLEQLNK---------DNTASLK----KKELTLKDVECKFSKMKTAYEEVTTELEEFKEAFAGA 901
Cdd:TIGR02168 859 AEIEELEELIEELESELEAllnerasleEALALLRseleELSEELRELESKRSELRRELEELREKLAQLELRLEGL 934
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
432-633 |
1.45e-04 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 45.70 E-value: 1.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 432 EYNEIVERKDLELVLWRADDVSRhekmgsNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQLDL 511
Cdd:COG1196 217 ELKEELKELEAELLLLKLRELEA------ELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEE 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 512 RQAQHRIKEMkqmhpngEAKESQSIGKQNSLEERIRQQELENLLLERQLEDARKEgdnkeivinihrdclengkEDLLEE 591
Cdd:COG1196 291 YELLAELARL-------EQDIARLEERRRELEERLEELEEELAELEEELEELEEE-------------------LEELEE 344
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 767954779 592 RNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQEELVDHLK 633
Cdd:COG1196 345 ELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAE 386
|
|
| Mplasa_alph_rch |
TIGR04523 |
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ... |
337-918 |
1.51e-04 |
|
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.
Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 45.78 E-value: 1.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 337 LKEELYAIKNDSLRKEKK-------YIQEIKSITEINANFEKsVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEK 409
Cdd:TIGR04523 38 LEKKLKTIKNELKNKEKElknldknLNKDEEKINNSNNKIKI-LEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDK 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 410 HNKERLEAEVESL---------------------HSSLATAINEYNEIVERK-DLELVLWRADD---------------V 452
Cdd:TIGR04523 117 EQKNKLEVELNKLekqkkenkknidkflteikkkEKELEKLNNKYNDLKKQKeELENELNLLEKeklniqknidkiknkL 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 453 SRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKE 532
Cdd:TIGR04523 197 LKLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKEL 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 533 SQSIGKQNSLEERIRQqelenllLERQLEDarkegdnkeivinihrdcLENGKEdllEERNKELMKEYNYLKEKLLQCEK 612
Cdd:TIGR04523 277 EQNNKKIKELEKQLNQ-------LKSEISD------------------LNNQKE---QDWNKELKSELKNQEKKLEEIQN 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 613 EKAEREVIVREFQEELVDHLKTFSISESPlegTSHCHINLNEtwtSKKKLFQVEIQPEEKHEEFRKLFELISLLNYTADQ 692
Cdd:TIGR04523 329 QISQNNKIISQLNEQISQLKKELTNSESE---NSEKQRELEE---KQNEIEKLKKENQSYKQEIKNLESQINDLESKIQN 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 693 IRKKNRELEEEATGYKK---CLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFNDLVAEKEAVSSECVNLAK 769
Cdd:TIGR04523 403 QEKLNQQKDEQIKKLQQekeLLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQ 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 770 DNEVLHQELLSMRNvqeKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDERAVQEIEKLEEI-------HL 842
Cdd:TIGR04523 483 NLEQKQKELKSKEK---ELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKDdfelkkeNL 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 843 QKQA-EYEKQLEQLNKDNTASLKK---KELTLKDVECKFSKMKTAYEEVTTELEEFKEAFAGAVKANNSMSKKLMKSDKK 918
Cdd:TIGR04523 560 EKEIdEKNKEIEELKQTQKSLKKKqeeKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSK 639
|
|
| CCDC158 |
pfam15921 |
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ... |
264-832 |
1.55e-04 |
|
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.
Pssm-ID: 464943 [Multi-domain] Cd Length: 1112 Bit Score: 45.88 E-value: 1.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 264 LRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQDS----QSYGKKKDAMYGNFM--LKKDIAML 337
Cdd:pfam15921 250 LKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQleiiQEQARNQNSMYMRQLsdLESTVSQL 329
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 338 KEELYAIKndslRKEKKYIQEI-KSITEINANFEKSvRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKERL- 415
Cdd:pfam15921 330 RSELREAK----RMYEDKIEELeKQLVLANSELTEA-RTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLw 404
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 416 --------------------EAEVESLHSSLATAINEYNEIVERKdLELVLWRADDVsrhEKMGSNISQLTDKNELLTEQ 475
Cdd:pfam15921 405 drdtgnsitidhlrrelddrNMEVQRLEALLKAMKSECQGQMERQ-MAAIQGKNESL---EKVSSLTAQLESTKEMLRKV 480
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 476 VHKARVKFNTLKGKLRETRD---ALREKTLALGS-----------VQLDLRQAQHRIKE---MKQMHPNGEAKESQSIGK 538
Cdd:pfam15921 481 VEELTAKKMTLESSERTVSDltaSLQEKERAIEAtnaeitklrsrVDLKLQELQHLKNEgdhLRNVQTECEALKLQMAEK 560
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 539 QNSLEerIRQQELENLLlerQL--EDARKEGdnkeiVINIHRDCLEngKEdlLEERNKELmKEYNYLKEKllqceKEKAE 616
Cdd:pfam15921 561 DKVIE--ILRQQIENMT---QLvgQHGRTAG-----AMQVEKAQLE--KE--INDRRLEL-QEFKILKDK-----KDAKI 620
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 617 REVIVREFQEELvDHLKTFSISESPLEGTSHCHIN----LNETWTSKKKLFQVEIQPEEKHEEFR-KLFELISLLNYTAD 691
Cdd:pfam15921 621 RELEARVSDLEL-EKVKLVNAGSERLRAVKDIKQErdqlLNEVKTSRNELNSLSEDYEVLKRNFRnKSEEMETTTNKLKM 699
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 692 QIRKKNRELEEEATGYKK-------CLEMTINMLNAFANEdfscHGDLNTDQLKMDILFKKLKQKFND---LVAEKEAVS 761
Cdd:pfam15921 700 QLKSAQSELEQTRNTLKSmegsdghAMKVAMGMQKQITAK----RGQIDALQSKIQFLEEAMTNANKEkhfLKEEKNKLS 775
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767954779 762 SECVNLAKDNEVLHQELlsmrnvqekcEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDERAVQ 832
Cdd:pfam15921 776 QELSTVATEKNKMAGEL----------EVLRSQERRLKEKVANMEVALDKASLQFAECQDIIQRQEQESVR 836
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
330-912 |
1.62e-04 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 45.82 E-value: 1.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 330 LKKDIAMLKEELYAIKNDSLRKE--------KKYIQEIKSIT-EINANFEKSVRLNEKMitktvARYSQQLNDLKAENAR 400
Cdd:TIGR02168 218 LKAELRELELALLVLRLEELREEleelqeelKEAEEELEELTaELQELEEKLEELRLEV-----SELEEEIEELQKELYA 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 401 LNSELEKEKHNKERLEAEVESLHSSLAtAINEYNEIVERKDLELvlwrADDVSRHEKmgsNISQLTDKNELLTEQVHKAR 480
Cdd:TIGR02168 293 LANEISRLEQQKQILRERLANLERQLE-ELEAQLEELESKLDEL----AEELAELEE---KLEELKEELESLEAELEELE 364
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 481 VKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMkqmhpngEAKESQSIGKQNSLEERIRQQELENLLLERQL 560
Cdd:TIGR02168 365 AELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERL-------EARLERLEDRRERLQQEIEELLKKLEEAELKE 437
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 561 EDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQE------ELVDHLKT 634
Cdd:TIGR02168 438 LQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGfsegvkALLKNQSG 517
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 635 FS---------IS-----ESPLEGTshCHINLNETWTSKKKLFQVEIQPEEKHEEFRKLFELISLLNYTADQIRKKNREL 700
Cdd:TIGR02168 518 LSgilgvlselISvdegyEAAIEAA--LGGRLQAVVVENLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILK 595
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 701 EEE-ATGYKKCLEMTINMLNAFANEDFSchGDLNTDQLKMDI-LFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHqel 778
Cdd:TIGR02168 596 NIEgFLGVAKDLVKFDPKLRKALSYLLG--GVLVVDDLDNALeLAKKLRPGYRIVTLDGDLVRPGGVITGGSAKTNS--- 670
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 779 lSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELD------ERAVQEIEKLEEIHLQKQAEYEKQL 852
Cdd:TIGR02168 671 -SILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRkeleelSRQISALRKDLARLEAEVEQLEERI 749
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 853 EQLNKDNTASLKKKELTLKDVECKFSKMKTAyEEVTTELEEFKEAFAGAVKANNSMSKKL 912
Cdd:TIGR02168 750 AQLSKELTELEAEIEELEERLEEAEEELAEA-EAEIEELEAQIEQLKEELKALREALDEL 808
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
329-857 |
2.21e-04 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 45.44 E-value: 2.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 329 MLKKDIAMLKEELYA---IKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEKmitktVARYSQQLNDLKAENARLNSEL 405
Cdd:PRK03918 173 EIKRRIERLEKFIKRtenIEELIKEKEKELEEVLREINEISSELPELREELEK-----LEKEVKELEELKEEIEELEKEL 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 406 EKEKHNKERLEAEVESLHSSLATAINEYNEIVER-KDLELVLWRADDVSR-------HEKMGSNISQLTDKNELLTEQVH 477
Cdd:PRK03918 248 ESLEGSKRKLEEKIRELEERIEELKKEIEELEEKvKELKELKEKAEEYIKlsefyeeYLDELREIEKRLSRLEEEINGIE 327
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 478 KARVKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLE 557
Cdd:PRK03918 328 ERIKELEEKEERLEELKKKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLTGLTPEKLEKELEELEKAKEEIEEEI 407
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 558 RQLEDARKEGDNKEIVINIHRDCLENGK-------EDLLEERNKELMKEYnylKEKLLQCEKEKAEREVIVREFQEELVD 630
Cdd:PRK03918 408 SKITARIGELKKEIKELKKAIEELKKAKgkcpvcgRELTEEHRKELLEEY---TAELKRIEKELKEIEEKERKLRKELRE 484
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 631 hLKTFSISESPLEGTSHCHINLNETWTSKKKLFQVEIqpEEKHEEFRKLFEL-------ISLLNYTADQIRKKNRELEEE 703
Cdd:PRK03918 485 -LEKVLKKESELIKLKELAEQLKELEEKLKKYNLEEL--EKKAEEYEKLKEKliklkgeIKSLKKELEKLEELKKKLAEL 561
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 704 ATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKK---LKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLS 780
Cdd:PRK03918 562 EKKLDELEEELAELLKELEELGFESVEELEERLKELEPFYNEyleLKDAEKELEREEKELKKLEEELDKAFEELAETEKR 641
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 781 MRNVQEKCEKLEKdkKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDER---AVQEIEKLEEiHLQKQAEYEKQLEQLNK 857
Cdd:PRK03918 642 LEELRKELEELEK--KYSEEEYEELREEYLELSRELAGLRAELEELEKRreeIKKTLEKLKE-ELEEREKAKKELEKLEK 718
|
|
| PHA02736 |
PHA02736 |
Viral ankyrin protein; Provisional |
64-191 |
2.65e-04 |
|
Viral ankyrin protein; Provisional
Pssm-ID: 165103 [Multi-domain] Cd Length: 154 Bit Score: 42.56 E-value: 2.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 64 RDRKDRTVLHLACAHGrvQVVTLLLHRRCQID----ICDRLNR--TPLMKAVHSQEEACAI----VLLECGANPNIED-I 132
Cdd:PHA02736 13 PDIEGENILHYLCRNG--GVTDLLAFKNAISDenryLVLEYNRhgKQCVHIVSNPDKADPQeklkLLMEWGADINGKErV 90
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 133 YGNTALHYAVYNKGTSLAERLLSH-HANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQA 191
Cdd:PHA02736 91 FGNTPLHIAVYTQNYELATWLCNQpGVNMEILNYAFKTPYYVACERHDAKMMNILRAKGA 150
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
86-141 |
4.10e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 39.25 E-value: 4.10e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 767954779 86 LLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYA 141
Cdd:pfam13857 1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| Cast |
pfam10174 |
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ... |
282-523 |
5.98e-04 |
|
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.
Pssm-ID: 431111 [Multi-domain] Cd Length: 766 Bit Score: 43.66 E-value: 5.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 282 RKERAKAEHNLKVASEEKQERLQRSENKQPQDSQ--SYGKKKDamygNFMLKKDIAMLKEELYAIKndsLRKEKKYIQEI 359
Cdd:pfam10174 474 KKENKDLKEKVSALQPELTEKESSLIDLKEHASSlaSSGLKKD----SKLKSLEIAVEQKKEECSK---LENQLKKAHNA 546
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 360 KSITEINANFEKSVRLNEKmitkTVARYSQQLNDLKAENARLNS---ELEKEKHNKERLEAEVESLHS------SLATAI 430
Cdd:pfam10174 547 EEAVRTNPEINDRIRLLEQ----EVARYKEESGKAQAEVERLLGilrEVENEKNDKDKKIAELESLTLrqmkeqNKKVAN 622
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 431 NEYNEIVERKDLELVLWRAddvsRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQLD 510
Cdd:pfam10174 623 IKHGQQEMKKKGAQLLEEA----RRREDNLADNSQQLQLEELMGALEKTRQELDATKARLSSTQQSLAEKDGHLTNLRAE 698
|
250
....*....|...
gi 767954779 511 LRQAQHRIKEMKQ 523
Cdd:pfam10174 699 RRKQLEEILEMKQ 711
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
272-918 |
7.13e-04 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 43.59 E-value: 7.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 272 AAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQpqdsqsygKKKDAMYGNFMLKKDIAMLKEElyaikndslrk 351
Cdd:PTZ00121 1180 AARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEAR--------KAEDAKKAEAVKKAEEAKKDAE----------- 1240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 352 EKKYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQQLNDL-KAENARLNSELEKEKHNKERLEAEVESLHSSLATAI 430
Cdd:PTZ00121 1241 EAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELkKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEA 1320
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 431 NEYNEIVERKDLELV-----LWRADDVSR--HEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDA--LREKT 501
Cdd:PTZ00121 1321 KKKAEEAKKKADAAKkkaeeAKKAAEAAKaeAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKAdeAKKKA 1400
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 502 LALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNKEIVINIHRDCL 581
Cdd:PTZ00121 1401 EEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAE 1480
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 582 ENGKEDLLEERNKELMKEYNYLKEKllqcEKEKAEREVIVREFQEELVDHLKTFSISESPLEGTSHCHINLNETWTSKKK 661
Cdd:PTZ00121 1481 EAKKADEAKKKAEEAKKKADEAKKA----AEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEE 1556
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 662 LFQVEiqPEEKHEEFRKLFELISLLNYTADQIRK-KNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMD 740
Cdd:PTZ00121 1557 LKKAE--EKKKAEEAKKAEEDKNMALRKAEEAKKaEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKK 1634
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 741 ILFKKLKQ-----KFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVE 815
Cdd:PTZ00121 1635 VEQLKKKEaeekkKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEE 1714
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 816 LGKLQEYKSELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKDNTASLKKKElTLKDVECKFSKMKTAYEEVTTELEEFK 895
Cdd:PTZ00121 1715 KKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEE-EKKAEEIRKEKEAVIEEELDEEDEKRR 1793
|
650 660
....*....|....*....|...
gi 767954779 896 EAFAGAVKANNSMSKKLMKSDKK 918
Cdd:PTZ00121 1794 MEVDKKIKDIFDNFANIIEGGKE 1816
|
|
| SMC_N |
pfam02463 |
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ... |
215-914 |
8.93e-04 |
|
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.
Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 43.42 E-value: 8.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 215 IVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQ-QILEHKNKMLKNHLRNDNQETAAMKPANLKKRKERAKaehnlk 293
Cdd:pfam02463 189 IIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEyLLYLDYLKLNEERIDLLQELLRDEQEEIESSKQEIEK------ 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 294 vaSEEKQERLQRSENKQPQdSQSYGKKKDAMYGNFMLKKDIAMLKEELyaiKNDSLRKEKKYIQEIKSITEINANFEKSV 373
Cdd:pfam02463 263 --EEEKLAQVLKENKEEEK-EKKLQEEELKLLAKEEEELKSELLKLER---RKVDDEEKLKESEKEKKKAEKELKKEKEE 336
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 374 RLNEKMITKTVARYSQQlndLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINEYNEIVERKDLELvlwrADDVS 453
Cdd:pfam02463 337 IEELEKELKELEIKREA---EEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEE----KEAQL 409
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 454 RHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKemkqmhpngEAKES 533
Cdd:pfam02463 410 LLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLK---------ETQLV 480
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 534 QSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNKEIVINIHRDClENGKEDLLEERNKELMKEYNYLKEKLLQCEKE 613
Cdd:pfam02463 481 KLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISA-HGRLGDLGVAVENYKVAISTAVIVEVSATADE 559
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 614 KAEREVIVREFQEELVDHLKTFSISESPLEGTSHCHINLNETWTSKKKLFQVEIQPE---------EKHEEFRKLFELIS 684
Cdd:pfam02463 560 VEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADeddkrakvvEGILKDTELTKLKE 639
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 685 LLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFNDLVAEKEAVSSEC 764
Cdd:pfam02463 640 SAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEA 719
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 765 VNLakdNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLKThMEKDMVELGKLQEYKSELDERAVQEIEKLEEIHLQK 844
Cdd:pfam02463 720 EEL---LADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKK-EEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEK 795
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 845 QAEYEKQLEQLNKDNTASLKKKELTLKDVECKFSKMKTAYEEVTTELEEFKEAFAGAVKANNSMSKKLMK 914
Cdd:pfam02463 796 LKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITK 865
|
|
| COG5022 |
COG5022 |
Myosin heavy chain [General function prediction only]; |
279-890 |
9.37e-04 |
|
Myosin heavy chain [General function prediction only];
Pssm-ID: 227355 [Multi-domain] Cd Length: 1463 Bit Score: 43.14 E-value: 9.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 279 LKKRKE-RAKAEHNLKVASEEKQERLQRSENKQPQD----------SQSYGKKKDAmygnFMLKKDIAMLK--------- 338
Cdd:COG5022 806 LGSRKEyRSYLACIIKLQKTIKREKKLRETEEVEFSlkaevliqkfGRSLKAKKRF----SLLKKETIYLQsaqrvelae 881
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 339 ----EELYAIKNDSLRKEKKYiQEIKSITEINANFEKSVRLNEKMITKTVARYSQQLNdlkaeNARLNSELEKEKHNKER 414
Cdd:COG5022 882 rqlqELKIDVKSISSLKLVNL-ELESEIIELKKSLSSDLIENLEFKTELIARLKKLLN-----NIDLEEGPSIEYVKLPE 955
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 415 LEaEVESLHSSLATAINEYNEIVerkdlelvlwraddvsrhEKMGSNISQLTDKNELLtEQVHKARVKFNTLKGKLRETR 494
Cdd:COG5022 956 LN-KLHEVESKLKETSEEYEDLL------------------KKSTILVREGNKANSEL-KNFKKELAELSKQYGALQEST 1015
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 495 DALREKTLALGSVQLDLRQAQHRIKEMKQMhpngeaKESQSIGKQNSLEERIRQQELENLLLERQLEDARkegDNKEIVI 574
Cdd:COG5022 1016 KQLKELPVEVAELQSASKIISSESTELSIL------KPLQKLKGLLLLENNQLQARYKALKLRRENSLLD---DKQLYQL 1086
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 575 NIHRDCLENGKEDLLEERNKELMKEYNYL--------KEKLLQCEKEKAEREVIVREFQEELVDHLKTFSISESPLEGTS 646
Cdd:COG5022 1087 ESTENLLKTINVKDLEVTNRNLVKPANVLqfivaqmiKLNLLQEISKFLSQLVNTLEPVFQKLSVLQLELDGLFWEANLE 1166
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 647 HCHINLNETWTSKKKLFQVEIQPEEKH------EEFRKLFELISLLNYTADQIRKKNRELEEEA---TGYKKCLEMTINM 717
Cdd:COG5022 1167 ALPSPPPFAALSEKRLYQSALYDEKSKlsssevNDLKNELIALFSKIFSGWPRGDKLKKLISEGwvpTEYSTSLKGFNNL 1246
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 718 LNAFAnedfschgdlNTDQLKMDILFKKLKQKFNDLVA---EKEAVSSECVNLAKDNEVLHQELLSMR--------NVQE 786
Cdd:COG5022 1247 NKKFD----------TPASMSNEKLLSLLNSIDNLLSSyklEEEVLPATINSLLQYINVGLFNALRTKasslrwksATEV 1316
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 787 KCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDERAVQ----------EIEKLeeIHLQKQAEYEKQLE-QL 855
Cdd:COG5022 1317 NYNSEELDDWCREFEISDVDEELEELIQAVKVLQLLKDDLNKLDELldacyslnpaEIQNL--KSRYDPADKENNLPkEI 1394
|
650 660 670
....*....|....*....|....*....|....*
gi 767954779 856 NKDNTASLKKKELTLKDveCKFSKMKTAYEEVTTE 890
Cdd:COG5022 1395 LKKIEALLIKQELQLSL--EGKDETEVHLSEIFSE 1427
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
590-932 |
1.04e-03 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 43.13 E-value: 1.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 590 EERNKELMKEYNYLKEKLlQCEKEKAEReviVREFQEELVDhlktfsisespLEGTSHCHiNLNETWTSKKklfQVEIQP 669
Cdd:TIGR02169 186 IERLDLIIDEKRQQLERL-RREREKAER---YQALLKEKRE-----------YEGYELLK-EKEALERQKE---AIERQL 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 670 EEKHEEFRKLFELISLLNytaDQIRKKNRELEEEAtgyKKCLEMTINMLNAFANEDFSCHGDLntDQLKMDILFKKLKQK 749
Cdd:TIGR02169 247 ASLEEELEKLTEEISELE---KRLEEIEQLLEELN---KKIKDLGEEEQLRVKEKIGELEAEI--ASLERSIAEKERELE 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 750 fnDLVAEkeavssecvnLAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELG----KLQEYKSE 825
Cdd:TIGR02169 319 --DAEER----------LAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEevdkEFAETRDE 386
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 826 LDERaVQEIEKLEEIHLQKQAEYEKQLEQLNKdNTASLKKKELTLKDVECKFSKMKTAYEEVTTELEEFKEAFAGAVKAN 905
Cdd:TIGR02169 387 LKDY-REKLEKLKREINELKRELDRLQEELQR-LSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADL 464
|
330 340
....*....|....*....|....*..
gi 767954779 906 NSMSKKLMKSDKKIAVISTKLfTEKQR 932
Cdd:TIGR02169 465 SKYEQELYDLKEEYDRVEKEL-SKLQR 490
|
|
| CCDC158 |
pfam15921 |
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ... |
244-445 |
1.22e-03 |
|
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.
Pssm-ID: 464943 [Multi-domain] Cd Length: 1112 Bit Score: 42.80 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 244 DLRSIRQQILeHKNKMLKNHLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKKKDA 323
Cdd:pfam15921 650 DIKQERDQLL-NEVKTSRNELNSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKV 728
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 324 MYGnfmLKKDIAMLKEELyaiknDSLRKEKKYIQEIKSiteiNANFEKSVRLNEKmitktvARYSQQLNDLKAENARLNS 403
Cdd:pfam15921 729 AMG---MQKQITAKRGQI-----DALQSKIQFLEEAMT----NANKEKHFLKEEK------NKLSQELSTVATEKNKMAG 790
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 767954779 404 ELEKEKHNKERLEAEVESLHSSLATAINEYNE---IVERKDLELV 445
Cdd:pfam15921 791 ELEVLRSQERRLKEKVANMEVALDKASLQFAEcqdIIQRQEQESV 835
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
330-627 |
1.25e-03 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 42.75 E-value: 1.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 330 LKKDIAMLKEELYAIKN--DSLRKEKKYI-QEIKSITEINANFEKSVRLNEK---MITKTVARYSQQLNDLKAENARLNS 403
Cdd:TIGR02169 672 EPAELQRLRERLEGLKRelSSLQSELRRIeNRLDELSQELSDASRKIGEIEKeieQLEQEEEKLKERLEELEEDLSSLEQ 751
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 404 ELEKEKHNKERLEAEVESLHSSLATAINEYNEIvERKDLElvlwraddvsrhekmgSNISQLTDKNELLTEQVHKarvkf 483
Cdd:TIGR02169 752 EIENVKSELKELEARIEELEEDLHKLEEALNDL-EARLSH----------------SRIPEIQAELSKLEEEVSR----- 809
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 484 ntLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDA 563
Cdd:TIGR02169 810 --IEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDL 887
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767954779 564 RKEGDNKEivinIHRDCLENGKEDLLEERNKeLMKEYNYLKEKLLQCEKEKAEREVIVREFQEE 627
Cdd:TIGR02169 888 KKERDELE----AQLRELERKIEELEAQIEK-KRKRLSELKAKLEALEEELSEIEDPKGEDEEI 946
|
|
| PRK11281 |
PRK11281 |
mechanosensitive channel MscK; |
775-901 |
1.48e-03 |
|
mechanosensitive channel MscK;
Pssm-ID: 236892 [Multi-domain] Cd Length: 1113 Bit Score: 42.59 E-value: 1.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 775 HQELLSMRNVQEKCEKLeKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDErAVQEIEKLEeihlQKQAEYEKQLEQ 854
Cdd:PRK11281 32 NGDLPTEADVQAQLDAL-NKQKLLEAEDKLVQQDLEQTLALLDKIDRQKEETEQ-LKQQLAQAP----AKLRQAQAELEA 105
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 767954779 855 LNKDNTASLKK--KELTLKDVECKFskmktayEEVTTELEEFKEAFAGA 901
Cdd:PRK11281 106 LKDDNDEETREtlSTLSLRQLESRL-------AQTLDQLQNAQNDLAEY 147
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
166-198 |
2.33e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 36.50 E-value: 2.33e-03
10 20 30
....*....|....*....|....*....|....
gi 767954779 166 EGNTPLLFAINSRRQH-MVEFLLKNQANIHAVDN 198
Cdd:pfam00023 1 DGNTPLHLAAGRRGNLeIVKLLLSKGADVNARDK 34
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
330-599 |
3.35e-03 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 41.46 E-value: 3.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 330 LKKDIAMLKEELYAIKNDSLRKEKKYIQ-EIKSITEINANFEKSVRLNEKMITK---TVARYSQQLNDLKAENARLNSEL 405
Cdd:COG1196 218 LKEELKELEAELLLLKLRELEAELEELEaELEELEAELEELEAELAELEAELEElrlELEELELELEEAQAEEYELLAEL 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 406 EKEKH--------------NKERLEAEVESLHSSLATAINEYNEIVERKDLELVLWRADDVSRHEkmgsnisQLTDKNEL 471
Cdd:COG1196 298 ARLEQdiarleerrreleeRLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAE-------AEEALLEA 370
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 472 LTEQVHKARVKFNTLKGKLRETRDALREKTlALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQEL 551
Cdd:COG1196 371 EAELAEAEEELEELAEELLEALRAAAELAA-QLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAE 449
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 767954779 552 ENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKE 599
Cdd:COG1196 450 EEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLL 497
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
265-920 |
4.31e-03 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 41.28 E-value: 4.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 265 RNDNQETAAMKPAnlKKRKERAKAEHNLKVASEEK-QERLQRSEN----KQPQDSQSYGKKKDAMYGNFMLKKDIAMLKE 339
Cdd:PTZ00121 1084 KEDNRADEATEEA--FGKAEEAKKTETGKAEEARKaEEAKKKAEDarkaEEARKAEDARKAEEARKAEDAKRVEIARKAE 1161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 340 ELYAIKNDSLRKEKKYIQEIKSITEINANFEksVRLNEKMITKTVARYSQqlNDLKAENARLNSELEKEKHNKERLEAEV 419
Cdd:PTZ00121 1162 DARKAEEARKAEDAKKAEAARKAEEVRKAEE--LRKAEDARKAEAARKAE--EERKAEEARKAEDAKKAEAVKKAEEAKK 1237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 420 ESLHSSLATAINEYNEIVERKDLELVLWRADDVSRHEKMGSNISQLTDKNELL-TEQVHKA--RVKFNTLKGKLRETRDA 496
Cdd:PTZ00121 1238 DAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKkADEAKKAeeKKKADEAKKKAEEAKKA 1317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 497 LREKTLAlGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNKEIVINI 576
Cdd:PTZ00121 1318 DEAKKKA-EEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEA 1396
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 577 HRDCLENGKEDLLEERNKELMKEYNYLKEKLLqcEKEKAErEVIVREFQEELVDHLKTFSISESPLEgtshchiNLNETW 656
Cdd:PTZ00121 1397 KKKAEEDKKKADELKKAAAAKKKADEAKKKAE--EKKKAD-EAKKKAEEAKKADEAKKKAEEAKKAE-------EAKKKA 1466
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 657 TSKKKLFQVEIQPEE--KHEEFRKlfelisllnyTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNT 734
Cdd:PTZ00121 1467 EEAKKADEAKKKAEEakKADEAKK----------KAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKA 1536
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 735 DQLKMDILFKK---LKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKceKLEKDKKMLEEEVLNLKTHMEK 811
Cdd:PTZ00121 1537 DEAKKAEEKKKadeLKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEA--RIEEVMKLYEEEKKMKAEEAKK 1614
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 812 DMVELGKLQEYKSELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKDNTASLKKKEltlkdveckfSKMKTAYEEVTTEL 891
Cdd:PTZ00121 1615 AEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKA----------EEDKKKAEEAKKAE 1684
|
650 660
....*....|....*....|....*....
gi 767954779 892 EEFKEAfAGAVKANNSMSKKLMKSDKKIA 920
Cdd:PTZ00121 1685 EDEKKA-AEALKKEAEEAKKAEELKKKEA 1712
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
93-235 |
4.70e-03 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 40.83 E-value: 4.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 93 QIDICDRLNRTPLMKAVHSQEEACAIVLLEcgaNPNIEDIYGNTALHYAVYN-----------KGTSLAERLLSHHANIE 161
Cdd:TIGR00870 44 NINCPDRLGRSALFVAAIENENLELTELLL---NLSCRGAVGDTLLHAISLEyvdaveaillhLLAAFRKSGPLELANDQ 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 162 ALNKE--GNTPLLFAINSRRQHMVEFLLKNQANIHA------------VDNFK--RTALILAVQHNLSSIVTLLLQQNIR 225
Cdd:TIGR00870 121 YTSEFtpGITALHLAAHRQNYEIVKLLLERGASVPAracgdffvksqgVDSFYhgESPLNAAACLGSPSIVALLSEDPAD 200
|
170
....*....|
gi 767954779 226 ISSQDMFGQT 235
Cdd:TIGR00870 201 ILTADSLGNT 210
|
|
| TRPV1-4 |
cd22193 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ... |
166-235 |
6.13e-03 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Pssm-ID: 411977 [Multi-domain] Cd Length: 607 Bit Score: 40.55 E-value: 6.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 166 EGNTPLLFAINSRRQHMVEFLLKNQANIHAVDN--------------FKRTALILAVQHNLSSIVTLLLQ---QNIRISS 228
Cdd:cd22193 75 EGQTALHIAIERRQGDIVALLVENGADVHAHAKgrffqpkyqgegfyFGELPLSLAACTNQPDIVQYLLEnehQPADIEA 154
|
....*..
gi 767954779 229 QDMFGQT 235
Cdd:cd22193 155 QDSRGNT 161
|
|
| TRPV1 |
cd22196 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 ... |
167-235 |
6.48e-03 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 (TRPV1), a capsaicin (vanilloid) receptor, is the founding member of the vanilloid TRP subfamily (TRPV). In humans, it is expressed in the brain, kidney, pancreas, testis, uterus, spleen, stomach, small intestine, lung and liver. TRPV1 has been implicated to have function in thermo-sensation (heat), autonomic thermoregulation, nociception, food intake regulation, and multiple functions in the gastrointestinal (GI) tract. The receptor has also been involved in growth cone guidance, long-term depression, endocannabinoid signaling and osmosensing in the central nervous system. TRPV1 is up regulated in several human pathological conditions including vulvodynia, GI inflammation, Crohn's disease and ulcerative colitis. TRPV1 knock-out mice exhibit impaired sensation to thermal-mechanical acute pain. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Pssm-ID: 411980 [Multi-domain] Cd Length: 649 Bit Score: 40.17 E-value: 6.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 167 GNTPLLFAINSRRQHMVEFLLKNQANIHAVDN---FKRTA-----------LILAVQHNLSSIVTLLLQ---QNIRISSQ 229
Cdd:cd22196 94 GQTALHIAIERRNMHLVELLVQNGADVHARASgefFKKKKggpgfyfgelpLSLAACTNQLDIVKFLLEnphSPADISAR 173
|
....*.
gi 767954779 230 DMFGQT 235
Cdd:cd22196 174 DSMGNT 179
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
380-550 |
6.69e-03 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 39.81 E-value: 6.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 380 ITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINEYNE-----------------IVERKDL 442
Cdd:COG3883 35 AQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGEraralyrsggsvsyldvLLGSESF 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 443 ELVLWRADdvsrhekmgsNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQldlRQAQHRIKEMK 522
Cdd:COG3883 115 SDFLDRLS----------ALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAK---AELEAQQAEQE 181
|
170 180
....*....|....*....|....*...
gi 767954779 523 QMHPNGEAKESQSIGKQNSLEERIRQQE 550
Cdd:COG3883 182 ALLAQLSAEEAAAEAQLAELEAELAAAE 209
|
|
| TRPV1 |
cd22196 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 ... |
134-204 |
7.62e-03 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 (TRPV1), a capsaicin (vanilloid) receptor, is the founding member of the vanilloid TRP subfamily (TRPV). In humans, it is expressed in the brain, kidney, pancreas, testis, uterus, spleen, stomach, small intestine, lung and liver. TRPV1 has been implicated to have function in thermo-sensation (heat), autonomic thermoregulation, nociception, food intake regulation, and multiple functions in the gastrointestinal (GI) tract. The receptor has also been involved in growth cone guidance, long-term depression, endocannabinoid signaling and osmosensing in the central nervous system. TRPV1 is up regulated in several human pathological conditions including vulvodynia, GI inflammation, Crohn's disease and ulcerative colitis. TRPV1 knock-out mice exhibit impaired sensation to thermal-mechanical acute pain. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Pssm-ID: 411980 [Multi-domain] Cd Length: 649 Bit Score: 40.17 E-value: 7.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 134 GNTALHYAVYNKGTSLAERLLSHHANIEA--------LNKEGN------TPLLFAINSRRQHMVEFLLKNQ---ANIHAV 196
Cdd:cd22196 94 GQTALHIAIERRNMHLVELLVQNGADVHArasgeffkKKKGGPgfyfgeLPLSLAACTNQLDIVKFLLENPhspADISAR 173
|
....*...
gi 767954779 197 DNFKRTAL 204
Cdd:cd22196 174 DSMGNTVL 181
|
|
| DR0291 |
COG1579 |
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ... |
460-631 |
7.92e-03 |
|
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];
Pssm-ID: 441187 [Multi-domain] Cd Length: 236 Bit Score: 39.14 E-value: 7.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 460 SNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGE-AKESQSIGK 538
Cdd:COG1579 17 SELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRnNKEYEALQK 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 539 Q-NSLEERIRQQELENLLLERQLEDARKEGDNKEIVINihrdclenGKEDLLEERNKELMKEYNYLKEKLlqcEKEKAER 617
Cdd:COG1579 97 EiESLKRRISDLEDEILELMERIEELEEELAELEAELA--------ELEAELEEKKAELDEELAELEAEL---EELEAER 165
|
170
....*....|....
gi 767954779 618 EVIVREFQEELVDH 631
Cdd:COG1579 166 EELAAKIPPELLAL 179
|
|
| YkyA |
pfam10368 |
Putative cell-wall binding lipoprotein; YkyA is a family of proteins containing a lipoprotein ... |
783-897 |
7.99e-03 |
|
Putative cell-wall binding lipoprotein; YkyA is a family of proteins containing a lipoprotein signal and a hydrolase domain. It is similar to cell wall binding proteins and might also be recognisable by a host immune defence system. It is thus likely to belong to pathways important for pathogenicity.
Pssm-ID: 431235 [Multi-domain] Cd Length: 185 Bit Score: 38.73 E-value: 7.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 783 NVQEKCEKLEKDKKMLE---EEVLNLKTHMEKdmVELGKLQEYKSELderaVQEIEKLEEIHLQKQAEYEKQLEqLNKDN 859
Cdd:pfam10368 62 NVEEREELLEKEKESIEeakEEFKKIKEIIEE--IEDEELKKEAEEL----IDAMEERYEAYDELYDAYKKALE-LDKEL 134
|
90 100 110
....*....|....*....|....*....|....*...
gi 767954779 860 TASLKKKELTLKDVECKFSKMKTAYEEVTTELEEFKEA 897
Cdd:pfam10368 135 YEMLKDEDLTLEELQEQIEKINESYEEVKEANEQFNEY 172
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
281-441 |
8.70e-03 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 40.05 E-value: 8.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 281 KRKERAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKkkdamygnfmLKKDIAMLKEELyaikndslRKEKKYIQEIK 360
Cdd:TIGR02169 848 QIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGD----------LKKERDELEAQL--------RELERKIEELE 909
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 361 SiteinANFEKSVRLNEKMITKTVArySQQLNDLKAENARLNSE------LEKEKHNKERLEAEVESLHSSLATAINEYN 434
Cdd:TIGR02169 910 A-----QIEKKRKRLSELKAKLEAL--EEELSEIEDPKGEDEEIpeeelsLEDVQAELQRVEEEIRALEPVNMLAIQEYE 982
|
....*..
gi 767954779 435 EIVERKD 441
Cdd:TIGR02169 983 EVLKRLD 989
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
468-902 |
9.01e-03 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 39.75 E-value: 9.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 468 KNELLTEQVHKARVKFNTLKGK---LRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEE 544
Cdd:COG4717 65 KPELNLKELKELEEELKEAEEKeeeYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQELEALEAELAEL 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 545 RIRQQELENLL-----LERQLEDARKEGDNKEIVINIHRDCLENGKEDLLE---ERNKELMKEYNYLKEKLLQCEKEKAE 616
Cdd:COG4717 145 PERLEELEERLeelreLEEELEELEAELAELQEELEELLEQLSLATEEELQdlaEELEELQQRLAELEEELEEAQEELEE 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 617 REVIVREFQEELVDH--------LKTFSISESPLEGTSHCHINLNETWTSKKKLFQVEIQPEEKHEEFRKLFELISLLNY 688
Cdd:COG4717 225 LEEELEQLENELEAAaleerlkeARLLLLIAAALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEA 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 689 TADQIRKKNRELEEEA-TGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKfnDLVAEKEAVssecvnL 767
Cdd:COG4717 305 EELQALPALEELEEEElEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLE--ELEQEIAAL------L 376
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954779 768 AKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMvELGKLQEYKSELD--ERAVQEIEKLEEIHLQKQ 845
Cdd:COG4717 377 AEAGVEDEEELRAALEQAEEYQELKEELEELEEQLEELLGELEELL-EALDEEELEEELEelEEELEELEEELEELREEL 455
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767954779 846 AEYEKQLEQLNKDNTASLKKKEL-----TLKDVECKFSKMKTAYEEVTTELEEFKEAFAGAV 902
Cdd:COG4717 456 AELEAELEQLEEDGELAELLQELeelkaELRELAEEWAALKLALELLEEAREEYREERLPPV 517
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
69-99 |
1.00e-02 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 34.57 E-value: 1.00e-02
10 20 30
....*....|....*....|....*....|..
gi 767954779 69 RTVLHLACAH-GRVQVVTLLLHRRCQIDICDR 99
Cdd:pfam00023 3 NTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
|
|
| |
